KR102047214B1 - Composition for scalp care and manufacturing method thereof - Google Patents

Abstract

The present invention provides a composition for scalp care, comprising 0.1 to 1 parts by weight of Glycine soja germ extract, 0.05 to 0.15 parts by weight of Scutellaria baicalensis root extract, 0.1 to 1 parts by weight of Triticum vulgare germ extract, 0.05 to 0.15 parts by weight of Saccharomyces cerevisiae extract, 0.1 to 1 parts by weight of sodium surfactin, 0.1 to 1 parts by weight of 4-terpineol and the remainder of a solvent. The composition of the present invention minimizes skin irritation.

Description

Composition for scalp care and manufacturing method thereof

The present invention relates to a composition for treating the scalp and a method of manufacturing the same.

Scalp refers to the skin covering the head area. Skin, Connective tissue, Narrow tendon (Aponeurosis), Loose connective tissue, Head bone membrane (Pericranium) It is composed of layers and an important structure is hair. In addition, the scalp is a skin covering the hair and the hair is located in a cosmetic role to protect from ultraviolet rays, heat, cold and external shocks, and to play a functional role in sensory acceptance and temperature control.

Human hair has about 100,000 to 150,000 hairs, and each hair has a different cycle and grows and drops out through the anagen, the catagen, and the telogen. This cycle is repeated over three to six years, with the result that on average 50 to 100 hairs fall out normally on a daily basis.

Unlike in the past, the number of people suffering from abnormal symptoms of scalp and hair is increasing due to changes in diet and stress due to social environment. Increasingly, women's scalp and hair abnormalities are on the rise.

In addition, the mechanism of hair loss is not yet known precisely, but is generally caused by unbalanced diet, excessive drinking and smoking, drug use, lack of sleep, excessive stress, childbirth, menopausal disorders, frequent perm and pigmentation, and hormone imbalance. Known. Human hair grows and grows and falls out of the human hair repeatedly to maintain a constant density.However, when the hair loss progresses due to the above causes, the hair on the crown or forehead starts to thin and loses strength. The number will increase.

In other words, hair is rooted in the scalp and supplied with nutrients from the blood. When the capillaries shrink and the scalp becomes thin for a long time, the hair becomes incapable of developing normally. This shortened, shortened life of the hair is not only easy to fall out, but also in the hair follicles as described above, the hair does not come out again and eventually the symptoms of hair loss.

Accordingly, research has been conducted on compositions that can prevent abnormal symptoms of the scalp and hair and improve the condition of the scalp and hair. However, existing scalp and hair-related products often have chemicals that are effective in their effects. In many cases, long-term use caused side effects such as irritation of the scalp.

The problem to be solved by the present invention does not use artificial chemicals, environmentally friendly and not harmful to the human body, effectively prevent the abnormal symptoms of the scalp and hair, and further improve the storage stability, which is a problem of the composition containing a natural-derived extract It is to provide a composition for managing the scalp that can be secured.

In order to solve the above problems, the present invention is 0.1 to 1 parts by weight of stone bean embryo extract, 0.05 to 0.15 parts by weight of golden extract, 0.1 to 1 parts by weight of wheat germ extract, 0.05 to 0.15 parts by weight of brewer's yeast extract, 0.1 to 1 weight of cactin salt It provides a composition for managing the scalp, comprising 0.1 to 1 part by weight of 4-terpineol, and the remainder of the solvent.

Furthermore, the present invention provides a step of preparing a first composition comprising a stone bean germ extract, a golden extract, wheat germ extract and a first solvent, preparing a second composition comprising a brewer's yeast extract and a second solvent, a surfactin compound It provides a method for producing a scalp care composition comprising the step of preparing a third composition comprising a 4-terpineol and a third solvent, and mixing the first to third compositions.

The scalp care composition according to the present invention is a natural-derived material that minimizes skin irritation and forms hair follicles and healthy hair roots with minimal moisturizing and impurities of the scalp, thereby preventing hair loss and exerting an excellent hair growth effect. Storage stability and stability over time can be secured.

Hereinafter, various embodiments of the present invention are described. It is to be understood that the present invention is not limited to specific embodiments, and includes various Modifications, Equivalents, and / or Alternatives of the embodiments of the present invention. In connection with the description of the drawings, similar reference numerals may be used for similar components.

In this document, expressions such as "have", "may have", "include", or "may contain" include the presence of a corresponding feature (e.g., numerical, functional, operational, or component such as a component). Does not exclude the presence of additional features.

In this document, expressions such as "A or B", "at least one of A or / and B", or "one or more of A or / and B" may include all possible combinations of items listed together. . For example, "A or B", "at least one of A and B", or "at least one of A or B" includes (1) at least one A, (2) at least one B, Or (3) both of cases including at least one A and at least one B.

The expression "Configured to" used in this document is, for example, "Suitable for", "Having the capacity to" depending on the situation. It may be used interchangeably with "," Designed to "," Adapted to "," Made to ", or" Capable of ". The term "configured to" does not necessarily mean "specifically designed to".

The terminology used herein is for the purpose of describing particular embodiments only and may not be intended to limit the scope of other embodiments. Singular expressions may include plural expressions unless the context clearly indicates otherwise. The terms used herein, including technical or scientific terms, may have the same meaning as commonly understood by one of ordinary skill in the art. Among the terms used in this document, terms defined in the general dictionary may be interpreted as having the same or similar meaning as the meaning in the context of the related art, and unless it is clearly defined in this document, in an ideal or excessively formal meaning. Not interpreted. In some cases, even if terms are defined in the specification, they may not be interpreted to exclude embodiments of the present disclosure.

In addition, each step of the process according to the present invention is not limited to that by a complete time series order, but the invention is easily described according to the order applied to the manufacturing process of a general composition, and the process order of the invention is necessary. It is possible to change or modify according to the course, the preparation of the compositions described below may be carried out separately in a separate process.

The embodiments disclosed herein are presented for the purpose of explanation and understanding of the disclosed, technical details, and do not limit the scope of the invention. Therefore, the scope of the present document should be construed as including all changes or various other embodiments based on the technical idea of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail. Prior to this, terms or words used in the present specification and claims should not be construed as being limited to the common or dictionary meanings, and the inventors should properly explain the concept of terms in order to best explain their own invention. Based on the principle that can be defined, it should be interpreted as meaning and concept corresponding to the technical idea of the present invention.

Therefore, the configuration of the embodiments described herein are only some of the most preferred embodiments of the present invention and do not represent all of the technical idea of the present invention, various equivalents and modifications that may be substituted for them at the time of the present application It should be understood that there may be

Throughout the specification, when a part is said to "include" a certain component, it means that it may further include other components, except to exclude other components unless otherwise stated.

Scalp Care Composition

Composition for managing the scalp according to an embodiment of the present invention is 0.1 to 1 parts by weight of Glycine Soja Germ Extract, 0.05 to 0.15 parts by weight of Golden Extract (Scutellaria Baicalensis Root Extract), wheat germ extract (Triticum Vulgare Germ Extract) ) 0.1 to 1 parts by weight, brewer's yeast extract (Saccharomyces Cerevisiae Extract) 0.05 to 0.15 parts by weight, 0.1 to 1 parts by weight of the serpentine salt, 0.1 to 1 parts by weight of 4-terpineol (4-Terpineol) and the remainder of the solvent It may be.

The content of the composition described herein is based on 0.1 to 1 parts by weight of the stone bean germ extract, the weight part of the remaining components means a relative content ratio according to the weight part of the stone bean germ extract.

The dol bean germ extract is derived from dol bean, dol bean is botanically, a yearly vine-like vines belonging to the legume (Leguminosae), also called Ya soybean (野 大豆), Yayodu (野 料 豆) . Length 2m. It is brown hair facing downward, petiole long, 3 leaflets, small leaves and short hairs. Flowers are light purple, gunshot inflorescence, length is 2-5cm, stamen is 10, divided into 2 each, and fruit is 2-3cm, hairy, similar to pod of beans. Seeds are a little flat and resemble small beans.

Dol-bean germ extracts obtained from such dol-bean embryos contain lysophospholipid, and unlike phospholipids having double-stranded fatty acids, lysophospholipids have a single-stranded fatty acid, so that the stability of the composition at acidic or high temperature is low. great. In addition, the stone bean germ extract may contain a large amount of carbohydrates, proteins, fats and may act as a main source of nutrient supply of the scalp.

In the scalp care composition of the present invention, the stone germ extract may include 0.1 to 1 part by weight, and if included in less than the above range, the supply of nutrients to the scalp is insignificant, and if included in excess of the above range, It is not preferable in terms of storage stability as it contains the extract.

The golden extract means golden, a perennial herb belonging to the Lamiaceae (Labiatae), and in particular, may mean dry by peeling the golden root, but is not limited to the root, stem, mouth, flowers or seeds of golden. . Traditionally, gold has been used for the treatment of high blood pressure and epidemic meningitis due to dehumidification fever and hemostasis. The present inventors have found that when these golden extracts are used in the scalp care composition, they are effective for antibacterial, anti-inflammatory and anti-allergy of the scalp. In addition, gold can keep the scalp healthy by relieving itching and scalp problems of the scalp and inhibiting the activity of dandruff.

In the scalp care composition of the present invention, the golden extract may include 0.05 to 0.15 parts by weight, and if it is included below the range, the antimicrobial, anti-inflammatory and anti-allergic effects of the scalp are insignificant and included in excess of the above range. It is not preferable in terms of storage stability because it contains an excessive amount of natural extract.

The wheat germ extract is a nutrient-rich embryo of wheat kernels (wheat kernel) that is removed in the process of processing whole wheat flour, accounting for about 2-3% of the whole wheat grains. Wheat germ, which is a seed of wheat, is known to be rich in vitamin E (tocopherol), which has been known as an antioxidant vitamin to date. According to a recent study, natural substances extracted from wheat germ are known to restore the damaged immune function of the human body. Contains carbohydrates, proteins, and fats, which can act as a major source of nutrient supply to the scalp.

In the composition for care of the scalp of the present invention, the wheat germ extract may include 0.1 to 1 parts by weight, and if it is included below the range, the nutrient supply is insignificant, and if it exceeds the range, the excess natural extract is stored. It is not preferable in terms of stability.

The brewer's yeast extract, also called baker's yeast, is used in the manufacture of beer brewers' yeast, alcoholic beverages and bread. Brewer's yeast is one of the yeasts needed to make beer. The fermentation of wort is completed in the beer manufacturing process, and the yeast in Saccharomyces, which is separated after filtering beer, is non-fermentable, contains about 45% protein, and contains high levels of vitamin B and phosphorus. In addition, the strain produces a high concentration of ethanol and has the characteristics to withstand high concentrations of ethanol. Brewer's yeast contains large amounts of protein, nucleic acid, carbohydrates, minerals and vitamins. In particular, vitamin B contained in a large amount of brewer's yeast extract is effective for improving the condition of hair and maintaining the health of the scalp.

In the composition for managing the scalp of the present invention, the brewer's yeast extract may include 0.05 to 0.15 parts by weight, and if it is included in the range below the nutrient supply is insignificant, and if included in excess of the range, the balance between the natural extract is inadequate Rather, it may not secure the inherent effects of the composition of the present invention.

The cactin salt is an amphipathic substance derived from living organisms as a biosurfactant. Such a biosurfactant is a natural substance, biodegradable compared to a synthetic surfactant, and is low in toxicity, harmless to the human body, and has the effect of maintaining activity even under extreme conditions.

The cactin salt can be used as an inorganic salt or an organic salt. Specifically, it may include a salt containing at least one selected from the group consisting of sodium, potassium, lithium, triethanolamine, lysine, arginine and choline as a counter ion.

According to the present invention, it is preferable to form 4-terpineol and core-shell fine particles described later, and to use sodium cactin in order to secure storage stability and stability over time of the scalp management composition.

In the scalp care composition of the present invention, the surfactin salt may include 0.1 to 1 part by weight, and if it is included below the range, the storage stability and the seizure stability over time are insignificant, and the salt is included in excess of the range. The stability may be impaired when applied to the formulation.

The 4-terpineol is a monoterpene compound, Cas No. is 562-74-3, a structural formula is C ₁₀ H ₁₈ O, and a molecular weight is 154.25 g / mol. The structure is shown in the following formula (1).

[Formula 1]

The 4-terpineol is a component contained in tea tree essential oil, which is caused by various bacteria or fungi, and has an effect on treating inflammation, and has excellent sterilization and disinfection, so that small wounds, abrasions, purulent acne or rashes, It is known to prevent infections such as viral infections and insect bites.

The inventors of the present invention, when combined with the serpentine salt, when forming a composition, can exhibit an antiseptic effect on the basis of excellent antibacterial and bactericidal power can ensure the storage stability of the composition.

In addition, it can be confirmed that the effect is also effective in moisturizing the scalp, scalp elasticity or erythema suppression effect.

Therefore, in the composition for scalp management of the present invention, the terpineol may include 0.1 to 1 part by weight, and if included in the range below the storage stability and securing stability over time is insignificant and included in excess of the range The increased alcohol content can irritate the scalp.

In the scalp care composition of the present invention, the weight ratio of the sodium cactin and 4-terpineol is preferably 1: 1.5 to 0.5, and more preferably 1: 1.1 to 0.9.

In case of using a natural-derived extract as a composition, it may cause relatively little side effects to the human body due to its low chemical hazard, but since a component is formed from organic substances derived from a natural substance, after a certain time, the component may be deteriorated or denatured. And corruption may occur.

In particular, in the case of the stone bean germ extract, golden extract, wheat germ extract and brewer's yeast extract of the present invention, as an essential component in scalp management, it was confirmed that the chemical and physical stability can be secured when mixed, For the reasons as described above, there are insignificant points in terms of securing storage stability.

Therefore, by limiting the weight ratio of the sodium surfactin and 4-terpineol within the above range, it is possible to ensure the storage stability of the finally formed scalp management composition.

Furthermore, due to the characteristics of the scalp management composition, in which different components are mixed with each other while exhibiting different action effects, when the final composition is stored in a container after completion of a long time, layer separation may occur. This may occur irrespective of the deterioration of the composition itself, but is a factor that may cause a rejection in the visual element to the user using the composition.

Accordingly, the present invention can ensure the stability over time by minimizing the layer separation phenomenon as described above, including the core-shell-type fine particles formed of a shell containing sodium surfactin and a core containing 4-terpineol.

The above-described core-shell fine particles are derived from the oil-terminated 4-terpineol, while the hydrophilic and lipophilic components distributed in the scalp care composition are separated through the sodium cactin of the surfactant component so as not to have an opaque appearance. By forming the micelle to form a 4-terpineol inside the micelles so that the delamination does not occur, it is possible to induce a delamination even if the composition is subjected to a long period of time. In addition, 4-terpineol having a relatively low boiling point can be stably included in the composition through the core-shell type fine particles, thereby further securing storage stability at high temperature of the final composition. In addition, it is possible to improve the stability of the product over time by inhibiting the phenomena generated by combining the above-mentioned constituents stone extract, golden extract, wheat germ extract and brewer's yeast extract with impurities remaining in the scalp care composition.

In the scalp care composition of the present invention, the formulation of the scalp care composition is not particularly limited as long as it can exert the effects of the present invention. For example, solubilizers such as tonics, emulsifiers such as emulsions, creams, ointments, Any formulation of external preparations for skin, such as dispersions, gels, aerosols, mousses and the like, can be taken. In addition, the form of the product is a hair care medicine, quasi-drug or cosmetics for the purpose of preventing hair loss, hair growth, hair growth, wool, etc., for example, hair growth accelerator, hair growth agent, scalp treatment agent, soap, It can take any form, such as a skin external preparation or a skin cleanser, such as a hair tonic, a shampoo, a rinse, a hair pack, a lotion, a conditioner, a hair oil, a mousse, and a cream. In addition, the composition of the present invention can be used in the form of solids, solutions, emulsions, dispersants, micelles, liposomes, ointments.

In the cosmetic composition of the present invention, additives other than the active ingredient are not particularly limited and can be used without limitation. For example, when the composition is used for medical purposes, a pharmaceutically acceptable conventional carrier may be included, and when applied to cosmetics, pharmacologically acceptable additives in the cosmetic field may be used without limitation. In the scalp care composition of the present invention, the scalp care composition includes a surfactant, an emulsifier, a soap acid, a solvent, a binder, a diluent, a lubricant, a stabilizer, a pharmaceutical, a lower alcohol, a thickener, a chelating agent, a coloring agent, a preservative, and a coloring agent. , Preservatives, antibiotics, antioxidants, antifoams, antibacterial agents, antidepressants, enzymes, plant or mineral oils, fats, fluorescent substances, fungicides, combustibles, humectants, fragrances, fragrance carriers, preservatives, proteins, silicones, solubilizers It may contain one or two or more pharmacologically acceptable excipients selected from the group consisting of sugar derivatives, sunscreens, vitamins, plant extracts and waxes.

In the case of water used as a solvent of the scalp care composition, purified water and ultrapure purified water which are commonly used in the art may be used, and ultrapure purified water may be preferably used. General purified water is a water generally used in pharmaceuticals, cosmetics, etc., the dissolved solids exhibiting purity of 1.0 to 0.5ppm, the size of the filter used to remove particulates and microorganisms in the preparation of purified water is 0.2 to 0.45㎛, pH is It varies from weak acid to weak alkali. The ultra-pure purified water has a high purity of 0.03ppm dissolved solids, the size of the filter used in the production of ultra-pure purified water is 0.001㎛ removed 99.99% microorganisms by using this, pH is neutral, so it is preferable for the composition for scalp management. . In particular, ultrapure purified water not only prevents automatic oxidation of the composition by removing metal ions, but also prevents protein aggregation due to metal ions, so that the formulation can be applied evenly to the scalp while being hypoallergenic.

Method of producing a composition for scalp care

The composition for managing the scalp according to an embodiment of the present invention may be prepared in a one-component type, unless there is a special situation, but preferably, the preparation may be carried out through the following manufacturing method to ensure formulation retention and storage stability. .

Specifically, preparing a first composition comprising a stone bean germ extract, a golden extract, wheat germ extract and a first solvent, preparing a second composition comprising a beer yeast extract and a second solvent, surfactin compound, 4 -Preparing a third composition comprising terpineol and a third solvent and mixing the first to third compositions.

The step of preparing the first composition, 0.1 to 1 parts by weight of the stone bean embryo extract, 0.05 to 0.15 parts by weight of the golden extract based on 0.1 to 1 parts by weight of the stone beans germ extract, wheat based on 0.1 to 1 parts by weight of the stone beans germ extract Embryonic extract may be prepared to include 0.1 to 1 parts by weight and the remainder of the first solvent.

As the first solvent, purified water or ultrapure purified water, which are commonly used in the art, may be used, and ultrapure purified water may be preferably used. General purified water is a water generally used in pharmaceuticals, cosmetics, etc., the dissolved solids exhibiting purity of 1.0 to 0.5ppm, the size of the filter used to remove particulates and microorganisms in the preparation of purified water is 0.2 to 0.45㎛, pH is It varies from weak acid to weak alkali. The ultra-pure purified water has a high purity of 0.03ppm dissolved solids, the size of the filter used in the production of ultra-pure purified water is 0.001㎛ removed 99.99% microorganisms by using this, pH is neutral, so it is preferable for the composition for scalp management. . In particular, ultrapure purified water not only prevents automatic oxidation of the composition by removing metal ions, but also prevents protein aggregation due to metal ions, so that the formulation can be applied evenly to the scalp while being hypoallergenic.

The preparing of the second composition may include preparing 0.05 to 0.15 parts by weight of the brewer's yeast extract and a remainder of the second solvent, based on 0.1 to 1 parts by weight of the dol bean germ extract, wherein the second solvent is described above. The same thing as one 1st solvent can be used.

The preparing of the third composition may include 0.1 to 1 parts by weight of cactin salt, based on 0.1 to 1 parts by weight of the soybean embryo extract, and 0.1 to 1 parts by weight of 4-terpineol based on 0.1 to 1 parts by weight of the stone bean embryo extract. And it may be to include a residual solvent, the third solvent is preferably to use a polyhydric alcohol compound for the formation of easy core-shell fine particles.

The polyhydric alcohol compound is specifically ethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, diethylene glycol, sorbitol, mannitol, maltitol, lactitol, glucose, polyethylene glycol, butylene glycol and polypropylene glycol It may include one or more selected from, and for the storage stability of the final composition, it is preferable to use butylene glycol.

According to one embodiment of the present invention, further comprising the step of forming a core-shell-like fine particles formed of a shell comprising sodium surfactin and a core comprising 4-terpineol in the mixing of the third composition Can be.

Specifically, the core-shell fine particles may be in the form of 4-terpineol present in the sodium surfactin of the Michel form.

In order to form these fine particles, after mixing sodium surfactin with butylene glycol as a third solvent at room temperature, the mixture is heated up to 40 ° C. Thereafter, 4-terpineol is added to the mixture in a weight ratio of 1: 1.5 to 0.5 with respect to the weight of the sodium surfactin. Thereafter, the mixture is cooled to room temperature. In the mixture, the sodium cactin enters a critical concentration to form a micelle, and since 4-terpineol is lipophilic, it is incorporated into the micelle of the sodium cactin to form core-shell fine particles. .

Finally, the composition for managing the scalp of the present invention may include mixing the first to third compositions, and specifically, mixing the first composition and the second composition in a weight ratio of 1: 0.1 to 0.3. It may be. Mixing the first and second compositions in the above weight ratio is preferable in view of moisturizing the scalp and securing hair follicle cell proliferation ability.

EXAMPLE

Hereinafter, although an Example of the additive composition which concerns on embodiment of this invention is described and this invention is demonstrated concretely, this invention is not limited to these Examples.

Preparation of Examples and Comparative Compositions

To prepare a composition for managing the scalp to the components and contents as shown in Tables 1 to 3.

Examples 2 to 3 prepared core-shell-type fine particles formed of a shell containing sodium surfactin and a core containing 4-terpineol, in the following manner, and in the case of the remaining examples and comparative examples, in a one-part form. It was prepared by mixing without going through a separate step.

As a first composition, it was prepared by mixing as much as the content of Table 1 in the ultra-pure purified water, dol bean embryo extract, golden extract, wheat germ extract.

As a second composition, it was prepared by mixing the brewer's yeast extract in ultrapure purified water as shown in Table 1 below.

After mixing sodium surfactin with butylene glycol as a 3rd composition at normal temperature, a mixture is heated up at 40 degreeC. Thereafter, 4-terpineol is added to the mixture in the weight ratio of Table 1 to the weight of the sodium surfactin. Thereafter, the mixture is cooled to room temperature. In the mixture, the sodium cactin enters a critical concentration to form a micelle, wherein the 4-terpineol is incorporated into the micelle of the sodium cactin to form core-shell fine particles. The formation of the fine particles was confirmed by electron microscopy.

Thereafter, the first to third compositions were mixed to finally prepare a composition of Table 2 below.

Ingredient (g) Example 1 Example 2 Example 3 Example 4 Example 5 Purified Water to 100 (g) Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Stone Bean Embryo Extract 0.3 0.4 0.6 0.7 0.5 Golden extract 0.1 0.1 0.1 0.1 0.1 Wheat germ extract 0.6 0.5 0.3 0.2 0.4 Brewer's Yeast Extract 0.1 0.1 0.1 0.1 0.1 Sodium Surfactin 0.5 0.5 0.4 0.6 0.6 4-terpineol 0.45 0.55 0.4 0.2 1.0 Butylene glycol 50 50 50 50 50

Ingredient (g) Example 6 Example 7 Example 8 Comparative Example 1 Comparative Example 2 Purified Water to 100 (g) Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Stone Bean Embryo Extract 0.3 0.4 0.4 0.4 0.4 Golden extract 0.1 0.1 0.1 0.1 0.1 Wheat germ extract 0.6 0.5 0.5 0.5 0.5 Brewer's Yeast Extract 0.05 0.4 0.1 - 0.1 Sodium Surfactin 0.5 0.5 - 0.5 0.5 Calcium Surfactin - - 0.5 - - 4-terpineol 0.45 0.45 0.55 0.55 1.5 Butylene glycol 50 50 50 50 50

Ingredient (g) Comparative Example 3 Comparative Example 4 Purified Water to 100 (g) Remaining amount Remaining amount Stone Bean Embryo Extract 0.4 0.4 Golden extract 0.1 0.1 Wheat germ extract 0.5 0.5 Brewer's Yeast Extract 0.1 0.4 Sodium Surfactin - 0.5 4-terpineol 0.55 - Butylene glycol 50 50

Ingredient (g) Comparative Example 5 Purified Water to 100 (g) Remaining amount Rooibos extract 1.6 Ginseng Root Extract 1.4 Cypress extract 1.4 Sewage Root Extract 1.4 Asterisk Extract 1.4 Peony Root Extract 1.4 Honey extract 1.4 Butylene glycol 40

Experimental Example 1: Moisturizing Effect Test

Samples were prepared by preparing the compositions prepared in Examples and Comparative Examples, respectively, in a solution of 0.3% by weight of xanthan gum. Skin moisturizing effect was measured using transepidermal water loss (TEWL) using an evaporimeter. After washing the subject's scalp, TEWL was measured immediately, and the samples obtained from the above Examples and Comparative Examples were applied to the crown portion of the scalp, and after 4 hours, re-measured to improve the percentage of loss of scalp moisture. The results are shown in Table 5 below.

division Scalp moisture loss improvement rate (%) Example 1 24.1 Example 2 24.0 Example 3 25.1 Example 4 20.2 Example 5 25.5 Example 6 15.2 Example 7 17.0 Example 8 23.8 Comparative Example 1 15.0 Comparative Example 2 18.4 Comparative Example 3 17.3 Comparative Example 4 18.0 Comparative Example 5 20.1

Experimental Example 2: Hair follicle dermal papilla cell proliferation effect

The keratin proteins that make up hair are produced in hair root keratinocytes, which are differentiated from dermal papilla cells. In order to evaluate the activity of the dermal papilla cells of the composition, a rat immortalized dermal papilla cell (DP6) cell line was used in the present invention (Wendy Filsell, Journal of Cell Science 107, 1761-1772 (1994)). This dermal papilla cell line was cultured by microdissection from the hair roots of male PVG rat whiskers and cultured with DMEM (Dulbecco's modified Eagle's medium, Gibco BRL, Gaithersburg, MD, USA) was incubated for 24 hours in an incubator maintained at 5% CO2, 37 ℃. DP6 was placed in a 96 well plate and incubated in a 37 ° C. incubator for 24 hours, followed by injection of the compositions of the Examples and Comparative Examples. After 24 hours of drug treatment, cell proliferation was measured using the WST-1 kit (Roche). The results are shown in Table 6 below.

division Cell proliferation (%) Example 1 113.1 Example 2 113.0 Example 3 111.9 Example 4 111.5 Example 5 109.2 Example 6 104.9 Example 7 105.2 Example 8 112.9 Comparative Example 1 102.0 Comparative Example 2 103.9 Comparative Example 3 107.1 Comparative Example 4 106.9 Comparative Example 5 108.0 Subtreatment Control (No Composition Injection) 100

Experimental Example 3: Observation of Storage Stability after Preparation

The storage stability of the compositions prepared in Examples and Comparative Examples was evaluated and evaluated. Storage stability was measured by the number of aerobic viable bacteria (bacteria and fungi) according to the bioburden test method of the Ministry of Food and Drug Safety cosmetic safety management standards. The results are shown in Table 7.

division Bacterial count (cfu) Fungal water (cfu) Example 1 Not detected Not detected Example 2 Not detected Not detected Example 3 Not detected Not detected Example 4 Not detected 10 Example 5 Not detected Not detected Example 6 Not detected 20 Example 7 Not detected Not detected Example 8 10 10 Comparative Example 1 Not detected Not detected Comparative Example 2 Not detected Not detected Comparative Example 3 Not detected Not detected Comparative Example 4 20 100 Comparative Example 5 10 20

Experimental Example 4: Observation of stability over time after preparation

The compositions prepared in Examples and Comparative Examples were placed for at least 12 months at room temperature, at least 1 month at high temperature of 45 ° C., and at least 1 month at low temperature of −4 ° C., and observed stability over time. The results are shown in Tables 8 and 9.

○: Good (no change in appearance, transparent), △: change (appearance is opaque), ×: poor (layer separation occurs)

Test items and
Condition Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 25 ℃ 12 months ○ ○ ○ △ ○ ○ -4 ℃ 1 month ○ ○ ○ ○ △ ○ 40 ℃ 1 month △ ○ ○ △ △ △

Test items and
Condition Example 7 Example 8 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 25 ℃ 12 months ○ △ ○ Х Х Х △ -4 ℃ 1 month ○ △ △ △ △ △ △ 40 ℃ 1 month △ △ △ Х Х Х △

Claims (7)

Stone bean embryo extract 0.1 to 1 part by weight,
0.05 to 0.15 parts by weight of golden extract,
Wheat germ extract 0.1-1 part by weight,
Brewer's yeast extract 0.05 to 0.15 parts by weight,
Surfactin salt 0.1 to 1 part by weight,
0.1- 1 part by weight of 4-terpineol and the remainder of the solvent,
The serpentine salt is sodium serpentine, the composition is a composition for managing the scalp comprising a core-shell-type fine particles formed of a shell comprising sodium surftin and a core comprising 4-terpineol.
The method according to claim 1,
The weight ratio of the sodium cactin and 4-terpineol is 1: 1.5 to 0.5 composition for managing the scalp.
Preparing a first composition comprising a stone bean germ extract, a golden extract, a wheat germ extract, and a first solvent,
Preparing a second composition comprising a brewer's yeast extract and a second solvent,
Preparing a third composition comprising a surfactin-based compound, 4-terpineol and a third solvent, and
Mixing the first to third compositions,
The surfactin-based compound is sodium surftin, and the mixing of the third composition includes forming a core-shell-like fine particle formed of a shell including sodium surftin and a core including 4-terpineol. Method of producing a composition for care.
The method according to claim 3,
The first composition and the second composition is a method for producing a composition for managing the scalp is mixed in a weight ratio of 1: 0.1 to 0.3.

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