CN106265164B - With hair tonic, scalp maintenance, the composition of moisture-keeping efficacy and preparation method thereof - Google Patents
With hair tonic, scalp maintenance, the composition of moisture-keeping efficacy and preparation method thereof Download PDFInfo
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- CN106265164B CN106265164B CN201610836293.6A CN201610836293A CN106265164B CN 106265164 B CN106265164 B CN 106265164B CN 201610836293 A CN201610836293 A CN 201610836293A CN 106265164 B CN106265164 B CN 106265164B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/002—Preparations for repairing the hair, e.g. hair cure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
There is hair tonic, scalp maintenance, composition of moisture-keeping efficacy and preparation method thereof the present invention relates to a kind of.Described composition is made up of the raw material of following percentage by weight meter：Snakegourd extract 0.5~20%, polygala root extract 0.5~12%, camellia flower extract 0.5~10%, five ore deposit peptides 0.2~2%, GP4G 0.2~2%, Prolixir ICE 1~2%, nanoemulsions 1~10%, NMF 1~5%, thickener 0.1~2%, preservative 0.01~1.0%, surplus is deionized water.Wherein, nanoemulsions are prepared from the following materials：Rice chaff oil, octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester, phosphatide, the smooth oleate of sorb, Phenoxyethanol and water.Composition property of the present invention is gentle, non-stimulated, can effectively moisten, conserve hair, and simple with preferable hair tonic, scalp maintenance, moisture-keeping efficacy, and preparation method, cost is relatively low.
Description
Technical field
The present invention relates to daily cosmetics field, and in particular to a kind of to have hair tonic, scalp maintenance, the combination of moisture-keeping efficacy
Thing and preparation method thereof.
Background technology
The abuse of the hairdressing molded products such as the fast pace of modern life, the pressure of work and nervous, hair dyeing and hair-waving with
And the factors such as diet and communication, make depilation phenomenon more and more universal, rejuvenation trend is presented, not only influences beauty, returns
Spirit, the psychology of people produces large effect.Therefore, the research and development of anti-hair loss products more and more by the world medicine with
The attention of cosmetics circle.
Alopecia is common trichonosis, including alopecia areata, alopecia seborrheica, androgenetic alopecia, psychogenic alopecia, old age
Property alopecia and alopecia due to chemotherapy etc., are due to that some factors cause hair especially with alopecia areata and the incidence of disease highest of alopecia seborrheica
Send out the resting stage for entering hair growth too early by growth period, hair follicle and ball top atrophy are changed into thin hair from terminal hair and drawn
Rise.Research shows that alopecia with heredity except having outside the Pass, also with androgen levels, bacterium and fungal infection, endocrine disturbance, nutrition
The factors such as bad, blood vessel microcirculation disorder, stress, stress reaction and drug side-effect are relevant.
Daily cosmetics on phalacrosis prevention and hair generation on the market are a feast for the eyes at present, and most products with the addition of it is more
Chemical substance, rapid-action, effect is obvious, but easily causes more side effect, such as allergic reaction.Therefore, natural activity
The characteristics of hair tonic composition is current research, and as active ingredient of natural plant extraction and separation technology becomes better and approaching perfection day by day, various functions
Property active skull cap components are determined and applied to phalacrosis prevention and hair generation field, for example：Centella, ginseng, Radix Angelicae Sinensis, the tuber of multiflower knotweed, ginkgo, rat-tail
The natural plant extracts such as grass and seaweeds.But these natural component functions are single, to anti-alopecia-stopping, promote the effect of hair tonic not
Significantly, and have the shortcomings that active ingredient preserve unstable, extraction efficiency it is not high.
Chinese patent application 201310379802.3 discloses the hair-loss preventing and hair-restoring hair washing of herbal essences and biochemical composition formula
Dew and preparation method thereof.The hair-loss preventing and hair-restoring shampoo is from modern herbal essences：Artemia extract, hydrolysed rice albumen, hydrolysis
Zein, Semen Pisi sativi extract, extractive of flax seed, pomegranate rind extract, propolis extract, black extract of willow bark, beet
Root extract, mint extract, and modern biochemical composition：People's oligopeptides -11, people's oligopeptides -3, people's oligopeptides -10, copper tripeptides -2, fourth
Spiceleaf stem cell liquid, oat polypeptide, coordinate natural source surfactant：Lauryl glucoside, Plantacare 818, cocounut oil acyl paddy ammonia
Sour sodium, LAA, Quillaia saponaria bark extract are prepared from, and are that a kind of natural, safe and effective hair-loss preventing and hair-restoring is washed
Become visible, but the shampoo formula component is more, and cost is higher.
The content of the invention
It is an object of the invention to provide it is a kind of with hair tonic, scalp maintenance, moisture-keeping efficacy composition, described combination
Physical property matter is gentle, non-stimulated, can effectively moisten, conserve hair, with preferable hair tonic, scalp maintenance, moisture-keeping efficacy, and makes
Preparation Method is simple, and cost is relatively low.
The present invention is by following technical solution to realize above-mentioned purpose：
It is a kind of that there is hair tonic, scalp maintenance, the composition of moisture-keeping efficacy to be made up of the raw material of following percentage by weight meter：Chinese juniper
Building extract 0.5~20%, polygala root extract 0.5~12%, camellia flower extract 0.5~8%, five ore deposit peptides 0.2~2%,
GP4G 0.2~2%, Prolixir ICE 1~2%, nanoemulsions 1~10%, NMF 1~5%, thickener
0.1~2%, preservative 0.01~1.0%, surplus is deionized water.
Preferably, described composition is made up of the raw material of following percentage by weight meter：Snakegourd extract 12%, payta
Extract 8%, camellia flower extract 6%, five ore deposit peptides 1.0%, GP4G 1.5%, Prolixir ICE 2%, nanometer
Emulsion 6%, NMF 3%, thickener 0.5%, preservative 0.2%, surplus is deionized water.
Further, described nanoemulsions are prepared from by the raw material of following percentage by weight meter：Rice chaff oil 5~
10%th, the smooth oleate 1~8% of caprylic/capric triglyceride 1~5%, phosphatidase 1~8%, sorb, the and of Phenoxyethanol 0.1~1%
Water 68~80%.
Preferably, described nanoemulsions are prepared from by the raw material of following percentage by weight meter：Rice chaff oil 8%, octanoic acid
The smooth oleate 5% of triglycerides 3%, phosphatidase 5 %, sorb, Phenoxyethanol 0.2% and water 78.8%.
Further, described NMF is polyalcohols, polysaccharide, natural SP, NMF-50, saualane and pyrrolidines
At least one of keto carboxylic acid sodium；
Described thickener is at least one in xanthan gum, guar gum, carragheen, gellan gum, cellulose, card ripple class
Kind；
Described preservative is dimethyl OIT, imidazolidinyl urea, dimethyloldimethylhydantoin, benzene oxygen
At least one of ethanol, iodine propilolic alcohol butyl mephenesin Carbamate, DMDMH.
In addition, the present invention also provides a kind of preparation method of described composition, comprise the following steps：
(1) take thickener and water to mix, be warming up to 85 DEG C, stir, after material is completely dissolved, be incubated 30min；
(2) 50 DEG C are cooled to, sequentially add snakegourd extract, polygala root extract, camellia flower extract, nanoemulsions and
NMF, 1500~2000r/min homogeneous, 6~12min；
(3) continue to be cooled to 40 DEG C, sequentially add five ore deposit peptides, GP4G, Prolixir ICE and preservative, fill
Divide and stir, produce.
Wherein, the preparation method of the nanoemulsions comprises the following steps：
(1) rice chaff oil, caprylic/capric triglyceride, phosphatide, Phenoxyethanol and the smooth oleate of sorb are mixed, are heated to
70 DEG C, heat while stirring, until material is completely dissolved, it is standby；
(2) water is added in the material after being dissolved toward step (1), under conditions of rotating speed is 500r/min, stirring 3~
5min, prepares thick emulsion；
(3) treat that thick emulsion is cooled to 40 DEG C, by thick emulsion be added to high pressure homogenizer carry out homogeneous, homogenization pressure be 60~
120Mpa, homogenizing time is 10~20min, is cooled to room temperature, produces nanoemulsions.
Wherein, the preparation method of the snakegourd extract comprises the following steps：Fresh snakegourd complete stool is taken to dry, pulverize,
Cross 10~15 mesh sieves, add the ethanol that 8~10 times of amount volume fractions of raw material weight are 70%, add raw material total amount 0.8~
1.2% cellulase, extracts 1~2h, then in 80~90 DEG C of condition 2~3h of refluxing extraction, mistake under the conditions of 38~45 DEG C
Filter, vacuum-concentrcted drying is carried out by filtrate, produces snakegourd extract, it is 5000U/g that the ratio of its cellulase, which is lived,.
Wherein, the preparation method of the polygala root extract comprises the following steps：Fresh payta is taken to dry, pulverize,
10~15 mesh sieves are crossed, coarse powder is placed in supercritical carbon dioxide extraction apparatus, the volume fraction of coarse powder total amount 30~45% is added
For 60~85% ethanol, regulation and control carbon dioxide flow is 15~20L/h, and extracting pressure is 15~20MPa, and extraction temperature is 40
~60 DEG C, extraction time is 1.5~2h, and polygala root extract is made in decompression separation.
Wherein, the preparation method of the camellia flower extract comprises the following steps：Fresh camellia is taken to dry, pulverize,
10~15 mesh sieves are crossed, the ethanol that 8~10 times of amount volume fractions of raw material weight are 70% is added, is continuously carried under the conditions of 60~70 DEG C
Take 2~3 times, 3~4h, is filtered, merging filtrate every time；The CMS adsorbent of filtrate weight 5% is added into filtrate, is stirred
Mix uniform, stand 12h under room temperature condition, be filtered to remove contamination precipitation；The filtered fluid progress vacuum after contamination precipitation will be removed to subtract
Pressure is concentrated and dried, and produces camellia flower extract.
It is of the present invention that there is hair tonic, scalp maintenance, the composition of moisture-keeping efficacy can directly use, can also conduct
Main component is used to prepare the products such as shampoo class, hair conditioner (breast) class, hair-care essence liquid class.
Composition of the present invention with hair tonic, scalp maintenance, moisture-keeping efficacy is extracted with snakegourd extract, payta
Thing and camellia flower extract are used as main active.Wherein, snakegourd extract is rich in triterpenoid saponin, alkaloid, flavones, polysaccharide
Etc. active ingredient, with significant bacteriostasis, there are preferable inhibition, and expansible blood vessel to bacterium and fungi, change
Kind microcirculation, increases CBF.Described polygala root extract be rich in saponins, mouth mountain ketone and oligosaccharides ester, with intelligence promoting and tranquilization,
Tranquilizing soporific, antibacterial anti-inflammatory, anti-oxidant, anti-aging effect.Described camellia flower extract is rich in Tea Polyphenols, total saposins, total
Flavones and vitamin B1, B2, the effect with significant anti-oxidant, anti-inflammation, regulating blood flow amount, the Tea Polyphenols being rich in is to 5-
Alpha-reductase has significant inhibitory action, can adjust hormonal readiness, suppresses the secretion of sebaceous glands, the vitamin B1 and B2 being rich in
It is cell biooxidation and the coenzyme of energetic supersession, development and cytothesis can be promoted.It is of the present invention that there is hair tonic, scalp
Maintenance, the composition comprehensive utilization snakegourd extract of moisture-keeping efficacy, effect of polygala root extract and camellia flower extract, from changing
Kind microcirculation, anti-inflammation suppresses 5- alpha-reductases, promotes multiple angles such as cytothesis to set out, gives full play to hair tonic, scalp
Maintenance, effect of moisturizing.
In addition, of the present invention there is hair tonic, scalp maintenance, the composition of moisture-keeping efficacy to be aided with five ore deposit peptides of addition, four
Di(2-ethylhexyl)phosphate guanosine, Prolixir ICE, from nutrition mechanism is recovered, assign hair root living, the angle for nourishing hair matricyte and hair is set out,
Scalp is moistened, promotes the regeneration and growth of hair.Wherein, five described ore deposit peptides are active mineral yeast polypeptides, are mineral member
Zinc, copper, magnesium, iron and the silicon of element and the complex compound of yeast polypeptides formation, specially yeast polypeptides complexing, purchased from U.S.'s Chinese mugwort orange red science and technology
Company (Active Concepts), it is micro- directly to skin (hair) supplement with closest to the existence form of human body mineral element
Mineral element is measured, is quickly absorbed, the smooth hair hair scale piece of energy, can releive the hair chemically and physically damaged.
Described GP4G (GP4G), is a kind of cellular energy element extracted from halomereid, is purchased from
American International Specialty Products Company (ISP), can supplement energy to cell rapidly, activate the various physiological activities of Skin Cell and new old generation
Thank, and the function of protecting and repair with DNA.
Described Prolixir ICE are the proteasome factor living only, from hydrolysed rice albumen, purchased from Ya Shilan China
(ASHLAND), by maintaining proteasome to act on, Protein Damage is reduced, improves the various enzymatic activitys relevant with hair growth
It is abnormal, promote hair growth.
It is of the present invention that there is hair tonic, scalp maintenance, the composition of moisture-keeping efficacy to be aided with addition nanoemulsions, it is described
Nanoemulsions are a kind of nano-colloids for the individual layer membrane structure being made up of lecithin and cosurfactant with certain proportion,
Can be miscible with the transparent system such as water, breast, in skin surface formation closed effect, increase skin moisture-keeping performance, and receive with unique
Rice biological effect, effectively improves the stability of active component in composition, and promotes active component diffusion to pass through skin keratin
Layer, is absorbed or fused by epidermal cell, gives full play to effect of active component.
Compared with prior art, beneficial effects of the present invention are：
(1) the composition each component of the present invention with hair tonic, scalp maintenance, moisture-keeping efficacy is mutually coordinated, mutually
Gain, from microcirculation is improved, anti-inflammation suppresses 5- alpha-reductases, promotes multiple angles such as cytothesis to set out, give full play to
Hair tonic, scalp maintenance, effect of moisturizing, and from nutrition mechanism is recovered, hair root living is assigned, the angle for nourishing hair matricyte and hair goes out
Hair, moistens scalp, promotes the regeneration and growth of hair.
(2) present invention is by adding appropriate nanoemulsions, using the unique nanobiology effect of nanoemulsions, effectively
Improve the stability of active component in composition, and promote active component to penetrate into scalp cells, with give full play to activity into
The effect divided.
(3) the composition property of the present invention with hair tonic, scalp maintenance, moisture-keeping efficacy is gentle, without any bad
Stimulate and side effect, using effect is significantly, safe and reliable, and preparation method is simple, cost is relatively low.
Embodiment
The present invention is further described below by way of embodiment, but the present invention is not limited only to following examples.
The preparation of the nanoemulsions of embodiment 1
The formula of A-E group nanoemulsions see the table below：
| Component | A groups | B groups | C groups | D groups | E groups |
| Rice chaff oil (%) | 5 | 10 | 8 | 6 | 10 |
| Trivent OCG (%) | 5 | / | 3 | / | 5 |
| Triglyceride DDD (%) | / | 1 | / | 5 | / |
| Phosphatide (%) | 8 | 1 | 5 | 6 | 8 |
| The smooth oleate of sorb (%) | 1 | 8 | 5 | 4 | 8 |
| Phenoxyethanol (%) | 1 | 0.1 | 0.2 | 0.5 | 1 |
| Water (%) | 80 | 79.9 | 78.8 | 78.5 | 68 |
Preparation method：
(1) rice chaff oil, caprylic/capric triglyceride, phosphatide, Phenoxyethanol and the smooth oleate of sorb are mixed, are heated to
70 DEG C, heat while stirring, until material is completely dissolved, it is standby；
(2) water is added in the material after being dissolved toward step (1), under conditions of rotating speed is 500r/min, 4min, system is stirred
Standby thick emulsion；
(3) treat that thick emulsion is cooled to 40 DEG C, thick emulsion is added into high pressure homogenizer carries out homogeneous, and homogenization pressure is
80Mpa, homogenizing time is 15min, is cooled to room temperature, produces nanoemulsions.
The nanoemulsions quality testing of embodiment 2
Received using laser particle analyzer (Britain, Malvern instrument) nanometer ZS90 by the way that dynamic light scattering is obtained to A-E groups
Rice milk liquid average grain diameter and size distribution are measured.Determined in a fixed angle is 173 DEG C of sample cell, the liquid of emulsion
Drop size is the average diameter for describing accumulation measured value.Polydispersity index (the Polymer of size distribution particle diameter
Dispersity index, PDI) description.It the results are shown in Table 1.
The average grain diameter and PDI of the nanoemulsions of table 1
| Index | A groups | B groups | C groups | D groups | E groups |
| Average grain diameter (nm) | 25.84 | 23.16 | 20.15 | 27.40 | 29.56 |
| PDI | 0.13 | 0.12 | 0.11 | 0.14 | 0.15 |
PDI represents the particle diameter distribution of drop in system, and its value is smaller, represents that particle size dispersion is more single, as seen from the above table, C
The average grain diameter and PDI of the obtained nanoemulsions of group are minimum, better quality, therefore of the present invention there is hair tonic, scalp to repair
Shield, the composition of moisture-keeping efficacy are prepared using nanoemulsions made from C groups as raw material.
Embodiment 3 has hair tonic, scalp maintenance, the preparation of the composition of moisture-keeping efficacy
The embodiment of the present invention 3 have hair tonic, scalp maintenance, moisture-keeping efficacy composition by following percentage by weight meter original
Material composition：Snakegourd extract 12%, polygala root extract 8%, camellia flower extract 6%, five ore deposit peptides 1.0%, four di(2-ethylhexyl)phosphate birds
Glycosides 1.5%, Prolixir ICE 2%, nanoemulsions 6%, NMF 3%, thickener 0.5%, preservative 0.2%, surplus is
Deionized water.
Preparation method：
(1) preparation of snakegourd extract：Take fresh snakegourd complete stool dry, pulverize, cross 15 mesh sieves, add raw material weight 10
The ethanol that amount volume fraction is 70% again, adds the cellulase of raw material total amount 1.2%, 2h is extracted under the conditions of 45 DEG C, so
Afterwards in 90 DEG C of condition refluxing extraction 3h, filtrate is carried out vacuum-concentrcted drying, produces snakegourd extract by filtering, wherein fine
It is 5000U/g that the ratio of the plain enzyme of dimension, which is lived,.
(2) preparation of polygala root extract：Take fresh payta dry, pulverize, cross 15 mesh sieves, coarse powder is placed in super face
In boundary's carbon dioxide extraction apparatus, the ethanol that the volume fraction of coarse powder total amount 45% is 60% is added, regulation and control carbon dioxide flow is
20L/h, extracting pressure is 20MPa, and extraction temperature is 40 DEG C, and extraction time is 2h, and polygala root extract is made in decompression separation.
(3) preparation of camellia flower extract：Take fresh camellia floral leaf dry, pulverize, cross 15 mesh sieves, add raw material weight
The ethanol that 10 times of amount volume fractions are 70%, continuous under the conditions of 70 DEG C to extract 3 times, each 3h, filtering, merging filtrate；Toward filter
The adsorbent of filtrate weight 5% is added in liquid, is stirred, is stood 12h under room temperature condition, be filtered to remove contamination precipitation；It will remove
Filtered fluid after decontamination precipitation carries out vacuum-concentrcted drying, produces camellia flower extract.
(4) preparation of anti-shed hair growth liquid：
1. take thickener and water to mix, be warming up to 85 DEG C, stir, after material is completely dissolved, be incubated 30min；
2. 50 DEG C are cooled to, sequentially add snakegourd extract, polygala root extract, camellia flower extract, nanoemulsions and
NMF, 2000r/min homogeneous 6min；
3. continue to be cooled to 40 DEG C, sequentially add five ore deposit peptides, GP4G, Prolixir ICE and preservative, fill
Divide and stir, produce.
Embodiment 4 has hair tonic, scalp maintenance, the preparation of the composition of moisture-keeping efficacy
The embodiment of the present invention 4 have hair tonic, scalp maintenance, moisture-keeping efficacy composition by following percentage by weight meter original
Material composition：Snakegourd extract 20%, polygala root extract 0.5%, camellia flower extract 8%, five ore deposit peptides 2%, four di(2-ethylhexyl)phosphate birds
Glycosides 0.2%, Prolixir ICE 1%, nanoemulsions 10%, NMF 5%, thickener 2%, preservative 0.01%, surplus is
Deionized water.
Preparation method：
(1) preparation of snakegourd extract：Take fresh snakegourd complete stool dry, pulverize, cross 10 mesh sieves, add raw material weight 8
The ethanol that amount volume fraction is 70% again, adds the cellulase of raw material total amount 0.8%, 1h is extracted under the conditions of 38 DEG C, so
Afterwards in 80 DEG C of condition refluxing extraction 2h, filtrate is carried out vacuum-concentrcted drying, produces snakegourd extract by filtering, wherein fine
It is 5000U/g that the ratio of the plain enzyme of dimension, which is lived,.
(2) preparation of polygala root extract：Take fresh payta dry, pulverize, cross 10 mesh sieves, coarse powder is placed in super face
In boundary's carbon dioxide extraction apparatus, the ethanol that the volume fraction of coarse powder total amount 30% is 85% is added, regulation and control carbon dioxide flow is
15L/h, extracting pressure is 15MPa, and extraction temperature is 60 DEG C, and extraction time is 1.5h, and payta extraction is made in decompression separation
Thing.
(3) preparation of camellia flower extract：Take fresh camellia floral leaf dry, pulverize, cross 10 mesh sieves, add raw material weight
The ethanol that 8 times of amount volume fractions are 70%, continuous under the conditions of 60 DEG C to extract 2 times, each 4h, filtering, merging filtrate；Toward filtrate
The middle adsorbent for adding filtrate weight 5%, stirs, stands 12h under room temperature condition, be filtered to remove contamination precipitation；It will remove
Filtered fluid after contamination precipitation carries out vacuum-concentrcted drying, produces camellia flower extract.
(4) preparation of anti-shed hair growth liquid：
1. take thickener and water to mix, be warming up to 85 DEG C, stir, after material is completely dissolved, be incubated 30min；
2. 50 DEG C are cooled to, sequentially add snakegourd extract, polygala root extract, camellia flower extract, nanoemulsions and
NMF, 1500r/min homogeneous 12min；
3. continue to be cooled to 40 DEG C, sequentially add five ore deposit peptides, GP4G, Prolixir ICE and preservative, fill
Divide and stir, produce.
Embodiment 5 has hair tonic, scalp maintenance, the preparation of the composition of moisture-keeping efficacy
The embodiment of the present invention 5 have hair tonic, scalp maintenance, moisture-keeping efficacy composition by following percentage by weight meter original
Material composition：Snakegourd extract 8%, polygala root extract 12%, camellia flower extract 0.5%, five ore deposit peptides 0.6%, four di(2-ethylhexyl)phosphates
Guanosine 2%, Prolixir ICE 1.5%, nanoemulsions 4%, NMF 2%, thickener 1%, preservative 1%, surplus are to go
Ionized water.
Preparation method reference implementation example 3.
Embodiment 6 has hair tonic, scalp maintenance, the preparation of the composition of moisture-keeping efficacy
The embodiment of the present invention 6 have hair tonic, scalp maintenance, moisture-keeping efficacy composition by following percentage by weight meter original
Material composition：Snakegourd extract 0.5%, polygala root extract 6%, camellia flower extract 2%, five ore deposit peptides 0.2%, four di(2-ethylhexyl)phosphate birds
Glycosides 1%, Prolixir ICE 1%, nanoemulsions 1%, NMF 1%, thickener 0.1%, preservative 0.5%, surplus are to go
Ionized water.
Preparation method reference implementation example 3.
Comparative example 1 has hair tonic, scalp maintenance, the preparation of the composition of moisture-keeping efficacy
Comparative example 1 of the present invention have hair tonic, scalp maintenance, moisture-keeping efficacy composition by following percentage by weight meter original
Material composition：Snakegourd extract 12%, polygala root extract 8%, camellia flower extract 6%, five ore deposit peptides 1.0%, four di(2-ethylhexyl)phosphate birds
Glycosides 1.5%, Prolixir ICE 2%, NMF 3%, thickener 0.5%, preservative 0.2%, surplus is deionized water.
Preparation method reference implementation example 3, the difference of this comparative example and embodiment 3 is without nanoemulsions.
Comparative example 2 has hair tonic, scalp maintenance, the preparation of the composition of moisture-keeping efficacy
Comparative example 2 of the present invention have hair tonic, scalp maintenance, moisture-keeping efficacy composition by following percentage by weight meter original
Material composition：Polygala root extract 12%, camellia flower extract 8%, five ore deposit peptides 1.0%, GP4G 1.5%,
Prolixir ICE 2%, nanoemulsions 6%, NMF 3%, thickener 0.5%, preservative 0.2%, surplus is deionization
Water.
Preparation method reference implementation example 3, the difference of this comparative example and embodiment 3 is without snakegourd extract, and phase
The ratio of polygala root extract and camellia flower extract should be increased.
Comparative example 3 has hair tonic, scalp maintenance, the preparation of the composition of moisture-keeping efficacy
Comparative example 3 of the present invention have hair tonic, scalp maintenance, moisture-keeping efficacy composition by following percentage by weight meter original
Material composition：Snakegourd extract 12%, polygala root extract 8%, camellia flower extract 6%, five ore deposit peptides 1.0%, Prolixir
ICE 2%, nanoemulsions 6%, NMF 3%, thickener 0.5%, preservative 0.2%, surplus is deionized water.
Preparation method reference implementation example 3, the difference of this comparative example and embodiment 3 is without GP4G.
Comparative example 4 has hair tonic, scalp maintenance, the preparation of the composition of moisture-keeping efficacy
Comparative example 4 of the present invention have hair tonic, scalp maintenance, moisture-keeping efficacy composition by following percentage by weight meter original
Material composition：Snakegourd extract 12%, polygala root extract 8%, camellia flower extract 6%, five ore deposit peptides 1.0%, four di(2-ethylhexyl)phosphate birds
Glycosides 1.5%, nanoemulsions 6%, NMF 3%, thickener 0.5%, preservative 0.2%, surplus is deionized water.
Preparation method reference implementation example 3, the difference of this comparative example and embodiment 3 is without Prolixir ICE.
Test example one, skin irritation test
100 volunteers are screened, at 20~50 years old age, men and women half and half, all volunteers test position without dermatopathy
Skin it is completely normal.According to Ministry of Health of the People's Republic of China《Cosmetics health specification (2002 editions)》Middle human body skin patch
The basic principle and method of experiment, to having hair tonic, scalp maintenance, moisturizing made from 3-6 of the embodiment of the present invention and comparative example 1-4
The composition of effect carries out the note experiment of human body skin class, is specially：Composition is diluted to 1% aqueous solution, given the test agent is used as；
Take 0.025ml sample drops to be added on appended by spot examination device on filter paper with syringe, be placed in spot examination device.Spot examination device is affixed on subject
Back, while light pressing room and is uniformly distributed trier to drive away air one by one, is removed after given the test agent, 30min after 24h
Result, 24h, 48h repeated observation are observed, and makees blank control.
Wherein skin irritation test standard of perfection is：0 grade：It is non-stimulated, without erythema；1 grade：Slight erythema；2 grades：Erythema；
3 grades：Erythema, papule, blister；4 grades：Serious edema, bulla, the results are shown in Table 1.
The present invention of table 1 has hair tonic, scalp maintenance, the Skin Irritation Test result of the composition of moisture-keeping efficacy
| Group | Phenomenon |
| Blank control | It is non-stimulated, without erythema |
| Embodiment 3 | It is non-stimulated, without erythema |
| Embodiment 4 | It is non-stimulated, without erythema |
| Embodiment 5 | It is non-stimulated, without erythema |
| Embodiment 6 | It is non-stimulated, without erythema |
| Comparative example 1 | It is non-stimulated, without erythema |
| Comparative example 2 | It is non-stimulated, without erythema |
| Comparative example 3 | It is non-stimulated, without erythema |
| Comparative example 4 | It is non-stimulated, without erythema |
As a result show, the composition with hair tonic, scalp maintenance, moisture-keeping efficacy that the present invention is provided is non-stimulated to skin,
Erythema will not be caused, it is safe.
Test example two, the experiment of phalacrosis prevention and hair generation effect assessment
The alopecia seborrheica volunteer patients and each 450 of alopecia areata volunteer patients of screening clinical definite, 25~55 years old age, its
In, male's alopecia seborrheica volunteer patients 360, women alopecia seborrheica volunteer patients 90；Male's alopecia areata volunteer patients 315
Example, women alopecia areata volunteer patients 135.Alopecia seborrheica volunteer patients and alopecia areata volunteer patients are randomly divided into control respectively
Group, embodiment 3-6 groups and comparative example 1-4 groups, every group 50.Wherein, control group gives commercially available overlord's hair nourishing liquid, takes every time about
5mL, is uniformly applied to volunteer patients' alopecia position, and suitably massage to promote to absorb, 1~2 times/day；Embodiment 3-6 groups and right
Ratio 1-4 groups give volunteer patients respectively using what 3-6 of the embodiment of the present invention and comparative example 1-4 was provided there is hair tonic, scalp to repair
Shield, the composition of moisture-keeping efficacy, 1~2 times/day, about 2mL, by Zu compound Tu Droplets at the position for needing hair tonic, is then massaged every time
5min, then washed off with clear water, it was 1 course for the treatment of with 2 months, persistently using 2 courses for the treatment of, observes curative effect.
The standard of curative effect evaluation is：1) fully recover：Hair stopping, which comes off, newly hair is whole grows, its distribution density, thickness, color and luster
Identical with Jian Fa areas, sebum secretion recovers normal.2) it is effective：Hair stops coming off, and new hair regeneration is up to more than 70%, and its distribution is close
Degree, thickness, color and luster are significantly reduced close to Jian Fa areas, sebum secretion.3) effectively：Hair stops coming off, new hair regeneration up to 30% with
On, including fine hair on birds or animals hair and white hair grow.4) it is invalid：New hair regeneration is less than 30% or continues to take off originator.It the results are shown in Table 2 and 3.
Phalacrosis prevention and hair generation effect of the present composition of table 2 to alopecia seborrheica volunteer patients
Phalacrosis prevention and hair generation effect of the present composition of table 3 to alopecia areata volunteer patients
| Group | Cure | It is effective | Effectively | It is invalid | Efficient (%) |
| Control group | 15 | 21 | 7 | 7 | 86 |
| Embodiment 3 | 17 | 21 | 7 | 5 | 90 |
| Embodiment 4 | 15 | 23 | 6 | 6 | 88 |
| Embodiment 5 | 13 | 21 | 8 | 8 | 84 |
| Embodiment 6 | 11 | 19 | 10 | 10 | 80 |
| Comparative example 1 | 7 | 10 | 13 | 20 | 60 |
| Comparative example 2 | 9 | 15 | 12 | 14 | 72 |
| Comparative example 3 | 11 | 18 | 9 | 12 | 76 |
| Comparative example 4 | 12 | 16 | 10 | 12 | 76 |
As a result show, composition made from 3-6 of the embodiment of the present invention is suffered to alopecia seborrheica volunteer patients and alopecia areata aspiration
Person is respectively provided with preferable phalacrosis prevention and hair generation effect, efficient up to more than 80%, wherein, composition is to fat made from embodiment 3 and 4
The phalacrosis prevention and hair generation effect of excessive property alopecia volunteer patients and alopecia areata volunteer patients are superior to commercially available overlord's hair nourishing liquid.And comparative example 1-4
The effect of obtained composition phalacrosis prevention and hair generation substantially weakens, especially worst with composition phalacrosis prevention and hair generation effect made from comparative example 1.
Test example three, the experiment of scalp care efficacy assessments
Screen the trial volunteer of 450 problems of itching with dandruff, head, wherein 25~55 years old age, male 180, female
Property 270.Trial volunteer is randomly divided into control group, embodiment 3-6 groups and comparative example 1-4 groups, every group 50.Control group is given
Commercially available Paris L'Oreal hyaluronic acid anti-dandruff shampoo is given, about 1mL is taken every time, hair is uniformly applied to, and suitably massages to promote
Enter to absorb, then cleaned with clear water, 1 times/day；Embodiment 3-6 groups and comparative example 1-4 groups give 3-6 of the embodiment of the present invention respectively
The composition provided with comparative example 1-4, daily external application 1 time, about 1mL, is uniformly applied to hair, and suitably press by composition every time
Rub to promote to absorb, then cleaned with clear water, it is continuous to use 15, evaluate dandruff and head is itched improvement situation, the results are shown in Table 4.
The present composition scalp care effect assessment result of table 4
As a result show, composition made from 3-6 of the embodiment of the present invention has preferable hair nursing effect, can substantially reduce
Dandruff and head are itched, and its effect is superior to commercially available Paris L'Oreal hyaluronic acid anti-dandruff shampoo, and dandruff and head will not be caused to itch increasing
Plus.And the effect of composition hair nursing made from comparative example 1-4 substantially weakens, especially with composition head made from comparative example 1
Send out nursing efficacy worst.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (9)
1. a kind of have hair tonic, scalp maintenance, the composition of moisture-keeping efficacy, it is characterised in that described composition is by following heavy
Measure the raw material composition of percentages：Snakegourd extract 0.5 ~ 20%, polygala root extract 0.5 ~ 12%, camellia flower extract 0.5 ~
8%th, five ore deposit peptides 0.2 ~ 2%, GP4G 0.2 ~ 2%, Prolixir ICE 1 ~ 2%, nanoemulsions 1 ~ 10%, NMF 1 ~
5%th, thickener 0.1 ~ 2%, preservative 0.01 ~ 1.0%, surplus is deionized water；
Described nanoemulsions are prepared from by the raw material of following percentage by weight meter：Rice chaff oil 5 ~ 10%, caprylic/capric glycerine
The smooth oleate 1 ~ 8% of three esters 1 ~ 5%, phosphatidase 1 ~ 8%, sorb, Phenoxyethanol 0.1 ~ 1% and water 68 ~ 80%；
Five described ore deposit peptides are active mineral yeast polypeptides, are yeast polypeptides complexing zinc, copper, magnesium, iron and the complex compound of silicon formation.
2. according to claim 1 have hair tonic, scalp maintenance, the composition of moisture-keeping efficacy, it is characterised in that described
Composition is made up of the raw material of following percentage by weight meter：Snakegourd extract 12%, polygala root extract 8%, camellia flower extract
6%th, five ore deposit peptides 1.0%, GP4G 1.5%, Prolixir ICE 2%, nanoemulsions 6%, NMF 3%, thickener
0.5%th, preservative 0.2%, surplus is deionized water.
3. according to claim 1 have hair tonic, scalp maintenance, the composition of moisture-keeping efficacy, it is characterised in that described
Nanoemulsions are prepared from by the raw material of following percentage by weight meter：Rice chaff oil 8%, Trivent OCG 3%, phosphatidase 5 %, sorb
Smooth oleate 5%, Phenoxyethanol 0.2% and water 78.8%.
4. according to claim 1 or 2 have hair tonic, scalp maintenance, the composition of moisture-keeping efficacy, it is characterised in that
Described NMF is in polyalcohols, polysaccharide, natural SP, NMF-50, saualane and pyrrolidone sodium carboxylate
It is at least one；
Described thickener is at least one of xanthan gum, guar gum, carragheen, gellan gum, cellulose, card ripple class；
Described preservative is dimethyl OIT, imidazolidinyl urea, dimethyloldimethylhydantoin, benzene oxygen second
At least one of alcohol, iodine propilolic alcohol butyl mephenesin Carbamate, DMDMH.
5. according to claim 1 have hair tonic, scalp maintenance, the composition of moisture-keeping efficacy, it is characterised in that described group
The preparation method of compound comprises the following steps：
（1）Take thickener and water to mix, be warming up to 85 DEG C, stir, after material is completely dissolved, be incubated 30min；
（2）50 DEG C are cooled to, snakegourd extract, polygala root extract, camellia flower extract, nanoemulsions and moisturizing is sequentially added
Agent, 1500 ~ 2000r/min homogeneous, 6 ~ 12min；
（3）Continue to be cooled to 40 DEG C, sequentially add five ore deposit peptides, GP4G, Prolixir ICE and preservative, fully stir
Mix uniform, produce.
6. according to claim 5 have hair tonic, scalp maintenance, the composition of moisture-keeping efficacy, it is characterised in that described to receive
The preparation method of rice milk liquid comprises the following steps：
（1）Rice chaff oil, caprylic/capric triglyceride, phosphatide, Phenoxyethanol and the smooth oleate of sorb are mixed, 70 DEG C are heated to,
Heat while stirring, until material is completely dissolved, it is standby；
（2）Toward step（1）Water is added in material after dissolving, under conditions of rotating speed is 500r/min, 3 ~ 5min is stirred, prepares
Thick emulsion；
（3）Treat that thick emulsion is cooled to 40 DEG C, by thick emulsion be added to high pressure homogenizer carry out homogeneous, homogenization pressure be 60 ~
120Mpa, homogenizing time is 10 ~ 20min, is cooled to room temperature, produces nanoemulsions.
7. according to claim 5 have hair tonic, scalp maintenance, the composition of moisture-keeping efficacy, it is characterised in that the Chinese juniper
The preparation method of building extract comprises the following steps：Take fresh snakegourd complete stool dry, pulverize, cross 10 ~ 15 mesh sieves, add raw material
The ethanol that 8 ~ 10 times of amount volume fractions of weight are 70%, adds the cellulase of raw material total amount 0.8 ~ 1.2%, in 38 ~ 45 DEG C of bars
1 ~ 2h is extracted under part, then in 80 ~ 90 DEG C of condition 2 ~ 3h of refluxing extraction, filtrate is carried out vacuum-concentrcted drying, i.e., by filtering
Snakegourd extract is obtained, it is 5000U/g that the ratio of its cellulase, which is lived,；
The preparation method of the polygala root extract comprises the following steps：Take fresh payta dry, pulverize, cross 10 ~ 15 mesh
Sieve, coarse powder is placed in supercritical carbon dioxide extraction apparatus, adds the second that the volume fraction of coarse powder total amount 30 ~ 45% is 60 ~ 85%
Alcohol, regulation and control carbon dioxide flow is 15 ~ 20L/h, and extracting pressure is 15 ~ 20MPa, and extraction temperature is 40 ~ 60 DEG C, and extraction time is
Polygala root extract is made in 1.5 ~ 2h, decompression separation；
The preparation method of the camellia flower extract comprises the following steps：Take fresh camellia dry, pulverize, cross 10 ~ 15 mesh
Sieve, adds the ethanol that 8 ~ 10 times of raw material weight amount volume fractions are 70%, continuous under the conditions of 60 ~ 70 DEG C to extract 2 ~ 3 times, and every time 3
~ 4h, filtering, merging filtrate；The CMS adsorbent of filtrate weight 5% is added into filtrate, is stirred, room temperature condition
Lower standing 12h, is filtered to remove contamination precipitation；The filtered fluid after contamination precipitation will be removed and carry out vacuum-concentrcted drying, produced
Camellia flower extract.
8. it is a kind of prepare as described in claim 1-7 is any there is hair tonic, the method for the composition of scalp maintenance effect, it is special
Levy and be, comprise the following steps：
（1）Take thickener and water to mix, be warming up to 85 DEG C, stir, after material is completely dissolved, be incubated 30min；
（2）50 DEG C are cooled to, snakegourd extract, polygala root extract, camellia flower extract, nanoemulsions and moisturizing is sequentially added
Agent, 1500 ~ 2000r/min homogeneous, 6 ~ 12min；
（3）Continue to be cooled to 40 DEG C, sequentially add five ore deposit peptides, GP4G, Prolixir ICE and preservative, fully stir
Mix uniform, produce.
9. according to claim 8 have hair tonic, scalp maintenance, the preparation method of the composition of moisture-keeping efficacy, its feature
It is, the preparation method of the nanoemulsions comprises the following steps：
（1）Rice chaff oil, caprylic/capric triglyceride, phosphatide, Phenoxyethanol and the smooth oleate of sorb are mixed, 70 DEG C are heated to,
Heat while stirring, until material is completely dissolved, it is standby；
（2）Toward step（1）Water is added in material after dissolving, under conditions of rotating speed is 500r/min, 3 ~ 5min is stirred, prepares
Thick emulsion；
（3）Treat that thick emulsion is cooled to 40 DEG C, by thick emulsion be added to high pressure homogenizer carry out homogeneous, homogenization pressure be 60 ~
120Mpa, homogenizing time is 10 ~ 20min, is cooled to room temperature, produces nanoemulsions；
The preparation method of the snakegourd extract comprises the following steps：Take fresh snakegourd complete stool dry, pulverize, cross 10 ~ 15 mesh
Sieve, adds the ethanol that 8 ~ 10 times of amount volume fractions of raw material weight are 70%, adds the cellulase of raw material total amount 0.8 ~ 1.2%,
1 ~ 2h is extracted under the conditions of 38 ~ 45 DEG C, then in 80 ~ 90 DEG C of condition 2 ~ 3h of refluxing extraction, filtrate is carried out vacuum decompression by filtering
It is concentrated and dried, produces snakegourd extract, it is 5000U/g that the ratio of its cellulase, which is lived,；
The preparation method of the polygala root extract comprises the following steps：Take fresh payta dry, pulverize, cross 10 ~ 15 mesh
Sieve, coarse powder is placed in supercritical carbon dioxide extraction apparatus, adds the second that the volume fraction of coarse powder total amount 30 ~ 45% is 60 ~ 85%
Alcohol, regulation and control carbon dioxide flow is 15 ~ 20L/h, and extracting pressure is 15 ~ 20MPa, and extraction temperature is 40 ~ 60 DEG C, and extraction time is
Polygala root extract is made in 1.5 ~ 2h, decompression separation；
The preparation method of the camellia flower extract comprises the following steps：Take fresh camellia dry, pulverize, cross 10 ~ 15 mesh
Sieve, adds the ethanol that 8 ~ 10 times of raw material weight amount volume fractions are 70%, continuous under the conditions of 60 ~ 70 DEG C to extract 2 ~ 3 times, and every time 3
~ 4h, filtering, merging filtrate；The CMS adsorbent of filtrate weight 5% is added into filtrate, is stirred, room temperature condition
Lower standing 12h, is filtered to remove contamination precipitation；The filtered fluid after contamination precipitation will be removed and carry out vacuum-concentrcted drying, produced
Camellia flower extract.
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| CN108272700A (en) * | 2018-04-18 | 2018-07-13 | 滕建芬 | A kind of composition and preparation method thereof with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies |
| CN109528541A (en) * | 2018-12-18 | 2019-03-29 | 澳宝化妆品（惠州）有限公司 | A kind of cleaning compositions of the polynary yeast complexing polypeptide containing five mines |
| CN109846743B (en) * | 2019-04-03 | 2020-02-21 | 泉后(深圳)投资发展有限公司 | Moisturizing and repairing composition and preparation method and application thereof |
| CN115105461A (en) * | 2022-08-08 | 2022-09-27 | 广州发妍化妆品制造有限公司 | Nourishing composition for hair conditioner and hair conditioner containing same |
| CN115282098B (en) * | 2022-08-26 | 2023-03-21 | 珠海市丝域生物科技有限公司 | Composition with antibacterial and anti-dandruff effects and preparation method and application thereof |
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