WO2018082117A1

WO2018082117A1 - External traditional chinese medicine composition having function of removing red blood in skin and skin care preparation thereof

Info

Publication number: WO2018082117A1
Application number: PCT/CN2016/105803
Authority: WO
Inventors: 张丽云
Original assignee: 惠州市蕙薏美生物科技有限公司
Priority date: 2016-11-03
Filing date: 2016-11-14
Publication date: 2018-05-11
Also published as: CN106362053A

Abstract

Disclosed are an external traditional Chinese medicine composition and a skin care preparation having the function of removing red blood in the skin, and a preparation method therefor. The external traditional Chinese medicine composition is made of safflower, Angelica sinensis, Radix astragali, Ganoderma lucidum, orange peel, Perilla frutescens, Centella asiatica, Smilax glabra, Atractylodes macrocephala, Opuntia dillenii haw and Rhizoma cimicifugae.

Description

External Chinese medicine composition with skin red blood cell function and skin care preparation thereof

The invention belongs to the field of cosmetic skin care, and particularly relates to a topical Chinese medicine composition having the function of removing red blood of the skin and a skin care preparation containing the traditional Chinese medicine composition.

Background technique

The causes of facial redness are complex and diverse, mainly including primary and secondary. People with red bloodshot eyes look redder than normal, which is often called "plateau red" or "red face". This skin is thin and sensitive, and it looks redder when it is too cold, overheated, and emotional. In severe cases, sedimentary stains will form, which not only affects the beauty of the appearance, but also creates a shadow on the mind, which brings great inconvenience to normal life.

The red blood is mostly caused by various damage factors. The epidermal layer of the skin is free of capillaries. The cell nutrition of the epidermis is mainly derived from the third layer of spine in the epidermal layer of our skin. When the acanthosis cells are damaged, the self-supplying ability is reduced, and the skin itself has the ability to repair. At this time, the capillaries of the dermis layer help the acanthocytes to provide nutrients, and expand spontaneously to form red blood.

Currently, methods for treating facial telangiectasia include liquid nitrogen cryotherapy, photon therapy, and laser therapy. Liquid nitrogen cryotherapy is mainly for the case of lighter telangiectasia. This method is not effective and may leave uneven spots. Photon therapy and laser therapy must be performed by highly specialized personnel to completely remove the expanding capillaries, damage the epidermal layer of the skin, and make the skin thin and sensitive. At the same time, if it is a scary body, it will cause a large area of redness damage. Scars are formed with pigmentation and skin damage.

The red bloodshot skin is damaged not only by the epidermis of the skin, but also by capillaries. Therefore, it is necessary to repair the damaged skin epidermis and repair the damaged capillaries at the same time to completely remove the red blood. Most of the skin care products that are used to remove red blood cells are only for repairing the epidermis of the skin, and there are few skin care products for repairing capillaries, so most skin care products can not really solve the problem of red blood.

Summary of the invention

The technical problem to be solved by the present invention is to provide a natural mild and non-irritating herbal skin care preparation which is designed from the perspective of skin health, plant ingredients to assist skin health metabolism, balance skin oil and water ratio, and remove redness. At the same time of bloodshot, the skin as a whole will return to its original healthy and natural state without secondary damage to the skin. Users can use it themselves without professional intervention. Different plant components Repair the damaged skin epidermis, repair damaged capillaries, remove red blood from the roots and do not recur. The technical problem to be solved by the present invention is achieved by the following technical solutions:

A topical Chinese medicine composition having the function of removing red blood of skin, comprising the following components by weight:

20 to 30 servings of safflower, 20 to 30 parts of angelica, 10 to 20 parts of astragalus, 20 to 30 parts of Ganoderma lucidum, 5 to 10 parts of orange peel, 1 to 10 parts of perilla, 20 to 50 parts of Centella asiatica, soil mites 0.5 ~5 parts, 0.1 to 10 parts of Atractylodes, 5 to 10 parts of cactus, 1 to 10 parts of cohosh.

In the above composition, safflower can dredge blood stasis in the capillaries of the red bloodshot skin, relieve red blood erythema symptoms, and repair damaged capillaries.

The ferulic acid contained in Angelica can effectively inhibit the aggregation of platelets. At the same time, Angelica polysaccharide can reduce the redness and swelling of red blood silk skin and increase the elasticity of damaged capillary wall by increasing the proliferation and differentiation of hematopoietic stem cells and improving the hematopoietic microenvironment.

Astragalus polysaccharides, as biomacromolecules, exert different immunomodulatory activities. These immune regulation can regulate the inflammation of red blood skin, effectively alleviate the facial inflammation of red blood and reduce the discomfort of red blood skin wounds.

Ganoderma lucidum can also promote circulation and reduce facial pressure on red blood.

Centella asiatica has a significant role in repairing the epidermis and promotes collagen regeneration. The active ingredient of Centella asiatica can accelerate the healing of wounds, can significantly increase the tensile strength of the tissue, promote keratinization, and stimulate the rapid growth of reticuloendothelial tissue, promote the expression of fibroblast growth factor protein, and repair the damaged table. Cortex.

Cimicifuga, Atractylodes, earthworm, active ingredient in cactus, moisturizing and soothing, relieves the skin inflammation of sensitive red blood, strengthens skin barrier, repairs skin epidermis, and inhibits histamine release from red blood skin.

The above-mentioned external Chinese medicine compositions, each containing a unique plant active ingredient, scientifically match the proportion of each component, and synergistically. Starting from the cause of red bloodshot formation, repairing the damaged epidermis of red blood silk skin, and repairing the damaged capillaries of red blood skin, different plant components for different symptoms of red blood skin, completely solve the problem of red blood.

Further, the steps of the preparation method of the external Chinese medicine composition are as follows:

(1) weighing the bulk drug according to the weight ratio described in the above formula; (2) Put the raw material in boiling water twice, the ratio of the first dose of the drug to water is 1: 15~1:40, the boiling time is 60~180min, and the extract is obtained. The extract obtained by one extraction is filtered out, and the filter residue is added to the water with a weight of 20 to 60 times relative to the weight of the filter residue for boiling, and the boiling time is 60 to 120 minutes to obtain an extract, and the two extracts are combined to obtain a crude extract of the external Chinese medicine composition;

(3) The crude extract is cooled to 22 to 28 ° C, and filtered using a filter cloth of 100 to 200 mesh, and the obtained filtrate is a composition for external use.

A skin care preparation comprising the above-mentioned topical Chinese medicine composition, comprising the above-mentioned external Chinese medicine composition and skin care preparation.

The skin care formulation consists of the following weight percentage components:

0.01 to 5% of oligopeptide

0.1 to 2% of allantoin

0.01~1% ceramide

1 to 10% butanediol

1 to 5% glycerin

0.5 to 3% lecithin

1 to 5% emulsifier

0.01~1% sodium hyaluronate

5~25% topical Chinese medicine composition

2 to 5% of safflower seed oil

2 to 5% of jojoba oil

Add to 100% with water.

Further, the oligopeptide is at least one of oligopeptide-1, oligopeptide-3, oligopeptide-5, and oligopeptide-6. Oligopeptides can be directly absorbed by the skin, enter the epidermal cells, repair damaged collagen fibers of red blood skin, enhance skin elasticity, and repair damaged epidermis. The smaller the molecular weight, the easier the oligopeptide penetrates into the skin and is absorbed by the skin. The oligopeptide is preferably oligopeptide-1 in the present invention.

Further, the ceramide is at least one of ceramide 1, ceramide 2, ceramide 3, and ceramide 6. Ceramide also has the effect of repairing the damaged epidermal layer of red blood cells.

Further, the emulsifier is preferably sorbitan stearate, sorbitol laurate, sucrose coconut oil At least one of an acid ester, dicetyl phosphate, stearyl 2, stearyl 21, cetyl-10 phosphate. These emulsifiers have a special HLB value, and the scientific proportion design can form a unique liquid crystal structure, and the external Chinese medicine composition is encapsulated to form a microcrystalline state. The formed microcrystalline state has a good affinity with human cells, and can smoothly pass through the cell membrane to directly transport the wrapped external Chinese medicine composition to the inside of the cell, thereby improving the absorption efficiency and also contributing to the red bloodshot effect.

Further, the sodium hyaluronate is preferably a small molecular weight sodium hyaluronate having different molecular weights, a medium molecular sodium hyaluronate or a high molecular weight sodium hyaluronate, which can be applied to different parts of the skin to promote skin health.

Further, the skin care preparation is a cream, or an emulsion or a body lotion.

The invention has the following beneficial effects:

The invention starts from the most basic reason for the formation of red blood cells, scientifically matches the proportion of each traditional Chinese medicine component, and cooperates. Repairs the damaged epidermis of red blood skin, restores the natural barrier of the skin, and repairs the damaged capillaries of the red blood skin, which removes red blood from the roots. Safflower, Angelica, Astragalus, Ganoderma lucidum promote facial microcirculation, dredge blood stasis in damaged capillaries, reduce red blood is facial pressure, repair damaged capillaries. Centella asiatica has a significant role in repairing the epidermis, which promotes collagen regeneration and significantly increases the tensile strength of the tissue, thereby repairing the damaged epidermal layer. Cimicifuga, Atractylodes, Earthworm, active ingredient in cactus, moisturizing and soothing, relieves the inflammatory effect of sensitive red blood cells, strengthens the skin barrier, repairs the skin surface layer, inhibits the release of histamine from red blood skin, and completely solves the problem of red blood.

detailed description

The invention is described in detail below with reference to the embodiments, which are merely preferred embodiments of the invention, and are not intended to limit the invention.

Preparation of topical Chinese medicine composition:

(1) Weigh the raw materials by weight: 25 parts of safflower, 25 parts of angelica, 10 parts of astragalus, 20 parts of Ganoderma lucidum, 5 parts of orange peel, 3 parts of perilla, 30 parts of Centella asiatica, 1 part of earthworm, Atractylodes 0.1, Cactus

5 servings, 5 servings of cohosh;

(2) Put the raw material medicine into the boiling water twice, the first weight ratio of the raw material medicine to water is 1:40, the boiling time is 180 minutes, the extract is obtained after filtration, and the filter residue is extracted for the second time. The weight ratio of the filter residue to the water is 1:30, the boiling time is 120 minutes to obtain an extract, and the second extraction liquid is obtained by filtration. Combining the two extracts to obtain a crude extract of the traditional Chinese medicine composition;

(3) The crude extract was cooled to 25 ° C, and filtered using a 150-mesh filter cloth, and the obtained filtrate was a composition for external use.

Table 1: Example 1, 2, 3 cream formula composition

Example 1 Example 2 Example 3 Weight percent Weight percent / Weight 100 Components

Ratio /% to % ratio /% oligopeptide -1 0.1 0 0

Oligopeptide oligopeptide -2 0 2.5 0

Oligopeptide -3 0 0 5

Allantoin

Allantoin 1 0.1 2 Ceramide 1 0.01 0 0

Neural

Ceramide 2 0 0.5 0

Amide

Ceramide 3 0 0 1

Butanediol 1 5 10 alcohol

Glycerin glycerol 2.5 5 1 egg phosphorus

Lecithin 0.5 2.5 3

Lipid

1.5 0 0

Fatty acid ester

Emulsified sorbitol month

1.5 0 0

Citrate

Sucrose coconut oil

0 0 2.5 acid ester Cetyl alcohol

0 0 2.5 phosphate ester

Stearyl alcohol

0 1.5 0

Ether 2

Stearyl alcohol

0 1.5 0

Ether 21

Small molecule

0.01 0.2 0

Sodium hyaluronate

Transparent medium

0.05 0.3 0

Sodium carbonate

Polymer

0 0 1 sodium sulphate

External use

Topical Chinese medicine

Chinese medicine combination 10 5 25

combination

Object

Safflower

Safflower oil 2 3 5

Seed oil

Love love

Jia Jia

Jojoba oil 5 3 2.5 bar oil

Water

Supplement to TolOO TolOO TolOO

The 100% cream preparation process is as follows:

(1) Divided into an aqueous phase and an oil phase according to the water solubility characteristics of each component.

Aqueous phase: water, allantoin, ceramide, butanediol, glycerol, oligopeptide, sodium hyaluronate, topical Chinese medicine composition

Oil phase: lecithin, emulsifier, safflower seed oil, jojoba oil (2) The formulation ratio of water was first added to the preparation vessel, and then the agitation was started, and allantoin, ceramide, butanediol, glycerin, oligopeptide, sodium hyaluronate were uniformly dispersed in water and stirred for 30 minutes.

(3) After stirring for 30 minutes, turn on the heating, the temperature should not exceed 60 °C, and stir for 30 minutes.

(4) Mix the oil phase components evenly, slowly heat to 60 ° C, stir well and set aside.

(5) Add the oil phase to the water phase, start emulsification homogenization, control the homogenization speed and temperature, and the temperature should not exceed 60 °C.

(6) Continue emulsification and stirring for 20 minutes, then stop the emulsification. When stirring and cooling to 25 °C, stop stirring and discharge.

Clinical trial data of Example 1:

1.1 Subjects:

According to different types, 500 women with facial skin red blood between the ages of 14 and 55 years between 2012 and 2015, including 125 cases of hereditary red blood cells, stimulated by the external environment, such as chilling The dry environment stimulated the skin to produce red blood in 125 cases, the use of inferior drugs and cosmetics caused by red blood in 125 cases, the use of hormone ointment caused by red blood in 125 cases.

1.2 Test method:

Each time the patient cleans the skin, the product is applied to the affected area of the skin, gently massaged until the skin is completely absorbed, and the skin surface is kept at least for 30 minutes after the massage. Continuous use for 60 days.

1.3 judgment of efficacy:

Those who have disappeared red blood are cured, and those who eliminate more than 50% have a significant effect. Those who eliminate more than 30% are effective, and those that eliminate 30% or less are not effective.

1.4 test results:

Hereditary telangiectasia: 75 cases were cured, accounting for 60%; 38 cases were significant, accounting for 30.4%; 8 cases were effective, accounting for 6.4%; the effect was not obvious in 5 cases, accounting for 4%.

The external environment stimulated red blood: 120 cases were cured, accounting for 96%; 5 cases were significant, accounting for 4%.

Capillary expansion caused by inferior drugs and cosmetics: 125 cases were cured, accounting for 100%.

Red blood caused by hormonal ointment: 125 cases were cured, accounting for 100%.

1.5 statistical data analysis:

The difficulty of telangiectasia treatment is: hereditary, external environment, poor quality drugs and Caused by cosmetics, caused by hormone ointments.

1.6 Conclusion:

The above clinical trials have shown that the cream of the present invention has significant therapeutic and nourishing effects on red blood cells. Although the effects on various red blood cells are not balanced, the efficiency can be guaranteed above 90%. At the same time, 60 days is used in the test for the skin's two skin metabolic cycles, which lasts for a short period of time. If it lasts for half a year or a year, it is expected to have a better effect, ensuring that all types of red blood cells can be cured. At the same time, the various traditional Chinese medicine plant components selected by the invention are natural and non-toxic, and have good conditioning effect on human skin while removing red blood cells, and assist skin health. The added skin nutrient provides skin nutrition from various angles, promotes skin skin thickening, restores skin's natural barrier, enhances resistance, and fundamentally treats red blood.

The above embodiments are only illustrative of the embodiments of the present invention, and the description thereof is more specific and detailed, but is not to be construed as limiting the invention, but the technical solutions obtained by means of equivalent substitution or equivalent transformation should fall within the present invention. Within the scope of protection.

Claims

Claim

A topical Chinese medicine composition having a function of removing red blood cells from the skin, characterized in that the composition is composed of the following components by weight:

A method for preparing a topical Chinese medicine composition having the function of removing red blood of the skin according to claim 1, wherein the steps are as follows:

(1) weighing the raw material according to the weight ratio according to claim 1;

(2) Put the raw material in boiling water twice, the ratio of the first dose of the drug to water is 1: 15~1:40, the boiling time is 60~180min, and the extract is obtained. The extract obtained by one extraction is filtered out, and the filter residue is added to the water with a weight of 20 to 60 times relative to the weight of the filter residue for boiling. The boiling time is 60 to 120 minutes to obtain a second extract, and the two extracts are combined to obtain a crude extract of the traditional Chinese medicine composition. Object

A topical skin care preparation having a function of removing redness of the skin, characterized in that the skin care preparation comprises the external Chinese medicine composition according to claim 1 and a skin care preparation.

4. An external skin care preparation having a function of removing redness of the skin according to claim 3, wherein the skin care preparation is composed of the following components by weight:

0.01 to 5% of oligopeptide

0.1 to 2% of allantoin

0.01~1% ceramide

1 to 10% butanediol

1 to 5% glycerin

0.5 to 3% lecithin

1 to 5% emulsifier

0.01~1% sodium hyaluronate

5~25% topical Chinese medicine composition 2 to 5% of safflower seed oil

2 to 5% of jojoba oil

Add to 100% with water.

5. The external skin care preparation according to claim 4, wherein the oligopeptide is oligopeptide-1, oligopeptide-3, oligopeptide-5, oligopeptide- At least one of 6.

6. The external skin care preparation according to claim 4, wherein the ceramide is ceramide 1, ceramide 2, ceramide 3, ceramide 6 At least one.

7. The external skin care preparation according to claim 4, wherein the emulsifier is preferably sorbitan stearate, sorbitol laurate, sucrose cocoate At least one of cetyl phosphate, stearyl 2, stearyl 21, cetyl-10 phosphate.

A topical skin care preparation having the function of removing redness of the skin according to claim 4, wherein the skin care preparation is a cream, or an emulsion or a body lotion.