ATE407693T1 - Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin,mit tensiden - Google Patents

Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin,mit tensiden

Info

Publication number
ATE407693T1
ATE407693T1 AT05733481T AT05733481T ATE407693T1 AT E407693 T1 ATE407693 T1 AT E407693T1 AT 05733481 T AT05733481 T AT 05733481T AT 05733481 T AT05733481 T AT 05733481T AT E407693 T1 ATE407693 T1 AT E407693T1
Authority
AT
Austria
Prior art keywords
pharmaceutical compositions
lipase
pancreatin
oral pharmaceutical
surfactants
Prior art date
Application number
AT05733481T
Other languages
English (en)
Inventor
George Shlieout
Bernd Boedecker
Siegfried Schaefer
Bernd Thumbeck
Peter-Colin Gregory
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04101164.4A external-priority patent/EP1579869A1/de
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Application granted granted Critical
Publication of ATE407693T1 publication Critical patent/ATE407693T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/745—Polymers of hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT05733481T 2004-03-22 2005-03-21 Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin,mit tensiden ATE407693T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55499304P 2004-03-22 2004-03-22
EP04101164.4A EP1579869A1 (de) 2004-03-22 Pharmazeutische Zusammensetzung enthaltend Lipase, insbesondere Pankreatin, und Tenside

Publications (1)

Publication Number Publication Date
ATE407693T1 true ATE407693T1 (de) 2008-09-15

Family

ID=34964300

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05733481T ATE407693T1 (de) 2004-03-22 2005-03-21 Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin,mit tensiden

Country Status (14)

Country Link
US (3) US8802087B2 (de)
EP (1) EP1729797B1 (de)
JP (1) JP5032300B2 (de)
CN (1) CN1933850B (de)
AT (1) ATE407693T1 (de)
AU (1) AU2005227090B2 (de)
BR (1) BRPI0509148B8 (de)
CA (1) CA2560613C (de)
DE (1) DE602005009677D1 (de)
ES (1) ES2314646T3 (de)
PL (1) PL1729797T3 (de)
PT (1) PT1729797E (de)
RU (1) RU2381813C2 (de)
WO (1) WO2005092370A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
JP5140586B2 (ja) 2005-07-29 2013-02-06 アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング 滅菌パンクレアチン粉末の製法
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
DE102006001554A1 (de) * 2006-01-05 2007-07-12 Ipc Process-Center Gmbh & Co. Micropellets für die Herstellung von Tiernahrungspellets
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
KR20090101930A (ko) 2006-12-21 2009-09-29 노보자임스 에이/에스 약학적 사용을 위한 리파아제 변형체
CN101686943B (zh) 2007-02-20 2014-03-26 阿普塔利斯制药有限公司 稳定的消化酶组合物
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
US10087493B2 (en) 2008-03-07 2018-10-02 Aptalis Pharma Canada Ulc Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
US11016104B2 (en) 2008-07-01 2021-05-25 Curemark, Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US10776453B2 (en) 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
EP2165717A1 (de) 2008-08-27 2010-03-24 Nordmark Arzneimittel GmbH & Co.KG Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte
WO2010080830A1 (en) 2009-01-06 2010-07-15 Curemark Llc Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces
KR20170005191A (ko) 2009-01-06 2017-01-11 큐어론 엘엘씨 이. 콜라이에 의한 구강 감염의 치료 또는 예방을 위한 조성물 및 방법
HRP20140715T1 (hr) * 2009-01-29 2014-09-26 Nordmark Arzneimittel Gmbh & Co.Kg Farmaceutski preparat koji sadrži lipazu bakterijskog porijekla
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
EP2440210A4 (de) 2009-06-12 2014-01-29 Meritage Pharma Inc Verfahren zur behandlung von magen-darm-erkrankungen
PL2295039T5 (pl) * 2009-08-28 2023-02-27 Nordmark Pharma Gmbh Sposób wytwarzania granulek zawierających pankreatynę, w szczególności mikrogranulek zawierających pankreatynę, oraz wytworzone tym sposobem granulki zawierające pankreatynę
US8784884B2 (en) 2009-09-17 2014-07-22 Stephen Perrett Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency
CN103221036A (zh) 2010-10-01 2013-07-24 阿普塔利斯制药有限公司 肠溶包衣的低强度胰脂肪酶制剂
EP2489349B1 (de) 2011-02-17 2014-05-28 Nordmark Arzneimittel GmbH & Co.KG Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und Verfahren zu deren Herstellung
EP2701733B1 (de) 2011-04-21 2019-04-03 Curemark, LLC Verbindungen zur behandlung neuropsychiatrischer störungen
KR101953413B1 (ko) 2011-08-08 2019-02-28 앨러간 파마슈티컬스 인터내셔널 리미티드 소화효소들을 함유하는 고형 조성물들의 용해 시험 방법
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
AU2013206890B2 (en) * 2012-01-03 2017-09-28 Curemark, Llc Methods of treating behavioral symptoms of neurological and mental disorders
US9668474B2 (en) 2012-02-10 2017-06-06 Stepan Company Structured surfactant suspending systems
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
SG11201505247TA (en) * 2013-01-14 2015-08-28 Infirst Healthcare Ltd Solid solution compositions and use in cardiovascular disease
ES2784227T3 (es) 2013-08-09 2020-09-23 Allergan Pharmaceuticals Int Ltd Composición de enzimas digestivos adecuada para la administración entérica
JP2014193909A (ja) * 2014-06-04 2014-10-09 Nordmark Arzneimittel Gmbh & Co Kg 医薬調製物
EP3157568A1 (de) 2014-06-19 2017-04-26 Aptalis Pharma Limited Verfahren zur entfernung von viralen verunreinigungen aus pankreatischen extrakten
US20160120964A1 (en) * 2014-11-05 2016-05-05 George Shlieout Processes for producing compositions with improved safety profile having lipase activity and compositions suitable for pharmaceutical use
US10739353B2 (en) * 2014-12-31 2020-08-11 Signpath Pharma, Inc. Suppression of cytokine release and cytokine storm
US20180028454A1 (en) * 2015-02-04 2018-02-01 Abbvie Inc. Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency
CN104730014B (zh) * 2015-03-27 2017-08-04 宁波博泰生物技术有限公司 一种血清脂肪酶测定试剂盒及其制备方法
DE102015114862A1 (de) * 2015-09-04 2017-03-09 Nordmark Arzneimittel Gmbh & Co. Kg Pharmazeutische Zusammensetzung, enthaltend eine bakterielle Lipase
CA3050082A1 (en) 2016-04-04 2017-10-12 Omeza LLC Fish oil topical composition
US10836890B2 (en) * 2017-01-25 2020-11-17 Nano And Advanced Materials Institute Limited Mechanically reinforced, transparent, anti-biofouling thermoplastic resin composition and manufacturing method thereof
DE102017104472A1 (de) 2017-03-03 2018-09-06 Nordmark Arzneimittel Gmbh & Co. Kg Schmelztablette enthaltend Burlulipase und daraus hergestellte pharmazeutische Zusammensetzung
DE102017104482A1 (de) * 2017-03-03 2018-09-06 Nordmark Arzneimittel Gmbh & Co. Kg Pharmazeutische Zusammensetzung umfassend Pankreatin und einen lipasehaltigen Überzug
AU2018250823A1 (en) 2017-04-10 2019-10-17 Curemark, Llc Compositions for treating addiction
CN110075279A (zh) * 2019-04-25 2019-08-02 淮安麦德森制药有限公司 胰酶微球及其生产方法
RU2706003C1 (ru) * 2019-09-09 2019-11-13 Акционерное общество "АВВА РУС" Микрогранулы, содержащие панкреатин
US20210236629A1 (en) * 2020-02-05 2021-08-05 Jubilant Pharma Holdings Inc. Self-emulsifying dosage forms of allergen and their preparation thereof
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses
EP4082518A1 (de) * 2021-04-28 2022-11-02 Cnce Innovacion, S.L. Fettsäurezusammensetzungen zur behandlung und vorbeugung von haarausfall und alopezie
CA3241218A1 (en) * 2021-12-16 2023-06-22 Dinesh SRINIVASAN Stable lipase formulations and methods thereof

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3324002A (en) * 1962-09-17 1967-06-06 Armour Pharma Anti-inflammatory preparations containing proteolytic enzymes and adrenal glucocorticoids
US3803305A (en) * 1962-12-28 1974-04-09 Rolland A Lab Process for obtaining extracts from pancreas
US3956483A (en) * 1968-10-24 1976-05-11 Wilson Pharmaceutical & Chemical Corporation Preparing pancreatin
DE2035739A1 (en) 1970-07-18 1972-01-27 Röhm FmbH, 6100 Darmstadt Oral enzyme prepsn - consisting of granulate with gastric juices-resistant coating in tablet or capsule form
US3991180A (en) * 1972-03-06 1976-11-09 Rohm And Haas Company Stabilization of internally administered pancreatic lipase
FR2183546B1 (de) * 1972-05-10 1975-06-20 Servier Lab
DE2410241A1 (de) 1974-03-04 1975-09-18 Christian Brunnengraeber Chem Granulataehnliche darreichungsform fuer arzneimittel
DE2512746C3 (de) 1975-03-22 1980-04-24 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur Herstellung von keimarmem, faserfreiem Pankreatin
US3986927A (en) * 1975-04-28 1976-10-19 Armour Pharmaceutical Company Process for the purification and sterilization of acidophilic biologicals by extreme acidification at cold temperatures
GB1509866A (en) 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
GB1590432A (en) * 1976-07-07 1981-06-03 Novo Industri As Process for the production of an enzyme granulate and the enzyme granuate thus produced
GB1603640A (en) * 1977-07-20 1981-11-25 Gist Brocades Nv Enzyme particles
JPS5535031A (en) 1978-09-04 1980-03-11 Shin Etsu Chem Co Ltd Enteric coating composition
US4259440A (en) 1979-05-21 1981-03-31 Miles Laboratories, Inc. Hydrolysis and assay of triglycerides
DE2923279C2 (de) 1979-06-08 1987-07-09 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur Herstellung von Pankreatin-Pellets und diese enthaltende Arzneimittel
JPS5855125B2 (ja) 1980-03-10 1983-12-08 信越化学工業株式会社 固形薬剤用腸溶性コ−テイング剤組成物
JPS57171428A (en) * 1981-04-13 1982-10-22 Sankyo Co Ltd Preparation of coated solid preparation
EP0115023B1 (de) * 1982-12-30 1988-07-27 Nordmark Arzneimittel GmbH Verfahren zur Gewinnung von Pankreatin
US4447412A (en) * 1983-02-01 1984-05-08 Bilton Gerald L Enzyme-containing digestive aid compostions
IE55711B1 (en) 1983-10-24 1990-12-19 Bausch & Lomb Improved method for enzymatic cleaning and disinfecting contact lenses
US4490361A (en) * 1983-12-02 1984-12-25 Alpha Therapeutic Corporation Virus inactivating heat treatment of plasma fractions
DK263584D0 (da) 1984-05-29 1984-05-29 Novo Industri As Enzymholdige granulater anvendt som detergentadditiver
US4689297A (en) * 1985-03-05 1987-08-25 Miles Laboratories, Inc. Dust free particulate enzyme formulation
US4707287A (en) 1985-06-28 1987-11-17 The Procter & Gamble Company Dry bleach stable enzyme composition
US4775536A (en) * 1986-02-24 1988-10-04 Bristol-Myers Company Enteric coated tablet and process for making
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
US5766912A (en) * 1986-03-17 1998-06-16 Novo Nordisk A/S Humicola lipase produced in aspergillus
US5536661A (en) * 1987-03-10 1996-07-16 Novo Nordisk A/S Process for the production of protein products in aspergillus
US5874558A (en) * 1986-03-17 1999-02-23 Novo Nordisk Nucleic acid encoding a recombinant humicola sp. lipase
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
DE3764460D1 (de) 1986-05-21 1990-09-27 Novo Industri As Herstellung eines ein enzym enthaltenden granulates und dessen verwendung in reinigungsmitteln.
DE3642853A1 (de) 1986-12-16 1988-06-23 Ulrich Von Dr Ing Pidoll Arzneimittel
DK435587D0 (da) 1987-08-21 1987-08-21 Novo Industri As Fremgangsmaade til fremstilling af et enzymholdigt granulat
DK435687D0 (da) 1987-08-21 1987-08-21 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
ES2076939T3 (es) 1987-08-28 1995-11-16 Novo Nordisk As Lipasa recombinante de humicola y procedimiento para la produccion de lipasas recombinantes de humicola.
US5068110A (en) * 1987-09-29 1991-11-26 Warner-Lambert Company Stabilization of enteric coated dosage form
IL88961A (en) * 1988-01-29 1992-07-15 Basf Ag Stable mixtures containing oxidation-sensitive compounds
EP0404806B1 (de) 1988-03-14 1992-03-11 Novo Nordisk A/S Stabilisierte teilchenzusammensetzung
DK78089D0 (da) 1989-02-20 1989-02-20 Novo Industri As Detergentholdigt granulat og fremgangsmaade til fremstilling deraf
DK78189D0 (da) 1989-02-20 1989-02-20 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
US5219572A (en) * 1989-03-17 1993-06-15 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
DK0431129T3 (da) * 1989-06-15 1996-06-17 Rorer Int Overseas Fremgangsmåder til inaktivering af virus i viruskontaminerede farmaceutiske præparater
US5658871A (en) * 1989-07-07 1997-08-19 Lever Brothers Company, Division Of Conopco, Inc. Microbial lipase muteins and detergent compositions comprising same
GB8915658D0 (en) 1989-07-07 1989-08-23 Unilever Plc Enzymes,their production and use
WO1991006638A1 (en) 1989-10-31 1991-05-16 Genencor International, Inc. Dust-free coated enzyme formulation
GB9007052D0 (en) 1990-03-29 1990-05-30 Skua Investments Ltd Pharmaceutical formulations
US6187572B1 (en) * 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
DK173590D0 (da) 1990-06-06 1990-07-19 Novo Nordisk As Rekombinante terapeutiske lipaser
US5801022A (en) * 1990-08-03 1998-09-01 Vertex Pharmaceuticals, Incorporated Method of producing a product with crosslinked crystals of thermolysin
US5618710A (en) * 1990-08-03 1997-04-08 Vertex Pharmaceuticals, Inc. Crosslinked enzyme crystals
ATE323158T1 (de) 1990-08-03 2006-04-15 Vertex Pharma Verwendung von vernetzten kristallen als neue form von immobilisierung von enzymen
US5869438A (en) * 1990-09-13 1999-02-09 Novo Nordisk A/S Lipase variants
CA2055572A1 (en) * 1990-12-18 1992-06-19 David Kronenthal Processes and intermediates for thromboxane receptor antagonists
US5254283A (en) 1991-01-17 1993-10-19 Genencor International, Inc. Isophthalic polymer coated particles
ATE200619T1 (de) * 1991-01-24 2001-05-15 Martek Corp Mikrobielle öle und ihre verwendungen
DK13491D0 (da) 1991-01-25 1991-01-25 Novo Nordisk As Anvendelse af et enzymholdigt granulat og fremgangsmaade til fremstilling af et forderstof i tabletform
DE4203315A1 (de) 1991-02-14 1992-08-20 Kali Chemie Pharma Gmbh Verfahren zur gewinnung von pankreatin
WO1993000924A1 (de) 1991-07-01 1993-01-21 Basf Aktiengesellschaft Verwendung von lipasen zur herstellung von arzneimitteln
US5225202A (en) * 1991-09-30 1993-07-06 E. R. Squibb & Sons, Inc. Enteric coated pharmaceutical compositions
US5324649A (en) * 1991-10-07 1994-06-28 Genencor International, Inc. Enzyme-containing granules coated with hydrolyzed polyvinyl alcohol or copolymer thereof
US5879920A (en) * 1991-10-07 1999-03-09 Genencor International, Inc. Coated enzyme-containing granule
WO1993007260A1 (en) 1991-10-10 1993-04-15 Genencor International, Inc. Process for dust-free enzyme manufacture
DE4200002A1 (de) 1992-01-02 1993-07-08 Rudolf V Dipl Chem Dr Noronha Reinigungstablette fuer die zahnprothesen
US5302400A (en) * 1992-06-22 1994-04-12 Digestive Care Inc. Preparation of gastric acid-resistant microspheres containing digestive enzymes and buffered-bile acids
US5260074A (en) * 1992-06-22 1993-11-09 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
DE4227385A1 (de) 1992-08-19 1994-02-24 Kali Chemie Pharma Gmbh Pankreatinmikropellets
EP0671929A4 (de) 1992-10-16 1996-09-25 Smithkline Beecham Corp Zusammensetzungen.
EP0666752A4 (de) 1992-10-16 1996-09-11 Smithkline Beecham Corp Therapeutische mikroemulsionen.
JP3264027B2 (ja) * 1993-02-24 2002-03-11 ソニー株式会社 放電セル及びその製造方法
DK39693D0 (da) 1993-04-02 1993-04-02 Novo Nordisk As Enzym
DE4322229A1 (de) * 1993-07-05 1995-01-12 Cognis Bio Umwelt Umhüllte Enzymzubereitung für Wasch- und Reinigungsmittel
AU7656894A (en) 1993-09-15 1995-04-03 Unilever Plc Skin care method and composition
US6054136A (en) * 1993-09-30 2000-04-25 Gattefosse S.A. Orally administrable composition capable of providing enhanced bioavailability when ingested
FR2710535B1 (fr) * 1993-09-30 1995-11-24 Gattefosse Ets Sa Composition à usage pharmaceutique ou cosmétique apte à former une microémulsion.
US6312704B1 (en) * 1993-09-30 2001-11-06 Gattefosse, S.A. Orally administrable composition capable of providing enhanced bioavailability when ingested
DE4344215A1 (de) 1993-12-23 1995-06-29 Cognis Bio Umwelt Silberkorrosionsschutzmittelhaltige Enzymzubereitung
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
DE4422198C2 (de) 1994-06-24 1997-08-28 Audi Ag Verfahren zum Steuern der elektrischen Beheizung eines Katalysators
JP3355593B2 (ja) * 1994-08-19 2002-12-09 信越化学工業株式会社 固形腸溶製剤の製造方法
ATE198765T1 (de) 1994-11-18 2001-02-15 Genencor Int Umhüllte enzymgranulate
US5851975A (en) 1995-05-29 1998-12-22 Kao Corporation Enzyme-containing granulated substance and preparation process thereof
US6051220A (en) * 1995-05-31 2000-04-18 Medzyme N.V. And Simon Lodewijk Scharpe Composition to improve digestibility and utilization of nutrients
AU1200997A (en) 1995-12-22 1997-07-17 Helix Biotechnology Ltd Thermostable proteolytic enzyme from thermoactinomyces thalpophilus thm1
AU2568797A (en) 1996-04-12 1997-11-07 Novo Nordisk A/S Enzyme-containing granules and process for the production thereof
ID18663A (id) * 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
WO1997041215A1 (en) * 1996-04-29 1997-11-06 Novo Nordisk A/S Non-aqueous, liquid, enzyme-containing compositions
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
GB9613858D0 (en) 1996-07-02 1996-09-04 Cortecs Ltd Hydrophobic preparations
DE19724845A1 (de) * 1996-08-28 1998-03-05 Solvay Pharm Gmbh Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen
GB9624927D0 (en) * 1996-11-29 1997-01-15 Oxford Glycosciences Uk Ltd Gels and their use
US6140475A (en) * 1997-04-11 2000-10-31 Altus Biologics Inc. Controlled dissolution crosslinked protein crystals
AUPO693397A0 (en) 1997-05-22 1997-06-12 Betatene Limited Carotenoid formulation
NZ330940A (en) 1997-07-24 2000-02-28 F Production of consensus phytases from fungal origin using computer programmes
ES2137862B1 (es) 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
JP3611456B2 (ja) * 1997-09-30 2005-01-19 日研化学株式会社 テオフィリン徐放性錠剤
KR19990072826A (ko) 1998-02-26 1999-09-27 우재영 판크레아틴장용코팅과립의제조방법
FR2775597B1 (fr) 1998-03-04 2001-04-20 Gattefosse Ets Sa Pellet administrable par voie orale apte a ameliorer la biodisponibilite de la substance active, procede de fabrication
US20030021844A1 (en) * 1998-03-04 2003-01-30 Philippe Barthelemy Immediate-release oral pellet comprising polyglycolysed glycerides, and manufacturing process
BR9908692A (pt) * 1998-03-09 2001-12-04 Ista Pharmaceuticals Inc Uso de agentes de enrijecimento corneal emortocerotologia enzimática
UA69413C2 (uk) * 1998-05-22 2004-09-15 Брістол-Майерс Сквібб Компані Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції
DE29824797U1 (de) 1998-05-22 2002-08-22 Bristol-Myers Squibb Co., Princeton, N.J. Magensaftresistent überzogene Arzneimittel
US6268329B1 (en) * 1998-06-30 2001-07-31 Nouozymes A/S Enzyme containing granule
DE69913146T2 (de) 1998-06-30 2004-09-16 Novozymes A/S Neues, verbessertes, enzymhaltiges Granulat
DE19848849A1 (de) 1998-10-22 2000-04-27 Knoll Ag Verfahren zur Herstellung von festen, sphärischen Formen, enthaltend eine biologisch aktive Substanz
DE19856415C2 (de) 1998-12-08 2001-06-07 Thomas Fenner Verfahren zur Reinigung bzw. Isolierung viraler Nukleinsäuren
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US20030104048A1 (en) * 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
EP1162995B1 (de) * 1999-03-17 2003-06-04 Solvay Pharmaceuticals GmbH Enzyme zur behandlung von diabetes mellitus typ i
EP1186658B1 (de) 1999-05-27 2007-05-16 Amano Enzyme Inc. Enzymlauge und verfahren zu deren herstellung, enzymzubereitung, proteasezubereitungen und proteaseproduzierendes bakterium
JP4790957B2 (ja) 1999-10-01 2011-10-12 ノボザイムス アクティーゼルスカブ 酵素粒質物
JP4731777B2 (ja) 1999-10-12 2011-07-27 マルホ株式会社 経口医薬組成物
US6734188B1 (en) * 1999-11-01 2004-05-11 John Rhodes Composition for treatment of constipation and irritable bowel syndrome
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
EP1250057B1 (de) * 1999-12-30 2005-11-09 Kemin Industries, Inc. Verfahren zur verbesserung der aktivitaet von enzymen
WO2001058276A2 (en) 2000-02-08 2001-08-16 F Hoffmann-La Roche Ag Use of acid-stable proteases in animal feed
US20010046493A1 (en) * 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
KR20010100194A (ko) 2000-03-13 2001-11-14 박호군 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US20020146451A1 (en) * 2000-07-15 2002-10-10 Sharma Virender K. Method for the administration of acid-labile drugs
AU2001285723A1 (en) 2000-09-08 2002-03-22 Novozymes A/S Lubricated granules
DE60119947T2 (de) 2000-10-02 2007-01-04 Novozymes A/S Einen wirkstoff enthaltende, beschichtete teilchen
ATE295737T1 (de) * 2000-11-02 2005-06-15 Cilian Ag Verwendung von aus ciliaten gewonnenen enzymen als verdauungsfördernde arzneimittel
IT1319655B1 (it) * 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
AR032392A1 (es) * 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
US6692771B2 (en) * 2001-02-23 2004-02-17 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
US6676933B2 (en) * 2001-05-23 2004-01-13 Osmotica Corp. Pharmaceutical composition containing mosapride and pancreatin
DE60124895D1 (de) 2001-07-26 2007-01-11 Ethypharm Sa Umgehüllte Allylamine oder Benzylamine enthaltende Granulate, Verfahren zur Herstellung und in der Mundhöhle dispergierbare Tabletten enthaltend die umgehüllten Granulate
FR2827770B1 (fr) * 2001-07-27 2005-08-19 Gattefosse Ets Sa Composition pharmaceutique a usage oral comprenant un principe actif susceptible de subir un important effet de premier passage intestinal
US6749851B2 (en) * 2001-08-31 2004-06-15 Clearant, Inc. Methods for sterilizing preparations of digestive enzymes
JP2005515996A (ja) 2001-12-03 2005-06-02 ノバセア インコーポレイティッド 活性型ビタミンｄ化合物を含む薬学的組成物
WO2003055967A1 (en) 2001-12-21 2003-07-10 Novozymes A/S Salt coatings
JP2005520546A (ja) 2002-03-27 2005-07-14 ノボザイムス アクティーゼルスカブ フィラメントコーティングを有する粒体
US20040161423A1 (en) * 2002-07-18 2004-08-19 Sanjeev Kumar (Mendiratta) Polymer modified anti-angiogenic serpins
WO2004069872A1 (en) 2003-02-06 2004-08-19 Novozymes A/S Human heavy chain antibody expression in filamentous fungi
US20040213847A1 (en) * 2003-04-23 2004-10-28 Matharu Amol Singh Delayed release pharmaceutical compositions containing proton pump inhibitors
CA2528906C (en) * 2003-07-29 2013-07-16 Solvay Pharmaceuticals Gmbh Analytical method for pancreatin and comparable compositions
AR047440A1 (es) 2004-01-21 2006-01-18 Novozymes As Produccion de un anticuerpo monoclonal en un hongo heterocarion o una celula huesped fungal
ITMI20040891A1 (it) 2004-05-04 2004-08-04 Ibsa Inst Biochimique Sa Nuovo metodo per la partizione ed inattivazione di contaminanti virali e prionici
AU2005295754B2 (en) 2004-10-14 2010-09-09 Eli Lilly And Co. Compositions containing lipase; protease and amylase for treating pancreatic insufficiency
WO2006136159A2 (en) 2005-06-24 2006-12-28 Novozymes A/S Lipases for pharmaceutical use
JP5140586B2 (ja) 2005-07-29 2013-02-06 アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング 滅菌パンクレアチン粉末の製法
US9198871B2 (en) * 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
CA2619477C (en) 2005-08-15 2015-05-26 Solvay Pharmaceuticals Gmbh Pancreatin micropellet cores suitable for enteric coating
US11266607B2 (en) * 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US10072256B2 (en) * 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
KR20090101930A (ko) 2006-12-21 2009-09-29 노보자임스 에이/에스 약학적 사용을 위한 리파아제 변형체
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
US10087493B2 (en) * 2008-03-07 2018-10-02 Aptalis Pharma Canada Ulc Method for detecting infectious parvovirus in pharmaceutical preparations

Also Published As

Publication number Publication date
US20140302000A1 (en) 2014-10-09
HK1101342A1 (en) 2007-10-18
JP5032300B2 (ja) 2012-09-26
AU2005227090A1 (en) 2005-10-06
DE602005009677D1 (de) 2008-10-23
JP2007530503A (ja) 2007-11-01
CA2560613A1 (en) 2005-10-06
US8802087B2 (en) 2014-08-12
PT1729797E (pt) 2008-12-17
PL1729797T3 (pl) 2009-02-27
CN1933850B (zh) 2011-01-12
BRPI0509148B1 (pt) 2016-07-12
ES2314646T3 (es) 2009-03-16
BRPI0509148B8 (pt) 2021-05-25
EP1729797B1 (de) 2008-09-10
US20050250817A1 (en) 2005-11-10
CN1933850A (zh) 2007-03-21
RU2381813C2 (ru) 2010-02-20
RU2006137325A (ru) 2008-04-27
CA2560613C (en) 2015-11-24
WO2005092370A1 (en) 2005-10-06
US20190275122A1 (en) 2019-09-12
AU2005227090B2 (en) 2010-12-09
EP1729797A1 (de) 2006-12-13
BRPI0509148A (pt) 2007-09-11

Similar Documents

Publication Publication Date Title
ATE407693T1 (de) Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin,mit tensiden
HUP0500560A2 (hu) Mikróbás enzimek új keverékei
NO20085243L (no) Farmasoytisk sammensetning til behandling av virusinfeksjoner og/eller tumorsykdommer gjennom inhibering av proteinfolding og Proteinnedbryting
ES2572160T3 (es) Una nueva preparación farmacéutica para preeclampsia
WO2008021987A3 (en) Proteolytic enzyme formulations
MA30515B1 (fr) Formulations lyophilisees d'anticorps anti-egfr
BRPI0510817A (pt) protease, uso de uma protease, composição farmacêutica, e, método para o tratamento de uma doença
DE60036961D1 (de) Gamma-hydroxy-2-(fluoralkylaminocarbonyl)-1-piperazinpentanamide als hiv-proteasehemmer
WO2002051424A8 (en) Drugs against articular failure
WO2007081755A3 (en) Indole-benzimidazole and indazole inhibitors of tyrosine phosphatases
DOP2023000074A (es) Compuestos fosfolípidos y usos de estos
CR20230100A (es) Compuestos fosfolípidos y usos de los mismos
BR9910151A (pt) Composições detergentes de lavanderia e/ou para o cuidado de tecidos compreendendo uma enzima modificada
DOP2025000244A (es) Compuestos y métodos para el tratamiento de infecciones virales
EA201070826A1 (ru) Антитела против pcrv
WO2005110428A3 (en) Resistance-repellent retroviral protease inhibitors
BR0306928A (pt) Composições farmacêuticas estáveis compreendendo inibidores de enzimas conversoras de angiotensina (ace)
EP1453525A4 (de) Selektives targeting von apoptotischen zellen
WO2006100679A3 (en) Recombinant antibodies against human type ii transglutaminase and uses thereof
ATE295737T1 (de) Verwendung von aus ciliaten gewonnenen enzymen als verdauungsfördernde arzneimittel
DE602007001519D1 (de) Zusammensetzung mit mehreren botulinumtoxinen
WO2008021048A3 (en) Adp-ribosyltransferase based methods and compositions
WO2005062952A3 (en) Compositions and methods for modulating sirtuin activity
ATE395064T1 (de) Kombinationspräparate von 3-n- formylhydroxylaminopropylphosphonsäurederivaten oder 3-n- acetylhydroxylaminopropylphosphonsäurederivaten mit speziellen pharmazeutischen wirkstoffen
WO2006017124A3 (en) Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1729797

Country of ref document: EP