CN106389219A - Externally-used traditional Chinese medicine composition with whitening and freckle removing functions and skin-care preparation - Google Patents
Externally-used traditional Chinese medicine composition with whitening and freckle removing functions and skin-care preparation Download PDFInfo
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- CN106389219A CN106389219A CN201610974380.8A CN201610974380A CN106389219A CN 106389219 A CN106389219 A CN 106389219A CN 201610974380 A CN201610974380 A CN 201610974380A CN 106389219 A CN106389219 A CN 106389219A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention belongs to the field of cosmetics and particularly relates to an externally-used traditional Chinese medicine composition with whitening and freckle removing functions, skin-care preparation and a preparation method of the externally-used traditional Chinese medicine composition. The externally-used traditional Chinese medicine composition comprises nine materials incluiding flos carthami, radix angelicae sinensis, radix astragali, ligusticum wallichii, radix paeoniae alba, rhizoma rehmanniae preparata, radix glycyrrhizae, radix ginseng and rhizoma typhonii and has no simulation to skin after being verified. The nine materials cooperate with one another to facilitate facial microcirculation, assist the skin to metabolize out facial depositions, restrain melanogenesis and decompose formed melanin, so that the externally-used traditional Chinese medicine composition is safe and mild and is capable of brightening the skin, whitening and removing freckles.
Description
Technical field
The invention belongs to cosmetic skin field is and in particular to a kind of have the external medicine composition that whitening and speckle dispelling acts on
And the skin care formulation containing this external medicine composition.
Background technology
In the modern life, whitening and speckle dispelling becomes the topic of an awfully hot door, Hen Duoren gradually, not only includes Ms, very
To being man, all in the effort for skin whitening.
The happening part of speckle mostly be the cheekbone cheek of face, forehead, around eyes, around the nasion and lip etc., these positions
Skin is thin, and subcutaneous fat is few, so being easier to drying, is vulnerable to the infringement of external environment, and skin is easily aging and forms mottle.Have
At the skin of speckle, epidermis is thin, and the appendages of skin and subcutaneous fat are few, and skin aging is very fast, aggravates after Exposure to Sunlight.Speckle is as currently common
One of damage capacitive symptom, though the malaise symptoms such as patient pain, prurituss will not be brought, it has a strong impact on instrument, often gives patient
Bring certain social pressure and mental pressure, this is the problem of the common concern of Medical circle and beauty treatment circle.
At present, the main method processing part spot is laser speckle dispelling, and speckle pigment granule dispersion after laser therapy diminishes,
The migration of basad upper strata, the horny layer coming off also contains pigment granule, and skin corium pigment granule also substantially increases.Liquid nitrogen freezing,
The methods such as attrition, chemical peeling, ruby laser are clinically also widely applied, but, general curative effect is poor, short-term effect
Good, long term then easily recurs, and some treatments have destructive stimulus to skin.A kind of conventional chemical efficiency composition hydroquinone is permissible
Whitening, spot, its curative effect and consumption, relevant using substrate and chemical stability, concentration is all directly proportional to stimulation degree to effect.Hydrogen
Quinone is extremely unstable, and zest is stronger, and long-term high concentration use can cause that blee is uneven, contact dermatitis, exogenous
The symptom such as chloasma and white patch on the face.
Skin of face is dim to improving for Chinese medicinal plant composition, and pigmentation has the advantage of uniqueness, by Chinese medicine, specimen
Take into account comprehensive adjustment, reach the effect of whitening and speckle dispelling skin care, and also have the advantages that toxic and side effects are little, abundant raw material source.
Plant component in Chinese herbal medicine, has the facial lipid peroxidation of opposing, and the facial lipid of protection is not oxidized, resists free radical pair
The infringement of skin histology, effectively suppresses the activity of tryrosinase, can improve facial blood circulation situation simultaneously, promotes face micro-
Circulation, discharges face deposition toxin, pigment, overall bright color, desalinates mottle, skin does not produce drug resistance, nonirritant.
Content of the invention
The technical problem to be solved is to provide a kind of natural gentle no any irritating draft skin care formulation,
From allowing skin health angle design formula, aid in skin recovers normal microcirculation metabolism to this skin care formulation, has for colour of skin dimness
The skin of speckle, stops free radical from generating the colour of skin dimness causing, promotes facial microcirculation, suppression melanin generates, and decomposes simultaneously
The melanin having been formed, discharge face deposition toxin, whitening bright color, on the basis of not damaging skin, Whitening, spot,
Effect also can be more longlasting.
The technical problem to be solved is achieved by the following technical programs：
A kind of external medicine composition with whitening function, is grouped into by the group of following weight：
20～30 parts of Flos Carthami, 10～30 parts of Radix Angelicae Sinensis, 5～10 parts of the Radix Astragali, 5～10 parts of Rhizoma Chuanxiong, 5～10 parts of the Radix Paeoniae Alba, 1～5 part of Radix Rehmanniae Preparata,
1～10 part of Radix Glycyrrhizae, 1～10 part of Radix Ginseng, 1～10 part of Rhizoma Typhonii.
In above-mentioned various compositionss, the active component containing in Flos Carthami can significantly inhibit the activity of TYR enzyme, stops
Melanin generates, and plays whitening function.
Collocation assists suppression tyrosinase activity using Radix Angelicae Sinensis and Rhizoma Chuanxiong, extends the lag time of tryrosinase reaction, suppression
Melanin processed generates.Chinese angelica blood supplementing granulation promoting, Rhizoma Chuanxiong promoting flow of QI and blood, all promote blood circulation of human body, increase endotrophic conveying, reach
To white-skinned face function.
The active component that Radix Ginseng contains equally can promote blood microcirculation, increases skin-nourishing, adjusts skin water oil flat
Weighing apparatus, makes the tender gloss of skin, and Radix Ginseng distinctive active substance ginsenoside is to external tyrosinase activity and B16 melanin
The increment of cell all has suppression, suppresses melanic generation from source.
Licorice active component can decompose the melanin having been formed, and discharges face deposition toxin.
Rhizoma Typhonii and Radix Rehmanniae Preparata all play the role of to remove superoxide ion and free radical, stop the generation of TYR enzyme, play U.S.
White effect.
Nine thing collocation use, synergism, to improve skin, suppression melanin life from all angles of the dark yellow long speckle of skin
Become.
The preparation method of above-mentioned external medicine composition, step is as follows：
（1）Weigh crude drug by the weight of above-mentioned formula；
（2）Crude drug is put in water and decocts water extraction twice, for the first time the part by weight 1 of the crude drug of extraction and water:15～1:
50, decocting time is 60～120min, filters the extracting solution extracting for the first time and obtains filtering residue, and filtering residue adds filtering residue weight 20 relatively
～60 times of water is decocted, and decocting time obtains extracting solution for 60～120min, merges extracting solution twice and obtains external application Chinese medicine group
Compound crude extract；
（3）Cooling crude extract to 25 DEG C, the filter cloth using 100～200 mesh is filtered, the filtrate obtaining, as external application Chinese medicine
Compositionss.
A kind of whitening and skin-protecting preparation containing above-mentioned external medicine composition, by above-mentioned external medicine composition and skin care item
Adjuvant forms.
Further, this skin care formulation is grouped into by the group of following percentage by weight：
0.01～5% beta glucan
0.1～2% pantothenylol
1～5% glycerol
0.01～1% hyaluronate sodium
1～5% liquid crystal type emulsifying agent
5～25% external medicine composition
2～5% safflower oil
0.1～1% Flos Rosae Rugosae quintessence oil
0.01～2% glycyrrhizic acid dipotassium
It is supplemented to 100% with water.
Further, the preferred sorbitan stearate of the emulsifying agent of described liquid crystal type and sorbitan laurate combination, firmly
Lipidol polyethers 2 and stereth 21 combine, sucrose cocounut oil acid esters, dicetyl phosphate and ceteth -10 phosphate ester
Combination, at least one in three kinds of combinations., because having special HLB value, the Proportionality design of science can be with shape for these emulsifying agents
Become unique liquid crystal package structure, wrap up external medicine composition, form microcrystalline state.The microcrystalline state being formed is thin with human body
After birth has good affinity, smoothly can pass through cell membrane, the external medicine composition of parcel is delivered directly to cell
Inside, improves the absorbance of topical composition, accelerates whitening effect.
Further, described skin care formulation is cream, or emulsion or skin cream.
The present invention has the advantages that：
The present invention starts with from freckle removing and whitening the underlying cause and method, the ratio of science nine kinds of Chinese medicinal plant compositions of collocation, association
Same-action, from source, suppression melanin generates, and decomposes the melanin having been formed, and simultaneously facilitates microcirculation and discharges face deposition
Toxin, pigment, bright color.Flos Carthami, Radix Angelicae Sinensis, the active component containing in Rhizoma Chuanxiong, and Radix Ginseng can significantly inhibit TYR enzyme
Activity, stop melanin from generating, play whitening function, simultaneously facilitate blood microcirculation, increase skin-nourishing, adjust skin water
Oil balance.Licorice active component can decompose the melanin having been formed, and discharges face deposition toxin.Rhizoma Typhonii and Radix Rehmanniae Preparata are removed
Superoxide ion and the effect of free radical, stop the generation of TYR enzyme, play whitening function.From the many-sided collocation nine of whitening and speckle dispelling
Plant plant component, simultaneously using the distinctive emulsifying agent that can form liquid crystal structure, including Chinese medicinal plant composition, improve Chinese medicinal plant
Efficiency and absorbance that component cells pass through, the gentle Whitening, spot of safety, non-stimulated have no toxic side effect.
Specific embodiment
With reference to embodiment, the present invention will be described in detail, and embodiment is only the preferred embodiment of the present invention,
It is not limitation of the invention.
Embodiment 1
The preparation of external medicine composition：
（1）Weigh crude drug by weight ratio：20 parts of Flos Carthami, 10 parts of Radix Angelicae Sinensis, the Radix Astragali 10, Rhizoma Chuanxiong 10,6 parts of the Radix Paeoniae Alba, Radix Rehmanniae Preparata 1
Part, 5 parts of Radix Glycyrrhizae, Radix Ginseng 5, Rhizoma Typhonii 5.
（2）Crude drug is put in water and decocts water extraction twice, for the first time the part by weight 1 of the crude drug of extraction and water:
35, decocting time is, 80min, obtains extracting solution, filters the extracting solution extracting for the first time and obtains filtering residue, and filtering residue adds to be filtered relatively
The water that 40 times of slag weight is decocted, decocting time obtains extracting solution for 80min, merges extracting solution twice and obtains external application Chinese medicine group
Compound crude extract；
（3）Cooling crude extract to 25 DEG C, the filter cloth using 100～200 mesh is filtered, the filtrate obtaining, as external application Chinese medicine
Compositionss.
Table 1 cream formula forms
Cream preparation technology is as follows：
（1）It is divided into aqueous phase and oil phase by every kind of component water soluble nature.
Aqueous phase：Water, pantothenylol, glycerol, beta glucan, hyaluronate sodium, external medicine composition, glycyrrhizic acid dipotassium
Oil phase：Emulsifying agent, safflower oil, Flos Rosae Rugosae quintessence oil
（2）It is initially charged the water of formula proportion in preparing container, be then turned on stirring, by pantothenylol, glycerol, beta glucan, hyalomitome
Sour sodium is homogeneously dispersed in water, stirs 30min.
（3）After stirring 30min, open heating, temperature not can exceed that 60 DEG C, stir 30min.
（4）By each for oil phase component mix homogeneously, it is slowly heated to 60 DEG C, stir standby.
（5）Oil phase is added in aqueous phase, starts emulsifying homogeneous, control homogenizing speed and temperature, temperature does not exceed 60
℃.
（6）Stop emulsifying after continuing emulsifying stirring 20min, when continuation stirring is cooled to 25 DEG C, stop stirring discharging.
The clinical trial data of embodiment 1：
1.1 study subject：
By speckle patient between 20 to 55 years old for dissimilar 500 ages selecting during 2012 to 2015, heredity
Property (freckle) 125, metabolic (melanosis) 125, incretion (chloasma) 125, struvite (sunburn) 125.
1.2 test method：
After patient per has cleaned skin, it is coated onto skin using this invention product and corresponds to affected part, be softly massaged into skin complete
Absorb, skin surface after having massaged, at least will be kept to stop 30min.Continuously use 60 days.
1.3 Outcome measure：
All disappearance person is recovery from illness to speckle, and elimination more than 50% person is remarkable result, eliminates more than 30% person for effect effectively, eliminates
Less than 30% person is DeGrain.
1.4 result of the test：
Heritability (freckle)：Recovery from illness 80, accounts for 64%；Remarkable result 40, accounts for 32%；Effective 5, account for 4%；DeGrain 0
Example, accounts for 0%.
Metabolic (melanosis)：Recovery from illness 50, accounts for 40%；Remarkable result 62, accounts for 49.6%, effective example 7, accounts for 5.6%；
DeGrain 0, accounts for 4.8%.
Incretion (chloasma)：Recovery from illness 100, accounts for 80%, remarkable result 20%
Struvite (sunburn)：Recovery from illness 125, accounts for 100%.
1.5 analysis of statistical data：
Whitening and speckle dispelling complexity is followed successively by：Metabolic (melanosis), heritability (freckle), incretion (chloasma), inflammation
Property (sunburn).
1.6 conclusion：
Above-mentioned clinical trial shows, the cream of the present invention has to speckle significantly treats and take good care of effect.Although to various speckle effects
Unbalanced, but effective percentage can ensure that more than 90%.In this test simultaneously using 60 days be two skin metabolism cycles of skin, hold
The continuous time is shorter, if continuing half a year or 1 year it is contemplated that having more preferable effect it is ensured that all types of speckle can be fully recovered,
Skin complete recovery of health state.Meanwhile, the various Chinese medicinal plant compositions that the present invention selects, Nantural non-toxic, in whitening and speckle dispelling
There are good opsonic action, aid in skin health to human body skin simultaneously.The skin-nourishing agent added, can provide from various angles
Skin-nourishing, the health metabolism of skin water and oil balance.
Above example only have expressed embodiments of the present invention, and its description is more concrete and detailed, but it is not intended that
Restriction to invention, as long as the technical scheme being obtained by the way of equivalent or equivalent transformation, all should fall in the present invention
Protection domain within.
Claims (6)
1. a kind of external medicine composition with whitening and speckle dispelling effect is it is characterised in that described compositionss are by following weight portion
The group of proportioning is grouped into：
20～30 parts of Flos Carthami, 10～30 parts of Radix Angelicae Sinensis, 5～10 parts of the Radix Astragali, 5～10 parts of Rhizoma Chuanxiong, 5～10 parts of the Radix Paeoniae Alba, 1～5 part of Radix Rehmanniae Preparata,
1～10 part of Radix Glycyrrhizae, 1～10 part of Radix Ginseng, 1～10 part of Rhizoma Typhonii.
2. external medicine composition described in a kind of claim 1 preparation method it is characterised in that described preparation method step such as
Under：
（1）Weight as described in claim 1 weighs crude drug；
（2）Crude drug is put in water and decocts water extraction twice, for the first time the part by weight 1 of the crude drug of extraction and water:15～1:
50, decocting time is 60～120min, obtains extracting solution, filters the extracting solution extracting for the first time and obtains filtering residue, filtering residue adds phase
20～60 times of water of filtering residue weight is decocted, decocting time is 60～120min, after filtration, obtain second extracting solution, merge
Extracting solution obtains external medicine composition crude extract twice；
（3）Cooling crude extract to 22～28 DEG C, the filter cloth using 100～200 mesh is filtered, the filtrate obtaining, as external
Chinese medicine composition.
3. a kind of external-use skin care preparation with whitening and speckle dispelling effect is it is characterised in that described skin care formulation is by claim 1
Described external medicine composition and skin care item adjuvant composition.
4. according to claim 3 have whitening and speckle dispelling effect external-use skin care preparation it is characterised in that described skin care formulation
It is grouped into by the group of following percentage by weight：
0.01～5% beta glucan
0.1～2% pantothenylol
1～5% glycerol
0.01～1% hyaluronate sodium
1～5% liquid crystal type emulsifying agent
5～25% external medicine composition
2～5% safflower oil
0.1～1% Flos Rosae Rugosae quintessence oil
0.01～2% glycyrrhizic acid dipotassium
It is supplemented to 100% with water.
5. the external-use skin care preparation with whitening and speckle dispelling effect according to claim 4 is it is characterised in that described liquid crystal type
The preferred sorbitan stearate of emulsifying agent and sorbitan laurate combination, stereth -2 and stereth -21 group
Close, sucrose cocounut oil acid esters, dicetyl phosphate and ceteth -10 phosphate ester combine, at least one in three kinds of combinations.
6. the external-use skin care preparation with whitening and speckle dispelling effect according to claim 4 is it is characterised in that described skin protection system
Agent is cream, or emulsion or skin cream.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610974380.8A CN106389219A (en) | 2016-11-07 | 2016-11-07 | Externally-used traditional Chinese medicine composition with whitening and freckle removing functions and skin-care preparation |
| PCT/CN2016/105802 WO2018082116A1 (en) | 2016-11-07 | 2016-11-14 | External traditional chinese medicine composition and skin care preparation having effect of whitening and freckle-removing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610974380.8A CN106389219A (en) | 2016-11-07 | 2016-11-07 | Externally-used traditional Chinese medicine composition with whitening and freckle removing functions and skin-care preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106389219A true CN106389219A (en) | 2017-02-15 |
Family
ID=58015075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610974380.8A Withdrawn CN106389219A (en) | 2016-11-07 | 2016-11-07 | Externally-used traditional Chinese medicine composition with whitening and freckle removing functions and skin-care preparation |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106389219A (en) |
| WO (1) | WO2018082116A1 (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106963684A (en) * | 2017-04-06 | 2017-07-21 | 成都众宜坊农业开发有限公司 | A kind of skin care item of the leaf extract containing Ligusticum wallichii |
| CN107823027A (en) * | 2017-12-26 | 2018-03-23 | 珍尔姿（广州）化妆品有限公司 | A kind of spot-eliminating composition external preparation |
| CN109718184A (en) * | 2019-03-12 | 2019-05-07 | 北温草生物科技(上海)有限公司 | A kind of combined extracts of plant whitening agent |
| CN110314226A (en) * | 2019-08-15 | 2019-10-11 | 广州楚颜化妆品有限公司 | Whitening spot-removing, topical agent of anti-acne and preparation method thereof |
| CN110755338A (en) * | 2019-12-19 | 2020-02-07 | 严志晶 | Whitening functional plant extract composition and preparation method thereof |
| CN112386548A (en) * | 2020-11-13 | 2021-02-23 | 深圳市薇美经典科技发展有限公司 | Freckle-removing skin-brightening preparation and preparation method thereof |
| CN115869225A (en) * | 2022-10-26 | 2023-03-31 | 现代百朗德生物科技(江苏)有限公司 | Peach-red four-ingredient soup cosmetic composition with whitening, antioxidant and anti-wrinkle effects and application of peach-red four-ingredient soup cosmetic composition in cosmetics |
| CN118512502A (en) * | 2024-07-22 | 2024-08-20 | 长春中医药大学 | Traditional Chinese medicine composition for brightening skin color traditional Chinese medicine preparation and preparation method and application thereof |
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| CN110833187A (en) * | 2019-08-23 | 2020-02-25 | 杭州三式化妆品有限公司 | Enzyme stock solution and preparation method thereof |
| CN110393696A (en) * | 2019-09-05 | 2019-11-01 | 张应应 | Dedicated beautifying face and moistering lotion dew of a kind of person in middle and old age and preparation method thereof |
| CN111568828A (en) * | 2020-05-26 | 2020-08-25 | 陈志峰 | Safe, effective and non-side-effect formula and technology for removing freckles and acnes |
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|---|---|---|---|---|
| CN1268318C (en) * | 2004-03-23 | 2006-08-09 | 尹耀成 | Face cream for retaining youthful looks |
| CN102370608A (en) * | 2010-08-06 | 2012-03-14 | 张毅 | Fair complexion powder for face and preparation method thereof |
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2016
- 2016-11-07 CN CN201610974380.8A patent/CN106389219A/en not_active Withdrawn
- 2016-11-14 WO PCT/CN2016/105802 patent/WO2018082116A1/en active Application Filing
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106963684A (en) * | 2017-04-06 | 2017-07-21 | 成都众宜坊农业开发有限公司 | A kind of skin care item of the leaf extract containing Ligusticum wallichii |
| CN107823027A (en) * | 2017-12-26 | 2018-03-23 | 珍尔姿（广州）化妆品有限公司 | A kind of spot-eliminating composition external preparation |
| CN109718184A (en) * | 2019-03-12 | 2019-05-07 | 北温草生物科技(上海)有限公司 | A kind of combined extracts of plant whitening agent |
| CN110314226A (en) * | 2019-08-15 | 2019-10-11 | 广州楚颜化妆品有限公司 | Whitening spot-removing, topical agent of anti-acne and preparation method thereof |
| CN110314226B (en) * | 2019-08-15 | 2023-03-10 | 广州楚颜化妆品有限公司 | External medicament for whitening, removing freckles and acnes and preparation method thereof |
| CN110755338A (en) * | 2019-12-19 | 2020-02-07 | 严志晶 | Whitening functional plant extract composition and preparation method thereof |
| CN112386548A (en) * | 2020-11-13 | 2021-02-23 | 深圳市薇美经典科技发展有限公司 | Freckle-removing skin-brightening preparation and preparation method thereof |
| CN115869225A (en) * | 2022-10-26 | 2023-03-31 | 现代百朗德生物科技(江苏)有限公司 | Peach-red four-ingredient soup cosmetic composition with whitening, antioxidant and anti-wrinkle effects and application of peach-red four-ingredient soup cosmetic composition in cosmetics |
| CN118512502A (en) * | 2024-07-22 | 2024-08-20 | 长春中医药大学 | Traditional Chinese medicine composition for brightening skin color traditional Chinese medicine preparation and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| WO2018082116A1 (en) | 2018-05-11 |
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