CN104491181A - Traditional Chinese medicine composition for treating alopecia as well as preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating alopecia as well as preparation method and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating alopecia as well as a preparation method and an application of the traditional Chinese medicine composition, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 50-100 parts of Chinese angelica, 30-80 parts of mulberries, 10-60 parts of mulberry leaves, 20-70 parts of fruits of Chinese wolfberry, 45-95 parts of glossy privet fruits, 15-65 parts of rehmannia, 40-90 parts of astragalus, 70-120 parts of polygonum multiflorum (prepared), 25-75 parts of cacumen biotae, 45-95 parts of eclipta, 20-70 parts of ligusticum wallichii, 60-110 parts of black sesames, 35-85 parts of seeds of Chinese dodder, 55-105 parts of prepared rehmannia roots and 40-90 parts of spatholobus suberctu. According to the clinical observation test results, the traditional Chinese medicine composition disclosed by the invention has a remarkable curative effect on alopecia areata, alopecia totalis, alopecia universalis and other baldness types, is free of any adverse reaction. The traditional Chinese medicine composition disclosed by the invention is a safe and effective composition for treating alopecia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition and its preparation method and application of hair growth, belongs to the field of Chinese medicines.
Background technology
De-(bald) is sent out is whole world commonly encountered diseases, especially more outstanding in developing country.China's 20 ~ 50 years old people's alopecia prevalence is up to 20 ~ 30% to have data to show, the most conservative estimation also thinks that China's de-(bald) sends out patient and about has people more than 100,000,000, minimum 40,000,000 people in potential consumption market.Be the open epoch now, person to person contacts closely, and the image of individual is very important, so people start to pay attention to de-(bald) question topic.Therefore, the produce market demand space sent out of exploitation treatment de-(bald) is larger.Alopecia is clinical common trichopathy, though do not belong to serious disease, produces larger impact to the spirit of people, psychology.Along with growth in the living standard, people are day by day urgent to the requirement of cosmetology, and modern medicine and traditional medicine also more and more pay attention to the research to alopecia.
Alopecia comprises alopecia areata, seborrheic alopecia, androgen source property alopecia, psychogenic alopecia etc., belongs to Chinese medicine " alopecia areata ", " alopecia seborrheica " category.Hair loss patient is usually because some factor causes hair to enter the resting stage of hair growth too early by trophophase, hair follicle and ball top atrophy, become thin hair from terminal hair and cause (SpringerK, Brown M, Stulberg DL.Common hair loss disorders [J] .Am Fam Physician, 2003,68 (1): 93-102).Alopecia areata is more common in person between twenty and fifty, and men and women's sickness rate is substantially identical, and normal generation suddenly, many no conscious symptons, non-cicatrical, struvite circle or the alopecia of elliptical spot lamellar in limitation, not of uniform size, boundary is obvious.The hair development that patients with alopecia areata can see trophophase is in early days bad, perifollicolar CD
4 +t cell infiltrates.Can see hair follicle atrophy, hair and hair papilla late period to diminish, the non-full-shape of new setation, intradermal can see vasculitis and periangiitis, and vasoganglion density reduces.In recent years modern medicine is more to its research, and result of study shows, alopecia areata is the auto-immune related disease of a kind of T cell mediation, clinical manifestation is optimum, non-Cicatricial baldness, many no conscious symptons, can betide whole body any by hair position, severe patient can advance to alopecia totalis and alopecia universalis.The general knowledge of alopecia totalis: about have its alopecia of the case of 5% ~ 10% to carry out gradually or to develop rapidly in alopecia areata, in several days or some months, hair all comes off and forms alopecia totalis, What is more can involve eyebrow, beard, armpit hair, pubes etc. for the symptom of alopecia totalis, only a few severe patient whole body fine hair on birds or animals Mao Yike takes off light, and this is called alopecia universalis.It is relevant that the traditional Chinese medical science thinks that alopecia areata betides deficiency of the liver and kindey, essence and blood loss and wind Sheng heat in blood etc. more.Modern medicine is thought, primary disease is autoimmune disease, abnormal relevant with inherited genetic factors, Nervous and Mental Factors, immunologic function, endocrine, microcirculation and trace element etc.
Alopecia areata belongs to Chinese medicine " alopecia areata " category, and the traditional Chinese medical science is thought " hair is the sign of blood condition ", wind syndrome due to blood-deficiency, blood hot air wind producing or deficiency of both the liver and kidney be alopecia areata because of place, successive dynasties medical science is discussed from these aspects alopecia areata etiology and pathogenesis." Waike Zhengzong, Orthodox Manual of External Diseases " is recorded " alopecia areata is that blood deficiency can not support skin with gas honor, therefore hair root is empty, comes off in flakes ... this all heat in blood attack in an opponent's defence note and right "." surgery great achievement " is said: " alopecia areata is hair fall in flakes then, skin Lightening, and formicant itching person is also, attacks note in an opponent's defence by wind heat, and blood can not flourishly be supported caused "., claim alopecia areata to be " pore wind attacks blood of causing injury " in Golden Mirror of Medicine, the Sui Dynasty " General Treatise on the Cause and Symptoms of Diseases " is said: " people has ailment said due to cold or exposure at head; have partially empty place, then falling out, muscle is withered; or as large in money or as large in referred to; a not life, does not also itch, therefore licks head for ghost ", in addition also point out in this book " foot-shaoyang gallbladder through also; its honor at palpus, respecting work of kidney meridian, its Hua Fa.The arteries and veins that punching is appointed is the sea of blood of sea of the twelve channels, meaning, lip on its other network.If blood is contained, flourish in beard and hair, therefore beard and hair is beautiful; If vim and vigour are weak, exhaust through deficient pulse, can not Rong Run, therefore beard and hair alopecia ".
In addition, the generation of alopecia areata is also relevant with emotional factors.Theory of Chinese medical science think happiness then sad, anger then impairing the liver, think, the impairment of the spleen, compassion then impairing the lung, be probably then impairment of the kidney, disease caused by feelings will wound with the heart, liver, spleen three is dirty is many.The heart plays a leading role in the feelings will change of human body, grieved, can not push away the up nourishing hair of QI and blood, easily make hair dry up, come off.Melancholy impairing the spleen, taste are source of generating QI and blood.Depressed rage impairing the liver, blood stored in the liver and main catharsis, depression of liver-QI then loses in catharsis, and QI and blood can not continue flourishly to support hair, so that comes off.In addition sad lung, excessive fear impairing the kidney, can affect the growth promoter of hair equally, cause alopecia.
Alopecia areata is the common difficult miscellaneous diseases of department of dermatologry, day by day becomes the research emphasis of department of dermatologry in recent years, and achieves comparatively quantum jump.The understanding day of each doctor to primary disease is aligned, thinks that Chinese medicine has its advantageous advantage in treatment primary disease.Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is not only flexible and changeable, meets the demand of individuation, safe and effective, is suitable for long-term taking, can avoid the shortcoming of western medical treatment simultaneously.Traditional Chinese medical science treatment by oral administration of medicines method has given full play to the characteristic of traditional Chinese medical science organic conception and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, regulates body function to effect a permanent cure on the whole.Chinese medicine compound has the advantages such as determined curative effect, toxic and side effects are little, and under instruction of Chinese Medicine theory, from entirety, regulate the equilibrium between yin and yang of body, treating both the principal and secondary aspects of a disease, has obtained good clinical efficacy.Chinese medicine compound is screened, discloses its mechanism of action, develop safer, effective cmm of simple prescription and compound recipe has become main research direction.This product has nourishing the liver and kidney, and QI invigorating is supported flourish, and the function of active hair growth promoting, for baldness.Formula energy nourishing the liver and kidney of the present invention, by taking good care of whole body QI and blood Liver and kidney, fundamentally to its treatment, reaches therapeutic purposes, determined curative effect.
Summary of the invention
First object of the present invention is the Chinese medicine composition providing a kind of hair growth.
Second object of the present invention is to provide a kind of method preparing the tablet of above-mentioned Chinese medicine composition.
3rd object of the present invention is to provide above-mentioned Chinese medicine composition preparing the purposes in hair growth medicine.
Above-mentioned purpose of the present invention is achieved by the following technical solution:
A Chinese medicine composition for hair growth, is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 50-100 part, Fructus Mori 30-80 part, Folium Mori 10-60 part, Fructus Lycii 20-70 part, Fructus Ligustri Lucidi 45-95 part, Radix Rehmanniae 15-65 part, Radix Astragali 40-90 part, Radix Polygoni Multiflori (system) 70-120 part, Cacumen Platycladi 25-75 part, Herba Ecliptae 45-95 part, Rhizoma Chuanxiong 20-70 part, Semen Sesami Nigrum 60-110 part, Semen Cuscutae 35-85 part, Radix Rehmanniae Preparata 55-105 part, Caulis Spatholobi 40-90 part.
Preferably, the weight portion of each crude drug is: Radix Angelicae Sinensis 75 parts, 50 parts, Fructus Mori, 35 parts, Folium Mori, Fructus Lycii 50 parts, Fructus Ligustri Lucidi 70 parts, Radix Rehmanniae 40 parts, the Radix Astragali 60 parts, Radix Polygoni Multiflori (system) 90 parts, Cacumen Platycladi 50 parts, Herba Ecliptae 70 parts, Rhizoma Chuanxiong 45 parts, Semen Sesami Nigrum 80 parts, Semen Cuscutae 60 parts, Radix Rehmanniae Preparata 80 parts, Caulis Spatholobi 65 parts.
Inventor, by clinical research for many years, in conjunction with the dialectical principle combined with differential diagnosis of diseases, sums up with nourishing the liver and kidney, and QI invigorating is supported flourish, and active hair growth promoting is the Chinese medicine composition of the main rule for the treatment of, tries out in clinical, achieves ideal therapeutic effect for alopecia.
In Chinese medicine composition of the present invention: Radix Angelicae Sinensis: sweet, acrid, warm; Enter the heart, liver, spleen channel, there is effect of benefiting blood and regulating blood circulation, menstruction regulating and pain relieving.
Fructus Mori: sweet in the mouth acid, cold nature, enters the heart, liver, kidney channel, is strengthening by means of tonics, the good fruit of the heart nourishing and intellengence improving.There is YIN nourishing of enriching blood, promoting the production of body fluid to quench thirst, the effects such as intestine moistening is dry, cure mainly deficiency of YIN-blood and having a dizzy spell of causing, tinnitus cardiopalmus, irritated insomnia, soreness of the waist and knees, early whitening of beard and hair, xerostomia of quenching one's thirst, the diseases such as constipation with dry stool.
Folium Mori: bitter in the mouth, sweet, cold in nature; Return lung meridian, Liver Channel; There is liver heat removing nourishing the liver, dispelling wind and heat pathogens, lung heat clearing, the effects such as improving eyesight, cure mainly anemopyretic cold; Pathogenic wind-warm from the beginning of, fever and headache, perspiration and aversion to wind, cough chest pain; Or dryness of the lung dry cough without phlegm; Dry throat and mouth; Wind heat and liver-yang are disturbed; The diseases such as conjunctival congestion and swelling pain.
Fructus Lycii: sweet, flat, enters liver, kidney channel, has nourishing kidney, lung moistening, tonifying liver, effect of improving eyesight.
Fructus Ligustri Lucidi: be the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi Ligustrum lucidum Ait..Gather during fruit maturation in winter, removing branch and leaf, after slightly steaming or putting in boiling water and slightly scald, dry; Or convection drying.Sweet, bitter, cold.Return liver, kidney channel.Function with cure mainly: nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Radix Rehmanniae, Radix Rehmanniae Preparata all derive from the dry root of scrophulariaceae rehmannia glutinosa plant, are the different processed goods of same medicine.Radix Rehmanniae is the dry product of fresh goods, Radix Rehmanniae Preparata be Radix Rehmanniae steam product.The two is energy Yin-nourishing and body fluid promoting all, controls all diseases of Yin and fluid deficiency.Radix Rehmanniae is longer than removing heat from blood, and Radix Rehmanniae Preparata is longer than and is enriched blood.Radix Rehmanniae clearing up internal heat by using drugs of bitter in taste and cold in nature, Gan Hanzhi moistens yin nourishing, is the refrigerant product moistened, is good at nourishing YIN and clearing away heat removing heat from blood.Effect clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, intestine moistening.Radix Rehmanniae Preparata sweet in the mouth tepor matter is moistened, and enters Liver and kidney two warp, both kind YIN nourishing of enriching blood, again can vital essence replenishing and marrow benifiting, cures mainly the disease that all blood deficiency the moon lose oligospermia.The soreness of waist, the foot that also can control blood and essence asthenia be soft, feel dizzy, the disease such as deafness and tinnitus, early whitening of beard and hair.
The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali tragalus membranaceus (Fisch.) Bge..Sweet, temperature.Return lung, spleen channel.There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the functions such as expelling pus and promoting granulation.
Radix Polygoni Multiflori: be the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb..Slightly warm in nature is sweet in the mouth, puckery.Return liver, kidney channel.Have enrich and benefit essence and blood, nourishing the liver is calmed the nerves, bone and muscle strengthening, the function of the crow palpus that reinforces the kidney.
Cacumen Platycladi: be the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco.Bitter, puckery, cold.Return lung, liver, spleen channel.Function with cure mainly: cooling blood for hemostasis, growing and blacking hair.For hematemesis and epistaxis, spitting of blood, has blood in stool, metrostaxis, heat in blood alopecia, early whitening of beard and hair.
Herba Ecliptae: nature and flavor are sweet, sour, cold; Return kidney, Liver Channel.Function cures mainly:: nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort., pungent, temperature.Return liver, gallbladder, pericardium channel.There is blood-activating and qi-promoting, the function of wind-expelling pain-stopping.
Semen Sesami Nigrum: nature and flavor are sweet, flat, return liver, kidney, large intestine channel.It is invigorating the liver and kidney that its major function cures mainly, and benefiting essence-blood, intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation and other diseases.
Gui Jing: abnormal smells from the patient is pungent is sweet, flat nontoxic.Function with cure mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.
Caulis Spatholobi: the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn, meridian distribution of property and flavor: bitter, sweet, temperature.Return liver, kidney channel.Function cures mainly: enrich blood, and invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
" Plain Questions 〃 the five internal organs generate a section " cloud: " the tissue connected with the kidney being bone, its flourish also ", " Plain Questions 〃 innocence in ancient times opinion " cloud: " kidney qi declines, trichomadesis withering of teeth ", therefore treatment should based on the kidney invigorating, " Waike Zhengzong, Orthodox Manual of External Diseases 〃 alopecia areata " side: " alopecia areata is that blood deficiency can not support skin with gas honor, therefore hair root is empty, come off in flakes ", " the secret record of Feng Shi embroidered purse " side: " sending out is after blood, suddenly come off, scalp is itched more, man the person of falling, it is blood hot air wind producing, resembling also of wind wood shake ", therefore wind should be searched for assistant with promoting flow of QI and blood, number medicine of the present invention share, by taking good care of whole body QI and blood Liver and kidney, play nourishing the liver and kidney altogether, promoting flow of QI and blood, bald merit is controlled in hair growth promoting, obtain good therapeutic effect.
Crude drug used by the present invention all can be bought from common pharmacy and obtain, and its specification meets national medical standards.
Further, the invention provides a kind of method preparing the tablet of above-mentioned Chinese medicine composition.Comprise the following steps:
(1) each crude drug is taken by following weight parts: Radix Angelicae Sinensis 50-100 part, Fructus Mori 30-80 part, Folium Mori 10-60 part, Fructus Lycii 20-70 part, Fructus Ligustri Lucidi 45-95 part, Radix Rehmanniae 15-65 part, Radix Astragali 40-90 part, Radix Polygoni Multiflori (system) 70-120 part, Cacumen Platycladi 25-75 part, Herba Ecliptae 45-95 part, Rhizoma Chuanxiong 20-70 part, Semen Sesami Nigrum 60-110 part, Semen Cuscutae 35-85 part, Radix Rehmanniae Preparata 55-105 part, Caulis Spatholobi 40-90 part;
(2) pulverize
The Radix Polygoni Multiflori (system) of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cacumen Platycladi and 1/3 weight portion is placed in pulverizer co-grinding, sieves, obtain crude drug powder;
(3) extract
The Radix Polygoni Multiflori (system) of Fructus Mori, Folium Mori, Fructus Lycii, Fructus Ligustri Lucidi, Radix Rehmanniae, the Radix Astragali, Herba Ecliptae, Semen Sesami Nigrum, Semen Cuscutae, Radix Rehmanniae Preparata, Caulis Spatholobi and remaining 2/3 weight portion is put in extraction pot, decoct with water, decoction liquor is filtered, and filtrate concentrates, and obtains extractum;
(4) granulation, granulate
After being mixed homogeneously with crude drug powder by starch, use extractum spray granulation, dried granule is carried out granulate;
(5) mixing, tabletting
Granule after granulate is mixed, afterwards mixed granulate is carried out tabletting, the heavy 0.3g of every sheet;
(6) coating, packaging
Substrate is carried out coating according to the order of sub-coat, sugarcoating layer, coloured sugarcoating layer, polishing.Coated tablet is carried out aluminum-plastic packaged.
In the present invention, preferably, sieving as crossing 80 mesh sieves described in step (2).
In the present invention, preferably, the Radix Polygoni Multiflori (system) of Fructus Mori, Folium Mori, Fructus Lycii, Fructus Ligustri Lucidi, Radix Rehmanniae, the Radix Astragali, Herba Ecliptae, Semen Sesami Nigrum, Semen Cuscutae, Radix Rehmanniae Preparata, Caulis Spatholobi and remaining 2/3 weight portion is put in extraction pot by step (3), add 10-12 times amount soak by water twice, each decoction 2-3 hour, merges decoction liquor, and decoction liquor is filtered, filtrate is concentrated into relative density 1.00 ~ 1.30, obtains extractum.
In the present invention, preferably, the granulate described in step (4) is more than 20%, and must not have the fine powder crossing No. six sieves by the granule of No. two sieves after granulate.
In the present invention, preferably, being mixed into described in step (5) mixes 20-40 minute.
The present invention is made up of Chinese medicine, part medical material is that fine powder is used as medicine, all the other medical materials need decoct for several times, until be concentrated to suitable extractum, coated tablet is prepared after mixing with fine powder, because part medical material is containing volatile component in preparation process, design experiment controls the parameters such as Extracting temperature, time, amount of water, receives cream rate to improve.Improve the quality standard of product simultaneously, make reliable product quality, controlled.
Further, present invention also offers above-mentioned Chinese medicine composition and prepare the purposes in hair growth medicine.
In the present invention, preferably, described alopecia comprises alopecia areata, alopecia totalis, alopecia universalis, traumatic alopecia or Cicatricial baldness.
The usage of Chinese medicine composition of the present invention and consumption: the consumption of Chinese medicine composition of the present invention depends on the order of severity of the state of an illness and the result of drug sensitive detection.As guidance: tablet: light-duty patient per 6, every day 3 times is oral, moderate patient per 7, and every day 3 times is oral, each 8 of the obvious person of scalp inflammation, and every day 3 times is oral, within two weeks, is a course for the treatment of.
Detailed description of the invention
Below by experiment, also the present invention will be further described in conjunction with the embodiments, it should be understood that these embodiments only for the object of illustration, never limit the scope of the invention.
Embodiment 1
Each crude drug is taken: Radix Angelicae Sinensis 50g, Fructus Mori 30g, Folium Mori 10g, Fructus Lycii 20g, Fructus Ligustri Lucidi 45g, Radix Rehmanniae 15g, Radix Astragali 40g, Radix Polygoni Multiflori (system) 70g, Cacumen Platycladi 25g, Herba Ecliptae 45g, Rhizoma Chuanxiong 20g, Semen Sesami Nigrum 60g, Semen Cuscutae 35g, Radix Rehmanniae Preparata 55g, Caulis Spatholobi 40g by following weight; The Radix Polygoni Multiflori (system) of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cacumen Platycladi and 1/3 weight portion is placed in pulverizer co-grinding, crosses 80 mesh sieves, obtain crude drug powder; The Radix Polygoni Multiflori (system) of Fructus Mori, Folium Mori, Fructus Lycii, Fructus Ligustri Lucidi, Radix Rehmanniae, the Radix Astragali, Herba Ecliptae, Semen Sesami Nigrum, Semen Cuscutae, Radix Rehmanniae Preparata, Caulis Spatholobi and remaining 2/3 weight portion is put in extraction pot, add 10 times amount soak by water twice, each decoction 2 hours, merge decoction liquor, decoction liquor is filtered, filtrate is concentrated into relative density 1.00 ~ 1.30, obtains extractum; After being mixed homogeneously with crude drug powder by starch, use extractum spray granulation, dried granule is carried out granulate, after granulate, more than 20%, and the fine powder crossing No. six sieves must not be there is no by the granule of No. two sieves; Mixed by granule after granulate, incorporation time is 20 minutes, afterwards mixed granulate is carried out tabletting, the heavy 0.3g of every sheet; Substrate is carried out coating according to the order of sub-coat, sugarcoating layer, coloured sugarcoating layer, polishing, coated tablet is carried out aluminum-plastic packaged.
Embodiment 2
Each crude drug is taken: Radix Angelicae Sinensis 100g, Fructus Mori 80g, Folium Mori 60g, Fructus Lycii 70g, Fructus Ligustri Lucidi 95g, Radix Rehmanniae 65g, Radix Astragali 90g, Radix Polygoni Multiflori (system) 120g, Cacumen Platycladi 75g, Herba Ecliptae 95g, Rhizoma Chuanxiong 70g, Semen Sesami Nigrum 110g, Semen Cuscutae 85g, Radix Rehmanniae Preparata 105g, Caulis Spatholobi 90g by following weight parts; The Radix Polygoni Multiflori (system) of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cacumen Platycladi and 1/3 weight portion is placed in pulverizer co-grinding, crosses 80 mesh sieves, obtain crude drug powder; The Radix Polygoni Multiflori (system) of Fructus Mori, Folium Mori, Fructus Lycii, Fructus Ligustri Lucidi, Radix Rehmanniae, the Radix Astragali, Herba Ecliptae, Semen Sesami Nigrum, Semen Cuscutae, Radix Rehmanniae Preparata, Caulis Spatholobi and remaining 2/3 weight portion is put in extraction pot, add 12 times amount soak by water twice, each decoction 3 hours, merge decoction liquor, decoction liquor is filtered, filtrate is concentrated into relative density 1.00 ~ 1.30, obtains extractum; After being mixed homogeneously with crude drug powder by starch, use extractum spray granulation, dried granule is carried out granulate, after granulate, more than 20%, and the fine powder crossing No. six sieves must not be there is no by the granule of No. two sieves; Mixed by granule after granulate, incorporation time is 40 minutes, afterwards mixed granulate is carried out tabletting, the heavy 0.3g of every sheet; Substrate is carried out coating according to the order of sub-coat, sugarcoating layer, coloured sugarcoating layer, polishing, coated tablet is carried out aluminum-plastic packaged.
Embodiment 3
Each crude drug is taken: Radix Angelicae Sinensis 75g, Fructus Mori 50g, Folium Mori 35g, Fructus Lycii 50g, Fructus Ligustri Lucidi 70g, Radix Rehmanniae 40g, Radix Astragali 60g, Radix Polygoni Multiflori (system) 90g, Cacumen Platycladi 50g, Herba Ecliptae 70g, Rhizoma Chuanxiong 45g, Semen Sesami Nigrum 80g, Semen Cuscutae 60g, Radix Rehmanniae Preparata 80g, Caulis Spatholobi 65g by following weight parts; The Radix Polygoni Multiflori (system) of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cacumen Platycladi and 1/3 weight portion is placed in pulverizer co-grinding, crosses 80 mesh sieves, obtain crude drug powder; The Radix Polygoni Multiflori (system) of Fructus Mori, Folium Mori, Fructus Lycii, Fructus Ligustri Lucidi, Radix Rehmanniae, the Radix Astragali, Herba Ecliptae, Semen Sesami Nigrum, Semen Cuscutae, Radix Rehmanniae Preparata, Caulis Spatholobi and remaining 2/3 weight portion is put in extraction pot, add 11 times amount soak by water twice, each decoction 2.5 hours, merge decoction liquor, decoction liquor is filtered, filtrate is concentrated into relative density 1.00 ~ 1.30, obtains extractum; After being mixed homogeneously with crude drug powder by starch, use extractum spray granulation, dried granule is carried out granulate, after granulate, more than 20%, and the fine powder crossing No. six sieves must not be there is no by the granule of No. two sieves; Mixed by granule after granulate, incorporation time is 30 minutes, afterwards mixed granulate is carried out tabletting, the heavy 0.3g of every sheet; Substrate is carried out coating according to the order of sub-coat, sugarcoating layer, coloured sugarcoating layer, polishing, coated tablet is carried out aluminum-plastic packaged.
Test example traditional Chinese medicine composition for treating alopecia of the present invention clinical summary is reported
1. test method:
Detailed history-taking and health check-up are carried out to hair loss patient 170 example: wherein male 130 examples (76.5%), female 40 example (23.5%), man: female is 3.25:1, age of onset is 15-66 year, average 28.7 years old, wherein < 20 years old 40 example (23.5%), 20-40 year 110 examples (64.7%), > 40 years old 20 example (11.8%), the course of disease 2 weeks-6 years, case is respectively alopecia areata 92 example (54.1%), alopecia universalis 3 example (1.8%), alopecia totalis 19 example (11.2%), other type alopecia 56 example (32.9%).
Lab testing project: routine blood test, total LgE and erythrocyte sedimentation rate, whether etc. the existence that skin rash typus is focused in scalp clinical examination, area is got involved in alopecia, tufted is sent out, skin microscopy observes hair follicle situation emphatically, send out and new piliation with or without disconnected, and antibacterial culturing and determination of drug sensitivity are carried out to the erythra bleb liquid of 10 routine patients, clinical severity evaluation is carried out: alopecia area≤5% according to get involved area and skin rash typus of the scalp of patient, 5% < alopecia area≤10% or volume pustule, alopecia area is greater than 10%
Scalp biopsy and pathologic finding: 9 routine patients carry out scalp biopsy and sign Informed Consent Form, cut skin lesion place and be about 8mm × 6mm size tissue after 2% lignocaine local anesthesia, Hematoxylin-eosin (HE) dyeing is carried out in section.
2. clinical manifestation and diagnostic criteria
Alopecia areata: the alopecia of limitation patch shape, occurs suddenly, through low, its feature is that lesion scalp is normal, NIP, no conscious sympton.
Alopecia universalis: the whole body hair person that all do not come off is alopecia universalis.
Alopecia totalis: whole scalp and hair-care all comes off and is called alopecia totalis.
Other type alopecia: as traumatic alopecia, Cicatricial baldness etc.
This product treatment target is above four kinds.
3. therapeutic scheme and medication
Trial drug: the tablet prepared according to embodiment 1 method.
Therapeutic scheme is selected: light-duty patient per 6 according to the order of severity of the state of an illness and the result of drug sensitive detection, every day 3 times is oral, moderate patient per 7, every day 3 times is oral, each 8 of the obvious person of scalp inflammation, every day 3 times is oral, weekly or assessment in every two weeks once, until Morbidity control satisfied after monthly pay a return visit.
Lab testing: blood routine examination shows no obvious abnormalities, 2 routine patient LgE increase, and wherein 1 example has atopic dermatitis medical history, and erythrocyte sedimentation rate is without exception.
Pathologic finding and bacteria cultivation results: the visible hair follicle keratotic plug of pathologic finding, perifollicolar is shown in obvious neutrophil infiltration, companion's Focal Lymphocytic Infiltration; pathological changes meets folliculitis decalvans; in 10 routine patients of secretions antibacterial culturing, 6 routine patient's positive bacterial culture, and Bacteria Identification result is respectively staphylococcus aureus, Ke Shi citric acid bacillus, coagulase negative staphylococcus or aerobacteria; drug sensitivity tests display is responsive to Multiple Classes of Antibiotics, and 4 routine patients look into bacterium feminine gender.
4. therapeutic effect
Curative effect judging standard:
Recovery from illness: abnormal alopecia stops, and alopecia capitis totalis district renewable hair is dense, pitch-black, density is normal;
Effective: abnormal alopecia stops, and alopecia capitis totalis district renewable hair compared with normal is slightly sparse;
Effective: abnormal alopecia stops, the regeneration of alopecia capitis totalis district new children send out;
Invalid: without improvement or poorer before and after alopeciaing therapeutic.
Therapeutic outcome is in table 1, and total effective rate is healing, effective and effective summation.
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating alopecia of the present invention
| Case load | Cure | Effective | Effectively | Invalid | Total effective rate % | |
| Alopecia areata | 92 | 71 | 11 | 4 | 6 | 93.5 |
| Alopecia totalis | 19 | 11 | 4 | 2 | 2 | 89.5 |
| Alopecia universalis | 3 | 0 | 1 | 1 | 1 | 66.7 |
| Other type alopecia | 56 | 35 | 13 | 3 | 5 | 91.1 |
As seen from the table: alopecia areata total effective rate is 93.5%, alopecia totalis is 89.5%, and alopecia universalis is 66.7%, and other type alopecia is 91.1%, illustrate that Chinese medicine composition of the present invention all has significant curative effect for alopecia areata, alopecia totalis, alopecia universalis and other type alopecia, and have no any untoward reaction.Prove that Chinese medicine composition of the present invention is a kind of hair growth compositions safely and effectively.
Form from the age, Nervous and Mental Factors and deficiency of the liver and kindey are a very important cause of disease and inducement in all types of alopecia case, many patients feel that rhythm of life is fast, and stress is large, lives irregular, health is in sub-health state, therefore adopting nourishing the liver and kidney when treating, QI invigorating is supported flourish, by taking good care of whole body QI and blood Liver and kidney, fundamentally to its treatment, therapeutic purposes can be reached.
The foregoing is only the preferred embodiments of the present invention, is only illustrative for the purpose of the present invention, and nonrestrictive; Those of ordinary skill in the art understand, and can carry out many changes in the spirit and scope that the claims in the present invention limit to it, amendment, and even equivalence is changed, but all will fall within the scope of protection of the present invention.
Claims (9)
1. the Chinese medicine composition of a hair growth, it is characterized in that, be made up of the crude drug of following weight portion: Radix Angelicae Sinensis 50-100 part, Fructus Mori 30-80 part, Folium Mori 10-60 part, Fructus Lycii 20-70 part, Fructus Ligustri Lucidi 45-95 part, Radix Rehmanniae 15-65 part, Radix Astragali 40-90 part, Radix Polygoni Multiflori (system) 70-120 part, Cacumen Platycladi 25-75 part, Herba Ecliptae 45-95 part, Rhizoma Chuanxiong 20-70 part, Semen Sesami Nigrum 60-110 part, Semen Cuscutae 35-85 part, Radix Rehmanniae Preparata 55-105 part, Caulis Spatholobi 40-90 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Angelicae Sinensis 75 parts, 50 parts, Fructus Mori, 35 parts, Folium Mori, Fructus Lycii 50 parts, Fructus Ligustri Lucidi 70 parts, Radix Rehmanniae 40 parts, the Radix Astragali 60 parts, Radix Polygoni Multiflori (system) 90 parts, Cacumen Platycladi 50 parts, Herba Ecliptae 70 parts, Rhizoma Chuanxiong 45 parts, Semen Sesami Nigrum 80 parts, Semen Cuscutae 60 parts, Radix Rehmanniae Preparata 80 parts, Caulis Spatholobi 65 parts.
3. prepare a method for the tablet of Chinese medicine composition according to claim 1, it is characterized in that, comprise the following steps:
(1) each crude drug is taken by following weight parts: Radix Angelicae Sinensis 50-100 part, Fructus Mori 30-80 part, Folium Mori 10-60 part, Fructus Lycii 20-70 part, Fructus Ligustri Lucidi 45-95 part, Radix Rehmanniae 15-65 part, Radix Astragali 40-90 part, Radix Polygoni Multiflori (system) 70-120 part, Cacumen Platycladi 25-75 part, Herba Ecliptae 45-95 part, Rhizoma Chuanxiong 20-70 part, Semen Sesami Nigrum 60-110 part, Semen Cuscutae 35-85 part, Radix Rehmanniae Preparata 55-105 part, Caulis Spatholobi 40-90 part;
(2) pulverize
The Radix Polygoni Multiflori (system) of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cacumen Platycladi and 1/3 weight portion is placed in pulverizer co-grinding, sieves, obtain crude drug powder;
(3) extract
The Radix Polygoni Multiflori (system) of Fructus Mori, Folium Mori, Fructus Lycii, Fructus Ligustri Lucidi, Radix Rehmanniae, the Radix Astragali, Herba Ecliptae, Semen Sesami Nigrum, Semen Cuscutae, Radix Rehmanniae Preparata, Caulis Spatholobi and remaining 2/3 weight portion is put in extraction pot, decoct with water, decoction liquor is filtered, and filtrate concentrates, and obtains extractum;
(4) granulation, granulate
After being mixed homogeneously with crude drug powder by starch, use extractum spray granulation, dried granule is carried out granulate;
(5) mixing, tabletting
Granule after granulate is mixed, tabletting, the heavy 0.3g of every sheet;
(6) coating, packaging
Substrate is carried out coating according to the order of sub-coat, sugarcoating layer, coloured sugarcoating layer, polishing; Coated tablet is carried out aluminum-plastic packaged.
4. method according to claim 3, is characterized in that, sieving as crossing 80 mesh sieves described in step (2).
5. method according to claim 3, it is characterized in that, the Radix Polygoni Multiflori (system) of Fructus Mori, Folium Mori, Fructus Lycii, Fructus Ligustri Lucidi, Radix Rehmanniae, the Radix Astragali, Herba Ecliptae, Semen Sesami Nigrum, Semen Cuscutae, Radix Rehmanniae Preparata, Caulis Spatholobi and remaining 2/3 weight portion is put in extraction pot by step (3), add 10-12 times amount soak by water twice, each decoction 2-3 hour, merges decoction liquor, and decoction liquor is filtered, filtrate is concentrated into relative density 1.00 ~ 1.30, obtains extractum.
6. method according to claim 3, is characterized in that, the granulate described in step (4) is more than 20%, and must not have the fine powder crossing No. six sieves by the granule of No. two sieves after granulate.
7. method according to claim 3, is characterized in that, being mixed into described in step (5) mixes 20-40 minute.
8. the Chinese medicine composition described in any one of claim 1-2 is preparing the purposes in hair growth medicine.
9. alopecia according to claim 8 comprises alopecia areata, alopecia totalis, alopecia universalis, traumatic alopecia or Cicatricial baldness.
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| CN105616703A (en) * | 2016-02-26 | 2016-06-01 | 覃淑兰 | Traditional Chinese medicine composition for treating hair loss and preparation method thereof |
| CN105902778A (en) * | 2016-07-13 | 2016-08-31 | 江传国 | External applied medicine for treating alopecia |
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| CN116270855B (en) * | 2023-02-27 | 2024-05-10 | 宁波市中医院 | Traditional Chinese medicine composition for treating alopecia |
| CN116920027A (en) * | 2023-08-31 | 2023-10-24 | 乐泰药业有限公司 | Traditional Chinese medicine composition for treating cataract caused by liver-kidney yin deficiency and qi and blood stasis, and preparation method and quality control method thereof |
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Address after: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Patentee after: Letai Pharmaceutical Co.,Ltd. Address before: 150025 Zhuhai Road, Limin District, Hulan District, Heilongjiang, Harbin Patentee before: HARBIN KUAIHAO PHARMACEUTICAL Co.,Ltd. |