CN110302129A - One kind educating hair anticreep scalp nursing solution - Google Patents
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Abstract
The present invention relates to one kind to educate hair anticreep scalp nursing solution.The scalp nursing solution includes following component in terms of the parts by weight of composition: 0.5-17 parts of Chinese medicine microorganism bi-directional fermentation concentrate, 70-96.3 parts of Chinese medicine extract, 1.5-5 parts of glycerol, 1.5-5 parts of propylene glycol, 0.2-3 parts of panthenol.The Chinese medicine microorganism bi-directional fermentation concentrate is that lucidum strain is carried out with ginseng, Roots of Panax Notoginseng and Radix Angelicae Sinensis to liquid bidirectional fermentation gained respectively.The Chinese medicine extract is by suitable Black Ganoderma, bignose rhinacanthus branchlet and leaf, and race, santal and cacumen biotae are through alcohol water extraction gained.The present invention utilizes Chinese medicine two-way fermentation technology, decomposes the cell wall of drug in prescription, promotes effective component release, meanwhile, macromolecular can be resolved into small molecule by the various enzymes that microbial metabolism generates, and remove big molecular impurity, and enhancing drug effect reduces toxic side effect.Scalp nursing solution produced by the present invention can promote scalp blood circulation, shine hair follicle vigor, achieve the purpose that educate hair anticreep.
Description
Technical field
The present invention relates to a kind of scalp nursing solutions.
Background technique
Alopecia is always the puzzlement of numerous consumers.In recent years, alopecia is even more to have the tendency that rejuvenation is presented.According to
Ali's health combines " rescue alopecia entertaining white paper " display of Ali's data publication, purchase hair transplant in 2017, hair products
It is after 90s that the after 80s of 38.5% accounting will be caught up with and surpassed with 36.1% accounting in consumer, become the main force for having alopecia.
According to relevant document, the reason of tracing alopecia is we have found that mainly there is following 5 aspects: (a) male sex hormone has
The hair follicle underactivity of pass.Head hair is influenced by male sex hormone, the stosterone of male sex hormone, at hair follicle also through 5 α-
Protoenzyme catalysis becomes the higher 5 α-dihydrotestosterone (DHT) of activity, and this variation is irreversible.DHT causes alopecia
Main cause, it can be transferred in nucleus in conjunction with intracellular receptor protein, by specific gene activation, induction life
At specific protein, to hinder the growth of hair, and then permanent alopecia or baldness are generated.(b) hair follicle, ball top portion
And hair physiological function is low.Hair be grown from hair follicle bottom, and on the papilla of hair follicle bottom there are many divide cell,
They are ball tops, and ball top is the originator of hair, have chromatophore in the episphere of ball top, their common effects are secretions
Grease moistens hair.It when fat secretion surplus, then will lead to generation alopecia seborrheica, or cause bacterium to generate chaff
Baldness.(c) local blood circulation obstacle caused by scalp is nervous, cause hair follicle, papilla tip capillary flow
It reduces, the food materials of papilla and hair matricyte are insufficient, the growth of hair occur abnormal.(d) malnutritive, stress
Reaction and drug side-effect.(e) inherent cause.
The method of hair growth has topical minoxidil lotion or oral Finasteride etc. at present, but minoxidil is correct
Skin has certain irritation, and main adverse reaction is hirsutism, and there are certain side effects;Finasteride have heredity and
Genotoxicity, risk are larger.And traditionally, people tackle the mode of alopecia, are usually used based on civil folk prescription, using put on the skin,
The form of therapy such as deposited, food, due to lacking systematic research and verifying, in addition individual difference alienation is big, effect is not generally good enough.Therefore,
Research and develop Chinese prescription, it is the trend of industry development that the educating of safety and Small side effects, which sends out product-stripping mechanism anti-,.
Patent CN109010182A discloses a kind of with jackfruit peel, ganoderma lucidum, the extracting solutions such as ginseng and zinc compound group
The Anti-hair loss composition of conjunction.The composition can effectively inhibit 5α-reductase activity in hair follicle cell, reduce testosterone to dihydro-testosterone
The conversion of ketone reduces the expression of transforming factor in hair follicle cell, delays hair follicle cell to enter stand-down, to reach Anti-hair loss
Purpose.Patent CN102038626B discloses a kind of Chinese medicine hair anti-drop liquid shampoo and preparation method thereof, to the hair washing prepared
Chinese medicine extract is added in water, is mixed evenly and obtains.Its Chinese medicine extract is with rhizoma zingiberis, pericarpium zanthoxyli, Rhizoma Chuanxiong, safflower, Radix Angelicae Sinensis
Deng for main effect ingredient, obtained by way of heating extraction.Patent CN108186800A discloses a kind of big with America
Lian, Noni fruit are the hair tonic of core functional component, black hair composition.Patent CN108434240A disclose it is a kind of with cacumen biotae,
Radix Angelicae Sinensis, safflower etc. are the treatment alopecia areata of main bulk pharmaceutical chemicals and the Chinese medicine composition of seborrhea.The composition directly uses ethyl alcohol
The active constituent of each bulk pharmaceutical chemicals is extracted, preparation process is simple, quick.Patent CN108553382A is disclosed one kind and is mentioned with kuh-seng
Take object, Notogineng Extract, Folium Artemisiae Argyi extract, the anticreep scalp nursing solution as main component such as Cacumen Platycladi extract.
The educating of current published patent or the Chinese prescription listed send out product-stripping mechanism anti-there are certain shortcomings:
(a) prescription is concerned only with a certain link in alopecia reason, not to the complete because being intervened and being adjusted of alopecia;(b) it discloses specially
Benefit or listing external application educate that send out anti-product-stripping mechanism majority be common alcohol extract or alcohol water extract, and the effective component of critical medication fails most
Limits release.
Accordingly, it is desirable to provide one kind overcomes above-mentioned deficiency, and it is effective to the alopecia of different reasons, it is true to educate hair anticreep effect
It cuts, type scalp nursing solution the effect of safety and Small side effects.
Summary of the invention
The object of the present invention is to provide one kind to educate hair anticreep scalp nursing solution.
It is a further object to provide a kind of preparation methods for educating hair anticreep scalp nursing solution.
One kind of the invention educates hair anticreep scalp nursing solution, includes following component: 0.5- in terms of the parts by weight of composition
17 parts of Chinese medicine microorganism bi-directional fermentation concentrate, 70-96.3 parts of Chinese medicine extract, 1.5-5 parts of glycerol, 1.5-5 parts
Propylene glycol, 0.2-3 parts of panthenol.
Chinese medicine microorganism bi-directional fermentation concentrate used in the present invention be by lucidum strain respectively with ginseng, Roots of Panax Notoginseng
After carrying out liquid bidirectional Fermented Condensed with Radix Angelicae Sinensis, it is mixed to prepare by weight 10-30:20-40:15-30.Lucidum strain (strain
Number 5.0026) commercially available acquisition, it is purchased from China General Microbiological culture presevation administrative center.
Chinese medicine extract used in the present invention is made after the extraction of alcohol water by the Chinese medicine of following parts by weight: 20-40 portions of ginger
Root, 10-30 portions of cacumen biotaes, 5-20 parts of Black Ganodermas, 5-20 parts of bignose rhinacanthus branchlet and leafs, 3-10 portions of santals and 2-20 times of parts by weight of the above ingredient
Alcohol water.
Alcohol water used in the present invention is mixed to prepare by ethyl alcohol and thermal water with the volume ratio of 10-75:25-90.
Thermal water used in the present invention is selected from one kind of underground thermal water.The pH value of the thermal water is between 5.5-7.5
Between, Features of Hydrochemistry leading ion SO4 2-Content is not less than 100mg/L.
The preparation method of scalp nursing solution of the invention includes the following steps.
(I) weighing 200g potato, cleans, removes the peel, is cut into small pieces, and adds suitable quantity of water to decoct 15min or so, by Ma Ling
Potato potato wedge boil it is thoroughly well cooked but not mushy, filter (6 layers of gauze), take filtered juice.Glucose 20.00g, KH are weighed respectively2PO4 1.50g、
MgSO4 1.00g, 1 VB 0.05g, agar powder 25.00g add a small amount of distilled water in beaker, and small fire dissolves by heating, with
The mixing of potato filtered juice, is settled to 1000mL, stirs evenly, be sub-packed in test tube, cover tightly silica gel plug, be uprightly put into sterilizing
(0.1MPa, 30min) is sterilized in pot.It is taken out after sterilizing, is put into inclined-plane in desinfection chamber, it is spare after cooled and solidified.Aseptic inoculation
When, lucidum strain is accessed into slant medium middle position rapidly, sets in 26 DEG C of constant incubators and cultivates 6d, therefrom select bacterium
White dense, the sturdy and neat in edge of silk, pollution-free, it is spare that the vigorous strain of growing way is put into 4 DEG C of refrigerators.
(II) respectively by ginseng, Radix Angelicae Sinensis, Radix Notoginseng crushes through medicinal herb grinder, crosses 10 meshes.Ginseng pulverate is accurately weighed, when
Distilled water is added by weight 1: 10 respectively in Gui Fen, appropriate Radix Notoginseng powder, and ultrasonic 20min is sub-packed in 250mL triangular flask,
Sealing, 121 DEG C of sterilizing 20min, cooling are spare.Strain after taking appropriate activation is seeded to liquid fermentation medium respectively
In, in 28 DEG C, shaking table shaken cultivation 19d, 15d, 17d under the conditions of 150r/min.Tunning is sent out respectively through filtering
Zymotic fluid and mycelium, fermentation liquid is concentrated under reduced pressure, and is mixed by weight 3:4:3, and the concentration of Chinese medicine microorganism bi-directional fermentation is obtained
Liquid.
(III) 10-30 portions of cacumen biotaes are taken, 5-20 parts of Black Ganodermas, 5-20 parts of bignose rhinacanthus branchlet and leafs crush after 3-10 parts of santal drying,
It is uniformly mixed, 20-40 parts of races is added, the alcohol water (volume ratio of ethyl alcohol and thermal water are as follows: 10- of 1-10 times of weight is then added
75:25-90), 30min is kept after boiling, and is filtered, is obtained the first filtrate and filter residue, filter residue adds the alcohol water of 1-10 times of weight
(volume ratio of ethyl alcohol and thermal water are as follows: 10-75:25-90), keeps 30min after boiling, after filtering the second filtrate, merge the
One filtrate and the second filtrate, obtain Chinese medicine extract.
It (IV) will be in the Chinese medicine microorganism bi-directional fermentation concentrate of 0.5-17 part of weight percent meter, 70-96.3 parts
Medicament extracting solution, 1.5-5 parts of glycerol, 1.5-5 parts of propylene glycol, 0.2-3 parts of panthenol are uniformly mixed, and obtain the scalp care
Liquid.
By above-mentioned technical proposal, the present invention is had the following obvious advantages.
The invention carries out prescription from multiple alopecia inducements, reaches and preferably educates hair anticreep effect.Firstly, according to Chinese medicine alopecia
" speen-kidney dificiency, kidney deficiency and liver " is theoretical, and formula uses ginseng reinforcing spleen and kidney, and Roots of Panax Notoginseng promoting blood circulation promotees circulation, and Chinese angelica blood supplementing promotes the production of body fluid,
Black Ganoderma tonifying liver QI invigorating improves immunity;Secondly, modern medicine study is shown, alopecia is many factors such as inherent cause, answers
Swash, the synergistic effects such as the autoimmunity in immune system and allergy, skin barrier, bacterium, pathogenic infection as a result,
After inflammatory factor including scalp microenvironment especially inflammatory factor reaches certain threshold value, cause the hair follicle degenerative disease in region
Become.Race strengthening the spleen and stomach is used in formula, while there is activation hair follicle, inhibiting bacteria and diminishing inflammation effect;Rhinacanthus nasuta Kurz heat-clearing is soothing the liver, dampness removing
It is antipruritic;Cacumen biotae is anti-inflammatory and promotes blood circulation, activation decline hair follicle;Thermal water expands blood vessel, aoxidizes pathological product, promotes scorching
Disease disappears.Santal extracting solution in formula can the expression of hair follicle stimulating olfactory receptor rise, postpone the hair follicle regresses phase.
Using Chinese medicine bi-directional fermentation technique, increase the utilization rate of effective ingredient, reduces the toxic side effect of drug.Because
The plant cell of Chinese medicine has the cell wall of compact structure, the release of the effective component in cell cytosol has been obstructed, in
In medicine bi-directional fermentation technology, microorganism can generate a variety of ectoenzymes such as cellulase, pectase in the metabolic process, they can be with
The cell wall for decomposing plant cell, makes Chinese medicine cell rupture, effective component is allowed to be exposed, and effective component is promoted to release
It puts, enhances drug effect.In addition, the molecular weight of effective component of chinese medicine is generally bigger, it is not easy across skin barrier, to a certain extent
The performance of drug effect is prevented, and the various enzymes generated during Chinese medicine bi-directional fermentation can reduce the molecular weight of effective ingredient,
A variety of big molecular impurities are eliminated simultaneously, play the role of " attenuation synergistic ".
Each component effect is as follows in this prescription.
Black Ganoderma: Black Ganoderma is warm-natured, lightly seasoned.Polysaccharide is one of the main active in Black Ganoderma extract.Modern times doctor
Improve body's immunity, antitumor, elimination machine interior free yl, anti-spoke experiments have shown that ganoderma lucidum polysaccharide activity extensively, has
It penetrates, improve the effects of liver detoxification function.
Bignose rhinacanthus branchlet and leaf: cool in nature sweet in flavor, master enters lung, liver, stomach, all warps of intestine and small intestine, has moistening lung to arrest cough, eliminating the phlegm of relievining asthma, heat-clearing
Soothing the liver, removing dampness through diuresis and relieving itching, astringing to arrest bleeding and other effects.
Race: nature and flavor are pungent, tepor.Function expelling wind and activating blood flow promotes scalp blood circulation, produces and prevent hair loss, and inhibits head
Skin itch.
Ginseng: nature and flavor are sweet, slight bitter, warm-natured, flat.Returns spleen, lung channel, the heart channel of Hang-Shaoyin.Scalp capillary can be expanded, scalp is promoted
Blood circulation, increases scalp nutrition supply, tonifying Qi, and prevent prolapse is promoted the production of body fluid.
Roots of Panax Notoginseng: nature and flavor are sweet, slight bitter, warm-natured.Enter liver, stomach, large intestine channel.Radix Notoginseng function is enriched blood, stasis eliminatings damage, hemostasis nosebleed, energy
It is logical to mend.Its effective component has based on saponins and dencichine and stops blooding, invigorates blood circulation, enriching blood, antithrombotic, protect cardiac muscle, is anti-inflammatory
Etc. multiple efficacies.
Santal: acrid flavour, it is warm-natured, it is nontoxic.Enter spleen, stomach, lung channel.Santal extracting solution can extend hair follicle be in early growth period when
Between, postpone the arrival of catagen.Its mechanism is the expression rising that santal extracting solution promotes hair follicle olfactory receptor OR2AT4, is improved
The expression of some growth factors in external root sheath prevents hair follicle regresses to promote the extension of hair follicle growth phase.In addition, sandalwood oil
Also there is very strong bactericidal effect, the growth of propionibacterium acnes, dermatophyte can be inhibited, inhibit HSV isolation type multiple
System, and host cell acellular poison is acted on, the update of cell is stimulated, spot, wound, acne and other skins are facilitated
The healing of disease.
Cacumen biotae: nature and flavor are bitter, slightly cold channel tropism.Main component is volatile oil, flavone compound and tannin, is had
Antibacterial, antitumor, anti-inflammatory, anti-erythrocyte oxidation, hemostasis, debris removing anticreep and the effect that beard and hair can be given birth to.The pharmacology of its Anti-hair loss is made
With essentially consisting in activation hair follicle cell and promoting blood circulation, the hair follicle for making hair growth ability fail brings back to life and blood is promoted to follow
The effect of hair care, hair tonic is supplemented the nutrients and played after ring.
Radix Angelicae Sinensis: acrid-sweet flavor, temperature, Radix Angelicae Sinensis are referred to as " key medicine of enriching blood ", and polysaccharide is one of main active in Radix Angelicae Sinensis,
Hematopoiesis mechanism predominantly promotes hematopoietic cell proliferation and differentiation, stimulation hematopoieticmicroenviron-ment to discharge hemopoieticgrowth factor, to induce
The generation of hematopoietic cell.So scalp capillary can be expanded, promote blood circulation, strengthen the hair is promoted the production of body fluid, and hair is nourished.
Thermal water: the SO in thermal water4 2-S in ion can be dissociated partially, make peripheral vasodilation, aoxidize pathological product,
Inflammation is promoted to disappear;Furthermore the micro sulfur component in hot spring can form akali sulphide on the skin, and akali sulphide can soften angle
Matter layer, the state for improving disease damage skin, this mild stimulation improve dermovascular expansion and body in body surface receptor
Table blood circulation.
Specific embodiment
If the following table 1 is the nonlimiting examples 1-3 of scalp nursing solution of the invention, providing for these embodiments is only used to
Illustrate the present invention, but is not intended to limit the scope of the invention.
The composition (each component based on g) of scalp nursing solution embodiment 1-3 is shown in Table 1.
Table 1.
The activation of lucidum strain: weighing 200g potato is cleaned, removes the peel, is cut into small pieces, suitable quantity of water is added to decoct 15min
Left and right, potato potato wedge is boiled it is thoroughly well cooked but not mushy, filter (6 layers of gauze), take filtered juice.Weigh respectively glucose 20.00g,
KH2PO4 1.50g、MgSO4 1 0.05g of 1.00g, VB, agar powder 25.00g add a small amount of distilled water in beaker, and small
Fire dissolves by heating, and mixes with potato filtered juice, is settled to 1000mL, stir evenly, be sub-packed in test tube, covers tightly silica gel plug,
Uprightly it is put into sterilizing (0.1MPa, 30min) in autoclave.It is taken out after sterilizing, inclined-plane, cooled and solidified is put into desinfection chamber
It is spare afterwards.When aseptic inoculation, lucidum strain is accessed into slant medium middle position rapidly, sets in 26 DEG C of constant incubators and trains
6d is supported, therefrom selects that white mycelium is dense, and sturdy and neat in edge is pollution-free, the vigorous strain of growing way is put into 4 DEG C of refrigerators
It is spare.
Embodiment 1.
Ginseng pulverate 10g, Radix Notoginseng powder 20g, angelica powder 15g are accurately weighed, distilled water is added by weight 1: 10 respectively,
Ultrasonic 20min is sub-packed in 250mL triangular flask, sealing, 121 DEG C of sterilizing 20min, and cooling is spare.After taking appropriate activation
Lucidum strain be seeded in liquid fermentation medium respectively, in 28 DEG C, shaking table shaken cultivation 19d under the conditions of 150r/min,
15d, 17d.Tunning obtains fermentation liquid and mycelium respectively, fermentation liquid is concentrated under reduced pressure through filtering, and by weight 10:
20:15 mixing, obtains Chinese medicine microorganism bi-directional fermentation concentrate.
Bignose rhinacanthus branchlet and leaf 5g, race 20g, santal 3g are taken, crushes, is uniformly mixed after cacumen biotae 20g drying, be then added 10 times
The alcohol water (alcohol water ratio is 10:90, and water is thermal water) of parts by weight, keeps 30min, filters, obtain the first filtrate and filter after boiling
Slag, filter residue add the alcohol water of its 10 times of weight, and 30min is kept after boiling, and the second filtrate is obtained after filtering, merge the first filtrate
With the second filtrate, Chinese medicine extract is obtained.
The Chinese medicine microorganism bi-directional fermentation concentrate of 0.5g, 96.3g are extracted into concentrate, the glycerol of 1.5g, 1.5g
Propylene glycol, 0.2g panthenol be mixed to prepare uniformly mixed, obtain mixed liquor.
Embodiment 2.
Ginseng pulverate 25g, Radix Notoginseng powder 25g angelica powder 25g are accurately weighed, distilled water, ultrasound is not added by weight 1: 10
20min is sub-packed in 250mL triangular flask, sealing, 121 DEG C of sterilizing 20min, and cooling is spare.Spirit after taking appropriate activation
Sesame strain is seeded in liquid fermentation medium respectively, in 28 DEG C, shaking table shaken cultivation 19d, 15d under the conditions of 150r/min,
17d .Tunning obtains fermentation liquid and mycelium respectively, fermentation liquid is concentrated under reduced pressure through filtering, and by weight 20:30:
30 mixing, obtain Chinese medicine microorganism bi-directional fermentation concentrate.
Bignose rhinacanthus branchlet and leaf 15g, race 32g, santal 7g are taken, crushes, is uniformly mixed after cacumen biotae 20g drying, be then added 5 times
The alcohol water (alcohol water ratio is 40:60, and water is thermal water) of parts by weight, keeps 30min, filters, obtain the first filtrate and filter after boiling
Slag, filter residue add the alcohol water of its 2 times of weight, and 30min is kept after boiling, and the second filtrate is obtained after filtering, merge the first filtrate
With the second filtrate, Chinese medicine extract is obtained.
By the Chinese medicine microorganism bi-directional fermentation concentrate of 3g, extraction concentrate, the glycerol of 5g, the propylene glycol of 3g, 2g of 87g
Panthenol be mixed to prepare uniformly mixed, obtain mixed liquor.
Embodiment 3.
Ginseng pulverate 30g, Radix Notoginseng powder 40g, angelica powder 30g are accurately weighed, distilled water is added by weight 1: 10 respectively,
Ultrasonic 20min is sub-packed in 250mL triangular flask, sealing, 121 DEG C of sterilizing 20min, and cooling is spare.After taking appropriate activation
Lucidum strain be seeded in liquid fermentation medium respectively, in 28 DEG C, shaking table shaken cultivation 19d under the conditions of 150r/min,
15d, 17d.Tunning obtains fermentation liquid and mycelium respectively, fermentation liquid is concentrated under reduced pressure through filtering, and by weight 30:
25:30 mixing, obtains Chinese medicine microorganism bi-directional fermentation concentrate.
Bignose rhinacanthus branchlet and leaf 5g, race 20g, santal 3g are taken, crushes, is uniformly mixed after cacumen biotae 20g drying, be then added 1 times
The alcohol water (alcohol water ratio is 75:25, and water is thermal water) of weight, keeps 30min, filters, obtain the first filtrate and filter residue after boiling,
Filter residue adds the alcohol water of its 1 times of weight, and 30min is kept after boiling, and obtains the second filtrate after filtering, merges the first filtrate and the
Two filtrates, obtain Chinese medicine extract.
By the Chinese medicine microorganism bi-directional fermentation concentrate of 17g, 70g extract concentrate, the glycerol of 5g, 5g propylene glycol,
The panthenol of 3g is mixed to prepare uniformly mixed, obtains mixed liquor.
Using effect.
Choose 60 list stoves or more stove type alopecia areata volunteers and 60 hair sparses or even bald alopecia seborrheica aspiration
Person tries out the scalp nursing solution of 1-3 of the embodiment of the present invention.Wherein, 18 years old to 52 years old alopecia areata volunteer age, alopecia seborrheica will
At 30 years old to 56 years old hope person's age, male to female ratio is random.
Application method: smearing or is sprayed on scalp, is advisable so that scalp is wet, and with finger pulp appropriateness massaging scalp;Sooner or later daily
It is each primary, it is used continuously 30 days.
Curative effect determinate standard: recovery from illness: hair stopping falls off, and new hair is all grown, distribution density, thickness, color and strong
Send out Qu Xiangtong.Effective: hair stopping falls off, and new hair regeneration is up to 70% or more, and density, thickness and color are close to the area Jian Fa.
Effective: hair stopping falls off, and new hair regeneration is up to 30% or more, including fine hair on birds or animals hair and white hair are grown.Invalid: hair regeneration is less than 30%
Or continue to de- originator.Total effective rate: cure rate+obvious effective rate+effective percentage.
60 alopecia areata volunteers are randomly divided into 3 groups, and every group of 20 people, gender is random, try out the scalp shield of present example 1-3
Manage liquid.Using effect is shown in Table 2.
Table 2.
60 alopecia seborrheica volunteers are randomly divided into 3 groups, and every group of 20 people, gender is random, try out present example 1-3's
Scalp nursing solution.Using effect is shown in Table 3.
Table 3.
It therefore deduces that, one kind of the invention educates hair anticreep scalp nursing solution to single stove or more stove type alopecia areatas and seborrheica
Alopeciaing therapeutic significant effect, 120 volunteers on probation illustrate that product of the present invention is a safety without apparent adverse reaction,
And anticreep scalp nursing solution is sent out in curative for effect educating.
Although embodiment cited by the present invention is as above, the content only for ease of understanding the present invention and use reality
Mode is applied, not to limit the present invention.
Claims (5)
1. one kind educates hair anticreep scalp nursing solution, which includes following component: 0.5- in terms of the parts by weight of composition
17 parts of Chinese medicine microorganism bi-directional fermentation concentrate, 70-96.3 parts of Chinese medicine extract, 1.5-5 parts of glycerol, 1.5-5 parts
Propylene glycol, 0.2-3 parts of panthenol.
2. according to claim 1 educate hair anticreep scalp nursing solution, wherein the Chinese medicine microorganism bi-directional fermentation concentration
Liquid is after carrying out liquid bidirectional Fermented Condensed with ginseng, Roots of Panax Notoginseng and Radix Angelicae Sinensis respectively by lucidum strain, by weight 10-30:
20-40:15-30 is mixed to prepare.
3. according to claim 1 educate hair anticreep scalp nursing solution, wherein the Chinese medicine extract is by following parts by weight
Chinese medicine through alcohol water extraction after be made: 20-40 parts of races, 10-30 portions of cacumen biotaes, 5-20 parts of Black Ganodermas, 5-20 parts of bignose rhinacanthus branchlet and leafs,
The alcohol water of 3-10 portions of santals and 2-20 times of parts by weight of the above ingredient.
4. Chinese medicine extract according to claim 3, wherein the alcohol water is by ethyl alcohol and thermal water with 10-75:25-90
Volume ratio be mixed to prepare.
5. alcohol water according to claim 4, wherein the thermal water is selected from one kind of underground thermal water, it is characterized in that PH
Value is between 5.5-7.5, Features of Hydrochemistry leading ion SO4 2-Content is not less than 100mg/L.
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---|---|---|---|---|
CN111700841A (en) * | 2020-06-11 | 2020-09-25 | 梧州市华夏医药科技有限公司 | Hair loss preventing and hair growing shampoo containing ganoderma atrum plant extract essence and preparation method thereof |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103316058A (en) * | 2013-05-22 | 2013-09-25 | 甘肃农业大学 | Technology for improving drug effects of Mythic Fungus and Chinese angelica through utilizing Mythic Fungus-Chinese angelica bidirectional fermentation |
CN103911294A (en) * | 2014-03-11 | 2014-07-09 | 中国科学院长春应用化学研究所 | Liquid fermentation method of ginseng-radix astragali-lucid ganoderma medical mycoplasm |
CN104548011A (en) * | 2014-12-29 | 2015-04-29 | 余德常 | Hair generating and growing agent and production process thereof |
CN105193905A (en) * | 2014-06-27 | 2015-12-30 | 甘肃农业大学 | Traditional Chinese medicine processing technology of ganoderma-astragalus membranaceus bidirectional fermentation |
CN107157909A (en) * | 2017-06-29 | 2017-09-15 | 芜湖凌梦电子商务有限公司 | A kind of Hair-loss-preventingshampoo shampoo |
CN107184485A (en) * | 2017-07-06 | 2017-09-22 | 福建省海乐威生物工程有限公司 | A kind of jasmine hot spring face cream with repair |
CN107260627A (en) * | 2017-06-05 | 2017-10-20 | 江门市蓬江区海豚水族有限公司 | One kind educates nigrescence hair essence and preparation method thereof |
CN107510829A (en) * | 2017-07-31 | 2017-12-26 | 贵港市光速达电子科技有限公司 | A kind of external medicinal liquid for treating alopecia areata |
CN108815088A (en) * | 2018-09-18 | 2018-11-16 | 云南邦乐生物科技有限公司 | A kind of phalacrosis prevention and hair generation shampoo and preparation method thereof |
CN110123721A (en) * | 2019-06-17 | 2019-08-16 | 医美生物科技(上海)有限公司 | A kind of shampoo compositions improving oiliness scalp |
-
2019
- 2019-08-21 CN CN201910775037.4A patent/CN110302129A/en active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103316058A (en) * | 2013-05-22 | 2013-09-25 | 甘肃农业大学 | Technology for improving drug effects of Mythic Fungus and Chinese angelica through utilizing Mythic Fungus-Chinese angelica bidirectional fermentation |
CN103911294A (en) * | 2014-03-11 | 2014-07-09 | 中国科学院长春应用化学研究所 | Liquid fermentation method of ginseng-radix astragali-lucid ganoderma medical mycoplasm |
CN105193905A (en) * | 2014-06-27 | 2015-12-30 | 甘肃农业大学 | Traditional Chinese medicine processing technology of ganoderma-astragalus membranaceus bidirectional fermentation |
CN104548011A (en) * | 2014-12-29 | 2015-04-29 | 余德常 | Hair generating and growing agent and production process thereof |
CN107260627A (en) * | 2017-06-05 | 2017-10-20 | 江门市蓬江区海豚水族有限公司 | One kind educates nigrescence hair essence and preparation method thereof |
CN107157909A (en) * | 2017-06-29 | 2017-09-15 | 芜湖凌梦电子商务有限公司 | A kind of Hair-loss-preventingshampoo shampoo |
CN107184485A (en) * | 2017-07-06 | 2017-09-22 | 福建省海乐威生物工程有限公司 | A kind of jasmine hot spring face cream with repair |
CN107510829A (en) * | 2017-07-31 | 2017-12-26 | 贵港市光速达电子科技有限公司 | A kind of external medicinal liquid for treating alopecia areata |
CN108815088A (en) * | 2018-09-18 | 2018-11-16 | 云南邦乐生物科技有限公司 | A kind of phalacrosis prevention and hair generation shampoo and preparation method thereof |
CN110123721A (en) * | 2019-06-17 | 2019-08-16 | 医美生物科技(上海)有限公司 | A kind of shampoo compositions improving oiliness scalp |
Non-Patent Citations (1)
Title |
---|
锦辉等: "中药双向发酵技术在化妆品中的应用", 《日用化学工业》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111700841A (en) * | 2020-06-11 | 2020-09-25 | 梧州市华夏医药科技有限公司 | Hair loss preventing and hair growing shampoo containing ganoderma atrum plant extract essence and preparation method thereof |
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