CN1275897A - Novel powerful cosmetic or pharmaceutical composition - Google Patents
Novel powerful cosmetic or pharmaceutical composition Download PDFInfo
- Publication number
- CN1275897A CN1275897A CN98810221A CN98810221A CN1275897A CN 1275897 A CN1275897 A CN 1275897A CN 98810221 A CN98810221 A CN 98810221A CN 98810221 A CN98810221 A CN 98810221A CN 1275897 A CN1275897 A CN 1275897A
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- skin
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- crude extract
- scalp
- wound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
Abstract
The present invention relates to an extract of animal prancreas for topical application to the skin or wound which is a new, powerful, multi-function, cosmetic or pharmaceutical composition. It has a function of moisturizing skin, a function of making skin a comfortable silky smooth feel, a function of accelerating wound healing, a function of skin cleansing, a function of peeling stratum corneum, a function of treating keratoses, a function of improving tissue cell metabolism, a function of promoting cell turnover, and a function of enhancing the quality of skin or scalps cells, etc. It can be formulated with cosmetically or pharmaceutically acceptable ingredients into varied products to satisfy some cosmetic or pharmaceutical needs. The present invention also describes a method of preparing the extract of animal pancreas.
Description
Field that the present invention belongs to
This invention relates to a kind of crude extractive of animal pancreatic, and specifically to be exactly that this extract can be used as new, dynamical, multi-functional cosmetics or pharmaceutical composition.
Prior art
Pancreas has endocrine and exocrine function, so it contains many bioactive substances, as: insulin, glucagon, Somat, pancreatic polypeptide, kallikrein and pancreatin etc.Some active substance in the animal pancreatic has been used as the composition of cosmetics or accelerating wound healing.At present, this comprises kallikrein, pancreatin and insulin.
Kallikrein is used as vasodilation.It is said that it can improve the infringement (list of references Natalia Michalun etc.) of the mitosis wound healing of cell, oxygen picked-up and pre-preventing ultraviolet
Pancreatin includes plurality of enzymes, and these enzymes are authorized the activity of its water Jie protein, starch and fat.In biology stripped off, it was used as a kind of raw material and removes cuticular cell (list of references: Natalia Michalun et a1.).
(U.S. Patent number 546103 and 5591709) insulin is used as a composition of accelerating wound healing in the prescription of Lindenbaum ' s.
But other pancreas material is not clear to the effect of skin and wound.Might they aspect cosmetics and the wound healing also be a little useful materials.The extract of animal pancreatic is a mixture, and it contains many bioactive substances and other material.This extract to the effect of skin and wound also not by known to the people.May be because the extract of pancreas contains many digestive enzyme, as: trypsin, pancreas Chymotrypsin, elastin enzyme, esterase and phosphide enzyme (list of references: Chandrasoma, Underwood and Isselbacher).These enzyme general designation pancreatin, the eupepsia histiocyte in their destructives ground causes the downright bad hemorrhage of normal tissue cell.As: trypsin and pancreas Chymotrypsin can cause histiocytic necrosis and hemorrhage, the elastin enzyme causes blood vessel injury and local hemorrhage, and esterase and phosphide enzyme cause the damage (list of references: Chandrasoma and Isselbacher) of partial fat necrosis and cell membrane respectively.Though peptide hormone helps the healing of wound as insulin and kallikrein, their content in extract is less than digestive enzyme far away.This is because most pancreatic tissues is to make (the list of references: Underwood) of pancreatin, therefore, though extract contains insulin and kallikrein, this extract should be deleterious to the foreseeable effect of skin and wound, perhaps or even dangerous.Because under the situation of pancreas class, digestive enzyme also is (list of references: Chandrasoma, the Underwood and Isselbacher) that takes place under the situation that has insulin and kallikrein to exist to the injury effect of pancreas and pancreas surrounding tissue.
Purpose and advantage
This present invention has prepared a kind of extract of animal pancreatic, then it is used on partial skin and the wound.Be extract surprisingly to normal histiocyte and wound without any infringement, on the contrary, it has helped the healing of wound, improved histiocytic metabolism, promoted the renewal of cell, promoted the quality of skin, increased the water content of skin, cleaned skin and made skin that the soft and smooth sense of a kind of sample be arranged.Though extract has also stripped off the horny layer of part, this effect is a self limit, and it does not have digestion to fall all horny layer.In addition, this extract also can be used for treating many keratinization diseases such as xeroderma, also claims ichthyosis, psoriasis, and ketatosis seborrheica, acne, the dandruff also claim callus of seborrheic dermatitis and skin or the like.Above-mentioned all these the useful effect of skin and wound is all failed to be predicted, but these useful effects make it can be used as the composition of a kind of multi-functional cosmetics and medicine.
Purpose:
The objective of the invention is to provide a kind of method for preparing animal pancreatic extract, utilize this extract to be made into cosmetics or medicine is treated skin, scalp, other disease of wound and some, and find new active substance composition in this extract.
Advantage:
1. this extract has better curative effect aspect accelerating wound healing.As: when used the part, chapping on the skin can disappear in 1-2 days.This invention is different from two inventions (U.S. Patent number 5461030 and 5591709) of Lindenbaum.Because do not contain kallikrein and other some unknown compositions in his invention.
2. strip off cuticular function.But it only strips off the horny layer of part, never strips off holostrome, also never damages normal Skin Cell simultaneously, even the extract of spissated or purification has been used, also is like this.This advantage can make it can be used in the phenomenon that the material that comes the substituted hydroxy acids in cosmetics or the medicine goes to treat some skin aginges safely.Because hydroxy acid class material has many side effect to skin.The effect of stripping off of this invention may be because the effect of pancreatin in the extract.The article of Michalun has also been described pancreatin and has been stripped off cuticular effect, but he fails to disclose above-mentioned characteristics of stripping off effect.This may be exactly that pancreatin fails to be used in daily cosmetics and the reason in the medicine.Because it is very deleterious that pancreatin is considered to histiocyte always, the effect of stripping off of pancreatic extract also is different from the patent (U.S. Patent number 5554366) of Rawlings in addition.The active ingredient of Rawlings is the enzyme of the Chymotrypsin sample of keratodermatitis, and the extract in this invention does not contain the enzyme of horny layer Chymotrypsin sample.
3. it can be used to treat many keratinization diseases such as ichthyosis, psoriasis, ketatosis seborrheica, acne also claims callus of acne, scalp desquamation and skin or the like.But do not damage normal histiocyte.
4. can make skin that the soft and smooth sense of very comfortable silk sample is arranged.Thisly feel can last for days.In addition, it can make skin keep nature and healthy appearance, does not have sticking sensation or greasy appearance.
5. the effect of cleaning skin when increasing, the water content that makes skin is arranged again.As after using several days continuously, some filths that tightly are bonded in dermatoglyph and the pore just can be washed off at an easy rate.
6. can improve histiocytic metabolism, improve the quality of skin, scalp and wound, promote the renewal of cell, protect normal skin and scalp.As, it can regulate the renewal and the differentiation of horn cell, and this just makes it have antidotal effect.
7. this extract is very safe.Even extract high concentration or that be purified is used on the skin, it can not damage normal skin yet.
8. active lasting stability.Though extract contains many enzymes and hormone, their activity is very stable, at room temperature can preserve and still not lose activity more than 1 year.
General introduction:
In brief, this invention relate to find a kind of new, dynamical, multi-functional, can partially be used in cosmetics or pharmaceutical composition on skin or the wound, also provide preparation this method for compositions simultaneously.
Describe in detail:
Pancreas of many animals and solvent (water solublity and fat-soluble) can be used for preparing the extract of animal pancreatic.But pancreas, ethanol and water that I prefer with pig are manufactured.The concentration of ethanol more than 60% better, preferable is with 95% or higher concentration.
Animal pancreatic fresh or cryogenic freezing is pulverized 95% ethanol that adds 2 times of amounts, stirs, and mixes.Mixture is extracted 2-3 hour to 24 hours, and centrifugation number minute under the speed that about per minute 5,000 changes then takes out supernatant but do not bring the solid composition into.Such supernatant can be used on the skin partly to reach the purpose of skin protection, because contain too many ethanol after with the diluent dilution.In order to reduce in the extract ethanol to the stimulation of skin and wound, supernatant vacuum available pump or evaporate the ethanol concentrated extract with moving air simply.But had better not be with the extract evaporate to dryness.Because being evaporated thyraden is difficult to be dissolved fully again.So preferably extract is concentrated to its 1/4 amount.After evaporating ethanol, be concentrated to 2.5 milliliters such as 10 milliliters supernatant.This supernatant that is concentrated is exactly the extract of animal pancreatic, and it is xanchromatic liquid, comprises oil phase of a water, and pH value is between 6-7.
Embodiment:
The pancreas of 50 gram pigs are suspended in after grinding in 100 milliliter 95% the ethanol to be stirred, and at room temperature extracts 12 hours, and the speed of changeing with per minute 5,000 is centrifugal 10 minutes then, collects supernatant in clean container, but does not bring the solid composition into.About 90 milliliters supernatant can be collected.The supernatant to 22 that vacuum evaporation is 90 milliliters milliliter, at this moment the extract of animal pancreatic has just prepared.
At last the extract of animal pancreatic is mixed with various emulsions or solution with other some the approved cosmetics or the composition of medicine according to the needs of some cosmetics or medicine.
Embodiment:
The following percentage calculation of skin care liquid that is used for normal skin with weight
The extract 2.0 of animal pancreatic
16 alkane of ethyoxyl esterification and 18 acyl alcohol-20 0.2
(Ceteareth-20)
Methyl parahydroxybenzoate 0.2
Perfume is an amount of
Water adds to 100
In the daytime protective cream (day cream)
Deionized water 76.9
Acrylic acid polymer (Carbomer) 0.2
EDTA disodium 0.1
Methyl parahydroxybenzoate 0.2
Octyl methoxycinnamate 7.5
Ring first estersil 5.0
Benzophenone-3 3.0
Hard ester acid 2.0
Benzene front three estersil 1.0
Tocopheryl acetate 1.0
The hard acid ester salt 0.5 of glyceryl
Hexadecanol 0.2
Propyl p-hydroxybenzoate 0.1
Ferrum oxide 0.002
Sodium hydroxide (10 equivalent concentration) 0.3
Animal pancreatic extract 2.0
Perfume is an amount of
Pancreatic extract can not add individually dilutedly yet and directly is not used on partial skin or the scalp with other cosmetics and ingredient preparation, even uses under the situation of concentrating, and it does not cause the damage of skin or scalp yet.But the ethanol in the extract is irritant to skin or scalp.In addition, the water of extract and oil phase also can be used respectively, are perhaps used a composition and other some compositions as cosmetics and medicine to be mixed with cosmetics or medicine respectively.But its function does not just resemble the complete extract many in this case.The more function of stripping off and cleaning is arranged and oil phase has more hydration, wound healing, improves the effect of metabolism and skin moistening as the water of extract.Extract also can come some thermally sensitive active substances of deactivation to keep temperature-resistant active substance by the method for heating.As, by such heat treated, make the soft and smooth function of skin and strip off function just to be retained, because the composition that has this function in the extract is to temperature-insensitive.In addition in order to have more single-minded function, extract can be further by regulate pH value, saltout, dialysis, crystallization, chromatography or electrophoretic method to be to remove some unwanted composition, as reduce the function reduction that pH value will cause that some composition precipitation result is stripped off, raise pH value and will make that repair function weakens.By the isolated pancreatin of above-mentioned method, strip off horny layer to self limit safely and do not injure normal histiocyte.Trypsin that further is purified and pancreas Chymotrypsin also can be used to strip off horny layer.Pancreatin, Trypsin and pancreas Chymotrypsin can be used to treat many keratinization diseases, as: xeroderma also claims ichthyosis, psoriasis, ketatosis seborrheica, acne, scalp desquamation also to claim the callus on seborrheic dermatitis, the skin etc.
Animal pancreatic extract contains many active substances as insulin, glucagon, Somat, pancreatic polypeptide, kallikrein, elastin enzyme, pancreatin, fat, bile and the active substance that some is unknown.Some composition among them on function be mutual antagonism, some works in coordination with.The extract that has confirmed animal pancreatic by experiment is to be of value to very much skin, scalp and wound, and it does not damage normal histiocyte, is the very useful cosmetics and the composition of medicine therefore.But the mechanism of each composition compound action is difficult to predict that because extract contains a lot of active substances, some among them has been known some and also do not known by the people in its mechanism of action, particularly extract.As improve cellular metabolism, and promote cell to upgrade, the function that strengthens skin, scalp and wound quality and humidifying skin just can not be predicted, because the pancreatin in the extract can digest the organizational structure of skin.Skin destructurized is of value to histiocytic function and just can't sets up.Therefore perhaps the mechanism of action of animal pancreatic extract can only come inference according to experiment and practical result.Be explanation below to some the possible mechanism of action of extract.
Insulin is an anabolic hormone, so it can provide the function of accelerating wound healing, enhancement skin or scalp cells quality for extract.Kallikrein is a vasodilation; it can improve mitosis, wound healing, oxygen picked-up and the protection skin of cell and avoid ultraviolet injury (list of references: Natalia Michalun etc.); therefore it may provide the function of accelerating wound healing, and the function that strengthens skin scalp quality.Pancreatin has included several enzymes such as amylase, lipase, nuclease, peptidase, trypsin, pancreas Chymotrypsin etc.These enzymes make it the activity of hydrolyzed protein, starch and fat is arranged (list of references: Natalia Michalun etc.), so it provides the function of stripping off corneocyte and cleaning skin for extract.Fat and some other materials have makes skin keep the effect of more moisture content.
Animal pancreatic extract also contains the important active substances that some are not also known by the people at present in addition, among them some can make skin keep the hydration of long period, some unknown composition acts on pancreatin and makes skin that the soft and smooth sense of long silk sample is arranged on the skin, some composition is relevant with the function of cleaning skin, and some unknown composition has quickened wound healing with kallikrein and insulin.Some with make skin hydration and make skin that a material of the soft and smooth sense of sample be arranged, their activity all is stable in pH value scope more widely and is heat-stable.
Effect by means of above-mentioned these materials, the extract of animal pancreatic has just possessed many important function, if can strengthen the hydration of skin the long period, make skin that the soft and smooth sense of a sample be arranged, the function that promotes wound healing is arranged high-effectly, the effect of stripping off keratodermatitis is arranged, energy cleaning skin, the quality of promoting the skin scalp.These compositions that just make that it can be used as a kind of multi-functional efficiently cosmetics or medicine to be mixed with some emulsions or solution with compositions of some other approved cosmetics or medicine, with the needs that satisfy some cosmetics or pharmaceutical preparations and function widely is provided.
Use:
The compositions of this invention mainly is as such product; its topical application gets on to protect normal skin to exempt from drying at people's skin or wound; make skin return to the softish state of a hydration health, deep; treat exsiccant skin; alleviate scalp desquamation; accelerating wound healing makes skin that a soft and smooth sense of silk sample as snug as a bug in a rug, quality of cleaning skin and enhancement skin, scalp cells or the like be arranged.
Usage:
0.5 milliliter to 5 milliliters mixture is used on skin, scalp or the wound, in crumpling with hands, finger or other instrument then.
Conclusion and scope:
By above-mentioned introduce extract that the reader will know this invention be a goodish multi-functional cosmetics or pharmaceutical composition; it can be used to protect normal skin to avoid dry; make skin return to the softish state of healthy hydration; can treat xerosis cutis; alleviate seborrheic dermatitis, for skin stays the soft and smooth sense of a sample, cleaning skin; accelerating wound healing is promoted quality of skin, scalp or the like.It also can with many cosmetics on and the composition of pharmaceutical preparations approval formulated together so that function more widely to be provided, and it has following advantage.
It can make skin maintenance hydration for a long time;
It makes skin keep the sensation and the appearance of natural health;
It provides the long-time comfortable soft and smooth sense of silk sample for the skin of user;
It has the function of cleaning skin;
It has the function of stripping off horn cell;
It is promoting aspect the wound healing better curative effect is arranged;
It can promote the quality of skin, scalp cells;
Therefore it provides multi-functional protective effect for skin, has saved the time and cost has made things convenient for the user.
Though above-mentioned description includes many concrete features,, these should not be considered to the limitation of the scope of the invention factor, and should be used as it the example of preferred version of the present invention.Many other variations all are possible.Also can be used for other wound as it to the effect of wound healing, the wound of transplanting as burn wound, histoorgan etc., it also has the effect of debridement when it is used to wound healing, because it contains pancreatin.It also can be formulated into 70% ethanol and include the 10-13% animal pancreatic extract and formulate out a new disinfectant.This disinfectant skin of promptly having sterilized has prevented that also the fat layer of skin surface from avoiding the degraded of ethanol.
Therefore this scope of invention should not determined by described embodiment and should be decided by claim of being enclosed and their law equivalents.
Claims (20)
1. method for preparing the animal pancreatic crude extract, described crude extract is as cosmetics or ingredient, and this method may further comprise the steps:
(a) pancreas of any animal that will pulverize is suspended in the solvent,
(b) extracted this mixture several hours to 24 hours or longer, and
(c) collect supernatant, thereby obtain the described crude extract of animal pancreatic.
2. the process of claim 1 wherein that described animal pancreatic is the Pancreas Sus domestica gland.
3. the process of claim 1 wherein that described solvent comprises fat-soluble and water-soluble solvent.
4. the method for claim 3, wherein said fat-soluble solvent is an ethanol, described water-soluble solvent is ethanol and water.
5. local be used for skin, scalp or wound, treatment drying chap skin, protect normal skin, make skin that the soft and smooth sense of a sample, accelerating wound healing be arranged, strip off corneocyte, treatment keratosis, cleaning skin, improve the histiocyte metabolism, promote cell to upgrade or improve the compositions of skin, scalp or wound quality, it comprises the animal pancreatic crude extract.
6. the compositions of claim 5, wherein said part are used for skin or scalp treatment or protection compositions normal, dry, the skin of chapping and comprise at least a composition of described crude extract.
7. the compositions of claim 5, wherein said part is used for skin makes skin have a compositions of the soft and smooth sense of sample to comprise at least a composition of described crude extract.
8. the compositions that the compositions of claim 5, wherein said part are used for the wound accelerating wound healing comprises at least a composition of described crude extract.
9. the compositions of claim 5, wherein said part are used at least a composition that compositions that skin, scalp or wound improve the histiocyte metabolism, promote cell to upgrade or improve skin, scalp or wound quality comprises described crude extract.
10. the compositions that the compositions of claim 5, wherein said part are used for skin, scalp or wound clean skin, scalp or wound comprises at least a composition of described crude extract.
11. the compositions of claim 5, wherein said part are used for skin or scalp strips off corneocyte or treats at least a composition that keratotic compositions comprises described crude extract.
Strip off corneocyte or treat keratotic compositions 12. the compositions of claim 5, wherein said part are used for skin, comprise the trypsin or the Chymotrypsin of described crude extract.
13. a protection normal skin, make skin have the soft and smooth sense of a sample, treatment drying chap skin, add wound healing, strip off corneocyte, treatment keratosis, cleaning skin, improve the histiocyte metabolism, promote cell to upgrade or improve skin or scalp method for quality, comprise the crude extract of animal pancreatic.
14. also comprising making, the method for claim 13, wherein said method apply some make up or composition that medicine is used contains the cosmetics or the medicine of at least a or whole one-tenth branches of described crude extract with preparation.
15. the method for claim 13, wherein said protection or treatment method normal, dry or the skin of chapping comprise the compositions that contains at least a composition of described crude extract to skin or scalp local application.
16. comprising to wound, the method for claim 13, the method for wherein said accelerating wound healing use the compositions that contains at least a composition of described crude extract.
17. the method for claim 13, wherein said strip off corneocyte or treat keratotic method comprise to skin or scalp and use the compositions that contains at least a composition of described crude extract.
18. the method for claim 13, the wherein said skin that makes has a method of the soft and smooth sense of sample to comprise the compositions that contains at least a composition of described crude extract to dermal administration.
19. the method for claim 13 is wherein saidly improved the histiocyte metabolism, promotes cell to upgrade or improve skin, scalp or wound method for quality to comprise the compositions that contains at least a composition of described crude extract to skin, scalp or wound local application.
20. stripping off corneocyte or treat keratotic method, the method for claim 13, wherein said safety comprise the compositions that contains the pancreatin of described crude extract to skin or scalp local application.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95193397A | 1997-10-16 | 1997-10-16 | |
| US14892198A | 1998-09-04 | 1998-09-04 | |
| US09/148,921 | 1998-09-04 | ||
| US08/951,933 | 1998-09-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1275897A true CN1275897A (en) | 2000-12-06 |
Family
ID=26846306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98810221A Pending CN1275897A (en) | 1997-10-16 | 1998-10-15 | Novel powerful cosmetic or pharmaceutical composition |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1051142A4 (en) |
| JP (1) | JP2002509855A (en) |
| KR (1) | KR20010031170A (en) |
| CN (1) | CN1275897A (en) |
| CA (1) | CA2305507A1 (en) |
| WO (1) | WO1999018920A1 (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002051352A2 (en) * | 2000-12-26 | 2002-07-04 | Yao Zhu | New uses of insulin and pancreatin |
| CN103405751A (en) * | 2013-08-22 | 2013-11-27 | 赵轩 | Composition with cell repairing function and preparation method and application thereof |
| CN105605329A (en) * | 2015-10-09 | 2016-05-25 | 武汉武船机电设备有限责任公司 | Flange connecting cabin penetration pipe fitting |
| CN107261126A (en) * | 2012-02-02 | 2017-10-20 | 加尔纳根有限责任公司 | Enzymatic compositions and its purposes for wound healing |
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|---|---|---|---|---|
| EP1383540B1 (en) | 2000-07-31 | 2009-04-29 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
| US20040037828A1 (en) | 2002-07-09 | 2004-02-26 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
| CA2535029C (en) | 2003-08-07 | 2013-07-16 | Healor Ltd. | Pharmaceutical compositions and methods for accelerating wound healing |
| US20110104240A1 (en) * | 2008-06-24 | 2011-05-05 | Micropharma Limited | Nitric Oxide Device and Method for Wound Healing, Treatment of Dermatological Disorders and Microbial Infections |
| JP6244578B2 (en) * | 2012-03-29 | 2017-12-13 | 太邦株式会社 | Water-soluble royal jelly and method for producing the same |
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| JPS6191133A (en) * | 1984-10-11 | 1986-05-09 | Eisai Co Ltd | Agent for improving dermatic metabolism |
| US5591709A (en) * | 1991-08-30 | 1997-01-07 | Life Medical Sciences, Inc. | Compositions and methods for treating wounds |
| CN1106254A (en) * | 1994-01-24 | 1995-08-09 | 徐德茂 | Pancreatinum skin protecting and face-care cosmetics and its prodn. method |
-
1998
- 1998-10-15 JP JP2000515558A patent/JP2002509855A/en active Pending
- 1998-10-15 CN CN98810221A patent/CN1275897A/en active Pending
- 1998-10-15 WO PCT/US1998/021794 patent/WO1999018920A1/en not_active Application Discontinuation
- 1998-10-15 EP EP98952317A patent/EP1051142A4/en not_active Withdrawn
- 1998-10-15 KR KR1020007004092A patent/KR20010031170A/en not_active Application Discontinuation
- 1998-10-15 CA CA002305507A patent/CA2305507A1/en not_active Abandoned
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|---|---|---|---|---|
| WO2002051352A2 (en) * | 2000-12-26 | 2002-07-04 | Yao Zhu | New uses of insulin and pancreatin |
| WO2002051352A3 (en) * | 2000-12-26 | 2002-11-07 | Yao Zhu | New uses of insulin and pancreatin |
| US11033563B2 (en) | 2005-08-30 | 2021-06-15 | Curemark, Llc | Use of lactulose in the treatment of autism |
| US11045527B2 (en) | 2008-03-13 | 2021-06-29 | Curemark, Llc | Method of diagnosing preeclampsia or pregnancy-induced hypertension |
| US11235038B2 (en) | 2008-04-18 | 2022-02-01 | Curemark, Llc | Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same |
| US11016104B2 (en) | 2008-07-01 | 2021-05-25 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
| US11357835B2 (en) | 2009-01-06 | 2022-06-14 | Galenagen, Llc | Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces |
| US11419821B2 (en) | 2009-04-13 | 2022-08-23 | Curemark, Llc | Enzyme delivery systems and methods of preparation and use |
| US10940187B2 (en) | 2011-04-21 | 2021-03-09 | Curemark, Llc | Method of treatment of schizophreniform disorder |
| CN107261126A (en) * | 2012-02-02 | 2017-10-20 | 加尔纳根有限责任公司 | Enzymatic compositions and its purposes for wound healing |
| US11364287B2 (en) | 2012-05-30 | 2022-06-21 | Curemark, Llc | Methods of treating celiac disease |
| CN103405751A (en) * | 2013-08-22 | 2013-11-27 | 赵轩 | Composition with cell repairing function and preparation method and application thereof |
| CN105605329A (en) * | 2015-10-09 | 2016-05-25 | 武汉武船机电设备有限责任公司 | Flange connecting cabin penetration pipe fitting |
| US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010031170A (en) | 2001-04-16 |
| CA2305507A1 (en) | 1999-04-22 |
| WO1999018920A1 (en) | 1999-04-22 |
| EP1051142A4 (en) | 2002-01-30 |
| EP1051142A1 (en) | 2000-11-15 |
| JP2002509855A (en) | 2002-04-02 |
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