US20080058282A1 - Use of lactulose in the treatment of autism - Google Patents

Use of lactulose in the treatment of autism Download PDF

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Publication number
US20080058282A1
US20080058282A1 US11/468,379 US46837906A US2008058282A1 US 20080058282 A1 US20080058282 A1 US 20080058282A1 US 46837906 A US46837906 A US 46837906A US 2008058282 A1 US2008058282 A1 US 2008058282A1
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Prior art keywords
lactulose
effective amount
individual
method
composition
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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US11/468,379
Inventor
Joan M. Fallon
Richard Feltenstein
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FALLON JOAN M
Curemark LLC
Original Assignee
Fallon Joan M
Richard Feltenstein
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Priority to US71255105P priority Critical
Application filed by Fallon Joan M, Richard Feltenstein filed Critical Fallon Joan M
Priority to US11/468,379 priority patent/US20080058282A1/en
Publication of US20080058282A1 publication Critical patent/US20080058282A1/en
Assigned to FALLON, JOAN M., MS reassignment FALLON, JOAN M., MS ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FELTENSTEIN, RICHARD, MR.
Assigned to CUREMARK LLC reassignment CUREMARK LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FALLON, JOAN M.
Application status is Abandoned legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016Disaccharides, e.g. lactose, lactulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid

Abstract

A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.

Description

    RELATED APPLICATIONS
  • This application claims the benefit of U.S. Provisional Application No. 60/712,551, filed Aug. 30, 2005. This application is herein incorporated in its entirety by reference.
  • FIELD OF THE INVENTION
  • The invention relates to a treatment for autism, and more particularly, to the use of lactulose in the treatment of autism.
  • BACKGROUND OF THE INVENTION
  • Autism is the most prevalent of a subset of disorders organized under the umbrella of pervasive developmental disorder (PDD). Autism is a serious developmental disorder characterized by profound deficits in language, communication, and socialization, resistance to learning, and displays of stereotypical behavior including perseveration. Known now as a spectrum disorder (ASD), it includes a myriad of behavioral, emotional, and physiological symptoms. Autism is a life-long developmental disorder affecting as many as 1 in 500 children. Recent studies have indicated that the prevalence is closer to 1 in 166 live births. The causes of this profound disorder are largely unknown. Recent research has uncovered pathology in the gastrointestinal tract of autistic children. The pathology is reported to extend from the esophagus to the colon.
  • Lactulose is presently used in the treatment of constipation and hepatic encephalopathy. The efficacy of lactulose in these conditions is based on its fermentation in the colon by certain bacteria and the increase of the biomass of these bacteria in the colon. The products of fermentation are mainly organic acids, such as lactic acid and small-chain fatty acids, which, by exerting a local osmotic effect in the colon, result in increased fecal bulk and stimulation of peristalsis. The higher doses used for hepatic encephalopathy lower the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and improves mental function.
  • Increased or high levels of ammonia in the blood stream can produce toxicity to the cells of the body especially to the cells of the nervous system. This neurotoxicity can alter brain function and cause other neurological diseases, including autism. Thus, decreasing the levels of ammonia in the blood would decrease the levels of ammonia in the brain thereby reducing the neurotoxic effects.
  • Certain drugs such as Augmentin® (amoxicillin+clavulanate potassium) have been known to leave an ammonia residue in the gastrointestinal tract. The increased levels of ear infections in children with autism and the use of Augmentin® to treat these and other infections makes the child vulnerable to the potential buildup of ammonia in the digestive system as well as the blood, thus leading to a potential neurotoxic state. By giving lactulose immediately following the administration of Augmentin® or other ammonia producing substances, the potential for a neurotoxic disease is reduced.
  • It can be appreciated that lactulose has been used for years as a treatment for constipation and hepatic encephalopathy. However, lactulose has not previously been used as a treatment for autism or autism prevention. Presently, there exists no other pharmaceutical or biological treatment for autism. Since there is no pharmaceutical or biological treatment for autism, other than psychotropic medications for symptoms, only behavioral and educational solutions have been offered. Behavioral treatments, such as applied behavioral analysis and TEACCH (Treatment and Education of Autistic and related Communication Handicapped Children) and others, have some value in the treatment of these children but do not address the physiological, specifically gastrointestinal, problems encountered by them.
  • What is needed, therefore, is a treatment for autism that works by preventing the build up of ammonia in the gastrointestinal tract, the bloodstream, and the nervous system.
  • SUMMARY OF THE INVENTION
  • It is a goal of the present invention provide a treatment for autism that addresses the physiological symptoms of the disorder.
  • It is another goal of the present invention to provide a treatment for autism that works by preventing the build up of ammonia in the gastrointestinal tract, the bloodstream, and the nervous system.
  • It is a further goal of the present invention to provide a treatment for autism that reverses the effects of ammonia poisoning on the gastrointestinal tract, the bloodstream, and the nervous system caused by certain antibiotics.
  • In one embodiment, lactulose is used to bind ammonia in the gastrointestinal tract, the bloodstream, and the nervous system.
  • The features and advantages described herein are not all-inclusive and, in particular, many additional features and advantages will be apparent to one of ordinary skill in the art in view of the drawings, specification, and claims. Moreover, it should be noted that the language used in the specification has been principally selected for readability and instructional purposes, and not to limit the scope of the inventive subject matter.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a block diagram illustrating the mechanism of the function of lactulose in the colon.
  • DETAILED DESCRIPTION
  • Lactulose is a semisynthetic disaccharide comprised of the sugars D-galactose and D-fructose. It is not found naturally. The sugars are joined by a beta glycosidic linkage making it resistant to hydrolysis by human digestive enzymes. There is no disaccharidase in the microvillus membrane of small intestine enterocytes that can hydrolyze lactulose; nor is the disaccharide absorbed from the small intestine. Lactulose is, however, fermented by a limited number of colonic bacteria. This can lead to changes in the colonic ecosystem in favor of some bacteria, such as lactobacilli and bifidobacteria, which may confer some health benefits.
  • Lactulose is a solid substance that is very soluble in water and has a sweet taste. It is sweeter than lactose but not as sweet as fructose. Lactulose is also known as 4-O-beta-D-galactopyranosyl-D-fructofuranose. Its molecular formula is C12H22O11, and its molecular weight is 342.30 daltons. The structural formula is:
  • Figure US20080058282A1-20080306-C00001
  • Lactulose has an inhibiting action on ammonia production in the ileum and reduces the ammonia level in portal circulation. Referring to FIG. 1, lactulose molecules pass through the stomach and ileum unsplit. Once in the colon, the lactulose is fermented by certain bacteria, which supplies carbohydrates and energy. This results in an increase of the biomass of these bacteria in the colon. The products of fermentation are mainly organic acids, such as lactic acid and small-chain fatty acids, which, by exerting a local osmotic effect in the colon, result in increased fecal bulk and stimulation of peristalsis. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and improves mental function.
  • It has been postulated that there is a relationship between the use of the antibiotic Augmentin® and autism. Many autistic children suffer from chronic otitis media (ear infections) prior to age three. Otitis media is generally by two strains of bacteria, Streptococcus pneumoniae and Hemophilus influenzae. Augmentin® (amoxicillin-clavulanate) is a frequently prescribed antibiotic for this condition because it is effective against both of these strains. However, the process of manufacturing Augmentin® involves the addition of urea or another available ammonia source to a fermentation broth. This additional ammonia represses the number of enzymes involved in the metabolism of nitrogen, including urease, which catalyzes the conversion of urea to ammonia and carbon dioxide. Thus, there is the possibility of urea and/or nitrogen poisoning.
  • Urea and/or nitrogen poisoning has a two-fold effect in humans: 1) a neurotoxic effect on brain tissue and 2) a corrosive effect on the digestive tract, specifically damage to the secretory cells of the small intestine, due to the highly alkaline nature of NH3. Signs of urea poisoning include colic, bloating, diarrhea, muscle tremors, difficulty with coordination, weakness, and poor appetite.
  • In a study conducted by the inventor, 206 children with autism not related to a known genetic condition, birth trauma, or known neurological disease were examined and a detailed case history was obtained. The 206 children tested had a mean number of 9.96 instances of otitis media with a standard error of the mean of ±1.83. This represented a sum total for the 206 children under age three of 2052 bouts of otitis media. These children received a mean number of 12.04 courses of antibiotics with a standard error of the mean of ±0.13. The total number of courses given to all of the children in the study was 2,480. Of those courses, 893 were Augmentin®, with 362 of those courses of Augmentin® being administered to children under age one.
  • The increased levels of ear infections in children with autism combined with the use of Augmentin® to treat these infections has the potential to make these children vulnerable to the buildup of ammonia in the gastrointestinal tract, the bloodstream, and the nervous system, leading to a neurotoxic state. By administering lactulose subsequent to a course of treatment with Augmentin® or other antibiotics that leave an ammonia residue in the gastrointestinal tract, the potential for a neurological disease, such as autism, is reduced.
  • In one embodiment of the present invention, the treatment has a formulation of 0.4 g/kg lactulose and 0.1 g/kg mannitol. In another embodiment, the treatment has a formulation of 0.3 g/kg lactulose. In either embodiment, the treatment is administered two to five times per day. The lactulose may be administered in the form of a powder, liquid solution, or syrup.
  • The foregoing description of the embodiments of the invention has been presented for the purposes of illustration and description. It is not intended to be exhaustive or to limit the invention to the precise form disclosed. Many modifications and variations are possible in light of this disclosure. It is intended that the scope of the invention be limited not by this detailed description, but rather by the claims appended hereto.

Claims (20)

1. A method for treating an individual exhibiting one or more symptoms of autistic disorder, the method comprising administering an effective amount of lactulose to the individual.
2. The method of claim 1, wherein one of the symptoms is selected from a group consisting of a gastrointestinal disorder, a neurological disorder, and a combination thereof.
3. The method of claim 1, wherein the effective amount of lactulose comprises about 0.4 g/kg lactulose and 0.1 g/kg mannitol per dose.
4. The method of claim 1, wherein the effective amount of lactulose comprises about 0.3 g/kg lactulose per dose.
5. The method of claim 1, wherein the effective amount of lactulose is administered approximately two to five times per day.
6. The method of claim 1, wherein the effective amount of lactulose is administered in a form selected from the group consisting of a powder, liquid solution, syrup, and a combination thereof.
7. The method of claim 1, wherein the effective amount of lactulose includes an amount of lactulose sufficient to decrease ammonia levels in the blood of the individual.
8. The method of claim 1, wherein the effective amount of lactulose includes an amount of lactulose sufficient to decrease ammonia levels in the gastrointestinal tract of the individual.
9. The method of claim 1, wherein the effective amount of lactulose includes an amount of lactulose sufficient to decrease ammonia levels in the nervous system of the individual.
10. The method of claim 1, wherein the effective amount of lactulose includes an amount of lactulose sufficient to reverse ammonia poisoning caused by the administration of antibiotics that leave a residue in the gastrointestinal tract of the individual.
11. A composition for treating autism and the symptoms thereof in an individual comprising an effective amount of lactulose.
12. The composition of claim 11, wherein one of the symptoms is selected from a group consisting of a gastrointestinal disorder, a neurological disorder, and a combination thereof.
13. The composition of claim 11, wherein the effective amount of lactulose comprises about 0.4 g/kg lactulose and 0.1 g/kg mannitol per dose.
14. The composition of claim 11, wherein the effective amount of lactulose comprises about 0.3 g/kg lactulose per dose.
15. The composition of claim 11, wherein the effective amount of lactulose is administered approximately two to five times per day.
16. The composition of claim 11, wherein the effective amount of lactulose is manufactured in a form selected from the group consisting of a powder, liquid solution, syrup, and a combination thereof.
17. The composition of claim 11, wherein the effective amount of lactulose includes an amount of lactulose sufficient to decrease ammonia levels in the blood of the individual.
18. The composition of claim 11, wherein the effective amount of lactulose includes an amount of lactulose sufficient to decrease ammonia levels in the gastrointestinal tract of the individual.
19. The composition of claim 11, wherein the effective amount of lactulose includes an amount of lactulose sufficient to decrease ammonia levels in the nervous system of the individual.
20. The composition of claim 11, wherein the effective amount of lactulose includes an amount of lactulose sufficient to reverse ammonia poisoning caused by the administration of antibiotics that leave a residue in the gastrointestinal tract of the individual.
US11/468,379 2005-08-30 2006-08-30 Use of lactulose in the treatment of autism Abandoned US20080058282A1 (en)

Priority Applications (2)

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US71255105P true 2005-08-30 2005-08-30
US11/468,379 US20080058282A1 (en) 2005-08-30 2006-08-30 Use of lactulose in the treatment of autism

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US11/468,379 US20080058282A1 (en) 2005-08-30 2006-08-30 Use of lactulose in the treatment of autism
US12/049,613 US20080161265A1 (en) 2005-08-30 2008-03-17 Use of lactulose in the treatment of autism
US13/204,881 US8673877B2 (en) 2005-08-30 2011-08-08 Use of lactulose in the treatment of autism
US14/087,930 US9345721B2 (en) 2005-08-30 2013-11-22 Use of lactulose in the treatment of autism
US15/089,842 US20160213697A1 (en) 2005-08-30 2016-04-04 Use of lactulose in the treatment of autism

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US12/049,613 Abandoned US20080161265A1 (en) 2005-08-30 2008-03-17 Use of lactulose in the treatment of autism
US13/204,881 Active US8673877B2 (en) 2005-08-30 2011-08-08 Use of lactulose in the treatment of autism
US14/087,930 Active US9345721B2 (en) 2005-08-30 2013-11-22 Use of lactulose in the treatment of autism
US15/089,842 Pending US20160213697A1 (en) 2005-08-30 2016-04-04 Use of lactulose in the treatment of autism

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US13/204,881 Active US8673877B2 (en) 2005-08-30 2011-08-08 Use of lactulose in the treatment of autism
US14/087,930 Active US9345721B2 (en) 2005-08-30 2013-11-22 Use of lactulose in the treatment of autism
US15/089,842 Pending US20160213697A1 (en) 2005-08-30 2016-04-04 Use of lactulose in the treatment of autism

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Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020081628A1 (en) * 2000-11-16 2002-06-27 Fallon Joan M. Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20040071683A1 (en) * 1999-12-17 2004-04-15 Fallon Joan M. Methods for treating pervasive development disorders
US20070053895A1 (en) * 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
US20070116695A1 (en) * 2005-09-21 2007-05-24 Fallon Joan M Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders
US20080166334A1 (en) * 2004-09-28 2008-07-10 Fallon Joan M Combination enzyme for cystic fibrosis
US20090232789A1 (en) * 2008-03-13 2009-09-17 Fallon Joan M Novel pharmaceutical preparation for preeclampsia, eclampsia, and toxemia, and their related symptoms and related disorders of pregnancy
US20090263372A1 (en) * 2008-04-18 2009-10-22 Fallon Joan M Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US20090324572A1 (en) * 2008-06-26 2009-12-31 Fallon Joan M Methods and compositions for the treatment of symptoms of williams syndrome
US20100169409A1 (en) * 2008-08-04 2010-07-01 Fallon Joan M Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of parkinsons disease, movement and neurological disorders, and chronic pain
US20100260857A1 (en) * 2009-04-13 2010-10-14 Joan Fallon Enzyme delivery systems and methods of preparation and use
US20110182818A1 (en) * 2008-07-01 2011-07-28 Fallon Joan M Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US8673877B2 (en) 2005-08-30 2014-03-18 Curemark, Llc Use of lactulose in the treatment of autism
US8980252B2 (en) 2011-04-21 2015-03-17 Curemark Llc Methods of treatment of schizophrenia
US9061033B2 (en) 2008-10-03 2015-06-23 Curemark Llc Methods and compositions for the treatment of symptoms of prion diseases
US9084784B2 (en) 2009-01-06 2015-07-21 Curelon Llc Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces
US9107419B2 (en) 2009-01-06 2015-08-18 Curelon Llc Compositions and methods for treatment or prevention of Staphylococcus aureus infections and for the eradication or reduction of Staphylococcus aureus on surfaces
US9511125B2 (en) 2009-10-21 2016-12-06 Curemark Llc Methods and compositions for the treatment of influenza

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011056087B4 (en) 2011-12-06 2018-08-30 Solarworld Industries Gmbh Solar cell wafers and methods for metallizing a solar cell
WO2013139861A1 (en) 2012-03-20 2013-09-26 Luc Montagnier Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743447B2 (en) * 2000-03-29 2004-06-01 Roquette Freres Pulverulent mannitol and process for preparing it

Family Cites Families (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE491927A (en) 1948-10-30
US3002883A (en) * 1959-07-29 1961-10-03 Dow Chemical Co Disinfectant compositions
GB928654A (en) * 1960-10-25 1963-06-12 Philips Nv Improvements in or relating to the production of pancreatin
US3322626A (en) 1963-06-13 1967-05-30 Pannett Products Inc Medicinal composition for treating acne and method of using same
US3357894A (en) * 1963-10-18 1967-12-12 Ct Nat De La Recherche Proteolytic enzymes of pig pancreas
DE1517787A1 (en) * 1965-12-06 1970-01-29 Takeda Chemical Industries Ltd Enzympraeparat and process for its preparation
DE1617417A1 (en) * 1966-12-08 1971-03-25 Ciba Geigy pharmaceutical preparation
US3860708A (en) * 1973-11-15 1975-01-14 Philips Corp Method of delivering the intestines of human beings from bariumsulphate after barium meal examination
US3940478A (en) * 1974-04-29 1976-02-24 Sutures, Inc. Proteolytic enzymes as adjuncts to antibiotic prophylaxis of contaminated wounds
GB1509866A (en) * 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
US4086257A (en) 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
DE2923279C2 (en) 1979-06-08 1987-07-09 Kali-Chemie Pharma Gmbh, 3000 Hannover, De
US5250418A (en) * 1981-10-06 1993-10-05 Boehringer Mannheim Gmbh Process and reagent for determining the activity of chymotrypsin and trypsin in feces
EP0115023B1 (en) 1982-12-30 1988-07-27 Nordmark Arzneimittel GmbH Process for obtaining pancreatin
EP0133438A1 (en) 1983-01-21 1985-02-27 Advanced Drug Technology Corporation Enzyme ointment
US4447412A (en) 1983-02-01 1984-05-08 Bilton Gerald L Enzyme-containing digestive aid compostions
US4456544A (en) 1983-08-05 1984-06-26 Vsesojuzny Nauchno-Issledovatelsky Biotecknichesky Institut Enzyme-containing detergent composition for presterilization treatment of medical instruments and equipment
US6309669B1 (en) * 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
DE3650184D1 (en) * 1985-12-03 1995-02-09 T Cell Sciences Inc Free cells t cells antigen receptor and clinical use.
JPH0475888B2 (en) 1986-03-31 1992-12-02 Snow Brand Milk Prod Co Ltd
US4826679A (en) 1986-05-23 1989-05-02 Universite De Montreal Composition and methods for alleviating cystic fibrosis
CN1039706A (en) 1988-08-04 1990-02-21 黄族和 Method of making artificial fa vegetable
GB8821049D0 (en) 1988-09-08 1988-10-05 Health Lab Service Board Method & composition for treatment & prevention of viral infections
GB8923788D0 (en) 1989-10-23 1989-12-13 Unilever Plc Enzymatic detergent compositions and their use
PH30058A (en) 1989-11-24 1996-11-08 Biochemie Gmbh Pancreation preparations
CA2037178A1 (en) 1990-02-28 1991-08-29 Albert Walter Brzeczko Deprenyl/l-dopa/carbidopa pharmaceutical composition
US5618710A (en) * 1990-08-03 1997-04-08 Vertex Pharmaceuticals, Inc. Crosslinked enzyme crystals
US5607863A (en) * 1991-05-29 1997-03-04 Smithkline Diagnostics, Inc. Barrier-controlled assay device
US5190775A (en) * 1991-05-29 1993-03-02 Balchem Corporation Encapsulated bioactive substances
JPH04364119A (en) 1991-06-11 1992-12-16 Tsumura & Co Bathing agent composition
IL99628A (en) 1991-10-02 2004-07-25 Yissum Res Dev Co Processes for the preparation of cyclic peptides, and pharmaceutical compositions containing them
WO1993010755A1 (en) 1991-11-25 1993-06-10 Richardson-Vicks, Inc. Compositions for regulating skin wrinkles and/or skin atrophy
US7242988B1 (en) 1991-12-23 2007-07-10 Linda Irene Hoffberg Adaptive pattern recognition based controller apparatus and method and human-factored interface therefore
GB9207280D0 (en) 1992-04-02 1992-05-13 Unilever Plc Skin care method and composition
WO1993025219A1 (en) * 1992-06-12 1993-12-23 Cephalon, Inc. Prevention and treatment of peripheral neuropathy
US5260074A (en) * 1992-06-22 1993-11-09 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5460812A (en) 1992-06-22 1995-10-24 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
DE4227385A1 (en) 1992-08-19 1994-02-24 Kali Chemie Pharma Gmbh pancreatin
GB9218363D0 (en) * 1992-08-28 1992-10-14 Black & Decker Inc Pivoting power tool with table
DE4305460C2 (en) 1993-02-23 1997-09-04 Albert Dr Scheller Pharmaceutical or cosmetic containing enzymes preparation, processes for their preparation and their use
TW310277B (en) 1993-05-21 1997-07-11 Pou Lin Fu Gin Pharm Co The method of preparing enteric-coated pancreatin granules and its dosage forms
DE4332985A1 (en) 1993-09-28 1995-03-30 Konrad Peter Maria Dr Sommer Pharmaceutical composition for the treatment of exocrine pancreas dysfunction
GB9403250D0 (en) 1994-02-21 1994-04-13 Univ Mcgill Therapeutic use of myelin-associated glycoprotein (mag)
GB9405304D0 (en) 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
US20080311554A1 (en) 1994-05-06 2008-12-18 Slotman Gus J Methods for monitoring patients with severe sepsis and septic shock and for selecting treatments for these patients
US5527678A (en) * 1994-10-21 1996-06-18 Vanderbilt University CagB and CagC genes of helicobacter pylori and related compositions
US5476661A (en) 1994-10-21 1995-12-19 Elizabeth Arden Co., Division Of Conopco, Inc. Compositions for topical application to skin, hair and nails
AUPN033894A0 (en) * 1994-12-29 1995-01-27 Rowe, J.B. Prevention of adverse behaviour in humans and animals
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6558708B1 (en) 1995-05-17 2003-05-06 Cedars-Sinai Medical Center Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
CA2220451A1 (en) 1995-05-17 1996-11-21 Cedars-Sinai Medical Center Methods and compositions for improving digestion and absorption in the small intestine
US5686311A (en) * 1995-06-23 1997-11-11 The Children's Mercy Hospital Diagnosis of autism and treatment therefor
AU6682796A (en) * 1995-07-21 1997-02-18 New York University Type ii phospholipase a2 and its use in killing gram-positive bacteria
US5952178A (en) * 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
BR9707836A (en) 1996-03-06 1999-07-27 Novo Nordisk Processes for inhibiting microorganisms present in clothes washing and microbial growth on a hard surface and to kill microbial cells present on the skin of human or animal mucous membranes in the teeth injuries bruises or in the eye or inhibiting their growth
US5958875A (en) * 1996-03-29 1999-09-28 The Regents Of The University Of California Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
GB2318511A (en) 1996-10-23 1998-04-29 Eurand Int Process for the preparation of a pharmaceutical composition for rapid suspension in water
US5860932A (en) 1996-10-24 1999-01-19 Colin Corporation Blood pressure monitor
CA2190418A1 (en) 1996-11-15 1998-05-15 Zhi-Cheng Xiao Neuron and neural tumor growth regulatory system, antibodies thereto and uses thereof
CA2198317C (en) 1997-02-24 2003-01-07 Mouhsine El Abboudi Method for preparing pancreatin which contains low amounts of residual organic solvent and product thereof
NZ337954A (en) 1997-03-13 2001-09-28 First Opinion Corp Computerized disease management method adjusts a disease therapy for a patient based on obtained health data
US5858758A (en) 1997-05-07 1999-01-12 Incyte Pharmaceuticals, Inc. Human serine protease precursor
US6197746B1 (en) * 1998-05-19 2001-03-06 Repligen Corporation Method of using secretin for treating autism
US6020310A (en) 1997-05-19 2000-02-01 Repligen Corporation Method for assisting in differential diagnosis and treatment of autistic syndromes
US6482839B1 (en) * 1997-06-02 2002-11-19 Cellegy Pharmaceuticals, Inc. Pyridine-thiols for treatment of a follicular dermatosis
GB2347742B (en) 1997-06-05 2001-11-07 Royal Free Hosp School Med Pharmaceutical composition for RBD
GB2325856A (en) * 1997-06-05 1998-12-09 Royal Free Hosp School Med Pharmaceutical composition for treatment of MMR virus mediated disease comprising a transfer factor obtained from the dialysis of virus-specific lymphocytes
KR19990072826A (en) 1998-02-26 1999-09-27 우재영 A process for producing enteric-coated pancreatin granules
AT429813T (en) 1998-10-09 2009-05-15 Gen Mills Inc Encapsulation of sensitive liquid components into a matrix for recovery of discrete shelf-stable particles
US6020314A (en) * 1998-08-11 2000-02-01 Milkhaus Laboratory, Inc. Methods for treatment of neurological disorders
US6149585A (en) 1998-10-28 2000-11-21 Sage Health Management Solutions, Inc. Diagnostic enhancement method and apparatus
US6168569B1 (en) 1998-12-22 2001-01-02 Mcewen James Allen Apparatus and method for relating pain and activity of a patient
US6753306B2 (en) 1998-12-23 2004-06-22 Joseph J. Simpson Germicidal and disinfectant composition
CZ20013345A3 (en) 1999-03-17 2002-01-16 Solvay Pharmaceuticals Gmbh Medicament for treating diabetes mellitus
US7945451B2 (en) 1999-04-16 2011-05-17 Cardiocom, Llc Remote monitoring system for ambulatory patients
US6210950B1 (en) * 1999-05-25 2001-04-03 University Of Medicine And Dentistry Of New Jersey Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors
US6153236A (en) * 1999-06-03 2000-11-28 Balchem Corporation Low melt encapsulation with high laurate canola oil
JP2003502071A (en) 1999-06-18 2003-01-21 ブジャーナソン・ヨーン・ブラーギ Use of the fish serine proteinase and their chemical and cosmetics
US7395216B2 (en) 1999-06-23 2008-07-01 Visicu, Inc. Using predictive models to continuously update a treatment plan for a patient in a health care location
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US6562629B1 (en) 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
US6187309B1 (en) * 1999-09-14 2001-02-13 Milkaus Laboratory, Inc. Method for treatment of symptoms of central nervous system disorders
US20010024660A1 (en) 1999-09-29 2001-09-27 Ismat Ullah Enteric coated pharmaceutical composition and method of manufacturing
US6447772B1 (en) 1999-10-01 2002-09-10 Klaire Laboratories, Inc. Compositions and methods relating to reduction of symptoms of autism
JP2003511698A (en) * 1999-10-12 2003-03-25 コンネクス・ゲゼルシャフト・ツーア・オプティミエルング・フォン・フォルシュング・ウント・エントヴィックルング・エムベーハー Improved detection method of acid-resistant microorganisms in the stool
US6727073B1 (en) * 1999-11-19 2004-04-27 Binax, Inc. Method for detecting enteric disease
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20020103675A1 (en) 1999-11-29 2002-08-01 John Vanelli Apparatus and method for providing consolidated medical information
US6632429B1 (en) 1999-12-17 2003-10-14 Joan M. Fallon Methods for treating pervasive development disorders
US6534063B1 (en) * 1999-12-17 2003-03-18 Joan M. Fallon Methods for treating pervasive development disorders
US6251478B1 (en) 1999-12-22 2001-06-26 Balchem Corporation Sensitive substance encapsulation
US6564104B2 (en) 1999-12-24 2003-05-13 Medtronic, Inc. Dynamic bandwidth monitor and adjuster for remote communications with a medical device
US6980958B1 (en) 2000-01-11 2005-12-27 Zycare, Inc. Apparatus and methods for monitoring and modifying anticoagulation therapy of remotely located patients
US6468210B2 (en) 2000-02-14 2002-10-22 First Opinion Corporation Automated diagnostic system and method including synergies
US6261613B1 (en) * 2000-02-15 2001-07-17 General Mills, Inc. Refrigerated and shelf-stable bakery dough products
US6399101B1 (en) * 2000-03-30 2002-06-04 Mova Pharmaceutical Corp. Stable thyroid hormone preparations and method of making same
AUPQ679100A0 (en) 2000-04-07 2000-05-11 Novapharm Research (Australia) Pty Ltd Process and composition for cleaning medical instruments
US6399114B2 (en) 2000-05-26 2002-06-04 C & D Foreman, Inc. Nutritional system for nervous system disorders
US6783757B2 (en) 2000-06-01 2004-08-31 Kirkman Group, Inc. Composition and method for increasing exorphin catabolism to treat autism
US20040062757A1 (en) * 2001-06-05 2004-04-01 Finegold Sydney M. Method of testing gastrointestinal diseases associated with species of genus clostridium
AUPQ899700A0 (en) * 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
WO2002014537A2 (en) 2000-08-14 2002-02-21 Fallon Joan M Methods for diagnosing and treating dysautonomia and other dysautonomic conditions
US20070053895A1 (en) 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
IT1319655B1 (en) * 2000-11-15 2003-10-23 Eurand Int Microspheres of pancreatic enzymes with high stability 'and relativometodo preparation.
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20020119914A1 (en) 2000-12-26 2002-08-29 Deguang Zhu New uses of insulin and pancreatin
GB2370839A (en) * 2001-01-06 2002-07-10 Benedikt Timmerman Immunogenic complex useful for disease control
CN1150032C (en) 2001-01-15 2004-05-19 孙芳梅 Concentrated granular medicine for treating baby diarrhea and its preparing process
AR032392A1 (en) 2001-01-19 2003-11-05 Solvay Pharm Gmbh Enzyme mixture, a pharmaceutical preparation and utilization of that preparation.
US7588757B2 (en) 2001-03-14 2009-09-15 Genzyme Corporation Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
US7107996B2 (en) * 2001-04-10 2006-09-19 Ganz Robert A Apparatus and method for treating atherosclerotic vascular disease through light sterilization
US7034134B2 (en) * 2001-04-26 2006-04-25 Bristol-Myers Squibb Company Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29
US7101573B2 (en) * 2001-09-28 2006-09-05 Mcneil-Pcc, Inc. Simethicone solid oral dosage form
US7232670B2 (en) 2001-09-28 2007-06-19 St. Jude Children's Research Hospital Targeting proteins to cells expressing mannose receptors via expression in insect cells
US7630911B2 (en) 2001-10-24 2009-12-08 Qtc Management, Inc. Method of automated processing of medical data for insurance and disability determinations
AU2002364750A1 (en) 2001-12-14 2003-06-30 Solvay Pharmaceuticals Gmbh Use of digestive enzyme mixtures for treating pathological bacterial overgrowth of the small intestine of mammals and humans
US6797291B2 (en) * 2002-01-09 2004-09-28 Balchem Corporation Stable hygroscopic compositions and methods for stabilizing hygroscopic ingredients
US7226771B2 (en) * 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
EP2266525B1 (en) 2002-05-03 2012-07-11 Martek Biosciences Corporation High quality lipids and methods for producing by enzymatic liberation from biomass
US20040131567A1 (en) * 2002-07-08 2004-07-08 Wilkins Joe S. Antibacterial topical formulations
US20040005304A1 (en) 2002-07-08 2004-01-08 Mak Wood, Inc. Novel compositions and methods for treating neurological disorders and associated gastrointestinal conditions
JP2006516889A (en) * 2002-10-10 2006-07-13 ダイヴァーサ コーポレイション Protease, nucleic acids and methods of making and using thereof encoding it
US20050079594A1 (en) 2002-10-31 2005-04-14 Karine Marion Method of removing a biofilm
US6835397B2 (en) * 2002-12-23 2004-12-28 Balchem Corporation Controlled release encapsulated bioactive substances
US8946151B2 (en) 2003-02-24 2015-02-03 Northern Bristol N.H.S. Trust Frenchay Hospital Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
US7780595B2 (en) 2003-05-15 2010-08-24 Clinical Decision Support, Llc Panel diagnostic method and system
US7289761B2 (en) 2003-06-23 2007-10-30 Cardiac Pacemakers, Inc. Systems, devices, and methods for selectively preventing data transfer from a medical device
US7354569B2 (en) 2003-07-11 2008-04-08 Colgate-Palmolive Company Chewable antiplaque confectionery dental composition
MXPA06001173A (en) 2003-07-29 2006-04-11 Solvay Pharm Gmbh Analytical method for pancreatin and comparable compositions.
WO2005027953A2 (en) 2003-09-23 2005-03-31 Dsm Ip Assets B.V. Use of proline specific endoproteases to hydrolyse peptides and proteins
US7381698B2 (en) 2003-12-12 2008-06-03 Chirhoclin, Inc. Methods for treatment of acute pancreatitis
US20050187130A1 (en) * 2004-02-23 2005-08-25 Brooker Alan T. Granular laundry detergent composition comprising an anionic detersive surfactant, and low levels of, or no, zeolite builders and phosphate builders
US20050232894A1 (en) 2004-04-20 2005-10-20 Weiner Gregory M Antimicrobial skin treatment composition and methods for producing and using an antimicrobial skin treatment composition
AT473010T (en) 2004-05-24 2010-07-15 Novozymes As Enzymes for pharmaceutical use
ITTO20040390A1 (en) 2004-06-10 2004-09-10 Roeder 1956 Farmaceutici S P A Composition, in particular for pharmaceutical use, an antioxidant action, anti-inflammatory and immunostimulant.
US20050281795A1 (en) 2004-06-17 2005-12-22 Amano Enzyme Usa., Ltd. And Amano Enzyme,Inc. Controlled release formulations of enzymes, microorganisms, and antibodies with mucoadhesive polymers
WO2006019764A2 (en) 2004-07-15 2006-02-23 Northstar Neuroscience, Inc. Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
EP1791966B1 (en) 2004-09-10 2014-06-04 Novozymes North America, Inc. Methods for preventing, removing, reducing, or disrupting biofilm
US20060198838A1 (en) 2004-09-28 2006-09-07 Fallon Joan M Combination enzyme for cystic fibrosis
US20100196344A1 (en) 2005-10-14 2010-08-05 Cystic Fibrosis Foundation Therapeutics, Inc. Compositions and methods for treating pancreatic insufficiency
WO2006044529A1 (en) 2004-10-14 2006-04-27 Altus Pharmaceuticals Inc. Compositions containing lipase; protease and amylase for treating pancreatic insufficiency
US20060115467A1 (en) 2004-12-01 2006-06-01 Pangborn Jon B Compositions and methods for the treatment of autism
US20070092501A1 (en) 2005-04-26 2007-04-26 Prothera, Inc. Compositions and methods relating to reduction of symptoms of autism
US20060258599A1 (en) 2005-04-27 2006-11-16 Melanie Childers Methods and composition for the treatment of cystic fibrosis and related illnesses
EP1901771A2 (en) 2005-06-24 2008-03-26 N-Zymeceuticals, Inc. Nattokinase for reducing whole blood viscosity
EP2278002B1 (en) 2005-07-29 2017-07-12 Abbott Laboratories GmbH Pancreatin with reduced viral content
US20070148152A1 (en) 2005-08-15 2007-06-28 George Shlieout Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
AU2006281415B2 (en) 2005-08-15 2012-01-19 Abbott Laboratories Gmbh Pancreatin micropellet cores suitable for enteric coating
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
US20070116695A1 (en) 2005-09-21 2007-05-24 Fallon Joan M Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders
US20070203426A1 (en) 2005-10-20 2007-08-30 Kover Arthur J Method and apparatus for obtaining real time emotional response data over a communications network
WO2007053619A2 (en) * 2005-11-01 2007-05-10 Bio-Cat, Inc. A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency
US8728521B2 (en) 2005-12-27 2014-05-20 Hemant N. Joshi Physically/molecularly distributed and/or chemically bound medicaments in empty, hard capsule shells
CA2637701A1 (en) 2006-02-02 2007-08-09 Dsm Ip Assets B.V. Food product comprising a proline specific protease, the preparation thereof and its use for degrading toxic or allergenic gluten peptides
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
EP2032612A1 (en) 2006-06-23 2009-03-11 Basell Poliolefine Italia S.r.l. Magnesium chloroalkolate-based catalyst precursors
US8287858B2 (en) 2006-08-10 2012-10-16 Jon Barron Proteolytic enzyme formulations
WO2008028193A2 (en) 2006-09-01 2008-03-06 Pharmion Corporation Colon-targeted oral formulations of cytidine analogs
US8066986B2 (en) 2007-02-01 2011-11-29 Master Supplements, Inc. Formulations including digestive enzymes and polysorbate surfactants that enhance the colonization of administered probiotics microoganisms
US20080199448A1 (en) 2007-02-16 2008-08-21 Ross Mairi R Enzyme composition for improving food digestion
ES2560527T3 (en) 2007-02-20 2016-02-19 Allergan Pharmaceuticals International Limited stable compositions of digestive enzymes
US20090117180A1 (en) 2007-02-20 2009-05-07 Giovanni Ortenzi Stable digestive enzyme compositions
WO2008127567A1 (en) 2007-04-13 2008-10-23 Beth Israel Deaconess Medical Center, Inc. Novel nutritional food products for improved digestion and intestinal absorption
JP2008283895A (en) 2007-05-16 2008-11-27 Kals:Kk Method for detecting diarrheagenic escherichia coli
US20090110674A1 (en) 2007-10-24 2009-04-30 Loizou Nicos C Health supplement
RU2356244C1 (en) 2007-11-12 2009-05-27 Федеральное государственное учреждение "Томский научно-исследовательский институт курортологии и физиотерапии Федерального агентства по здравоохранению и социальному развитию" (ФГУ "ТНИИКиФ Росздрава") Combination therapy of children suffering from celiac disease at health resort stage
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
US20090324730A1 (en) 2008-06-26 2009-12-31 Fallon Joan M Methods and compositions for the treatment of symptoms of complex regional pain syndrome
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
EP2318035A4 (en) 2008-07-01 2012-08-01 Curemark Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US20100169409A1 (en) 2008-08-04 2010-07-01 Fallon Joan M Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of parkinsons disease, movement and neurological disorders, and chronic pain
EP2328609A1 (en) 2008-08-26 2011-06-08 Cystic Fibrosis Foundation Therapeutics, Inc. Rapidly disintegrating tablets comprising lipase, amylase, and protease
US20100092447A1 (en) 2008-10-03 2010-04-15 Fallon Joan M Methods and compositions for the treatment of symptoms of prion diseases
AT541591T (en) 2008-11-03 2012-02-15 Nordmark Arzneimittel Gmbh & Co Kg A method for reducing the viral and microbial load of pancreatin
EP2373693A4 (en) 2009-01-06 2012-04-25 Curelon Llc Compositions and methods for the treatment or the prevention oral infections by e. coli
ES2668909T3 (en) 2009-01-06 2018-05-23 Galenagen, Llc Compositions comprising protease, amylase and lipase for use in the treatment of Staphylococcus aureus infections
EP2398470A4 (en) 2009-02-23 2013-03-06 Aptalis Pharmatech Inc Controlled-release compositions comprising a proton pump inhibitor
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
WO2011000924A1 (en) 2009-07-03 2011-01-06 Abbott Products Gmbh Spray-dried amylase, pharmaceutical preparations comprising the same and use
EP2295039B1 (en) 2009-08-28 2013-12-11 Nordmark Arzneimittel GmbH & Co.KG Method of preparing pancreatin pellets, in particular pancreatin micropellets, and pancreatin pellets prepared thereby
US20110081320A1 (en) 2009-10-06 2011-04-07 Nubiome, Inc. Treatment/Cure of Autoimmune Disease
WO2011050135A1 (en) 2009-10-21 2011-04-28 Curemark Llc Methods and compositions for the prevention and treatment of influenza
US20110112005A1 (en) 2009-11-12 2011-05-12 Alan Thomas Brooker Laundry Detergent Composition
WO2011097266A1 (en) 2010-02-02 2011-08-11 Amano Enzyme Usa, Ltd. Use of proteases for gluten intolerance
EP2547765A4 (en) 2010-03-19 2013-09-04 Aptalis Pharma Canada Inc Beta-propiolactone for inactivation of viruses in pharmaceutical pancreatic enzyme preparations
AR093181A1 (en) 2010-10-01 2015-05-27 Aptalis Pharmatech Inc Formulation containing digestive enzymes stable under
GB2503852B (en) 2011-04-21 2018-12-12 Curemark Llc Compounds for the treatment of neuropsychiatric disorders
AU2013206890B2 (en) 2012-01-03 2017-09-28 Curemark, Llc Methods of treating behavioral symptoms of neurological and mental disorders
CA2862363A1 (en) 2012-02-02 2013-08-08 Joan M. Fallon Enzyme compositions and use thereof for wound healing
US20130323223A1 (en) 2012-05-30 2013-12-05 Curemark, Llc Methods of treating celiac disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743447B2 (en) * 2000-03-29 2004-06-01 Roquette Freres Pulverulent mannitol and process for preparing it

Cited By (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9624526B2 (en) 1999-12-17 2017-04-18 Curemark Llc Method for treating pervasive development disorders
US20040071683A1 (en) * 1999-12-17 2004-04-15 Fallon Joan M. Methods for treating pervasive development disorders
US8613918B2 (en) 1999-12-17 2013-12-24 Curemark Llc Method for treating pervasive development disorders
US8211661B2 (en) 1999-12-17 2012-07-03 Curemark, Llc Method for identifying individuals having a pervasive development disorder amenable to digestive enzyme therapy
US8163278B2 (en) 1999-12-17 2012-04-24 Curemark Llc Methods for treating pervasive development disorders
US20080219966A1 (en) * 1999-12-17 2008-09-11 Fallon Joan M Methods of treating pervasive development disorders
US20090197289A1 (en) * 1999-12-17 2009-08-06 Fallon Joan M Method for confirming a diagnosis of autism
US8105584B2 (en) 1999-12-17 2012-01-31 Curemark Llc Method for treating pervasive development disorders
US8012930B2 (en) 1999-12-17 2011-09-06 Curemark, Llc Methods of treating pervasive development disorders
US8008036B2 (en) 1999-12-17 2011-08-30 Curemark, Llc Method for identifying autistic individuals amenable to digestive enzyme therapy
US20090286270A1 (en) * 1999-12-17 2009-11-19 Fallon Joan M Method for treating pervasive development disorders
US9624525B2 (en) 1999-12-17 2017-04-18 Curemark, Llc Method for treating pervasive development disorders
US8815233B2 (en) 1999-12-17 2014-08-26 Curemark Llc Method for treating pervasive development disorders
US9233146B2 (en) 2000-08-14 2016-01-12 Curemark, Llc Method of treating and diagnosing Parkinson's disease and related dysautonomic disorders
US8778335B2 (en) 2000-08-14 2014-07-15 Curemark, Llc Methods of treating and diagnosing Parkinson's disease and related dysautonomic disorders
US20090285790A1 (en) * 2000-08-14 2009-11-19 Fallon Joan M Methods of treating and diagnosing parkinsons disease and related dysautonomic disorders
US8012710B2 (en) 2000-08-14 2011-09-06 Curemark, Llc Methods of treating and diagnosing Parkinsons disease and related dysautonomic disorders
US20070053895A1 (en) * 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
US9377459B2 (en) 2000-11-16 2016-06-28 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US10209253B2 (en) 2000-11-16 2019-02-19 Curemark, Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20020081628A1 (en) * 2000-11-16 2002-06-27 Fallon Joan M. Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US8921054B2 (en) 2000-11-16 2014-12-30 Curemark, Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US8580522B2 (en) 2000-11-16 2013-11-12 Curemark, Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20080166334A1 (en) * 2004-09-28 2008-07-10 Fallon Joan M Combination enzyme for cystic fibrosis
US20100233218A1 (en) * 2004-09-28 2010-09-16 Curemark Llc Combination enzyme for cystic fibrosis
US9345721B2 (en) 2005-08-30 2016-05-24 Curemark, Llc Use of lactulose in the treatment of autism
US8673877B2 (en) 2005-08-30 2014-03-18 Curemark, Llc Use of lactulose in the treatment of autism
US20070116695A1 (en) * 2005-09-21 2007-05-24 Fallon Joan M Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders
US9925250B2 (en) 2008-03-13 2018-03-27 Curemark, Llc Method of treating proteinuria in pregnancy
US9408895B2 (en) 2008-03-13 2016-08-09 Curemark, Llc Method of treating pregnancy-induced hypertension
US9023344B2 (en) 2008-03-13 2015-05-05 Curemark, Llc Method of treating toxemia
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US20090232789A1 (en) * 2008-03-13 2009-09-17 Fallon Joan M Novel pharmaceutical preparation for preeclampsia, eclampsia, and toxemia, and their related symptoms and related disorders of pregnancy
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
US9017665B2 (en) 2008-04-18 2015-04-28 Curemark, Llc Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US8486390B2 (en) 2008-04-18 2013-07-16 Curemark Llc Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US20090263372A1 (en) * 2008-04-18 2009-10-22 Fallon Joan M Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US9687534B2 (en) 2008-04-18 2017-06-27 Curemark, Llc Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US8318158B2 (en) 2008-04-18 2012-11-27 Curemark, Llc Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
US20090324572A1 (en) * 2008-06-26 2009-12-31 Fallon Joan M Methods and compositions for the treatment of symptoms of williams syndrome
US20110182818A1 (en) * 2008-07-01 2011-07-28 Fallon Joan M Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US20100169409A1 (en) * 2008-08-04 2010-07-01 Fallon Joan M Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of parkinsons disease, movement and neurological disorders, and chronic pain
US9061033B2 (en) 2008-10-03 2015-06-23 Curemark Llc Methods and compositions for the treatment of symptoms of prion diseases
US9687535B2 (en) 2008-10-03 2017-06-27 Curemark, Llc Methods and compositions for the treatment of symptoms of prion diseases
US9895427B2 (en) 2009-01-06 2018-02-20 Galenagen, Llc Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces
US9084784B2 (en) 2009-01-06 2015-07-21 Curelon Llc Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces
US9107419B2 (en) 2009-01-06 2015-08-18 Curelon Llc Compositions and methods for treatment or prevention of Staphylococcus aureus infections and for the eradication or reduction of Staphylococcus aureus on surfaces
US9415014B2 (en) 2009-04-13 2016-08-16 Curemark, Llc Enzyme delivery systems and methods of preparation and use
US9931302B2 (en) 2009-04-13 2018-04-03 Curemark , LLC Enzyme delivery systems and methods of preparation and use
US10098844B2 (en) 2009-04-13 2018-10-16 Curemark, Llc Enzyme delivery systems and methods of preparation and use
US20100260857A1 (en) * 2009-04-13 2010-10-14 Joan Fallon Enzyme delivery systems and methods of preparation and use
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
US9511125B2 (en) 2009-10-21 2016-12-06 Curemark Llc Methods and compositions for the treatment of influenza
US9492515B2 (en) 2011-04-21 2016-11-15 Curemark, Llc Method of treatment of schizophreniform disorder
US8980252B2 (en) 2011-04-21 2015-03-17 Curemark Llc Methods of treatment of schizophrenia

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