CN102525864B - Marine biological functional cosmetic for removing acne - Google Patents
Marine biological functional cosmetic for removing acne Download PDFInfo
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Abstract
The invention discloses marine biological functional cosmetics for removing acne. The marine biological functional cosmetics contain marine shellfish active peptides, algal polysaccharides and pearl powder as major active ingredients, in addition of linoleic acid, allantoin, vitamin A palmitate, vitamin B6 and aloe juice, and have a remarkable and highly-effective anti-acne effect. The invention solves the problems in the prior art that the existing anti-acne cosmetics have serious irritation and possibly causes skin allergy, the Chinese medicinal anti-acne cosmetics possibly causes dark acne scars and have unpleasant odor, and the use of marine shellfish active peptides in anti-acne cosmetics is unknown. The anti-acne functional cosmetics are safe, mild and sustained, and can significantly kill microbes, relieve inflammations, keep oil secretion in balance, promote wound healing, heal scars, remove acne scars and inhibit pigmentation. The anti-acne functional cosmetics are available in various forms such as creams, emulsions, lotions, gels, sprays or facial masks, have remarkable and long-lasting anti-acne effects, prevent acne recurrence after withdrawal, and are suitable for various populations suffering from acnes, scars or acne scars.
Description
Technical field
The invention belongs to cosmetic field, be specifically related to a kind of function cosmetics for removing acne, relate in particular to a kind of marine biological functional cosmetic that is used for removing acne of the preparation take marine organism extract as main active.
Background technology
Comedo has another name called acne, skin sore or acne, is a kind of common chronic pilosebaceous unit diseases associated with inflammation, is apt to occur in the vigorous position of sebum secretion such as face, shirtfront and upper back.With the variation of dietary habit, the sickness rate of comedo rises year by year with the quickening pace of modern life.According to investigations, 80% teenager and adult's face of 50% have comedo in the west, and almost 95% Chinese have comedo in various degree, wherein 55% throughout the year long pox.The comedo course of disease is long, easily recurrence, shows as hoary hair's acne, blackhead or inflammatory pimple more, serious pustule, tuberosity, cyst or the cicatrix of also having.If inflammation is obvious, can causes pain or touch pain, and with seborrhea, even the Pericarpium Citri Reticulatae face can occur.Comedo not only has a strong impact on face appearance, and affects the social and psychological of people, the patient is prone to lose, anxiety, irritability, not self-confident, awkward, depression and the negative emotions such as nervous, thereby has affected quality of life.
At present, on market, the cosmetics for the treatment of comedo have added chemical bactericide, hormone, astringent, antiinflammatory etc. more, though can sterilize at short notice or diminish inflammation, but large to skin irritation, life-time service can increase the skin burden, and easily causes the allergic symptoms such as red swelling of the skin, suppuration or pain, and because pathogen very easily produces drug resistance, comedo can recur very soon, easily forms cicatrix or pigmentation.Antibiotic and hormonal substance are now forbidden by " cosmetics health standard " (version in 2007) because the life-time service side effect is large.The Chinese medicine acne-eliminating cosmetic is slow due to onset, treatment cycle long, niff and color are arranged more, also can stay black or Red Sigil after healing, also is not subjected to the welcome of consumer.Therefore, development a kind of safer, gentle, lastingly and the comprehensive acne-eliminating cosmetic of effect become and enjoyed popular confidence.
The marine bioactivity extract relies on himself good biocompatibility, conclusive moistening water conservation effect and significant sterilization, sun-proof, whitening, promotion collagen protein synthesis and the effects such as wound healing, the reparation of promotion skin barrier function have been subject to scientific research personnel's attention and the favor on beauty treatment circle.The marine bioactivity materials such as collagen peptide, Sargassum polysaccharides, Margarita powder, oligonucleotide, chondroitin sulfate, carotenoid, squalane have been become all kinds of cosmetics by develop, but still belong to blank for the marine biological functional cosmetic of removing acne.In addition, seashells as one of most precious living marine resources, its bioactive peptide also has the effects such as significant slow down aging, radioprotective, promotion wound healing, at present existing patent of invention discloses the seashells anti-oxidation peptide and can be used for cosmetics, but do not relate to actual technique for applying technology and formula, its application in acne-eliminating cosmetic is also not yet mentioned.
Summary of the invention
The object of the invention is to, the skin problems such as easily allergy, Chinese medicine acne-eliminating cosmetic easily stay the dark marking, the smell is awful large for existing removing acne cosmetics zest, be engaged in for a long time marine bioactivity material efficacy study through the inventor and understanding in depth on the basis of comedo formation mechanism, a kind of safe, gentle and lasting marine biological functional cosmetic that is used for removing acne is being provided.This cosmetics removing acne functional component is clear and definite, steady quality, numerous in variety, has no side effect, and can not cause skin allergy, can scar or pigmentation after comedo is cured, and after stopping using, comedo also is difficult for recurrence.
Forming marine biological functional cosmetic main active of the present invention and the mass fraction in cosmetics thereof is: oceanic shellfish active peptide 0.1%-10%, Sargassum polysaccharides 0.1%-10%, Margarita powder 0.2%-15%.The preferred mass mark that forms marine biological functional cosmetic main active of the present invention is: oceanic shellfish active peptide 1%-10%, Sargassum polysaccharides 0.2%-8%, Margarita powder 2%-10%.
For strengthening the effect of removing acne, the active component that forms marine biological functional cosmetic of the present invention also comprises the component that following mass fraction forms: linoleic acid 0.5%-6%, allantoin 0.05%-0.6%, V
ACetylate 0.1%-2%, V
B60.05%-10% and Aloe juice 1%-15%.
In above-mentioned active component, described oceanic shellfish active peptide refers to that the seashells soft body passes through the oceanic shellfish active peptide mixture that makes after protease hydrolyzed, the ultrafiltration of 3000Da ultrafilter membrane, described seashells refers to one or more the combination in Paphia Undulata, Corbiculida, Margarita, scallop, mussel, Concha Ostreae, wherein is preferably Paphia Undulata.Described protease is one or more the combination in bromelain, papain, neutral protease, alkaline protease, pepsin, trypsin, subtilisin.Specifically the preparation method of oceanic shellfish active peptide is as follows: get the edible seashells that meets the relevant marine product Application standard of China, shell and add 2-4 times of volume pure water homogenate 3-5min after internal organs, room temperature adds protease, enzyme concentration is 1000-3000U/g shellfish meat, be 6.5-7.5 at pH, temperature is 40-60 ℃ of enzymolysis 30-90min, boiling water bath enzyme denaturing 5-8min, the centrifugal 10-15min of 5000-8000r/m, supernatant is the ultrafiltration of 3000Da ultrafilter membrane by molecular cut off, and lyophilization makes the oceanic shellfish active peptide powder.
In above-mentioned active component, described Sargassum polysaccharides is one or more the combination in sodium alginate, Porphyra Polysaccharide, Sargassum polysaccharide, Thallus Laminariae polysaccharide, sargassan, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma striatum polysaccharide, Hijiki polysaccharide, commercially available, also can be according to existing method preparation.
In above-mentioned active component, described Margarita powder is one or more the combination in nanometer Margarita powder, water soluble Margarita ultrafine powder, soludie pearl powder, pearl hydrolysate liposome, and is commercially available, also can be according to existing method preparation.
In above-mentioned active component, described Aloe juice is commercially available, also can be according to existing method preparation.
Described linoleic acid, allantoin, V
ACetylate, V
B6Be commercial with the cosmetic base component.
Above-mentioned active substance carries out homogenizing or mixes with the cosmetic base component by common process, namely can be made into cream frost, emulsion, water preparation, gel, spraying or facial film.Cosmetics exquisite quality in the present invention, glossy, good stability, coating is even, spreadability is good, can not cause skin allergy.
Marine biological functional cosmetic in the present invention is carried out SD rat skin acute toxicity, new zealand rabbit skin irritation and the experiment of guinea pig skin allergy, result shows that toxic reaction does not appear in the marine biological functional cosmetic in the present invention, to the intact skin nonirritant, the guinea pig skin allergy without obvious effect, only had the minimal irritation effect to the new zealand rabbit damaged skin.
Zoopery and human body experimental result on probation shows, marine biological functional cosmetic in the present invention can suppress pathogen propagation, reduce inflammation, and can balance skin oil and fat secretion, dissolution angular embolization, decomposition be blocked in keratin in sebaceous gland or pore and dead bark, the reparation of promotion injured skin, have comprehensive acne-removing.After comedo was cured, preventing from scar did not more have pigmentation.The effect of the marine biological functional cosmetic removing acne in the present invention is remarkable and efficient, and after stopping using, comedo is difficult for recurring, and not only can be used for removing acne, also can be used for desalinating the pox seal or smooths cicatrix.
Oceanic shellfish active peptide molecular weight in marine biological functional cosmetic of the present invention is little, good water solubility, can infiltrate rapidly skin surface, removes free radical, to keep the Skin Cell youthful vigor.It can also promote skin corium elastic fibers, collagen protein synthesis and the wound healing that is caused by inflammation, comedo, can significantly reduce tyrosinase activity, thereby check melanin forms, and makes skin become pale, pigmentation can not occur.Also contain abundant free amino acid, vitamin and trace element in the oceanic shellfish active peptide mixture, these compositions all can be repaired the skin injury that is caused by comedo effectively.Serine, glycine, threonine and alanine are Moisture factor natural in horny layer, and methionine and cysteine are keratin important composition compositions, and glycine, proline and alanine are collagen protein important composition compositions.Arginine can promote skin metabolism and the wound healing that is caused by the comedo inflammation.Glutamic acid and ornithine can promote cell proliferation and differentiation, and promote collagen protein to generate.Methionine, histidine, glutamic acid and cysteine can protect skin to form pigmentation because of ultraviolet radiation.V
ECan increase horny layer humidity, horny layer softening, improve the skin smooth degree, protection skin is avoided oxidative damage.Zn is indispensable composition in superoxide dismutase, can promote skin metabolism.Se is the activity of glutathione peroxidase center, can resist ultraviolet and cause pigmentation.
Sargassum polysaccharides in marine biological functional cosmetic of the present invention can form hydrogen bond with hydrone, jointly form gelatinised matrix outside the born of the same parents that contain large quantity of moisture with other polysaccharide components and fibrous proteins in extracellular matrix, also can form thin film at skin surface, to reduce the evaporation of skin surface moisture, make moisture permeate into horny layer from substrate microstructure, induce the further aquation of horny layer, thereby preserve moisture of skin, played good horny layer softening effect.Sargassum polysaccharides can also the dissolution of bacteria adventitia, thereby promotes lysozyme to the destruction of antibacterial (especially gram negative bacteria), has the bacteriostasis of wide spectrum.In addition, Sargassum polysaccharides can promote horn cell and skin flbroblast growth, removing free radical, keep the activity of the biochemical substances such as epidermal growth factor, SOD, effectively prevent the skin injury that ultraviolet and ionizing radiation cause, and can promote renewal and the reparation of injured skin.Sodium alginate used in the present invention, Porphyra Polysaccharide, Sargassum polysaccharide, Thallus Laminariae polysaccharide, sargassan, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma striatum polysaccharide and Hijiki polysaccharide, its moisturizing, antibacterial and promote that the skin repair effect is good and similar also has good collaborative composite and potentiation with oceanic shellfish active peptide.
Margarita powder in marine biological functional cosmetic of the present invention contains the glycine of needed by human, the trace element such as the aminoacid of the promotion such as methionine skin collagen regeneration and Zn, very easily be absorbed by the body, has bactericidal antiphlogistic, toxin expelling, accelerate the injured skin wound healing, dispel pox seal texts, can effectively strengthen skin cell metabolism, dredging pore, make the dust that is blocked in skin pore, oil stain, antibacterial, decortication, the impurity such as dead cell are discharged smoothly, and can promote reepithelialization, effectively repair the damaged skin that is caused by comedo, make skin become moist, pure white moistening.Nanometer Margarita powder used in the present invention, water soluble Margarita ultrafine powder, soludie pearl powder and pearl hydrolysate liposome, its sterilization, antiinflammatory, promotion wound healing, to dispel pox seal effect good and similar, also has good collaborative composite and potentiation with oceanic shellfish active peptide.
The marine bioactivity material that uses in the present invention is preferably to have the effects such as remarkable sterilization, antiinflammatory, promotion wound healing, desalination pox seal also can stablize collaborative composite oceanic shellfish active peptide, Sargassum polysaccharides and Margarita powder from numerous marine bioactivity extracts.After adjust optimizing each component proportion, its removing acne and the effect that suppresses its recurrence have obtained remarkable enhancing.
Linoleic acid in marine biological functional cosmetic of the present invention is the essential fatty acid of follicular epithelium Growth of Cells, the constituent of cell membrane phospholipid, can improve immobilized artificial membrane content, suppress Keratoderma excessive, and the regulation of skin permeability, epidermal barrier function strengthened, reduce moisture loss, make dry skin and sclerosis horny layer rehydrated, recover horny layer softness and elasticity, make skin smooth, soft and moist, high resilience.Linoleic acid belongs to transdermal absorption accelerator, and the energy rapid permeability is protected the skin base cell radical damage to dermal layer of the skin; accelerate cell metabolism; check melanin forms, protection skin corium elastic fiber, and can promote other active component to penetrate into skin.Linoleic acid can also keep optimum membrane structure and function, improves water retention, recovers the skin normal function, improves the aging skin outward appearance, is a kind of good humidizer.In addition, linoleic acid is effectively protecting skin damage also, such as the impact of moisture loss, detergent etc., and help skin from environmental damage and stress recovery.
Allantoin in marine biological functional cosmetic of the present invention can promote epithelial cell growth, affect the quick spheroidizing of epidermis, and when being used for ulcer and suppuration skin, significantly accelerating wound, be a kind of good skin wound healing agent.Allantoin can also keep humidity of skin, make the skin histology of non-pathological state dry, coarse, firmly thick, texture is dark, give birth to the symptoms such as squama, long wrinkle, aging, keratinization obtains moistening and conditioning, allow skin become soft, springiness and gloss, also can prevent chapped skin.In addition, allantoin or a kind of good cutin inorganic agent can not only soften cuticle albumen, and when peeling off the metabolism cutin, given the moisture of intercellular substance abundance, make coarse and be full of cracks skin becomes smooth and plump.Add allantoin in acne-eliminating cosmetic, can not only greatly improve the cutin metabolism, but accelerating wound healing also reduces skin allergy, and moisturizing, skin protection.
V in marine biological functional cosmetic of the present invention
ACetylate and V
ACompare, its stable chemical nature, the difficult decomposition, can participate in by adjusting the gene expression of cell proliferation and differentiation, can activate Skin Cell, enhance metabolism and the Epithelial cell growth, keep cell normal morphology and function, maintenance skin wetness, prevent that mucosa is because of the drying keratinization.It can also improve skin natural cover for defense function, regulation of skin hydration status, promote collagen protein synthesis, and can suppress propionibacterium acnes propagation and reduce air pollutants to the infringement of skin.V
ACetylate can play the effect of regulating smegma by affecting biosynthesis and the lipid metabolism of glycoprotein in mucosa, prevents hair follicle hyperkeratosis and hypertrophy, helps the treatment to comedo.
V in marine biological functional cosmetic of the present invention
B6With skin health, close contacting being arranged, is the part in a lot of enzymes and auxiliary enzymes molecule.V
B6Can promote skin amino acid metabolism, reduction Permeability of Capillary Wall and hyaluronidase activity, reduction metamorphosis and inflammatory reaction, promotion epithelial cell growth, and can reduce smegma, the regulation of skin oil-water balance is to pachylosis, comedo, daylight sunburn, skin pruritus with sunlight is tanned, seborrhea atopic dermatitis disease, general acne, dryness seborrheic dermatitis eczema and exfoliation skin etc. have the significant effect of improving.
Aloe juice in marine biological functional cosmetic of the present invention contains abundant aminoacid, organic acid, polysaccharide and trace element, and these are all the natural Moisture factor of skin.Aloe juice can go deep into corium, epidermis and subcutaneous tissue, in the fatty deposit in removing pore, also helps other active component to penetrate into deep skin.Aloe juice has significant inhibitory action to the antibacterials such as comedo propionibacterium, escherichia coli, bacillus pyocyaneus, streptococcus and staphylococcus aureus and fungus, can not only change thalli morphology and destroy the thalline structure, can also remove the toxic metabolite that discharges when antibacterial infects and the antibacterial endotoxin that rear thalline stays of being killed.Mucoprotein in Aloe juice can balance the skin oil and fat secretion, its antiinflammatory, analgesic activity also can effectively be alleviated the symptoms such as the swelling that caused by comedo, pain, and promote wound healing, improve and eliminate having cicatrix.
Solution of the present invention is based on the inventor to the various influence factors of comedo and mechanism of production, and to the understanding of marine bioactivity material beauty and skin care effect, in conjunction with modern cosmetics and pharmaceutical research achievement, optimize the raw material with removing acne effect from numerous marine bioactivity extracts, and carry out scientific composition, it is given full play to reach separately mutual synergistic function.Oceanic shellfish active peptide can promote elastic fibers and collagen protein synthesis in skin corium, recover skin tension force and elasticity, promote comedo to close up fast, repair existing dark scar or prevent dark scar to form, can also prevent effectively that ultraviolet from damaging comedo and form pigmentation; Sargassum polysaccharides has extremely strong moisture retention, and the energy horny layer softening plays broad-spectrum bactericidal action by its dissolution of bacteria inner membrance, can remove free radical, prevents the skin lipid peroxidating, and the opposing ultraviolet causes damage to skin, and can repair damaging cells; Margarita powder can promote reepithelialization and damage wound healing, sterilization, antiinflammatory, dredging pore, can also reduce postinflammatory pigmentation, promotes the metabolism of skin, dispels the pox seal; Linoleic acid can suppress Keratoderma excessively, strengthen epidermal barrier function, reduce moisture loss, and can the regulation of skin permeability, accelerate the Transdermal absorption of anti-acne active component, thereby improve the anti-acne effect; Allantoin can improve keratin, the dead bark that cutin metabolism, dissolution angular embolization, decomposition are blocked in sebaceous gland and pore, suppress or the dephlogistication symptom, effectively moistening skin, promote wound healing, and minimizing skin allergy; V
ACetylate can effectively regulate smegma, prevents the hair follicle hyperkeratosis, improve skin barrier function, reduce air pollutants encroaches on skin, can also keep skin wetness, promotes epidermal growth, suppress propionibacterium acnes propagation; V
B6Skin can be reduced to the inflammatory reaction of comedo, and epithelial cell growth, minimizing smegma, regulation of skin oil-water balance can be promoted; Aloe juice can effectively suppress the propagation of the antibacterials such as propionibacterium acnes, escherichia coli, bacillus pyocyaneus, streptococcus and staphylococcus aureus and fungus, and can keep fatty deposit in moisture of skin, Bergamot Mint Extract, removal pore, effectively promote other anti-acne active component to penetrate into deep skin, can also antiinflammatory, analgesia, promotion wound healing, and improve or eliminate existing cicatrix.
Compared with prior art, the present invention has following beneficial effect:
1. to select the marine organism extract of pure natural be primary raw material to marine biological functional cosmetic of the present invention, and contained marine bioactivity substance is absorbed by the skin rapidly, can not bring burden to skin, and safety, gentleness, also do not cause skin allergy.
Marine biological functional cosmetic of the present invention from Bergamot Mint Extract, dissolution angular embolization, anti-bacteria propagation, repair pigmentation after dark scar, anti-ultraviolet, antiinflammatory, antiallergic, antioxidation, moisturizing, anti-inflammatory, promote anti-acne active component percutaneous to absorb, promote the aspects such as comedo wound healing, played remarkable and comprehensive anti-acne effect.4 weeks got final product effective removing acne, cicatrix and pigmentation, made skin recover normally fine and smooth soft and smooth, and the rear symptom of stopping using does not recur, its effect safety, remarkable and lasting.
3. marine biological functional cosmetic of the present invention is numerous in variety, all kinds of crowds of the different sexes that the problems such as comedo, pox seal or cicatrix that are applicable to perplex, age, skin quality.
The specific embodiment
Following examples are to further illustrate of the present invention, are not limitations of the present invention.
Embodiment 1:
Get the edible Paphia Undulata that meets the relevant marine product Application standard of China, shell and add 2 times of volume pure water homogenate 4min after internal organs, boil 5min, add papain after being cooled to room temperature, enzyme concentration is 1000U/g shellfish meat, under room temperature after 170w ultrasonic Treatment 8min, pH is 7, temperature is 50 ℃ of enzymolysis 60min, boiling water bath enzyme denaturing 6min, the centrifugal 15min of 8000r/m, supernatant is the ultrafiltration of 3000Da ultrafilter membrane by molecular cut off, makes the Paphia Undulata active peptide powder after lyophilization.
The composition and the weight content thereof that form marine biological functional cosmetic of the present invention are:
A phase: glyceryl stearate 6%, polydimethylsiloxane 0.5%, hard alcohol 2%, caprylic/capric triglyceride 4%, octyl stearate 2%, linoleic acid 0.5%.
B phase: Paphia Undulata bioactive peptide 8%, Porphyra Polysaccharide 0.1%, water soluble Margarita ultrafine powder 0.2%, allantoin 0.5%, V
B62%, Aloe juice 5%, sorbitol 3.25%, HANSHENGJIAO 0.05%, deionized water surplus.
C phase: polyoxyethylene hydrogenated Oleum Ricini 0.3%, phenoxyethanol/Sensiva SC50 0.8%, V
ACetylate 0.1%.
The D phase: sodium hydroxide is regulated pH=5.5.
Technical process: heat respectively the A phase with B to 75 ℃, under stirring condition, with B be added to A mutually in, homogenizing 3min stirs cooling.Under room temperature, each component of C phase is sequentially added in A, B phase mixture.Regulate pH=5.5 with sodium hydroxide, make the marine biological functional cosmetic spraying for removing acne after the homogenizing mixing.
Embodiment 2:
Getting the edible Corbiculida shells and adds 2.5 times of volume pure water homogenate 5min after internal organs, boil 10min, add bromelain and subtilisin (1:1) after being cooled to room temperature, enzyme concentration is 2000U/g shellfish meat, is 6.5 at pH, and temperature is 40 ℃ of enzymolysis 30min, boiling water bath enzyme denaturing 7min, the centrifugal 12min of 6000r/m, supernatant is the ultrafiltration of 3000Da ultrafilter membrane by molecular cut off, makes the Corbiculida active peptide powder after lyophilization.
The composition and the weight content thereof that form marine biological functional cosmetic of the present invention are:
A phase: Corbiculida bioactive peptide 0.5%, Sargassum polysaccharide 0.5%, Thallus Laminariae polysaccharide 0.5%, soludie pearl powder 2%, allantoin 0.1%, V
B60.05%, Aloe juice 15%, deionized water 53.6%.
B phase: carbomer 0.2%.
C phase: deionized water 20%, EDTA-4Na0.05%, Jojoba alcohol, Jojoba oleic acid potassium and butanediol 2%.
D phase: Cremophor RH40 ester 2.5%, linoleic acid 1.5%, V
ACetylate 0.5%.
E phase: propylene glycol, methyl hydroxybenzoate, propyl p-hydroxybenzoate and hydantoin totally 1%.
Technical process: disperse B to A mutually in, Hybrid Heating to 70 ℃-75 ℃.Under stirring, C is added in the mixture of A, B phase.In the time of 45 ℃, D phase and E are added in system mixing.Make the marine biological functional cosmetic water preparation for removing acne.
Embodiment 3:
Getting edible Margarita, scallop (1:1) shells and adds 3 times of volume pure water homogenate 3min after internal organs, add neutral protease and pepsin (1:1), enzyme concentration is 3000U/g shellfish meat, be 7.5 in pH, temperature is enzymolysis 60min under 60 ℃ of conditions, boiling water bath enzyme denaturing 8min, the centrifugal 10min of 7000r/m, the ultrafilter membrane that supernatant is 3000Da by molecular cut off carries out ultrafiltration, makes Margarita and scallop active peptide powder after lyophilization.
The composition and the weight content thereof that form marine biological functional cosmetic of the present invention are:
A phase: stearic acid 3%, glyceryl stearate (reaching) PEG-100 stearic acid 3%, poly-dimethoxysiloxane 1%, linoleic acid 4%.
B phase: water 16%, carbomer 0.1%.
C phase: Margarita and scallop active peptide 10%, sodium alginate 6%, pearl hydrolysate liposome 5%, allantoin 0.05%, V
B66%, Aloe juice 1%, glycerol 4%, triethanolamine 0.6%, deionized water 33.95%.
D phase: polyoxyethylene hydrogenated Oleum Ricini 4.5%, V
ACetylate 1.5%, two imidazolidinyl urea 0.3%.
Technical process: mix the B phase component.Heat respectively the A phase with B to 70 ℃.Under stirring, slowly B is added to A mutually in.Stirring is cooled to 45 ℃, C is added in the mixture of A, B phase, after mixing 10min, adds successively in order the D phase component, and the mixing homogenizing makes the marine biological functional cosmetic emulsion for removing acne.
Embodiment 4:
Get the edible mussel that meets the relevant marine product Application standard of China, shell and add 4 times of volume pure water homogenate 4min after internal organs, add trypsin and alkaline protease (1:2) after being cooled to room temperature, enzyme concentration is 3000U/g shellfish meat, pH is 7, temperature is 50 ℃ of enzymolysis 90min, boiling water bath enzyme denaturing 5min, the centrifugal 15min of 5000r/m, supernatant is the ultrafiltration of 3000Da ultrafilter membrane by molecular cut off, makes the mussel active Gly-His-Lys after lyophilization.
The composition and the weight content thereof that form marine biological functional cosmetic of the present invention are:
A phase: 16/octadecanol 3%, caprylic/capric triglyceride 2%, ethylhexyl palmitate 4%, linoleic acid 6%.
B phase: mussel active peptide 1%, sargassan 3%, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide 3%, Eucheuma gelatinosum polysaccharide 2%, nanometer Margarita powder 10%, allantoin 0.6%, V
B64%, glycerol 2%, carbomer 0.1%, Aloe juice 4%, asiaticoside 0.5%, deionized water 42.3%.
C phase: Cyclomethicone 4%.
D phase: polyoxyethylene hydrogenated Oleum Ricini 6%, V
ACetylate 2%, parabens 0.5%.
Technical process: heat respectively the A phase with B to 80 ℃, under stirring, B is added to A mutually in.Be cooled to 35 ℃, add C phase and D mutually.Stirring is cooled to room temperature, makes the marine biological functional cosmetic cream frost for removing acne.
Embodiment 5:
According to preparing the method for oceanic shellfish active peptide in embodiment 2, enzymolysis makes the oyster active peptides powder.
The composition and the weight content thereof that form marine biological functional cosmetic of the present invention are:
A phase: HANSHENGJIAO 0.4%, acrylic acid (ester) class/C
10-30Alkylol acrylamide acid esters cross linked polymer 0.6%, EDTA-2Na0.1%, glycerol 5%, UVINUL MS 40 0.2%, oyster active peptides 0.1%, Eucheuma striatum polysaccharide 6%, Hijiki polysaccharide 4%, water soluble Margarita ultrafine powder 3%, pearl hydrolysate liposome 5%, allantoin 0.3%, V
B61%, Aloe juice 10%, polyoxyethylene hydrogenated Oleum Ricini 3%, V
ACetylate 1%.
B phase: linoleic acid 1%, ethanol 25%, antiseptic 0.3%, essence 0.1%, butanediol 5%, hydroxyl butyl toluene 0.1%, Cremophor RH40 ester 1%, deionized water 3%.
The C phase: triethanolamine, regulate pH=5-5.3, the deionized water surplus.
Technical process: mix the A phase component, stir.Mix the B phase component, homogenizing adds deionized water, is stirred to transparent.With B be added to A mutually in, regulate pH=5-5.3, adding deionized water to total amount is 100%, makes the marine biological functional cosmetic gel for removing acne.
Embodiment 6:
According to the mode of preparation oceanic shellfish active peptide in embodiment 1, enzymolysis makes Paphia Undulata active peptide powder and mussel active Gly-His-Lys.
By the shared weight percent meter of each raw material, Paphia Undulata bioactive peptide 3%, mussel active peptide 3%, sargassan 0.2%, nanometer Margarita powder 15%, Semen Armeniacae Amarum powder 11%, Mel 5%, linoleic acid 2%, allantoin 0.4%, V
ACetylate 0.8%, V
B610%, Aloe juice 8%, deionized water 40.6%, antiseptic 1%.With Paphia Undulata bioactive peptide, mussel active peptide, sargassan, allantoin, V
B6Be dissolved in deionized water, after it is all dissolved, add nanometer Margarita powder and the Semen Armeniacae Amarum powder of mixing in advance under room temperature, 50r/m stirring and evenly mixing 5min, then add Mel, linoleic acid, V
ACetylate, Aloe juice and antiseptic, stirring and evenly mixing 5min makes the marine biological functional cosmetic facial film for removing acne.
Embodiment 7:
Following various cosmetics are carried out animal experiment:
Cosmetic base: glyceryl stearate 6%, polydimethylsiloxane 0.5%, hard alcohol 2%, caprylic/capric triglyceride 4%, octyl stearate 2%, sorbitol 3.25%, HANSHENGJIAO 0.05%, polyoxyethylene hydrogenated Oleum Ricini 0.3%, phenoxyethanol/Sensiva SC50 0.8%, deionized water 81.1%.
Cosmetics 1(linoleic acid, allantoin, V
ACetylate, V
B6With the total content of Aloe juice be mass fraction 20%):
A: linoleic acid 2%, allantoin 0.1%, V
ACetylate 0.4%, V
B65%, Aloe juice 12.5%, above-mentioned cosmetic base 80%.
B: linoleic acid 0.5%, allantoin 0.6%, V
ACetylate 0.1%, V
B65.5%, Aloe juice 13.3%, above-mentioned cosmetic base 80%.
C: linoleic acid 6%, allantoin 0.05%, V
ACetylate 1%, V
B60.05%, Aloe juice 12.9%, above-mentioned cosmetic base 80%.
D: linoleic acid 1%, allantoin 0.3%, V
ACetylate 2%, V
B610%, Aloe juice 6.7%, above-mentioned cosmetic base 80%.
Cosmetics 2(oceanic shellfish active peptide, Sargassum polysaccharides, Margarita powder, linoleic acid, allantoin, V
ACetylate, V
B6With the total content of Aloe juice be mass fraction 20%, wherein A
1-A
6Difference only be that the source of oceanic shellfish active peptide is different):
A
1: Paphia Undulata bioactive peptide 8%, Porphyra Polysaccharide 0.5%, water soluble Margarita ultrafine powder 2%, linoleic acid 0.5%, allantoin 0.5%, V
ACetylate 0.5%, V
B62%, Aloe juice 6%, above-mentioned cosmetic base 80%.
A
2: Corbiculida bioactive peptide 8%, other same A
1
A
3: active pearl shell peptide 8%, other same A
1
A
4: scallop active peptide 8%, other same A
1
A
5: mussel active peptide 8%, other same A
1
A
6: oyster active peptides 8%, other same A
1
B: Corbiculida bioactive peptide 0.5%, Sargassum polysaccharide 0.5%, Thallus Laminariae polysaccharide 0.5%, soludie pearl powder 2%, linoleic acid 1.5%, allantoin 0.1%, V
ACetylate 0.5%, V
B60.05%, Aloe juice 14.35%, above-mentioned cosmetic base 80%.
C: active pearl shell peptide 2%, scallop active peptide 2%, sodium alginate 2%, pearl hydrolysate liposome 3%, linoleic acid 2%, allantoin 0.05%, V
ACetylate 1.5%, V
B62%, Aloe juice 5.45%, above-mentioned cosmetic base 80%.
D: mussel active peptide 1%, sargassan 3%, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide 3%, Eucheuma gelatinosum polysaccharide 2%, nanometer Margarita powder 3%, linoleic acid 1%, allantoin 0.6%, V
ACetylate 2%, V
B60.4%, Aloe juice 4%, above-mentioned cosmetic base 80%.
E: oyster active peptides 0.1%, Eucheuma striatum polysaccharide 0.5%, Hijiki polysaccharide 0.5%, water soluble Margarita ultrafine powder 0.5%, pearl hydrolysate liposome 2%, linoleic acid 1%, allantoin 0.4%, V
ACetylate 1%, V
B61%, Aloe juice 13%, above-mentioned cosmetic base 80%.
F: Corbiculida bioactive peptide 1%, mussel active peptide 1%, sargassan 2%, nanometer Margarita powder 5%, linoleic acid 2%, allantoin 0.4%, V
ACetylate 0.8%, V
B61%, Aloe juice 6.8%, above-mentioned cosmetic base 80%.
Get 102 of rabbit, smear 1 time/d of dense liquor carbonis detergens at every rabbit ears medial surface syrinx opening part, application area is 3cm * 3cm, each 0.4mL, continuous 14d, make rabbit ear comedo model, and be divided at random 17 groups, be i.e. normal saline group, cosmetic base group, cosmetics 1 group of (a, b, c, d), 2 groups of (A of cosmetics
1, A
2, A
3, A
4, A
5, A
6, B, C, D, E, F), 6 every group.Be coated with normal saline, cosmetic base, cosmetics 1, cosmetics 2 respectively at rabbit ears affected parts, each approximately 0.5mL, 3 times/d, 7d continuously.Day by day observe therapeutic effect, after last coating 24h, get the auricle skin biopsy with the coating place of picking up the ears after 7d, the tissues observed pathological change the results are shown in Table 1-3.
Table 1 is respectively organized comedo histological grade result (only)
| Group | Normal saline | Cosmetic base | Cosmetics 1 | Cosmetics 2 |
| Without comedo | 0 | 0 | 0 | 23 |
| There is a small amount of fine and close keratinization material in infundibulum of hair follicle section | 0 | 0 | 9 | 34 |
| There is moderate keratinization material in infundibulum of hair follicle section, and extends to sebaceous gland | 3 | 4 | 12 | 6 |
| In the hair follicle of expansion, many keratinization materials are arranged, similar to people's comedo | 3 | 2 | 3 | 3 |
| The rabbit sum | 6 | 6 | 24 | 66 |
* " cosmetics 1 " are the summation of a-d group; " cosmetics 2 " are A
1The summation of-F group.
1 group of comedo histological grade result of table 2 cosmetics (only)
| Group | a | b | c | d |
| Without comedo | 0 | 0 | 0 | 0 |
| There is a small amount of fine and close keratinization material in infundibulum of hair follicle section | 3 | 2 | 0 | 4 |
| There is moderate keratinization material in infundibulum of hair follicle section, and extends to sebaceous gland | 2 | 4 | 5 | 1 |
| In the hair follicle of expansion, many keratinization materials are arranged, similar to people's comedo | 1 | 0 | 1 | 1 |
| The rabbit sum | 6 | 6 | 6 | 6 |
2 groups of comedo histological grade results of table 3 cosmetics (only)
| Group | A 1 | A 2 | A 3 | A 4 | A 5 | A 6 | B | C | D | E | F |
| Without comedo | 4 | 2 | 2 | 1 | 2 | 2 | 1 | 3 | 1 | 2 | 3 |
| There is a small amount of fine and close keratinization material in infundibulum of hair follicle section | 2 | 3 | 4 | 3 | 3 | 4 | 4 | 2 | 3 | 3 | 3 |
| There is moderate keratinization material in infundibulum of hair follicle section, and extends to sebaceous gland | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 |
| In the hair follicle of expansion, many keratinization materials are arranged, similar to people's comedo | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
| The rabbit sum | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
After normal saline group and cosmetic base group coating 7d, comedo is without significant change, pachylosis, and it is obvious that hands touches granular sensation, the visible embolus of rabbit ear skin follicle mouth, visible inflammatory cell infiltration around sebaceous gland, and with tuberosity.
After 1 group of coating 12h of cosmetics, comedo is without significant change; 4d hair follicle surrounding skin begins to come off; 6d hair follicle thrust and tuberosity slightly have and come off; The 7d hands touches skin granular sensation, and the visible embolus of rabbit ear skin follicle mouth also has inflammation around sebaceous gland.
After 2 groups of coating 12h of cosmetics, keratinization skin begins to soften, and the hair follicle surrounding skin comes off; 4d hair follicle thrust and tuberosity obviously come off; 5d loses the hair follicle thrust, loses tuberosity, and hands touches skin without granular sensation; The 7d defensive position is touched skin smoothly and the normal skin no significant difference, and the attenuation of rabbit ear skin keratin, approaches normally, and the sebaceous gland follicular orifice is dispersed in lymphocytic infiltration and disappears, and the healing skin cicatrix is not obvious, and non-pigment is calm.
Because the effect of 2 groups of removing acnes of cosmetics significantly is better than 1 group, cosmetics, this explanation oceanic shellfish active peptide, Sargassum polysaccharides, Margarita powder and linoleic acid, allantoin, V
ACetylate, V
B6, Aloe juice has good forward synergism, and its anti-acne effect is significantly strengthened.
A
1The removing acne successful of group is better than A
2-A
6Group, this shows that the removing acne effect of the marine biological functional cosmetic that contains the Paphia Undulata bioactive peptide is better than containing the marine biological functional cosmetic of Corbiculida bioactive peptide, active pearl shell peptide, scallop active peptide, mussel active peptide or oyster active peptides.Therefore, Paphia Undulata is most preferred seashells in the present invention.
Experimental result shows, the marine biological functional cosmetic in the present invention is rapid-action to the treatment of rabbit ear comedo model, medication 4d namely shows positive effect, and 7d skin approaches normal.Marine biological functional cosmetic solubilized keratotic plug, antiinflammatory in this explanation the present invention also promotes wound to heal rapidly, repair cicatrix, reduce pigmentation, has significant anti-acne effect.
Embodiment 8:
Following various cosmetics are carried out zoopery:
Cosmetic base: HANSHENGJIAO 0.4%, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer 0.6%, EDTA-2Na0.1%, glycerol 5%, UVINUL MS 40 0.2%, ethanol 25%, butanediol 5%, polyoxyethylene hydrogenated Oleum Ricini 3%, Cremophor RH40 ester 1%, essence 0.1%, hydroxyl butyl toluene 0.1%, deionized water 59.5%.
The content of cosmetics A(oceanic shellfish active peptide in cosmetics is mass fraction 5%):
A
1: Paphia Undulata bioactive peptide 5%, cosmetic base 95%;
A
2: active pearl shell peptide 4%, scallop active peptide 1%, cosmetic base 95%;
A
3: oyster active peptides 2%, Corbiculida bioactive peptide 3%, cosmetic base 95%.
The content of cosmetics B(Sargassum polysaccharides in cosmetics is mass fraction 5%):
B
1: sodium alginate 5%, cosmetic base 95%;
B
2: Hijiki polysaccharide 5%, cosmetic base 95%;
B
3: Eucheuma striatum polysaccharide 3%, Thallus Laminariae polysaccharide 2%, cosmetic base 95%.
The content of cosmetics C(Margarita powder in cosmetics is mass fraction 5%):
C
1: pearl hydrolysate liposome 5%, cosmetic base 95%;
C
2: water soluble Margarita ultrafine powder 5%, cosmetic base 95%;
C
3: nanometer Margarita powder 5%, cosmetic base 95%.
Cosmetics D(oceanic shellfish active peptide, Sargassum polysaccharides, the total content of Margarita powder in cosmetics are mass fraction 5%):
D
1: Paphia Undulata bioactive peptide 3%, sodium alginate 1%, pearl hydrolysate liposome 1%, cosmetic base 95%;
D
2: active pearl shell peptide 0.5%, scallop active peptide 0.5%, Hijiki polysaccharide 0.5%, water soluble Margarita ultrafine powder 3.5%, cosmetic base 95%;
D
3: oyster active peptides 1%, Corbiculida bioactive peptide 1%, Eucheuma striatum polysaccharide 1%, Thallus Laminariae polysaccharide 1%, nanometer Margarita powder 1%, cosmetic base 95%.
Get 84 of the rabbit of making rabbit ear comedo model, be divided at random 14 groups, namely normal saline group, cosmetic base group, cosmetics A organize (A
1, A
2, A
3), cosmetics B organizes (B
1, B
2, B
3), cosmetics C organizes (C
1, C
2, C
3), cosmetics D organizes (D
1, D
2, D
3), 6 every group.Be coated with normal saline, cosmetic base, cosmetics A, cosmetics B, cosmetics C, cosmetics D respectively at rabbit ears affected parts, each 0.5mL, 3 times/d, 4d continuously.Day by day observe therapeutic effect, after last coating 24h, get with the coating place auricle skin biopsy of picking up the ears, tissues observed pathological change after 4d.By its epidermis thicken and follicular orifice degrees of expansion and keratinization thing what are divided into 4 grades with the pathological change of specimen: " 0 " is for without comedo; "+" is the visible a small amount of fine and close keratinization thing of infundibulum of hair follicle section; " ++ " is infundibulum of hair follicle section visible moderate keratinization thing, and extends to sebaceous gland; " +++" in the hair follicle of expanding, keratinization thing widely being arranged.The results are shown in Table 4.
The impact of table 4 cosmetics on rabbit ear comedo model
Experimental result shows, cosmetics (the cosmetics D group) successful of removing acne that contains oceanic shellfish active peptide, Sargassum polysaccharides and Margarita powder is better than only containing the cosmetics (cosmetics A group) of oceanic shellfish active peptide, only contain the cosmetics (cosmetics B group) of Sargassum polysaccharides, only contain the cosmetics (cosmetics C group) of Margarita powder.This explanation oceanic shellfish active peptide, Sargassum polysaccharides, Margarita powder have good collaborative complex role, can significantly strengthen the removing acne effect and can effectively suppress its recurrence.
Embodiment 9
Cosmetics to embodiment 1-6 preparation carry out human body experiment on probation.Choose totally 30 of light, the facial ordinary comedo volunteers of moderate, man, female half and half; Age 17-35 year, average 26 years old; Suffer from journey 4 week-7 year, average 3.1 years, 2 weeks before smearing cosmetics, do not use glucocorticosteroid hormone, tretinoin and antibiotics, abnormal without hyperlipidemia and hepatic and renal function, forbid excessive drinking, avoid sunburst or ultraviolet excessively to shine.30 volunteers are divided into 6 groups at random, every group of 5 people.
The experimenter is with warm water cleaning pars affecta skin and after drying, smear every night counter sample 1 time, inactive other drug or cosmetics between the operating period, judges after 4 weeks that (the facial film using method prepared of embodiment 6 is warm water cleaning face to curative effect, after being applied to pars affecta skin 10min, facial film cleans with clear water, 1 time every night, totally 4 weeks).Reach the 1st week for the treatment of, 2 weeks, 3 week and 4 weeks before treatment, respectively the facial inflammatory damage sum of volunteer (summation of inflammatory pimple and pustule), non-inflammatory lesions sum (summation of hoary hair's acne and blackhead) are counted the untoward reaction after itemized record are used simultaneously.Criterion: base is healed: therapeutic index 〉=90%; Produce effects: 60%≤therapeutic index＜90%; Progressive: 20%≤therapeutic index＜60%; Invalid: therapeutic index＜20%.Total skin lesion number * 100% before therapeutic index=(the rear total skin lesion number of total skin lesion number-treatment before treatment)/treatment.Effective percentage=(base is number of cases+produce effects number of cases more)/all number of cases * 100%.The effect of each group treatment comedo sees Table 5-7.
Non-inflammatory lesions sum (individual) after table 5 makes and applies some make up
| Follow up a case by regular visits to time point | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 |
| Skin adverse reaction | Nothing | Nothing | Nothing | Nothing | Nothing | Nothing |
| Before treatment | 17.1±7.6 | 18.3±4.2 | 18.9±4.7 | 17.9±6.3 | 21.0±5.3 | 19.1±8.6 |
| 1 week | 14. 7±5.4 | 14.1±5.7 | 15.1±4.2 | 14.5±4.8 | 16.8±5.8 | 16.1±6.8 |
| 2 weeks | 11.1±3.9 | 10.8±3.6 | 11.5±3.9 | 11.3±4.6 | 12.9±4.9 | 12.9±5.1 |
| 3 weeks | 8.2±4.7 | 7.6±5.0 | 7.7±4.1 | 6.9±3.5 | 8.7±4.1 | 9.4±4.3 |
| 4 weeks | 4.6±3.3 | 5.2±4.1 | 4.2±3.9 | 4.4±3.1 | 4.8±3.8 | 6.3±2.9 |
Non-inflammatory skin lesion: hoary hair's acne or blackhead
Inflammatory damage sum (individual) after table 6 makes and applies some make up
| Follow up a case by regular visits to time point | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 |
| Skin adverse reaction | Nothing | Nothing | Nothing | Nothing | Nothing | Nothing |
| Before treatment | 21.5±5.7 | 23.9±6.1 | 20.8±5.3 | 23.6±6.9 | 20.2±7.3 | 24.4±6.6 |
| 1 week | 15.9±5.1 | 18.8±7.2 | 16.2±6.3 | 18.9±6.0 | 16.0±5.8 | 20.0±6.4 |
| 2 weeks | 11.8±4.9 | 13.4±6.8 | 11.7±5.4 | 13.7±5.8 | 11.9±4.5 | 16.2±5.6 |
| 3 weeks | 7.6±3.8 | 8.1±5.5 | 7.3±5.6 | 8.4±5.3 | 7.3±4.2 | 11.9±4.3 |
| 4 weeks | 3.2±2.4 | 3.6±2.3 | 3.8±2.1 | 4.2±3.4 | 5.2±3.6 | 8.2±3.9 |
Cutaneous inflammatory lesion: obviously rubescent or inflammatory pimple and the pustule of infiltration arranged.
Table 7 is the therapeutic effect of cosmetics to comedo after 4 weeks
| Group | Base more | Produce effects | Progressive | Invalid | Total number of cases | Effective percentage (%) |
| Embodiment 1 | 4 | 1 | 0 | 0 | 5 | 100 |
| Embodiment 2 | 4 | 1 | 0 | 0 | 5 | 100 |
| Embodiment 3 | 3 | 2 | 0 | 0 | 5 | 100 |
| Embodiment 4 | 3 | 2 | 0 | 0 | 5 | 100 |
| Embodiment 5 | 2 | 3 | 0 | 0 | 5 | 100 |
| Embodiment 6 | 1 | 3 | 1 | 0 | 5 | 80 |
Marine biological functional cosmetic in use the present invention is after 4 weeks, but removing acne, cicatrix and pigmentation make skin recover normally fine and smooth soft and smooth, and the rear comedo symptom of stopping using does not recur, its acne-removing safety, remarkable and lasting.Marine biological functional cosmetic in this explanation the present invention has comprehensively, significant removing acne effect.
Claims (1)
1. a marine biological functional cosmetic that is used for removing acne, is characterized in that forming the active component that this marine biological functional cosmetic comprises that cubage by weight is following: oceanic shellfish active peptide 0.1%-10%, Sargassum polysaccharides 0.1%-10%, Margarita powder 0.2%-15%, linoleic acid wt0.5%-6%, allantoin wt0.05%-0.6%, V
ACetylate wt0.1%-2%, V
B6Wt0.05%-10% and Aloe juice wt1%-15%.
2. the marine biological functional cosmetic for removing acne as claimed in claim 1 is characterized in that forming the weight content of this marine biological functional cosmetic main active in cosmetics and is: oceanic shellfish active peptide 1%-10%, Sargassum polysaccharides 0.2%-8%, Margarita powder 2%-10%.
3. the marine biological functional cosmetic for removing acne as claimed in claim 1 or 2, is characterized in that described oceanic shellfish active peptide refers to the oceanic shellfish active peptide mixture that makes after the seashells soft body is through protease hydrolyzed, the ultrafiltration of 3000Da ultrafilter membrane; Described protease is one or more the combination in neutral protease, alkaline protease.
4. the marine biological functional cosmetic for removing acne as claimed in claim 1 or 2, is characterized in that described oceanic shellfish active peptide refers to the oceanic shellfish active peptide mixture that makes after the seashells soft body is through protease hydrolyzed, the ultrafiltration of 3000Da ultrafilter membrane; Described protease is one or more the combination in bromelain, papain, pepsin, trypsin, subtilisin.
5. the marine biological functional cosmetic for removing acne as claimed in claim 1 or 2 is characterized in that described seashells refers to one or more the combination in Paphia Undulata, Corbiculida, Margarita, scallop, mussel, Concha Ostreae.
6. the marine biological functional cosmetic for removing acne as claimed in claim 1 or 2, is characterized in that described seashells is Paphia Undulata.
7. the marine biological functional cosmetic for removing acne as claimed in claim 1 or 2 is characterized in that described Sargassum polysaccharides is one or more the combination in sodium alginate, Porphyra Polysaccharide, Sargassum polysaccharide, Thallus Laminariae polysaccharide, sargassan, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma striatum polysaccharide, Hijiki polysaccharide.
8. the marine biological functional cosmetic for removing acne as claimed in claim 1 or 2 is characterized in that described Margarita powder is one or more the combination in nanometer Margarita powder, water soluble Margarita ultrafine powder, pearl hydrolysate liposome.
9. the marine biological functional cosmetic for removing acne as claimed in claim 1 or 2, is characterized in that described marine biological functional cosmetic is cream frost, emulsion, water preparation, gel, spraying or facial film.
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| JP2018510910A (en) * | 2015-03-24 | 2018-04-19 | ザ・ニュージーランド・インスティチュート・フォー・プラント・アンド・フード・リサーチ・リミテッド | Water-soluble mussel extract |
| FR3034780B1 (en) | 2015-04-10 | 2018-10-19 | Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic | PROCESS FOR OBTAINING CULTURE OF CELLS OF RED ALGAE ACROCHAETIUM MONILIFORM, METHOD FOR OBTAINING EXTRACT FROM BIOMASS AND USE THEREOF IN COSMETICS |
| DK201600316A1 (en) * | 2016-05-27 | 2017-12-11 | Tingen Tech Co Ltd | Chinese drugs pharmaceutics for pimple scar elimination and the preparation method thereof |
| CN106619435A (en) * | 2016-10-19 | 2017-05-10 | 刘艺鹏 | Marine shellfish active peptide moisturizer |
| JP6493703B1 (en) | 2017-09-28 | 2019-04-03 | ウシオ電機株式会社 | Sterilization method, sterilizer |
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| CN108553326A (en) * | 2018-04-28 | 2018-09-21 | 浦江县昂宝生物技术有限公司 | Preparation method added with clam active polypeptide moisturizer |
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| CN109771449A (en) * | 2019-02-24 | 2019-05-21 | 温州大学 | A kind of Hijiki polysaccharide and its application with promotion wound healing effect |
| CN110433094A (en) * | 2019-08-27 | 2019-11-12 | 广东锦玛绿色食品科技有限公司 | A kind of cosmetics and preparation method thereof with skin nti-freckle repair function |
| CN111632013B (en) * | 2020-06-09 | 2022-06-28 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition, soothing and repairing powder preparation and preparation method thereof |
| CN111743830A (en) * | 2020-06-19 | 2020-10-09 | 广州天玺生物科技有限公司 | Acne-removing composition and application thereof |
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