CN105169457A - Cationic medical dressing and preparation method thereof - Google Patents
Cationic medical dressing and preparation method thereof Download PDFInfo
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- CN105169457A CN105169457A CN201510529263.6A CN201510529263A CN105169457A CN 105169457 A CN105169457 A CN 105169457A CN 201510529263 A CN201510529263 A CN 201510529263A CN 105169457 A CN105169457 A CN 105169457A
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Abstract
The invention relates to a cationic medical dressing and a preparation method thereof. The cationic medical dressing is composed of the following raw materials in percent by weight: 1.2%-2% of chitosan quaternary ammonium salt, 0.2%-0.35% of polyhexamethyleneguanidine, 0.2%-0.7% of magnesium ascorbyl phosphate, 0.005%-0.015% of a cell growth factor, 0.2%-0.5% of ceramide, 0.15%-0.25% of allantoin, 0.08%-0.16% of camellia oil, 6%-10% of glycerin, 0.5%-0.7% of peppermint oil, and the balance purified water. The cationic medical dressing is capable of performing rapid restoration and sterilization processing on damaged skin without leaving a scar, is capable of isolating and killing bacteria, fungus and virus, and preventing skin and mucous membrane from being infected, possesses functions of stopping bleeding and keeping wound moist, also is capable of promoting wound skin to be restored and healed, and is widely applicable to prevention and treatment of skin wound infection and local mucous membrane infection of oral cavity, throat, gum and the like.
Description
Technical field
The present invention relates to technique in skin care field, particularly relate to a kind of cation medical dressing and preparation method thereof.
Background technology
In the developmental process of people, be subject to extraneous injury unavoidably, as scratch, burn and scald, decubital ulcer, hemorrhoid etc., after skin is subject to severe trauma, its wound site easily suffers the infection of antibacterial, fungus and virus, after infection, need the long period to recover, may scar be left simultaneously.
Summary of the invention
The object of the invention is to solve the deficiencies in the prior art, a kind of cation medical dressing and preparation method thereof is provided, can nurses wound site, to the isolation of antibacterial, fungus, virus; Make wound site Fast Restoration; And can avoid leaving scar.
For achieving the above object, the technical solution used in the present invention is:
A kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.2% ~ 2%
Polyhexamethylene guanidine 0.2% ~ 0.35%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.2% ~ 0.7%
Cell growth factor 0.005% ~ 0.015%
Ceramide 0.2% ~ 0.5%
Allantoin 0.15% ~ 0.25%
Camellia oil 0.08% ~ 0.16%
Glycerol 6% ~ 10%
Oleum menthae 0.5% ~ 0.7%
Purified water surplus.
Water instant cation chitosan quaternary ammonium salt has the performances such as good antibiotic property, film property, cation-adsorption, moisture absorbability and moisture retentivity, flocculability, antistatic behaviour.Its anti-microbial property is better than chitosan and other chitosan derivatives.After chitosan quaternary ammonium salt is water-soluble, ionize, containing a large amount of level Four ammonium cations in solution.Ammonium cation has certain fragmentation effect to antibacterial, fungus, virus.
Secondly polyhexamethylene guanidine, has broad-spectrum; Valid density is low; Speed of action is fast; Stable in properties; Premium properties soluble in water; Can use at normal temperatures; For a long time antibacterial, have no side effect; Polyhexamethylene guanidine is polyguanidine family macromolecule polymer, ionization can be produced in aqueous, its hydrophilic group part contains strong electropositive, absorption is usually in electronegative each bacterioid, virus, enter cell membrane, suppress the synthesis of film lactone plastid, cause thalline apoptosis, reach best bactericidal effect.
Chitosan quaternary ammonium salt, polyhexamethylene guanidine produce and form cation, can kill antibacterial, fungus and virus and isolate.
Magnesium L-Asacorbic Acid 2-O-Phosphate is vitamin C derivatives, be that raw material modern science and technology process with vitamin C, no matter oral this product is or after being absorbed entered human body by skin, all to dissociate vitamin C by the rapid enzymolysis of phosphate, play the distinctive biochemical functions of vitamin C.
Magnesium L-Asacorbic Acid 2-O-Phosphate is a kind of water solublity whitening agent.This product is after skin absorbs, effectively can resist ultraviolet invasion and attack, and can oxygen-derived free radicals be caught, promote that collagen protein generates, effectively can prevent and treat pigmentation, dispel various skin splash, skin moisturizing, delicate, bright and clean and this product can be made to stablize, nontoxic, non-stimulated, for the excellent additive of modern functional skin-lightening cosmetic, also have: 1, tyrosinase activity processed, vat black pigment, the effect of tool freckle removing and whitening.2, enter after in body and can eliminate oxygen-derived free radicals, thus there is wrinkle removing, anti-senescence function.3, synergism is had with vitamin E.
Cell growth factor is a kind of multifunctional powerful cytokine, to promoting that the formation of fibroblastic metabolism and collagen protein plays critical function.Cell growth factor can promote the growth and breeding of skin histology, and it is by being combined with specific cell surface receptors, regulation and control skin epidermis, and the division of endothelium and stromal cell, Growth and Reproduction differentiation, promote cellular metabolism, strengthen Oxidation; Can promote to breed with the ramp of skin injury cells involved, and regulate the synthesis of intercellular matrix, secretion and decomposition; The regeneration of corneocyte can be promoted, accelerate the reparation of keratodermatitis and hypothallus, promote the growth of human skin cell; Synthesis and the cellular metabolism of the protein of Skin Cell can be strengthened, there is skin-cell aging delaying, the reparation promoting epidermis cell and growth, make skin smooth plump.
Glycerol, namely glycerol is without the sweet clear and bright thick liquid of color and taste, odorless; There is warm sweet taste.Glycerol can moisture content in draw air to skin moisture-keeping, also the moisture content in skin can be pinned, not allow it run off.There is effect of moisturizing.Moisturizing, moist effect can be played to the skin of baby.
Oleum menthae, skin that is unclean, that block can be nursed one's health, its refrigerant sensation, can blood capillary be shunk, releive itch, inflammation and burning, also can soft skin, also effect is had for removing blackhead and oiliness skin quality.
Oleum menthae has inhibitory action to herpes simplex virus, forest virus, mumps virus, has bacteriostasis to staphylococcus aureus, Staphylococcus albus, alpha streptococcus, group B streptococcus, micrococcus catarrhalis, enteritis coccus, shigella flexneri, anthrax bacillus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, escherichia coli etc.; Water solublity Oleum menthae can excite nerve tip cold receptor and produce creeping chill, and reflexive cause the change of deep tissue blood vessel and play antiinflammatory, pain relieving, antipruritic effect.
Ceramide, also known as sphingolipid, is a kind of lipid being present in skin, plays an important role in epidermal keratinocytes layer formation process.When drying, desquamation, cracking phenomena appear in skin, when its barrier function obviously reduces, skin supplements ceramide can recover rapidly moisturizing and barrier function.
Cause xerosis cutis main cause to be that in horny layer of epidermis, ceramide content reduces, ceramide content height is directly related with skin dryness.Use ceramide can obviously strengthen adhesion strength between keratinocyte, improve skin dryness, reduce desquamation phenomenon.Ceramide has very strong associated water molecule ability, and it maintains moisture of skin by forming network structure in horny layer.Therefore, ceramide has the effect of maintenance moisture of skin.Use ceramide that ceramide content in horny layer of epidermis can be made to increase, xerosis cutis, desquamation, the situation such as coarse can be improved; Ceramide can increase epidermal keratinocytes layer thickness simultaneously, improves skin moisture holding capacity, reduces wrinkle, strengthens skin elasticity, delay skin aging.
Ceramide is a kind of water-soluble grease metallic substance, and it is close with the structure of matter forming keratodermatitis, can penetrate into skin very soon, and the water in horny layer combines, and forms a kind of network structure, pins moisture.
Allantoin: another name Allantoin, Allantoin, Allantion, Allantoin are a kind of hydantoin derivatives.Be a kind of nontoxic, tasteless, nonirritant, without hypersensitive white crystal, in water, crystallization is single prism or colorless crystalline powder.Hot water, hot alcohol and diluted sodium hydroxide solution can be dissolved in.Be slightly soluble in water and the alcohol of room temperature, be insoluble in the organic solvents such as EC; Its saturated aqueous solution (concentration is 0.6%) is in subacidity; PH is 5.5.Be stable in the aqueous solution of 4-9 at pH value.Also stablize in nonaqueous solvent and dry air; Boil in strong alkali solution and decomposable asymmetric choice net under solar exposure.For cell growth factor improves weakly acidic condition.
The physiological functions such as allantoin has Promote cell's growth, accelerating wound, horny layer softening albumen are good consolidant and the antiulcer agents of skin trauma.Can be used as alleviating and treatment xeroderma, scaling skin illness, skin ulcer, digestive tract ulcer and inflammation, all have good therapeutic effect to osteomyelitis, diabetes, liver cirrhosis, acne.
Because allantoin is a kind of amphoteric compound, double salt can be formed in conjunction with many kinds of substance, there is lucifuge, sterilization and anticorrosion, pain relieving, antioxidation, skin can be made to keep moisture content, moist and soft, be the additive of the cosmetics such as cosmetology, be widely used in the additive of freckle cream, anti-acne toner, shampoo, fancy soap, toothpaste, shaving lotion, conditioner, astringent, anti-antiperspirant deodorization lotion etc.Add the cosmetics of allantoin have protective tissue, hydrophilic, absorb water and the effect such as prevent that moisture from distributing; Add suppurative mastitis, hair cream, the shampoo of allantoin, have protective effect to hair, can make hair not bifurcated, constantly send out; The lip pomade of interpolation allantoin, facial cream can make skin, lip soft and high resilience, and have beautiful gloss.Allantoin promotes tissue growth, cell metabolism, soften cuticle albumen.
Camellia oil is nutritious, fatty acids (unsaturated fatty acid 93%, wherein oleic acid 82%, linoleic acid 11%), camellianin, tea polyphenols, Saponin, tannin, and being rich in antioxidant and the Squalene with anti-inflammatory effect, Squalene and Flavonoid substances, have splendid effect to anticancer.Camellia oil is the trace element such as rich in vitamin E and calcium, ferrum, zinc also, and be described as the zinc element of " flowers of life " by physician and nutritionist, content is 10 times of soybean oil, and therefore Camellia oil owing to having good lubricant effect containing a large amount of fatty acids.
After skin is subject to wound, the easy breed bacteria of site of injury etc., chitosan quaternary ammonium salt, polyhexamethylene guanidine produce a large amount of cation, may be used for sterilization; The not infected tissue of avoiding of wound surface is made to produce a large amount of leukocyte formation cicatrixes; Oleum menthae assisting sterilisation simultaneously.Glycerol, Camellia oil play the effect of lubrication, skin care, coordinate with ceramide, keep the moisture of skin, avoid drying, pigementation; Secondly Camellia oil also plays antiinflammatory, and its effective ingredient Squalene can promote the generation of collagen protein, promotes that new skin histology grows; Ceramide can also play anti-allergic effects.Allantoin coordinates with cell growth factor, promotes dermal cell growth, repairs the cell by wound, promotes wound healing; Allantoin also plays soften cuticle albumen, removes the effect of dead bark, prevents dead bark from hindering new skin histology to grow.Magnesium L-Asacorbic Acid 2-O-Phosphate can catch oxygen-derived free radicals, promotes that collagen protein generates, effectively can prevent and treat pigmentation, dispel various skin splash, can make skin moisturizing; Mainly play antioxidation and whitening effect.
Preferably, the content summation of chitosan quaternary ammonium salt and polyhexamethylene guanidine is no more than 2.3%.These two kinds of compositions, while sterilization, may hurt the leukocyte in Skin Cell and skin histology; By clinical trial analysis, when its weight is more than a timing, leukocyte work can be had influence on.
Preferably, a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.3% ~ 1.8%
Polyhexamethylene guanidine 0.3% ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.3% ~ 0.6%
Cell growth factor 0.008% ~ 0.012%
Ceramide 0.2% ~ 0.4%
Allantoin 0.17% ~ 0.23%
Camellia oil 0.08% ~ 0.12%
Glycerol 7% ~ 9%
Oleum menthae 0.5% ~ 0.7%
Purified water surplus.
Again preferably, a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.5%
Polyhexamethylene guanidine 0.3%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.5%
Cell growth factor 0.01%
Ceramide 0.3%
Allantoin 0.2%
Camellia oil 0.1%
Glycerol 8%
Oleum menthae 0.6%
Purified water surplus.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Preferably, a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.3% ~ 1.8%
Polyhexamethylene guanidine 0.3% ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.3% ~ 0.6%
Cell growth factor 0.008% ~ 0.012%
Ceramide 0.2% ~ 0.4%
Allantoin 0.17% ~ 0.23%
Camellia oil 0.08% ~ 0.12%
Glycerol 7% ~ 9%
Oleum menthae 0.5% ~ 0.7%
Aloin 0.8% ~ 1%
Purified water surplus.
Aloin can help to discharge dirt in body, purifies the blood, vessel softening, reduces blood pressure and blood viscosity, blood circulation promoting; The mixture of active component based on barbaloin is dicotyledon Aloe extract.Bactericidal action, antiinflammatory action, moistening beautification function, lets out effect under stomach invigorating, the heart tonifying effect of invigorating blood circulation, immunity and regeneration, immunity and antitumor action, Detoxication, anti-aging effects, analgesia, sedation, anti-sunlight function.The polysaccharide contained in Aloe and multivitamin have good nutrition, moist, whitening effect to human body skin.Aloe Barbadensis Miller is the Fresh leaf of aloe that optimum is directly improved looks, i.e. Aloe vulgaris, and it has the performance making skin contraction, softnessization, moisturizing, antiinflammatory, bleaching.Remove sclerosis, keratinization in addition, improve the effect of scar, little wrinkle, eye pouch, cutis laxa can not only be prevented, skin wet, tender and lovely can also be kept, simultaneously, can also scytitis be treated, also have good curative effect to acne, freckle, acne and scald, knife injury, insect bite etc.Effective too to hair, hair can be made to keep moistening smooth, pre-Anti-hair loss.
When skin is subject to wound, sometimes along with hemorrhage; Especially scald, also can along with inflammation; In dressing, increase a certain amount of aloin, certain haemostatic effect and antibacterial, antiinflammatory can be played; By clinical trial, do not conflict with other drug composition.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae, aloin;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Further preferably, a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.3% ~ 1.8%
Polyhexamethylene guanidine 0.3% ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.3% ~ 0.6%
Cell growth factor 0.008% ~ 0.012%
Ceramide 0.2% ~ 0.4%
Allantoin 0.17% ~ 0.23%
Camellia oil 0.08% ~ 0.12%
Glycerol 7% ~ 9%
Oleum menthae 0.5% ~ 0.7%
Aloin 0.8% ~ 1%
Hydrogen peroxide 1% ~ 2%
Purified water surplus.
Hydrogen peroxide has good oxidation effectiveness, when adopting the wound of the hydrogen peroxide of low concentration (especially weight ratio is lower than 3%) and skin, pus or dirt to meet, decomposes immediately and generates oxygen.This oxygen atom being not yet combined into oxygen molecule, has very strong oxidability, when contacting with antibacterial, can destroy microorganism, kill antibacterial.Can provide an aerobic environment, the collagen protein killing anaerobe and aid in skin is formed simultaneously.Here the content of hydrogen peroxide refers to: the weight content of hydrogen peroxide in whole dressing: 1% ~ 2%.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae, aloin, hydrogen peroxide;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Because content 100% hydrogen peroxide is difficult to obtain, the hydrogen peroxide of the quality such as the hydrogen peroxide employing in step one, other concentration hydrogen peroxide substitute; I.e. step one, join get hydrogen peroxide time, other concentration hydrogen peroxide getting equivalent can being joined, getting 30% hydrogen peroxide (quality containing hydrogen peroxide is equal) of equal size hydrogen peroxide as joined; Step 2 replaces with: the purified water taking surplus.
Beneficial effect of the present invention is:
1), adopt chitosan quaternary ammonium salt, polyhexamethylene guanidine etc. to have bactericidal effect to skin trauma position, avoid subinfection again;
2), adopt glycerol, Flos Camelliae Japonicae wet goods can maintain skin trauma position, avoid skin to lose moisture from wound site.
3), secondly, adopt and repair composition, skin is repaired, avoids occurring cicatrix.
Fast skin reparation can be reached, and do not leave scar.
Detailed description of the invention
Below the present invention is described further.
Embodiment 1: a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.2%
Polyhexamethylene guanidine 0.35%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.2%
Cell growth factor 0.015%
Ceramide 0.5%
Allantoin 0.15%
Camellia oil 0.08%
Glycerol 10%
Oleum menthae 0.5%
Purified water surplus.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 1:
Huang, man, 11 years old, arm was scalded by boiled water, and wound has suppuration, after wound cleaning, smeared the cation medical dressing one month of the present embodiment, every day 3 times; Wound healing, and substantially without scar.
Embodiment 2: a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 2%
Polyhexamethylene guanidine 0.2%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.7%
Cell growth factor 0.005%
Ceramide 0.2%
Allantoin 0.25%
Camellia oil 0.16%
Glycerol 10%
Oleum menthae 0.6%
Purified water surplus.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 2
Zhang, female, 10 years old, arm was scalded by oil; Arm is got blister; After treatment of wounds, the cation medical dressing of coating the present embodiment 3 weeks, every day 3 times, wound takes a turn for the better; New skin tissue growth, and scar is very light; Continue use 2 weeks again, wound healing, without scar.
Embodiment 3: a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.3%
Polyhexamethylene guanidine 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.6%
Cell growth factor 0.012%
Ceramide 0.4%
Allantoin 0.17%
Camellia oil 0.12%
Glycerol 7%
Oleum menthae 0.5%
Purified water surplus.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 3
Lin, man, 10 years old, after injured with it, injury ulcer, there is pigementation in trauma skin periphery; The cation medical dressing of coating the present embodiment one week, every day at least 3 times, ulcer place starts abatement; Continue use 3 weeks, pigment disappears, wound healing.
Embodiment 4: a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.5%
Polyhexamethylene guanidine 0.3%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.5%
Cell growth factor 0.01%
Ceramide 0.3%
Allantoin 0.2%
Camellia oil 0.1%
Glycerol 8%
Oleum menthae 0.6%
Purified water surplus.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 4:
Lee, man, 15 years old, falls down arm scratch in running; Skin starts to have ulcer sign and with inflammation; After the cleaning of wound portion, the cation medical dressing of film the present embodiment one week, every day 3 times, inflammation starts abatement, new skin tissue growth; Cure after 4 weeks.
Embodiment 5: a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.3%
Polyhexamethylene guanidine 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.6%
Cell growth factor 0.008%
Ceramide 0.4%
Allantoin 0.17%
Camellia oil 0.12%
Glycerol 9%
Oleum menthae 0.5%
Aloin 0.8%
Purified water surplus.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae, aloin;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 5
Zhang, man, 15 years old, suffers from hemorrhoid; Skin is scratched, pruritus, and has pigment to start precipitation; Use the cation medical dressing of the present embodiment after one week, coating at least 3 times every day, pruritus disappear gradually or weaken, pigment removal; After 4 weeks, scabies starts to scab and cures and non-pigment precipitation.
Embodiment 6: a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.8%
Polyhexamethylene guanidine 0.3%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.3%
Cell growth factor 0.012%
Ceramide 0.2%
Allantoin 0.17%
Camellia oil 0.08%
Glycerol 7%
Oleum menthae 0.7%
Aloin 1%
Purified water surplus.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae, aloin;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 6
Lin, man, 32 years old, suffers from skin eczema; Skin is scratched, pruritus, and has inflammation; Use the cation medical dressing of the present embodiment after one week, every day at least 3 times, pruritus disappear gradually or weaken, inflammation slows down; After 4 weeks, start the healing that scabs.
Embodiment 7: a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.6%
Polyhexamethylene guanidine 0.31%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.4%
Cell growth factor 0.01%
Ceramide 0.3%
Allantoin 0.2%
Camellia oil 0.1%
Glycerol 8%
Oleum menthae 0.6%
Aloin 0.9%
Purified water surplus.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae, aloin;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 7
Field, female, 41 years old, suffers from eczema; Skin is scratched, pruritus, and occurs red point; Use the cation medical dressing of the present embodiment after one hour, pruritus disappears gradually or weakens; After 6 hours, red point disappears.
Embodiment 8: a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.3%
Polyhexamethylene guanidine 0.3%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.6%
Cell growth factor 0.012%
Ceramide 0.2%
Allantoin 0.17%
Camellia oil 0.08%
Glycerol 9%
Oleum menthae 0.7%
Aloin 1%
Hydrogen peroxide 2%
Purified water surplus.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae, aloin, hydrogen peroxide;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Because content 100% hydrogen peroxide is difficult to obtain, the hydrogen peroxide of the quality such as the hydrogen peroxide employing in step one, other concentration hydrogen peroxide substitute; I.e. step one, join get hydrogen peroxide time, other concentration hydrogen peroxide getting equivalent can being joined, getting 30% hydrogen peroxide (quality containing hydrogen peroxide is equal) of equal size hydrogen peroxide as joined; Step 2 replaces with: the purified water taking surplus.
Case 8: Zhang, female, 32 years old, is burned, and epidermis has ulcer, blister; After wound cleaning, smear the cation medical dressing of the present embodiment, wound scabs, every day at least 3 times, and after one week, wound starts healing, new skin tissue growth, and pigementation appears in wound perimeter; After 4 weeks, wound healing; Pigment disappears; Without cicatrix.
Embodiment 9:
A kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.8%
Polyhexamethylene guanidine 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.3%
Cell growth factor 0.008%
Ceramide 0.4%
Allantoin 0.23%
Camellia oil 0.12%
Glycerol 7%
Oleum menthae 0.5%
Aloin 0.8%
Hydrogen peroxide 1%
Purified water surplus.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae, aloin, hydrogen peroxide;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Because content 100% hydrogen peroxide is difficult to obtain, the hydrogen peroxide of the quality such as the hydrogen peroxide employing in step one, other concentration hydrogen peroxide substitute; I.e. step one, join get hydrogen peroxide time, other concentration hydrogen peroxide getting equivalent can being joined, getting 30% hydrogen peroxide (quality containing hydrogen peroxide is equal) of equal size hydrogen peroxide as joined; Step 2 replaces with: the purified water taking surplus.
Case 9: close certain, female, 63 years old, falls down skin and be scratched, and part wound is darker; After wound cleaning, the cation medical dressing of coating the present embodiment, every day at least 3 times, wound starts to scab, healing after a week; Without Infective morbidity; And without cicatrix.
Embodiment 10: a kind of cation medical dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.5%
Polyhexamethylene guanidine 0.3%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.5%
Cell growth factor 0.01%
Ceramide 0.3%
Allantoin 0.2%
Camellia oil 0.1%
Glycerol 8%
Oleum menthae 0.6%
Aloin 1%
Hydrogen peroxide 2%
Purified water surplus.
A preparation method for above-mentioned cation medical dressing, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae, aloin, hydrogen peroxide;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Because content 100% hydrogen peroxide is difficult to obtain, the hydrogen peroxide of the quality such as the hydrogen peroxide employing in step one, other concentration hydrogen peroxide substitute; I.e. step one, join get hydrogen peroxide time, other concentration hydrogen peroxide getting equivalent can being joined, getting 30% hydrogen peroxide (quality containing hydrogen peroxide is equal) of equal size hydrogen peroxide as joined; Step 2 replaces with: the purified water taking surplus.
Case 10: Zhang, man, 41 years old, suffers from herpes; There is ulcer local; The cation medical dressing of coating the present embodiment, every day at least 3 times, after continuous 5 days, ulcer wound starts to scab, and after 3 weeks, herpes starts to eliminate; And without cicatrix.
Below be only the preferred embodiment of the application, equivalent technical solutions on this basis still falls into application protection domain.
Claims (8)
1. a cation medical dressing, is characterized in that: be made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.2% ~ 2%
Polyhexamethylene guanidine 0.2% ~ 0.35%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.2% ~ 0.7%
Cell growth factor 0.005% ~ 0.015%
Ceramide 0.2% ~ 0.5%
Allantoin 0.15% ~ 0.25%
Camellia oil 0.08% ~ 0.16%
Glycerol 6% ~ 10%
Oleum menthae 0.5% ~ 0.7%
Purified water surplus.
2. a kind of cation medical dressing according to claim 1, is characterized in that: be made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.3% ~ 1.8%
Polyhexamethylene guanidine 0.3% ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.3% ~ 0.6%
Cell growth factor 0.008% ~ 0.012%
Ceramide 0.2% ~ 0.4%
Allantoin 0.17% ~ 0.23%
Camellia oil 0.08% ~ 0.12%
Glycerol 7% ~ 9%
Oleum menthae 0.5% ~ 0.7%
Purified water surplus.
3. a kind of cation medical dressing according to claim 1, is characterized in that: be made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.5%
Polyhexamethylene guanidine 0.3%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.5%
Cell growth factor 0.01%
Ceramide 0.3%
Allantoin 0.2%
Camellia oil 0.1%
Glycerol 8%
Oleum menthae 0.6%
Purified water surplus.
4. a cation medical dressing, is characterized in that: be made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.3% ~ 1.8%
Polyhexamethylene guanidine 0.3% ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.3% ~ 0.6%
Cell growth factor 0.008% ~ 0.012%
Ceramide 0.2% ~ 0.4%
Allantoin 0.17% ~ 0.23%
Camellia oil 0.08% ~ 0.12%
Glycerol 7% ~ 9%
Oleum menthae 0.5% ~ 0.7%
Aloin 0.8% ~ 1%
Purified water surplus.
5. a cation medical dressing, is characterized in that: be made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.3% ~ 1.8%
Polyhexamethylene guanidine 0.3% ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.3% ~ 0.6%
Cell growth factor 0.008% ~ 0.012%
Ceramide 0.2% ~ 0.4%
Allantoin 0.17% ~ 0.23%
Camellia oil 0.08% ~ 0.12%
Glycerol 7% ~ 9%
Oleum menthae 0.5% ~ 0.7%
Aloin 0.8% ~ 1%
Hydrogen peroxide 1% ~ 2%
Purified water surplus.
6. a preparation method for the arbitrary described cation medical dressing of claims 1 to 3, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
7. a preparation method for cation medical dressing according to claim 4, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae, aloin;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
8. a preparation method for cation medical dressing according to claim 5, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, Magnesium L-Asacorbic Acid 2-O-Phosphate, ceramide, cell growth factor, allantoin, Camellia oil, glycerol, Oleum menthae, aloin, hydrogen peroxide;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106581654A (en) * | 2016-12-27 | 2017-04-26 | 青岛琛蓝海洋生物工程有限公司 | Composite skin wound disinfectant and preparation method thereof |
| CN107198790A (en) * | 2017-05-25 | 2017-09-26 | 李美英 | A kind of degradable dressing of animal doctor's antibiotic-free |
| WO2017206017A1 (en) * | 2016-05-30 | 2017-12-07 | 江苏奇力康皮肤药业有限公司 | Ointment for rapidly repairing surfaces of burn and scald wounds |
| CN108619083A (en) * | 2018-04-19 | 2018-10-09 | 江苏理工学院 | A kind of medical reparation dressing of skin and preparation method thereof |
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| CN106581654A (en) * | 2016-12-27 | 2017-04-26 | 青岛琛蓝海洋生物工程有限公司 | Composite skin wound disinfectant and preparation method thereof |
| CN107198790A (en) * | 2017-05-25 | 2017-09-26 | 李美英 | A kind of degradable dressing of animal doctor's antibiotic-free |
| CN108619083A (en) * | 2018-04-19 | 2018-10-09 | 江苏理工学院 | A kind of medical reparation dressing of skin and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN105169457B (en) | 2018-03-23 |
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