CN105853260A - Cream for treating diaper dermatitis and preparation method thereof - Google Patents

Cream for treating diaper dermatitis and preparation method thereof Download PDF

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Publication number
CN105853260A
CN105853260A CN201510027174.1A CN201510027174A CN105853260A CN 105853260 A CN105853260 A CN 105853260A CN 201510027174 A CN201510027174 A CN 201510027174A CN 105853260 A CN105853260 A CN 105853260A
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diaper dermatitis
extract
fat
frost
skin
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CN105853260B (en
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楼彪
卢正君
付绪红
郭文华
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Hangzhou Weikela Investment Co ltd
Yu Qiongfei
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When Johnson Chemical (hangzhou) Ltd By Share Ltd
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Abstract

The invention discloses a cream for treating diaper dermatitis. The cream comprises the following raw materials by mass percentage: 30-50% of petrolatum, 20-40% of water, 10-30% of shea butter, 1-2% of polyglyceryl-2 distearate, 0.5-1.5% of microcrystalline wax, 0.1-0.3% of meadowfoam seed oil, 0.1-0.3% of a borago officinalis extract, 0.1-0.5% of menthyl lactate, 0.1-0.3% of bisabolol, 0.005-0.015% of brassinostsroids, 0.1-0.3% of calendula flower oil, 0.1-0.3% of chamomile oil, 0.03-0.09% of dehydroacetic acid, and 0.5-0.9% of phenylcarbinol. The invention provides the cream for treating diaper dermatitis which is healthier to a user and has more excellent effect as well as a preparation method thereof.

Description

A kind of diaper dermatitis frost and preparation method thereof
Technical field
The present invention relates to a kind of dermatitis frost, more specifically, it relates to a kind of diaper dermatitis frost and preparation method thereof.
Background technology
Diaper dermatitis, is commonly called as red hip, also known as diaper rash, is skin disease common in baby, refers to betide the limitation sheet erythema at baby' diaper packing position or the illness of unboiled water bubble, is a kind of dermal inflammatory pathology.For the scytitis that ewborn infant is common, how because of the body of children's's blood-head, skin and flesh is tender and lovely, and wet diaper impregnated for a long time, and damp and hot gas is handed over and steamed, and causes skin buttocks of falling into oblivion and forms, and this disease is more common in baby.
Produce a lot of because have of diaper dermatitis, most importantly skin of buttock is the moistest, sultry, the excitor substance in ight soil and urine can make skin damage occur that little hip are rubescent, and the scabies secondary infection on damaged skin of the microorganism such as bacterium, fungi more can increase the weight of the degree of red hip.Concrete show as the rubefaction of buttocks and diaper contact area, swell, even occur festering, ulcer and infection, the slightest external force or rub and will cause damage.It is the disease on a kind of skin, if nursing is good, the morning of action, typically within 2-3 days, can take a turn for the better, if but nurse not in time, or the method used is improper, will exert an adverse impact, the skin injury of baby can be brought unnecessary trouble to the life usually of baby and household.
At present, some stern protection creams on market, often for the curative effect reached, and use some ointment containing hormone to treat.And use the hormone of excess can resist the situation of infant physical growth or make some side effects such as thinning of skin or pigment deposition, growing baby has adverse effect on.And some common ointment, not only because the reason of its composition often but also does not reaches effect of well treatment.
Summary of the invention
The deficiency existed for prior art, it is an object of the invention to provide a kind of more healthy to user, diaper dermatitis frost that effect is more excellent and preparation method thereof.
For achieving the above object, the technical scheme is that a kind of diaper dermatitis frost, it is mixed by following raw material, calculates by mass percentage, is respectively as follows:
Percentage composition
Vaseline 30-50
Water 20-40
Butyrospermum parkii fruit fat 10-30
Polyglycereol-2 distearate 1-2
Microwax 0.5-1.5
White pond flower seed oil 0.1-0.3
Borage extract 0.1-0.3
Menthanol lactic acid ester 0.1-0.5
Bisabolol 0.1-0.3
Campesterol class 0.005-0.015
Pot marigold caul-fat 0.1-0.3
German chamomile caul-fat 0.1-0.3
Dehydroactic acid 0.03-0.09
Phenmethylol 0.5-0.9
The present invention is further arranged to: further comprises hydrolysed rice albumen, and its mass percent is 0.2-0.6.
The present invention is further arranged to: further comprises purslane extract, and its mass percent is 3-7.
The present invention is further arranged to: further comprises ginger-root extract, and its mass percent is 0.05-0.15.
Invention further provides the preparation method of a kind of diaper dermatitis frost, as follows:
S1: water, purslane extract and hydrolysed rice protein mixture are heated to 60 DEG C-80 DEG C and stir so that it is dissolve the formation aqueous phase material that is uniformly dispersed;
S2: vaseline, Butyrospermum parkii fruit fat, polyglycereol-2 distearate, microwax and Bai Chi flower seed oil mixture are heated to 65 DEG C-80 DEG C and stir so that it is dissolves the formation oil phase material that is uniformly dispersed;
S3: by aqueous phase material and oil phase material mix and blend, and emulsifying 9-15 minute in the environment of vacuum, be subsequently cooled to 40 DEG C-50 DEG C, vacuumize;
S4: add the essence preservative including borage extract, menthanol lactic acid ester, bisabolol, ginger-root extract, campesterol class, german chamomile caul-fat, dehydroactic acid and phenmethylol in the product that will prepare in S3, be sufficiently stirred for homogeneous 4 minutes;
S5: the product prepared in S4 is cooled to 25 DEG C-35 DEG C, discharging;Sampling censorship, after the inspection of semifinished product is qualified, enter filling operation filling, packaging.
By using technique scheme, concrete function and the effect of each chemical composition added in diaper dermatitis frost are described below:
Vaseline: be commonly called as vaseline, is considered typical cosmetic vehicle, is widely used in cosmetics and skin treating.Vaseline is the pure material obtained from oil, is made up of multiple long-chain fat race hydrocarbon.Since Middle Ages, vaseline is just used for skin nursing, is the most still listed in pharmacopeia.In practical dermatology, vaseline had both been used as patch test or dispenser excipient, also served as subsidy cosmetic vehicle.Can bring significant effect for improving scaly dry skin, it is internal containing abundant Alphalin, the most oily oiliness, can infiltrate into rapidly skin internal layer, persistently moisten to skin;Form special diaphragm on its surface with moisture-locking simultaneously, releive dry.Make the tender cunning of skin thin, dynamic and elastic.
Butyrospermum parkii fruit fat: be abundant moisturizing agent, it is easy to absorb, rich in unrighted acid, the moisture-retaining capacity of skin can be strengthened, the skin that dryness and cutin are impaired can be moistened, Ka Lite tree extract.Relative to other plant oil, containing highest rate fat accompaniment, particularly grow triterpene alcohol and vitamin E, vitamin A, the allantoin etc. of the nutrient of necessity, nutritious.It is prevented from skin water loss, helps healing of wound, increase skin defence capability and compliance, be rare skin care natural component.Green healthy to user has no side effect.
Polyglycereol-2 distearate: ion acidproof, resistance to, resistance to 120 DEG C of high temperature, can be with nonionic, anion, cationic surfactant compatibility, plant origin, gentle, non-stimulated, good water solubility.It is a kind of well emulsifying agent, excellent effect.
Microwax: for white to faint yellow tiny acicular crystals, odorless, tasteless, being a kind of refined synthetic wax approximating crystallite character, have good luster, fusing point is high, the feature of lighter color, its close structure, hard and lubricious, can melt mutually with various native paraffins, and the fusing point of its low wax can be improved, improve the performance of thick property wax.There is good oil absorbency, stable, uniform lotion can be formed with multi-solvents, wax class, and have emulsibility, can use as adhesive in this diaper dermatitis frost as processing aid.
White pond flower seed oil: Limnanthes Alba Seed Oil namely Meadowfoam Seed Oil, translator of Chinese is meadow sweet seed oil, pond flower seed oil, and also someone is white awns flower seed oil, McDonnell Douglas sweet smell flower seed oil, edelweiss extraction oil.At room temperature being in a liquid state, tasteless and non-greasy, skinfeel is the dryest and the comfortableest, has long-acting softness, moisturizing and moist effect.Its chemical constitution includes more than 95% unsaturated LCFA, and carbon chain atom number is more than 20, determines its outstanding lubrication and conditioning performance and outstanding oxidation resistance, it is possible to play good moisturizing effect.
Borage extract: borage is a kind of raw herbaceous plant strong, annual.Showing according to research, it has the pharmacological action of anti-inflammatory and antalgic." borage extract anti-inflammatory and antalgic pharmacology Effect study " literary composition in " Chinese pharmacy conference in 2012 and the 12nd Chinese pharmacists week collection of thesis " is described.It is applied in diaper dermatitis frost, it is possible to there is the effect of anti-inflammatory analgetic so that the anti-inflammatory that the skin of baby can more be accelerated in inflamed sites, and can pain relieving.
Menthanol lactic acid ester: be also called 2 hydroxy propanoic acid-5-methyl-2-isopropyl cyclohexyl), lactic acid ester in the Meng, menthyl lactate, 2 hydroxy propanoic acid-5-methyl-2-isopropyl cyclohexyl, it it is a kind of peppermint derivative, belong to cold-type yellow (clear) product, formula teacher designed cold-type yellow (clear) product and can only use peppermint in the past, did not had other to select.But the volatility of peppermint and excitant are very big, cause cooling effect strong and very brief, cover the smell of essence because having special mint flavored.For the market vacancy, release long-acting tasteless freshener: menthyl lactate, there is slight peppermint fragrance, taste almost without taste, but with lasting, pleasant cooling effect, it is identified as fabulous not having bad reaction such as burning sensation, excitement and the freshener of tingling sensation, is mainly used in daily chemical products, the product such as prepared by medicine, dental products and candy.The skin of baby do not had any stimulation, it is adaptable to various sensitive skins, in the present invention for using as skin condition.
Bisabolol: a kind of composition that bisabolol is present in yellow chamomile, the antiinflammation of yellow chamomile is essentially from bisabolol.For colourless to straw Huang thick liquid, being dissolved in lower alcohol (ethanol, isopropanol), fatty alcohol, glyceride and stone vinegar, almost insoluble in water and glycerine, slight smell own, refraction coefficient is 1.492~1.498.Bisabolol is mainly used in skin sparing and skin care cosmetics, and bisabolol is as active component with protection and nursing allergic skin, and bisabolol is suitable for use in sunscreen product, bath essence after sunbath, baby products and after shaving in nursing product.The stability of bisabolol and well skin-friendliness, it is well suited for being used in cosmetics, and bisabolol preserves for a long time will not variable color, also plastic containers will not be oozed out, using and do not have what problem, bisabolol not only has anti-inflammatory performance, has also been proved to bacteriostatic activity.Showing according to data, bisabolol is safe for cosmetics.Can further reach the nursing efficacy to skin.
Campesterol class: be the plant hormone newly confirmed recent years, is also a class cyclopentanoperhy drophenanthrene, but they is different from the mechanism of action of animal steroid hormone, play a role without nucleus inner recipient, but transmit signal by cell membrane surface receptors.The campesterol class of very low concentrations just can be with induced strong growth and differentiation, it is possible to promote the growth of cell so that heal quicker.
Pot marigold extract: pot marigold extract contains lutein and luteole, and ancient Egyptian thinks that it can delay senility, Indian's then honor is given it and is contained mineral phosphor and vitamin C for holy refreshing flower, pot marigold.Medical experiment proves that natural carotenol contained in plant is the antioxidant of a kind of excellent performance, adding a certain amount of lutein in food can prevent cell ageing and biological organs old and feeble, the visual impairment that senile eyeball retina macular degeneration causes the most also can be prevented with blind, by a series of medical research, carotenoid has been proposed as cancer prevention agent, life extends agent, ulcer inhibitor, heart attack and the inhibitor of coronary artery disease.Introduce pot marigold extract in the present invention, make use of it to delay senility and oxidation resistant effect, smeared to skin surface, it is possible to skin is played further opsonic action.
German chamomile caul-fat: Flos Chrysanthemi i.e. chamomile, its oil is a kind of popular health care and pharmaceutical preparation, effect of helpful sleep, alleviates inflammation and the pain symptom of patient, alleviates the insomnia caused by neurotic skin itch.The effect calmed the nerves can be played so that baby's mental relaxation, eliminate anxiety.
Dehydroactic acid: another name dehydroacetic acid, solid-state is white or light yellow crystalline powder, odorless, tasteless, fusing point 108~110 DEG C, boiling point 270 DEG C, is a kind of low toxicity efficient corrosion resisting, mould inhibitor.Certain antibacterial action is all had under the conditions of acid, alkali, especially the strongest to the inhibitory action of mould.It is added on clearing damp protective cream of the present invention interior for suppressing the growth of bacterium, plays corrosion-resistant effect.
Phenmethylol: phenmethylol is one of simplest aromatic alcohol, another name: benzylalcohol, crude benzene methyl alcohol, benzylalcohol.It is considered as the substituted methyl alcohol of phenyl.In nature, majority is presented in ester in essential oil, such as all contain this composition in jasmin oil, hyacinth oil and peru balsam.Phenmethylol is of many uses in industrial chemical produces.For paint solvent;Photographic developer;PVC stabilizer;Medicine;Synthetic resin solvent;The solvent of vitamin b parenteral solution;Ointment or the preservative of liquid.In clearing damp protective cream of the present invention, phenmethylol and dehydroactic acid are collectively forming a dual anti-corrosion function.
Hydrolysed rice albumen: rice protein is mainly made up of four kinds of albumen such as albumin, globulin, protein,alcohol-soluble and glutelin.Hydrolysed rice albumen, after the protein in rice protein is processed by the hydrolyzable of protein decomposition enzyme, the breaks down proteins elite that allotment obtains.Rich in materials such as amino acid, it is possible to promote that fibrous bud cell produces collagen.It is applied in clearing damp protective cream of the present invention, can be while playing efficient moisture-retention effect, the defensive enginery of strengthening skin, keep the normal angling of horn cell, suppress bacterial reproduction.
Purslane extract: use extraction the low temperature method stem from purslane and leaf to obtain and there is bioactive extract, and be dissolved in certain density butanediol solution.Purslane extract antiallergy usefulness is close with " chamomile extract " and " 10% dipotassium glycyrrhizinate powder ", the flavones simultaneously contained in purslane and saponin have free radical and antioxidation, can be with delay skin aging, there is again the most anti-drying aging, increase skin comfort degree and remove free radical, improving the combination property of skin comfort etc..Being experimentally confirmed, Purslane extract has obvious antipruritic function and pain and redness is had obvious rejection ability.It is added in this clearing damp protective cream, the place of eczema can be occurred effectively to alleviate its itch degree baby, and can inhibition of pain and redness, skin comfort degree can be increased again simultaneously, can also effective antiallergy to a certain extent, it is possible to play good greater skin conditioning efficacy.
Ginger-root extract: being the material that extracts of the root from ginger, its main component includes the peppery alcohol of 6-ginger, 6-shogaol, the peppery alcohol of 8-ginger, the peppery alcohol of 10-ginger.There is enhancing immunity, antibacterial, desinsection, the effect of anti-inflammatory, also there is the strongest oxidation resistance.In traditional medicine circle, it is used for for a long time reducing inflammatory effect.Can play carrying out sterilizing at skin eczema so adding ginger-root extract in clearing damp protective cream of the present invention, reducing the effect of inflammation.
By using technique scheme, in this diaper dermatitis frost, white pond flower seed oil, borage extract, purslane extract, bisabolol, ginger-root extract, pot marigold caul-fat, german chamomile G & W solution rice protein can play a good skin care effect, it is possible to have the effect of good anti-inflammation and sterilization.And various compositions are the most all to extract from natural plants, to human body entirely without side effect, and each composition complements each other, it is possible to play more outstanding antiinflammation.And in diaper dermatitis frost, it is added with menthol lactic acid fat, it is possible to make whole product have a good fragrance, it is possible to allow people smell the most joyful.By being added to vaseline, as the softener of the present invention, the interpolation of Butyrospermum parkii fruit fat is as emollient, and the interpolation of microwax is as adhesive.All the components is worked in coordination, and complements each other thus reaches an effect more preferably, the diaper dermatitis frost that more green natural is non-stimulated to skin.
Detailed description of the invention
Embodiment one:
A kind of diaper dermatitis frost, it is as follows that its internal each composition carries out proportioning by its percent mass: the vaseline of 40%, the water of 30%, Butyrospermum parkii fruit fat, polyglycereol-2 distearate of 1%, the microwax of 1%, the white pond flower seed oil of 0.2%, the borage extract of 0.2%, the menthanol lactic acid ester of 0.3%, the bisabolol of 0.2%, the campesterol class of 0.01%, the pot marigold caul-fat of 0.2%, the german chamomile caul-fat of 0.2%, the dehydroactic acid of 0.08%, the phenmethylol of 0.7%, the hydrolysed rice albumen of 0.4%, the purslane extract of 5% and the ginger-root extract of 0.1% of 20.71%.
Embodiment two:
A kind of diaper dermatitis frost, it is as follows that its internal each composition carries out proportioning by its percent mass: the vaseline of 30%, the water of 40%, the Butyrospermum parkii fruit fat of 20.71%, polyglycereol-2 distearate of 1.5%, the microwax of 0.5%, the white pond flower seed oil of 0.2%, the borage extract of 0.1%, the menthanol lactic acid ester of 0.4%, the bisabolol of 0.2%, the campesterol class of 0.01%, the pot marigold caul-fat of 0.3%, the german chamomile caul-fat of 0.1%, the dehydroactic acid of 0.08%, the phenmethylol of 0.6%, the hydrolysed rice albumen of 0.5%, the purslane extract of 5% and the ginger-root extract of 0.1%.
Embodiment three:
A kind of diaper dermatitis frost, it is as follows that its internal each composition carries out proportioning by its percent mass: the vaseline of 35%, the water of 35%, Butyrospermum parkii fruit fat, polyglycereol-2 distearate of 1%, the microwax of 1%, the white pond flower seed oil of 0.3%, the borage extract of 0.1%, the menthanol lactic acid ester of 0.3%, the bisabolol of 0.3%, the campesterol class of 0.01%, the pot marigold caul-fat of 0.2%, the german chamomile caul-fat of 0.2%, the dehydroactic acid of 0.08%, the phenmethylol of 0.7%, the hydrolysed rice albumen of 0.4%, the purslane extract of 5% and the ginger-root extract of 0.1% of 20.71%.
A kind of method preparing this diaper dermatitis frost, including following step:
S1: water, purslane extract and hydrolysed rice protein mixture are heated to 60 DEG C-80 DEG C and stir so that it is dissolve formation aqueous phase material (preferable temperature here is 70 DEG C) that is uniformly dispersed;
S2: vaseline, Butyrospermum parkii fruit fat, polyglycereol-2 distearate, microwax and Bai Chi flower seed oil mixture are heated to 65 DEG C-80 DEG C and stir so that it is dissolves formation oil phase material (preferable temperature here is 72 DEG C) that is uniformly dispersed;
S3: by aqueous phase material and oil phase material mix and blend, and emulsifying 9-15 minute (the preferred time here is 12 minutes) in the environment of vacuum, be subsequently cooled to 40 DEG C-50 DEG C (preferable temperature here is 45 DEG C), vacuumize;
S4: add the essence preservative including borage extract, menthanol lactic acid ester, bisabolol, ginger-root extract, campesterol class, german chamomile caul-fat, dehydroactic acid and phenmethylol in the product that will prepare in S3, be sufficiently stirred for homogeneous 4 minutes;
S5: the product prepared in S4 is cooled to 25 DEG C-35 DEG C (preferable temperature here is 30 DEG C), discharging;Sampling censorship, after the inspection of semifinished product is qualified, enter filling operation filling, packaging.
The above is the preferred embodiment of the present invention, the most without departing from the principles of the invention, it is also possible to make some modification and improvement, and these also should be regarded as protection scope of the present invention.

Claims (5)

1. a diaper dermatitis frost, is characterized in that: it is mixed by following raw material, calculates by mass percentage, is respectively as follows:
Percentage composition
Vaseline 30-50
Water 20-40
Butyrospermum parkii fruit fat 10-30
Polyglycereol-2 distearate 1-2
Microwax 0.5-1.5
White pond flower seed oil 0.1-0.3
Borage extract 0.1-0.3
Menthanol lactic acid ester 0.1-0.5
Bisabolol 0.1-0.3
Campesterol class 0.005-0.015
Pot marigold caul-fat 0.1-0.3
German chamomile caul-fat 0.1-0.3
Dehydroactic acid 0.03-0.09
Phenmethylol 0.5-0.9.
Diaper dermatitis the most according to claim 1 frost, is characterized in that: further comprises hydrolysed rice albumen, its mass percent is 0.2-0.6.
Diaper dermatitis the most according to claim 2 frost, is characterized in that: further comprises purslane extract, its mass percent is 3-7.
Diaper dermatitis the most according to claim 3 frost, is characterized in that: further comprises ginger-root extract, its mass percent is 0.05-0.15.
5. a preparation method for diaper dermatitis frost, its feature comprises the following steps:
S1: water, purslane extract and hydrolysed rice protein mixture are heated to 60 DEG C-80 DEG C and stir so that it is dissolve the formation aqueous phase material that is uniformly dispersed;
S2: vaseline, Butyrospermum parkii fruit fat, polyglycereol-2 distearate, microwax and Bai Chi flower seed oil mixture are heated to 65 DEG C-80 DEG C and stir so that it is dissolves the formation oil phase material that is uniformly dispersed;
S3: by aqueous phase material and oil phase material mix and blend, and emulsifying 9-15 minute in the environment of vacuum, be subsequently cooled to 40 DEG C-50 DEG C, vacuumize;
S4: add the essence preservative including borage extract, menthanol lactic acid ester, bisabolol, ginger-root extract, campesterol class, german chamomile caul-fat, dehydroactic acid and phenmethylol in the product that will prepare in S3, be sufficiently stirred for homogeneous 4 minutes;
S5: the product prepared in S4 is cooled to 25 DEG C-35 DEG C, discharging;Sampling censorship, after the inspection of semifinished product is qualified, enter filling operation filling, packaging.
CN201510027174.1A 2015-01-20 2015-01-20 A kind of diaper dermatitis frost and preparation method thereof Expired - Fee Related CN105853260B (en)

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CN106265247A (en) * 2016-08-23 2017-01-04 广州君研生物科技有限公司 A kind of multiple-effect maintenance frost preparation method
CN106667844A (en) * 2017-02-06 2017-05-17 周高超 Herbal creamy cleansing lotion
CN108186499A (en) * 2018-03-19 2018-06-22 广州市聚吉科绿色化学共性技术研究院有限公司 A kind of prevention face decortication composition
CN111228166A (en) * 2020-01-10 2020-06-05 广州贝玛生物科技有限公司 Soothing skin cream for infants and preparation method thereof
CN111544564A (en) * 2020-04-29 2020-08-18 娇时日化(杭州)股份有限公司 Ointment for treating infantile diaper dermatitis and preparation method thereof
CN112494377A (en) * 2020-09-22 2021-03-16 福建省梦娇兰日用化学品有限公司 Infant repair cream containing rape-derived phytosterol and preparation method thereof
CN114983880A (en) * 2022-07-21 2022-09-02 福建省梦娇兰日用化学品有限公司 Children moisturizing body lotion and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN106265247A (en) * 2016-08-23 2017-01-04 广州君研生物科技有限公司 A kind of multiple-effect maintenance frost preparation method
CN106265247B (en) * 2016-08-23 2019-04-26 广州君研生物科技有限公司 A kind of multiple-effect maintenance frost preparation method
CN106667844A (en) * 2017-02-06 2017-05-17 周高超 Herbal creamy cleansing lotion
CN108186499A (en) * 2018-03-19 2018-06-22 广州市聚吉科绿色化学共性技术研究院有限公司 A kind of prevention face decortication composition
CN111228166A (en) * 2020-01-10 2020-06-05 广州贝玛生物科技有限公司 Soothing skin cream for infants and preparation method thereof
CN111544564A (en) * 2020-04-29 2020-08-18 娇时日化(杭州)股份有限公司 Ointment for treating infantile diaper dermatitis and preparation method thereof
CN111544564B (en) * 2020-04-29 2023-07-28 娇时日化(杭州)股份有限公司 Ointment for treating infant diaper dermatitis and preparation method thereof
CN112494377A (en) * 2020-09-22 2021-03-16 福建省梦娇兰日用化学品有限公司 Infant repair cream containing rape-derived phytosterol and preparation method thereof
CN114983880A (en) * 2022-07-21 2022-09-02 福建省梦娇兰日用化学品有限公司 Children moisturizing body lotion and preparation method thereof

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