BRPI0509148B8 - composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina contendo tensoativos, seus usos e respectivos processos de fabricação - Google Patents
composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina contendo tensoativos, seus usos e respectivos processos de fabricaçãoInfo
- Publication number
- BRPI0509148B8 BRPI0509148B8 BRPI0509148A BRPI0509148A BRPI0509148B8 BR PI0509148 B8 BRPI0509148 B8 BR PI0509148B8 BR PI0509148 A BRPI0509148 A BR PI0509148A BR PI0509148 A BRPI0509148 A BR PI0509148A BR PI0509148 B8 BRPI0509148 B8 BR PI0509148B8
- Authority
- BR
- Brazil
- Prior art keywords
- lipase
- pharmaceutical compositions
- oral pharmaceutical
- manufacturing processes
- pancreatin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/745—Polymers of hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina contendo tensoativos, seus usos e respectivos processos de fabricação. a presente invenção refere-se a novas composições farmacêuticas de produtos contendo lipase para administração por via oral, em particular, pancreatina e produtos contendo pancreatina, ou de produtos enzimáticos que contêm pelo menos uma lipase de origem não-animal, especialmente de origem microbiana. estas composições farmacêuticas melhoram a atividade lipolítica e, em particular, resultam na estabilização da lipase na faixa de ph ácido. estas novas composições farmacêuticas orais são caracterizadas por conterem um sistema que compreende, pelo menos, um tensoativo e um co-tensoativo e, optionalmente, uma fase lipofilica, e por serem autoemulsionáveis em contato com uma fase hidrofílica e uma fase lipofílica. estas novas composições farmacêuticas são bem apropriadas para o tratamento e/ou profilaxia de má digestão, em particular, má digestão baseada em insuficiência pancreática exócrina crônica, em mamíferos e seres humanos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55499304P | 2004-03-22 | 2004-03-22 | |
EP04101164.4A EP1579869A1 (de) | 2004-03-22 | Pharmazeutische Zusammensetzung enthaltend Lipase, insbesondere Pankreatin, und Tenside | |
PCT/EP2005/051295 WO2005092370A1 (en) | 2004-03-22 | 2005-03-21 | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0509148A BRPI0509148A (pt) | 2007-09-11 |
BRPI0509148B1 BRPI0509148B1 (pt) | 2016-07-12 |
BRPI0509148B8 true BRPI0509148B8 (pt) | 2021-05-25 |
Family
ID=34964300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0509148A BRPI0509148B8 (pt) | 2004-03-22 | 2005-03-21 | composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina contendo tensoativos, seus usos e respectivos processos de fabricação |
Country Status (15)
Country | Link |
---|---|
US (3) | US8802087B2 (pt) |
EP (1) | EP1729797B1 (pt) |
JP (1) | JP5032300B2 (pt) |
CN (1) | CN1933850B (pt) |
AT (1) | ATE407693T1 (pt) |
AU (1) | AU2005227090B2 (pt) |
BR (1) | BRPI0509148B8 (pt) |
CA (1) | CA2560613C (pt) |
DE (1) | DE602005009677D1 (pt) |
ES (1) | ES2314646T3 (pt) |
HK (1) | HK1101342A1 (pt) |
PL (1) | PL1729797T3 (pt) |
PT (1) | PT1729797E (pt) |
RU (1) | RU2381813C2 (pt) |
WO (1) | WO2005092370A1 (pt) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
RU2413532C2 (ru) * | 2005-07-29 | 2011-03-10 | Зольвай Фармасьютиклз Гмбх | Способ получения стерилизованного порошкообразного панкреатина |
US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
DE102006001554A1 (de) * | 2006-01-05 | 2007-07-12 | Ipc Process-Center Gmbh & Co. | Micropellets für die Herstellung von Tiernahrungspellets |
US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
CN105112386A (zh) | 2006-12-21 | 2015-12-02 | 诺维信公司 | 用于药物用途的脂肪酶变体 |
EP2079445B1 (en) | 2007-02-20 | 2015-11-04 | Aptalis Pharma Limited | Stable digestive enzyme compositions |
US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
US10087493B2 (en) | 2008-03-07 | 2018-10-02 | Aptalis Pharma Canada Ulc | Method for detecting infectious parvovirus in pharmaceutical preparations |
US8658163B2 (en) | 2008-03-13 | 2014-02-25 | Curemark Llc | Compositions and use thereof for treating symptoms of preeclampsia |
US8084025B2 (en) | 2008-04-18 | 2011-12-27 | Curemark Llc | Method for the treatment of the symptoms of drug and alcohol addiction |
EP2318035B1 (en) | 2008-07-01 | 2019-06-12 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
US10776453B2 (en) | 2008-08-04 | 2020-09-15 | Galenagen, Llc | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain |
EP2165717A1 (de) | 2008-08-27 | 2010-03-24 | Nordmark Arzneimittel GmbH & Co.KG | Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte |
KR20170005191A (ko) | 2009-01-06 | 2017-01-11 | 큐어론 엘엘씨 | 이. 콜라이에 의한 구강 감염의 치료 또는 예방을 위한 조성물 및 방법 |
ES2882518T3 (es) | 2009-01-06 | 2021-12-02 | Galenagen Llc | Composición que comprende proteasa, amilasa y lipasa |
EP2391382B1 (de) * | 2009-01-29 | 2014-06-04 | Nordmark Arzneimittel GmbH & Co.KG | Pharmazeutisches präparat enthaltend lipase bakteriellen ursprungs |
US9056050B2 (en) | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
US20110097401A1 (en) | 2009-06-12 | 2011-04-28 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
EP2295039B2 (de) * | 2009-08-28 | 2022-10-26 | Nordmark Pharma GmbH | Verfahren zur Herstellung von Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und hiernach hergestellte Pankreatin-Pellets |
US8784884B2 (en) | 2009-09-17 | 2014-07-22 | Stephen Perrett | Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency |
PL2621476T5 (pl) | 2010-10-01 | 2022-06-06 | Société des Produits Nestlé S.A. | Dojelitowe powlekane preparaty pankrelipazy o niskiej mocy |
EP2489349B1 (de) | 2011-02-17 | 2014-05-28 | Nordmark Arzneimittel GmbH & Co.KG | Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und Verfahren zu deren Herstellung |
ES2804223T3 (es) | 2011-04-21 | 2021-02-04 | Curemark Llc | Compuestos para el tratamiento de Trastornos Neuropsiquiátricos |
HUE026560T2 (hu) | 2011-08-08 | 2016-06-28 | Allergan Pharmaceuticals Int Ltd | Eljárás emésztõ enzimeket tartalmazó szilárd készítmények feloldódási viselkedésének vizsgálatára |
US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
NZ716627A (en) * | 2012-01-03 | 2017-08-25 | Curemark Llc | Methods of treating behavioral symptoms of neurological and mental disorders |
US9668474B2 (en) | 2012-02-10 | 2017-06-06 | Stepan Company | Structured surfactant suspending systems |
US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
CA2897878A1 (en) * | 2013-01-14 | 2014-07-17 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
CN106163544A (zh) | 2013-08-09 | 2016-11-23 | 阿勒根制药国际有限公司 | 适于经肠施用的消化酶组合物 |
JP2014193909A (ja) * | 2014-06-04 | 2014-10-09 | Nordmark Arzneimittel Gmbh & Co Kg | 医薬調製物 |
EP3157568A1 (en) | 2014-06-19 | 2017-04-26 | Aptalis Pharma Limited | Methods for removing viral contaminants from pancreatic extracts |
MX2017005941A (es) * | 2014-11-05 | 2018-02-13 | Abbott Laboratories Gmbh | Procesos para la producción de composiciones con perfil de seguridad mejorado teniendo actividad lipasa y composiciones adecuadas para medicamentos. |
US10739353B2 (en) * | 2014-12-31 | 2020-08-11 | Signpath Pharma, Inc. | Suppression of cytokine release and cytokine storm |
WO2016126970A1 (en) | 2015-02-04 | 2016-08-11 | Abbvie Inc. | Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency |
CN104730014B (zh) * | 2015-03-27 | 2017-08-04 | 宁波博泰生物技术有限公司 | 一种血清脂肪酶测定试剂盒及其制备方法 |
DE102015114862A1 (de) * | 2015-09-04 | 2017-03-09 | Nordmark Arzneimittel Gmbh & Co. Kg | Pharmazeutische Zusammensetzung, enthaltend eine bakterielle Lipase |
US10463699B2 (en) | 2016-04-04 | 2019-11-05 | Omeza LLC | Fish oil topical composition |
US10836890B2 (en) * | 2017-01-25 | 2020-11-17 | Nano And Advanced Materials Institute Limited | Mechanically reinforced, transparent, anti-biofouling thermoplastic resin composition and manufacturing method thereof |
DE102017104472A1 (de) | 2017-03-03 | 2018-09-06 | Nordmark Arzneimittel Gmbh & Co. Kg | Schmelztablette enthaltend Burlulipase und daraus hergestellte pharmazeutische Zusammensetzung |
CN110075279A (zh) * | 2019-04-25 | 2019-08-02 | 淮安麦德森制药有限公司 | 胰酶微球及其生产方法 |
RU2706003C1 (ru) * | 2019-09-09 | 2019-11-13 | Акционерное общество "АВВА РУС" | Микрогранулы, содержащие панкреатин |
US20210236629A1 (en) * | 2020-02-05 | 2021-08-05 | Jubilant Pharma Holdings Inc. | Self-emulsifying dosage forms of allergen and their preparation thereof |
US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
EP4082518A1 (en) * | 2021-04-28 | 2022-11-02 | Cnce Innovacion, S.L. | Fatty acid compositions for the treatment and prevention of hair loss and alopecia |
CA3241218A1 (en) * | 2021-12-16 | 2023-06-22 | Dinesh SRINIVASAN | Stable lipase formulations and methods thereof |
Family Cites Families (149)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3324002A (en) * | 1962-09-17 | 1967-06-06 | Armour Pharma | Anti-inflammatory preparations containing proteolytic enzymes and adrenal glucocorticoids |
US3803305A (en) * | 1962-12-28 | 1974-04-09 | Rolland A Lab | Process for obtaining extracts from pancreas |
US3956483A (en) * | 1968-10-24 | 1976-05-11 | Wilson Pharmaceutical & Chemical Corporation | Preparing pancreatin |
DE2035739A1 (en) | 1970-07-18 | 1972-01-27 | Röhm FmbH, 6100 Darmstadt | Oral enzyme prepsn - consisting of granulate with gastric juices-resistant coating in tablet or capsule form |
US3991180A (en) * | 1972-03-06 | 1976-11-09 | Rohm And Haas Company | Stabilization of internally administered pancreatic lipase |
FR2183546B1 (pt) * | 1972-05-10 | 1975-06-20 | Servier Lab | |
DE2410241A1 (de) | 1974-03-04 | 1975-09-18 | Christian Brunnengraeber Chem | Granulataehnliche darreichungsform fuer arzneimittel |
DE2512746C3 (de) * | 1975-03-22 | 1980-04-24 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Verfahren zur Herstellung von keimarmem, faserfreiem Pankreatin |
US3986927A (en) * | 1975-04-28 | 1976-10-19 | Armour Pharmaceutical Company | Process for the purification and sterilization of acidophilic biologicals by extreme acidification at cold temperatures |
GB1509866A (en) * | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
GB1590432A (en) * | 1976-07-07 | 1981-06-03 | Novo Industri As | Process for the production of an enzyme granulate and the enzyme granuate thus produced |
GB1603640A (en) * | 1977-07-20 | 1981-11-25 | Gist Brocades Nv | Enzyme particles |
JPS5535031A (en) | 1978-09-04 | 1980-03-11 | Shin Etsu Chem Co Ltd | Enteric coating composition |
US4259440A (en) | 1979-05-21 | 1981-03-31 | Miles Laboratories, Inc. | Hydrolysis and assay of triglycerides |
DE2923279B1 (de) * | 1979-06-08 | 1980-11-20 | Kali Chemie Pharma Gmbh | Verfahren zur Herstellung von Pankreatin-Pellets |
JPS5855125B2 (ja) | 1980-03-10 | 1983-12-08 | 信越化学工業株式会社 | 固形薬剤用腸溶性コ−テイング剤組成物 |
JPS57171428A (en) * | 1981-04-13 | 1982-10-22 | Sankyo Co Ltd | Preparation of coated solid preparation |
DE3377506D1 (en) * | 1982-12-30 | 1988-09-01 | Nordmark Arzneimittel Gmbh | Process for obtaining pancreatin |
US4447412A (en) * | 1983-02-01 | 1984-05-08 | Bilton Gerald L | Enzyme-containing digestive aid compostions |
IE55711B1 (en) | 1983-10-24 | 1990-12-19 | Bausch & Lomb | Improved method for enzymatic cleaning and disinfecting contact lenses |
US4490361A (en) * | 1983-12-02 | 1984-12-25 | Alpha Therapeutic Corporation | Virus inactivating heat treatment of plasma fractions |
DK263584D0 (da) | 1984-05-29 | 1984-05-29 | Novo Industri As | Enzymholdige granulater anvendt som detergentadditiver |
US4689297A (en) * | 1985-03-05 | 1987-08-25 | Miles Laboratories, Inc. | Dust free particulate enzyme formulation |
US4707287A (en) | 1985-06-28 | 1987-11-17 | The Procter & Gamble Company | Dry bleach stable enzyme composition |
US4775536A (en) * | 1986-02-24 | 1988-10-04 | Bristol-Myers Company | Enteric coated tablet and process for making |
DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
US5536661A (en) * | 1987-03-10 | 1996-07-16 | Novo Nordisk A/S | Process for the production of protein products in aspergillus |
US5766912A (en) * | 1986-03-17 | 1998-06-16 | Novo Nordisk A/S | Humicola lipase produced in aspergillus |
US5874558A (en) * | 1986-03-17 | 1999-02-23 | Novo Nordisk | Nucleic acid encoding a recombinant humicola sp. lipase |
GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
DE3764460D1 (de) | 1986-05-21 | 1990-09-27 | Novo Industri As | Herstellung eines ein enzym enthaltenden granulates und dessen verwendung in reinigungsmitteln. |
DE3642853A1 (de) | 1986-12-16 | 1988-06-23 | Ulrich Von Dr Ing Pidoll | Arzneimittel |
DK435587D0 (da) | 1987-08-21 | 1987-08-21 | Novo Industri As | Fremgangsmaade til fremstilling af et enzymholdigt granulat |
DK435687D0 (da) | 1987-08-21 | 1987-08-21 | Novo Industri As | Enzymholdigt granulat og fremgangsmaade til fremstilling deraf |
ATE125865T1 (de) | 1987-08-28 | 1995-08-15 | Novo Nordisk As | Rekombinante humicola-lipase und verfahren zur herstellung von rekombinanten humicola-lipasen. |
US5068110A (en) * | 1987-09-29 | 1991-11-26 | Warner-Lambert Company | Stabilization of enteric coated dosage form |
IL88961A (en) | 1988-01-29 | 1992-07-15 | Basf Ag | Stable mixtures containing oxidation-sensitive compounds |
WO1989008695A1 (en) | 1988-03-14 | 1989-09-21 | Novo-Nordisk A/S | Stabilized particulate composition |
DK78189D0 (da) | 1989-02-20 | 1989-02-20 | Novo Industri As | Enzymholdigt granulat og fremgangsmaade til fremstilling deraf |
DK78089D0 (da) | 1989-02-20 | 1989-02-20 | Novo Industri As | Detergentholdigt granulat og fremgangsmaade til fremstilling deraf |
US5219572A (en) * | 1989-03-17 | 1993-06-15 | Pitman-Moore, Inc. | Controlled release delivery device for macromolecular proteins |
JP3297433B2 (ja) * | 1989-06-15 | 2002-07-02 | ローヌ−プーラン ローラー インターナショナル (ホウルディングス) インコーポレイテッド | ウイルスで汚染された薬理組成物中のウイルスの不活性化方法 |
GB8915658D0 (en) | 1989-07-07 | 1989-08-23 | Unilever Plc | Enzymes,their production and use |
US5658871A (en) * | 1989-07-07 | 1997-08-19 | Lever Brothers Company, Division Of Conopco, Inc. | Microbial lipase muteins and detergent compositions comprising same |
WO1991006638A1 (en) | 1989-10-31 | 1991-05-16 | Genencor International, Inc. | Dust-free coated enzyme formulation |
GB9007052D0 (en) | 1990-03-29 | 1990-05-30 | Skua Investments Ltd | Pharmaceutical formulations |
US6187572B1 (en) * | 1990-04-16 | 2001-02-13 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants |
DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
US5618710A (en) * | 1990-08-03 | 1997-04-08 | Vertex Pharmaceuticals, Inc. | Crosslinked enzyme crystals |
US5801022A (en) * | 1990-08-03 | 1998-09-01 | Vertex Pharmaceuticals, Incorporated | Method of producing a product with crosslinked crystals of thermolysin |
IE912767A1 (en) | 1990-08-03 | 1992-02-12 | Vertex Pharma | Use of crosslinked crystals as a novel form of enzyme¹immobilization |
US5869438A (en) * | 1990-09-13 | 1999-02-09 | Novo Nordisk A/S | Lipase variants |
CA2055572A1 (en) * | 1990-12-18 | 1992-06-19 | David Kronenthal | Processes and intermediates for thromboxane receptor antagonists |
US5254283A (en) | 1991-01-17 | 1993-10-19 | Genencor International, Inc. | Isophthalic polymer coated particles |
ZA92452B (en) * | 1991-01-24 | 1992-10-28 | Martek Corp | Microbial oil mixtures and uses thereof |
DK13491D0 (da) | 1991-01-25 | 1991-01-25 | Novo Nordisk As | Anvendelse af et enzymholdigt granulat og fremgangsmaade til fremstilling af et forderstof i tabletform |
DE4203315A1 (de) | 1991-02-14 | 1992-08-20 | Kali Chemie Pharma Gmbh | Verfahren zur gewinnung von pankreatin |
WO1993000924A1 (de) | 1991-07-01 | 1993-01-21 | Basf Aktiengesellschaft | Verwendung von lipasen zur herstellung von arzneimitteln |
US5225202A (en) * | 1991-09-30 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Enteric coated pharmaceutical compositions |
US5324649A (en) * | 1991-10-07 | 1994-06-28 | Genencor International, Inc. | Enzyme-containing granules coated with hydrolyzed polyvinyl alcohol or copolymer thereof |
US5879920A (en) * | 1991-10-07 | 1999-03-09 | Genencor International, Inc. | Coated enzyme-containing granule |
WO1993007260A1 (en) | 1991-10-10 | 1993-04-15 | Genencor International, Inc. | Process for dust-free enzyme manufacture |
DE4200002A1 (de) | 1992-01-02 | 1993-07-08 | Rudolf V Dipl Chem Dr Noronha | Reinigungstablette fuer die zahnprothesen |
US5302400A (en) * | 1992-06-22 | 1994-04-12 | Digestive Care Inc. | Preparation of gastric acid-resistant microspheres containing digestive enzymes and buffered-bile acids |
US5260074A (en) * | 1992-06-22 | 1993-11-09 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
DE4227385A1 (de) * | 1992-08-19 | 1994-02-24 | Kali Chemie Pharma Gmbh | Pankreatinmikropellets |
JPH08502492A (ja) | 1992-10-16 | 1996-03-19 | スミスクライン・ビーチャム・コーポレイション | 治療用ミクロエマルジョン |
WO1994008603A1 (en) | 1992-10-16 | 1994-04-28 | Smithkline Beecham Corporation | Compositions |
JP3264027B2 (ja) * | 1993-02-24 | 2002-03-11 | ソニー株式会社 | 放電セル及びその製造方法 |
DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
DE4322229A1 (de) | 1993-07-05 | 1995-01-12 | Cognis Bio Umwelt | Umhüllte Enzymzubereitung für Wasch- und Reinigungsmittel |
EP0719133A1 (en) | 1993-09-15 | 1996-07-03 | Unilever Plc | Skin care method and composition |
US6312704B1 (en) * | 1993-09-30 | 2001-11-06 | Gattefosse, S.A. | Orally administrable composition capable of providing enhanced bioavailability when ingested |
FR2710535B1 (fr) | 1993-09-30 | 1995-11-24 | Gattefosse Ets Sa | Composition à usage pharmaceutique ou cosmétique apte à former une microémulsion. |
US6054136A (en) * | 1993-09-30 | 2000-04-25 | Gattefosse S.A. | Orally administrable composition capable of providing enhanced bioavailability when ingested |
DE4344215A1 (de) | 1993-12-23 | 1995-06-29 | Cognis Bio Umwelt | Silberkorrosionsschutzmittelhaltige Enzymzubereitung |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
DE4422198C2 (de) | 1994-06-24 | 1997-08-28 | Audi Ag | Verfahren zum Steuern der elektrischen Beheizung eines Katalysators |
JP3355593B2 (ja) * | 1994-08-19 | 2002-12-09 | 信越化学工業株式会社 | 固形腸溶製剤の製造方法 |
WO1996016151A1 (en) | 1994-11-18 | 1996-05-30 | Genencor International, Inc. | Coated enzyme granules |
CN1092236C (zh) | 1995-05-29 | 2002-10-09 | 花王株式会社 | 含酶粒状物及其制备方法 |
ES2236738T3 (es) | 1995-05-31 | 2005-07-16 | Medzyme N.V. | Composicion para mejorar la digestibilidad y la utilizacion de nutrientes. |
AU1200997A (en) | 1995-12-22 | 1997-07-17 | Helix Biotechnology Ltd | Thermostable proteolytic enzyme from thermoactinomyces thalpophilus thm1 |
ATE291082T1 (de) | 1996-04-12 | 2005-04-15 | Novozymes As | Enzymhaltige granulatkörner sowie verfahren zu deren herstellung |
ID18663A (id) * | 1996-04-12 | 1998-04-30 | Novartis Ag | Komposisi farmasi berlapis enterik |
DE69737828T2 (de) * | 1996-04-29 | 2008-03-06 | Novozymes A/S | Flüssige, nichtwässrige enzyme enthaltende zusammensetzungen |
US5750104A (en) * | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
GB9613858D0 (en) | 1996-07-02 | 1996-09-04 | Cortecs Ltd | Hydrophobic preparations |
DE19724845A1 (de) * | 1996-08-28 | 1998-03-05 | Solvay Pharm Gmbh | Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen |
GB9624927D0 (en) * | 1996-11-29 | 1997-01-15 | Oxford Glycosciences Uk Ltd | Gels and their use |
US6140475A (en) | 1997-04-11 | 2000-10-31 | Altus Biologics Inc. | Controlled dissolution crosslinked protein crystals |
AUPO693397A0 (en) | 1997-05-22 | 1997-06-12 | Betatene Limited | Carotenoid formulation |
NZ330940A (en) | 1997-07-24 | 2000-02-28 | F | Production of consensus phytases from fungal origin using computer programmes |
ES2137862B1 (es) | 1997-07-31 | 2000-09-16 | Intexim S A | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
JP3611456B2 (ja) * | 1997-09-30 | 2005-01-19 | 日研化学株式会社 | テオフィリン徐放性錠剤 |
KR19990072826A (ko) | 1998-02-26 | 1999-09-27 | 우재영 | 판크레아틴장용코팅과립의제조방법 |
FR2775597B1 (fr) | 1998-03-04 | 2001-04-20 | Gattefosse Ets Sa | Pellet administrable par voie orale apte a ameliorer la biodisponibilite de la substance active, procede de fabrication |
US20030021844A1 (en) * | 1998-03-04 | 2003-01-30 | Philippe Barthelemy | Immediate-release oral pellet comprising polyglycolysed glycerides, and manufacturing process |
JP2002506013A (ja) * | 1998-03-09 | 2002-02-26 | イスタ ファーマシューティカルズ インコーポレイテッド | 酵素角膜矯正術における角膜硬化剤の使用 |
DE29824797U1 (de) | 1998-05-22 | 2002-08-22 | Bristol Myers Squibb Co | Magensaftresistent überzogene Arzneimittel |
UA69413C2 (uk) * | 1998-05-22 | 2004-09-15 | Брістол-Майерс Сквібб Компані | Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції |
US6268329B1 (en) * | 1998-06-30 | 2001-07-31 | Nouozymes A/S | Enzyme containing granule |
DK1092007T3 (da) | 1998-06-30 | 2004-04-05 | Novozymes As | Ny forbedret enzymholdig granule |
DE19848849A1 (de) | 1998-10-22 | 2000-04-27 | Knoll Ag | Verfahren zur Herstellung von festen, sphärischen Formen, enthaltend eine biologisch aktive Substanz |
DE19856415C2 (de) | 1998-12-08 | 2001-06-07 | Thomas Fenner | Verfahren zur Reinigung bzw. Isolierung viraler Nukleinsäuren |
US20030104048A1 (en) * | 1999-02-26 | 2003-06-05 | Lipocine, Inc. | Pharmaceutical dosage forms for highly hydrophilic materials |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
CZ20013345A3 (cs) | 1999-03-17 | 2002-01-16 | Solvay Pharmaceuticals Gmbh | Léčivo k léčení diabetu |
DE60034885T2 (de) | 1999-05-27 | 2008-01-17 | Amano Enzyme Inc., Nagoya | Enzymlauge und verfahren zu deren herstellung, enzymzubereitung, proteasezubereitungen und proteaseproduzierendes bakterium |
AU7405400A (en) | 1999-10-01 | 2001-05-10 | Novozymes A/S | Enzyme granulate |
CN1171639C (zh) | 1999-10-12 | 2004-10-20 | 第一三得利制药株式会社 | 口服药物组合物 |
CZ299726B6 (cs) * | 1999-11-01 | 2008-11-05 | Lécivo pro lécení zácpy a syndromu dráždivého tracníku | |
US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
ES2248273T3 (es) * | 1999-12-30 | 2006-03-16 | Kemin Industries, Inc. | Procedimiento para reducir la cantidad de enzimas. |
CA2395343C (en) | 2000-02-08 | 2009-06-30 | F. Hoffmann-La Roche Ag | Use of acid-stable proteases in animal feed |
US20010046493A1 (en) * | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
KR20010100194A (ko) | 2000-03-13 | 2001-11-14 | 박호군 | 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법 |
DE10026698A1 (de) * | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
US20020146451A1 (en) * | 2000-07-15 | 2002-10-10 | Sharma Virender K. | Method for the administration of acid-labile drugs |
EP1317533A1 (en) | 2000-09-08 | 2003-06-11 | Novozymes A/S | Lubricated granules |
AU2001291647A1 (en) | 2000-10-02 | 2002-04-15 | Novozymes A/S | Coated particles containing an active substance |
AU2002223666B2 (en) * | 2000-11-02 | 2006-08-24 | Cilian Ag | Use of enzymes obtained from ciliates as medicaments for promoting digestion |
IT1319655B1 (it) * | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
AR032392A1 (es) * | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
US6692771B2 (en) * | 2001-02-23 | 2004-02-17 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
US6676933B2 (en) * | 2001-05-23 | 2004-01-13 | Osmotica Corp. | Pharmaceutical composition containing mosapride and pancreatin |
ATE346590T1 (de) | 2001-07-26 | 2006-12-15 | Ethypharm Sa | Umgehüllte allylamine oder benzylamine enthaltende granulate, verfahren zur herstellung und in der mundhöhle dispergierbare tabletten enthaltend die umgehüllten granulate |
FR2827770B1 (fr) * | 2001-07-27 | 2005-08-19 | Gattefosse Ets Sa | Composition pharmaceutique a usage oral comprenant un principe actif susceptible de subir un important effet de premier passage intestinal |
US6749851B2 (en) * | 2001-08-31 | 2004-06-15 | Clearant, Inc. | Methods for sterilizing preparations of digestive enzymes |
HUP0501186A2 (en) | 2001-12-03 | 2006-05-29 | Novacea | Pharmaceutical compositions comprising active vitamin d compounds |
AU2002351749A1 (en) | 2001-12-21 | 2003-07-15 | Novozymes A/S | Salt coatings |
AU2003214037A1 (en) | 2002-03-27 | 2003-10-08 | Novozymes A/S | Granules with filamentous coatings |
US20040161423A1 (en) * | 2002-07-18 | 2004-08-19 | Sanjeev Kumar (Mendiratta) | Polymer modified anti-angiogenic serpins |
JP2007506405A (ja) | 2003-02-06 | 2007-03-22 | ノボザイムス アクティーゼルスカブ | 糸状菌におけるヒトh鎖抗体の発現 |
US20040213847A1 (en) * | 2003-04-23 | 2004-10-28 | Matharu Amol Singh | Delayed release pharmaceutical compositions containing proton pump inhibitors |
CN1809753B (zh) * | 2003-07-29 | 2010-10-20 | 索尔瓦药物有限公司 | 通过二维凝胶电泳分析包含生理可接受消化酶混合物的方法 |
EP1711529A1 (en) | 2004-01-21 | 2006-10-18 | Novozymes A/S | Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell |
ITMI20040891A1 (it) | 2004-05-04 | 2004-08-04 | Ibsa Inst Biochimique Sa | Nuovo metodo per la partizione ed inattivazione di contaminanti virali e prionici |
EP1809320B1 (en) | 2004-10-14 | 2010-07-21 | Altus Pharmaceuticals Inc. | Compositions containing lipase; protease and amylase for treating pancreatic insufficiency |
AU2006261442A1 (en) | 2005-06-24 | 2006-12-28 | Novozymes A/S | Lipases for pharmaceutical use |
RU2413532C2 (ru) | 2005-07-29 | 2011-03-10 | Зольвай Фармасьютиклз Гмбх | Способ получения стерилизованного порошкообразного панкреатина |
ATE418329T1 (de) | 2005-08-15 | 2009-01-15 | Solvay Pharm Gmbh | Pankreatin-mikropellets geeignet für magensaftresistente überzüge |
US11266607B2 (en) * | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US9198871B2 (en) * | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US10072256B2 (en) * | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
CN105112386A (zh) | 2006-12-21 | 2015-12-02 | 诺维信公司 | 用于药物用途的脂肪酶变体 |
US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
US10087493B2 (en) * | 2008-03-07 | 2018-10-02 | Aptalis Pharma Canada Ulc | Method for detecting infectious parvovirus in pharmaceutical preparations |
-
2005
- 2005-03-21 ES ES05733481T patent/ES2314646T3/es active Active
- 2005-03-21 AT AT05733481T patent/ATE407693T1/de active
- 2005-03-21 AU AU2005227090A patent/AU2005227090B2/en active Active
- 2005-03-21 PT PT05733481T patent/PT1729797E/pt unknown
- 2005-03-21 DE DE602005009677T patent/DE602005009677D1/de active Active
- 2005-03-21 RU RU2006137325/15A patent/RU2381813C2/ru active
- 2005-03-21 CA CA2560613A patent/CA2560613C/en active Active
- 2005-03-21 PL PL05733481T patent/PL1729797T3/pl unknown
- 2005-03-21 BR BRPI0509148A patent/BRPI0509148B8/pt active IP Right Grant
- 2005-03-21 EP EP05733481A patent/EP1729797B1/en active Active
- 2005-03-21 CN CN2005800093147A patent/CN1933850B/zh active Active
- 2005-03-21 JP JP2007504411A patent/JP5032300B2/ja active Active
- 2005-03-21 WO PCT/EP2005/051295 patent/WO2005092370A1/en active IP Right Grant
- 2005-03-22 US US11/085,073 patent/US8802087B2/en active Active
-
2007
- 2007-06-07 HK HK07106104.3A patent/HK1101342A1/xx unknown
-
2014
- 2014-06-18 US US14/308,543 patent/US20140302000A1/en not_active Abandoned
-
2019
- 2019-05-23 US US16/421,068 patent/US20190275122A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE407693T1 (de) | 2008-09-15 |
HK1101342A1 (en) | 2007-10-18 |
JP2007530503A (ja) | 2007-11-01 |
US20050250817A1 (en) | 2005-11-10 |
CN1933850B (zh) | 2011-01-12 |
CA2560613C (en) | 2015-11-24 |
BRPI0509148B1 (pt) | 2016-07-12 |
RU2381813C2 (ru) | 2010-02-20 |
BRPI0509148A (pt) | 2007-09-11 |
AU2005227090B2 (en) | 2010-12-09 |
PT1729797E (pt) | 2008-12-17 |
CN1933850A (zh) | 2007-03-21 |
DE602005009677D1 (de) | 2008-10-23 |
AU2005227090A1 (en) | 2005-10-06 |
RU2006137325A (ru) | 2008-04-27 |
PL1729797T3 (pl) | 2009-02-27 |
WO2005092370A1 (en) | 2005-10-06 |
US8802087B2 (en) | 2014-08-12 |
ES2314646T3 (es) | 2009-03-16 |
EP1729797B1 (en) | 2008-09-10 |
EP1729797A1 (en) | 2006-12-13 |
US20140302000A1 (en) | 2014-10-09 |
CA2560613A1 (en) | 2005-10-06 |
US20190275122A1 (en) | 2019-09-12 |
JP5032300B2 (ja) | 2012-09-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0509148B8 (pt) | composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina contendo tensoativos, seus usos e respectivos processos de fabricação | |
NO20033261L (no) | Nye blandinger av mikrobielle enzymer | |
ES2542350T3 (es) | Composición detergente para lavavajillas | |
Queiroz et al. | Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus | |
BRPI0510817A (pt) | protease, uso de uma protease, composição farmacêutica, e, método para o tratamento de uma doença | |
WO2008021987A3 (en) | Proteolytic enzyme formulations | |
NO20080437L (no) | Lipaser til farmasoytisk anvendelse | |
NL300874I2 (nl) | Elosulfase alfa | |
NO20092729L (no) | Lipasevarianter for farmasoytisk anvendelse | |
WO2007053619A3 (en) | A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency | |
ES2572160T3 (es) | Una nueva preparación farmacéutica para preeclampsia | |
NO20085243L (no) | Farmasoytisk sammensetning til behandling av virusinfeksjoner og/eller tumorsykdommer gjennom inhibering av proteinfolding og Proteinnedbryting | |
Rucavado et al. | Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom | |
BRPI0511835A (pt) | enzima lipolìtica e seus usos na indústria alimentìcia | |
BR112014016557A2 (pt) | métodos de tratamento de sintomas comportamentais de distúrbios neurológicos e mentais | |
NO20076675L (no) | Aminopiperidinquinoliner og deres azaisosteriske analoger med antibakteriell aktivitet | |
WO2011007194A8 (en) | Tray for positioning elongated objects, in particular syringe bodies or syringes | |
WO2002076939A3 (en) | Cysteine protease inhibitors | |
BR112014031273A2 (pt) | compostos enzima alvejados e seus usos | |
CL2012000658A1 (es) | Composicion farmaceutica que comprende microesferas entericamente recubiertas que contienen enzimas digestivas tal como lipasa y microesferas no recubiertas entericamente que contienen enzimas digestivas tal como proteasa; forma de dosis; y su uso tratar el dolor de pancreatitis e insuficiencia pancreatica. | |
WO2006017124A3 (en) | Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases | |
EA201070826A1 (ru) | Антитела против pcrv | |
FR2896693B1 (fr) | Composition comprenant plusieurs toxines botuliques | |
DK1330262T3 (da) | Anvendelse af enzymer udvundet fra ciliater som lægemidler til fremme af fordöjelsen | |
CL2008001279A1 (es) | Metodo para mejorar la actividad antimicrobiana de una formulacion que comprende un aminoacido n-halogenado que comprende un agente de transferencia de fase; formulacion; metodo para desinfectar superficies y lentes de contacto; metodo para tratar una infeccion de tejido y para tratar infecciones respiratorias. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: ABBOTT PRODUCTS GMBH (DE) |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/07/2016, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/03/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |