CN102525864A - Marine biological functional cosmetic for removing acne - Google Patents
Marine biological functional cosmetic for removing acne Download PDFInfo
- Publication number
- CN102525864A CN102525864A CN2012100018044A CN201210001804A CN102525864A CN 102525864 A CN102525864 A CN 102525864A CN 2012100018044 A CN2012100018044 A CN 2012100018044A CN 201210001804 A CN201210001804 A CN 201210001804A CN 102525864 A CN102525864 A CN 102525864A
- Authority
- CN
- China
- Prior art keywords
- cosmetics
- comedo
- marine organisms
- acne
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses marine biological functional cosmetics for removing acne. The marine biological functional cosmetics contain marine shellfish active peptides, algal polysaccharides and pearl powder as major active ingredients, in addition of linoleic acid, allantoin, vitamin A palmitate, vitamin B6 and aloe juice, and have a remarkable and highly-effective anti-acne effect. The invention solves the problems in the prior art that the existing anti-acne cosmetics have serious irritation and possibly causes skin allergy, the Chinese medicinal anti-acne cosmetics possibly causes dark acne scars and have unpleasant odor, and the use of marine shellfish active peptides in anti-acne cosmetics is unknown. The anti-acne functional cosmetics are safe, mild and sustained, and can significantly kill microbes, relieve inflammations, keep oil secretion in balance, promote wound healing, heal scars, remove acne scars and inhibit pigmentation. The anti-acne functional cosmetics are available in various forms such as creams, emulsions, lotions, gels, sprays or facial masks, have remarkable and long-lasting anti-acne effects, prevent acne recurrence after withdrawal, and are suitable for various populations suffering from acnes, scars or acne scars.
Description
Technical field
The invention belongs to cosmetic field, be specifically related to a kind of function cosmetics that are used to dispel comedo, relating in particular to a kind of is the marine organisms function cosmetics that are used to dispel comedo of main active preparation with the marine organism extract.
Background technology
Comedo has another name called acne, skin sore or acne, is a kind of common chronic pilosebaceous unit diseases associated with inflammation, good sending out in vigorous positions of sebum secretion such as face, shirtfront and last backs.With the variation of dietary habit, the sickness rate of comedo rises year by year with the quickening pace of modern life.According to investigations, 80% teenager and adult's face of 50% all have comedo in the west, and almost 95% Chinese have comedo in various degree, wherein 55% throughout the year long pox.The comedo course of disease is long, be prone to recurrence, shows as hoary hair's acne, blackhead or inflammatory pimple more, serious pustule, tuberosity, cyst or the cicatrix of also having.If inflammation is obvious, then can cause pain or touch painfully, and with seborrhea, even the Pericarpium Citri Reticulatae face can appear.Comedo not only has a strong impact on face appearance, and influences the social and psychological of people, the patient is prone to lose, negative emotions such as anxiety, irritability, not self-confident, awkward, depression and anxiety, thereby has influenced quality of life.
At present, the cosmetics of treatment comedo have added chemical bactericide, hormone, astringent, antiinflammatory etc. more on the market, though antibacterial or diminish inflammation at short notice; But it is big to skin irritation; Life-time service can increase the skin burden, and is prone to cause allergic symptoms such as red swelling of the skin, suppuration or pain, and because pathogen very easily produces drug resistance; Comedo can recur very soon, is prone to form cicatrix or pigmentation.Antibiotic and hormonal substance are forbidden by " cosmetics health standard " (version in 2007) because the life-time service side effect is big at present.The Chinese medicine acne-eliminating cosmetic also can stay the black or the red marking because onset is slow, treatment cycle is long, niff and color are arranged more after the healing, also do not receive the welcome of consumer.Therefore, developing a kind of safer, gentle, lasting and comprehensive effects acne-eliminating cosmetic has become and has enjoyed popular confidence.
The marine bioactivity extract relies on himself good biocompatibility; Conclusive moistening water conservation effect and significant antibacterial, sun-proof, whiten, promote collagen protein synthesis and effects such as wound healing, the reparation of promotion skin barrier function, received scientific research personnel's the attention and the favor on beauty treatment circle.Marine bioactivity materials such as collagen peptide, Sargassum polysaccharides, Margarita powder, oligonucleotide, chondroitin sulfate, carotenoid, squalane successfully have been developed to all kinds of cosmetics, but the marine organisms function cosmetics that are used to dispel comedo still belong to blank.In addition; Seashells as one of most precious living marine resources; Its bioactive peptide also has effects such as significant slow down aging, radioprotective, promotion wound healing; At present existing patent of invention discloses the seashells anti-oxidation peptide and can be used for cosmetics, but does not relate to actual technique for applying technology and prescription, and its application in acne-eliminating cosmetic is also still not mentioned.
Summary of the invention
The objective of the invention is to having the problems such as comedo cosmetics zest is big, skin is prone to allergy, the Chinese medicine acne-eliminating cosmetic is prone to stay the dark marking, the smell is awful of dispeling now; Be engaged in marine bioactivity material efficacy study for a long time through the inventor and understanding in depth on the basis of comedo formation mechanism, a kind of safe, gentle and persistent marine organisms function cosmetics that are used to dispel comedo are being provided.These cosmetics are dispeled clear and definite, the steady quality, numerous in variety of comedo functional component, have no side effect, and can not cause skin allergy, and comedo can not stay cicatrix or pigmentation after curing, and the back comedo of stopping using also is difficult for recurrence.
Forming marine organisms function cosmetics main active of the present invention and the mass fraction in cosmetics thereof is: seashells bioactive peptide 0.1%-10%, Sargassum polysaccharides 0.1%-10%, Margarita powder 0.2%-15%.The preferred mass mark of forming marine organisms function cosmetics main active of the present invention is: seashells bioactive peptide 1%-10%, Sargassum polysaccharides 0.2%-8%, Margarita powder 2%-10%.
Dispel the effect of comedo for enhancing, the active component of forming marine organisms function cosmetics of the present invention also comprises the component that following mass fraction is formed: linoleic acid 0.5%-6%, allantoin 0.05%-0.6%, V
ACetylate 0.1%-2%, V
B60.05%-10% and Aloe juice 1%-15%.
In the above-mentioned active component; Described seashells bioactive peptide is meant the seashells bioactive peptide mixture that makes after the seashells soft body is through protease hydrolyzed, the ultrafiltration of 3000Da ultrafilter membrane; Said seashells is meant one or more the combination in Paphia Undulata, Corbiculida, Margarita, scallop, mussel, the Concha Ostreae, wherein is preferably Paphia Undulata.Said protease is one or more the combination in bromelain, papain, neutral protease, alkaline protease, pepsin, trypsin, the subtilisin.Specifically the method for preparing of seashells bioactive peptide is following: get the edible seashells that meets China's relevant marine product use standard; Shelling adds 2-4 times of volume pure water homogenate 3-5min behind the internal organs, and room temperature adds protease, and enzyme concentration is a 1000-3000U/g shellfish meat; At pH is 6.5-7.5; Temperature is 40-60 ℃ of enzymolysis 30-90min, boiling water bath enzyme denaturing 5-8min, the centrifugal 10-15min of 5000-8000r/m; Supernatant is the ultrafiltration of 3000Da ultrafilter membrane through molecular cut off, and lyophilization makes the seashells active peptide powder.
In the above-mentioned active component; Described Sargassum polysaccharides is one or more the combination in sodium alginate, Porphyra Polysaccharide, Sargassum polysaccharide, Thallus Laminariae polysaccharide, sargassan, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma striatum polysaccharide, the Hijiki polysaccharide; Commercially available, also can be according to existing method preparation.
In the above-mentioned active component, described Margarita powder is one or more the combination in nanometer Margarita powder, water soluble Margarita ultrafine powder, instant Margarita powder, the pearl hydrolysate liposome, and is commercially available, also can be according to existing method preparation.
In the above-mentioned active component, described Aloe juice is commercially available, also can be according to existing method preparation.
Described linoleic acid, allantoin, V
ACetylate, V
B6Be commercial with the cosmetic base component.
Above-mentioned active substance is through common process, carries out homogenizing with the cosmetic base component or mixes, and promptly can be made into cream frost, emulsion, water preparation, gel, spraying or facial film.Cosmetics exquisite quality among the present invention, glossy, good stability, coating is even, spreadability is good, can not cause skin allergy.
Marine organisms function cosmetics among the present invention are carried out SD rat skin acute toxicity, new zealand rabbit skin irritation and the experiment of guinea pig skin allergy; The result shows that toxic reaction does not appear in the marine organisms function cosmetics among the present invention; To the intact skin nonirritant; The guinea pig skin allergy is not had obvious effect, the new zealand rabbit damaged skin is had only the minimal irritation effect.
Zoopery and human body experimental result on probation shows; Marine organisms function cosmetics among the present invention can suppress pathogen propagation, reduce inflammation; And can balancing skin fat secretion, dissolution angular embolization, decomposition be blocked in keratin and dead bark, the reparation of promotion injured skin in sebaceous gland or the pore, have comprehensive acne-removing.After comedo was cured, preventing from scar did not more have pigmentation.The effect that marine organisms function cosmetics among the present invention are dispeled comedo is remarkable and efficient, and the back comedo of stopping using is difficult for recurring, and not only can be used for dispeling comedo, also can be used for desalinating the pox seal or smooths cicatrix.
Little, the good water solubility of seashells bioactive peptide molecular weight in the marine organisms function cosmetics of the present invention can be infiltrated skin surface rapidly, removes free radical, to keep the Skin Cell youthful vigor.It can also promote skin corium elastic fibers, collagen protein synthesis and the wound healing that is caused by inflammation, comedo, can significantly reduce tyrosinase activity, forms thereby suppress melanin, makes skin become pale, pigmentation can not occur.In seashells bioactive peptide mixture, also contain abundant free amino acid, vitamin and trace element, these compositions all can be repaired the skin injury that is caused by comedo effectively.Serine, glycine, threonine and alanine are NMFs natural in the horny layer, and methionine and cysteine are keratin important composition compositions, and glycine, proline and alanine are collagen protein important composition compositions.Arginine can promote skin metabolism and the wound healing that is caused by the comedo inflammation.Glutamic acid and ornithine can promote cell proliferation and differentiation, and promote collagen protein to generate.Methionine, histidine, glutamic acid and cysteine can protect skin to form pigmentation because of ultraviolet radiation.V
ECan increase horny layer humidity, horny layer softening, improve the skin smooth degree, protection skin is avoided oxidative damage.Zn is an indispensable composition in the superoxide dismutase, can promote skin metabolism.Se is the activity of glutathione peroxidase center, can resist ultraviolet and cause pigmentation.
Sargassum polysaccharides in the marine organisms function cosmetics of the present invention can form hydrogen bond with hydrone; In extracellular matrix, form gelatinised matrix outside the born of the same parents that contain large quantity of moisture jointly, also can form thin film, to reduce the skin surface water evaporates at skin surface with other polysaccharide components and fibrous proteins; Make moisture permeate into horny layer from the substrate tissue; Induce the further aquation of horny layer, thereby preserve moisture of skin, played good horny layer softening effect.Sargassum polysaccharides can also the dissolution of bacteria adventitia, thereby promotes the destruction of lysozyme to antibacterial (especially gram negative bacteria), has the broad-spectrum bacteriostasis.In addition; Sargassum polysaccharides can promote horn cell and SF growth, removing free radical, keep the activity of biochemical substances such as epidermal growth factor, SOD; Effectively prevent the skin injury that ultraviolet and ionizing radiation cause, and can promote the renewal and the reparation of injured skin.Sodium alginate used in the present invention, Porphyra Polysaccharide, Sargassum polysaccharide, Thallus Laminariae polysaccharide, sargassan, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma striatum polysaccharide and Hijiki polysaccharide; It preserves moisture, antibacterial and promote that the skin repair effect is good and similar, also have good collaborative composite and potentiation with the seashells bioactive peptide.
Margarita powder in the marine organisms function cosmetics of the present invention contains the glycine, methionine of needed by human etc. and promotes trace element such as regenerated aminoacid of skin collagen and Zn; Very easily be absorbed by the body; Have bactericidal antiphlogistic, toxin expelling, acceleration injured skin wound healing, dispel effect such as pox seal, can effectively strengthen skin cell metabolism, dredging pore, impurity such as the dust that is blocked in the skin pore, oil stain, antibacterial, decortication, dead cell are discharged smoothly; And can promote reepithelialization; Effectively repair the damaged skin that causes by comedo, make skin become moist, pure white moistening.Nanometer Margarita powder used in the present invention, water soluble Margarita ultrafine powder, instant Margarita powder and pearl hydrolysate liposome; Its antibacterial, antiinflammatory, promotion wound healing, to dispel pox seal effect good and similar, also has good collaborative composite and potentiation with the seashells bioactive peptide.
Employed marine bioactivity material is from numerous marine bioactivity extracts, preferably to have effects such as remarkable antibacterial, antiinflammatory, promotion wound healing, desalination pox seal also can stablize collaborative composite seashells bioactive peptide, Sargassum polysaccharides and Margarita powder among the present invention.Adjustment optimize each set of dispense than after, its effect of dispeling comedo and suppressing its recurrence has obtained remarkable enhancing.
Linoleic acid in the marine organisms function cosmetics of the present invention is the essential fatty acid of follicular epithelium cell growth, is the constituent of cell membrane phospholipid, can improve immobilized artificial membrane content; It is excessive to suppress Keratoderma, and regulates percutaneous permeability, strengthens epidermal barrier function; Reduce moisture loss; Make dry skin and the hydration again of sclerosis horny layer, recover horny layer softness and elasticity, make skin smooth, soft and moist, high resilience.Linoleic acid belongs to transdermal absorption accelerator, and the ability rapid permeability is protected the skin base cell radical damage to dermal layer of the skin; Accelerate cell metabolism; Suppress melanin and form, protection skin corium elastic fiber, and can promote other active component to penetrate into skin.Linoleic acid can also keep optimum membrane structure and function, improves water retention, recovers the skin normal function, improves the aging skin outward appearance, is a kind of good humidizer.In addition, linoleic acid is effectively protecting skin damage also, the for example influence of moisture loss, detergent etc., and help skin from environmental damage with stress recovery.
Allantoin in the marine organisms function cosmetics of the present invention can promote epithelial cell growth, influence the quick spheroidizing of epidermis, and when being used for ulcer and suppuration skin, significantly accelerating wound is a kind of advantages of good skin Wound healing agent.Allantoin can also keep humidity of skin; Make the skin histology of non-pathological state dry, coarse, thick firmly, texture is dark, give birth to symptoms such as squama, long wrinkle, aging, keratinization obtains moistening and conditioning, let skin become soft, springiness and gloss, also can prevent chapped skin.In addition, allantoin still is a kind of good cutin inorganic agent, can not only soften cuticle albumen, and when peeling off the metabolism cutin, given intercellular substance competent moisture, make coarsely to become smooth and plump be full of cracks skin.In acne-eliminating cosmetic, adds allantoin, can not only improve the cutin metabolism greatly, but accelerating wound healing also reduces skin allergy, and preserve moisture, skin protection.
V in the marine organisms function cosmetics of the present invention
ACetylate and V
ACompare; Its chemical property is stable, difficult decomposes; Can be through regulating the gene expression of participating in cell proliferation and differentiation; Can activation Skin Cell, enhance metabolism and the growth of epithelial tissue cell, keep cell normal morphology and function, keep skin wet, prevent that mucosa is because of the drying keratinization.It can also improve skin natural cover for defense function, regulates the skin hydration state, promote collagen protein synthesis, and can suppress propionibacterium acnes propagation and reduce the infringement of air pollutants to skin.V
ACetylate can play the effect of regulating smegma through influencing the biosynthesis and the lipid metabolism of glycoprotein in the mucosa, prevents hair follicle hyperkeratosis and hypertrophy, helps the treatment to comedo.
V in the marine organisms function cosmetics of the present invention
B6With skin health close getting in touch being arranged, is the part in a lot of enzymes and the auxiliary enzymes molecule.V
B6Can promote skin amino acid metabolism, reduction capillary wall permeability and hyaluronidase activity, reduction metamorphosis and inflammatory reaction, promotion epithelial cell growth; And can reduce smegma; Regulate skin oil-water balance, to pachylosis, comedo, daylight sunburn, skin pruritus with sunlight is tanned, seborrhea atopic dermatitis disease, general acne, dryness seborrheic dermatitis eczema and exfoliation property skin etc. have the significant effect of improving.
Aloe juice in the marine organisms function cosmetics of the present invention contains rich in amino acid, organic acid, polysaccharide and trace element, and these all are the natural NMFs of skin.Aloe juice can go deep into corium, epidermis and subcutaneous tissue, in the fatty deposit in removing pore, also helps other active component to penetrate into deep skin.Aloe juice has significant inhibitory effect to antibacterials such as comedo propionibacterium, escherichia coli, bacillus pyocyaneus, streptococcus and staphylococcus aureus and fungus; Can not only change thalli morphology and destroy the thalline structure, the endotoxin that thalline stayed after toxic metabolite that discharges in the time of can also removing bacterial infection and antibacterial were killed.Mucoprotein in the Aloe juice can balancing skin fat secretion, its antiinflammatory, analgesic activity also can effectively be alleviated symptoms such as the swelling that caused by comedo, pain, and promote wound healing, improve and also eliminate existing cicatrix.
Solution of the present invention is based on the inventor to various influence factors of comedo and mechanism of production; And to the understanding of marine bioactivity material beauty and skin care effect; In conjunction with modern cosmetics and pharmaceutical research achievement; From numerous marine bioactivity extracts, optimize and have the raw material of dispeling the comedo effect, and carry out scientific composition, it is given full play to reach mutual synergistic function separately.The active Toplink of seashells promotes elastic fibers and collagen protein synthesis in the skin corium; Recover skin tension force and elasticity; Promote comedo to close up fast, repair existing dark scar or prevent dark scar to form, can also prevent effectively that ultraviolet from damaging comedo and form pigmentation; Sargassum polysaccharides has extremely strong moisture retention, and the ability horny layer softening plays broad-spectrum bactericidal action through its dissolution of bacteria inner membrance, can remove free radical, prevents the skin lipid peroxidating, and the opposing ultraviolet causes damage to skin, and can repair damaging cells; Margarita powder can promote reepithelialization and damage wound healing, antibacterial, antiinflammatory, dredging pore, can also reduce postinflammatory pigmentation, promotes the metabolism of skin, dispels the pox seal; Linoleic acid can suppress Keratoderma excessively, strengthen epidermal barrier function, reduce moisture loss, and can regulate percutaneous permeability, accelerate the Transdermal absorption of anti-acne active component, thereby improve the anti-acne effect; Allantoin can improve keratin, the dead bark that cutin metabolism, dissolution angular embolization, decomposition are blocked in sebaceous gland and pore, suppresses or the dephlogistication symptom, can also effective moistening skin, promote wound healing, and reduce skin allergy; V
ACetylate can effectively regulate smegma, prevents the hair follicle hyperkeratosis, improve skin barrier function, reduce air pollutants encroaches on skin, can also keep skin wet, promotes epidermal growth, suppress propionibacterium acnes propagation; V
B6The inflammatory reaction of skin can be reduced, and epithelial cell growth, minimizing smegma, adjusting skin oil-water balance can be promoted comedo; Aloe juice can effectively suppress the propagation of antibacterials such as propionibacterium acnes, escherichia coli, bacillus pyocyaneus, streptococcus and staphylococcus aureus and fungus; And can keep fatty deposit in moisture of skin, Bergamot Mint Extract, the removal pore, effectively promote other anti-acne active component to penetrate into deep skin, can also antiinflammatory, analgesia, promotion wound healing, and improve or eliminate existing cicatrix.
Compared with prior art, the present invention has following beneficial effect:
1. it is primary raw material that marine organisms function cosmetics of the present invention are selected the marine organism extract of pure natural for use, and contained marine bioactivity material can not bring burden to skin rapidly by skin absorbs, and safety, gentleness, does not also cause skin allergy.
2. marine organisms function cosmetics of the present invention from Bergamot Mint Extract, dissolution angular embolization, inhibition bacterial multiplication, repair dark scar, anti-ultraviolet, antiinflammatory, antiallergic, antioxidation, preserve moisture, pigmentation after the anti-inflammatory, promote anti-acne active component percutaneous to absorb, promote aspects such as comedo wound healing, played remarkable and comprehensive anti-acne effect.4 weeks can effectively be dispeled comedo, cicatrix and pigmentation, made the skin recovery normal fine and smooth soft and smooth, and the back symptom of stopping using does not recur, its effect safety, remarkable and lasting.
3. marine organisms function cosmetics of the present invention are numerous in variety, all kinds of crowds of the different sexes that the problems such as comedo, pox seal or cicatrix that are applicable to perplex, age, skin matter.
The specific embodiment
Following examples are to further specify of the present invention, are not limitations of the present invention.
Embodiment 1:
Get the edible Paphia Undulata that meets China's relevant marine product use standard, add 2 times of volume pure water homogenate 4min behind the internal organs that shell, boil 5min; Add papain after being cooled to room temperature, enzyme concentration is a 1000U/g shellfish meat, under the room temperature behind the 170w ultrasonic Treatment 8min; PH is 7; Temperature is 50 ℃ of enzymolysis 60min, boiling water bath enzyme denaturing 6min, the centrifugal 15min of 8000r/m; Supernatant is the ultrafiltration of 3000Da ultrafilter membrane through molecular cut off, makes the Paphia Undulata active peptide powder after the lyophilization.
Composition and the weight content thereof of forming marine organisms function cosmetics of the present invention are:
A phase: glyceryl stearate 6%, polydimethylsiloxane 0.5%, hard alcohol 2%, caprylic/capric triglyceride 4%, octyl stearate 2%, linoleic acid 0.5%.
B phase: Paphia Undulata bioactive peptide 8%, Porphyra Polysaccharide 0.1%, water soluble Margarita ultrafine powder 0.2%, allantoin 0.5%, V
B62%, Aloe juice 5%, sorbitol 3.25%, HANSHENGJIAO 0.05%, deionized water surplus.
C phase: polyoxyethylene hydrogenated Oleum Ricini 0.3%, phenoxyethanol/ethylhexyl glycerol 0.8%, V
ACetylate 0.1%.
The D phase: sodium hydroxide is regulated pH=5.5.
Technical process: heat respectively A mutually with B to 75 ℃, under the stirring condition, with B be added to A mutually in, homogenizing 3min stirs and cools off.Under the room temperature each component of C phase is sequentially added in A, the B phase mixture.Regulate pH=5.5 with sodium hydroxide, make the marine organisms function cosmetic spray that is used to dispel comedo behind the homogenizing mixing.
Embodiment 2:
Get the edible Corbiculida and shell and add 2.5 times of volume pure water homogenate 5min behind the internal organs, boil 10min, add bromelain and subtilisin (1:1) after being cooled to room temperature; Enzyme concentration is a 2000U/g shellfish meat, is 6.5 at pH, and temperature is 40 ℃ of enzymolysis 30min; Boiling water bath enzyme denaturing 7min; The centrifugal 12min of 6000r/m, supernatant is the ultrafiltration of 3000Da ultrafilter membrane through molecular cut off, makes the Corbiculida active peptide powder after the lyophilization.
Composition and the weight content thereof of forming marine organisms function cosmetics of the present invention are:
A phase: Corbiculida bioactive peptide 0.5%, Sargassum polysaccharide 0.5%, Thallus Laminariae polysaccharide 0.5%, instant Margarita powder 2%, allantoin 0.1%, V
B60.05%, Aloe juice 15%, deionized water 53.6%.
B phase: carbomer 0.2%.
C phase: deionized water 20%, EDTA-4Na0.05%, Jojoba alcohol, Jojoba oleic acid potassium and butanediol 2%.
D phase: PEG-40 hydrogenated castor grease 2.5%, linoleic acid 1.5%, V
ACetylate 0.5%.
E phase: propylene glycol, methyl hydroxybenzoate, propyl p-hydroxybenzoate and hydantoin totally 1%.
Technical process: disperse B to A mutually in, Hybrid Heating to 70 ℃-75 ℃.Stir down, C is added in the mixture of A, B phase.In the time of 45 ℃, D phase and E are added in the system mixing.Make the marine organisms function cosmetics water preparation that is used to dispel comedo.
Embodiment 3:
Get edible Margarita, scallop (1:1) and shell and add 3 times of volume pure water homogenate 3min behind the internal organs, add neutral protease and pepsin (1:1), enzyme concentration is a 3000U/g shellfish meat; In pH is 7.5; Temperature is enzymolysis 60min under 60 ℃ of conditions, boiling water bath enzyme denaturing 8min, the centrifugal 10min of 7000r/m; Supernatant is that the ultrafilter membrane of 3000Da carries out ultrafiltration through molecular cut off, makes Margarita and scallop active peptide powder after the lyophilization.
Composition and the weight content thereof of forming marine organisms function cosmetics of the present invention are:
A phase: stearic acid 3%, glyceryl stearate (reaching) PEG-100 stearic acid 3%, gather dimethoxysiloxane 1%, linoleic acid 4%.
B phase: water 16%, carbomer 0.1%.
C phase: Margarita and scallop active peptide 10%, sodium alginate 6%, pearl hydrolysate liposome 5%, allantoin 0.05%, V
B66%, Aloe juice 1%, glycerol 4%, triethanolamine 0.6%, deionized water 33.95%.
D phase: polyoxyethylene hydrogenated Oleum Ricini 4.5%, V
ACetylate 1.5%, two imidazolidinyl urea 0.3%.
Technical process: mix the B phase component.Heat respectively A mutually with B to 70 ℃.Stir down, slowly with B be added to A mutually in.Stirring is cooled to 45 ℃, C is added in the mixture of A, B phase, mix 10min after, add the D phase component in order successively, mix homogenizing and make the marine organisms function cosmetic emulsion that is used to dispel comedo.
Embodiment 4:
Get and meet the edible mussel that the relevant marine product of China uses standard, add 4 times of volume pure water homogenate 4min behind the internal organs that shell, add trypsin and alkaline protease (1:2) after being cooled to room temperature; Enzyme concentration is a 3000U/g shellfish meat; PH is 7, temperature is 50 ℃ of enzymolysis 90min, boiling water bath enzyme denaturing 5min, the centrifugal 15min of 5000r/m; Supernatant is the ultrafiltration of 3000Da ultrafilter membrane through molecular cut off, makes mussel active peptide powder after the lyophilization.
Composition and the weight content thereof of forming marine organisms function cosmetics of the present invention are:
A phase: 16/octadecanol 3%, caprylic/capric triglyceride 2%, ethylhexyl palmitate 4%, linoleic acid 6%.
B phase: mussel active peptide 1%, sargassan 3%, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide 3%, Eucheuma gelatinosum polysaccharide 2%, nanometer Margarita powder 10%, allantoin 0.6%, V
B64%, glycerol 2%, carbomer 0.1%, Aloe juice 4%, asiaticoside 0.5%, deionized water 42.3%.
C phase: Cyclomethicone 4%.
D phase: polyoxyethylene hydrogenated Oleum Ricini 6%, V
ACetylate 2%, parabens 0.5%.
Technical process: heat respectively A mutually with B to 80 ℃, stir time with B be added to A mutually in.Be cooled to 35 ℃, add C mutually with D mutually.Stirring is cooled to room temperature, makes the marine organisms function cosmetics cream frost that is used to dispel comedo.
Embodiment 5:
According to the method for preparing the seashells bioactive peptide in the embodiment 2, enzymolysis makes the oyster active peptides powder.
Composition and the weight content thereof of forming marine organisms function cosmetics of the present invention are:
A phase: HANSHENGJIAO 0.4%, acrylic acid (ester) class/C
10-30Alkylol acrylamide acid esters cross linked polymer 0.6%, EDTA-2Na0.1%, glycerol 5%, benzophenone-4 0.2%, oyster active peptides 0.1%, Eucheuma striatum polysaccharide 6%, Hijiki polysaccharide 4%, water soluble Margarita ultrafine powder 3%, pearl hydrolysate liposome 5%, allantoin 0.3%, V
B61%, Aloe juice 10%, polyoxyethylene hydrogenated Oleum Ricini 3%, V
ACetylate 1%.
B phase: linoleic acid 1%, ethanol 25%, antiseptic 0.3%, essence 0.1%, butanediol 5%, hydroxyl butyl toluene 0.1%, PEG-40 hydrogenated castor grease 1%, deionized water 3%.
The C phase: triethanolamine, regulate pH=5-5.3, the deionized water surplus.
Technical process: mix the A phase component, stir.Mix the B phase component, homogenizing adds deionized water, is stirred to transparent.With B be added to A mutually in, regulate pH=5-5.3, adding deionized water to total amount is 100%, makes the marine organisms function cosmetic gel that is used to dispel comedo.
Embodiment 6:
According to the mode of preparation seashells bioactive peptide in the embodiment 1, enzymolysis makes Paphia Undulata active peptide powder and mussel active peptide powder.
By the shared weight percent meter of each raw material, Paphia Undulata bioactive peptide 3%, mussel active peptide 3%, sargassan 0.2%, nanometer Margarita powder 15%, Semen Armeniacae Amarum powder 11%, Mel 5%, linoleic acid 2%, allantoin 0.4%, V
ACetylate 0.8%, V
B610%, Aloe juice 8%, deionized water 40.6%, antiseptic 1%.With Paphia Undulata bioactive peptide, mussel active peptide, sargassan, allantoin, V
B6Be dissolved in the deionized water, make it all after the dissolving, room temperature adds the nanometer Margarita powder and the Semen Armeniacae Amarum powder of mixing in advance down, and 50r/m stirring and evenly mixing 5min adds Mel, linoleic acid, V again
ACetylate, Aloe juice and antiseptic, stirring and evenly mixing 5min makes the marine organisms function cosmetic mask that is used to dispel comedo.
Embodiment 7:
Following various cosmetics are carried out animal experiment:
Cosmetic base: glyceryl stearate 6%, polydimethylsiloxane 0.5%, hard alcohol 2%, caprylic/capric triglyceride 4%, octyl stearate 2%, sorbitol 3.25%, HANSHENGJIAO 0.05%, polyoxyethylene hydrogenated Oleum Ricini 0.3%, phenoxyethanol/ethylhexyl glycerol 0.8%, deionized water 81.1%.
Cosmetics 1 (linoleic acid, allantoin, V
ACetylate, V
B6With the total content of Aloe juice be mass fraction 20%):
A: linoleic acid 2%, allantoin 0.1%, V
ACetylate 0.4%, V
B65%, Aloe juice 12.5%, above-mentioned cosmetic base 80%.
B: linoleic acid 0.5%, allantoin 0.6%, V
ACetylate 0.1%, V
B65.5%, Aloe juice 13.3%, above-mentioned cosmetic base 80%.
C: linoleic acid 6%, allantoin 0.05%, V
ACetylate 1%, V
B60.05%, Aloe juice 12.9%, above-mentioned cosmetic base 80%.
D: linoleic acid 1%, allantoin 0.3%, V
ACetylate 2%, V
B610%, Aloe juice 6.7%, above-mentioned cosmetic base 80%.
Cosmetics 2 (seashells bioactive peptide, Sargassum polysaccharides, Margarita powder, linoleic acid, allantoin, V
ACetylate, V
B6With the total content of Aloe juice be mass fraction 20%, wherein A
1-A
6Difference only be that the source of seashells bioactive peptide is different):
A
1: Paphia Undulata bioactive peptide 8%, Porphyra Polysaccharide 0.5%, water soluble Margarita ultrafine powder 2%, linoleic acid 0.5%, allantoin 0.5%, V
ACetylate 0.5%, V
B62%, Aloe juice 6%, above-mentioned cosmetic base 80%.
A
2: Corbiculida bioactive peptide 8%, other same A
1
A
3: active pearl shell peptide 8%, other same A
1
A
4: scallop active peptide 8%, other same A
1
A
5: mussel active peptide 8%, other same A
1
A
6: oyster active peptides 8%, other same A
1
B: Corbiculida bioactive peptide 0.5%, Sargassum polysaccharide 0.5%, Thallus Laminariae polysaccharide 0.5%, instant Margarita powder 2%, linoleic acid 1.5%, allantoin 0.1%, V
ACetylate 0.5%, V
B60.05%, Aloe juice 14.35%, above-mentioned cosmetic base 80%.
C: active pearl shell peptide 2%, scallop active peptide 2%, sodium alginate 2%, pearl hydrolysate liposome 3%, linoleic acid 2%, allantoin 0.05%, V
ACetylate 1.5%, V
B62%, Aloe juice 5.45%, above-mentioned cosmetic base 80%.
D: mussel active peptide 1%, sargassan 3%, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide 3%, Eucheuma gelatinosum polysaccharide 2%, nanometer Margarita powder 3%, linoleic acid 1%, allantoin 0.6%, V
ACetylate 2%, V
B60.4%, Aloe juice 4%, above-mentioned cosmetic base 80%.
E: oyster active peptides 0.1%, Eucheuma striatum polysaccharide 0.5%, Hijiki polysaccharide 0.5%, water soluble Margarita ultrafine powder 0.5%, pearl hydrolysate liposome 2%, linoleic acid 1%, allantoin 0.4%, V
ACetylate 1%, V
B61%, Aloe juice 13%, above-mentioned cosmetic base 80%.
F: Corbiculida bioactive peptide 1%, mussel active peptide 1%, sargassan 2%, nanometer Margarita powder 5%, linoleic acid 2%, allantoin 0.4%, V
ACetylate 0.8%, V
B61%, Aloe juice 6.8%, above-mentioned cosmetic base 80%.
Get 102 of rabbit; Smear 1 time/d of dense liquor carbonis detergens at every rabbit ears medial surface syrinx opening part, application area is 3cm * 3cm, each 0.4mL; Continuous 14d; Process rabbit ear comedo model, and be divided into 17 groups at random, be i.e. normal saline group, cosmetic base group, cosmetics 1 group of (a, b, c, d), 2 groups of (A of cosmetics
1, A
2, A
3, A
4, A
5, A
6, B, C, D, E, F), 6 every group.Be coated with normal saline, cosmetic base, cosmetics 1, cosmetics 2 about at every turn 0.5mL, 3 times/d, continuous 7d respectively at rabbit ears affected part.Day by day observe therapeutic effect, behind last coating 24h, get auricle skin biopsy behind the 7d with the coating place of picking up the ears, the tissues observed pathological change, the result sees table 1-3.
Table 1 is respectively organized comedo histological grade result (only)
| Group | Normal saline | Cosmetic base | Cosmetics 1 | Cosmetics 2 |
| No comedo | 0 | 0 | 0 | 23 |
| There is a small amount of fine and close keratinization material in infundibulum of hair follicle portion | 0 | 0 | 9 | 34 |
| There is moderate keratinization material in infundibulum of hair follicle portion, and extends to sebaceous gland | 3 | 4 | 12 | 6 |
| In the hair follicle of expansion many keratinization materials are arranged, similar with people's comedo | 3 | 2 | 3 | 3 |
| The rabbit sum | 6 | 6 | 24 | 66 |
* " cosmetics 1 " are the summation of a-d group; " cosmetics 2 " are A
1The summation of-F group.
1 group of comedo histological grade of table 2 cosmetics result (only)
| Group | a | b | c | d |
| No comedo | 0 | 0 | 0 | 0 |
| There is a small amount of fine and close keratinization material in infundibulum of hair follicle portion | 3 | 2 | 0 | 4 |
| There is moderate keratinization material in infundibulum of hair follicle portion, and extends to sebaceous gland | 2 | 4 | 5 | 1 |
| In the hair follicle of expansion many keratinization materials are arranged, similar with people's comedo | 1 | 0 | 1 | 1 |
| The rabbit sum | 6 | 6 | 6 | 6 |
2 groups of comedo histological grades of table 3 cosmetics result (only)
| Group | A 1 | A 2 | A 3 | A 4 | A 5 | A 6 | B | C | D | E | F |
| No comedo | 4 | 2 | 2 | 1 | 2 | 2 | 1 | 3 | 1 | 2 | 3 |
| There is a small amount of fine and close keratinization material in infundibulum of hair follicle portion | 2 | 3 | 4 | 3 | 3 | 4 | 4 | 2 | 3 | 3 | 3 |
| There is moderate keratinization material in infundibulum of hair follicle portion, and extends to sebaceous gland | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 |
| In the hair follicle of expansion many keratinization materials are arranged, similar with people's comedo | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
| The rabbit sum | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
Behind normal saline group and the cosmetic base group coating 7d, comedo does not have significant change, pachylosis, and it is obvious that hands touches granular sensation, the visible embolus of rabbit ear skin follicle mouth, visible inflammatory cell infiltration around the sebaceous gland, and with tuberosity.
Behind 1 group of coating 12h of cosmetics, comedo does not have significant change; 4d hair follicle surrounding skin begins to come off; 6d hair follicle thrust and tuberosity have slightly and come off; The 7d hands touches skin has granular sensation, and the visible embolus of rabbit ear skin follicle mouth also has inflammation around the sebaceous gland.
Behind 2 groups of coating 12h of cosmetics, keratinization skin begins to soften, and the hair follicle surrounding skin comes off; 4d hair follicle thrust and tuberosity obviously come off; 5d loses the hair follicle thrust, loses tuberosity, and hands touches skin does not have granular sensation; The 7d defensive position is touched the level and smooth and normal skin no significant difference of skin, and the attenuation of rabbit ear skin keratin, and near normal, the sebaceous gland follicular orifice is dispersed in lymphocytic infiltration and disappears, and the healing skin cicatrix is not obvious, and non-pigment is calm.
Because 2 groups of effects of dispeling comedo of cosmetics significantly are superior to 1 group in cosmetics, this explanation seashells bioactive peptide, Sargassum polysaccharides, Margarita powder and linoleic acid, allantoin, V
ACetylate, V
B6, Aloe juice has good forward synergism, and its anti-acne effect is significantly strengthened.
A
1The comedo effect of dispeling of group obviously is superior to A
2-A
6Group, this shows the marine organisms function cosmetics that the comedo effect is superior to containing Corbiculida bioactive peptide, active pearl shell peptide, scallop active peptide, mussel active peptide or oyster active peptides of dispeling of the marine organisms function cosmetics that contain the Paphia Undulata bioactive peptide.Therefore, Paphia Undulata is a most preferred seashells among the present invention.
Experimental result shows that the marine organisms function cosmetics among the present invention are rapid-action to the treatment of rabbit ear comedo model, medication 4d promptly shows positive effect, and 7d skin is near normal.Marine organisms function cosmetics solubilized keratotic plug, antiinflammatory among this explanation the present invention also promotes wound to heal, repair cicatrix rapidly, reduce pigmentation, has significant anti-acne effect.
Embodiment 8:
Following various cosmetics are carried out zoopery:
Cosmetic base: HANSHENGJIAO 0.4%, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer 0.6%, EDTA-2Na0.1%, glycerol 5%, benzophenone-4 0.2%, ethanol 25%, butanediol 5%, polyoxyethylene hydrogenated Oleum Ricini 3%, PEG-40 hydrogenated castor grease 1%, essence 0.1%, hydroxyl butyl toluene 0.1%, deionized water 59.5%.
Cosmetics A (content of seashells bioactive peptide in cosmetics is mass fraction 5%):
A
1: Paphia Undulata bioactive peptide 5%, cosmetic base 95%;
A
2: active pearl shell peptide 4%, scallop active peptide 1%, cosmetic base 95%;
A
3: oyster active peptides 2%, Corbiculida bioactive peptide 3%, cosmetic base 95%.
Cosmetics B (content of Sargassum polysaccharides in cosmetics is mass fraction 5%):
B
1: sodium alginate 5%, cosmetic base 95%;
B
2: Hijiki polysaccharide 5%, cosmetic base 95%;
B
3: Eucheuma striatum polysaccharide 3%, Thallus Laminariae polysaccharide 2%, cosmetic base 95%.
Cosmetics C (content of Margarita powder in cosmetics is mass fraction 5%):
C
1: pearl hydrolysate liposome 5%, cosmetic base 95%;
C
2: water soluble Margarita ultrafine powder 5%, cosmetic base 95%;
C
3: nanometer Margarita powder 5%, cosmetic base 95%.
Cosmetics D (seashells bioactive peptide, Sargassum polysaccharides, the Margarita powder total content in cosmetics is a mass fraction 5%):
D
1: Paphia Undulata bioactive peptide 3%, sodium alginate 1%, pearl hydrolysate liposome 1%, cosmetic base 95%;
D
2: active pearl shell peptide 0.5%, scallop active peptide 0.5%, Hijiki polysaccharide 0.5%, water soluble Margarita ultrafine powder 3.5%, cosmetic base 95%;
D
3: oyster active peptides 1%, Corbiculida bioactive peptide 1%, Eucheuma striatum polysaccharide 1%, Thallus Laminariae polysaccharide 1%, nanometer Margarita powder 1%, cosmetic base 95%.
Get 84 of the rabbit of processing rabbit ear comedo model, be divided into 14 groups at random, promptly normal saline group, cosmetic base group, cosmetics A organize (A
1, A
2, A
3), cosmetics B organizes (B
1, B
2, B
3), cosmetics C organizes (C
1, C
2, C
3), cosmetics D organizes (D
1, D
2, D
3), 6 every group.Be coated with normal saline, cosmetic base, cosmetics A, cosmetics B, cosmetics C, cosmetics D each 0.5mL, 3 times/d, continuous 4d respectively at rabbit ears affected part.Day by day observe therapeutic effect, behind last coating 24h, get behind the 4d with picking up the ears coating place auricle skin biopsy, the tissues observed pathological change.By its epidermis thicken and follicular orifice degrees of expansion and keratinization thing what are divided into 4 grades with the pathological change of BIAO and BEN: " 0 " is no comedo; "+" is the visible a small amount of fine and close keratinization thing of infundibulum of hair follicle portion; " ++ " is the visible moderate keratinization thing of infundibulum of hair follicle portion, and extends to sebaceous gland; " +++" in the hair follicle of expanding keratinization thing widely being arranged.The result sees table 4.
Table 4 cosmetics are to the influence of rabbit ear comedo model
Experimental result shows, the effect that the cosmetics (cosmetics D group) that contain seashells bioactive peptide, Sargassum polysaccharides and Margarita powder are dispeled comedo obviously be superior to only containing the cosmetics (cosmetics A group) of seashells bioactive peptide, only contain the cosmetics (cosmetics B group) of Sargassum polysaccharides, only contain the cosmetics (cosmetics C group) of Margarita powder.This explanation seashells bioactive peptide, Sargassum polysaccharides, Margarita powder have good collaborative complex role, can significantly strengthen and dispel the comedo effect and can effectively suppress its recurrence.
Embodiment 9
Cosmetics to embodiment 1-6 preparation carry out human body experiment on probation.Choose totally 30 of light, the facial ordinary comedo volunteers of moderate, man, woman half and half; Age 17-35 year, average 26 years old; Suffer from journey 4 week-7 year, average 3.1 years, 2 weeks before smearing cosmetics, do not use glucocorticosteroid hormone, tretinoin and antibiotics, no hyperlipidemia and hepatic and renal function are unusual, forbid indulging in excessive drinking, and avoid sunburst or ultraviolet excessively to shine.30 volunteers are divided into 6 groups at random, every group 5 people.
The experimenter is with warm water cleaning pars affecta skin and after drying; Smear counter sample every night 1 time; Stop using between the operating period other drug or cosmetics, 4 week the back judge curative effects (the facial film method for using of embodiment 6 preparations is: warm water cleaning face, clean with clear water after facial film is applied to pars affecta skin 10min; 1 time every night, totally 4 weeks).Before treatment, reach the 1st week of treatment, 2 weeks, 3 week and 4 weeks; Respectively the facial inflammatory damage sum of volunteer (summation of inflammatory pimple and pustule), non-inflammatory lesions sum (summation of hoary hair's acne and blackhead) are counted the untoward reaction after itemized record are used simultaneously.Criterion: base is healed: therapeutic index>=90%; Produce effects: 60%≤therapeutic index＜90%; Progressive: 20%≤therapeutic index＜60%; Invalid: therapeutic index＜20%.Total skin lesion number * 100% before therapeutic index=(total skin lesion number before the treatment-total skin lesion number in treatment back)/treatment.Effective percentage=(base heal routine number+produce effects example number)/whole routine numbers * 100%.The effect of each group treatment whelk sees Table 5-7.
Non-inflammatory lesions sum (individual) after table 5 makes and applies some make up
| Follow up a case by regular visits to time point | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 |
| Skin adverse reaction | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have |
| Before the treatment | 17.1±7.6 | 18.3±4.2 | 18.9±4.7 | 17.9±6.3 | 21.0±5.3 | 19.1±8.6 |
| 1 week | 14. 7±5.4 | 14.1±5.7 | 15.1±4.2 | 14.5±4.8 | 16.8±5.8 | 16.1±6.8 |
| 2 weeks | 11.1±3.9 | 10.8±3.6 | 11.5±3.9 | 11.3±4.6 | 12.9±4.9 | 12.9±5.1 |
| 3 weeks | 8.2±4.7 | 7.6±5.0 | 7.7±4.1 | 6.9±3.5 | 8.7±4.1 | 9.4±4.3 |
| 4 weeks | 4.6±3.3 | 5.2±4.1 | 4.2±3.9 | 4.4±3.1 | 4.8±3.8 | 6.3±2.9 |
Non-inflammatory skin lesion: hoary hair's acne or blackhead
Inflammatory damage sum (individual) after table 6 makes and applies some make up
| Follow up a case by regular visits to time point | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 |
| Skin adverse reaction | Do not have | Do not have | Do not have | Do not have | Do not have | Do not have |
| Before the treatment | 21.5±5.7 | 23.9±6.1 | 20.8±5.3 | 23.6±6.9 | 20.2±7.3 | 24.4±6.6 |
| 1 week | 15.9±5.1 | 18.8±7.2 | 16.2±6.3 | 18.9±6.0 | 16.0±5.8 | 20.0±6.4 |
| 2 weeks | 11.8±4.9 | 13.4±6.8 | 11.7±5.4 | 13.7±5.8 | 11.9±4.5 | 16.2±5.6 |
| 3 weeks | 7.6±3.8 | 8.1±5.5 | 7.3±5.6 | 8.4±5.3 | 7.3±4.2 | 11.9±4.3 |
| 4 weeks | 3.2±2.4 | 3.6±2.3 | 3.8±2.1 | 4.2±3.4 | 5.2±3.6 | 8.2±3.9 |
Cutaneous inflammatory lesion: obviously rubescent or the inflammatory pimple and the pustule of infiltration arranged.
Table 74 all backs cosmetics are to the therapeutic effect of comedo
| Group | Base more | Produce effects | Progressive | Invalid | Total routine number | Effective percentage (%) |
| Embodiment 1 | 4 | 1 | 0 | 0 | 5 | 100 |
| Embodiment 2 | 4 | 1 | 0 | 0 | 5 | 100 |
| Embodiment 3 | 3 | 2 | 0 | 0 | 5 | 100 |
| Embodiment 4 | 3 | 2 | 0 | 0 | 5 | 100 |
| Embodiment 5 | 2 | 3 | 0 | 0 | 5 | 100 |
| Embodiment 6 | 1 | 3 | 1 | 0 | 5 | 80 |
After using 4 weeks of marine organisms function cosmetics among the present invention, can dispel comedo, cicatrix and pigmentation, make the skin recovery normal fine and smooth soft and smooth, the back comedo symptom of stopping using does not recur, its acne-removing safety, remarkable and lasting.Marine organisms function cosmetics among this explanation the present invention have comprehensively, dispel significantly the comedo effect.
Claims (10)
1. marine organisms function cosmetics that are used to dispel comedo is characterized in that the active component of forming these marine organisms function cosmetics comprises seashells bioactive peptide, Sargassum polysaccharides and Margarita powder.
2. the marine organisms function cosmetics that are used to dispel comedo as claimed in claim 1 is characterized in that forming the weight content of this marine organisms function cosmetics main active in cosmetics and are: seashells bioactive peptide 0.1%-10%, Sargassum polysaccharides 0.1%-10%, Margarita powder 0.2%-15%.
3. the marine organisms function cosmetics that are used to dispel comedo as claimed in claim 1 is characterized in that forming the weight content of this marine organisms function cosmetics main active in cosmetics and are: seashells bioactive peptide 1%-10%, Sargassum polysaccharides 0.2%-8%, Margarita powder 2%-10%.
4. the marine organisms function cosmetics that are used to dispel comedo as claimed in claim 1 is characterized in that the active component of forming these marine organisms function cosmetics also comprises linoleic acid wt0.5%-6%, allantoin wt0.05%-0.6%, V
ACetylate wt0.1%-2%, V
B6Wt0.05%-10%, Aloe juice wt1%-15%.
5. like claim 1,2, the described marine organisms function cosmetics that are used to dispel comedo of 3 or 4 arbitrary claim, it is characterized in that said seashells bioactive peptide is meant the seashells bioactive peptide mixture that makes after the seashells soft body is through protease hydrolyzed, the ultrafiltration of 3000Da ultrafilter membrane; Said protease is one or more the combination in bromelain, papain, neutral protease, alkaline protease, pepsin, trypsin, the subtilisin.
6. like claim 1,2, the described marine organisms function cosmetics that are used to dispel comedo of 3 or 4 arbitrary claim, it is characterized in that said seashells is meant one or more the combination in Paphia Undulata, Corbiculida, Margarita, scallop, mussel, the Concha Ostreae.
7. like claim 1,2, the described marine organisms function cosmetics that are used to dispel comedo of 3 or 4 arbitrary claim, it is characterized in that said seashells is a Paphia Undulata.
8. like claim 1,2, the described marine organisms function cosmetics that are used to dispel comedo of 3 or 4 arbitrary claim, it is characterized in that said Sargassum polysaccharides is one or more the combination in sodium alginate, Porphyra Polysaccharide, Sargassum polysaccharide, Thallus Laminariae polysaccharide, sargassan, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma striatum polysaccharide, the Hijiki polysaccharide.
9. like claim 1,2, the described marine organisms function cosmetics that are used to dispel comedo of 3 or 4 arbitrary claim, it is characterized in that said Margarita powder is one or more the combination in nanometer Margarita powder, water soluble Margarita ultrafine powder, instant Margarita powder, the pearl hydrolysate liposome.
10. like claim 1,2, the described marine organisms function cosmetics that are used to dispel comedo of 3 or 4 arbitrary claim, it is characterized in that said marine organisms function cosmetics are cream frost, emulsion, water preparation, gel, spraying or facial film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210001804 CN102525864B (en) | 2012-01-05 | 2012-01-05 | Marine biological functional cosmetic for removing acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210001804 CN102525864B (en) | 2012-01-05 | 2012-01-05 | Marine biological functional cosmetic for removing acne |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102525864A true CN102525864A (en) | 2012-07-04 |
| CN102525864B CN102525864B (en) | 2013-06-12 |
Family
ID=46334698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210001804 Active CN102525864B (en) | 2012-01-05 | 2012-01-05 | Marine biological functional cosmetic for removing acne |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102525864B (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988262A (en) * | 2012-12-20 | 2013-03-27 | 中国科学院南海海洋研究所 | Bee venom composition with acne removing function |
| CN103169641A (en) * | 2013-03-14 | 2013-06-26 | 金红叶纸业集团有限公司 | Acne-removing and skin-clearing composition and tissue applying same |
| WO2016162648A1 (en) | 2015-04-10 | 2016-10-13 | Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic | Method for culturing cells of acrochaetium moniliforme red algae, method for obtaining an extract of the biomass thereof, and use of same in cosmetics |
| CN106619435A (en) * | 2016-10-19 | 2017-05-10 | 刘艺鹏 | Marine shellfish active peptide moisturizer |
| CN107427547A (en) * | 2015-03-24 | 2017-12-01 | 新西兰植物与食品研究所 | Water-soluble mussel extract |
| DK201600316A1 (en) * | 2016-05-27 | 2017-12-11 | Tingen Tech Co Ltd | Chinese drugs pharmaceutics for pimple scar elimination and the preparation method thereof |
| CN108210891A (en) * | 2018-04-03 | 2018-06-29 | 广州赛莱拉干细胞科技股份有限公司 | Wound healing compositions |
| CN108553326A (en) * | 2018-04-28 | 2018-09-21 | 浦江县昂宝生物技术有限公司 | Preparation method added with clam active polypeptide moisturizer |
| CN108785144A (en) * | 2018-09-04 | 2018-11-13 | 广东医科大学 | A kind of skin matrix and its application |
| CN109771449A (en) * | 2019-02-24 | 2019-05-21 | 温州大学 | A kind of Hijiki polysaccharide and its application with promotion wound healing effect |
| CN110433094A (en) * | 2019-08-27 | 2019-11-12 | 广东锦玛绿色食品科技有限公司 | A kind of cosmetics and preparation method thereof with skin nti-freckle repair function |
| CN111050846A (en) * | 2017-09-28 | 2020-04-21 | 优志旺电机株式会社 | Sterilization method and sterilization apparatus |
| CN111632013A (en) * | 2020-06-09 | 2020-09-08 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition, soothing and repairing powder preparation and preparation method thereof |
| CN111743830A (en) * | 2020-06-19 | 2020-10-09 | 广州天玺生物科技有限公司 | Acne-removing composition and application thereof |
| CN118059013A (en) * | 2024-04-17 | 2024-05-24 | 江苏亨瑞生物医药科技有限公司 | Moisturizing and water-locking body lotion containing collagen and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178636A (en) * | 2011-04-27 | 2011-09-14 | 中国科学院南海海洋研究所 | Marine biological function cosmetic for minimizing pores |
| CN102188332A (en) * | 2011-03-31 | 2011-09-21 | 中国科学院南海海洋研究所 | Cosmetic containing oceanic shellfish active peptide and preparation method and application thereof |
| CN102302417A (en) * | 2011-09-13 | 2012-01-04 | 佛山市安安美容保健品有限公司 | Comprehensive-effect sunscreen lotion containing oceanic biological active substances |
| CN102366383A (en) * | 2011-09-26 | 2012-03-07 | 佛山科学技术学院 | Marine organism functional cosmetic for nourishing skin around eyes |
-
2012
- 2012-01-05 CN CN 201210001804 patent/CN102525864B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188332A (en) * | 2011-03-31 | 2011-09-21 | 中国科学院南海海洋研究所 | Cosmetic containing oceanic shellfish active peptide and preparation method and application thereof |
| CN102178636A (en) * | 2011-04-27 | 2011-09-14 | 中国科学院南海海洋研究所 | Marine biological function cosmetic for minimizing pores |
| CN102302417A (en) * | 2011-09-13 | 2012-01-04 | 佛山市安安美容保健品有限公司 | Comprehensive-effect sunscreen lotion containing oceanic biological active substances |
| CN102366383A (en) * | 2011-09-26 | 2012-03-07 | 佛山科学技术学院 | Marine organism functional cosmetic for nourishing skin around eyes |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014094375A1 (en) * | 2012-12-20 | 2014-06-26 | 中国科学院南海海洋研究所 | Bee venom composition with acne removing effect |
| CN102988262A (en) * | 2012-12-20 | 2013-03-27 | 中国科学院南海海洋研究所 | Bee venom composition with acne removing function |
| CN103169641A (en) * | 2013-03-14 | 2013-06-26 | 金红叶纸业集团有限公司 | Acne-removing and skin-clearing composition and tissue applying same |
| CN103169641B (en) * | 2013-03-14 | 2016-01-13 | 金红叶纸业集团有限公司 | The light print compositions of anti-acne and apply its napkin |
| CN107427547A (en) * | 2015-03-24 | 2017-12-01 | 新西兰植物与食品研究所 | Water-soluble mussel extract |
| WO2016162648A1 (en) | 2015-04-10 | 2016-10-13 | Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic | Method for culturing cells of acrochaetium moniliforme red algae, method for obtaining an extract of the biomass thereof, and use of same in cosmetics |
| US11224627B2 (en) | 2015-04-10 | 2022-01-18 | Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic | Method for culturing cells of Acrochaetium moniliforme red algae, method for obtaining an extract of the biomass thereof, and use of same in cosmetics |
| DK201600316A1 (en) * | 2016-05-27 | 2017-12-11 | Tingen Tech Co Ltd | Chinese drugs pharmaceutics for pimple scar elimination and the preparation method thereof |
| CN106619435A (en) * | 2016-10-19 | 2017-05-10 | 刘艺鹏 | Marine shellfish active peptide moisturizer |
| CN111050846A (en) * | 2017-09-28 | 2020-04-21 | 优志旺电机株式会社 | Sterilization method and sterilization apparatus |
| US11642548B2 (en) | 2017-09-28 | 2023-05-09 | Ushio Denki Kabushiki Kaisha | Sterilization method and sterilization apparatus |
| CN108210891A (en) * | 2018-04-03 | 2018-06-29 | 广州赛莱拉干细胞科技股份有限公司 | Wound healing compositions |
| CN108553326A (en) * | 2018-04-28 | 2018-09-21 | 浦江县昂宝生物技术有限公司 | Preparation method added with clam active polypeptide moisturizer |
| CN108785144A (en) * | 2018-09-04 | 2018-11-13 | 广东医科大学 | A kind of skin matrix and its application |
| CN109771449A (en) * | 2019-02-24 | 2019-05-21 | 温州大学 | A kind of Hijiki polysaccharide and its application with promotion wound healing effect |
| CN110433094A (en) * | 2019-08-27 | 2019-11-12 | 广东锦玛绿色食品科技有限公司 | A kind of cosmetics and preparation method thereof with skin nti-freckle repair function |
| CN111632013A (en) * | 2020-06-09 | 2020-09-08 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition, soothing and repairing powder preparation and preparation method thereof |
| CN111743830A (en) * | 2020-06-19 | 2020-10-09 | 广州天玺生物科技有限公司 | Acne-removing composition and application thereof |
| CN118059013A (en) * | 2024-04-17 | 2024-05-24 | 江苏亨瑞生物医药科技有限公司 | Moisturizing and water-locking body lotion containing collagen and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102525864B (en) | 2013-06-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102525864B (en) | Marine biological functional cosmetic for removing acne | |
| CN102178636B (en) | Marine biological function cosmetic for minimizing pores | |
| CN102988262B (en) | Bee venom composition with acne removing function | |
| US20050244354A1 (en) | Oxygenated personal care products | |
| CN106580798A (en) | All-in-one eye cream and preparation method | |
| KR101183075B1 (en) | Porifera-based therapeutic compositions for treating and preventing skin diseases | |
| CN103191042A (en) | Skin care agent capable of removing freckles, whitening, preventing wrinkles, moisturizing and resisting allergy and ageing | |
| CN107714504A (en) | A kind of same human-like collagen composition and its applied in cosmetics | |
| CN104586695A (en) | Skin care product containing cactus essence and having deep water-replenishing and moisturizing effects | |
| CN109998937B (en) | Cosmetic series containing glycerol glucoside (alpha GG) and preparation method thereof | |
| GB2451224A (en) | Cosmetic composition comprising an exfoliant, astringent, antioxidant and moisturiser | |
| CN107303253A (en) | It is a kind of to be used to be damaged renovation agent of skin and preparation method thereof | |
| US20070172431A1 (en) | Methods, systems and compositions for skin care | |
| CN107822945A (en) | One kind is matched unartificial yeast composition, preparation method and applied in cosmetics | |
| CN112006958A (en) | Depilatory cream and preparation method thereof | |
| CN110721117A (en) | Freeze-dried powder preparation of beauty and skin care cosmetics and application of freeze-dried powder preparation in solution | |
| CN108542851A (en) | A kind of Chinese medicine moisturizing anti-chapping hand cream and preparation method thereof | |
| CN104490713A (en) | Super-soft living spring skin care product with functions of removing foul, tightening, resisting wrinkles and activating skin | |
| KR20090038648A (en) | A composition using the cosmetic containing chamaecyparis obtusa oil for a pimpled skin | |
| CN108056931A (en) | A kind of acne eliminating cream and preparation method thereof | |
| CN113133967A (en) | Peony essence skin-moistening facial cream and preparation method thereof | |
| CN105169457A (en) | Cationic medical dressing and preparation method thereof | |
| CN106727251A (en) | A kind of natural bee venom gel frost and its preparation technology | |
| CN108938514B (en) | Skin-clearing acne-removing liquid and preparation method thereof | |
| CN115120548A (en) | Long-acting moisturizing repairing water and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |