CN108743729A - A kind of herb composition that treating alopecia seborrheica and nanometer hair nourishing liquid - Google Patents

A kind of herb composition that treating alopecia seborrheica and nanometer hair nourishing liquid Download PDF

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Publication number
CN108743729A
CN108743729A CN201810614411.8A CN201810614411A CN108743729A CN 108743729 A CN108743729 A CN 108743729A CN 201810614411 A CN201810614411 A CN 201810614411A CN 108743729 A CN108743729 A CN 108743729A
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China
Prior art keywords
hair
parts
root
alopecia
fleece
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CN201810614411.8A
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Inventor
曹晖
吴孟华
张英
周光兵
戎建群
赵锴
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Guangzhou Bijing Biotechnology Co Ltd
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Guangzhou Bijing Biotechnology Co Ltd
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Priority to CN201810614411.8A priority Critical patent/CN108743729A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K36/82—Theaceae (Tea family), e.g. camellia
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755—Gymnosperms [Coniferophyta]
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    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
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    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

The invention discloses a kind of herb composition for treating alopecia seborrheica and nanometer hair nourishing liquids.The herb composition includes the component of following parts by weight：10~50 parts of the fleece-flower root, 10~50 parts of angelica root, 10~50 parts of ginseng, 10~50 parts of cacumen biotae, 1~15 part of tea seed cake, 1~15 part of Chinese gall.In addition, the herb composition of the present invention, further includes nanoemulsions.The composition of the present invention has played apparent synergistic effect, and using herbaceous plant as raw material, complete square compatibility 5 is reasonable, with apparent antibacterial, inhibition trichomadesis, trichogenous effect, the weight and length of new piliation can be increased, fundamentally improve alopecia symptom, it dispels oil, debris removing, antipruritic, firm root of hair effectively treats alopecia seborrheica to achieve the purpose that preferably anticreep, promotion hair health growth.Preparation method of the present invention is simple, of low cost, can be applied to various hair products, and application prospect is good.

Description

A kind of herb composition that treating alopecia seborrheica and nanometer hair nourishing liquid
Technical field
The present invention relates to hair washing product technical fields, more particularly, to a kind of draft for treating alopecia seborrheica Composition and nanometer hair nourishing liquid.
Background technology
Alopecia at present oneself through becoming both at home and abroad clinically common skin disease, the health promulgated according to national departments concerned refers to It counts, alopecia incidence is up to 30% in Chinese adult crowd.Alopecia seborrheica is also known as male pattern alopecia, androgenic baldness, Chinese medicine is referred to as alopecia seborrhoeica, alopecia seborrheica, and clinical manifestation is the crown and the alopecia of forehead both sides, and hair oil head is itched, consider to be worth doing more, have it is bright Aobvious scratchiness, is apt to occur in male adults.Alopecia seborrheica hinders appearance, influences beauty, often brings huge spirit to patient Pressure and psychological burden, this disease are also common disease, the frequently-occurring disease of dept. of dermatology, are one of refractory diseases.It is counted according to authoritative institution, The ratio that 25~35 years old man in China suffers from male pattern alopecia is up to 40%, and total number of persons alreadys exceed 1.5 hundred million；Alopecia just shows year The trend gently changed, 84.8% is diagnosed as alopecia seborrheica.
At present for alopecia seborrheica, the primary treatment approach of doctor trained in Western medicine is by inhibiting male hormone metabolism enzyme or acting on hero Hormone receptor, prevents androgen in target organ expression activity, and current clinically used drug includes：Finasteride, fluorine sieve ground you With minoxidil etc..Although these drugs have certain effect to treatment alopecia seborrheica to a certain extent, these drugs There are many side effects, and for example slight dysfunction of liver of considerable distress, sex dysfunction, middle severe depression, mood are brought to patient Disorderly, sleep and eating habit are abnormal etc..
Traditional Chinese medicine thinks that seborrhea dermatoses are common with syndrome of deficiency of kidney yin, and sebum category kidney is hidden.The deficiency of the kidney yin, the fiery mistake of phase It is prosperous, it is disturbed in the fire of deficiency type, compels the excessive skin of essence, fur, then hypersteatosis.Heat accumulates fur, strongly fragrant and change wind then pruitus.It is many Studies have shown that the scanning electron microscopic observation of alopecia seborrheica patient's hair, the infection of the variation and bacterium of its pathologic structure is found It is directly related.Mainly there is ZHANGGUANG 101 for alopecia seborrheica Chinese traditional treatment externally applied drug at present, disappear and send out tincture, Sibai hair tonic wiping humorously Some Chinese medical extracts such as agent, though obtaining certain curative effect, there are degreasing reagents, such as ethyl alcohol in these external used medicines, to scalp There are certain damage and stimulations, meanwhile, Medicated Permeation ability is poor, and there are certain limitations for therapeutic effect.
Therefore, it is extremely urgent to develop a kind of product that can be directed to treatment alopecia seborrheica.
Invention content
It is an object of the invention to overcome above-mentioned the deficiencies in the prior art, a kind of draft group for treating alopecia seborrheica is provided Close object and nanometer hair nourishing liquid.The present invention has apparent antibacterial, inhibition trichomadesis, trichogenous effect, Ke Yizeng Add the weight and length of new piliation.
The object of the present invention is to provide a kind of herb compositions for treating alopecia seborrheica.
It is a further object of the present invention to provide a kind of nanometer hair nourishing liquids for treating alopecia seborrheica.
Another object of the present invention be to provide above-mentioned herb composition or nanometer hair nourishing liquid prepare promote hair growth and/ Or the application in the product of inhibition alopecia.
Above-mentioned purpose of the present invention is achieved through the following technical solutions：
A kind of herb composition for treating alopecia seborrheica, includes the component of following parts by weight：The fleece-flower root 10~50 Part, 10~50 parts of angelica root, 10~50 parts of ginseng, 10~50 parts of cacumen biotae, 1~15 part of tea seed cake, 1~15 part of Chinese gall.
In the composition of the present invention, certain hematopoietic growths of fibroblasts to secrete that angelica root passes through induction of hematopoiesis microenvironment The factor, to promote hematopoietic cell proliferation to break up.The fleece-flower root has anti-aging, Wu Sifa, pleases color, the effect of strengthening the essence blood-nourishing, Hair cell can be promoted newborn, slow down white hair growth, prevent hair loss, to seborrhea, dandruff is excessive, and itching of the scalp has centainly Curative effect, in addition to this, rich in trace element necessary to the natural on-off cycles of hair growth such as iron, zinc, violent, also containing 3.7% lecithin, energy Promote new life and the development of cell.Cacumen biotae has the effect of cooling blood and hemostasis, growing and blacking hair.Ginseng, which has, to reinforce vital energy, multiple The effect of arteries and veins prevent prolapse, reinforces the spleen to benefit the lung, and promotes the production of body fluid, tranquilizing the mind.Chinese gall has the function of convergence, antibacterial, removing toxic substances.Contain tea soap in tea seed cake Element, protein, natural tea oil etc., long-time service, which has, only considers to be worth doing, is antipruritic, deoils, sterilize, repairing the effect of damaged hair, also bright Aobvious black hair, hair regrowth, are best one of the detergents of the Nature.Several component compoundings can play apparent synergy Effect.
And the present invention uses herbaceous plant as active ingredient, and property is mild, safe and non-stimulating, fully maintains natural The activity of plant can increase new piliation in use, inhibiting trichomadesis, trichogenous effect with apparent Weight and length, from the root cause improve hair ecology, effectively treat alopecia seborrheica.
Preferably, the herb composition includes the component of following parts by weight：20~40 parts of the fleece-flower root, angelica root 20 ~40 parts, 10~30 parts of ginseng, 20~40 parts of cacumen biotae, 5~12 parts of tea seed cake, 5~12 parts of Chinese gall.
It is highly preferred that the herb composition includes the component of following parts by weight：30 parts of the fleece-flower root, angelica root 30 Part, 20 parts of ginseng, 30 parts of cacumen biotae, 10 parts of tea seed cake, 10 parts of Chinese gall.
Furthermore it is preferred that above-mentioned herb composition further includes nanoemulsions；The grain size of the nanoemulsions is not more than 200nm (preferably 1~200nm).Herb composition of the present invention is imitated after local topical using the small size of nano particle It answers, effective component of chinese medicine can be carried, penetrate into scalp deep layer and hair follicle rapidly, activate hair follicle, boost metabolism, fully send out The synergistic effect for waving herb composition and nanoemulsions reaches additional issue, educates hair effect, supplement natural on-off cycles of hair growth needed for nutrition at Point, fundamentally improve alopecia symptom, oil of dispelling, debris removing, antipruritic, firm root of hair are strong to reach preferably anticreep, promotion hair The purpose of Kang Shengchang.
It is highly preferred that by weight percentage, the nanoemulsions include：Emulsifier 2~10%, moisturizer 3~7%, Preservative 0.4~0.5%, deodorant tune 0.3~0.5%, surplus are deionized water.
It is further preferred that by weight percentage, the nanoemulsions include：Emulsifier 6%, is prevented at moisturizer 5% Rotten agent 0.4~0.5%, deodorant tune 0.3~0.5%, surplus are deionized water.
Preferably, the emulsifier is lecithin, polysorbas20 or vitamin E polyethylene glycol succinic acid ester；The guarantor Humectant is glycerine, mineral oil or sodium hyaluronate；The preservative is bi-imidazolidinyl urea, Phenoxyethanol or tea tree ethereal oil class anti-corrosion Agent；The deodorant tune is essence.
In the present invention, preferred emulsifier is lecithin.Lecithin is nonirritant to scalp, and be otherwise known as lecithin, It is known as " third nutrient " arranged side by side with protein, vitamin, with emulsification, cut grease effect, can promote blood circulation, Improve serum lipids, remove peroxide, Blood Cholesterol and neutral fat content is made to reduce, reduces fat wall in the blood vessels Residence time, promote atherosis spot dissipation, prevent the blood vessel internal membrane damage caused by cholesterol.In addition, lecithin is also Have the function of the main nutrient of Palmitoleic Acid, contained inositol or hair, alopecia can be inhibited, makes white hair slowly blackening.
In the present invention, preferred moisturizer is glycerine can moisten scalp with good moisturizing moisten effect.
Herb composition of the present invention can be prepared into external preparation with pharmaceutically acceptable carrier.
The pharmaceutically acceptable carrier includes but not limited to：Surfactant, buffer substance, electrolyte and its His common excipient substance such as adhesive (such as microcrystalline cellulose), sorbefacient, absorption carrier, excipient, diluent, wetting Agent etc..
The herb composition of the present invention can be prepared into various dosage forms according to a conventional method, in order to use.
Preferably, the external preparation includes but not limited to washing lotion, essence, ointment, gel, patch, tincture or spraying The regular dosage form pharmaceutically such as agent.
The present invention also provides a kind of nanometer hair nourishing liquids for treating alopecia seborrheica, by method comprising the following steps system It is standby to obtain：
S1. the fleece-flower root, angelica root, ginseng, cacumen biotae, tea seed cake and Chinese gall are carried with Extraction solvent It takes, obtains drug extract；
S2. obtained drug extract and the nano-emulsion liquid phase made of the emulsifier, moisturizer and water are mixed It closes, the preservative and deodorant tune is added to get nanometer hair nourishing liquid.
Preferably, the Extraction solvent is water, ethyl alcohol, or the mixture for water and ethyl alcohol.
Preferably, the nanometer hair nourishing liquid of the treatment alopecia seborrheica, is prepared by method comprising the following steps It arrives：
S1. the fleece-flower root, angelica root, ginseng, cacumen biotae, tea seed cake and Chinese gall are crushed according to different weight ratio Afterwards, be added 7~9 times of weight water, impregnate 20~40min after, 80~100 DEG C decoct extraction 2 times, every time decoct 20~ 40min obtains drug extract；Drug extract is merged, is concentrated, alcohol precipitation, 12~36h of standing, recycling ethyl alcohol to no alcohol taste, Obtain medicinal material medicinal extract；
S2. by obtained medicinal material medicinal extract and the (control of the nanoemulsions made of the emulsifier, moisturizer and water The average grain diameter of nanoemulsions is 105~115nm, preferably 110nm) it mixes, the preservative and deodorant tune is added, i.e., Obtain nanometer hair nourishing liquid.
Above-mentioned herb composition or above-mentioned nanometer hair nourishing liquid are preparing the production for promoting hair growth and/or inhibiting alopecia Application in product is within protection scope of the present invention.
The product can be made into various forms, such as including hair cream, shampoo, hair dye, hair conditioner or support The forms such as lotion, in order to use.
Compared with prior art, the present invention has the advantages that：
The present invention is using herbaceous plant as raw material, and complete square compatibility 5 is reasonable, by the fleece-flower root, angelica root, ginseng, cacumen biotae, tea The dregs of rice and Chinese gall share, and have played the effect of significant synergy, have apparent antibacterial, inhibition trichomadesis, promotion hair Long effect occurs, the weight and length of new piliation can be increased, improves hair ecology from the root cause, effectively treats seborrheica Alopecia.
The composition and its prepared product for improving hair-growing preparation method of the present invention is simple, of low cost, in Anti-hair loss, hair tonic It is a great discovery in research, upper in application is also a quantum jump, can meet the needs of people are to anti-hair loss products, solve alopecia Considerable economic benefit can be created again to the application of the worry that modern brings, while the present invention.
Description of the drawings
Fig. 1 is the grain size distribution of 1 nanometer of hair nourishing liquid of embodiment.
Fig. 2 is the scoring event of the 21st day newborn hair growth situation after different disposal group mouse loses hair or feathers.
Fig. 3 is (general to the scoring figure of the new piliation in mouse alopecia of chemical origin area during being different hair nourishing liquid medications 10~20 days Logical hair nourishing liquid refers to not adding nanoemulsions hair nourishing liquid made of Chinese medicine hair cream).
Fig. 4 is after different hair nourishing liquid medications 20 days to mouse alopecia of chemical origin area hair average weight figure.
Fig. 5 is after different hair nourishing liquid medications 20 days to mouse alopecia of chemical origin area hair length figure.
Specific implementation mode
Further illustrated the present invention below in conjunction with specific embodiment, but embodiment the present invention is not done it is any type of It limits.Unless stated otherwise, the present invention uses reagent, method and apparatus is the art conventional reagent, methods and apparatus.
Unless stated otherwise, following embodiment agents useful for same and material are purchased in market.
A kind of nanometer hair nourishing liquid that treating alopecia seborrheica of embodiment 1
1, preparation method
(1) fleece-flower root 30g, angelica root 30g, ginseng 20g, cacumen biotae 30g, tea seed cake 10 g and Chinese gall 10g are taken respectively It puts into pulverizer, coarse crushing is at coarse powder；Medicinal material coarse powder is placed in extractor, the water of 8 times of weight is added, impregnates 30min, is decocted Boil extraction 2 times, each 30min；Merge decoction liquor twice, filtering, merging filtrate concentrates, alcohol precipitation, stands for 24 hours, revolving recycling Ethyl alcohol obtains medicinal material medicinal extract to no alcohol taste；
(2) obtained medicinal material medicinal extract is added to and is mixed by 5% glycerine, 6% lecithin and 81% water ultrasonic agitation In nanoemulsions, with deionized water constant volume, it is then added 0.4% Bis(hydroxymethyl)imidazolidinyl urea, 0.3% essence is to get receiving Rice hair nourishing liquid, and it is stored refrigerated in 4 DEG C.
2, as shown in Figure 1, the grain size of nanometer hair nourishing liquid product obtained is less than 200nm, there is preferable targeting, carry The high ability of skin permeation, smear 20 Tian Hou alopecias area natural on-off cycles of hair growth length of nanometer hair nourishing liquid and weight have compared with blank group it is aobvious It writes and improves, 31.2% and 75.1% has been respectively increased, illustrate that the nanometer hair nourishing liquid prepared has preferable hair regrowth.
1 nanometer of hair nourishing liquid of table is to several inhibitions for representing bacterium in scalp
As shown in Table 1, for this nanometer of hair nourishing liquid using after 20min, bacteriostasis rate illustrates the nanometer of the present invention up to 97% or more Hair nourishing liquid has good fungistatic effect.
A kind of nanometer hair nourishing liquid that treating alopecia seborrheica of embodiment 2
Preparation method：
(1) fleece-flower root 30g, angelica root 20g, ginseng 20g, cacumen biotae 30g, 10 g of tea seed cake and Chinese gall 5g is taken to throw respectively Enter in pulverizer, coarse crushing is at coarse powder；Medicinal material coarse powder is placed in extractor, the water of 8 times of weight is added, impregnates 30min, is decocted Extraction 2 times, each 30min；Merge decoction liquor twice, filtering, merging filtrate concentrates, alcohol precipitation, stands for 24 hours, revolving recycling second Alcohol obtains medicinal material medicinal extract to no alcohol taste；
(2) obtained medicinal material medicinal extract is added to and is mixed by 5% glycerine, 6% lecithin and 81% water ultrasonic agitation In nanoemulsions, with deionized water constant volume, it is then added 0.4% Bis(hydroxymethyl)imidazolidinyl urea, 0.3% essence is to get receiving Rice hair nourishing liquid, and it is stored refrigerated in 4 DEG C.
A kind of nanometer hair nourishing liquid that treating alopecia seborrheica of embodiment 3
Preparation method：
(1) fleece-flower root 20g, angelica root 30g, ginseng 10g, cacumen biotae 30g, 10 g of tea seed cake and Chinese gall 5g is taken to throw respectively Enter in pulverizer, coarse crushing is at coarse powder；Medicinal material coarse powder is placed in extractor, the water of 8 times of weight is added, impregnates 30min, is decocted Extraction 2 times, each 30min；Merge decoction liquor twice, filtering, merging filtrate concentrates, alcohol precipitation, stands for 24 hours, revolving recycling second Alcohol obtains medicinal material medicinal extract to no alcohol taste；
(2) obtained medicinal material medicinal extract is added to and is mixed by 5% glycerine, 6% lecithin and 81% water ultrasonic agitation In nanoemulsions, with deionized water constant volume, it is then added 0.4% Bis(hydroxymethyl)imidazolidinyl urea, 0.3% essence is to get receiving Rice hair nourishing liquid, and it is stored refrigerated in 4 DEG C.
A kind of nanometer hair nourishing liquid that treating alopecia seborrheica of embodiment 4
Preparation method：
(1) fleece-flower root 10g, angelica root 50g, ginseng 50g, cacumen biotae 10g, tea seed cake 3g and Chinese gall 15g is taken to throw respectively Enter in pulverizer, coarse crushing is at coarse powder；Medicinal material coarse powder is placed in extractor, the water of 8 times of weight is added, impregnates 30min, is decocted Extraction 2 times, each 30min；Merge decoction liquor twice, filtering, merging filtrate concentrates, alcohol precipitation, stands for 24 hours, revolving recycling second Alcohol obtains medicinal material medicinal extract to no alcohol taste；
(2) obtained medicinal material medicinal extract is added to and is mixed by 5% glycerine, 6% lecithin and 81% water ultrasonic agitation In nanoemulsions, with deionized water constant volume, it is then added 0.4% Bis(hydroxymethyl)imidazolidinyl urea, 0.3% essence is to get receiving Rice hair nourishing liquid, and it is stored refrigerated in 4 DEG C.
A kind of nanometer hair nourishing liquid that treating alopecia seborrheica of embodiment 5
Preparation method：
(1) fleece-flower root 50g, angelica root 10g, ginseng 10g, cacumen biotae 50g, 15 g of tea seed cake and Chinese gall 3g is taken to throw respectively Enter in pulverizer, coarse crushing is at coarse powder；Medicinal material coarse powder is placed in extractor, the water of 8 times of weight is added, impregnates 30min, is decocted Extraction 2 times, each 30min；Merge decoction liquor twice, filtering, merging filtrate concentrates, alcohol precipitation, stands for 24 hours, revolving recycling second Alcohol obtains medicinal material medicinal extract to no alcohol taste；
(2) obtained medicinal material medicinal extract is added to and is mixed by 5% glycerine, 6% lecithin and 81% water ultrasonic agitation In nanoemulsions, with deionized water constant volume, it is then added 0.4% Bis(hydroxymethyl)imidazolidinyl urea, 0.3% essence is to get receiving Rice hair nourishing liquid, and it is stored refrigerated in 4 DEG C.
Influence experiment of the 6 nanometers of hair nourishing liquids of embodiment to the new piliation in mouse alopecia of chemical origin area
1, experimental method
(1) it is grouped
66 kunming mices are numbered by weight, 20 groups of experimental groups and 1 group of blank control are divided into using random digits table Group, every group of 3 mouse.
The specific bulk pharmaceutical chemicals grouping situation of each experimental group is as follows：0, blank control group；1, the fleece-flower root；2, angelica root；3, people Join root；4, cacumen biotae；5, tea seed cake；6, Chinese gall；7, the fleece-flower root/angelica root；8, the fleece-flower root/ginseng；9, the fleece-flower root/arbor-vitae Leaf；10, the fleece-flower root/tea seed cake；11, the fleece-flower root/Chinese gall；12, the fleece-flower root/cacumen biotae/ginseng；13, the fleece-flower root/cacumen biotae/ Angelica root；14, the fleece-flower root/cacumen biotae/tea seed cake；15, the fleece-flower root/cacumen biotae/Chinese gall；16, the fleece-flower root/cacumen biotae/Radix Angelicae Sinensis Root/ginseng；17, the fleece-flower root/cacumen biotae/angelica root/tea seed cake；18, the fleece-flower root/cacumen biotae/angelica root/Chinese gall；19, He Shou Crow/cacumen biotae/angelica root/ginseng/tea seed cake；20, the fleece-flower root/cacumen biotae/angelica root/ginseng/Chinese gall；21, the fleece-flower root/ Cacumen biotae/angelica root/ginseng/tea seed cake/Chinese gall.The method of reference implementation example 1 is prepared into a nanometer hair nourishing liquid.
(2) it is administered
Mouse back depilation is applied to using vulcanized sodium, induction hair is long-term into life, and blank group is not appointed in addition to depilation Where is managed, and experimental group smears the nanometer hair nourishing liquid of above-mentioned each experimental group, applies medication 2 times outside daily, and each 0.2mL/ only, continuously gives Medicine 20 days.
(3) it scores mouse hair removal section body hair growth
It tests the 1st day, loses hair or feathers to mouse, after back wool is cut short, by the Na of depilatory agent 40%2S is applied to mouse back After about 2~3min, with warm water cleaning, with mouse back it is smooth without wound be net without residual hair, lose hair or feathers 4 × 4cm of area2.Respectively at de- Mao Hou gives a mark to newborn hair growth situation in 21 days, and standards of grading are：Hairless to be grown to 0 point, shallow staple length expires hair removal section It is 1 point, the half of newborn sweater degree and density about non-hair removal section is 2 points, and newborn staple length is 3 points with non-hair removal section indifference, The mouse for irregular hair growth occur is calculated by area ratio, is calculated every group of mean scores and is made curve.
(4) to the influence of mouse hair removal section chaeta length and weight
It tests the 21st day and each group mouse is taken off into neck execution, hair removal section fur is cut, in every mouse hair removal section same position The round skin graft of 1 a diameter of 25mm is taken, and takes and most becomes mildewed 3 in same position, vernier caliper measurement length is used under magnifying glass, The staple length that every mouse is represented with 3 Mao Junchang finds out each group mouse staple length mean value.All chaetas on skin graft are scraped with scalpel, It weighs, finds out the mean value of each group mouse gross weight.
2, experimental result
Each group mouse alopecia of chemical origin area new life hair length peace counterpoise scale after 2 medication of table 20 days
As shown in table 2 and Fig. 2, compared with blank group, after hair nourishing liquid 20 days, the alopecia area natural on-off cycles of hair growth of each experimental group There is obvious raising with weight；Wherein the fleece-flower root, angelica root, ginseng, cacumen biotae, tea seed cake and Chinese gall share (group 21) Effect it is best, 31.2% and 75.1% has been respectively increased in alopecia area new life hair length and average weight.And by data It is found that the hair regrowth of the fleece-flower root (group 1) is best when being used alone, compared with group 1, organizes 21 hair-growing effects and obtained significantly It is promoted, 24.7% and 52.5% has been respectively increased with weight in alopecia area natural on-off cycles of hair growth.This is because the fleece-flower root has anti-aging, crow Silk hair, happy color, the effect of strengthening the essence blood-nourishing can promote hair cell newborn；In addition to this, it is rich in the hairs life such as iron, zinc, violent Trace element necessary to long, also contains suitable lecithin, can promote new life and the development of cell；Have simultaneously plus cacumen biotae There are the effect of cooling blood and hemostasis, growing and blacking hair, ginseng to reinforce vital energy, veins takes off admittedly reinforces the spleen to benefit the lung, and promotes the production of body fluid, tranquilizing the mind effect, and five The convergence of gall nut, antibacterial, removing toxic substances effect, be aided in tea seed cake containing ingredients such as Tea Saponin, protein, natural tea oil, for a long time Using have only bits, it is antipruritic, deoil, sterilize, repair the effect of damaged hair, apparent synergistic work can be played after compounding With.
Influence experiment of the 7 different material content of embodiment to the new piliation in mouse alopecia of chemical origin area
1, based on embodiment 1, using different material content as variable, a series of products are prepared.To obtained product into Row product property is tested, and method is the same as embodiment 6.
2, the results are shown in Table 3.
Influence experiment of the 3 different material content of table to the new piliation in mouse alopecia of chemical origin area
Influence experiment of the different hair growth liquors of embodiment 8 to the new piliation in mouse alopecia of chemical origin area
1, experimental method
Separately 12 kunming mices is taken to be numbered by weight, is divided into using random digits table：Commonly educating without nanoemulsions Lotion group (based on embodiment 1, the common hair nourishing liquid without nanoemulsions is prepared), the nanometer hair nourishing liquid containing nanoemulsions 4 groups of group (nanometer hair nourishing liquid made from embodiment 1), positive controls (ZHANGGUANG 101) and blank control group, every group of 3 mouse, Property test is carried out, method is the same as embodiment 6.
2, result is as shown in Fig. 3, Fig. 4 and Fig. 5.By the experimental result in Fig. 3, Fig. 4 and Fig. 5 it is found that using hair nourishing liquid 20 After it, compared with common hair nourishing liquid group, positive controls (ZHANGGUANG 101) and blank control group without nanoemulsions, the present invention Nanometer hair nourishing liquid alopecia area natural on-off cycles of hair growth and weight be all significantly increased, the nanometer hair nourishing liquid containing nanoemulsions is shown Apparent synergistic function has apparent inhibition trichomadesis, trichogenous effect, can increase new piliation Weight and length, from the root cause improve hair ecology, effectively treat alopecia seborrheica.
Influence research of the embodiment 9 to human hair
The diameter of hair of usual people can reflect growth situation.It is " fine " that diameter, which is less than 60 μm,；60~80 μm are " medium hair "；It is then more than 80 μm " thick hair ".By being found to the follow-up study for largely taking off originator, most of patient is occurring greatly Before amount or apparent alopecia symptom, occur hair jewelry, expensive clothing and other valuables first, sparse or part falls off on a small quantity, wherein important index is exactly The diameter of hair, especially root of hair diameter taper into, that is to say, that hair is gradually soft.Whether can have by hair diameter bright It is aobvious to increase, judge nourishes effect of the liquid to hair follicle and hair indirectly.
1, the influence of nanometer hair nourishing liquid prepared by embodiment 1 to human hair
(1) study subject：Reference《Chinese medical disease Standardization of diagnosis and curative effect》To formulate following standard：1. hair sparse is even bald Top；2. though hair without apparent sparse, fall off apparent, feels that hair significantly reduces earlier above in the recent period；3. in the recent period not with alopecia phase The other diseases of pass；4. hair bits increase；5. hair is shinny, scalp grease is apparent；6. itching of the scalp.
Select 240 alopecia seborrheica patients for meeting above-mentioned standard, the age is 30~60 years old, wherein male 120, Women 120.240 patients are divided into two big groups of A, B, wherein：A group hair average diameters are 50 μm, and B group hairs are average straight Diameter is 40 μm.A, the groups greatly of B two are respectively divided into 3 groups respectively again, wherein：A1 groups are the age in 30~40 years old men and women each 20 People, A2 groups are men and women each 20 people of the age at 41~50 years old, and A3 groups are men and women each 20 people of the age at 51~60 years old；B1 groups are year Men and women each 20 people of the age at 30~40 years old, B2 groups are men and women each 20 people of the age at 41~50 years old, and B3 groups are the age 51~60 Each 20 people of men and women in year.
(2) experimental method：It is treated using the nanometer hair nourishing liquid prepared in embodiment 1.
The nanometer hair nourishing liquid of appropriate embodiment 1 is taken to be applied to scalp at alopecia according to hair loss conditions, twice daily.Uniformly choose It is measured using 50 forward and backward, each position hair of subject's head, to be demarcated as this root away from hair diameter at 1cm at root of hair The diameter of hair takes its average, is demarcated as subject's hair diameter, and obtained result is as shown in the following table 4,5.
The using effect of 4 A groups of table (50 μm of groups) subject
The using effect of 5 B groups of table (40 μm of groups) subject
From result above it is found that after the nanometer hair nourishing liquid using the present invention, hair average diameter has significantly Increase, after continuous use 9 months, based on the hair average diameter before being not used, hair diameter increases 52%~85%, this Hair follicle can be nourished by demonstrating the nanometer hair nourishing liquid of the present invention, keep hair sturdy, dense, effectively played Anti-hair loss, promoted hair Regenerated effect.
2, the shadow of nanometer hair nourishing liquid prepared by embodiment 2~5 and the comparative example 1~5 involved in embodiment 7 to human hair It rings
Optionally hair average diameter is 40 μm, man, female each 90 people of the age at 41~50 years old, using embodiment 2~5 and on The nanometer hair nourishing liquid that is prepared in comparative example 1~5 is stated to be treated.
Nanometer hair nourishing liquid prepared by equivalent embodiment 2~5 and above-mentioned comparative example 1~5 is taken to be applied to scalp at alopecia respectively, often It is twice.It uniformly chooses and is measured using 50 forward and backward, each position hair of subject's head, with away from head at 1cm at root of hair The diameter that diameter calibration is this root hair is sent out, its average is taken, is demarcated as subject's hair diameter, obtained result such as the following table 6 It is shown.
The using effect of 6 embodiment 2~5 of table and comparative example 1~5
By the experimental result in table 5 it is found that other nanometer hair nourishing liquids through using embodiment 2~5, hair average diameter are equal Have and significantly increase, after continuous use 9 months, compared with the hair average diameter before being not used, hair average diameter is equal There is different degrees of increase, this demonstrate that the herb composition of the present invention can nourish hair follicle, consolidate hair root, inhibits hair de- It falls, keeps hair sturdy, dense, the effect for effectively playing Anti-hair loss, promoting hair regeneration.
In addition, investigated for testing the subject in 1,2 above, 100% subject in use, alopecia The head of district goes out new hair, hair itch and greasy disappearance, and daily alopecia amount is reduced.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment Limitation, it is other it is any without departing from the spirit and principles of the present invention made by changes, modifications, substitutions, combinations, simplifications, Equivalent substitute mode is should be, is included within the scope of the present invention.

Claims (10)

1. a kind of herb composition for treating alopecia seborrheica, which is characterized in that include the component of following parts by weight：The fleece-flower root 10~50 parts, 10~50 parts of angelica root, 10~50 parts of ginseng, 10~50 parts of cacumen biotae, 1~15 part of tea seed cake, Chinese gall 1~15 Part.
2. the herb composition for the treatment of alopecia seborrheica according to claim 1, which is characterized in that including following parts by weight Several components：20~40 parts of the fleece-flower root, 20~40 parts of angelica root, 10~30 parts of ginseng, 20~40 parts of cacumen biotae, tea seed cake 5~ 12 parts, 5~12 parts of Chinese gall.
3. the herb composition for the treatment of alopecia seborrheica according to claim 1, which is characterized in that including following parts by weight Several components：30 parts of the fleece-flower root, 30 parts of angelica root, 20 parts of ginseng, 30 parts of cacumen biotae, 10 parts of tea seed cake, 10 parts of Chinese gall.
4. the herb composition for the treatment of alopecia seborrheica according to claim 1, which is characterized in that further include nano-emulsion Liquid；The grain size of the nanoemulsions is not more than 200 nm.
5. the herb composition for the treatment of alopecia seborrheica according to claim 4, which is characterized in that by weight percentage Meter, the nanoemulsions include：Emulsifier 2~10%, moisturizer 3~7%, preservative 0.4~0.5%, deodorant tune 0.3~0.5%, Surplus is deionized water.
6. the herb composition for the treatment of alopecia seborrheica according to claim 4, which is characterized in that the emulsifier is Lecithin, polysorbas20 or vitamin E polyethylene glycol succinic acid ester；The moisturizer is glycerine, mineral oil or sodium hyaluronate；It is described Preservative be bi-imidazolidinyl urea, Phenoxyethanol or tea tree ethereal oil class preservative；The deodorant tune is essence.
7. a kind of nanometer hair nourishing liquid for treating alopecia seborrheica, which is characterized in that be prepared by method comprising the following steps It arrives：
S1. with Extraction solvent to the fleece-flower root described in claim 1, angelica root, ginseng, cacumen biotae, tea seed cake and Chinese gall into Row extraction, obtains drug extract；
S2. by obtained drug extract with the emulsifier described in claim 4, nano-emulsion made of moisturizer and water Liquid phase mixes, and the preservative and deodorant tune is added to get nanometer hair nourishing liquid.
8. the nanometer hair nourishing liquid for the treatment of alopecia seborrheica according to claim 7, which is characterized in that by including following step Rapid method is prepared：
S1. after the fleece-flower root, angelica root, ginseng, cacumen biotae, tea seed cake and Chinese gall being crushed according to different weight ratio, The water of 7~9 times of amounts is added, after impregnating 20~40 min, 80~100 DEG C decoct extraction 2 times, and each 30min obtains drug extraction Liquid；Drug extract is merged, is concentrated, alcohol precipitation, 12~36 h are stood, recycling ethyl alcohol obtains medicinal material medicinal extract to no alcohol taste；
S2. obtained medicinal material medicinal extract is mixed with the nanoemulsions made of the emulsifier, moisturizer and water, is added Enter the preservative and deodorant tune to get nanometer hair nourishing liquid.
9. any any nanometer hair nourishing liquid of the herb composition or claim 7~8 of claim 1~6 is being made Application in the standby product for promoting hair growth and/or inhibiting alopecia.
10. application according to claim 9, which is characterized in that the product includes hair cream, shampoo, hair dye, shield Hair element or hair-nourishing liquid.
CN201810614411.8A 2018-06-14 2018-06-14 A kind of herb composition that treating alopecia seborrheica and nanometer hair nourishing liquid Withdrawn CN108743729A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109498537A (en) * 2018-12-26 2019-03-22 广州蜜妆生物科技有限公司 A kind of anti-shed hair growth liquid and preparation method thereof
CN111000778A (en) * 2019-11-23 2020-04-14 广东天仁科技有限公司 Hair loss preventing and hair growing liquid and preparation method thereof
CN111449998A (en) * 2020-03-25 2020-07-28 广西冠硕科技有限公司 Planting extract anti-hair loss hair-growing liquid and preparation method thereof
CN112315855A (en) * 2020-11-26 2021-02-05 广州环亚化妆品科技有限公司 Anti-hair loss and hair-nourishing composition and preparation method and application thereof
CN112773748A (en) * 2021-03-11 2021-05-11 广州文晖医药科技有限公司 Traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109498537A (en) * 2018-12-26 2019-03-22 广州蜜妆生物科技有限公司 A kind of anti-shed hair growth liquid and preparation method thereof
CN111000778A (en) * 2019-11-23 2020-04-14 广东天仁科技有限公司 Hair loss preventing and hair growing liquid and preparation method thereof
CN111449998A (en) * 2020-03-25 2020-07-28 广西冠硕科技有限公司 Planting extract anti-hair loss hair-growing liquid and preparation method thereof
CN111449998B (en) * 2020-03-25 2023-09-08 广西冠硕科技有限公司 Plant extract hair loss preventing hair growth liquid and preparation method thereof
CN112315855A (en) * 2020-11-26 2021-02-05 广州环亚化妆品科技有限公司 Anti-hair loss and hair-nourishing composition and preparation method and application thereof
CN112773748A (en) * 2021-03-11 2021-05-11 广州文晖医药科技有限公司 Traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof

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