CN111228166A - Soothing skin cream for infants and preparation method thereof - Google Patents
Soothing skin cream for infants and preparation method thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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Abstract
The invention relates to a soothing skin cream for infants, which is prepared from the following raw materials in parts by weight: 13.2-33 parts of phase A component; 2.1-5 parts of a B1 phase component; 37-81.7 parts of a B2 phase component; 0.2-4 parts of a phase C component; 0.5-10 parts of phase D component; 0.2-4 parts of an E phase component; 2.1-7 parts of a phase F component; wherein: the phase A component consists of BIO-BASES, alcohol A165 and 1618, DS-166, 2EHP and DC200\ 350; the phase B1 consists of 1, 3-butanediol and xanthan gum; phase B2 comprises water, glycerol, carbopol 940 and allantoin; the phase C component consists of EG and phenytoin; the phase D component consists of portulaca, maltotetraose, liquorice extract and K350; the phase E component consists of D.A and propylene glycol; the F phase component consists of arginine and water; its preparing process is also disclosed. The invention achieves the effect of relieving the skin of the infant after miliaria and eczema of the infant is generated by safe anti-inflammatory and antibacterial components, and achieves the effect of relieving the skin after the skin is stimulated by the pharmacological action of extracts such as bisabolol, purslane extract and the like.
Description
Technical Field
The invention relates to the technical field of infant skin care products, in particular to infant soothing skin cream and a preparation method thereof.
Background
The skin of a baby is very sensitive and fragile, the skin area is relatively large, and sweat evaporated from skin pores is 2 times that of an adult; the skin angle layer is thinner than the larger person, and the capability of preventing harmful substances from invading is weak; the skin contains much water, which accounts for about 13% of the water in the body, while the skin accounts for only 7% of the water in the body; the skin is alkaline and acidic in adults. The bacteria are just acidic, so the skin of the infant is susceptible to bacterial infection. The skin of children is about 20-30% thinner than that of adults, the epidermal cells are only 3-4 layers, the skin is smooth and tender in appearance, unclear in texture and easy to damage, and miliaria, eczema and other erythra diseases can easily occur once the skin is induced by external stimulation such as various animal skins, plants, artificial fibers and the like. The red swelling and pruritus caused by the skin diseases are intolerable to babies, but the influence caused by external factors can be prevented through prevention. On the market, various products are used for treating miliaria and eczema, and most products with good effects are word elimination products, or medicines added with glucocorticoid and the like, such as triamcinolone acetonide cream, mometasone furoate cream and the like, belong to hormone medicines. Therefore, it is necessary to prepare a safe and effective targeted cream which can relieve and relieve symptoms after miliaria and eczema of infants.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a soothing and soothing skin cream for infants and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
a soothing skin cream for infants is prepared from the following raw materials in parts by weight:
wherein:
the phase A component consists of BIO-BASES, alcohol A165 and 1618, DS-166, 2EHP and DC200\ 350;
the phase B1 consists of 1, 3-butanediol and xanthan gum;
phase B2 comprises water, glycerol, carbopol 940 and allantoin;
the phase C component consists of EG and phenytoin;
the phase D component consists of portulaca, maltotetraose, liquorice extract and K350;
the phase E component consists of D.A and propylene glycol;
the F phase component consists of arginine and water.
Further, the phase A component comprises the following raw materials in parts by weight:
further, the B1 phase component comprises the following raw materials in parts by weight:
2-4 parts of 1, 3-butanediol;
0.1-1 part of xanthan gum.
Further, the B2 phase component comprises the following raw materials in parts by weight:
further, the phase C component comprises the following raw materials in parts by weight:
0.1-2 parts of EG;
0.1-2 parts of euphorbia tirucalli.
Further, the phase D component comprises the following raw materials in parts by weight:
further, the phase E component comprises the following raw materials in parts by weight:
D.A 0.1.1-2 parts;
0.1-2 parts of propylene glycol.
Further, the phase F component comprises the following raw materials in parts by weight:
0.1-2 parts of propylene glycol;
2-5 parts of water.
The preparation method of the infant soothing skin cream comprises the following steps:
s1, cleaning and disinfecting production equipment, accurately weighing various materials in the A-phase component, the B1-phase component, the B2-phase component, the C-phase component, the D-phase component, the E-phase component and the F-phase component, and placing the materials in a clean and disinfected container;
s2, sequentially putting the weighed materials of the phase A component into an oil phase pot, stirring and heating to 75-80 ℃, and uniformly stirring for later use;
s3, sequentially putting the dispersed B1 phase component and B2 phase component into a water phase pot, homogenizing until the colloid is dissolved, stirring and heating to 80-90 ℃, and sterilizing at constant temperature for 20-40 min for later use;
s4, pumping the B1 phase component and the B2 phase component into an emulsifying pot heated by a jacket, putting the A phase component into the emulsifying pot, stirring and pre-emulsifying for 3-5 min, putting the C phase component, starting high-speed homogenization, homogenizing for 5-10 min, taking out the small materials, cooling, observing, and vacuumizing the pot.
And S5, starting cooling water for cooling circularly, cooling to 45 ℃, sequentially adding the phase D component and the phase E component dissolved by micro heat, stirring uniformly, and adjusting the pH to 6.5-7.0 by using the phase F component.
And S6, after the small sample is inspected to be qualified, filtering the small sample by using filter cloth of 200-300 meshes and discharging.
Further, in step S4, the stirring speed of the high-speed homogenization is 1000-1200 rpm; in step S5, the cooling rate is 0.6-0.8 ℃/min.
The invention has the following advantages:
1. the invention provides a safe and effective soothing cream for solving the problems of miliaria and eczema without adding hormone, which achieves the effect of soothing the skin of a baby after the baby has miliaria and eczema through safe anti-inflammatory and antibacterial components, and achieves the effect of soothing the skin after the skin is stimulated through the pharmacological action of extracts such as bisabolol and purslane extracts.
2. The invention is developed according to the characteristics of the skin of the baby, and can relieve various discomfort phenomena of the skin.
3. The invention selects natural multifunctional plant raw materials, is mild and has no irritation.
4. The bisabolol extract of the present invention has been proved to have bacteriostatic activity in addition to anti-inflammatory properties.
5. The invention does not add substances such as essence, alcohol, pigment and the like which are often added in cosmetics and easily cause skin irritation safety problems.
6. The allantoin can directly act on keratin, increase and promote the hydration ability of the horny layer, increase the water binding ability of the horny layer, reduce the water loss, make the skin smooth, moist and flexible, and can relieve and treat xerosis cutis and moisten the skin. In addition, allantoin also has anti-inflammatory and anti-irritant effects. In the invention, besides having a good repairing function, allantoin is also a good humectant and anti-allergy agent, which can keep skin moisture, maintain the physiological balance of skin moisture, and relieve the stimulation of active substances to the skin.
7. The purslane contains a large amount of flavonoids, adrenalines, polysaccharides, various vitamins, amino acids and other compounds. The purslane extract can reduce the secretion of inflammatory factor interleukin and has certain anti-inflammatory effect, thereby relieving skin inflammation and inhibiting skin itch caused by dryness, and is mainly used for resisting allergy, inflammation and resisting various stimulation effects of the external world on skin in cosmetics, and particularly has obvious anti-allergic effect on skin allergy generated by long-term use of hormone cosmetics. Has good curative effect on eczema, dermatitis, skin pruritus and pain.
Detailed Description
The invention is further described below with reference to examples, but the scope of the invention is not limited to the following.
[ example 1 ]
A soothing skin cream for infants is prepared from the following raw materials in parts by weight:
wherein:
the phase A component consists of BIO-BASES, alcohol A165 and 1618, DS-166, 2EHP and DC200\ 350;
the phase B1 consists of 1, 3-butanediol and xanthan gum;
phase B2 comprises water, glycerol, carbopol 940 and allantoin;
the phase C component consists of EG and phenytoin;
the phase D component consists of portulaca, maltotetraose, liquorice extract and K350;
the phase E component consists of D.A and propylene glycol;
the F phase component consists of arginine and water.
In this embodiment, the phase a component comprises the following raw materials in parts by weight:
in this embodiment, the B1 phase component comprises the following raw materials in parts by weight:
2 parts of 1, 3 butanediol;
0.1 part of xanthan gum.
In this embodiment, the B2 phase component comprises the following raw materials in parts by weight:
in this embodiment, the phase C component comprises the following raw materials in parts by weight:
0.1 part of EG;
0.1 part of Anmin Shu.
In this embodiment, the phase D component comprises the following raw materials in parts by weight:
in this embodiment, the phase E component comprises the following raw materials in parts by weight:
D.A 2 parts of a binder;
and 2 parts of propylene glycol.
In this embodiment, the phase F component comprises the following raw materials in parts by weight:
0.1 part of propylene glycol;
and 2 parts of water.
The preparation method of the infant soothing skin cream comprises the following steps:
s1, cleaning and disinfecting production equipment, accurately weighing various materials in the A-phase component, the B1-phase component, the B2-phase component, the C-phase component, the D-phase component, the E-phase component and the F-phase component, and placing the materials in a clean and disinfected container;
s2, sequentially putting the weighed materials of the phase A component into an oil phase pot, stirring and heating to 80 ℃, and uniformly stirring for later use;
s3, sequentially putting the dispersed B1 phase component and B2 phase component into a water phase pot, homogenizing until the colloid is dissolved, stirring and heating to 80 ℃, and sterilizing at constant temperature for 40min for later use;
s4, pumping the phase B1 and the phase B2 into an emulsifying pot heated by a jacket, putting the phase A into the emulsifying pot, stirring and pre-emulsifying for 3min, putting the phase C, starting high-speed homogenizing, homogenizing for 10min, cooling the small materials, observing, and vacuumizing the pot.
And S5, starting cooling water to circularly cool to 45 ℃, sequentially adding the phase D component and the phase E component dissolved by micro heat, uniformly stirring, and adjusting the pH to 6.5 by using the phase F component.
And S6, after the small sample is inspected to be qualified, filtering the small sample by using 300-mesh filter cloth and discharging the filtered small sample.
In this embodiment, in step S4, the stirring speed for high-speed homogenization is 1000 rpm; in step S5, the cooling rate is 0.8 ℃/min.
[ example 2 ]
A soothing skin cream for infants is prepared from the following raw materials in parts by weight:
wherein:
the phase A component consists of BIO-BASES, alcohol A165 and 1618, DS-166, 2EHP and DC200\ 350;
the phase B1 consists of 1, 3-butanediol and xanthan gum;
phase B2 comprises water, glycerol, carbopol 940 and allantoin;
the phase C component consists of EG and phenytoin;
the phase D component consists of portulaca, maltotetraose, liquorice extract and K350;
the phase E component consists of D.A and propylene glycol;
the F phase component consists of arginine and water.
In this embodiment, the phase a component comprises the following raw materials in parts by weight:
in this embodiment, the B1 phase component comprises the following raw materials in parts by weight:
3 parts of 1, 3 butanediol;
0.5 part of xanthan gum.
In this embodiment, the B2 phase component comprises the following raw materials in parts by weight:
in this embodiment, the phase C component comprises the following raw materials in parts by weight:
1 part of EG;
and 1 part of Xin Min Shu.
In this embodiment, the phase D component comprises the following raw materials in parts by weight:
in this embodiment, the phase E component comprises the following raw materials in parts by weight:
D.A 1 parts of a binder;
1 part of propylene glycol.
In this embodiment, the phase F component comprises the following raw materials in parts by weight:
1 part of propylene glycol;
and 3.5 parts of water.
The preparation method of the infant soothing skin cream comprises the following steps:
s1, cleaning and disinfecting production equipment, accurately weighing various materials in the A-phase component, the B1-phase component, the B2-phase component, the C-phase component, the D-phase component, the E-phase component and the F-phase component, and placing the materials in a clean and disinfected container;
s2, putting the weighed materials of the phase A component into an oil phase pot in sequence, stirring and heating to 78 ℃, and stirring uniformly for later use;
s3, sequentially putting the dispersed B1 phase component and B2 phase component into a water phase pot, homogenizing until the colloid is dissolved, stirring and heating to 85 ℃, and sterilizing at constant temperature for 30min for later use;
s4, pumping the phase B1 and the phase B2 into an emulsifying pot heated by a jacket, putting the phase A into the emulsifying pot, stirring and pre-emulsifying for 4min, putting the phase C, starting high-speed homogenizing, homogenizing for 7min, taking out the small materials, cooling, observing, and vacuumizing the pot.
And S5, starting cooling water to circularly cool to 45 ℃, sequentially adding the phase D component and the phase E component dissolved by micro heat, uniformly stirring, and adjusting the pH to 6.8 by using the phase F component.
And S6, filtering and discharging the sample by using a filter cloth of 250 meshes after the sample is qualified through inspection.
In the present embodiment, in step S4, the stirring speed for high-speed homogenization is 1100 rpm; in step S5, the cooling rate is 0.7 ℃/min.
[ example 3 ]
A soothing skin cream for infants is prepared from the following raw materials in parts by weight:
wherein:
the phase A component consists of BIO-BASES, alcohol A165 and 1618, DS-166, 2EHP and DC200\ 350;
the phase B1 consists of 1, 3-butanediol and xanthan gum;
phase B2 comprises water, glycerol, carbopol 940 and allantoin;
the phase C component consists of EG and phenytoin;
the phase D component consists of portulaca, maltotetraose, liquorice extract and K350;
the phase E component consists of D.A and propylene glycol;
the F phase component consists of arginine and water.
In this embodiment, the phase a component comprises the following raw materials in parts by weight:
in this embodiment, the B1 phase component comprises the following raw materials in parts by weight:
2.5 parts of 1, 3-butanediol;
0.5 part of xanthan gum.
In this embodiment, the B2 phase component comprises the following raw materials in parts by weight:
in this embodiment, the phase C component comprises the following raw materials in parts by weight:
1.5 parts of EG;
1.5 portions of Xin Min Shu.
In this embodiment, the phase D component comprises the following raw materials in parts by weight:
in this embodiment, the phase E component comprises the following raw materials in parts by weight:
D.A 1.5.5 parts;
1.5 parts of propylene glycol.
In this embodiment, the phase F component comprises the following raw materials in parts by weight:
1 part of propylene glycol;
and 4 parts of water.
The preparation method of the infant soothing skin cream comprises the following steps:
s1, cleaning and disinfecting production equipment, accurately weighing various materials in the A-phase component, the B1-phase component, the B2-phase component, the C-phase component, the D-phase component, the E-phase component and the F-phase component, and placing the materials in a clean and disinfected container;
s2, putting the weighed A-phase components into an oil phase pot in sequence, stirring and heating to 77 ℃, and stirring uniformly for later use;
s3, sequentially putting the dispersed B1 phase component and B2 phase component into a water phase pot, homogenizing until the colloid is dissolved, stirring and heating to 82 ℃, and sterilizing at constant temperature for 35min for later use;
s4, pumping the phase B1 and the phase B2 into an emulsifying pot heated by a jacket, putting the phase A into the emulsifying pot, stirring and pre-emulsifying for 4min, putting the phase C, starting high-speed homogenizing, homogenizing for 8min, taking out the small materials, cooling, observing, and vacuumizing the pot.
And S5, starting cooling water to circularly cool to 45 ℃, sequentially adding the phase D component and the phase E component dissolved by micro heat, uniformly stirring, and adjusting the pH to 6.6 by using the phase F component.
And S6, after the small sample is inspected to be qualified, filtering the small sample by using filter cloth of 200-300 meshes and discharging.
In this embodiment, in step S4, the stirring speed for high-speed homogenization is 1250 rpm; in step S5, the cooling rate is 0.7 ℃/min.
[ example 4 ]
A soothing skin cream for infants is prepared from the following raw materials in parts by weight:
wherein:
the phase A component consists of BIO-BASES, alcohol A165 and 1618, DS-166, 2EHP and DC200\ 350;
the phase B1 consists of 1, 3-butanediol and xanthan gum;
phase B2 comprises water, glycerol, carbopol 940 and allantoin;
the phase C component consists of EG and phenytoin;
the phase D component consists of portulaca, maltotetraose, liquorice extract and K350;
the phase E component consists of D.A and propylene glycol;
the F phase component consists of arginine and water.
In this embodiment, the phase a component comprises the following raw materials in parts by weight:
in this embodiment, the B1 phase component comprises the following raw materials in parts by weight:
4 parts of 1, 3-butanediol;
1 part of xanthan gum.
In this embodiment, the B2 phase component comprises the following raw materials in parts by weight:
in this embodiment, the phase C component comprises the following raw materials in parts by weight:
EG 2 parts;
2 portions of Xin Min Shu.
In this embodiment, the phase D component comprises the following raw materials in parts by weight:
in this embodiment, the phase E component comprises the following raw materials in parts by weight:
D.A 0.1.1 parts;
0.1 part of propylene glycol.
In this embodiment, the phase F component comprises the following raw materials in parts by weight:
2 parts of propylene glycol;
and 2 parts of water.
The preparation method of the infant soothing skin cream comprises the following steps:
s1, cleaning and disinfecting production equipment, accurately weighing various materials in the A-phase component, the B1-phase component, the B2-phase component, the C-phase component, the D-phase component, the E-phase component and the F-phase component, and placing the materials in a clean and disinfected container;
s2, sequentially putting the weighed materials of the phase A component into an oil phase pot, stirring and heating to 75 ℃, and uniformly stirring for later use;
s3, sequentially putting the dispersed B1 phase component and B2 phase component into a water phase pot, homogenizing until the colloid is dissolved, stirring and heating to 90 ℃, and sterilizing at constant temperature for 20min for later use;
s4, pumping the phase B1 and the phase B2 into an emulsifying pot heated by a jacket, putting the phase A into the emulsifying pot, stirring and pre-emulsifying for 5min, putting the phase C, starting high-speed homogenizing, homogenizing for 5min, taking out the small materials, cooling, observing, and vacuumizing the pot.
And S5, starting cooling water to circularly cool to 45 ℃, sequentially adding the phase D component and the phase E component dissolved by micro heat, uniformly stirring, and adjusting the pH to 7.0 by using the phase F component.
And S6, filtering and discharging the sample by using 200-mesh filter cloth after the sample is qualified through inspection.
In this embodiment, in step S4, the stirring speed for high-speed homogenization is 1200 rpm; in step S5, the cooling rate is 0.6 ℃/min.
The sources and types of some raw materials in the above examples are shown in table 1:
verification of effects
30 infant patients with sensitive skin were selected and divided into 3 groups of 10 persons, each group of testers used the infant soothing cream of example 1 and examples 2 and 3, respectively, and the infant soothing cream was applied to the sensitive skin uniformly once in the morning and at night, the control group was the same infant sensitive skin patient, but a part of the infant soothing cream was not applied to the control group, and the skin condition of the user was observed on the 3 rd day, the 5 th day and the 7 th day of use, respectively. If the skin is tested to have no redness and swelling, blood streak, it is considered to have the function of relieving inflammation. When the skin barrier function is recovered and no discomfort is caused in the test, the skin is considered to have the skin repairing effect. The action effect is divided into 1-10 points, and the 10 points have the most obvious action effect. The test results are shown in Table 2.
Table 2 shows the results of using the soothing cream for infants of examples 1, 2, 3 and the blank group
As can be seen from table 2, the skin of the test subjects using the baby soothing skin cream in the examples was effectively soothed, and example 2 exhibited an obvious soothing effect; through tests, the longer the usage time is, the more obvious the effect is. The control group starts to show the self-relieving effect only at the 5 th day and starts to show the repairing effect at the 7 th day depending on the self-regulation and repairing capability of the human body; it can also be seen that the baby soothing skin cream has significant effects in diminishing inflammation, soothing and repairing skin.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. A soothing and soothing skin cream for infants is characterized in that: the feed is prepared from the following raw materials in parts by weight:
wherein:
the phase A component consists of BIO-BASES, alcohol A165 and 1618, DS-166, 2EHP and DC200\ 350;
the phase B1 consists of 1, 3-butanediol and xanthan gum;
phase B2 comprises water, glycerol, carbopol 940 and allantoin;
the phase C component consists of EG and phenytoin;
the phase D component consists of portulaca, maltotetraose, liquorice extract and K350;
the phase E component consists of D.A and propylene glycol;
the F phase component consists of arginine and water.
2. The infant soothing skin cream according to claim 1, wherein: the phase A component comprises the following raw materials in parts by weight:
3. an infant soothing skin cream as claimed in claim 2, wherein: the B1 phase component comprises the following raw materials in parts by weight:
2-4 parts of 1, 3-butanediol;
0.1-1 part of xanthan gum.
4. The infant soothing skin cream according to claim 3, wherein: the B2 phase component comprises the following raw materials in parts by weight:
5. the infant soothing skin cream according to claim 4, wherein: the phase C component comprises the following raw materials in parts by weight:
0.1-2 parts of EG;
0.1-2 parts of euphorbia tirucalli.
6. An infant soothing skin cream as claimed in claim 5, wherein: the phase D component comprises the following raw materials in parts by weight:
7. the infant soothing skin cream of claim 6, wherein: the phase E component comprises the following raw materials in parts by weight:
D.A 0.1.1-2 parts;
0.1-2 parts of propylene glycol.
8. The infant soothing skin cream of claim 7, wherein: the F phase component comprises the following raw materials in parts by weight:
0.1-2 parts of propylene glycol;
2-5 parts of water.
9. A method of preparing an infant soothing cream as claimed in any one of claims 1 to 8, wherein: the method comprises the following steps:
s1, cleaning and disinfecting production equipment, accurately weighing various materials in the A-phase component, the B1-phase component, the B2-phase component, the C-phase component, the D-phase component, the E-phase component and the F-phase component, and placing the materials in a clean and disinfected container;
s2, sequentially putting the weighed materials of the phase A component into an oil phase pot, stirring and heating to 75-80 ℃, and uniformly stirring for later use;
s3, sequentially putting the dispersed B1 phase component and B2 phase component into a water phase pot, homogenizing until the colloid is dissolved, stirring and heating to 80-90 ℃, and sterilizing at constant temperature for 20-40 min for later use;
s4, pumping the B1 phase component and the B2 phase component into an emulsifying pot heated by a jacket, putting the A phase component into the emulsifying pot, stirring and pre-emulsifying for 3-5 min, putting the C phase component, starting high-speed homogenization, homogenizing for 5-10 min, taking out the small materials, cooling, observing, and vacuumizing the pot.
And S5, starting cooling water for cooling circularly, cooling to 45 ℃, sequentially adding the phase D component and the phase E component dissolved by micro heat, stirring uniformly, and adjusting the pH to 6.5-7.0 by using the phase F component.
And S6, after the small sample is inspected to be qualified, filtering the small sample by using filter cloth of 200-300 meshes and discharging.
10. The method for preparing an infant soothing skin cream according to claim 9, wherein the method comprises the following steps: in step S4, the stirring speed of the high-speed homogenization is 1000-1200 rpm; in step S5, the cooling rate is 0.6-0.8 ℃/min.
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