CN109350589A - A kind of Chinese medicine hair nourishing hair growth liquor and preparation method thereof containing angelica extract - Google Patents
A kind of Chinese medicine hair nourishing hair growth liquor and preparation method thereof containing angelica extract Download PDFInfo
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Abstract
This application involves a kind of Chinese medicine hair nourishing hair growth liquor containing angelica extract, which is characterized in that the Chinese medicine hair nourishing hair growth liquor includes the following effective components extracted from Chinese medicine material: angelica extract；Shrubby sophora extract；Cacumen Platycladi extract；Salvia root P.E；Rhizoma Chuanxiong extract；Ginseng extract；Radix-polygoni multiflori extract；Rhizoma Gastrodiae extract；Mulberries extract；And solvent.The method that the application further relates to prepare the Chinese medicine hair nourishing hair growth liquor containing angelica extract.The inhibition of Radix Angelicae Sinensis " 5α-reductase " effect of the Chinese medicine hair nourishing hair growth liquor major embodiment of the application, and pass through the mutual synergistic effect of nine kinds of active Chinese drug component substances, scalp blood microcirculation can be improved, the activity of hair follicle cell is improved, have the effect of functions of nourishing hair and growing hair.In addition, Chinese medicine hair nourishing hair growth liquor of the invention can be used for treating the crowds such as male's alopecia seborrheica, alopecia areata, whole alopecia, and it is safe and non-stimulating, it prepares and easy to use；Hair can be good for by root by force, effectively reduce and shave one's head.
Description
Technical field
This application involves daily-use chemical industry and shield technical field is washed, it particularly relates to a kind of containing in angelica extract
Medicine functions of nourishing hair and growing hair liquid and preparation method thereof.
Background technique
Everyone about possesses 100,000-150,000 hair in all one's life, and every hair has different growth cycles, i.e.,
Growth period, catagen and stand-down.
The hair normally to fall off is at the hair of catagen and stand-down, grows due to entering catagen and newly entering
The hair of phase is constantly in dynamic equilibrium, therefore can maintain the hair of normal quantity.Pathologic alopecia refers to that hair is abnormal or excessive
Fall off, Symptoms are that hair is greasy, as polishing, also have it is shrivelled send out fluffy, lack gloss, have the faint yellow scales of skin that peel off solid
The difficult de- or canescence scales of skin that peel off fly upward, conscious itch.Male pattern baldness, mainly front and overhead, the hairline and temples of forehead
Toward moving up, the hair sparse at front and top, flavescence, softening make a piece of baldness or some fine hair at the top of volume eventually；Female alopecia exists
Overhead, hair become sparse, but not sheet of fall off completely.
There are many kinds of the reason of alopecia, and such as male sex hormone excessive secretion, the excessive secretion of seborrheica substance, scalp blood is followed
Ring obstacle, the scalp function as caused by the factors such as peroxidization, bacterium are lost, pressure, inherent cause etc.；Wherein, most
For generally alopecia seborrheica, 95% of patient or more is accounted for；Also, in modern society, alopecia crowd is biased to rejuvenation, and de-
Growth trend is presented in hair crowd's quantity.
The technology of hair growth currently on the market can all add some drugs, such as Western medicine to reach certain anticreep effect
Hormone is used to promote blood circulation as active constituent, strong root of hair function；5α-reductase inhibitor；Containing Western medicine minot
Your isoreactivity substance etc., but Western medicine has certain side effect to human body, long-term administration can cause certain body function disorder.
In hair follicle cell, testosterone is catalyzed by 5α-reductase, is converted into the stronger dihydrotestosterone of bioactivity (DHT), and two
Hydrogen testosterone and testosterone compete same receptor, but dihydrotestosterone activity is 5 times of testosterone.DHT combines androgen receptor in hair follicle
(AR), this special conjugate triggers the process of cell, disturbs the anagen in hair cycle period, hair mistake
The early vegetative rest phase for entering hair.Middle hair is gradually set to be converted into fine hair on birds or animals hair, hair follicle blank, and then hair covering is reduced, therefore
Inhibit 5α-reductase that there is positive effect to promotion natural on-off cycles of hair growth.General Western medicine uses Tamsulosin to inhibit as 5α-reductase
Agent, but have been reported that, side effect is to be easy to cause sexual dysfunction.
In addition, blood circulation is also extremely important for the growth of hair.In the anagen phase, the blood vessel of perifollicolar compares head
The blood vessel of hair stand-down will enrich, and for papilla in growth process, surrounding capilary will increase and formed network, to hair
Enough nutrition is provided.It has been reported that the decline of scalp flexibility decrease or subcutaneous tissue of scalp's peripheral vessel blood flow may be
The reason of causing natural on-off cycles of hair growth disorder.Clinically common depilation phenomenon is also uneven with the reduction of capillary quantity and nutrition
Weighing apparatus causes the reduction of hair follicle quantity to have direct relation.The clinically decompression performance of long minoxidil, reaches promotion hair growth
Effect；But minoxidil is used for a long time, certain dependence can be generated to drug, after drug withdrawal, hair can be de- again, that is, enters
So-called " minoxidil falls off the phase ".
For this purpose, while 5α-reductase can be inhibited there is an urgent need in the art to develop one kind, and side effect will not be generated
Chinese medicine hair nourishing hair growth liquor.
Summary of the invention
The application's is designed to provide a kind of good anti-drop effect, and drug withdrawal is not easy to take off again, without side-effects, and preparation process letter
Single Chinese medicine hair nourishing hair growth liquor containing angelica extract, to solve above-mentioned technical problem in the prior art.Specifically, originally
Application is related to a kind of Chinese medicine hair nourishing hair growth liquor composition containing angelica extract, is made by the mutual collaboration of nine kinds of active materials
With can improve scalp microcirculation, inhibit " 5α-reductase " effect, the activity of hair follicle cell is improved, to reach functions of nourishing hair and growing hair
Effect.
In order to solve the above-mentioned technical problem, the application provides following technical proposals:
In the first aspect, the application provides a kind of Chinese medicine hair nourishing hair growth liquor containing angelica extract, which is characterized in that
The Chinese medicine hair nourishing hair growth liquor includes the following effective components extracted from Chinese medicine material:
Angelica extract；
Shrubby sophora extract；
Cacumen Platycladi extract；
Salvia root P.E；
Rhizoma Chuanxiong extract；
Ginseng extract；
Radix-polygoni multiflori extract；
Rhizoma Gastrodiae extract；
Mulberries extract；With
Solvent.
In a kind of embodiment of first aspect, using the total weight of the Chinese medicine hair nourishing hair growth liquor as in terms of 100%, institute
Stating Chinese medicine hair nourishing hair growth liquor includes the following effective components extracted from Chinese medicine material:
The angelica extract of 0.15-0.25%；
The shrubby sophora extract of 0.3-0.4%；
The Cacumen Platycladi extract of 0.1-0.15%；
The Salvia root P.E of 0.15-0.25%；
The Rhizoma Chuanxiong extract of 0.15-0.25%；
The ginseng extract of 0.15-0.25%；
The radix-polygoni multiflori extract of 0.15-0.25%；
The Rhizoma Gastrodiae extract of 0.12-0.18%；
The mulberries extract of 0.12-0.18%；With
The solvent of surplus.
In a kind of embodiment of first aspect, the solvent is free volume than the second alcohol and water for 1:3~1:6
Mixture.
In a kind of embodiment of first aspect, the Chinese medicine hair nourishing hair growth liquor includes the Chinese medicine original from following weight parts
The effective component extracted in material: 10-100 parts of Radix Angelicae Sinensis, 10-80 parts of kuh-seng, 30-100 parts of cacumen biotae, 10-80 parts of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong
10-80 parts, 10-80 parts of ginseng, 10-100 parts of the fleece-flower root, 10-60 parts of Rhizoma Gastrodiae, 10-60 parts of mulberries；
Wherein, described extract includes the Chinese medicine material for mixing predetermined weight number, obtains Chinese medicine material mixture, then makes
Mixture with free volume than the second alcohol and water for 1:3~1:6 mentions the Chinese medicine material mixture by decocting method
It takes.
In a kind of embodiment of first aspect, the Chinese medicine hair nourishing hair growth liquor includes the Chinese medicine original from following weight parts
The effective component extracted in material: 20-100 parts of Radix Angelicae Sinensis, 20-80 parts of kuh-seng, 30-100 parts of cacumen biotae, 10-80 parts of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong
20-80 parts, 20-80 parts of ginseng, 10-100 parts of the fleece-flower root, 10-60 parts of Rhizoma Gastrodiae, 10-60 parts of mulberries；Wherein, described extract includes
The Chinese medicine material for mixing predetermined weight number, obtains Chinese medicine material mixture, then using free volume than for 1:3~1:6's
The mixture of second alcohol and water extracts the Chinese medicine material mixture by decocting method.
In a kind of embodiment of first aspect, the Chinese medicine hair nourishing hair growth liquor includes the Chinese medicine original from following weight parts
The effective component extracted in material: 40-60 parts of Radix Angelicae Sinensis, 30-50 parts of kuh-seng, 30-50 parts of cacumen biotae, 20-60 parts of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong 20-
60 parts, 30-50 parts of ginseng, 30-50 parts of the fleece-flower root, 15-30 parts of Rhizoma Gastrodiae, 20-30 parts of mulberries；Wherein, described extract includes mixing
The Chinese medicine material of predetermined weight number obtains Chinese medicine material mixture, then using free volume than the ethyl alcohol for 1:3~1:6
The Chinese medicine material mixture is extracted by decocting method with the mixture of water.
In a kind of embodiment of first aspect, the Chinese medicine hair nourishing hair growth liquor includes the Chinese medicine original from following weight parts
The effective component extracted in material: 20 parts of Radix Angelicae Sinensis, 30 parts of kuh-seng, 30 parts of cacumen biotae, 20 parts of Radix Salviae Miltiorrhizae, 20 parts of Rhizoma Chuanxiong, 20 parts of ginseng, what
20 parts of the tuber of multiflower knotweed, 15 parts of Rhizoma Gastrodiae, 15 parts of mulberries；Wherein, it is described extract include mixing predetermined weight number Chinese medicine material, obtain
Then medicine raw mixture passes through decocting method in described than the mixture of the second alcohol and water for 1:3~1:6 using free volume
Medicine raw mixture extracts.
In second aspect, it is feeding that the application provides a kind of Chinese medicine containing angelica extract prepared as described in relation to the first aspect
Occur lotion method, which is characterized in that the method includes by the Chinese medicine material according to effective component in each Chinese medicine material
Applicable extracting method is divided into several groups, extracts the effective component of every group of Chinese medicine material with suitable extracting method respectively, then
Every group of effective component extracted is mixed, the Chinese medicine hair nourishing hair growth liquor is made；Wherein every group of Chinese medicine material includes at least one
Chinese medicine material.
In a kind of embodiment of second aspect, the extracting method includes decocting method, ultrasonic extraction, microwave-assisted
One or more of extraction, water extraction and alcohol precipitation method, infusion process, circumfluence method, percolation or ethanol extraction method.
In a third aspect, it is feeding to provide a kind of Chinese medicine containing angelica extract prepared as described in relation to the first aspect by the application
The method of lotion occurs, which is characterized in that the method includes mixing the Chinese medicine material of predetermined weight number, obtain Chinese medicine material
Then mixture extracts the effective component in the Chinese medicine material mixture using suitable extracting method, removes to the maximum extent
After decontamination, the Chinese medicine hair nourishing hair growth liquor is obtained.
Compared with prior art, the beneficial effects of the present application are as follows Chinese medicine hair nourishing hair growth liquor of the invention, major embodiment
The inhibition " 5α-reductase " of Radix Angelicae Sinensis acts on, and passes through the mutual synergistic effect of nine kinds of active Chinese drug component substances, can improve scalp blood
Liquid microcirculation improves the activity of hair follicle cell, has the effect of functions of nourishing hair and growing hair.In addition, Chinese medicine hair nourishing hair growth liquor of the invention can
It is safe and non-stimulating for treating the crowds such as male's alopecia seborrheica, alopecia areata, whole alopecia, it prepares and easy to use；It root can be good for by force
Hair, effectively reduces and shaves one's head.
Detailed description of the invention
Presently filed embodiment is described in conjunction with the accompanying drawings, the application may be better understood, in attached drawing
In:
Fig. 1 is shown in the mouse hair follicles cell cultivated in normal cell culture fluid 20 days；
Fig. 2 shows mouse hair follicles cell of continuous addition allodihydrotestosterone (dihydrotestosterone DHT) after 20 days in culture solution；
Mouse in culture solution after Fig. 3 is shown functions of nourishing hair and growing hair liquid 10 days that continuously add a kind of embodiment according to the present invention
Hair follicle cell；
Mouse in culture solution after Fig. 4 is shown functions of nourishing hair and growing hair liquid 20 days that continuously add a kind of embodiment according to the present invention
Hair follicle cell；
Fig. 5 shows the forehead position before the functions of nourishing hair and growing hair liquid that a kind of embodiment according to the present invention is not used of example 1
Natural on-off cycles of hair growth situation；
Fig. 6 shows an example 1 forehead portion after using functions of nourishing hair and growing hair liquid 30 days of a kind of embodiment according to the present invention
Position natural on-off cycles of hair growth situation；
Fig. 7 shows the forehead position before the functions of nourishing hair and growing hair liquid that a kind of embodiment according to the present invention is not used of example 2
Natural on-off cycles of hair growth situation；
Fig. 8 shows an example 2 forehead portion after using functions of nourishing hair and growing hair liquid 20 days of a kind of embodiment according to the present invention
Position natural on-off cycles of hair growth situation；
Fig. 9 shows the crown position before the functions of nourishing hair and growing hair liquid that a kind of embodiment according to the present invention is not used of example 3
Natural on-off cycles of hair growth situation；And
Figure 10 shows an example 3 overhead after using functions of nourishing hair and growing hair liquid 20 days of a kind of embodiment according to the present invention
Position natural on-off cycles of hair growth situation.
Specific embodiment
In a specific embodiment, the application is specifically related to a kind of Chinese medicine hair nourishing hair tonic containing angelica extract
Liquid.The present composition accounts for composite formula are as follows: a, contains the angelica extract for accounting for functions of nourishing hair and growing hair liquid weight 0.15-0.25%；
B, containing the shrubby sophora extract for accounting for functions of nourishing hair and growing hair liquid weight 0.3-0.4%；C, containing accounting for functions of nourishing hair and growing hair liquid weight 0.1-0.15%
Cacumen Platycladi extract；D, containing the Salvia root P.E for accounting for functions of nourishing hair and growing hair liquid weight 0.15-0.25%；E, containing accounting for functions of nourishing hair and growing hair
The Rhizoma Chuanxiong extract of liquid weight 0.15-0.25%；F, containing the ginseng extract for accounting for functions of nourishing hair and growing hair liquid weight 0.15-0.25%；
G, containing the radix-polygoni multiflori extract for accounting for functions of nourishing hair and growing hair liquid weight 0.15-0.25%；H, containing accounting for functions of nourishing hair and growing hair liquid weight 0.12-
0.18% Rhizoma Gastrodiae extract；I contains the mulberries extract for accounting for functions of nourishing hair and growing hair liquid weight 0.12-0.18%.Chinese medicine of the present invention is supported
Lotion occurs, by the mutual synergistic effect of above nine kinds of active Chinese drug component substances, scalp blood microcirculation can be improved, inhibit " 5
5 alpha-reductases " effect, improves the activity of hair follicle cell, has compared with single active ingredient more rationally raw with more effective hair care
Breaking-out is used.
In a specific embodiment, the application provides a kind of Chinese medicine hair nourishing hair growth liquor containing angelica extract,
Be characterized in that, the functions of nourishing hair and growing hair liquid is made of following raw material effective component: 10-100 parts of Radix Angelicae Sinensis, 10-80 parts of kuh-seng,
30-100 parts of cacumen biotae, 10-80 parts of Radix Salviae Miltiorrhizae, 10-80 parts of Rhizoma Chuanxiong, 10-80 parts of ginseng, 10-100 parts of the fleece-flower root, Rhizoma Gastrodiae 10-60
Part, 10-60 parts of mulberries.
In a specific embodiment, the functions of nourishing hair and growing hair liquid of the application is made of following raw material effective component:
20-100 parts of Radix Angelicae Sinensis, 20-80 parts of kuh-seng, 30-100 parts of cacumen biotae, 10-80 parts of Radix Salviae Miltiorrhizae, 20-80 parts of Rhizoma Chuanxiong, 20-80 parts of ginseng,
10-100 parts of the fleece-flower root, 10-60 parts of Rhizoma Gastrodiae, 10-60 parts of mulberries.
In a specific embodiment, the functions of nourishing hair and growing hair liquid is made of following raw material effective component: when
Return 40-60 parts, 30-50 parts of kuh-seng, 30-50 parts of cacumen biotae, 20-60 parts of Radix Salviae Miltiorrhizae, 20-60 parts of Rhizoma Chuanxiong, 30-50 parts of ginseng, He Shou
30-50 parts black, 15-30 parts of Rhizoma Gastrodiae, 20-30 parts of mulberries.
In a specific embodiment, the functions of nourishing hair and growing hair liquid is made of following raw material effective component: when
Return 20 parts, 30 parts of kuh-seng, 30 parts of cacumen biotae, 20 parts of Radix Salviae Miltiorrhizae, 20 parts of Rhizoma Chuanxiong, 20 parts of ginseng, 20 parts of the fleece-flower root, 15 parts of Rhizoma Gastrodiae, mulberry
15 parts of Shen.
In a specific embodiment, the application provides a kind of method for preparing Chinese medicine hair nourishing hair growth liquor, and feature exists
In, the raw material is divided into several groups according to the property of effective component in each raw material, extract respectively raw material in every group it is effective at
Point, then every group of effective component extracted is mixed, the functions of nourishing hair and growing hair liquid is made, wherein having in every group at least one former
Material；Or the effective component of mixed all raw materials is extracted simultaneously, the functions of nourishing hair and growing hair liquid is made.
In a specific embodiment, the Chinese medicine hair nourishing hair growth liquor containing angelica extract of the application is by following weight
The effective component composition of part raw material: 10-100 parts of Radix Angelicae Sinensis, 10-80 parts of kuh-seng, 30-100 parts of cacumen biotae, 10-80 parts of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong
10-80 parts, 10-80 parts of ginseng, 10-100 parts of the fleece-flower root, 10-60 parts of Rhizoma Gastrodiae, 10-60 parts of mulberries.
In the functions of nourishing hair and growing hair raw material of above-mentioned technical solution, Radix Angelicae Sinensis has " 5α-reductase " for inhibiting to lead to alopecia
Effect, replenishing and activating blood provide nutrition abundant containing a variety of hydrocarbons and vitamine B group substance for hair follicle；Kuh-seng can press down
Make the effect of " 5α-reductase ", heat-clearing and damp-drying drug, reducing lipid and dredging collaterals, hair-growing and hair care；Cacumen biotae have tonify Qi of the kidney, growing and blacking hair
Effect, mentioning cacumen biotae in " dictionary of medicinal plant " plays the role of cooling blood and hemostasis, and for treating baldness, long-time service close can be sent out anti-
It is de-；Radix Salviae Miltiorrhizae QI invigorating salubrity, anti-oxidant, anti-aging, the effect of generating and nourishing hair；Rhizoma Chuanxiong has blood-activating and qi-promoting, and scalp blood is promoted to follow
The effect of ring；Ginseng has the function of reinforcing vital energy, tonifying spleen is calmed the nerves；The fleece-flower root has the function of supporing yang benefiting yin, blackening and generating hair；It
Fiber crops have the function of calming the liver kidney tonifying, anti-inflammatory hair tonic；Mulberries have the function of enrich blood enriching yin, fluid dryness, according in " the southern regions of the Yunnan Province book on Chinese herbal medicine "
It records, " kidney-nourishing dirty and controlling nocturnal emission with astringent drugs, the improving eyesight of long term usage dark hair ".The various traditional Chinese medicine ingredients of the present invention mutually act synergistically, and are able to suppress " 5 α-
The effect of reductase " improves scalp blood microcirculation, activates hair follicle, nutrition scalp, and strong root of hair reaches the strong hair of strong root, hair care
The effect of hair tonic.Above-mentioned all raw materials are directly to buy from pharmacy, i.e., processed dry medicinal material.The effective component of each raw material
Content passes through measuring, and good effect is shown in above-mentioned formula range.
In the above-mentioned technical solutions, since the chemical component of each raw material in functions of nourishing hair and growing hair liquid is more complicated, containing there are many have
Imitate ingredient and invalid components, it is therefore desirable to its effective component is extracted, to reach better phalacrosis prevention and hair generation effect.Extract hair care
When the effective component of hair growth liquor, following manner can be taken: several groups are divided into according to the property of effective component in each raw material, respectively
A kind of method (such as decocting method, ultrasonic extraction, microwave-assisted) can be used in the effective component for extracting raw material in every group
All components are extracted respectively, then every group of effective component extracted is mixed, the functions of nourishing hair and growing hair liquid is made, wherein in every group
With at least one raw material；Or the effective component of mixed all raw materials is extracted simultaneously, the functions of nourishing hair and growing hair liquid is made.
It is listed below the more preferred extracting method selected when extracting each material effective component respectively, wherein be applicable in
There are ethanol reflux extraction, water extraction and alcohol precipitation method, ultrasonic extracting method, decocting method in the extracting method of Radix Angelicae Sinensis effective component；It is applicable in
There are ethanol reflux extraction, water extraction and alcohol precipitation method, decocting method in the extracting method of kuh-seng；Extracting method suitable for cacumen biotae has second
Alcohol infusion process, supercritical carbon dioxide fluid extraction, decocting method；Extracting method suitable for Radix Salviae Miltiorrhizae has ultrasonic extraction, circumfluence method；It is applicable in
There are ethanol immersion, enzyme extraction method, decocting method in the extracting method of Rhizoma Chuanxiong；Extracting method suitable for ginseng has alcohol reflux to mention
It follows the example of, ultrasonic extraction, decocting method；Extracting method suitable for the fleece-flower root has ethanol extraction method, circumfluence method, decocting method；It is applicable in
There are soxhlet extraction, organic solvent extraction, decocting method in the extracting method of Rhizoma Gastrodiae；Extracting method suitable for mulberries has diacolation
Method, alcohol extracting method.The extracting method of each raw material of the above Chinese medicine is summarized, some methods are suitable for the extraction of several raw materials simultaneously, therefore
Can be with merging method, while plurality of raw materials effective component is extracted, to improve extraction efficiency.
After being extracted to functions of nourishing hair and growing hair liquid Chinese medicine material effective component, generally using isolation technics by Chinese medical extract with
The dregs of a decoction, sediment and solid impurity, solvent impurity are separated, to remove invalid components to the maximum extent, retain effectively at
Point and auxiliary element.Separation method of the invention has: centrifugal separation, sedimentation separation method are separated by filtration method and distillation cooling method.
As to above-mentioned technical proposal further progress optimize, the functions of nourishing hair and growing hair liquid by following raw material effectively at
It is grouped as: 10-100 parts of Radix Angelicae Sinensis, 10-80 parts of kuh-seng, 30-100 parts of cacumen biotae, 10-80 parts of Radix Salviae Miltiorrhizae, 10-80 parts of Rhizoma Chuanxiong, ginseng
10-80 parts, 10-100 parts of the fleece-flower root, 10-60 parts of Rhizoma Gastrodiae, 10-60 parts of mulberries.Functions of nourishing hair and growing hair liquid raw material is within the scope of this parts by weight
When, strengthen the hair hair-growing effects are most obvious, can be reduced the quantity shaved one's head.As the further improvement to above-mentioned technical proposal, institute
State the effective component that functions of nourishing hair and growing hair liquid includes following raw material: 40 parts of Radix Angelicae Sinensis, 40 parts of kuh-seng, 50 parts of cacumen biotae, Radix Salviae Miltiorrhizae 60
Part, 60 parts of Rhizoma Chuanxiong, 50 parts of ginseng, 50 parts of the fleece-flower root, 30 parts of Rhizoma Gastrodiae, 30 parts of mulberries.Obtained functions of nourishing hair and growing hair liquid has preferable
Strengthen the hair effect, test example show that the effective percentage of its hair growth accelerating is 58%.
Optimize as to above-mentioned technical proposal further progress, the functions of nourishing hair and growing hair liquid is by the effective of following raw material
At being grouped as: 20-100 parts of Radix Angelicae Sinensis, 20-80 parts of kuh-seng, 30-100 parts of cacumen biotae, 10-80 parts of Radix Salviae Miltiorrhizae, 20-80 parts of Rhizoma Chuanxiong, ginseng
20-80 parts, 10-100 parts of the fleece-flower root, 10-60 parts of Rhizoma Gastrodiae, 10-60 parts of mulberries.Functions of nourishing hair and growing hair liquid raw material is within the scope of this parts by weight
When, strengthen the hair hair-growing effects are most obvious, can be reduced the quantity shaved one's head.As the further improvement to above-mentioned technical proposal, institute
State the effective component that functions of nourishing hair and growing hair liquid includes following raw material: 60 parts of Radix Angelicae Sinensis, 50 parts of kuh-seng, 50 parts of cacumen biotae, Radix Salviae Miltiorrhizae 60
Part, 60 parts of Rhizoma Chuanxiong, 50 parts of ginseng, 50 parts of the fleece-flower root, 30 parts of Rhizoma Gastrodiae, 30 parts of mulberries.Obtained functions of nourishing hair and growing hair liquid has preferable
Strengthen the hair effect, test example show that the effective percentage of its hair growth accelerating is 63%.
Optimize as to above-mentioned technical proposal further progress, the functions of nourishing hair and growing hair liquid is by the effective of following raw material
At being grouped as: 40-60 parts of Radix Angelicae Sinensis, 30-50 parts of kuh-seng, 30-50 parts of cacumen biotae, 20-60 parts of Radix Salviae Miltiorrhizae, 20-60 parts of Rhizoma Chuanxiong, ginseng
30-50 parts, 30-50 parts of the fleece-flower root, 15-30 parts of Rhizoma Gastrodiae, 20-30 parts of mulberries.Functions of nourishing hair and growing hair liquid raw material is within the scope of this parts by weight
When, strengthen the hair hair-growing effects are most obvious, can be reduced the quantity shaved one's head.As the further improvement to above-mentioned technical proposal, institute
State the effective component that functions of nourishing hair and growing hair liquid includes following raw material: 40 parts of Radix Angelicae Sinensis, 40 parts of kuh-seng, 40 parts of cacumen biotae, Radix Salviae Miltiorrhizae 30
Part, 30 parts of Rhizoma Chuanxiong, 40 parts of ginseng, 30 parts of the fleece-flower root, 20 parts of Rhizoma Gastrodiae, 20 parts of mulberries.Obtained functions of nourishing hair and growing hair liquid can anti-avulsion it is solid
Hair, promotes hair follicle hair tonic, and test example shows that the effective percentage of its hair growth accelerating is 71%.
Optimize as to above-mentioned technical proposal further progress, the functions of nourishing hair and growing hair liquid is by the effective of following raw material
At being grouped as: 20 parts of Radix Angelicae Sinensis, 30 parts of kuh-seng, 30 parts of cacumen biotae, 20 parts of Radix Salviae Miltiorrhizae, 20 parts of Rhizoma Chuanxiong, 20 parts of ginseng, 20 parts of the fleece-flower root,
15 parts of Rhizoma Gastrodiae, 15 parts of mulberries.Obtained functions of nourishing hair and growing hair liquid has more apparent phalacrosis prevention and hair generation effect, and it is strong that new piliation is tough
Strong, test example shows that the effective percentage of its hair growth accelerating is 79%.
The present invention also provides a kind of preparation methods of functions of nourishing hair and growing hair liquid, by the raw material according to effective in each raw material
The property of ingredient is divided into several groups, extracts every group of effective component respectively, then mixes each effective component；Or mixing is extracted simultaneously
The functions of nourishing hair and growing hair liquid is made in the effective component of all raw materials afterwards.
As further improvement to above-mentioned technical proposal, the method for preparing the functions of nourishing hair and growing hair liquid are as follows: decocting method and second
The effective component for extracting mixed all raw materials is followed the example of in alcohol extracting.
As further improvement to above-mentioned technical proposal, prepare the method for the functions of nourishing hair and growing hair liquid the following steps are included:
1) weigh 1 part of compound Chinese medicine (radix sophorae: cacumen biotae: red sage root: Rhizoma Chuanxiong root: angelica root: ginseng: fleece-flower root root:
Its snippings: mulberry fruit), it is cleaned, be filtered dry after, dries pulverizing, cross 20-30 mesh；Add 10-20 times of its weight in herb powder
Free volume than for 1:3~1:6 second alcohol and water composition mix reagent, decoct 12-24 hours after, be filtered, gained
Filtrate is spare after recycling ethyl alcohol；
2) by filtrate obtained by step 1), packing is after sterilization to get functions of nourishing hair and growing hair liquid.
In a specific embodiment, the user of the Chinese medicine hair nourishing hair growth liquor as described herein containing angelica extract
Method is to rest generation lotion to be applied on scalp, and once in the morning and once at night, 10 days are 1 experimental period.
Embodiment
Below in conjunction with the embodiment of the present invention, clear and complete description is carried out to technical solution of the present invention.Such as nothing
It illustrates, reagent used and raw material can all be bought by commercial sources.Actual conditions are not specified in the following example
Experimental method according to conventional methods and conditions, or is selected according to product manual.
Prepare embodiment
Embodiment 1
A kind of Chinese medicine hair nourishing hair growth liquor containing angelica extract, is made of the effective component of following raw material: when
Return 40 parts, 40 parts of kuh-seng, 50 parts of cacumen biotae, 60 parts of Radix Salviae Miltiorrhizae, 60 parts of Rhizoma Chuanxiong, 50 parts of ginseng, 50 parts of the fleece-flower root, 30 parts of Rhizoma Gastrodiae, mulberry
30 parts of Shen.
The preparation method of the above Chinese medicine hair nourishing hair growth liquor, comprising the following steps:
Weigh 1 part of compound Chinese medicine (radix sophorae: cacumen biotae: red sage root: Rhizoma Chuanxiong root: angelica root: ginseng: fleece-flower root root: day
Snippings: mulberry fruit), it is cleaned, be filtered dry after, dries pulverizing, cross 20-30 mesh；Add 10-20 times of its weight in herb powder
Free volume is filtered after decocting 12-24 hours than the mix reagent of the second alcohol and water composition for 1:3~1:6, gained filter
Liquid, after recycling ethyl alcohol, packing is after sterilization to get functions of nourishing hair and growing hair liquid.
Embodiment 2
A kind of Chinese medicine hair nourishing hair growth liquor containing angelica extract, is made of the effective component of following raw material: when
Return 60 parts, 50 parts of kuh-seng, 50 parts of cacumen biotae, 60 parts of Radix Salviae Miltiorrhizae, 60 parts of Rhizoma Chuanxiong, 50 parts of ginseng, 50 parts of the fleece-flower root, 30 parts of Rhizoma Gastrodiae, mulberry
30 parts of Shen.
The preparation method is the same as that of Example 1 for the Chinese medicine hair nourishing hair growth liquor of the present embodiment.
Embodiment 3
A kind of Chinese medicine hair nourishing hair growth liquor containing angelica extract, is made of the effective component of following raw material: when
Return 40 parts, 40 parts of kuh-seng, 40 parts of cacumen biotae, 30 parts of Radix Salviae Miltiorrhizae, 30 parts of Rhizoma Chuanxiong, 40 parts of ginseng, 30 parts of the fleece-flower root, 20 parts of Rhizoma Gastrodiae, mulberry
20 parts of Shen.
The preparation method is the same as that of Example 1 for the Chinese medicine hair nourishing hair growth liquor of the present embodiment.
Embodiment 4
A kind of Chinese medicine hair nourishing hair growth liquor containing angelica extract, is made of the effective component of following raw material: when
Return 20 parts, 30 parts of kuh-seng, 30 parts of cacumen biotae, 20 parts of Radix Salviae Miltiorrhizae, 20 parts of Rhizoma Chuanxiong, 20 parts of ginseng, 20 parts of the fleece-flower root, 15 parts of Rhizoma Gastrodiae, mulberry
15 parts of Shen.
The preparation method is the same as that of Example 1 for the Chinese medicine hair nourishing hair growth liquor of the present embodiment.
Effect example
C57BL6 mouse experiment
The experiment condition of mouse experiment is as follows:
Microscope model XSP-13CC biomicroscope is purchased from Shanghai Cai Kang optical instrument Co., Ltd.
Mouse experiment culture device is cell incubator (Heracell VIOS 250i matches silent winged generation that).Cell culture
Condition is as follows: temperature (37 DEG C), CO2Horizontal (5%), pH value (pH value: 7.2-7.4), relative saturation humidity (95%).
Mouse cell is C57BL6 back of mice hair follicle cell.Cell culture fluid is that William culture medium adds glutamine
2mmol/L, Hepes2mmol/L, hydrocortisone 10ng/mL, bovine insulin 10ug/mL, transferrins 10ug/mL, selenous acid
Sodium 10ug/mL, penicillin 100U/mL, streptomysin 100ug/mL.
Mouse experiment cell culture fluid volume: 48 orifice plates, volume are the hole 140ul/, hair follicle cell initial concentration: 1.2*105
A cell.
By the evaluation of C57BL6 mouse experiment according to Chinese medicine hair nourishing hair growth liquor hair tonic the effect of property of embodiment 4: taking
C57BL6 mouse 24, the age at 30-42 day, back of mice hair is rejected, hair follicle cell is separated, and takes 1ul allodihydrotestosterone (dihydro
Testosterone DHT) or 1ul functions of nourishing hair and growing hair liquid sample, it makes an addition in cell culture fluid respectively, it is sooner or later respectively plus primary, continuously cultivate 20
It, every 10 days with high-power microscope (microscope model: XSP-13CC biomicroscope, Shanghai Cai Kang optical instrument Co., Ltd)
Mouse hair follicles cell is recorded, the case where hair follicle newly grows hair is observed.
Mouse hair tonic result is referring to Fig. 1 to Fig. 4, and wherein Fig. 1 is shown in the mouse cultivated in normal cell culture fluid 20 days
Hair follicle cell；Mouse hair follicles cell after Fig. 2 is shown continuous addition allodihydrotestosterone 20 days in culture solution；Fig. 3 shows continuous addition originally
Mouse hair follicle cell in culture solution behind functions of nourishing hair and growing hair liquid 10 days of invention；Fig. 4, which is shown, continuously adds functions of nourishing hair and growing hair liquid of the invention
Mouse hair follicle cell in culture solution after 20 days.Functions of nourishing hair and growing hair liquid of the invention can be effectively suppressed " 5 it can be seen from Fig. 1 to Fig. 4
5 alpha-reductases ", hair follicle cell bears tiny hair after 10 days, and hair follicle cell number of hairs becomes more after 20 days, and diameter of hair is thicker；
Its strengthen the hair hair tonic has more significant effect.
Individual experiment
Select an example 1 (35 years old, female), a example 2 (42 years old, male) and example 3 (30 years old, male) use according to embodiment 4 respectively
The Chinese medicine hair nourishing hair growth liquor containing angelica extract.Application method is to rest generation lotion to be applied on scalp, the morning and evening each one
Secondary, 10 days are 1 experimental period.Pass through scalp microscope (Portable 50-500X 2MP Light Digital
Microscope, Fei Chao Science and Technology Ltd. of Shenzhen) observation hair state.
Fig. 5 and Fig. 6 is Contrast on effect of the functions of nourishing hair and growing hair liquid of the present invention to a example 1 in individual test example using 30 days front and backs
Figure；Where figure 5 depicts the forehead position natural on-off cycles of hair growth situation before using, Fig. 6 shows raw using the hair at rear forehead position
Long situation, hence it is evident that visible use is preceding without new hair is grown at hair after use, becomes sturdy using preceding fine hair on birds or animals hair.
Fig. 7 and Fig. 8 is Contrast on effect of the functions of nourishing hair and growing hair liquid of the present invention to a example 2 in individual test example using 20 days front and backs
Figure；Wherein Fig. 7 shows the forehead position natural on-off cycles of hair growth situation before use, and Fig. 8 shows raw using the hair at rear forehead position
Long situation, hence it is evident that visible alopecia effect is improved, and the soft hair before use, secured using rear root of hair, hair becomes pitch-black
It is tough and tensile.
Fig. 9 and Figure 10 is effect pair of the functions of nourishing hair and growing hair liquid of the present invention to a example 3 in individual test example using 20 days front and backs
Than figure；Wherein Fig. 9 shows the overhead position natural on-off cycles of hair growth situation before use, and Figure 10 shows the hair using position at the top of back
Growing state, hence it is evident that as it can be seen that bearing 1-2 root hair using preceding 1 hair follicle, 1 hair follicle grows 2-3 root hair, and hair after use
It is thicker to send out diameter, goes out new hair without hair director originally.
Population experiment example:
The first step, choose the alopecia areatas of 96 22-52 years old age brackets, whole alopecia, bald crowd (30 people of alopecia areata, 24 people of whole alopecia,
Bald 42 people) as object on probation；Wherein male 56 people, 40 people of female；Multiselect testing crew is randomly divided into first, second, third and fourth
Group, every group of 24 people try out prepared by embodiment 1, embodiment 2, embodiment 3 and embodiment 4 for first, second, third and fourth group respectively and support
Lotion, application method occurs are as follows: rest generation lotion and be applied on scalp, once in the morning and once at night (altogether using 3 experimental periods
30 days)；
Second step, the standard of curative effect evaluation: a) significant effective: alopecia is obviously improved, and disconnected hair significant amounts of shaving one's head are reduced, no hair
Area obviously grows hair, and root of hair is securely tough and tensile；B) effectively: alopecia has improvement sign, and disconnected hair quantity of shaving one's head is reduced, no hair head of district
Fine hair on birds or animals hair out, but not enough securely, a drawing is i.e. disconnected；C) do not have effect: depilation phenomenon does not improve and mitigates, and Wu Faqu, which can not be grown, to lift one's head
Hair.
Specific data are shown in Table 1:
The above-mentioned description to embodiment is that this Shen can be understood and applied for the ease of those skilled in the art
Please.Person skilled in the art obviously easily can make various modifications to these embodiments, and described herein
General Principle is applied in other embodiments without paying creative labor.Therefore, the application is not limited to implementation here
Example, those skilled in the art make according to herein disclosed content in the case where not departing from the application scope and spirit
It improves and modifies within all scope of the present application.
Claims (10)
1. a kind of Chinese medicine hair nourishing hair growth liquor containing angelica extract, which is characterized in that the Chinese medicine hair nourishing hair growth liquor include from
The following effective components extracted in Chinese medicine material:
Angelica extract；
Shrubby sophora extract；
Cacumen Platycladi extract；
Salvia root P.E；
Rhizoma Chuanxiong extract；
Ginseng extract；
Radix-polygoni multiflori extract；
Rhizoma Gastrodiae extract；
Mulberries extract；With
Solvent.
2. the Chinese medicine hair nourishing hair growth liquor containing angelica extract as described in claim 1, which is characterized in that supported with the Chinese medicine
The total weight of lotion occurs as 100% meter, the Chinese medicine hair nourishing hair growth liquor is following effective comprising what is extracted from Chinese medicine material
Ingredient:
The angelica extract of 0.15-0.25%；
The shrubby sophora extract of 0.3-0.4%；
The Cacumen Platycladi extract of 0.1-0.15%；
The Salvia root P.E of 0.15-0.25%；
The Rhizoma Chuanxiong extract of 0.15-0.25%；
The ginseng extract of 0.15-0.25%；
The radix-polygoni multiflori extract of 0.15-0.25%；
The Rhizoma Gastrodiae extract of 0.12-0.18%；
The mulberries extract of 0.12-0.18%；With
The solvent of surplus.
3. the Chinese medicine hair nourishing hair growth liquor containing angelica extract as claimed in claim 1 or 2, which is characterized in that the solvent
Mixture for free volume than the second alcohol and water for 1:3~1:6.
4. the Chinese medicine hair nourishing hair growth liquor containing angelica extract as described in claim 1, which is characterized in that the Chinese medicine hair nourishing
Hair growth liquor includes the effective component extracted from the Chinese medicine material of following weight parts: 10-100 parts of Radix Angelicae Sinensis, 10-80 parts of kuh-seng, side
30-100 parts of CedarLeaves, 10-80 parts of Radix Salviae Miltiorrhizae, 10-80 parts of Rhizoma Chuanxiong, 10-80 parts of ginseng, 10-100 parts of the fleece-flower root, 10-60 parts of Rhizoma Gastrodiae,
10-60 parts of mulberries；
Wherein, described extract includes the Chinese medicine material for mixing predetermined weight number, obtains Chinese medicine material mixture, then using certainly
The Chinese medicine material mixture is extracted by decocting method by the mixture for the second alcohol and water that volume ratio is 1:3~1:6.
5. the Chinese medicine hair nourishing hair growth liquor containing angelica extract as described in claim 1, which is characterized in that the Chinese medicine hair nourishing
Hair growth liquor includes the effective component extracted from the Chinese medicine material of following weight parts: 20-100 parts of Radix Angelicae Sinensis, 20-80 parts of kuh-seng, side
30-100 parts of CedarLeaves, 10-80 parts of Radix Salviae Miltiorrhizae, 20-80 parts of Rhizoma Chuanxiong, 20-80 parts of ginseng, 10-100 parts of the fleece-flower root, 10-60 parts of Rhizoma Gastrodiae,
10-60 parts of mulberries；
Wherein, described extract includes the Chinese medicine material for mixing predetermined weight number, obtains Chinese medicine material mixture, then using certainly
The Chinese medicine material mixture is extracted by decocting method by the mixture for the second alcohol and water that volume ratio is 1:3~1:6.
6. the Chinese medicine hair nourishing hair growth liquor containing angelica extract as described in claim 1, which is characterized in that the Chinese medicine hair nourishing
Hair growth liquor includes the effective component extracted from the Chinese medicine material of following weight parts: 40-60 parts of Radix Angelicae Sinensis, 30-50 parts of kuh-seng, arbor-vitae
30-50 parts of leaf, 20-60 parts of Radix Salviae Miltiorrhizae, 20-60 parts of Rhizoma Chuanxiong, 30-50 parts of ginseng, 30-50 parts of the fleece-flower root, 15-30 parts of Rhizoma Gastrodiae, mulberries
20-30 parts；
Wherein, described extract includes the Chinese medicine material for mixing predetermined weight number, obtains Chinese medicine material mixture, then using certainly
The Chinese medicine material mixture is extracted by decocting method by the mixture for the second alcohol and water that volume ratio is 1:3~1:6.
7. the Chinese medicine hair nourishing hair growth liquor containing angelica extract as described in claim 1, which is characterized in that the Chinese medicine hair nourishing
Hair growth liquor includes the effective component extracted from the Chinese medicine material of following weight parts: 20 parts of Radix Angelicae Sinensis, 30 parts of kuh-seng, cacumen biotae 30
Part, 20 parts of Radix Salviae Miltiorrhizae, 20 parts of Rhizoma Chuanxiong, 20 parts of ginseng, 20 parts of the fleece-flower root, 15 parts of Rhizoma Gastrodiae, 15 parts of mulberries；
Wherein, described extract includes the Chinese medicine material for mixing predetermined weight number, obtains Chinese medicine material mixture, then using certainly
The Chinese medicine material mixture is extracted by decocting method by the mixture for the second alcohol and water that volume ratio is 1:3~1:6.
8. a kind of side for preparing the Chinese medicine hair nourishing hair growth liquor as of any of claims 1-7 containing angelica extract
Method, which is characterized in that the extraction side that the method includes being applicable in the Chinese medicine material according to effective component in each Chinese medicine material
Method is divided into several groups, extracts the effective component of every group of Chinese medicine material with suitable extracting method respectively, then extracts every group
Effective component mixing, is made the Chinese medicine hair nourishing hair growth liquor；
Wherein every group of Chinese medicine material includes at least one Chinese medicine material.
9. method according to claim 8, which is characterized in that the extracting method includes decocting method, ultrasonic extraction, microwave
One or more of auxiliary extraction method, water extraction and alcohol precipitation method, infusion process, circumfluence method, percolation or ethanol extraction method.
10. a kind of side for preparing the Chinese medicine hair nourishing hair growth liquor as of any of claims 1-7 containing angelica extract
Method, which is characterized in that the method includes mixing the Chinese medicine material of predetermined weight number, obtain Chinese medicine material mixture, then
The effective component in the Chinese medicine material mixture is extracted using suitable extracting method, after removing impurity to the maximum extent, is obtained
To the Chinese medicine hair nourishing hair growth liquor.
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| CN113633752A (en) * | 2021-09-28 | 2021-11-12 | 霸州市巨隆生物科技有限公司 | Traditional Chinese medicine composition for hair care and hair growth |
| CN113952394A (en) * | 2021-11-27 | 2022-01-21 | 随成业 | Traditional Chinese medicine composition for hair care and hair nourishing and hair whitening and blackening and preparation method thereof |
| CN116920053A (en) * | 2023-09-01 | 2023-10-24 | 海南医学院 | Natural herbal traditional Chinese medicine composition for treating oily alopecia and extraction preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110538119A (en) * | 2019-05-14 | 2019-12-06 | 云南民族大学 | Rhizoma gastrodiae hair growth essence stock solution and preparation method thereof |
| CN113633752A (en) * | 2021-09-28 | 2021-11-12 | 霸州市巨隆生物科技有限公司 | Traditional Chinese medicine composition for hair care and hair growth |
| CN113952394A (en) * | 2021-11-27 | 2022-01-21 | 随成业 | Traditional Chinese medicine composition for hair care and hair nourishing and hair whitening and blackening and preparation method thereof |
| CN116920053A (en) * | 2023-09-01 | 2023-10-24 | 海南医学院 | Natural herbal traditional Chinese medicine composition for treating oily alopecia and extraction preparation method |
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