CN1112831A - Long lasting multi-function nutritive skin care liquid containing extract of snail and the mfg. method - Google Patents
Long lasting multi-function nutritive skin care liquid containing extract of snail and the mfg. method Download PDFInfo
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Abstract
The skin care liquid uses snail extract as main ingredient and is added with "gongbaosu", liposome SOD, epidergrowing factor, liquid extracted from turtle, mink oil, hickory nut oil, ginseng extract liquid, towel gourd juice, cucumber juice, aloes, rutin etc., it has effect of eliminating freckles and wrinkle, moistening the skin and relieving inflammation.
Description
The present invention relates to contain beauty and skin care water and method for making thereof in the cosmetic field of pure natural animals and plants extract.
Surfactant is beauty care new varieties in the modern cosmetics, because it has easily by the skin fast Absorption, after the use, dermal sensation is salubrious, and is moist, advantages such as no greasy feeling, thereby accepted by people and like very soon.But present product in the use, is confined to oily skin, generally only is applicable to summer on service time, can only the erasing in evening.On function, common commercially available surfactant only has one to two kind of effect, as moisten, skin protection, common product does not have positive effect or to no effect in a short time.Secondly contain ethanol and synthetic food color in most of surfactant, skin is had certain zest, easily cause allergic reaction.Wherein water content is at 79-90%, and nutrition is few, so be difficult to play skin care, skin effect.
Full snail skin-care nutrient liquid (CN93108664.7) is a kind of nutritive water of the face-nursing function of beauty and skin care preferably, but the nutrition of its composition is still comprehensive inadequately and desirable to the effect of beauty treatment (as eliminating freckle, chloasma, black speck, senile plaque, brightening) skin protection (as sun-proof, skin care, anti-aging) and skin care.
For overcoming in the surfactant shortcoming, break when using, be subjected to the limitation of time in season and the shortcoming of function singleness.The object of the invention, be Main Ingredients and Appearance with the snail extract and add multiple extract with natural animal-plant of beauty treatment, skin care, skin care effect, and the processing technology thereof of the science of employing, develop a kind of skin type that is not subjected to, use restrictions such as season, time, and have multi-functional comprehensive beauty treatment, skin care, skin care effect.
Skin is the organ that covers the human body surface maximum, and its gross area has 1.5-2.0M approximately in the adult
2, the physiological function of skin has multiple functions such as protection, sensation, absorption, drainage, secretion, regulate body temperature.Especially the horny layer of epidermis is the barrier of the appearance of skin.Densification is tough and tensile can resist various chemistry.Infringement such as physics and microorganism.Any undue stimulation and damage can both destroy the complete of epidermis and weaken or lose protective effect to skin.Therefore the skin of keeping fit is essential to everyone.Human body skin is again the key factor of outward appearance U.S. in addition.The situation of human body skin varies with each individual again as the difference of skins such as delicate, bright and clean, soft, elasticity, spot, also has because of external environment, and physiological change, age growth, multiple factor such as heredity, and produce phenomenons such as dry and cracked, wrinkle, acne.As use the biological beauty cosmetics of some being rich in nutrition composition, carry out the science maintenance and then might improve, thereby reach the effect of beauty treatment, skin care, skin protection skin U.S.A.
Surfactant of the present invention has been selected for use and can be skin and provide full nutrition composition pure natural biological product as Main Ingredients and Appearance and additive.Because its structure and the very close sibship of human body cell, its nutrition is very easily by the very fast absorption of human body skin, and the raw material of various effects all allocated into more than three kinds, in prescription based on Limax cattle extracting solution, be better than water-based skin care water fully, do not add any to skin and the disadvantageous synthetic chemistry raw material of human body, through repeatedly screening prescription and scientific experiments, select compatibility for use, all good and significant raw material prescription preparation becoming of the synergy surfactant of intermiscibility.
The surfactant that contains snail extract of the present invention, wherein contain following component (weight %):
Optimum content (weight %)
1, Limax mucin extracting solution 40-70 55
2, Snailase extracting solution 0.5-10 5
3, Sucus Cucumidis sativi 1-20 8
4, Sucus Luffae 0-20 5
5, GONGBAOSU 0.5-10 3
6, the refining hickory oil 0.5-5 1.5 of ethoxylation
7, the superfine mink oil 0.5-5 1 of ethoxylation
8, liposome-SOD (activity: the 0.1-3 1 of 2000 units/ml)
9, glycerol 0.5-5 1
10, sorbitol 0.5-5 1
11, active dew of Chinese soft-shelled turtle 0.1-1.5 0.5
12, Radix Ginseng extractive solution 0.05-5 0.5
13, hyaluronic acid (molecular weight: 1 * 10
6Dalton) 0.01-2 1
14, aloe liquid 0.05-3 0.2
15, rutin 0.05-3 0.3
16, gallic acid 0.05-1.5 0.5
17, tween 20 0.1-1.5 0.3
18, LI911 antiseptic 0.1-0.5 0.2
19, essence 0.05-0.3 0.1
20, vitamin C 0.01-0.5 0.02
21, zinc metallothionein 1-50ppm 5ppm
22, tea polyphenols 30-300ppm 100ppm
23, epidermal growth factor (molecular weight: 6 * 10
3Dalton) 5ppb-2ppm 5ppb
24, organic germanium 20-400ppm 300ppm
25, retinoic acid 2-200ppm 200ppm
The Main Ingredients and Appearance of surfactant of the present invention and the pure natural biological product in the additive are described as follows:
Snail extract stock solution:
The Main Ingredients and Appearance of surfactant of the present invention comprises and has adopted Limax cattle nutrition extracting solution (CN93108656.6), be that the Limax mucin extracting solution of Carnis Limax extraction and the Snailase extracting solution of Limax internal organs extraction all contain rich in protein, especially contain diversification nutritions such as multiple human body essential amino acid, good bioactive Snailase, very easily by the human body fast Absorption.Except that having nutritve function, also have skin moistening, skin care, clean skin function, can also exclude free radical, can resist ultraviolet after being applied to skin surface, have effect significantly crease-resistant, sun-proof, that prevent skin aging.
Main additive all is the elite that natural animal-plant extracted, for example:
1, GONGBAOSU (GD-1221): be the human placenta extract.Blood circulation promoting and glandular integumentaria function are arranged, preserve moisture, improve the Telatrophy of cortex, reduce wrinkle and make the cicatrix atrophy, subdue the melanocyte mottle.
2, the refining hickory oil of ethoxylation: contain and enrich vitamin E, linoleic acid, linolenic acid, the life-span of prolongation erythrocyte is moistened epidermis cell and horny layer in blood circulation.
3, the superfine mink oil of ethoxylation: form by fatty oil under the standard mink skin is refining.Its physicochemical property is similar to organization of human body, and skin care makes it tender and high resilience prevents wrinkled skin.
4, liposome-SOD(Superoxide dismutase): similar cell, by with intercellular mutual absorption, have and merge and endocytosis, compose living cells, soften and strengthen cuticular protection capability, removing causes the free radical of skin aging, and dredging pore suppresses the aging of skin.
5, active dew of Chinese soft-shelled turtle: preserve moisture, skin care has superior bioactive, film property, and breathability, conditioning skin is built up resistance, sun-proof, cold-resistant heat, acid and alkali-resistance is eliminated wrinkle, suppresses old and feeble.
6, Radix Ginseng extractive solution: skin care, promote cell proliferation, defying age strengthens high temperature resistance, low temperature, the radiation of skin, the ability of inhibiting bacteria and diminishing inflammation.
7, hyaluronic acid: extract and get by cockscomb and umbilical cord.Powerful wetting agent, absorption enhancer can keep himself moisture content up to 500 times, makes skin keep optimum humidity, accelerates blood circulation, strengthens skin elasticity, and wrinkle removing, crease-resistant makes skin moist, and is refreshing clean.
8, Aloe: the natural sun-prevention agent, preserve moisture, skin moistening, prevent and treat acne, acne, dispelling stain.
9, rutin: the efficiency natural sunscreen, the ultraviolet that wavelength 330-400nm is shone the black area has special high-absorbable, keeps skin histology, and is anti-tanned, skin whitening.
10, Sucus Luffae: tender skin strengthens skin elasticity, antiinflammatory, antiallergic.
11, Sucus Cucumidis sativi: receive stricture of vagina, moisten preserve moisture, salubrious skin, unfold wrinkle.
12, tea polyphenols: have strong antioxidant action, the activity of protection readily oxidizable substance is given anti-its oxidation, and inactivation is removed free radical, and is antibacterial, defying age.
13, epidermal growth factor-EGF(Fpidermal Growty Factor): from the nascent isolating goods of stot submaxillary gland.The multi-functional augmentor of specially good effect has the unique biological effect, can intensify the division and the propagation of epidermis cell, makes regenerative cell replace aged cells rapidly.Promote the growth of the cornea tissue of epidermis, prevent the hair follicle inflammation, wrinkle of skin and spot are eliminated in the growth of acne and comedo, to reduce the content of melanin and coloured corpuscle in the skin, eliminate the melanocyte mottle by short nearly new old and metabolism.
In cosmetics, add epidermal growth factor, hyaluronic acid, synergism each other can produce the good effect that multiple multiplies each other, skin whitening, defying age.
The snail skin-care water that contains of the present invention is to keep the wherein activity of composition, and its processing preparation steps is as follows:
1, part material produces
(1) Radix Ginseng extractive solution
Radix Ginseng is cleaned, section, and in enamelled vessel with cover by Radix Ginseng: water is the 1:2(weight portion) add sterilized water, decoct after 4-5 hour, Radix Ginseng is smashed to pieces, boil again to water and be kept at 1/2 o'clock, stop to heat, add 0.2% antiseptic after the cooling.
(2) rutin
With the Sophora japonica L. alabastrum, add the extraction of 95% soak with ethanol and form.
(3) Sucus Luffae
Clean with fresh and tender Fructus Luffae, through rubbing, press juice, filtration, slagging-off, get pure Sucus Luffae, the juice that also can get bright towel gourd stem replaces Sucus Luffae, perhaps mixes use with towel gourd stem with pure Sucus Luffae, as the very grave available activated carbon decolorizing of color.Store after the preservative treatment.
(4) Sucus Cucumidis sativi (green cucumber juice)
Get the cadmium yellow melon and clean fresh-keeping storage after fragmentation, grinding, extruding, extracting juice, filtration, slagging-off, preservative treatment.
2, raw material gives processing:
(2.1) epidermal growth factor (EGF)
Epidermal growth factor (EGF) lyophilized powder with 5 ℃ of-10 ℃ of physiological saline solutions, is diluted to the solution of 10PPm, deposits standby at 0 ℃-4 ℃.
(2.2) hyaluronic acid (molecular weight: 1 * 10
6):
In the sterilized water that stirs rapidly, slowly add hyaluronic acid and be mixed with 10% hyaluronic acid serosity, also can hyaluronic acid-like or hyaluronate sodium replacement hyaluronic acid.
(2.3) the refining hickory oil of ethoxylation, the superfine mink oil of ethoxylation: the two is weighed respectively by raw material: water is the 1:1(weight portion) be made into diluent, heat 80 ℃-90 ℃ respectively, keep sterilization in 20-30 minute.
(2.4) active dew of Chinese soft-shelled turtle, liposome-SOD(activity: 2000 units/ml), aloe liquid and rutin: with above-mentioned four kinds of raw materials after sterilizing room takes by weighing each raw material respectively, by raw material: water is the 1:1(weight portion) add the sterilized water dissolving, add 0.2% antiseptic.
(2.5) glycerol, sorbitol, vitamin C, organic germanium, retinoic acid, zinc metallothionein, gallic acid take by weighing each raw material and respectively add a small amount of sterilized water wiring solution-forming, mix homogeneously.
(2.6) Radix Ginseng extractive solution and rutin are added sterilized water dilution and dissolving adding antiseptic respectively.
3, the processing of surfactant preparation:
(3.1) under agitation successively with 2, pretreated glycerol, sorbitol mixed diluting liquid, with dissolved vitamin C, organic germanium, retinoic acid, zinc metallothionein, tea polyphenols, gallic acid, Sucus Cucumidis sativi, Sucus Luffae join in the material-compound tank of the mixed liquor that is placed with Limax mucin extracting solution and Snailase extracting solution, stir, after coarse filtration machine coarse filtration, stay coarse filtration liquid.
(3.2) under aseptic condition, (3.1) coarse filtration liquid input hollow-fibre ultrafiltration device is carried out ultrafiltration, import in the material-compound tank then.
(3.3) under agitation will be molten that prepare and at the superfine mink oil of the refining hickory oil ethoxylation of the ethoxylation behind high temperature sterilize, and active dew of Chinese soft-shelled turtle, GONGBAOSU, aloe liquid, liposome-SOD, Radix Ginseng extractive solution, rutin adds in the material-compound tank of (3.2) successively, and stirs.
(3.4) with the pH value of mixed liquor in the vitamin C adjusting material-compound tank, making its control PH is 4.5-4.8.
(3.5) under agitation add successively to have given and handle and the hyaluronic acid serosity and the epidermal growth factor mixed liquor of mix homogeneously, by 2% of adjuvant amount add antiseptic and through the essence of tween 20 solubilising in material-compound tank, and stir.
(3.6) using sterilized water to add material-compound tank to total amount is that 100 parts (weight) stir, and used sterilized water is meant the deionized water through ion exchange resin treatment, again the water after the hollow-fibre ultrafiltration device ultrafiltration.
It is the prescription of its main component and additive that surfactant of the present invention adopts nutritious pure natural biological product, processes through the advanced person is formulated, kept the active ingredient in the natural biological goods wherein, show that through on probation the multiple nutrients component of adding has outstanding synergy, broken the limitation of " different skin, different selections; different time; different maintenances, different seasons, the different use " of present cosmetics.Make its various ages that are applicable to different sexes, can both be suitable in 24 hours of all kinds of skins (oiliness, dryness, neutrality) all seasons.On effect, have multi-functional comprehensive beautification function, mainly contain the elimination freckle, chloasma, mottle, black speck, senile plaque brightens, sun-proof, skin care, anti-aging, eliminate and the minimizing wrinkle, increase skin elasticity, prevent xerosis cutis, keep moisture of skin, promote skin metabolism, compose living cells, remove the skin free radical, prevent the growth of acne and comedo, multiple efficacies such as inhibiting bacteria and diminishing inflammation.Having changed in the past, cosmetics add the few and single situation of effect of nutrient kind.Be that present any surfactant is incomparable.In prescription, be substrate, definitely be better than water base surfactant, do not add any pigment and the disadvantageous synthetics of human body with Limax cattle extracting solution.Use the back without any side effects to skin.On manufacturing process, adopt the technology of the efficient degerming of hollow-fibre membrane, make its assorted bacterial content≤10/ml(national standard be≤500/ml, American-European standard be≤100/ml).
Example 1
Take by weighing Radix Ginseng 50g, clean, be cut into fine, put into enamelled vessel with cover and add the aseptic decocting in water of 100g and stopped heating in 5 hours after (slow fire), Radix Ginseng is smashed to pieces, reheat boils to remaining 1/2 o'clock of water wherein, stop heating, filter, add the 0.1gLI911 antiseptic after the cooling, get the 50g Radix Ginseng extractive solution.
Example 2: the producing of rutin
Get fresh Sophora japonica L. alabastrum 150g and in enamelled vessel, add 95% ethanol (not having alabastrum to exceed) with liquid level, 0.75g tween 20, mixed liquor is poured in the ceramic mortar, fine being ground to till the granule of the residual body of alabastrum less than 1mm, lixiviate 4 hours, then suspension is filtered with bottle,suction, the light green clear liquor that obtains joined in the alembic distill, vapo(u)rizing temperature is controlled at below 80 ℃, after distillating ethanol rutin crude product remaining in the flask is used activated carbon decolorizing with sterilized water (being deionized water, again through ultrafiltration apparatus ultrafiltration water once) cleaning three times (anhydrating with the separatory funnel branch) at every turn.
The rutin that cleans up is added the crystallization again of 95% ethanol for thick mouthful, obtain the pure product of rutin of 30g pistac.
Example 3
Win fresh and tender Fructus Luffae 1000g, clean thinly slicing with machinery is twisted into the filling shape, is squeezed into juice, and filter and remove residue then gets the 500g Sucus Luffae, adds the 1gLI911 antiseptic.
Example 4
Select overhead nearer towel gourd stem, firmly cut through, and then with clean bottle, be enclosed within bottle neck on the otch of towel gourd stem, in order to prevent to infilter rainwater or creep into insect, bottleneck will be obturaged with adhesive plaster, with a microscler bottle half under it is embedded in the soil earlier, fixed, adopt to such an extent that Fructus Luffae antiperspirant is placed a night, coarse filtration is standby.
Example 5
It is broken that cadmium yellow (green grass or young crops) melon 1330g is cleaned the back, grind, and the extruding extracting juice, filter cleaner gets bright Sucus Cucumidis sativi 800g.Add the 1.6gLI911 antiseptic.
The preparation of example 6 surfactant
1, raw material gives processing
(1) claims with 0.005g epidermal growth factor (molecular weight: 6 * 10
3Dalton Nanjing Ba Ji biological engineering company limited product) lyophilized powder is dissolved into 10PPm solution in 0.2% vitamin c solution with 50g under 5 ℃ of-10 ℃ of temperature, and it is standby that the placement refrigerator and cooled is hidden the chamber.
(2) slowly add 50g hyaluronic acid (molecular weight: 1 * 10 under in the 450g sterilized water, stirring rapidly with 1000r/min
6Southern Shandong chemical plant, Laiyang, Shandong product) dissolving is evenly standby.
(3) the refining hickory oil (Dalian hollow biochemical product company product) of 50g ethoxylation is added the 50g sterilized water, the superfine mink oil of 100g ethoxyquin base (Dalian hollow biochemical product company product) adds the 100g sterilized water, and it is standby to carry out ℃ degerming in 20 minutes of dissolved dilution mixing post-heating to 90 respectively.
(4) take by weighing active dew of Chinese soft-shelled turtle (Changzhou Trionyx sinensis (Wiegmann) development company product) 50g in sterilizing room, liposome-SOD(GP1218 activity: 2000 list/ml Shanxi Coleman Biochemical Engineering companies product) GONGBAOSU (difficult to understand sharp chemical plant, GD-1221 Shanghai produces) 300g aloe liquid (development company of Kunming plant institute of Chinese Academy of Sciences goods) 20g presses the 1:1(weight portion respectively) dissolving of adding 20g sterilized water, dilution, and add the 1.9gLI911 antiseptic.
(5) take by weighing glycerol (cosmetics-stage) 100g sorbitol (content 〉=91%, Nof Corp. produces) 100g Catergen .5g, organic germanium (C-Ge-132 Beijing Chemical Factory of Daily Use system) 3g, retinoic acid (hold up along chemical reagent work and produce) 2g, zinc metallothionein (Beijing Ke Hai medical treatment bio-engineering corporation produces) 0.05g, tea polyphenols-East Asia, 40(Hangzhou tea polyphenols factory produces) 1g, gallic acid cosmetics-stage (production of zunyi, guizhou second chemical plant) 50g adds a small amount of sterilized water dissolving respectively and mixes.
(6) the Radix Ginseng extractive solution 50g with example 1 adds a small amount of sterilized water dilution, and the rutin 30g of example 3 dissolves and add the LI911 antiseptic of 0.2g with sterilized water.
The preparation of surfactant in the following order
(7) get * Limax mucin extracting solution 5500g and Snailase extracting solution 500g mixing and hydrolysis and fully carry out coarse filtration in back (placing two days), mixed solution with (5) mixes mutually then, the Sucus Luffae 500g that adds example 3, the bright Sucus Cucumidis sativi 800g mixing of example 5 is used 100,000 molecular weight polysulfone hollow fibre ultrafiltration apparatus heat sterilizations jointly.
(8) will mix in the filtrate input material-compound tank through (7) after the ultrafiltration, under the stirring of 100r/min, add the refining hickory oil of the molten ethoxylation of joining and sterilizing successively, the superfine mink oil of ethoxylation, active dew of Chinese soft-shelled turtle, GONGBAOSU, Aloe, liposome-SOD solution.
(9) regulate the pH value of material-compound tank at 4.6-4.8 with vitamin C.
(10) under 100r/min stirs, continue adding and given processing and blended hyaluronic acid, epidermal growth factor also stirred 10 minutes with 300r/min, add 3.5gLI911 antiseptic and essence 10g again, tween 20 30g, add sterilized water to 10Kg, and stir, promptly make the surfactant that 10Kg contains snail extract.
* Limax mucin extracting solution and Snailase extracting solution are produced by the famous science, industry and trade in Inner Mongol group head office
Claims (9)
1, a kind of surfactant that contains snail extract is characterized in that surfactant contains following component (weight %):
1, Limax mucin extracting solution 40-70
2, Snailase extracting solution 0.5-10
3, Sucus Cucumidis sativi 1-20
4, Sucus Luffae 0-20
5, GONGBAOSU 0.5-10
6, the refining hickory oil 0.5-5 of ethoxylation
7, the superfine mink oil 0.5-5 of ethoxylation
8, liposome-SOD (activity: the 0.1-3 of 2000 units/ml)
9, glycerol 0.5-5
10, sorbitol 0.5-5
11, active dew of Chinese soft-shelled turtle 0.1-1.5
12, Radix Ginseng extractive solution 0.05-5
13, hyaluronic acid (molecular weight 1 * 10
6Dalton) 0.01-2
14, aloe liquid 0.05-3
15, rutin 0.05-3
16, gallic acid 0.05-1.5
17, tween 20 0.1-1.5
18, LI9111 antiseptic 0.1-0.5
19, essence 0.05-0.3
20, vitamin C 0.01-0.5
21, zinc metallothionein 1-50ppm
22, tea polyphenols 30-300ppm
23, epidermal growth factor (molecular weight 1 * 10
3Dalton) 5ppb-2ppm
24, organic germanium 20-400ppm
25, retinoic acid 2-200ppm
2, the surfactant that contains snail extract as claimed in claim 1 is characterized in that described surfactant contains the optimum content of component (weight) and is:
1, Limax mucin extracting solution 55
2, the Snailase extracting solution 5
3, Sucus Cucumidis sativi 8
4, Sucus Luffae 5
5, GONGBAOSU 3
6, the refining hickory oil 1.5 of ethoxylation
7, the superfine mink oil 1 of ethoxylation
8, liposome-SOD(activity: 2000 units/ml) 3
9, glycerol 1
10, sorbitol 1
11, active dew of Chinese soft-shelled turtle 0.5
12, the Radix Ginseng extractive solution 0.5
13, hyaluronic acid (molecular weight 1 * 10
6Dalton) 1
14, aloe liquid 0.2
15, rutin 0.3
16, gallic acid 0.5
17, tween 20 0.3
18, the LI911 antiseptic 0.2
19, essence 0.1
20, vitamin C 0.02
21, zinc metallothionein 5ppm
22, tea polyphenols 100ppm
23, epidermal growth factor 5ppb
24, organic germanium 300ppm
25, retinoic acid 200ppm
3,, it is characterized in that described Sucus Luffae is that Fructus Luffae is through rubbing, press the pure Sucus Luffae of juice, filter cleaner as claim 1, the 2 described surfactant that contain snail extract.
4, the surfactant that contains snail extract as claimed in claim 3 is characterized in that described Sucus Luffae, and juice that can towel gourd stem or towel gourd stem juice replace with the juice that mixes of pure Sucus Luffae.
5, as claim 1, the 2 described surfactant that contain snail extract, it is characterized in that described Radix Ginseng extractive solution is by Radix Ginseng: water is the 1:2(weight portion) add sterilized water, decoct, reduce to 1/2 to water, adding preservative agent is made.
6,, it is characterized in that described hyaluronic acid can be with any replacement in hyaluronic acid-like and the hyaluronate sodium as claim 1, the 2 described surfactant that contain snail extract.
7, as claim 1, the 2 described surfactant that contain snail extract, it is characterized in that described organic germanium is C-Ge-132.
8, a kind of described method that contains the surfactant of snail extract of claim 1 for preparing is characterized in that the concrete steps of its method are as follows:
(1) raw material gives processing:
(1.1) with the epidermal growth factor lyophilized powder with 5 ℃ of-10 ℃ of physiological saline solutions, be diluted to 10ppm solution, deposit standby at 0 ℃-4 ℃;
(1.2) sterilized water is made into 10% hyaluronic acid serosity;
(1.3) respectively with the refining hickory oil of ethoxylation, the special mink oil of ethoxylation by raw material: water is the 1:1(weight portion) add water and be made into diluent, be heated to 80-90 ℃, kept 20-30 minute;
(1.4) active dew of Chinese soft-shelled turtle, liposome-SOD(2000 unit/ml), GONGBAOSU, aloe liquid are by raw material: water is the 1:1(weight fraction) be dissolved in water;
(1.5) glycerol, sorbitol, vitamin C, organic germanium, retinoic acid, zinc metallothionein, gallic acid respectively add a small amount of sterilized water dissolved dilution, and mixing;
(1.6) with Radix Ginseng extractive solution and rutin difference thin up and dissolving adding antiseptic;
(2) preparation steps of surfactant:
(2.1) stir down, the glycerol, sorbitol, vitamin C, organic germanium, retinoic acid, zinc metallothionein, gallic acid mixed liquor, Sucus Cucumidis sativi, the Sucus Luffae that successively (1) are given processing join in the snail extract, stir evenly, and coarse filtration is stayed coarse filtration liquid;
(2.2) under aseptic condition, with (2.1) coarse filtration liquid input hollow-fibre ultrafiltration device, carry out ultrafiltration, ultrafiltrate input material-compound tank;
(2.3) under agitation, (1.3) molten ethoxylation of joining and sterilizing is made with extra care hickory oil, the superfine ermine oil of ethoxylation, reaches (1.4) active dew of Chinese soft-shelled turtle, GONGBAOSU, aloe liquid, liposome-SOD, Radix Ginseng extractive solution, rutin solution, is added to successively in the material-compound tank of (2.2), stir evenly.
(2.4) pH value with mixed liquor in the vitamin C adjusting material-compound tank is 4.5-4.8;
(2.5) stir down, add the miscible essence of mixed liquor, antiseptic, tween 20 of hyaluronic acid serosity and epidermal growth factor more successively, stir evenly;
(2.6) adding water to total amount is 100 parts (weight), stirs evenly;
(1) (2) each step institute water is sterilized water.
9, preparation as claimed in claim 8 contains the method for the surfactant of snail extract, it is characterized in that described sterilized water is meant that deionized water after the ion exchange resin exchanger resin is handled is again through the water of hollow-fibre ultrafiltration device ultrafiltration.
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| Application Number | Priority Date | Filing Date | Title |
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| CN94106048A CN1112831A (en) | 1994-05-30 | 1994-05-30 | Long lasting multi-function nutritive skin care liquid containing extract of snail and the mfg. method |
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| CN94106048A CN1112831A (en) | 1994-05-30 | 1994-05-30 | Long lasting multi-function nutritive skin care liquid containing extract of snail and the mfg. method |
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| CN103655439A (en) * | 2013-05-24 | 2014-03-26 | 钱臻 | Biologically fermented skin-care lotion and preparation method thereof |
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| CN103655439B (en) * | 2013-05-24 | 2015-09-09 | 钱臻 | A kind of biofermentation surfactant and preparation method thereof |
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| CN104784092B (en) * | 2015-04-02 | 2018-05-04 | 沈阳伊霏霖生物科技有限公司 | A kind of skin repairs nutrient solution immediately |
| CN104784092A (en) * | 2015-04-02 | 2015-07-22 | 沈阳伊霏霖生物科技有限公司 | Nutrient solution for instantly repairing skin |
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| WO2017011982A1 (en) * | 2015-07-20 | 2017-01-26 | 江阴市本特塞缪森生命科学研究院有限公司 | Mussel adhesive protein product and applications thereof in suppression of skin inflammations |
| WO2017011984A1 (en) * | 2015-07-20 | 2017-01-26 | 江阴市本特塞缪森生命科学研究院有限公司 | Applications of mussel adhesive protein product in treatment and prevention of diseases related to melanin |
| US10568938B2 (en) | 2015-07-20 | 2020-02-25 | Jiangyin Bengt I. Samuelsson Institute Of Life Science Co., Ltd. | Mussel adhesive protein product and applications thereof in suppression of skin inflammations |
| US10675327B2 (en) | 2015-07-20 | 2020-06-09 | Jiangyin Bengt I. Samuelsson Institute Of Life Science Co., Ltd. | Applications of mussel adhesive protein product in treatment and prevention of diseases related to melanin |
| US11090360B2 (en) | 2015-07-20 | 2021-08-17 | Jiangyin Bengt I. Samuelsson Institute Of Life Science Co., Ltd. | Applications of mussel adhesive protein product in treatment and prevention of diseases related to melanin |
| US11260111B2 (en) | 2015-07-20 | 2022-03-01 | Jiangyin Bengt I. Samuelsson Institute Of Life Science Co., Ltd. | Mussel adhesive protein product and applications thereof in suppression of skin inflammations |
| US10485848B2 (en) | 2015-08-14 | 2019-11-26 | Jiangyin Bengt I. Samuelsson Institute Of Life Science Co., Ltd. | Mussel adhesive protein product and use thereof for treating mucosal inflammation |
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