CN106265164A - There is compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy and preparation method thereof - Google Patents
There is compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of compositions with hair growth promoting, scalp maintenance, moisture-keeping efficacy and preparation method thereof.Described compositions is made up of the raw material of following percentage by weight meter: Fructus Trichosanthis extract 0.5～20%, payta extract 0.5～12%, Flos Camelliae Japonicae extract 0.5～10%, five ore deposit peptides 0.2～2%, GP4G 0.2～2%, Prolixir ICE 1～2%, nanoemulsions 1～10%, wetting agent 1～5%, thickening agent 0.1～2%, preservative 0.01～1.0%, surplus is deionized water.Wherein, nanoemulsions is prepared from the following materials: rice chaff oil, octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester, phospholipid, the smooth oleate of Pyrusussuriensis, phenoxyethanol and water.Compositions character of the present invention is gentle, non-stimulated, can effectively moisten, maintenance hair, has preferable hair growth promoting, scalp maintenance, moisture-keeping efficacy, and preparation method simple, and cost is relatively low.
Description
Technical field
The present invention relates to daily cosmetics field, be specifically related to a kind of there is hair growth promoting, scalp maintenance, the combination of moisture-keeping efficacy
Thing and preparation method thereof.
Background technology
The fast pace of modern's life, work pressure with nervous, have hair dyed and the hair caring molded product such as hair-waving abuse with
And the factors such as diet and communication, make depilation phenomenon more and more universal, present rejuvenation trend, not only affect beauty treatment, return
The spirit of people, psychology produce large effect.Therefore, the research and development of anti-hair loss products more and more by the world medicine with
The attention of cosmetics circle.
Alopecia is common trichopathy, including alopecia areata, seborrheic alopecia, androgenetic alopecia, psychogenic alopecia, old age
Property alopecia and alopecia due to chemotherapy etc., the especially sickness rate with alopecia areata and seborrheic alopecia is the highest, is owing to some factor causes hair
Send out the resting stage being entered hair growth by trophophase too early, hair follicle and ball top atrophy, terminal hair become thin hair and draw
Rise.Research shows, alopecia except having with heredity outside the Pass, also with androgen levels, antibacterial and fungal infection, endocrine regulation, nutrition
Bad, blood vessel microcirculation disturbance, psychentonia, stress are relevant with factors such as drug side effectes.
The daily cosmetics about phalacrosis prevention and hair generation the most on the market is a feast for the eyes, and most products all with the addition of more
Chemical substance, rapid-action, effect substantially, but easily causes more side effect, such as anaphylaxis etc..Therefore, natural activity
Hair growth promoting composition is the feature of current research, and along with active ingredient of natural plant extraction and separation technology becomes better and approaching perfection day by day, various functions
Property active skull cap components is determined and applies to phalacrosis prevention and hair generation field, such as: Herba Centellae, Radix Ginseng, Radix Angelicae Sinensis, the Radix Polygoni Multiflori, Semen Ginkgo, rat-tail
The natural plant extracts such as grass and seaweeds.But these natural component function singlenesses, to anti-alopecia-stopping, promote the effect of hair growth promoting not
Significantly, and there is effective ingredient and preserve the shortcoming unstable, extraction efficiency is the highest.
Chinese patent application 201310379802.3 discloses the hair-loss preventing and hair-restoring hair washing of herbal essences and biochemical component formula
Dew and preparation method thereof.The modern herbal essences of this hair-loss preventing and hair-restoring shampoo selection: artemia extract, hydrolysed rice albumen, hydrolysis
Zein, Semen Pisi sativi extract, extractive of flax seed, Pericarpium Granati extract, propolis extract, black extract of willow bark, Radix Betae
Root extract, Folium Menthae extract, and modern biochemical component: people's oligopeptide-11, people's oligopeptide-3, people's oligopeptide-10, copper tripeptides-2, fourth
Herba Pelargonii Graveolentis stem cell liquid, oat polypeptide, cooperation natural source surfactant: lauryl glucoside, decyl glucoside, cocos nucifera oil acyl paddy ammonia
Acid sodium, LAA, soapbark extract are prepared from, and are that a kind of hair-loss preventing and hair-restoring natural, safe and effective is washed
Become visible, but this shampoo formula component is more, relatively costly.
Summary of the invention
It is an object of the invention to provide and a kind of there is hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy, described combination
Physical property matter is gentle, non-stimulated, can effectively moisten, maintenance hair, has preferable hair growth promoting, scalp maintenance, moisture-keeping efficacy, and system
Preparation Method is simple, and cost is relatively low.
The present invention is by following technical solution to be attained in that
A kind of have hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy are made up of the raw material of following percentage by weight meter: Chinese juniper
Building extract 0.5～20%, payta extract 0.5～12%, Flos Camelliae Japonicae extract 0.5～8%, five ore deposit peptides 0.2～2%,
GP4G 0.2～2%, Prolixir ICE 1～2%, nanoemulsions 1～10%, wetting agent 1～5%, thickening agent
0.1～2%, preservative 0.01～1.0%, surplus is deionized water.
Preferably, described compositions is made up of the raw material of following percentage by weight meter: Fructus Trichosanthis extract 12%, payta
Extract 8%, Flos Camelliae Japonicae extract 6%, five ore deposit peptide 1.0%, GP4G 1.5%, Prolixir ICE 2%, nanometer
Emulsion 6%, wetting agent 3%, thickening agent 0.5%, preservative 0.2%, surplus is deionized water.
Further, described nanoemulsions is prepared from by the raw material of following percentage by weight meter: rice chaff oil 5～
10%, octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester 1～5%, phosphatidase 1～8%, the smooth oleate of Pyrusussuriensis 1～8%, phenoxyethanol 0.1～1% and
Water 68～80%.
Preferably, described nanoemulsions is prepared from by the raw material of following percentage by weight meter: rice chaff oil 8%, octanoic acid
Triglyceride 3%, phosphatidase 5 %, the smooth oleate of Pyrusussuriensis 5%, phenoxyethanol 0.2% and water 78.8%.
Further, described wetting agent is polyalcohols, polysaccharide, natural silk peptide, NMF-50, squalane and pyrrolidine
At least one in keto carboxylic acid sodium；
Described thickening agent be HANSHENGJIAO, guar gum, carrageenan, gellan gum, cellulose, at least the one of card ripple apoplexy due to endogenous wind
Kind；
Described preservative is dimethyl isothiazolone, imidazolidinyl urea, dimethyloldimethylhydantoin, benzene oxygen
At least one in ethanol, iodine propilolic alcohol butyl mephenesin Carbamate, DMDM Hydantoin.
Additionally, the present invention also provides for the preparation method of a kind of described compositions, comprise the following steps:
(1) take thickening agent and water mixing, be warming up to 85 DEG C, stir, after material is completely dissolved, be incubated 30min；
(2) be cooled to 50 DEG C, be sequentially added into Fructus Trichosanthis extract, payta extract, Flos Camelliae Japonicae extract, nanoemulsions and
Wetting agent, 1500～2000r/min homogenizing 6～12min；
(3) continue to be cooled to 40 DEG C, be sequentially added into five ore deposit peptides, GP4G, Prolixir ICE and preservative, fill
Divide and stir, to obtain final product.
Wherein, the preparation method of described nanoemulsions comprises the following steps:
(1) rice chaff oil, octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester, phospholipid, phenoxyethanol and the smooth oleate of Pyrusussuriensis are mixed, be heated to
70 DEG C, heat while stirring, until material is completely dissolved, standby；
(2) toward step (1) dissolve after material in add water, under conditions of rotating speed is 500r/min, stirring 3～
5min, prepares thick emulsion；
(3) treat that thick emulsion is cooled to 40 DEG C, thick emulsion joined high pressure homogenizer and carries out homogenizing, homogenization pressure be 60～
120Mpa, homogenizing time is 10～20min, is cooled to room temperature, obtains nanoemulsions.
Wherein, the preparation method of described Fructus Trichosanthis extract comprises the following steps: takes fresh Fructus Trichosanthis Herb and dry, pulverize,
Crossing 10～15 mesh sieves, adding raw material weight 8～10 times amount volume fraction is the ethanol of 70%, add raw material total amount 0.8～
The cellulase of 1.2%, extracts 1～2h, then in 80～90 DEG C of condition reflux, extract, 2～3h, mistake under the conditions of 38～45 DEG C
Filter, carries out vacuum-concentrcted by filtrate and is dried, obtain Fructus Trichosanthis extract, and the ratio of its cellulase is lived as 5000U/g.
Wherein, the preparation method of described payta extract comprises the following steps: takes fresh payta and dry, pulverize,
Cross 10～15 mesh sieves, coarse powder is placed in supercritical carbon dioxide extraction apparatus, add coarse powder total amount 30～45% volume fraction
Being the ethanol of 60～85%, regulation and control carbon dioxide flow is 15～20L/h, and extracting pressure is 15～20MPa, and extraction temperature is 40
～60 DEG C, extraction time is 1.5～2h, and decompression separation prepares payta extract.
Wherein, the preparation method of described Flos Camelliae Japonicae extract comprises the following steps: takes fresh Flos Camelliae Japonicae and dry, pulverize,
Crossing 10～15 mesh sieves, adding raw material weight 8～10 times amount volume fraction is the ethanol of 70%, carries continuously under the conditions of 60～70 DEG C
Take 2～3 times, each 3～4h, filter, merging filtrate；In filtrate, add the carboxymethyl starch adsorbent of filtrate weight 5%, stir
Mix uniformly, stand 12h under room temperature condition, be filtered to remove contamination precipitation；Filtrate after removing contamination precipitation carries out vacuum and subtracts
Pressure concentrate drying, obtains Flos Camelliae Japonicae extract.
Of the present invention have hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy can directly use, can also conduct
Main component is used for preparing the products such as shampoo class, hair conditioner (newborn) class, hair-care essence liquid class.
Of the present invention have hair growth promoting, scalp maintenance, moisture-keeping efficacy compositions with Fructus Trichosanthis extract, payta extract
Thing and Flos Camelliae Japonicae extract are as main active.Wherein, Fructus Trichosanthis extract is rich in triterpene saponin, alkaloid, flavone, polysaccharide
Deng effective ingredient, there is significant bacteriostasis, antibacterial and fungus are all had preferable inhibition, and expansible blood vessel, changes
Kind microcirculation, increases blood flow.Described payta extract rich in saponins, mouth diphenylene ketone oxide and oligosaccharide ester, have intelligent promoting and the mind tranquilizing,
Tranquilizing soporific, antibacterial anti-inflammatory, antioxidation, the effect of defying age.Described Flos Camelliae Japonicae extract is rich in tea polyphenols, total saponins, total
Flavone and vitamin B1, B2, have significant antioxidation, anti-inflammation, the effect of regulating blood flow amount, rich in tea polyphenols to 5-
Alpha-reductase has a significant inhibitory action, scalable hormonal readiness, the secretion of suppression sebaceous gland, rich in vitamin B1 and B2
It is the coenzyme of cell biooxidation and energy metabolism, can promote to grow and cell regeneration.Of the present invention have hair growth promoting, scalp
Maintenance, compositions comprehensive utilization Fructus Trichosanthis extract, payta extract and effect of Flos Camelliae Japonicae extract of moisture-keeping efficacy, from changing
Kind microcirculation, anti-inflammation, suppresses 5-alpha-reductase, promotes that multiple angles such as cell regeneration are set out, give full play to hair growth promoting, scalp
Maintenance, effect of moisturizing.
Additionally, of the present invention there is hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy are aided with interpolation five ore deposit peptides, four
Di(2-ethylhexyl)phosphate guanosine, Prolixir ICE, from recovering nutrition mechanism, compose Rhizoma Imperatae of living, and the angle of trophonema blast cell and hair is set out,
Moisten scalp, promote regeneration and the growth of hair.Wherein, five described ore deposit peptides are active mineral yeast polypeptides, are i.e. mineral units
The complex that element is formed with yeast polypeptides, the specially zinc of yeast polypeptides complexation, copper, magnesium, ferrum and silicon, purchased from U.S.'s Chinese mugwort orange red science and technology
Company (Active Concepts), it, with the existence form closest to human body mineral element, supplements micro-directly to skin (hair)
Amount mineral element, is quickly absorbed, can be smoothed hair hair scale sheet, it is possible to the hair chemically and physically damaged of releiving.
Described GP4G (GP4G), is a kind of cellular energy extracted from halomereid element, is purchased from
International Specialty Products company of the U.S. (ISP), can supplement energy to cell rapidly, activate the various physiological activities of Skin Cell and new old generation
Thank, and there is DNA protection and the function repaired.
Described Prolixir ICE is that proteasome is lived the factor only, is derived from hydrolysed rice albumen, purchased from Ya Shilan China
(ASHLAND), by maintaining proteasome effect, reduce Protein Damage, improve the various enzymatic activitys relevant with hair growth
Abnormal, promote hair growth.
Of the present invention have hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy are aided with interpolation nanoemulsions, described
Nanoemulsions is the nanometer colloid of a kind of monolayer membrane structure being made up of with certain proportion lecithin and cosurfactant,
Can system transparent with water, breast etc. miscible, form closed effect at skin surface, increase skin moisture-keeping performance, and receiving with unique
Rice biological effect, is effectively improved the stability of active component in compositions, and promotes that active component diffusion is through skin keratin
Layer, is absorbed by epidermis cell or fused, gives full play to effect of active component.
Compared with prior art, the invention have the benefit that
(1) of the present invention have hair growth promoting, scalp maintenance, moisture-keeping efficacy each component of compositions mutually coordinated, mutually
Gain, from improving microcirculation, anti-inflammation, suppresses 5-alpha-reductase, promotes that multiple angles such as cell regeneration are set out, give full play to
Hair growth promoting, scalp maintenance, effect of moisturizing, and from recovering nutrition mechanism, compose Rhizoma Imperatae of living, the angle of trophonema blast cell and hair goes out
Send out, moisten scalp, promote regeneration and the growth of hair.
(2) present invention is by adding appropriate nanoemulsions, utilizes the nanobiology effect that nanoemulsions is unique, effectively
Improve the stability of active component in compositions, and promote that active component penetrates in scalp cells, to give full play to activity one-tenth
The effect divided.
(3) the compositions character gentleness with hair growth promoting, scalp maintenance, moisture-keeping efficacy of the present invention, without any bad
Stimulating and side effect, using effect is notable, safe and reliable, and preparation method is simple, and cost is relatively low.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following example.
The preparation of embodiment 1 nanoemulsions
The formula of A-E group nanoemulsions see table:
| Component | A group | B group | C group | D group | E group |
| Rice chaff oil (%) | 5 | 10 | 8 | 6 | 10 |
| Trivent OCG (%) | 5 | / | 3 | / | 5 |
| Certain herbaceous plants with big flowers acid glycerol three ester (%) | / | 1 | / | 5 | / |
| Phospholipid (%) | 8 | 1 | 5 | 6 | 8 |
| The smooth oleate of Pyrusussuriensis (%) | 1 | 8 | 5 | 4 | 8 |
| Phenoxyethanol (%) | 1 | 0.1 | 0.2 | 0.5 | 1 |
| Water (%) | 80 | 79.9 | 78.8 | 78.5 | 68 |
Preparation method:
(1) rice chaff oil, octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester, phospholipid, phenoxyethanol and the smooth oleate of Pyrusussuriensis are mixed, be heated to
70 DEG C, heat while stirring, until material is completely dissolved, standby；
(2) material after dissolving toward step (1) adds water, under conditions of rotating speed is 500r/min, stirs 4min, system
Standby thick emulsion；
(3) treating that thick emulsion is cooled to 40 DEG C, thick emulsion is joined high pressure homogenizer and carries out homogenizing, homogenization pressure is
80Mpa, homogenizing time is 15min, is cooled to room temperature, obtains nanoemulsions.
Embodiment 2 nanoemulsions quality testing
Use laser particle analyzer (Britain, Malvern instrument) nanometer ZS90 by dynamic light scattering to receiving that A-E group prepares
Rice emulsion mean diameter and particle size distribution are measured.The sample cell that fixed angle is 173 DEG C measures, the liquid of emulsion
Dripping size is the average diameter describing accumulation measured value.Polydispersity index (the Polymer of particle size distribution particle diameter
Dispersity index, PDI) describe.The results are shown in Table 1.
The mean diameter of table 1 nanoemulsions and PDI
| Index | A group | B group | C group | D group | E group |
| Mean diameter (nm) | 25.84 | 23.16 | 20.15 | 27.40 | 29.56 |
| PDI | 0.13 | 0.12 | 0.11 | 0.14 | 0.15 |
PDI represents the particle diameter distribution of drop in system, and its value is the least, represents that particle size dispersion is the most single, as seen from the above table, and C
The mean diameter of nanoemulsions and PDI that group prepares are minimum, better quality, the most of the present invention have hair growth promoting, scalp is repaiied
Protect, the compositions of moisture-keeping efficacy is all prepared using the nanoemulsions that C group is prepared as raw material.
Embodiment 3 has the preparation of the compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
The embodiment of the present invention 3 has former by following percentage by weight meter of compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Material composition: Fructus Trichosanthis extract 12%, payta extract 8%, Flos Camelliae Japonicae extract 6%, five ore deposit peptide 1.0%, four di(2-ethylhexyl)phosphate bird
Glycosides 1.5%, Prolixir ICE 2%, nanoemulsions 6%, wetting agent 3%, thickening agent 0.5%, preservative 0.2%, surplus is
Deionized water.
Preparation method:
(1) preparation of Fructus Trichosanthis extract: take fresh Fructus Trichosanthis Herb and dry, pulverize, crosses 15 mesh sieves, adds raw material weight 10
Times amount volume fraction is the ethanol of 70%, adds the cellulase of raw material total amount 1.2%, extracts 2h, so under the conditions of 45 DEG C
After 90 DEG C of condition reflux, extract, 3h, filter, filtrate carried out vacuum-concentrcted and is dried, obtain Fructus Trichosanthis extract, wherein fine
The ratio of dimension element enzyme is lived as 5000U/g.
(2) preparation of payta extract: take fresh payta and dry, pulverize, crosses 15 mesh sieves, and coarse powder is placed in super facing
In boundary's carbon dioxide extraction apparatus, adding coarse powder total amount 45% volume fraction is the ethanol of 60%, and regulation and control carbon dioxide flow is
20L/h, extracting pressure is 20MPa, and extraction temperature is 40 DEG C, and extraction time is 2h, and decompression separation prepares payta extract.
(3) preparation of Flos Camelliae Japonicae extract: take fresh Flos Camelliae Japonicae floral leaf and dry, pulverize, crosses 15 mesh sieves, adds raw material weight
10 times amount volume fractions are the ethanol of 70%, extract 3 times continuously, each 3h under the conditions of 70 DEG C, filter, merging filtrate；Toward filter
Liquid adds the adsorbent of filtrate weight 5%, stirs, stand 12h under room temperature condition, be filtered to remove contamination precipitation；To remove
Filtrate after decontamination precipitation carries out vacuum-concentrcted and is dried, and obtains Flos Camelliae Japonicae extract.
(4) preparation of anti-shed hair growth liquid:
1. take thickening agent and water mixing, be warming up to 85 DEG C, stir, after material is completely dissolved, be incubated 30min；
2. be cooled to 50 DEG C, be sequentially added into Fructus Trichosanthis extract, payta extract, Flos Camelliae Japonicae extract, nanoemulsions and
Wetting agent, 2000r/min homogenizing 6min；
3. continue to be cooled to 40 DEG C, be sequentially added into five ore deposit peptides, GP4G, Prolixir ICE and preservative, fill
Divide and stir, to obtain final product.
Embodiment 4 has the preparation of the compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
The embodiment of the present invention 4 has former by following percentage by weight meter of compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Material composition: Fructus Trichosanthis extract 20%, payta extract 0.5%, Flos Camelliae Japonicae extract 8%, five ore deposit peptide 2%, four di(2-ethylhexyl)phosphate bird
Glycosides 0.2%, Prolixir ICE 1%, nanoemulsions 10%, wetting agent 5%, thickening agent 2%, preservative 0.01%, surplus is
Deionized water.
Preparation method:
(1) preparation of Fructus Trichosanthis extract: take fresh Fructus Trichosanthis Herb and dry, pulverize, crosses 10 mesh sieves, adds raw material weight 8
Times amount volume fraction is the ethanol of 70%, adds the cellulase of raw material total amount 0.8%, extracts 1h, so under the conditions of 38 DEG C
After 80 DEG C of condition reflux, extract, 2h, filter, filtrate carried out vacuum-concentrcted and is dried, obtain Fructus Trichosanthis extract, wherein fine
The ratio of dimension element enzyme is lived as 5000U/g.
(2) preparation of payta extract: take fresh payta and dry, pulverize, crosses 10 mesh sieves, and coarse powder is placed in super facing
In boundary's carbon dioxide extraction apparatus, adding coarse powder total amount 30% volume fraction is the ethanol of 85%, and regulation and control carbon dioxide flow is
15L/h, extracting pressure is 15MPa, and extraction temperature is 60 DEG C, and extraction time is 1.5h, and decompression separation prepares payta and extracts
Thing.
(3) preparation of Flos Camelliae Japonicae extract: take fresh Flos Camelliae Japonicae floral leaf and dry, pulverize, crosses 10 mesh sieves, adds raw material weight
8 times amount volume fractions are the ethanol of 70%, extract 2 times continuously, each 4h under the conditions of 60 DEG C, filter, merging filtrate；Toward filtrate
The middle adsorbent adding filtrate weight 5%, stirs, and stands 12h, be filtered to remove contamination precipitation under room temperature condition；To remove
Filtrate after contamination precipitation carries out vacuum-concentrcted and is dried, and obtains Flos Camelliae Japonicae extract.
(4) preparation of anti-shed hair growth liquid:
1. take thickening agent and water mixing, be warming up to 85 DEG C, stir, after material is completely dissolved, be incubated 30min；
2. be cooled to 50 DEG C, be sequentially added into Fructus Trichosanthis extract, payta extract, Flos Camelliae Japonicae extract, nanoemulsions and
Wetting agent, 1500r/min homogenizing 12min；
3. continue to be cooled to 40 DEG C, be sequentially added into five ore deposit peptides, GP4G, Prolixir ICE and preservative, fill
Divide and stir, to obtain final product.
Embodiment 5 has the preparation of the compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
The embodiment of the present invention 5 has former by following percentage by weight meter of compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Material composition: Fructus Trichosanthis extract 8%, payta extract 12%, Flos Camelliae Japonicae extract 0.5%, five ore deposit peptide 0.6%, four di(2-ethylhexyl)phosphate
Guanosine 2%, Prolixir ICE 1.5%, nanoemulsions 4%, wetting agent 2%, thickening agent 1%, preservative 1%, surplus is for going
Ionized water.
Preparation method reference example 3.
Embodiment 6 has the preparation of the compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
The embodiment of the present invention 6 has former by following percentage by weight meter of compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Material composition: Fructus Trichosanthis extract 0.5%, payta extract 6%, Flos Camelliae Japonicae extract 2%, five ore deposit peptide 0.2%, four di(2-ethylhexyl)phosphate bird
Glycosides 1%, Prolixir ICE 1%, nanoemulsions 1%, wetting agent 1%, thickening agent 0.1%, preservative 0.5%, surplus is for going
Ionized water.
Preparation method reference example 3.
Comparative example 1 has the preparation of the compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Comparative example 1 of the present invention has former by following percentage by weight meter of compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Material composition: Fructus Trichosanthis extract 12%, payta extract 8%, Flos Camelliae Japonicae extract 6%, five ore deposit peptide 1.0%, four di(2-ethylhexyl)phosphate bird
Glycosides 1.5%, Prolixir ICE 2%, wetting agent 3%, thickening agent 0.5%, preservative 0.2%, surplus is deionized water.
Preparation method reference example 3, this comparative example is without nanoemulsions with the difference of embodiment 3.
Comparative example 2 has the preparation of the compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Comparative example 2 of the present invention has former by following percentage by weight meter of compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Material composition: payta extract 12%, Flos Camelliae Japonicae extract 8%, five ore deposit peptide 1.0%, GP4G 1.5%,
Prolixir ICE2%, nanoemulsions 6%, wetting agent 3%, thickening agent 0.5%, preservative 0.2%, surplus is deionized water.
Preparation method reference example 3, this comparative example is without Fructus Trichosanthis extract with the difference of embodiment 3, and phase
Payta extract and the ratio of Flos Camelliae Japonicae extract should be increased.
Comparative example 3 has the preparation of the compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Comparative example 3 of the present invention has former by following percentage by weight meter of compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Material composition: Fructus Trichosanthis extract 12%, payta extract 8%, Flos Camelliae Japonicae extract 6%, five ore deposit peptide 1.0%, Prolixir
ICE 2%, nanoemulsions 6%, wetting agent 3%, thickening agent 0.5%, preservative 0.2%, surplus is deionized water.
Preparation method reference example 3, this comparative example is without GP4G with the difference of embodiment 3.
Comparative example 4 has the preparation of the compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Comparative example 4 of the present invention has former by following percentage by weight meter of compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
Material composition: Fructus Trichosanthis extract 12%, payta extract 8%, Flos Camelliae Japonicae extract 6%, five ore deposit peptide 1.0%, four di(2-ethylhexyl)phosphate bird
Glycosides 1.5%, nanoemulsions 6%, wetting agent 3%, thickening agent 0.5%, preservative 0.2%, surplus is deionized water.
Preparation method reference example 3, this comparative example is without Prolixir ICE with the difference of embodiment 3.
Test example one, irritation test
Screening 100 volunteers, age 20～50 years old, men and women half and half, and all volunteers, all without dermatopathy, test position
Skin the most normal.According to human body skin patch in Ministry of Health of the People's Republic of China's " cosmetics health specification (2002 editions) "
The basic principle of test and method, have hair growth promoting, scalp maintenance, moisturizing to what embodiment of the present invention 3-6 and comparative example 1-4 prepared
The compositions of effect carries out the note test of human body skin class, particularly as follows: compositions is diluted to 1% aqueous solution, as given the test agent；
Take 0.025ml sample drop with syringe to be added on filter paper appended by speckle examination device, be placed in speckle examination device.Speckle is tried device and is affixed on experimenter
Back, the lightest pressing room is to drive away air, and makes trier be uniformly distributed, and removes given the test agent, after 30min after 24h
Observed result, 24h, 48h repeated observation, and make blank.
Wherein irritation test standard of perfection is: 0 grade: non-stimulated, without erythema；1 grade: slight erythema；2 grades: erythema；
3 grades: erythema, pimple, vesicle；4 grades: serious edema, bulla, the results are shown in Table 1.
Table 1 present invention has the Skin Irritation Test result of the compositions of hair growth promoting, scalp maintenance, moisture-keeping efficacy
| Group | Phenomenon |
| Blank | Non-stimulated, without erythema |
| Embodiment 3 | Non-stimulated, without erythema |
| Embodiment 4 | Non-stimulated, without erythema |
| Embodiment 5 | Non-stimulated, without erythema |
| Embodiment 6 | Non-stimulated, without erythema |
| Comparative example 1 | Non-stimulated, without erythema |
| Comparative example 2 | Non-stimulated, without erythema |
| Comparative example 3 | Non-stimulated, without erythema |
| Comparative example 4 | Non-stimulated, without erythema |
Result shows, the present invention provide have hair growth promoting, scalp maintenance, moisture-keeping efficacy compositions non-stimulated to skin,
Will not cause erythema, safety is high.
Test example two, phalacrosis prevention and hair generation effect assessment are tested
The seborrheic alopecia volunteer patients of screening clinical definite and each 450 examples of alopecia areata volunteer patients, age 25～55 years old, its
In, male's seborrheic alopecia volunteer patients 360 example, women seborrheic alopecia volunteer patients 90 example；Male alopecia areata volunteer patients 315
Example, women alopecia areata volunteer patients 135 example.Respectively seborrheic alopecia volunteer patients and alopecia areata volunteer patients are randomly divided into comparison
Group, embodiment 3-6 group and comparative example 1-4 group, often group 50.Wherein, matched group gives commercially available overlord's hair nourishing liquid, takes about every time
5mL, uniform application is in volunteer patients's alopecia position, and suitably massages to promote to absorb, 1～2 times/day；Embodiment 3-6 group and right
What ratio 1-4 group gave that volunteer patients uses that embodiment of the present invention 3-6 and comparative example 1-4 provide respectively have hair growth promoting, scalp is repaiied
Protect, the compositions of moisture-keeping efficacy, 1～2 times/day, the most about 2mL, compositions is coated in and needs the position of hair growth promoting, then massage
5min, then wash off with clear water, it was 1 course for the treatment of with 2 months, persistently uses 2 courses for the treatment of, observe curative effect.
The standard of curative effect evaluation is: 1) recovery from illness: hair stops coming off, newly sending out and all grow, its distribution density, thickness, color and luster
Identical with Jian Fa district, sebum secretion recovers normal.2) effective: hair stops coming off, a new regeneration reaches more than 70%, and its distribution is close
Degree, thickness, color and luster significantly reduce close to Jian Fa district, sebum secretion.3) effective: hair stops coming off, new send out regeneration reach 30% with
On, grow including fine hair on birds or animals hair and poliosis.4) invalid: new sending out regenerates less than 30% or continue to de-originator.The results are shown in Table 2 and 3.
Table 2 present composition phalacrosis prevention and hair generation effect to seborrheic alopecia volunteer patients
Table 3 present composition phalacrosis prevention and hair generation effect to alopecia areata volunteer patients
| Group | Cure | Effective | Effectively | Invalid | Effective percentage (%) |
| Matched group | 15 | 21 | 7 | 7 | 86 |
| Embodiment 3 | 17 | 21 | 7 | 5 | 90 |
| Embodiment 4 | 15 | 23 | 6 | 6 | 88 |
| Embodiment 5 | 13 | 21 | 8 | 8 | 84 |
| Embodiment 6 | 11 | 19 | 10 | 10 | 80 |
| Comparative example 1 | 7 | 10 | 13 | 20 | 60 |
| Comparative example 2 | 9 | 15 | 12 | 14 | 72 |
| Comparative example 3 | 11 | 18 | 9 | 12 | 76 |
| Comparative example 4 | 12 | 16 | 10 | 12 | 76 |
Result shows, seborrheic alopecia volunteer patients and alopecia areata are volunteered to suffer from by the compositions that embodiment of the present invention 3-6 prepares
Person is respectively provided with preferable phalacrosis prevention and hair generation effect, and effective percentage all reaches more than 80%, and wherein, the compositions that embodiment 3 and 4 prepares is to fat
The phalacrosis prevention and hair generation effect of excessive property alopecia volunteer patients and alopecia areata volunteer patients is superior to commercially available overlord's hair nourishing liquid.And comparative example 1-4
The effect of the compositions phalacrosis prevention and hair generation prepared substantially weakens, and the compositions phalacrosis prevention and hair generation effect especially prepared with comparative example 1 is worst.
Test example three, scalp care efficacy assessments are tested
Screen 450 and there is dandruff, the trial volunteer of head pruritus problem, age 25～55 years old, wherein male 180, female
Property 270.Trial volunteer is randomly divided into matched group, embodiment 3-6 group and comparative example 1-4 group, often group 50.Matched group is given
Giving commercially available Paris L'Oreal hyaluronic acid anti-dandruff shampoo, take about 1mL every time, uniform application is in hair, and suitably massages to promote
Enter to absorb, then clean with clear water, 1 times/day；Embodiment 3-6 group and comparative example 1-4 group give embodiment of the present invention 3-6 respectively
The compositions provided with comparative example 1-4, external every day 1 time, the most about 1mL, by compositions uniform application in hair, and suitably presses
Rub to promote to absorb, then clean with clear water, use 15 continuously, evaluate dandruff and head pruritus improves situation, the results are shown in Table 4.
Table 4 present composition scalp care effect assessment result
Result shows, the compositions that embodiment of the present invention 3-6 prepares has preferable hair nursing effect, can substantially reduce
Dandruff and head pruritus, its effect is superior to commercially available Paris L'Oreal hyaluronic acid anti-dandruff shampoo, and dandruff and head pruritus will not be caused to increase
Add.And the effect of the compositions hair nursing that comparative example 1-4 prepares substantially weakens, the compositions head especially prepared with comparative example 1
Send out nursing efficacy worst.
Below it is only the preferred embodiment of the present invention, it is noted that it is right that above-mentioned preferred implementation is not construed as
The restriction of the present invention, protection scope of the present invention should be as the criterion with claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, it is also possible to make some improvements and modifications, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (10)
1. one kind has hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy, it is characterised in that described compositions is by following heavy
The raw material composition of amount percentages: Fructus Trichosanthis extract 0.5～20%, payta extract 0.5～12%, Flos Camelliae Japonicae extract
0.5～8%, five ore deposit peptide 0.2～2%, GP4G 0.2～2%, Prolixir ICE 1～2%, nanoemulsions 1～
10%, wetting agent 1～5%, thickening agent 0.1～2%, preservative 0.01～1.0%, surplus is deionized water.
The most according to claim 1 have hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy, it is characterised in that described
Compositions is made up of the raw material of following percentage by weight meter: Fructus Trichosanthis extract 12%, payta extract 8%, Flos Camelliae Japonicae extract
Thing 6%, five ore deposit peptide 1.0%, GP4G 1.5%, Prolixir ICE 2%, nanoemulsions 6%, wetting agent 3%, increasing
Thick dose 0.5%, preservative 0.2%, surplus is deionized water.
The most according to claim 1 and 2 have hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy, it is characterised in that institute
The nanoemulsions stated is prepared from by the raw material of following percentage by weight meter: rice chaff oil 5～10%, octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester 1
～5%, phosphatidase 1～8%, the smooth oleate of Pyrusussuriensis 1～8%, phenoxyethanol 0.1～1% and water 68～80%.
The most according to claim 3 have hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy, it is characterised in that described
Nanoemulsions is prepared from by the raw material of following percentage by weight meter: rice chaff oil 8%, Trivent OCG 3%, phosphatidase 5 %, mountain
The smooth oleate of pears 5%, phenoxyethanol 0.2% and water 78.8%.
The most according to claim 1 and 2 have hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy, it is characterised in that
Described wetting agent is in polyalcohols, polysaccharide, natural silk peptide, NMF-50, squalane and pyrrolidone sodium carboxylate
At least one；
Described thickening agent be HANSHENGJIAO, guar gum, carrageenan, gellan gum, cellulose, card ripple apoplexy due to endogenous wind at least one；
Described preservative is dimethyl isothiazolone, imidazolidinyl urea, dimethyloldimethylhydantoin, benzene oxygen second
At least one in alcohol, iodine propilolic alcohol butyl mephenesin Carbamate, DMDM Hydantoin.
The most according to claim 1 have hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy, it is characterised in that described group
The preparation method of compound comprises the following steps:
(1) take thickening agent and water mixing, be warming up to 85 DEG C, stir, after material is completely dissolved, be incubated 30min；
(2) it is cooled to 50 DEG C, is sequentially added into Fructus Trichosanthis extract, payta extract, Flos Camelliae Japonicae extract, nanoemulsions and moisturizing
Agent, 1500～2000r/min homogenizing 6～12min；
(3) continue to be cooled to 40 DEG C, be sequentially added into five ore deposit peptides, GP4G, Prolixir ICE and preservative, fully stir
Mix uniformly, to obtain final product.
The most according to claim 6 have hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy, it is characterised in that described in receive
The preparation method of rice emulsion comprises the following steps:
(1) rice chaff oil, octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester, phospholipid, phenoxyethanol and the smooth oleate of Pyrusussuriensis are mixed, are heated to 70 DEG C,
Heat while stirring, until material is completely dissolved, standby；
(2) material after dissolving toward step (1) adds water, under conditions of rotating speed is 500r/min, stirs 3～5min, system
Standby thick emulsion；
(3) treat that thick emulsion is cooled to 40 DEG C, thick emulsion joined high pressure homogenizer and carries out homogenizing, homogenization pressure be 60～
120Mpa, homogenizing time is 10～20min, is cooled to room temperature, obtains nanoemulsions.
The most according to claim 6 have hair growth promoting, scalp maintenance, the compositions of moisture-keeping efficacy, it is characterised in that described Chinese juniper
The preparation method of building extract comprises the following steps: takes fresh Fructus Trichosanthis Herb and dry, pulverize, and crosses 10～15 mesh sieves, adds former
Material weight 8～10 times amount volume fraction is the ethanol of 70%, adds raw material total amount 0.8～the cellulase of 1.2%, 38～
Extract 1～2h under the conditions of 45 DEG C, then in 80～90 DEG C of condition reflux, extract, 2～3h, filter, filtrate is carried out vacuum decompression dense
Contracting is dried, and obtains Fructus Trichosanthis extract, and the ratio of its cellulase is lived as 5000U/g；
The preparation method of described payta extract comprises the following steps: takes fresh payta and dry, pulverize, and crosses 10～15 mesh
Sieve, is placed in coarse powder in supercritical carbon dioxide extraction apparatus, adds coarse powder total amount 30～45% volume fraction is 60～85%
Ethanol, regulation and control carbon dioxide flow be 15～20L/h, extracting pressure is 15～20MPa, and extraction temperature is 40～60 DEG C, extraction
The time of taking is 1.5～2h, and decompression separation prepares payta extract；
The preparation method of described Flos Camelliae Japonicae extract comprises the following steps: takes fresh Flos Camelliae Japonicae and dry, pulverize, and crosses 10～15 mesh
Sieve, adding raw material weight 8～10 times amount volume fraction is the ethanol of 70%, extracts 2～3 times continuously under the conditions of 60～70 DEG C,
Each 3～4h, filter, merging filtrate；In filtrate, add the carboxymethyl starch adsorbent of filtrate weight 5%, stir, room
Stand 12h under the conditions of temperature, be filtered to remove contamination precipitation；Filtrate after removing contamination precipitation carries out vacuum-concentrcted to be done
Dry, obtain Flos Camelliae Japonicae extract.
9. the method preparing the compositions with hair growth promoting, scalp maintenance effect as described in claim 1-8 is arbitrary, it is special
Levy and be, comprise the following steps:
(1) take thickening agent and water mixing, be warming up to 85 DEG C, stir, after material is completely dissolved, be incubated 30min；
(2) it is cooled to 50 DEG C, is sequentially added into Fructus Trichosanthis extract, payta extract, Flos Camelliae Japonicae extract, nanoemulsions and moisturizing
Agent, 1500～2000r/min homogenizing 6～12min；
(3) continue to be cooled to 40 DEG C, be sequentially added into five ore deposit peptides, GP4G, Prolixir ICE and preservative, fully stir
Mix uniformly, to obtain final product.
The preparation method of the compositions with hair growth promoting, scalp maintenance, moisture-keeping efficacy the most according to claim 9, its feature
Being, the preparation method of described nanoemulsions comprises the following steps:
(1) rice chaff oil, octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester, phospholipid, phenoxyethanol and the smooth oleate of Pyrusussuriensis are mixed, are heated to 70 DEG C,
Heat while stirring, until material is completely dissolved, standby；
(2) material after dissolving toward step (1) adds water, under conditions of rotating speed is 500r/min, stirs 3～5min, system
Standby thick emulsion；
(3) treat that thick emulsion is cooled to 40 DEG C, thick emulsion joined high pressure homogenizer and carries out homogenizing, homogenization pressure be 60～
120Mpa, homogenizing time is 10～20min, is cooled to room temperature, obtains nanoemulsions；
The preparation method of described Fructus Trichosanthis extract comprises the following steps: takes fresh Fructus Trichosanthis Herb and dry, pulverize, and crosses 10～15 mesh
Sieve, adding raw material weight 8～10 times amount volume fraction is the ethanol of 70%, adds raw material total amount 0.8～the cellulose of 1.2%
Enzyme, extracts 1～2h under the conditions of 38～45 DEG C, then in 80～90 DEG C of condition reflux, extract, 2～3h, filters, filtrate is carried out
Vacuum-concentrcted is dried, and obtains Fructus Trichosanthis extract, and the ratio of its cellulase is lived as 5000U/g；
The preparation method of described payta extract comprises the following steps: takes fresh payta and dry, pulverize, and crosses 10～15 mesh
Sieve, is placed in coarse powder in supercritical carbon dioxide extraction apparatus, adds coarse powder total amount 30～45% volume fraction is 60～85%
Ethanol, regulation and control carbon dioxide flow be 15～20L/h, extracting pressure is 15～20MPa, and extraction temperature is 40～60 DEG C, extraction
The time of taking is 1.5～2h, and decompression separation prepares payta extract；
The preparation method of described Flos Camelliae Japonicae extract comprises the following steps: takes fresh Flos Camelliae Japonicae and dry, pulverize, and crosses 10～15 mesh
Sieve, adding raw material weight 8～10 times amount volume fraction is the ethanol of 70%, extracts 2～3 times continuously under the conditions of 60～70 DEG C,
Each 3～4h, filter, merging filtrate；In filtrate, add the carboxymethyl starch adsorbent of filtrate weight 5%, stir, room
Stand 12h under the conditions of temperature, be filtered to remove contamination precipitation；Filtrate after removing contamination precipitation carries out vacuum-concentrcted to be done
Dry, obtain Flos Camelliae Japonicae extract.
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