KR20100093223A - Cosmetic composition containing an extract of ophiopogon japonicus for skin miosture - Google Patents

Abstract

The present invention relates to a cosmetic composition for moisturizing skin containing leaflet vegetation extract, and more specifically, leaflet vegetation extract is a protein that forms a tight junction of the epidermal layer, Claudins-1 and zonula. It promotes the synthesis of zonula occuluden-1 (ZO-1), prevents water loss and increases the moisturizing factor of the stratum corneum by increasing its natural moisturizing factor (NMF) content.

Description

Cosmetic composition for moisturizing skin containing leaflet vegetation extract {Cosmetic composition containing an Extract of Ophiopogon japonicus for Skin Miosture}

The present invention relates to a cosmetic composition for moisturizing skin containing leaflet vegetation extract, and more specifically, leaflet vegetation extract is a protein that forms a tight junction of the epidermal layer, Claudins-1 and zonula. It promotes the synthesis of zonula occuluden-1 (ZO-1), prevents water loss and increases the moisturizing factor of the stratum corneum by increasing its natural moisturizing factor (NMF) content.

In the human body, the skin acts as a protective film to protect the living body from the external environment. It prevents the loss of biological components such as water or electrolytes and prevents harmful substances from entering the body. . Such skin is largely divided into epidermal layer, dermis layer and subcutaneous fat layer. The epidermal layer is composed of keratinocytes and melanocytes. Since the keratinocyte layer on the outermost surface of the skin is in direct contact with the external environment, strong resistance to physical, chemical, or permeation of substances is required, and moisture is lost from the human body to the outside. In addition, it must maintain flexibility by retaining adequate moisture on its own.

Generally, the moisture content of the skin is about 70% in the dermal layer, but decreases gradually toward the epidermal layer, which is about 10 to 30% in the keratinocyte layer. The water supplied from the dermal layer is mainly moved up the stratum corneum by passive diffusion and finally discharged to the outside. This is called trans epidermal water loss (TEWL), which is known to be maintained at an appropriate level by the sebaceous component and the epidermal lipid, which are lipid membrane components of the keratinocyte layer. In addition, a substance having a hydrophilic water retention capability called a natural moisturizing factor (NMF) exists in the keratinocyte layer and is known to play an important role in moisturizing the skin. When the moisture of the keratinocyte layer is maintained at about 10 to 30%, the skin is smooth and soft, and the body protects normally. However, when the moisture content of the keratinocyte layer is less than 10%, the skin becomes rough and the body loses its protective function, causing aging. For example, in the case of dry skin, the cohesion of keratinocytes is weakened, and the scale phenomenon in which keratinocytes are peeled off from the surface of the skin like scales appears. This is because it is less than normal skin. In addition, even healthy skin may suffer from a lack of moisture due to harsh external environment, ie, wind, cold weather, sunlight, face wash, shaving, and the like, and thus worsens the skin condition. Therefore, it is very important to properly maintain the water content of the keratinocyte layer of the skin.

To this end, cosmetics such as sebum-like components, NMF components, or moisturizers such as polyols were added and used. For example, glycerin, sorbitol, etc., which have three or more hydroxyl groups (OH groups) as water-soluble polyols, have been added, but they exhibit excellent moisturizing power, but are sticky, causing unpleasant feelings and depriving moisture in the skin according to relative humidity. In addition, propylene glycol, 1,3-butylene glycol, etc. having two hydroxyl groups (OH groups) may cause side effects of the skin upon addition. In addition, additives such as sodium pyrrolidone carboxylate (PCA-Na), sodium lactate, and urea, which are other natural moisturizing factors, are highly electrolytic and have a problem of impairing the emulsion stability of cosmetics.Amino acids, collagen, elastin The back has moisturizing ability, but its moisturizing ability is limited.

On the other hand, Japanese Patent No. 2000-212020 discloses a technique for solving the above problems by containing a branched fatty acid cholesterol ester, hydrogenated lecithin, and dialkyl ether. However, cholesterol derivatives have a problem in solubility, and when used in a large amount, heaviness and stickiness appear, resulting in decreased feeling of use.

Therefore, the technical problem to be achieved by the present invention is to solve the above problems to provide a skin moisturizing cosmetic composition having no skin irritation and excellent moisturizing effect.

Therefore, it is an object of the present invention to provide a cosmetic composition for moisturizing the skin comprising the leaflet vegetation extract as an active ingredient.

In order to solve the above problems, the skin moisturizing cosmetic composition according to the present invention may include the following means.

According to one embodiment of the present invention, the skin moisturizing cosmetic composition according to the present invention contains lobular vegetation extract as an active ingredient.

According to another embodiment of the present invention, in the skin moisturizing cosmetic composition according to the present invention, the leaflet vegetation extract is characterized in that it is contained in 0.001 ~ 20.0% by weight relative to the total weight of the cosmetic composition.

According to another embodiment of the present invention, in the skin moisturizing cosmetic composition according to the present invention, the leaflet pulsatile extract is i) promoting the synthesis of Claudins-1 and Zonula occuluden-1 (ZO-1), ii) filaggrin Promoting synthesis or iii) increasing NMF and combinations thereof.

According to another embodiment of the present invention, in the skin moisturizing cosmetic composition according to the present invention, the cosmetic composition is characterized in that it has a formulation of a lotion, essence, lotion, cream, pack, gel, ointment, patch, or spray. do.

In the present invention, the leaflet vegetation extract contains leaflet vegetation extract, and the leaflet vegetation extract promotes the synthesis of claudins-1 and zonula occuluden-1 (ZO-1) in the epidermal layer. It provides a cosmetic composition for moisturizing the skin to improve the moisturizing power of the stratum corneum by helping to form a junction () to prevent moisture loss and increase the natural moisturizing factor (NMF) content of the stratum corneum.

Hereinafter, the present invention will be described in detail.

The present invention provides a cosmetic composition to improve the moisturizing ability of the stratum corneum by containing the leaflet vegetation extract to help the formation of a tight junction to prevent moisture loss and increase the natural moisturizing factor (NMF) content of the stratum corneum.

The present inventors conducted a study to search for substances having excellent moisturizing effect on native plants and animals, and confirmed that the moisturizing effect of the lobular vegetation extract was excellent and completed the present invention.

The lobular vegetation used in the present invention (Ophiopogon japonicus, 小葉 다) is a perennial herbaceous plant belonging to the genus Liliaceae, which is called the "leaflet" because it has a particularly small and thin leaf compared to the common Liriope platyphylla . do. It grows mainly in the shade of mountains. Root stems grow to the side, and the roots are thickened like peanuts. The leaves are clustered from the bottom, linear, and butterflies 2-4 mm. Flowers blossom in May, light purple or white, with about 10 shots. The edges are membranous (膜質: translucent like thin paper), and one or two flies between the basofoams. A stalk is 7-12cm long, flat and with sharp ridges. Small flower stalks have a node in the middle or below the flower. Petals and stamens are 6 pieces each. Anther is basso but fruit is round and dark sky blue. The tuber root is used as medicinal oil as Macmundong. It is distributed in Korea, Japan, China and Taiwan. Neon Bone Carbide is known to have the effect of lowering the heat of the heart, enhancing the sound, and strengthening the lungs, refreshing, improving winter stamina, and preventing coughs and asthma. Older people with seawater asthma or those who have had lung surgery have a prescription to win the winter, and also have a fever-lowering effect, which is effective for neuralgia and rheumatism. Excellent effect can be seen. It has been reported to quench thirst, dry skin, winter cold, and fatigue. Steroid-based saponins and opiopogonin are known as the main ingredients. The leaflet vegetation used in the present invention can be used for all parts, such as petals, leaves, roots, fruit, etc., preferably tubers (傀 莖) of the leaflet vegetation (called 'tuber stem') is suitable. On the other hand, the leaflet pulsatile sinus of the present invention may include a variety of pulmonary sinus that may exhibit the effect of the present invention.

The cosmetic composition provided by the present invention is characterized in that it contains the lobular vegetation extract. The leaflet vegetation extract according to the present invention can be prepared as follows.

The leaflet vegetation extract of the present invention can be extracted by a variety of known methods, preferably can be obtained by the following method. First, after adding a certain amount of water to the tuber of leaflet vegetation and extracting while boiling under reflux apparatus for about 30 minutes to 12 hours, filtered and the filtrate is taken and the total amount is adjusted by adding water, then 1 to 12 days at low temperature The precipitate can be obtained by performing membrane filtration of the precipitates produced by standing for one day.

In addition, the extract of the present invention includes not only an extract by an extraction solvent, but also an extract that has undergone a conventional purification process. Obtained by various additional purification methods, such as, for example, separation using ultrafiltration membranes having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity). The fraction is also included in the extract of the present invention, furthermore, the extract of the present invention may be prepared in powder form by additional processes such as distillation under reduced pressure and freeze drying or spray drying.

The cosmetic composition of the present invention preferably comprises 0.001 to 20.0% by weight of the leaflet vegetation extract relative to the total cosmetic composition. When the cosmetic composition of the present invention contains the extract at less than 0.001 weight, the effect of the cosmetic composition is insignificant, and when added in excess of 20.0% by weight, the synergistic effect due to the excess input is not economical. More preferably, the cosmetic composition of the present invention comprises 0.01 to 10.0% by weight of the extract, even more preferably 0.1 to 5.0% by weight.

The components included in the cosmetic composition of the present invention include components conventionally used in cosmetic compositions in addition to the leaf leaf vegetal extract as an active ingredient, and include, for example, conventional auxiliaries such as antioxidants, stabilizers, solubilizers, pigments and flavors, and carriers. It may include.

The cosmetic composition for skin moisturizing of the present invention, in addition to the leaflet vegetative extract, also contains other moisturizing ingredients and the like within the range of not impairing the moisturizing effect of the present invention. It's okay. In addition, it may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powders It may be formulated as a foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, the carrier components include animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silica, talc or zinc oxide. Can be used.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminium hydroxide, calcium silicate or polyamide powder may be used, especially in the case of spray, additionally chlorofluorohydrocarbon, Propellant such as propane / butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, for example water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol , Aliphatic esters of 1,3-butylglycol oil, glycerol aliphatic esters, polyethylene glycols or sorbitan.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethiotate, imidazolinium derivatives, methyltaurate, sarcosinate, fatty acid amide. Ethersulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanol amides, vegetable oil lanolin derivatives, ethoxylated glycerol or fatty acid esters and the like can be used.

Hereinafter, the present invention will be described in more detail with reference to Examples and Experimental Examples. The following Examples and Experimental Examples are only for more specifically describing the present invention, and the scope of the present invention is not limited by them according to the gist of the present invention. It will be apparent to the child. The blending amount is expressed in weight%.

Preparation Example 1 Preparation of Leaflet Vein Extract

Take 10 g of the tuber stem of the leaflet vein and add 100 ml of water each time, extract it by boiling under reflux for 3 hours, filter it with filter paper, filter the filtrate, adjust the water to 100 ml by adding water, and then adjust the adjusting solution to 4 ℃. Precipitates produced by standing for 6 days at 0.45 um membrane filtration to obtain the lobular vegetation extract.

Experimental Example 1: Cytotoxicity Test of Macmundong Extract

In order to verify the primary safety as a raw material used in cosmetics, the MTT test (Ref .: Mossman T. C.) was cultured by culturing V79-4 cells (Chinese hamster, continuous cell line of lung tissue fibroblasts) with the leaflet vegetation extract of the present invention. (1983) Rapid colorimetric assay for cellular growth & survival: application to proliferation & cytotoxicity assays.Journal of Immunological Methods, 65, 55-63) was performed to test the cytotoxicity, the results are shown in Table 1.

sample ^a IC ₅₀ (%, W / V) Sodium Lauryl Sulfate (SLS) 0.005 Bovine leaf vegetation extract 2.5

^a IC ₅₀ : Inhibitory Concentration 50, 50% cell killing concentration

As shown in Table 1, the IC ₅₀ value of the extract of McMoon Dong according to the present invention is 2.5, which is low in cytotoxicity compared to sodium lauryl sulfate, which is excellent in safety.

Experimental Example 2 Investigation of the Expression of Cladin-1 and ZO-1 Proteins in the Extracts of Lobules and Cauliflowers

About the lobular vegetation extract, Claudins-1 (Claudins-1) and ZO-1 protein expression levels were measured by Western blot. Human keratinocytes were cultured in DMEM medium (Gibco / BRL) containing 10% bovine serum (Gibco / BRL) at a density of 1 × 10 ⁶ in a 60 mm culture dish in a 37 ° C., 5% CO 2 incubator for one day. Raised Thereafter, the cells were exchanged with a serum-free medium, and the samples were added at a concentration of 0.5 and 1.0% and incubated at 37 ° C. for 24 hours. Thereafter, the cell cultures were concentrated by using a concentrated filter Millipore (Millipore), and the protein was quantified according to the BCA method (Sigma) and used for western blotting. The same amount of protein was electrophoresed on a SDS-PAGE gel consisting of a 7% separating gel and a 5% staking gel and a semi-dry transfer device (Biorad). ) To transfer the electrophoretic protein to PVDF membrane, and then treated with the primary antibody Anti-Claudins-1 and anti-ZO-1 antibodies. After completion, the HRP conjugated secondary antibody was treated and confirmed by photosensitive X-ray (X-ray) film after an ECL (enhanced chemiluminescence, Intron) reaction. Claudins-1 and ZO-1 protein expression levels were determined by using an image analyzer (Biorad) on the bands exposed to the film, and the experimental results are shown in Table 2, and 1.2mM CaCl ₂ was used as a control. Was used.

sample Synthesis amount (%) Claudins-1 ZO-1 No treatment group 100 100 1.2 mM CaCl ₂ 145 126 0.5% leaflet vegetation extract 120 119 1.0% leaflet vegetation extract 125 124

As shown in the results of Experimental Example 2, cladins-1 (Claudins-1) was increased 25%, ZO-1 was increased by 24% in 1.0% of the extract.

Experimental Example 3. Filagrin (Flaggrin) Formation Promoting Effect

To investigate the production of natural moisturizing factors that have a significant effect on moisturization in skin, the synthesis of filaggrin, a precursor of natural moisturizing factors, was tested in human keratinocytes. After culturing human keratinocytes (Keratinocyte) in the same manner as in Experimental Example 2, lobular vegetation extract was treated for 2 days. After the treatment was completed, the medium was removed and only the cells were taken. After crushing the cells by using a sonicator, only proteins were obtained. Using this protein, the amount of filaggrin synthesized by western blotting was examined. Table 3 shows the results of quantifying the amount of filaggrin expressed by the antibody of filaggrin by using an image analyzer (Image analyzer, Biorad).

sample Pillar Green Growth (%) 0.03 mM CaCl ₂ 100 1.2 mM CaCl ₂ 265 1.0% leaflet vegetation extract 216

 It was found that the increase. Therefore, the increase in the synthesis of the natural moisturizing factor pilagrin precursor was able to confirm the increase of the natural moisturizing factor indirectly.

ingredient
Content (% by weight) Example Comparative Example 1 Comparative Example 2 1.Vaseline 7.0 7.0 7.0 2.fluid paraffin 10.0 10.0 10.0 3. wax 2.0 2.0 2.0 4.Polysorbate-60 2.0 2.0 2.0 5.Solbitan sesquioleate 2.5 2.5 2.5 6.Squalane 3.0 3.0 3.0 7.propylene glycol 6.0 6.0 6.0 8.Glycerin 4.0 4.0 4.0 9.triethanolamine 0.5 0.5 0.5 10. Carboxyvinyl Polymer 0.5 0.5 0.5 11.Tocopherol Acetate 0.1 0.1 0.1 12.Purified water To 100 To 100 To 100 13.Leave leaf vein sinus extract 4.0 - - 14.Sodium Hyaluronate - 0.1 - 15.Fragrance, Preservative a very small amount a very small amount a very small amount

Preparation Example 2 Examples and Comparative Examples 1 and 2

The manufacturing methods of Examples and Comparative Examples 1 and 2 are as follows. 1) Warm 1-6 to 70 ° C while stirring to form an oily solution. 2) Add 7-8 and 10-11 to purified water and warm to 70 ℃ while stirring to make aqueous phase solution. 3) The oily solution 1) and the raw material 9) are mixed with 2), and then emulsified and cooled. 4) The raw materials 13-15 are added to 3), mixed and cooled to 30 ° C. to obtain Examples and Comparative Examples 1,2.

Experimental Example 4: Moisturizing Effect

In order to evaluate the moisturizing power of each of the cosmetic preparations prepared in Examples and Comparative Examples 1 and 2, the moisture retention capacity and the water evaporation amount were measured as follows on the skin to which each cosmetic was applied.

Experimental Example 4-1: Measurement of Moisture Retention Capacity

Experimental effect of improving the skin moisturizing power for the cosmetic prepared in the composition of Table 4. 60 people in their 20s to 30s without skin diseases were divided into three groups of 20 people per group, and each group was given an Example, Comparative Examples 1 and 2, and applied to the face and forearm twice a day for 1 month. . Before starting the application, measure skin electrical conductivity using corneometer (CM820 courage Khazaka electronic GmbH, Germany) at temperature and humidity conditions (24 ℃, 40% humidity). Skin electrical conductivity was measured after 4 weeks and after 2 weeks (6 weeks). The results are shown in Table 5 below.

division 0 weeks later 1 week later after 2 weeks 4 weeks later 6 weeks later Example 30 55 58 64 52 Comparative Example 1 28 41 45 50 38 Comparative Example 2 30 30 32 35 25

Experimental Example 4-2: Measurement of Water Evaporation Amount

After tape stripping on the upper arm of the arm to weaken the skin's protective film, 30 cosmetics prepared in Examples and Comparative Examples 1 and 2 were prepared in a constant temperature and humidity chamber of 22 ° C. and 45% relative humidity. After applying a certain amount (0.03 g / 16 ㎠) to the inside of the Habakkuk test subject, using a water evaporator (Tewameter TM300, Courage + Khazaka Co., Germany), measure the amount of water evaporation 5 times at 1 minute intervals every 12 hours The mean value was obtained and normal skin without any treatment was used as a control. The results are shown in Table 6 below.

division Example (%) Comparative Example 1 (%) Comparative Example 2 (%) Control group (%) Moisture evaporation after 0 hours 100.0 100.0 100.0 100.0 Moisture evaporation after 12 hours 76.8 82.5 87.3 92.0 Moisture evaporation after 24 hours 58.1 69.1 74.1 84.0 Moisture evaporation after 36 hours 41.5 54.3 62.8 77.6 Moisture evaporation after 48 hours 28.2 44.2 52.4 70.2

As shown in the results of Experimental Examples 4-1 and 4-2, the cosmetic agent of the present invention exhibited higher electrical conductivity of the skin and less water loss than the cosmetic agents of Comparative Examples 1 and 2. Since the skin electrical conductivity is proportional to the skin moisture content, it can be seen that the skin moisture content increase effect of the embodiment is very excellent. In addition, in the case of the Example 2 weeks after the suspension of use (after 6 weeks in total) it can be seen that the moisture content is maintained as compared to Comparative Examples 1 and 2 have a long-term moisturizing effect. Therefore, it can be seen that the cosmetic containing the leaflet vegetation extract shows a very excellent moisturizing effect.

Experimental Example 5: Stability Test of the Formulation

The stability test for the cosmetic containing the extract of the present invention was carried out by the following method.

In order to test the stability of the cosmetics, Examples and Comparative Examples 1 and 2 were kept in an opaque glass container in a constant temperature bath at a constant temperature of 45 ° C. and stored for 12 weeks in a completely shaded refrigerator kept at a constant temperature of 4 ° C. After storing in an opaque glass container for 12 weeks, the discoloration, odor, and degree of separation were measured. The results are summarized in Table 7 below. At this time, the degree of product discoloration, odor and separation were evaluated by classifying into the following six grades: 0: no change; 1: very little separation (discoloration); 2: a little separation (discoloration); 3: slightly severe separation (discoloration); 4: severe separation (discoloration); And 5: extremely severe separation (discoloration).

division Formulation Stability Example Comparative Example 1 Comparative Example 2 45 ℃ 4 ℃ 45 ℃ 4 ℃ 45 ℃ 4 ℃ discoloration 0 0 0 0 0 0 Deodorant 0 0 0 0 0 0 detach 0 0 0 0 0 0

As can be seen in Table 7, Examples and Comparative Examples 1 and 2 were stable at 45 ° C. with little discoloration, discoloration, or separation, indicating that the Macmundong extract was present in a stable state in the formulation.

Hereinafter, based on the results of the above experimental example, to present a cosmetic composition containing the leaflet vegetation extract of the present invention. However, the composition of the present invention is not intended to be limited to the following formulation examples.

Formulation Example 1: Softener (Skin Lotion)

As shown in the following table, the softening lotion was prepared according to a conventional method.

Compounding ingredient Content (% by weight) Bovine leaf vegetation extract 1.0 1.3-butylene glycol 6.0 glycerin 4.0 Oleyl alcohol 0.1 Polysorbate 20 0.5 ethanol 15.0 Benzophenone-9 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 2. Nutrients (Milk Lotion)

Nutrients were prepared according to a conventional method as shown in the table below.

Compounding ingredient Content (% by weight) Bovine leaf vegetation extract 2.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 1.2 Tocophenyl Acetate 3.0 Liquid paraffin 5.0 Squalane 3.0 Macadamia Nut Oil 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.0 Carboxyvinyl Polymer 1.0 Bietchiti 0.01 EDTA-2Na 0.01 Incense, preservative a very small amount Purified water to 100

Formulation Example 3. Nutrition Cream

Nutritious cream was prepared according to a conventional method as shown in the following table.

Compounding ingredient Content (% by weight) Bovine leaf vegetation extract 4.0 Cetostearyl alcohol 2.0 Glyceryl Stearate 1.5 Trioctanoine 5.0 Polysorbate 60 1.2 Sorbitan stearate 0.5 Squalane 5.0 Floating paraffin 3.0 Cyclomethicone 3.0 BH 0.05 Delta-tocopherol 0.2 Concentrated glycerin 4.0 1,3-butylene glycol 2.0 Santa sword 0.1 EDTA-2Na 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 4 Massage Cream

Massage cream was prepared according to a conventional method as shown in the table below.

Compounding ingredient Content (% by weight) Bovine leaf vegetation extract 1.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Beeswax 2.0 Tocopheryl acetate 0.1 Polysorbate 60 3.0 Sorbitan sesquioleate 2.5 Cetearyl Alcohol 2.0 Liquid paraffin 30.0 Carboxy Vinyl Polymer 0.5 Incense, preservative a very small amount Purified water to 100

Formulation Example 5 Pack

Packs were prepared according to conventional methods as shown in the table below.

Compounding ingredient Content (% by weight) Bovine leaf vegetation extract 1.0 Propylene glycol 2.0 glycerin 4.0 Carboxyvinyl Polymer 0.3 ethanol 7.0 Fiji-40 Hydrogenated Castor Oil 0.8 Triethanolamine 0.3 Bietchiti 0.01 EDTA-2Na 0.01 Incense, preservative a very small amount Purified water to 100

Claims (5)

Cosmetic composition for skin moisturizing containing leaflet vegetation extract as an active ingredient. The cosmetic composition for moisturizing skin according to claim 1, wherein the leaflet vegetation extract is contained in an amount of 0.001 to 20.0% by weight based on the total weight of the cosmetic composition. According to claim 1, wherein the leaflet vegetation extract, A cosmetic composition for moisturizing skin, characterized by promoting the synthesis of claudein-1 and zonula oculudin-1. According to claim 1, wherein the leaflet vegetation extract, A cosmetic composition for moisturizing skin, characterized by promoting filaggrin synthesis and / or increasing NMF. According to claim 1, wherein the cosmetic composition is a skin moisturizing cosmetic composition, characterized in that formed in one formulation selected from lotion, essence, lotion, cream, pack, gel, ointment, patch, or spray.