CN105769654B - A kind of Shu Min skin care compositions and its application in cosmetics - Google Patents
A kind of Shu Min skin care compositions and its application in cosmetics Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/59—Mixtures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a kind of Shu Min skin care compositions and its applications in cosmetics.The Shu Min skin care compositions contains following component: cactus extraction 1~10%, Purslane extract 0.3~10%, extract solution from aloe 0.5~10%, centella asiatica extract 0.5~5%, dried tremella extract 1~6%.Composition source of the invention is natural, it is non-stimulated, have and inhibit itch well, releive skin tender subject and moisturizing the effect of, and preparation method is easy.The present invention can be made into the dosage forms such as facial cleanser, cream, lotion, facial mask, various aqua products (toner, smoothing toner, toner, nutritive water, water of releiving).
Description
Technical field
The present invention relates to a kind of Shu Min skin care compositions and its applications, belong to daily chemical products technical field.
Background technique
Skin is the largest organ of human body, is the first line of defence of human body.When skin is stimulated by certain, can usually send out
Raw shouting pain burns, is tight, the allergic reactions such as sufferings.With the continuous development of modern society, the use of cosmetics, chemicals
It is continuously increased, the original sensitizer such as increasing environmental pollution and pollen, certain foods all makes skin allergy
Possibility is continuously increased.
It is constantly increasing the crowd of sensitive, according to incompletely statistics, the whole world is felt
The crowd for belonging to sensitive skin is more and more, and wherein male accounts for about 38%, and women accounts for about 62%.Skin allergy is one very common
Physiological reaction, most people can all have the experience of skin allergy, although what serious disease skin allergy is not, but usually
Make us being difficult to endure, suffer untold misery.Due to one of cosmetics and sensibiligen, the consumer of part sensibility skin is even selected
Stop using cosmetics.
Certainly, this is a kind of way of passiveness, properly uses cosmetics and necessary skin nursing, is that skin can be enhanced
Skin is to the resistance of sensibiligen.Therefore, consumer needs a kind of source natural, have moisturizing, Shu Min, anti-inflammatory, stimulation of releiving,
To the skin care compositions of sensitive skin safety.
Summary of the invention
The purpose of the present invention is to provide it is a kind of with moisturizing, Shu Min, anti-inflammatory, releive stimulation etc. functions Shu Min skin care group
Close object.
It is a further object of the present invention to provide excessively a kind of applications of Shu Min skin care compositions, on the basis of the composition,
By add other auxiliary materials preparations have moisturizing, Shu Min, anti-inflammatory, the functions such as stimulation of releiving cosmetics.
The present invention is that it is realized by adopting the following technical scheme.
A kind of Shu Min skin care compositions based on the weight percent in cosmetics, contains following component by addition:
Cactus extraction 1~10%, Purslane extract 0.3~10%, extract solution from aloe 0.5~10%, centella
Extracting solution 0.5~5%, dried tremella extract 1~6%.
Shu Min skin care compositions of the present invention, the cactus extraction, Purslane extract, extract solution from aloe,
Centella asiatica extract follows the example of extraction by alcohol extracting；By mentioning for dried tremella extract and above-mentioned cactus, purslane, aloe and centella
Liquid is taken to be mixed evenly to get easypro sensitive composition.
Shu Min skin care compositions of the present invention, the cactus extraction, Purslane extract, extract solution from aloe are
It is made by following processing step:
1) 75% ethanol solution of 3 times of the component is added in cactus, purslane, aloe and centella, is placed in 50kHz's
Ultrasound 3 minutes, are crushed to 100 mesh and are uniformly mixed, then be soaked in the 75% of 8~10 times of corresponding component in ultrasonic cleaning instrument
In ethanol solution, 3~4 hours are stood, and under the conditions of 80 DEG C, refluxing extraction 2 hours, stops heating, be cooled to room temperature (25
DEG C), the filtering of 200~300 mesh obtains filtrate；
2) the 1 of original amount of alcohol is added in filtrate, 3 butanediols are miscible uniformly；1.2 microns of filter plates are spread in Buchner funnel；
Above-mentioned gained filtrate is filtered by vacuum, collects filtrate to obtain the final product.
Shu Min skin care compositions of the present invention, the dried tremella extract are made of following methods:
The water of 3 times of the tremella quality is added, is placed in ultrasound 3 minutes in the ultrasonic cleaning instrument of 50kHz, adds institute
8~10 times of tremella quality of water is stated, normal heating flows back 2.5~3.5 hours, stops heating, is cooled to room temperature (25 DEG C), 200
Filtrate is concentrated in the filtering of~300 mesh, dry to get dried tremella extract.
Application of the Shu Min skin care compositions of the present invention in cosmetics, by weight percentage, the Shu Min shield
Skin composition accounts for the 3.3%~41% of cosmetic formulations total amount, and preferred content is 5%~25%.
Application of the Shu Min skin care compositions of the present invention in cosmetics, the cosmetics further include customary adjuvant,
The customary adjuvant contains: deionized water, moisturizer, conditioner, thickener, preservative, essence etc..
Application of the Shu Min skin care compositions of the present invention in cosmetics, prepared cosmetics or skin care item preparation
Unlimited setting state, can be made into the form of creme, emulsion, essence lotion, facial mask etc..
The invention has the advantages that and the utility model has the advantages that
Composition source of the invention is natural, it is non-stimulated, have and inhibit itch well, releive skin tender subject and guarantor
Wet effect, and preparation method is easy, is easy to be received by consumer, have good market prospects.The present invention, which can be made into, to wash
The dosage forms such as face milk, cream, lotion, facial mask, various aqua products (toner, smoothing toner, toner, nutritive water, water of releiving).
Detailed description of the invention
Fig. 1 is that the influence of Shu Min essence of the invention with blank control group to allergic skin moisture content compares.
Specific embodiment
Medicinal material used in the present embodiment can be commercially available from China Medicament Group Corp., meet Pharmacopoeia of People's Republic of China
2005 editions standards.Other auxiliary materials can be obtained by commercially available purchase.
Shu Min skin care compositions of the invention, formula in each component specific explanations be described as follows:
Cactus is Cactaceae opuntia, protein rich in, vitamin, carrotene, more than ten kinds
Amino acid necessary to minerals and 18 kinds of amino acid, human bodies nearly all wherein, also containing organic acid, carbohydrate, flavonoids,
Alkaloids, sterols, terpene etc. have the chemical component of stronger pharmacological action.Glue polysaccharide in cactus includes mucus
The heteromeric polysaccharide such as matter, pectin, arabogalactan, cellulose etc., have heat-clearing, removing toxic substances, moisturizing, it is sun-proof the effect of.Chinese medicine
Theory thinks that chylocaulous has the effect of clearing heat and detoxicating, eliminating stasis to subdue swelling, stomach invigorating, analgesia, myogenic apocenosis, the promoting flow of qi and blood circulation.It is civil
The diseases such as common cactus treatment inflammation, pain, pruitus.Cactus extraction has excellent cell function of releiving, to change
General chemical stimulant, UV-induced cellular damage have significant protective effect in cosmetic, can obviously slow down sensitive flesh
Phenomena such as skin common general red, itch, also there is certain repair to ultraviolet light sunburn, to staphylococcus aureus, large intestine
Bacillus etc. has inhibiting effect.
Purslane, alias long life grass, contains protein, fat, carbohydrate, dietary fiber, calcium, phosphorus, iron, copper, Hu Luo
The multiple nutritional components such as Bu Su, vitamin B1, vitamin B2, niacin, vitamin C, especially vitamin A, vitamin C, core
The minerals such as the dimension such as flavine element and calcium, iron.Its omega-fatty acid content account for the first in vegetables with green leaves.According to modern study, purslane
It can inhibit the growth of the various bacterias such as staphylococcus aureus, typhoid bacillus, lipid-metabolism can be improved, inhibit smegma,
Prevention and treatment acne can treat skin sore and furuncle and purulent disease in terms of external application, to eczema, dermatitis rhus, dermatitis, pruitus and pain
Pain has extraordinary curative effect.The primary efficacy of Purslane extract is each of antiallergy, anti-inflammatory anti-inflammatory and the outer bound pair skin of resistance
Kind stimulation, there are also acne-removal functions.The skin allergy that steroids cosmetics generate, which is especially used for a long time, apparent anti-mistake
Quick effect.
Aloe has applied more than 1,000 years in China as medicinal, treats inside and outside tens kinds of section's disease with it, application method
Also varied, such as edible Aloe fresh leaf and fresh juice, take aloe powder, applied outside with the fresh sweat of aloe, aloe leaf outer patch.It is modern
Pharmacological research shows that Aloin A, wound hormone and glycan peptide sweet dew (Ke-2) in aloe etc. have disease-resistant element infection, promotes
Wound healing restore effect, have anti-inflammation and sterilization, heat absorption detumescence, softening skin, keep cell viability function, curdlan and
Traumatic acid joint also has healing wounds activity.The polysaccharide and multivitamin contained in aloe has good battalion to human skin
Feeding, moist, whitening effect.Aloe barbadensis Miller is the Fresh leaf of aloe of the direct beauty of optimum, it have skin contraction, softness,
The performance of moisturizing, anti-inflammatory, bleaching, there are also release hardening, angling, improvement scar effect, can not only prevent small wrinkle, eye pouch,
Cutis laxa, moreover it is possible to keep skin wet, delicate, while can also treat scytitis, to acne, freckle.Acne and scald,
Insect bite etc. also has good curative effect.
Centella has clearing heat and detoxicating, inducing diuresis and reducing edema, nourishing, anti-inflammatory, quelling effect.The centella contained in centella
Glucoside can stimulate deep skin cell to substitute, and compact epidermis and corium coupling part can make skin limber up, and help to solve skin
Relaxation keeps skin smooth flexible；Promote collagen in skin corium to be formed, regenerates fibrin, reconnect
Come, achievees the effect that skin compact smooth.Organization healing and the consolidation skin of wound can also be helped.It can promote epidermis and true
Close connection between skin, and the increase of fat cell can be inhibited, it prevents hydroderma, obesity occur.Centella is suitable for each
Kind skin quality.The Triterpenoid of a- botany bar gum alcohol type is added to cosmetics with calm, stable effect containing there are many in centella
In can help calm skin, alleviate sensitivity phenomenon.
Tremella contains protein, fat and a variety of amino acid, minerals and glycogen, and wherein calcium, the content of iron are very high.This
Outside, also containing glycogen such as trehalose, pentosan, mannitols in tremella, nutritive value is very high, with the work that righting is strong
With being described as " hat in bacterium " by people, be both the strong tonic of rare nutritious tonifying good merchantable brand and righting, have to skin
Beauty, tender skin, it is anti-ageing the effect of.
Shu Min skin care compositions of the invention can also compound other natural plant extracts and active matter to reach and be promoted
The purpose of Shu Min skin effect, and can have moisturizing, Shu Min, anti-inflammatory, the function such as stimulation of releiving by adding other auxiliary material preparations
The cosmetics of energy.As facial cleanser, cream, lotion, facial mask, various aqua products (toner, smoothing toner, toner, nutritive water,
Releive water) etc..
The present invention is further qualified below by way of specific preferred embodiment, single present invention is not limited in reality below
Apply example.
Embodiment 1 (preparation for the sensitive composition that relaxes)
The preparation method of the easypro sensitive composition of the present invention, comprises the following steps that:
1) weighing 60 grams of cactus, 30 grams of purslane, 30 grams of aloe, 20 grams of centella, 30 grams of fresh tremella.
2) 75% ethanol solution of 3 times of the component is added in cactus, purslane, aloe and centella, is placed in 50kHz's
Ultrasound 3 minutes, are crushed to 100 mesh and are uniformly mixed, then be soaked in 75% second of 10 times of corresponding component in ultrasonic cleaning instrument
In alcoholic solution, 4 hours are stood, and under the conditions of 80 DEG C, refluxing extraction 2 hours, stops heating, be cooled to room temperature (25 DEG C), 200
Mesh filtering, obtains filtrate；The 1 of original amount of alcohol is added in filtrate, 3 butanediols are miscible uniformly；1.2 microns of filters are spread in Buchner funnel
Plate；Above-mentioned gained filtrate is filtered by vacuum, collects filtrate to obtain the final product.
Dried tremella extract is made of following methods: the water of 3 times of the tremella quality is added, is placed in 50 and is placed in the super of 50kHz
Sound wave cleans ultrasound 3 minutes in instrument, adds 8 times of tremella quality tremella of the water, and normal heating flows back 3 hours, stops
Heating, is cooled to room temperature (25 DEG C), the filtering of 200 mesh, and filtrate is concentrated, dry to get dried tremella extract.
3) dried tremella extract and the extracting solution of above-mentioned cactus, purslane, aloe and centella are mixed evenly, i.e.,
Must relax sensitive composition.
Embodiment 2 (preparation for the sensitive composition that relaxes)
The preparation method of the easypro sensitive composition of the present invention, comprises the following steps that:
1) weighing 50 grams of cactus, 50 grams of purslane, 50 grams of aloe, 30 grams of centella, 40 grams of fresh tremella.
2) 75% ethanol solution of 3 times of the component is added in cactus, purslane, aloe and centella, is placed in 50kHz's
Ultrasound 3 minutes, are crushed to 100 mesh and are uniformly mixed, then be soaked in 75% ethyl alcohol of 8 times of corresponding component in ultrasonic cleaning instrument
In solution, 3.5 hours are stood, and under the conditions of 80 DEG C, refluxing extraction 2.5 hours, stop heating, be cooled to room temperature (25 DEG C),
The filtering of 200 mesh, obtains filtrate；The 1 of original amount of alcohol is added in filtrate, 3 butanediols are miscible uniformly；Paving 1.2 is micro- in Buchner funnel
Rice filter plate；Above-mentioned gained filtrate is filtered by vacuum, collects filtrate to obtain the final product.
Dried tremella extract is made of following methods: the water of 3 times of the tremella quality is added, is placed in 50 and is placed in the super of 50kHz
Sound wave cleans ultrasound 3 minutes in instrument, adds 8 times of tremella quality tremella of the water, and normal heating flows back 2.5 hours, stops
It only heats, is cooled to room temperature (25 DEG C), filtrate is concentrated in the filtering of 200 mesh, dry to get dried tremella extract.
3) dried tremella extract and the extracting solution of above-mentioned cactus, purslane, aloe and centella are mixed evenly, i.e.,
Must relax sensitive composition.
Embodiment 3 (preparation for the sensitive composition that relaxes)
The preparation method of the easypro sensitive composition of the present invention, comprises the following steps that:
1) weighing 50 grams of cactus, 80 grams of purslane, 20 grams of aloe, 15 grams of centella, 30 grams of fresh tremella.
2) 75% ethanol solution of 3 times of the component is added in cactus, purslane, aloe and centella, is placed in 50kHz's
Ultrasound 3 minutes, are crushed to 100 mesh and are uniformly mixed, then be soaked in 75% second of 10 times of corresponding component in ultrasonic cleaning instrument
In alcoholic solution, 4 hours are stood, and under the conditions of 80 DEG C, refluxing extraction 2 hours, stops heating, be cooled to room temperature (25 DEG C), 200
Mesh filtering, obtains filtrate；The 1 of original amount of alcohol is added in filtrate, 3 butanediols are miscible uniformly；1.2 microns of filters are spread in Buchner funnel
Plate；Above-mentioned gained filtrate is filtered by vacuum, collects filtrate to obtain the final product.
Dried tremella extract is made of following methods: the water of 3 times of the tremella quality is added, is placed in 50 and is placed in the super of 50kHz
Sound wave cleans ultrasound 3 minutes in instrument, adds 8 times of tremella quality tremella of the water, and normal heating flows back 3 hours, stops
Heating, is cooled to room temperature (25 DEG C), the filtering of 200 mesh, and filtrate is concentrated, dry to get dried tremella extract.
3) dried tremella extract and the extracting solution of above-mentioned cactus, purslane, aloe and centella are mixed evenly, i.e.,
Must relax sensitive composition.
Embodiment 4~6 (preparation containing easypro sensitive composition cream)
The present invention contains the cosmetics cream of easypro sensitive composition, see the table below shown in 1 containing following component and dosage.
Table 1: cosmetics cream component and content (weight percent %) containing easypro sensitive composition
Operating procedure is as follows:
1, each raw material in precise A phase heats while stirring to 75-80 DEG C, and mixing speed is 25 turns/min, heat preservation
10min, it is spare；
2, each raw material in precise B phase heats while stirring to 75-80 DEG C, and mixing speed is 25 turns/min, heat preservation
10min, it is spare；
3, B phase raw material being pumped into emulsion pot, temperature is maintained at 80 DEG C, opens homogeneous and stirring, and mixing speed is 35 turns/
A phase is slowly added into B phase by min, after homogeneous 5min, then persistently insulated and stirred 10min；
4, cooling is opened, is stirred to 45 DEG C ± 1 DEG C, C phase is added, mixing speed is adjusted to 20 turns/min, stirs 20min, cold
But to room temperature.
Embodiment 7 (preparation containing easypro sensitive composition essence)
The present invention contains easypro sensitive composition essence, see the table below shown in 2 containing following component and dosage.
Table 2 contains relax sensitive composition essence component and dosage (weight percent %)
| Component | Raw material name | Blank control example (%) | Embodiment 7 (%) |
| A group | Deionized water | TO100 | TO100 |
| 1,3-BDO | 3.0 | 3.0 | |
| Niacinamide | 0.5 | 0.5 | |
| Xanthan gum | 0.2 | 0.2 | |
| Hydroxyethyl cellulose | 0.1 | 0.1 | |
| Allantoin | 0.1 | 0.1 | |
| Dipropylene glycol | 5.0 | 5.0 | |
| Glycerol | 3.0 | 3.0 | |
| B group | Preservative | In right amount | In right amount |
| Essence | In right amount | In right amount | |
| Pigment | In right amount | In right amount | |
| Embodiment 1 is relaxed sensitive composition | 0 | 5.0 |
Operating procedure is as follows:
Each raw material in precise A, B phase opens stirring, puts into each raw material of A phase, and mixing speed is 25 turns/min, stirring
To being completely dissolved, each raw material in B phase is added, stirs 20 minutes, discharging.
Effect experimental examples 1
The evaluation of embodiment 1, embodiment 2, easypro sensitive composition antipruritic effect obtained by embodiment 3:
By calculating submitted sample to the itch-threshold of skin allergy sufferings model, experiment is provided for the antipruritic bacterium effect of evaluation sample
Foundation.Method:
1) given the test agent: embodiment 1, embodiment 2, the sensitive composition that relaxes obtained by embodiment 3 is numbered respectively is A, B, C.
2) it is grouped: taking cavy 60, half male and half female is divided into embodiment 1 and relaxes sensitive composition A large dosage group, middle dose group, low
Dosage group, embodiment 2 are relaxed sensitive composition B large dosage group, middle dose group, low dose group, and embodiment 3 is relaxed sensitive composition C large dosage
Group, middle dose group, low dose group and control group, every group 6.
3) given the test agent is with 0.15ml/1cm2、0.1ml/1cm2、0.5ml/1cm2Partial smearing is as large dosage, middle dosage
It is used with low dose group, control group gives 0.1ml/1cm2Distilled water partial smearing.
4) the right metapedes dorsal body setae hair of cavy is shaved off with depilatory cream, uniformly smears corresponding dosage respectively at shaving for three days on end
By test product, control group gives distilled water smearing.Third day is tested, it is appropriate that precision weighs histamine phosphate, matches before use with distilled water
0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.10% gradient is made
Concentration is spare.It will be abraded at instep shaving behind the cavy right side with coarse sandpaper, area is about 1cm2, it is local to apply again given the test agent 1 time, in
Drip 0.01% histamine phosphate 0.05ml in abrasion after last coating 10min, later every 3min according to 0.01%, 0.02%,
0.03%, 0.04%, 0.05% ... progressive concentration is 0.05ml every time, until cavy occur later licks right metapedes when institute
Dripping the histamine phosphate total amount taken is itch-threshold, calculates each group itch-threshold and compares the otherness between each group.
5) after experimental result is itched using histamine phosphate cause, cavy occurs later licking right metapedes behavior, compared with the control group, relaxes
Sensitive composition A, B, C are remarkably improved cavy histamine phosphate itch-threshold (P < 0.05) (see the table below shown in 3)
Table 3: sample causes the influence (X ± S, n=10) of reaction of itching to cavy histamine phosphate
| Title | Group | Itch-threshold (ug) |
| Control group | - | 58±20.42 |
| Embodiment 1 is relaxed sensitive composition | Large dosage | 118.60±25.22* |
| Embodiment 1 is relaxed sensitive composition | Middle dosage | 100.82±23.25* |
| Embodiment 1 is relaxed sensitive composition | Low dosage | 92.52±26.72* |
| Embodiment 2 is relaxed sensitive composition | Large dosage | 101.81±26.89 |
| Embodiment 2 is relaxed sensitive composition | Middle dosage | 95.96±17.62 |
| Embodiment 2 is relaxed sensitive composition | Low dosage | 82.28±16.04 |
| Embodiment 3 is relaxed sensitive composition | Large dosage | 105.24±24.78 |
| Embodiment 3 is relaxed sensitive composition | Middle dosage | 96.06±18.22 |
| Embodiment 3 is relaxed sensitive composition | Low dosage | 90.72±25.53 |
Note: compared with the control group, * P < 0.05
By the experiment conclusion of table 3 it can be seen that easypro sensitive composition of the invention has very well pruitus after allergy
Antipruritic effect.
Effete test embodiment 2
The clinical evaluation of the Shu Min skin care compositions cream of embodiment 4.
1, test purpose: whether 4 face cream of testing example has Shu Min effect,
2, test crowd: 50, clinical manifestation is that facial skin is sensitive, and itch is uncomfortable, the long-term breaking-out having.
3, test method: double-blind.(the blank control example of easypro sensitive composition is not added in table 1, is hereinafter referred to as comforted
Agent)
4, test period: 28 days.
5, applying amount: during entire test, smearing position is face, and different subject's left and right faces are grouped at random, every one side of something
Face is fixed respectively to smear placebo, and sooner or later primary daily, average applying amount is 2 ㎎/㎡.
6, judgment criteria: (1) cure: clinical symptoms disappear；(2) effectively: clinical symptom relief, skin sensitivity reactive moieties
Subside or disappear, reduce or reduces；(3) invalid: clinical symptoms, skin sensitivity do not improve.
7, result on trial: quick, 1 week effective percentage about 85%, and have certain cure rate, 28 days cure rates are about
72%.There is no an example reaction phenomena such as allergy, skin is uncomfortable occur.
The measure of merit of embodiment 5,6 is the same as embodiment 4.
Effect experimental examples 3
1, test purpose: influence of 7 essence of testing example to allergic skin moisture content.
2, test equipment: German CK company Multi probe skinanalysis apparatus (MPA10) is popped one's head in Corneometer CM825.
3, tested person personnel: face is sensitive skin, dry and red and swollen.
4, test method: test room temperature: 25 ± 1 DEG C, relative humidity: 45%-60%, interior is without accent light or the sun
Light direct irradiation is tested, and tested personnel sits quietly 30 minutes before test in test cabinet, after clear water face cleaning, by embodiment
The essence of 7 preparations is coated on face 30min, and blank control example is smeared on the left side, and the essence for adding the sensitive composition that relaxes is smeared on the right
Element, average applying amount are 2 ㎎/㎡.2, it is popped one's head in again with Corneometer CM825 after 4,6 hours and fixes a position in left and right face
It sets and tests 3 times respectively, take its average value.The same tested person personnel are completed to test by the same staff.
5, test result: being detailed in shown in lower Fig. 1, is largely subsided using red swelling of the skin after Shu Min essence of the invention,
The water content of skin is apparently higher than blank control group, this shows it with good moistening effect.
Claims (6)
1. a kind of Shu Min skin care compositions is preparing the application in cosmetics, which is characterized in that by weight percentage, described to relax
Quick skin care compositions accounts for the 3.3%~41% of cosmetic formulations total amount；It is described by addition based on the weight percent in cosmetics
Shu Min skin care compositions is made of following component:
Cactus extraction 1~10%, Purslane extract 0.3~10%, extract solution from aloe 0.5~10%, centella are extracted
Liquid 0.5~5%, dried tremella extract 1~6%；
The cactus extraction, Purslane extract, extract solution from aloe, centella asiatica extract follow the example of extraction by alcohol extracting；It will
Dried tremella extract and the extracting solution of above-mentioned cactus, purslane, aloe and centella are mixed evenly to get Shu Min skin care group
Close object；
The dried tremella extract is made of following methods:
The water of 3 times of the tremella quality is added, is placed in ultrasound 3 minutes in the ultrasonic cleaning instrument of 50kHz, adds the silver
The water that 8~10 times of ear quality, normal heating flow back 2.5~3.5 hours, stop heating, are cooled to room temperature 25 DEG C, 200~300 mesh
Filtrate is concentrated in filtering, dry to get dried tremella extract.
2. Shu Min skin care compositions according to claim 1 is preparing the application in cosmetics, it is characterised in that:
The cactus extraction, Purslane extract, aloe and the extracting solution of centella are made by following processing step:
1) 75% ethanol solution of 3 times of the component is added in cactus, purslane, aloe and centella, is placed in the ultrasound of 50kHz
Wave cleans ultrasound 3 minutes in instrument, is crushed to 100 mesh and is uniformly mixed, then is soaked in 75% ethyl alcohol of 8~10 times of corresponding component
In solution, 3~4 hours are stood, and under the conditions of 80 DEG C, refluxing extraction 2 hours, stops heating, is cooled to room temperature 25 DEG C, 200
The filtering of~300 mesh, obtains filtrate；
2) 1, the 3- butanediol that original amount of alcohol is added in filtrate is miscible uniformly；1.2 microns of filter plates are spread in Buchner funnel；It will
Above-mentioned gained filtrate is filtered by vacuum, and collects filtrate to obtain the final product.
3. Shu Min skin care compositions according to claim 1 is preparing the application in cosmetics, it is characterised in that: described to relax
Quick skin care compositions is prepared by following processing step:
1) cactus, purslane, aloe, centella, fresh tremella are weighed；
2) 75% ethanol solution of 3 times of the component is added in cactus, purslane, aloe and centella, is placed in the ultrasound of 50kHz
Wave clean instrument in ultrasound 3 minutes, be crushed to 100 mesh and be uniformly mixed, then be soaked in 10 times of corresponding component 75% ethyl alcohol it is molten
In liquid, 4 hours are stood, and under the conditions of 80 DEG C, refluxing extraction 2 hours, stops heating, be cooled to room temperature 25 DEG C, 200 mesh mistakes
Filter, obtains filtrate；The 1,3-BDO that original amount of alcohol is added in filtrate is miscible uniformly；1.2 microns of filter plates are spread in Buchner funnel；
Above-mentioned gained filtrate is filtered by vacuum, collects filtrate to obtain the final product；
Dried tremella extract is made of following methods: the water of 3 times of the tremella quality is added, is placed in the ultrasonic washing instrument of 50kHz
Ultrasound 3 minutes in device add the water of 8 times of the tremella quality, and normal heating flows back 3 hours, stop heating, are cooled to room temperature
25 DEG C, filtrate is concentrated in the filtering of 200 mesh, dry to get dried tremella extract；
3) extracting solution of dried tremella extract and above-mentioned cactus, purslane, aloe and centella is mixed evenly to get relaxing
Quick skin care compositions.
4. Shu Min skin care compositions of any of claims 1-3 is preparing the application in cosmetics, it is characterised in that:
The Shu Min skin care compositions accounts for the 5%~25% of cosmetic formulations total amount.
5. Shu Min skin care compositions according to claim 4 is preparing the application in cosmetics, it is characterised in that: describedization
Cosmetic further includes customary adjuvant, and the customary adjuvant contains: deionized water, moisturizer, conditioner, thickener, preservative, perfume (or spice)
Essence.
6. Shu Min skin care compositions according to claim 4 is preparing the application in cosmetics, it is characterised in that: prepared
Cosmetics creme, emulsion, essence lotion or facial mask form is made.
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| CN106619358A (en) * | 2016-11-15 | 2017-05-10 | 惠州市蕙薏美生物科技有限公司 | Skincare preparation with easing, anti-allergy and repairing effects |
| CN106511177A (en) * | 2016-12-12 | 2017-03-22 | 刚占龙 | Mask |
| CN108653158A (en) * | 2017-03-27 | 2018-10-16 | 上海莱妃化妆品有限公司 | There are the cosmetics and preparation method of auxiliary repair to sensitive skin |
| CN107320382B (en) * | 2017-07-31 | 2018-06-22 | 上海中翊日化有限公司 | A kind of composition containing dried tremella extract and the application in personal care articles |
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| CN110179709A (en) * | 2019-06-19 | 2019-08-30 | 黑龙江润凡生物科技集团有限公司 | A kind of moisturizing Shu Min complex liquid and the preparation method and application thereof |
| CN110538113A (en) * | 2019-09-27 | 2019-12-06 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with moisturizing and hydrating effects and preparation method and application thereof |
| CN110664640A (en) * | 2019-10-17 | 2020-01-10 | 张军 | Plant essence whitening and acne removing essence and preparation method thereof |
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| CN114652763B (en) * | 2020-12-23 | 2023-11-07 | 安琪纽特股份有限公司 | Plant fermentation allergy-relieving composition and preparation method and application thereof |
| CN113041193B (en) * | 2021-03-26 | 2022-03-11 | 北京东方淼森生物科技有限公司 | Anti-irritation composition and preparation method and application thereof |
| CN113081867A (en) * | 2021-04-30 | 2021-07-09 | 正青春祛痘祛斑美容(杭州)有限公司 | Female pudendum anti-aging nourishing gel and preparation method thereof |
| CN116672399A (en) * | 2023-05-17 | 2023-09-01 | 贵州扬生医用器材有限公司 | Centella asiatica pattern micro-emulsion and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100100466A (en) * | 2009-03-06 | 2010-09-15 | 한국콜마 주식회사 | Cosmetic composition for enhancing skin elasticity and improving skin wrinkles and manufacturing method thereof |
| CN103976907A (en) * | 2014-05-29 | 2014-08-13 | 暨南大学 | Cosmetic comprising composition with slow anti-allergic action as well as preparation method and application thereof |
-
2016
- 2016-03-02 CN CN201610118622.3A patent/CN105769654B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100100466A (en) * | 2009-03-06 | 2010-09-15 | 한국콜마 주식회사 | Cosmetic composition for enhancing skin elasticity and improving skin wrinkles and manufacturing method thereof |
| CN103976907A (en) * | 2014-05-29 | 2014-08-13 | 暨南大学 | Cosmetic comprising composition with slow anti-allergic action as well as preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 蔓朵依舒缓修护抗衰复颜蚕丝面膜;国家食品药品监督管理总局;《蔓朵依舒缓修护抗衰复颜蚕丝面膜，网址http://125.35.6.80:8080/ftba/itownet/hzp_ba/fw/pz.jsp?processid=20150104134921igilv&nid=20150104134921igilv》;国产非特殊用途化妆品备案信息服务平台;20150108;第1-2页，第2页成分 |
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Effective date of registration: 20221024 Address after: 515834 Liannan Industrial Zone, Chenghai District, Shantou City, Guangdong Province Patentee after: Guangdong Mingchen Daily Chemical Co.,Ltd. Address before: 515834 Liannan Industrial Zone, Lianxia Town, Chenghai District, Shantou City, Guangdong Province Patentee before: MINGCHEN HEALTH Co.,Ltd. |