CN103735835A - Traditional Chinese medicinal preparation for treating premature graying and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicinal preparation for treating premature graying. The preparation comprises the following bulk pharmaceuticals in parts by weight: 10-20 parts of epimedium herb, 10-20 parts of dangshen, 10-20 parts of prepared multiflower knotweed tuber, 10-20 parts of Chinese angelica, 10-20 parts of glossy privet fruit, 10-20 parts of milk vetch seed, 10-20 parts of walnut kernel, 10-20 parts of virgate wormwood herb, 10-20 parts of barbary wolfberry fruit, 10-20 parts of mulberry, 10-20 parts of south dodder seed, 10-20 parts of Chinese arborvitae twig, 10-20 parts of rehmannia root, 10-20 parts of sealwort, 10-20 parts of dogwood, 10-20 parts of red-rooted salvia root, 10-20 parts of white paeony root, 10-20 parts of Chinese magnoliavine fruit, 10-20 parts of yerbadetajo herb and 10-20 parts of nutgrass galingale rhizome. The traditional Chinese medicinal preparation has the effects of promoting the circulation of qi, opening depression, calming the liver, tonifying kidney, disinfecting, sterilizing, tonifying qi and promoting blood circulation, and contributes to opening pores, nourishing the scalp, blackening hairs and beautifying. The traditional Chinese medicinal preparation has special hair growing and blackening effects on premature graying, alopecia due to neurasthenia and the like.

Description

A kind of Chinese medicine preparation for the treatment of teen-ager leukotrichia and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of Chinese medicine preparation for the treatment of teen-ager leukotrichia and preparation method thereof.

Background technology

Determine hair color be in hair pigment granule number, the latter is relevant with the chromatophorous development growth situation of root of hair nipple.Hair is bleached by black, is generally pigment cell's deterioration of hair, and when decline is to completely can not chromogenesis granule time, hair has just bleached completely.Normal person was since 35 years old, and trichochromes cell falls into a decline.And next year old of somebody 20 is just white, medically claims juvenile canities, is commonly called as " teen-ager leukotrichia ".Heat in blood, deficiency of kidney-QI are weak, QI and blood is weak is all the reason that causes poliosis.The source of nutrition of hair, in blood, if hair bleaches or comes off, is because of deficiency of liver-blood, a little less than deficiency of kidney-QI mostly.Therefore, the Therapeutic Method of the traditional Chinese medical science is tonifying liver blood, the kidney invigorating gas.

Chinese traditional treatment poliosis according to theory of Chinese medical science is: " liver storing blood, hair is the sign of blood condition ", " kidney controlling essence storage, its Hua Fa ", " heart governing blood and vessels ", " lung governing skin and hair "." spleen is source of generating QI and blood ".That is to say that the growth of hair and color and luster change, with the function prosperity and decline of the vital organs of the human body, yang-energy essence and blood warm moisten support closely bound up.If internal organs function is vigorous, yang-energy essence and blood is full, and hair obtains fully moistening supports that black profit is beautiful, is difficult for de-mistake.On the contrary, if congenital defect will lose and support the day after tomorrow, internal organs function is weak, negative and positive of qi and blood virtual loss, and poliosis is early raw, sparse easy to break for the hair that is difficult to supplement nutrition.And it is wherein more close with the relation of spleen, kidney, liver.All congenital defects, deficiency of kidney-essence, marrow lose the person of filling less, or irascible temperament, heat in blood are contained partially, impairment of YIN hematozemia person, or sorrow is pondered over, dysfunction of the spleen in transportation, the weary source person of QI and blood, or excessive thinking and anxiety, insomnia and dreamful sleep, liver blood consumption person secretly, all can injure the five internal organs, deficient QI and blood, loses hair foster and early white.

The generation of teen-ager leukotrichia, except heredity is that congenital factors cannot change, other factors can change by reasonable adjusting.Doctor trained in Western medicine is referred to as presenile poliosis, is a kind of child and nonage poliosis disease, and its cause of disease is very complicated, has two large types, the congenital teen-ager leukotrichia of a kind, another kind posteriority teen-ager leukotrichia.In posteriority teen-ager leukotrichia, having many is to follow certain disease pathogenetic, and some is due to due to spiritual hypertonicity and malnutrition.

Posteriority teen-ager leukotrichia.The reason causing is a lot: malnutrition, as lacked protein, vitamin and some trace element (as copper) etc., all can make hair bleach; Some Chronic consumptions is as tuberculosis etc., and because causing malnutrition, hair is white earlier than common people also; The patient of some long-term fevers, hair meeting Huang is crisp even to bleach and comes off; Some endocrinopathyes, as hypophysis cerebri or thyroid illness, can affect the ability of pigment cell's chromogenesis granule and cause hair to bleach too early; Encephalitis, nervous system lesion etc. also can make hair bleach; Albinism patient's skin, hair, eyebrow are all white; The disease of whiteness of skin-" vitiligo ", as occur on scalp, hair also can bleach; Somebody thinks, requires mental skill more, and hair Bai get Yue early; At short notice, hair bleaches some adolescent in a large number, overtired relevant with the serious psychic trauma such as overanxiexty, sadness or spirit.

As for congenital presenile poliosis, mostly because heredity causes, as the property lost chronic illness morning, cotton material Cotard, Wardenburg Cotard often have number hereditary history of generation in family, hereditary detect, albinism also belong to congenital hereditary disease.Except acquired abnormal for posteriority local skin disease through several months and several years majority can recover normal, the cause of disease of these presenile poliosis is all due to due to genetic gene mutation causes body tyrosine metabolic pathway are all obstructed in (as albinism) or part.

If find in child and youth, teen-ager leukotrichia should check to hospital early, makes a definite diagnosis after its pathogenesis etiology, as long as the cause of disease is eradicated, can cure teen-ager leukotrichia.Product and the medicine of function in the market with poliosis and hair growth promoting is a lot, but for Western medicine, great majority are used hormones product, the one, price comparison is expensive, continue to use several courses for the treatment of, bring very large financial burden to client patient, the 2nd, long-time use easily brought certain side effect to physical function; For the pure Chinese medicine on market, drug effect is slow, and formula compatibility is bad, unstable again.Needs of patients has and has hair-blackening tonic, and energy life-time service is effective, is free from side effects again, and cheap Chinese herbal medicine formula preparation solves the good recipe of teen-ager leukotrichia problem.

Summary of the invention

Technical problem to be solved by this invention is, a lot of for product and the medicine of function in the market with black hair, hair growth promoting, for Western medicine, great majority are used hormone medicine, the one, price comparison is expensive, continues to use several courses for the treatment of, brings very large financial burden to client patient; The 2nd, long-time use easily brought certain side effect to physical function.These product curative effects are very micro-, and classify too much, and treated effect is low, and cost is compared with high and the course for the treatment of is longer, and what have also occurs macule, and even scalp skin bubbles, and makes ward mate produce fear.And Chinese medicine takes effect slowly, effect is not remarkable, there is no specific aim.The present invention takes the liver and the kidney tonifying, and the compatibility of drugs of the refreshment of having one's ideas straightened out, activating QI to alleviate the depression, suppressing the hyperactive liver the kidney invigorating, disinfection, inrigorating qi and promoting blood circulation, reaches blackening and generating hair, nutrition scalp, the Chinese medicine preparation of the object of hair regeneration.The present invention's each effective ingredient science compatibility to component medicine is a kind of instant effect, without any side effects, the lasting Chinese medicine preparation of a specified duration of effect, the largely upper misery that solves patient.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of teen-ager leukotrichia, in described preparation, the parts by weight of various crude drug are: 10～20 parts of Herba Epimedii, 10～20 parts of Radix Codonopsis, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Semen Astragali Complanatis, 10～20 parts of Semen Juglandis, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Fructus Lycii, 10～20 parts of Fructus Mori, 10～20 parts of Semen Cuscutae, 10～20 parts of Cacumen Platycladis, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Rhizoma Polygonatis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Herba Ecliptaes, 10～20 parts of Rhizoma Cyperis.

The Chinese medicine preparation of described treatment teen-ager leukotrichia, described in it, in preparation, the parts by weight of various crude drug can be: 10～15 parts of Herba Epimedii, 10～15 parts of Radix Codonopsis, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Semen Astragali Complanatis, 10～15 parts of Semen Juglandis, 10～15 parts of Herba Artemisiae Scopariaes, 10～15 parts of Fructus Lycii, 10～15 parts of Fructus Mori, 10～20 parts of Semen Cuscutae, 10～20 parts of Cacumen Platycladis, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Rhizoma Polygonatis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Herba Ecliptaes, 10～20 parts of Rhizoma Cyperis.

The Chinese medicine preparation of described treatment teen-ager leukotrichia, described in it, in preparation, the parts by weight of various crude drug can also be: 10～20 parts of Herba Epimedii, 10～20 parts of Radix Codonopsis, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Semen Astragali Complanatis, 10～20 parts of Semen Juglandis, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Fructus Lycii, 10～20 parts of Fructus Mori, 10～15 parts of Semen Cuscutae, 10～15 parts of Cacumen Platycladis, 10～15 parts, the Radix Rehmanniae, 10～15 parts of Rhizoma Polygonatis, 10～15 parts of Fructus Corni, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Fructus Schisandrae Chinensis, 10～15 parts of Herba Ecliptaes, 10～15 parts of Rhizoma Cyperis.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of teen-ager leukotrichia, and the process for producing granula of described Chinese medicine preparation comprises the following steps:

A, get raw material and put into water and soak, heat is extracted 2 times, becomes paste, is component 1;

B, medicinal residues add ethanol extraction 2 times, and thickening filtration is paste, are component 2;

C, above-mentioned two kinds of pastes are condensed into pasty state add dextrin or Mel to granulate, sterilizing.

In described step a, can get in the water that described crude drug adds 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid,, 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use, becomes component 1.

In described step b, the medicinal residues that ethanol extraction can be crossed are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, and 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use, becomes component 2.

In described step c, above-mentioned two kinds of component pastes can be condensed into pasty state, add after Mel or dextrin are in harmonious proportion and put into granulator, after granulating, with ultraviolet disinfection, then pack.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method for the treatment of the Chinese medicine preparation of teen-ager leukotrichia again, described Chinese medicine preparation is that the preparation process of pill is: first described crude drug is dropped into multi-function extractor and extract twice, add for the first time 8-10 times of water gaging and decoct 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge decocting liquid twice, filter to get filtrate; Decompression is put into concentrator and is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven coolingly, grinds to form fine powder, calls in Mel and makes honey refining pill, bottling.

Above-mentioned steps decompression is put into concentrator when concentrated, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.

The Chinese medicine preparation of described treatment teen-ager leukotrichia, the dosage form for the treatment of the Chinese medicine preparation of teen-ager leukotrichia described in it can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, suppository, plaster or cream.

The present invention has the liver and the kidney tonifying, and the refreshment of having one's ideas straightened out, activating QI to alleviate the depression, suppressing the hyperactive liver the kidney invigorating, disinfection, inrigorating qi and promoting blood circulation reach blacking hair and nourishing face, pore pauses out, nutrition scalp, the advantage of hair regeneration.The present invention can give full play to medicine greatest treatment efficacy, has safety good, the advantage that feasibility is good, and compared with prior art religion, this technology has convenient drug administration, through patient part, the advantage such as targeting is strong, and medicament is easy to manufacture, with low cost.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, without any side effects, easy to use, after curing, be difficult for recurrence, and cheap, easy to use, can create good social value and economic interests.

The specific embodiment

Scientist studies discovery in recent years, contains the mixture of copper and ferrum in the pigment granule of hair, and when black hair nickel content increases, hair will become canescence; In flavous hair, contain titanium; In foxy hair, contain molybdenum; In henna hair, except containing copper, also contain titanium.As can be seen here, the color of trace element and hair has substantial connection.In order to prevent the too early appearance of teen-ager leukotrichia, on diet, should note the food of taking in iron content and copper more.The food that iron content is many has animal liver, eggs, Auricularia, Thallus Laminariae (Thallus Eckloniae), Semen sojae atricolor, sesame paste etc.; The food that cupric is many has animal liver, kidney, shrimp Eriocheir sinensis class, hard fruit, Fructus Pruni to spread dry and dry bean etc.Note the absorption of vitamin B group.Physician now confirms, and the B1 that is deficient in vitamin, B2, B6 are also major reasons that causes teen-ager leukotrichia.Should increase the absorption of this group food, as frumentum, beans, dry fruit, animal liver, the heart, kidney, milk, eggs and leaf vegetable etc.

Teen-ager leukotrichia patient is also noted that the food that is rich in tyrosine of taking in more.Melanic forming process, is formed by the mould oxidation tyrosine of tyrosine.That is to say, the basis that melanin forms is tyrosine, and tyrosine lacks also can cause teen-ager leukotrichia.Therefore, should take in containing the abundant food of tyrosine, as Carnis Gallus domesticus, lean beef, thin pork, Carnis Leporis, fish and hard fruit food etc. more.

The source of nutrition of hair, in blood, if hair bleaches or comes off, is because of deficiency of liver-blood, a little less than deficiency of kidney-QI mostly.Therefore, the Therapeutic Method of the traditional Chinese medical science is tonifying liver blood, the kidney invigorating gas.Heat in blood, deficiency of kidney-QI are weak, QI and blood is weak is all the reason that causes poliosis.According to theory of Chinese medical science, be: " liver storing blood, hair is the sign of blood condition ", " kidney controlling essence storage, its Hua Fa ", " heart governing blood and vessels ", " lung governing skin and hair "." spleen is source of generating QI and blood ".That is to say that the growth of hair and color and luster change, with the function prosperity and decline of the vital organs of the human body, yang-energy essence and blood warm moisten support closely bound up.If internal organs function is vigorous, yang-energy essence and blood is full, and hair obtains fully moistening supports that black profit is beautiful, is difficult for de-mistake.On the contrary, if congenital defect will lose and support the day after tomorrow, internal organs function is weak, negative and positive of qi and blood virtual loss, and poliosis is early raw, sparse easy to break for the hair that is difficult to supplement nutrition.And it is wherein more close with the relation of spleen, kidney, liver.All congenital defects, deficiency of kidney-essence, marrow lose the person of filling less, or irascible temperament, heat in blood are contained partially, impairment of YIN hematozemia person, or sorrow is pondered over, dysfunction of the spleen in transportation, the weary source person of QI and blood, or excessive thinking and anxiety, insomnia and dreamful sleep, liver blood consumption person secretly, all can injure the five internal organs, deficient QI and blood, loses hair foster and early white.

The traditional Chinese medical science thinks that poliosis appears in teenager too early, often because of sorrow, ponders over, and in heat in blood, accumulates, and sends out foster the forming of becoming homeless.Controlling should heat clearing and blood cooling, nourishing the liver and kidney method, and Chinese medicine thinks, this disease is mainly due to due to deficiency of the liver and kindey, deficiency of both QI and blood.Geneogenous teen-ager leukotrichia is how relevant with heredity, is difficult for treatment; And teen-ager leukotrichia posteriority, except according to etiological treatment, also should be strengthened nutrition.Experiment shows, lacks protein and height malnutrition is one of cause of disease of early raw poliosis.In diet, lack trace copper, cobalt, ferrum etc. and also can cause poliosis.In addition numerous disease all may be with the appearance of presenile poliosis, as pernicious anemia, hyperthyroidism, cardiovascular disease (myocardial infarction, atrioventricular bundle conduction block, hypertension etc.), steinert's disease, vitiligo and Vogt-Koyanagi Cotard etc. in addition.In addition, the change of the human body mental status, as joyous in long-term depression, be worried excessively or emotion hypertonicity, often can cause that hair bleaches rapidly in terror.The factor of above-mentioned disease and nutrition and spirit can make vigour, pectoral qi, ying-qi three's disequilibrium, thereby makes damaged hair, Here it is we " having hindered vigour " of often saying in word.This presenile poliosis, without special treatment, only need find the cause of disease and eradicate it, can effect a radical cure.

In numerous reasons, the traditional Chinese medical science thinks that topmost reason is suffer from a deficiency of the kidney lung damage, toxin accumulation, trace element deficiency, causes alopecia above.The present invention sums up the cause of disease of forefathers' teen-ager leukotrichia, alopecia just mainly at kidney, if the empty insufficiency of vital energy and blood of Liver and kidney two, the blood circulation of whole body is just weak, unable nutrient substance is transported to the upright highest point of human body " crown ", on head, hair follicle can not get nourishing, and atrophy gradually will cause the experience of alopecia, teen-ager leukotrichia, sum up this prescription, " kidney storing essence, main reproduction, its Hua Fa ", " hair is the sign of blood condition ", think that the kidney being the origin of congenital constitution, the product that hair is blood.Kidney storing essence, blood stored in the liver, essence and blood sharing the same origin transforms mutually, and both are indispensable.

Fructus Lycii is the liver and the kidney tonifying Chinese medicine of commonly using simply, modern medicine study confirms that it contains the nutritional labelings such as betaine, polysaccharide, crude fat, crude protein, carotene, vitamin A, vitamin C, vitamin B1, vitamin B2 and calcium, phosphorus, ferrum, zinc, manganese, linoleic acid, hemopoietic function is had to facilitation, can also defying age, the effect such as mutation, antitumor, anti-fatty liver and blood sugar lowering.The traditional Chinese medical science usually with it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, poliosis, alopecia, the diseases such as seminal emission, it is remarkable that YIN nourishing is supported kidney effect.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, really the gas medicine in blood, the also panacea in blood.About mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Radix Codonopsis is flat, sweet in the mouth, micro-acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.The just > > of < < book on Chinese herbal medicine carries: Radix Codonopsis power energy spleen reinforcing nourishing the stomach, and the lung moistening and production of body fluid promoting, gas in tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, spleen invigorating fortune and not dry, grows stomach-Yin and wet, and lung moistening and do not violate is cold and coolly nourished blood and is not partially grown greasyly, inspires clear sun, gas in vibration, and without just dry fraud.Radix Astragali QI invigorating, can rise enriching spleen-QI, again can lung benefiting consolidating superficial resistance.Radix Codonopsis QI invigorating, can only spleen invigorating QI invigorating, and without the power of consolidating superficial resistance, but Radix Codonopsis can also supplementing QI for promoting the production of body fluid, and the Radix Astragali is without the effect of promoting the production of body fluid, and the Radix Astragali is held concurrently can diuretic, and Radix Codonopsis is without diuretic effect.This two tastes medicine share can invigorating the spleen and replenishing QI, improves resistance.

Semen Astragali Complanati, Latin formal name used at school: these product of Astragalus chinensis Linn.f. are the dry mature seed of leguminous plant astragatus complanatus Astragalus complanatus R.Brown..Warm in nature, sweet in the mouth.Function cures mainly temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision.< < detailed outline > >: the kidney invigorating, control lumbago and let out essence, deficient tired.< < book on Chinese herbal medicine is asked former > >: control consumptive lung disease, kidney is cold, frequent micturition, incontinence of urine, improving eyesight, longue meat.Can protect liver glycogen accumulation, blood fat reducing, fall enzyme; Energy decreased heart rate, reduces blood pressure, and increases cerebral blood flow; Can improve hemorheology index, suppress platelet aggregation; Energy enhancing human body immunity power, improves body specificity and non-specific immunity; The effect such as have resisting fatigue, put on weight, resist cold; There are the effects such as analgesia, calmness, antipyretic, antiinflammatory, diuresis.

Fructus Mori nourishing YIN and benefiting blood medicine; Medicine promotes the production of body fluid; Aperitive.The YIN nourishing of enriching blood, promotes the production of body fluid and moisturizes.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.Tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Both can food, can be used as medicine again, the traditional Chinese medical science is thought the acid of Fructus Mori sweet in the mouth, cold nature, enters the heart, liver, kidney channel, is strengthening by means of tonics, the good fruit of the heart nourishing and intellengence improving.There is the YIN nourishing of enriching blood, promoting the production of body fluid to quench thirst, the effect such as intestine moistening is dry, cures mainly deficiency of YIN-blood and having a dizzy spell of causing, tinnitus cardiopalmus, irritated insomnia, soreness of the waist and knees, early whitening of beard and hair, the xerostomia of quenching one's thirst, the diseases such as constipation with dry stool.

Cacumen Platycladi: Cupressaceae plant Cacumen Platycladi, formal name used at school: the browse of Platycladus orientalis (L.) Franco.Medical material Cacumen Platycladi Ye Duoyou branch, little and different in size, be flakey.Color is bronzing.The visible leaf in surface is mutually to life, section yellow-white.Quality is crisp, easily fractureed.Feeble QI is fragrant, a kind of in the blood-cooling hemostatic of bitter and puckery flavor Chinese medicine hemorrhage, the effect that has hemostasis, black beard and hair, cough-relieving to breathe heavily.Removing heat from blood, hemostasis, wind-damp dispelling, loose toxic swelling.Control haematemesis, epistaxis, hematuria, dysentery, hemorrhoidal hamorrhage, metrorrhagia, rheumatic arthralgia, bacillary dysentery, hypertension, cough, erysipelas, mumps, scalds.< < does not record > >: " main haematemesis, epistaxis, dysentery blood, metrorrhagia are red white.The QI invigorating of making light of one's life by commiting suicide, makes us cold-resistant summer-heat, the numbness of drying, granulation promoting."

Fructus Corni, cures mainly pathogen cold and heat under the heart, and warming middle-JIAO, by cold warm numbness, goes three worms, the merit that for a long time clothes have been made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stopped dribbling urination; Take for a long time improving eyesight, brute force all the year round.Fructus Corni, has another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., is the conventional rare Chinese medicine of China, and applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties use that medical science is liked.Zhang Zhongjing be take Fructus Corni and has been formulated " JINGUI SHENQI WAN " as monarch.According to chemical analysis, Fructus Corni contains the effective ingredient such as cornin, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin that physiologically active is stronger, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibacterial, is Herba indigoferae Pseudotinctoriae conventional in tcm clinical practice.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. < < detailed outline > > carries: Radix Salviae Miltiorrhizae, press the sensible opinion of < < married woman > > cloud, SIWU TANG is controlled gynecopathy, pay no attention to antenatal puerperal, how many through water, all can be general, only taste Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls, stops metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.

The Radix Paeoniae Alba, clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control that the stagnant amenorrhea of the stasis of blood, hernia abdominal mass gather, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.The Radix Paeoniae Alba minute excess-heat that can purify the blood, dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between are use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, minute excess-heat that can purify the blood, can control fever due to yin deficiency again; And the Radix Paeoniae Alba can only, for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.< < herbal classic > >: main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.

The pungent micro-hardship of Rhizoma Cyperi is sweet, and flat function cures mainly: the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.< < detailed outline > > carries it: the cold epidemic disease of loose seasonal epidemic pathogens, and sharp three warmers, separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in front puerperal.

Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata minute, direct slicing is used as medicine for Radix Polygoni Multiflori, with Semen sojae atricolor liquor, mixes after steaming and dries and be used as medicine for Radix Polygoni Multiflori Preparata.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, be usually used in treating scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.

Herba Epimedii is pungent, sweet, warm, returns liver, kidney channel.Energy reinforcing the kidney and supporting YANG, strengthening the tendons and bones, expelling wind and removing dampness, is apt to control insufficiency of kidney-YANG, impotence and seminal emission, enuresis frequent micturition; Rheumatic arthralgia, atrophic debility of bones paralysis disease.< < book on Chinese herbal medicine is stated > > cloud, and " excessive sheep fire; the main impotence of < < herbal classic > > medicine is hindered absolutely; the sub-> > of < < solar corona also its treatment of head speech man is positive absolutely; woman is cloudy absolutely, calling into the gate of vitality, benefit kidney-Yang person is also.The lid gate of vitality be the kidney-Yang in kidney, the vigour of the person also, its so-called exhausted YANG exhaustion the moon, the vigour of basis not, how hiss in both withered.So-called physical strength profiting, strong will, and control cold air consumptive disease, and the anxious card that waits of muscles and bones contraction, all it helps the event of vigour.Old man's dusk octogenarian, the middle age is forgetful, all Yuanyang decay and can not ascensionist also.Must know that this taste is to reduce to liter, its liter is owing to falling also.

Semen Juglandis nature and flavor are sweet, temperature.Return kidney, lung, large intestine channel.The kidney invigorating, warming the lung, intestine moistening.For soreness of the waist and knees, impotence and seminal emission, deficiency and coldness is breathed heavily and is coughed, constipation.Semen Juglandis contains a large amount of vitamin Es, often the edible effect that has lung moistening, hair color.In Semen Juglandis, contain more protein and the unsaturated fatty acid of needed by human, these compositions have extraordinary supplementing the brain effect, can nourish brain cell, cerebral function improvement.

Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis.. pharmaceutical research has function of gallbladder promoting, and liver function protecting is antipyretic, antiinflammatory, and blood fat reducing, the effects such as coronary dilating, have significant hepatoprotective effect, to first, hepatitis B, icterohepatitis, has significant curative effect.There is function of gallbladder promoting, promote bile secretion, the effect that in increase bile, cholic acid and bilirubin are discharged. can increase heart coronary flow, improve microcirculation, and have blood pressure lowering, blood fat reducing, anticoagulation, diuresis is antipyretic relievings asthma, and drives away ascarid and suppresses the effect of multiple pathogenic dermatophytes and antibacterial.

Semen Cuscutae has the effect of the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, solid tire stopping leak.Semen Cuscutae acrid in the mouth, sweet, slightly warm in nature; Return liver,kidney,spleen warp; Gas and property are slow, can float to sink to have the kidney invigorating and essence nourishing nourishing the liver to improve visual acuity, the solid tire of spleen invigorating.Cure mainly lumbago tinnitus, impotence and seminal emission, quenches one's thirst, sterile, enuresis incontinence, and stranguria with turbid discharge leukorrhagia, the head is dim, and lack of appetite is had loose bowels, frequent fetal movement.Semen Cuscutae in the > > of < < Sheng Nong's herbal classic, be listed in top grade return through: abnormal smells from the patient is pungent, sweet, flat nontoxic.Function with cure mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones that is applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.Taking for a long time improving eyesight makes light of one's life by commiting suicide and prolongs life.

Rhizoma Polygonati is used as medicine with rhizome.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, the interior-heat disease such as quench one's thirst.Very effective in cure for diabetes.Stir-baked RHIZOMA POLYGONATI with yellow rice wine claims again to process Rhizoma Polygonati.For steaming rear section with adjuvants such as wine and Semen sojae atricolors, clean Rhizoma Polygonati dries the person of being used as medicine.Have the merit of the meridians of escaping concurrently.Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, and blood fat reducing, atherosclerosis, slow down aging and the effect such as antibacterial, polygonatum polysaccharide has Immunestimulatory effect.For lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough of YIN-deficiency of the lung and kidney etc.For weakness of the spleen and stomach.Both tonifying spleen-yin, strengthening the spleen gas again, for deficiency of kidney essence, obtain dizzy, soreness of the waist and knees, early whitening of beard and hair and quenching one's thirst etc.Rhizoma Polygonati strengthening bone and muscle, beneficial marrow, bleaches and sends out; The cough expectorant being suitable for due to lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.

The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosaLibosch..Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; The effect of Radix Rehmanniae and Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, is often for consumption of YIN caused by febrile disease, the diseases such as haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.With respect to Radix Rehmanniae, Radix Rehmanniae is heat clearing and blood cooling, also can promote the production of body fluid, and all right yin nourishing is used for treating yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sends out the problems such as speckle dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect, every blood system to have the people of thermal burn the moon to metrorrhagia, menoxenia, frequent fetal movement, constipation etc., can often take.If want to treat epidemic febrile disease, can do qingying decoction with the Radix Rehmanniae; If the later stage for the treatment of epidemic febrile disease, because waste heat does not also disappear to the greatest extent, should be used for boiling QINGHAOBIEJIATANG the Radix Rehmanniae; In addition, for heat in blood poison, contain, macule purple is black, and the serious heat of epidemic febrile disease enters the symptom of nutrient blood, can take the Sisheng Wan that the Radix Rehmanniae is made; The general YIN nourishing and the production of body fluid promoting of wanting treats that interior-heat quenches one's thirst with constipation, should eat the once liquid soup that the Radix Rehmanniae boils.

Fructus Schisandrae Chinensis temperature; Sour, sweet; Return lung, the heart, kidney channel; Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.< < Bencao Jingshu > > carries: the main QI invigorating person of Fructus Schisandrae Chinensis, and all gas of lung master, acid can be received, and is just entering lung tonifying the lung, therefore QI invigorating is also.Its main cough with dyspnea person, the deficiency of vital energy is above stopped up and is not returned unit, and sour flavor having the property of astringing, takes the photograph gas and returns unit, and cough with dyspnea is from removing.Impairment caused by overstrain is won thin, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence.< < does not record > > and supports the five internal organs, heat extraction, flesh person in raw the moon, the special the kidney invigorating of Fructus Schisandrae Chinensis, the tonifying five ZANG-organs of holding concurrently, kidney storing essence, essence is contained cloudy strong, receipts are taken the photograph vital qi and are returned unit, and public region is warm, digesting food, steam waste matter and change precise and tiny, smart spontaneous, essence is raw cloudy long, therefore main as above all diseases also.

Herba Ecliptae is the conventional liver-nourishing kidney-boosting of the traditional Chinese medical science, cooling blood for hemostasis medicine.Multiple due to all diseases of Light-headedness, odontoseisis, aching pain in waist and back, flaccidity and weakness of the lower limbs due to the hepatic and renal YIN deficiency and heat in blood gone out to blood disorder and have good efficacy.Herba Ecliptae contains the chemical compositions such as volatile oil, tannin, Saponin, Herba Ecliptae element and vitamin A.Animal experiment has haemostatic effect, and in vitro tests has inhibitory action to staphylococcus aureus.

Fructus Ligustri Lucidi is for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to use, controls early whitening of beard and hair, often joins the same use of Fructus Mori, and fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.Protective effect research to liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, give rat skin lower injection, can reduce serum glutamic pyruvic transminase, the hepatic injury of Carbon Tetrachloride Induced being had to obvious protective effect, and can promote liver cell regeneration. oleanolic acid also can make in liver triglyceride accumulate that minimizings, hepatocellular degeneration necrosis obviously alleviate, glycogen is accumulated increase, serum γglobulin decline; Mitochondrial swelling and the degeneration of endoplasmic reticulum vesicle alleviates, the inflammatory reaction of hepatic tissue interstitial weakens in the visible hepatocyte of ultrastructure.

Process for producing granula of the present invention is: get raw material Herba Epimedii 1000g, Radix Codonopsis 1000g, Radix Polygoni Multiflori Preparata 1000g, Radix Angelicae Sinensis 1000g, Fructus Ligustri Lucidi 1000g, Semen Astragali Complanati 1000g, Semen Juglandis 1000g, Herba Artemisiae Scopariae 1000g, Fructus Lycii 1000g, Fructus Mori 1000g, Semen Cuscutae 1000g, Cacumen Platycladi 1000g, Radix Rehmanniae 1000g, Rhizoma Polygonati 1000g, Fructus Corni 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Paeoniae Alba 1000g, Fructus Schisandrae Chinensis 1000g, Herba Ecliptae 1000g, Rhizoma Cyperi 1000g.Get in the water that described crude drug adds 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid,, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, is component 1; The medicinal residues that water extraction is crossed are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, stand for standby use, becomes component 2; Above-mentioned two kinds of component pastes are condensed into pasty state, add after Mel or dextrin are in harmonious proportion and put into granulator, after granulating, with ultraviolet disinfection, then pack.

The preparation method of pill of the present invention is: get raw material Herba Epimedii 1200g, Radix Codonopsis 1300g, Radix Polygoni Multiflori Preparata 1300g, Radix Angelicae Sinensis 1400g, Fructus Ligustri Lucidi 1200g, Semen Astragali Complanati 1300g, Semen Juglandis 1400g, Herba Artemisiae Scopariae 1200g, Fructus Lycii 1300g, Fructus Mori 1300g, Semen Cuscutae 1200g, Cacumen Platycladi 1300g, Radix Rehmanniae 1300g, Rhizoma Polygonati 1400g, Fructus Corni 1400g, Radix Salviae Miltiorrhizae 1200g, Radix Paeoniae Alba 1300g, Fructus Schisandrae Chinensis 1400g, Herba Ecliptae 1400g, Rhizoma Cyperi 1300g, drops into pulverizer and is ground into fine powder, and granularity is 100～120 orders; Sieve, unsifted coarse granule adds 20 liters, water and soaks 45 minutes, and heated and boiled 35 minutes, filters filtrate for later use; Filtering residue adds water and heats for the second time, boils 35 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 45 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state, put into after 80 ℃ of oven dry of baking oven cooling, and the fine powder sieving; Add Mel mediation and be twisted into pill.

The preparation method of oral solutions of the present invention: by all raw material Herba Epimedii 1300g, Radix Codonopsis 1300g, Radix Polygoni Multiflori Preparata 1300g, Radix Angelicae Sinensis 1400g, Fructus Ligustri Lucidi 1200g, Semen Astragali Complanati 1200g, Semen Juglandis 1300g, Herba Artemisiae Scopariae 1200g, Fructus Lycii 1300g, Fructus Mori 1300g, Semen Cuscutae 1200g, Cacumen Platycladi 1400g, Radix Rehmanniae 1300g, Rhizoma Polygonati 1400g, Fructus Corni 1300g, Radix Salviae Miltiorrhizae 1200g, Radix Paeoniae Alba 1300g, Fructus Schisandrae Chinensis 1400g, Herba Ecliptae 1400g, Rhizoma Cyperi 1300g.Put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, merges standing by 2 extracting solution; The medicinal residues of the component raw medicinal material of more above-mentioned ethanol extraction being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; Above-mentioned two kinds of extracting solution are merged concentrated, above-mentioned steps reclaims after ethanol decompression and puts into concentrator when concentrated, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.Add dextrin and be in harmonious proportion, bottling.

The present invention's focus of going directly, targeting is strong, and promoting blood circulation to remove blood stasis has no side effect, and medicine can be infiltrated rapidly and make absorption of human body, and instant effect, and therapeutic effect is good, with low cost, reparation technology is simple and easy to do.

Pharmacology's toxicity test

1. irritation test

Get rabbit and shave hair, with pill of the present invention, induce and excite contact test, viewing test rabbit after 24 hours and 48 hours, all loseing skin has the phenomenons such as erythema and edema, with negative control group zero difference.Result shows, this patch is bordering on zero to dermoreaction intensity, without skin allergic reaction.

2. endo-medicine cumulative toxicity test report

Test method: select 20 healthy mices, female, male each 10, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, and the LD50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.

3. acute toxicity test

Give white mouse oral administration medicine supplying with 300 times of the clinical consumption per day of this product endo-medicine, observe 5.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse damaged skin is carried out to irritation test, there are no irritative response and other untoward reaction.

Toxicity test proves, the not toxic effect of said preparation and untoward reaction, and clinical practice is safe and reliable.

Clinical trial:

Teen-ager leukotrichia is common clinical.We choose the case of in June, 2008-2012 outpatient service between 4 years year June, and with growing and blacking hair Chinese medicine preparation treatment primary disease 100 examples, curative effect is comparatively satisfied.Now be reported as follows.

1, data and method

1.1 physical data

100 examples all meet document dependent diagnostic standard, get rid of vitiligo, albinism, pseudopelade, black dot tinea, epilation tinea, leprosy alopecia, folliculitis decalvans, tinea favosa bald etc., are divided at random two groups.Treatment group 50 examples, male's 29 examples, women's 21 examples; Age 13-25 year, average 18.45 years old; The course of disease 3 months to 6 years, average 3.1 years.Matched group 50 examples, male's 31 examples, women's 19 examples; Age 12-25 year, average 19.21 years old; The course of disease 3 months to 5 years, average 2.6 years.Two groups of above-mentioned data no significant differences (p > 0.05), have comparability.

1.2 Therapeutic Method

The oral growing and blacking hair preparation for the treatment of group, system in the court institute, side uses: Herba Epimedii 11g, Radix Codonopsis 12g, Radix Polygoni Multiflori Preparata 13g, Radix Angelicae Sinensis 11g, Fructus Ligustri Lucidi 12g, Semen Astragali Complanati 11g, Semen Juglandis 11g, Herba Artemisiae Scopariae 12g, Fructus Lycii 12g, Fructus Mori 12g, Semen Cuscutae 13g, Cacumen Platycladi 13g, Radix Rehmanniae 13g, Rhizoma Polygonati 12g, Fructus Corni 12g, Radix Salviae Miltiorrhizae 12g, Radix Paeoniae Alba 12g, Fructus Schisandrae Chinensis 13g, Herba Ecliptae 12g, Rhizoma Cyperi 12g.Make each 2 balls of pill, every day 3 times.The oral cystine 100mg of matched group, oryzanol 10mg, every day 3 times.All treat 90D for two groups, all stop external treatment in other therebetween.

Hair growth situation before and after 1.3 observation item records contrast therapy, detects routine blood test and IgG, IgA, IgM before and after treatment, and relatively its variation.

1.4 criterion of therapeutical effect reference literature relevant portions are worked out.Recovery from illness: blackening hair, newborn hair is black, reaches beauty treatment requirement, hair pulling test is negative.Effective: newborn hair fine hair on birds or animals hair growth, blackening hair is obvious, and hair pulling test is negative.Effective: blackening hair is comparatively obvious, there is brown doping wherein, it is half black that fine hair on birds or animals hair is grown, and hair pulling test is negative or positive.Invalid: only have minority blackening hair, with streaks of white hair, hair pulling test is positive.

1.5 statistical procedures data represent with-X ± S, adopt x ²check and t check.

2 results

2.1 liang of group curative effects are relatively in Table 1.Result shows that treatment group curative effect is better than matched group (p < 0.01).

Table 1 liang group curative effect is n (%) relatively

Group

n

Recovery from illness

Effective

Effectively

Invalid

Effectively total

Treatment group

50

36（72）

8（16）

4（8）

2（4）

96*

Matched group

50

21（42）

6（12）

3（6）

20（40）

60

With matched group comparison, * p < 0.01

2.2 treatment group red blood cell count(RBC) and hemoglobin index change in Table 2.

After treatment group treatment, red blood cell count(RBC), hemoglobin are treated front obvious raising (p < 0.01).

Red blood cell count(RBC), hemoglobin level comparison (X ± S) after the treatment of table 2 treatment group

Relatively front with treatment, * p < 0.01.

2.3 treatment group serum IgGs, IgA, IgM index change in Table 3.After treatment group treatment, IgG, IgA, IgM all obviously improve p < 0.01 before treating.

IgG, IgA, IgM level comparison (G/L ,-X ± S) before and after the treatment of table 3 treatment group

Time	n	IgG	IgA	IgM
					Before treatment	50	5.13±0.13	0.78±0.18	0.87±0.17
After treatment	50	8.13±0.19*	2.01±0.27*	1.45±0.23*

Relatively front with treatment, * p < 0.01.

3 discuss

Heat in blood, deficiency of kidney-QI are weak, QI and blood is weak is all the reason that causes poliosis.The source of nutrition of hair, in blood, if hair bleaches or comes off, is because of deficiency of liver-blood, a little less than deficiency of kidney-QI mostly.Therefore, the Therapeutic Method of the traditional Chinese medical science is tonifying liver blood, the kidney invigorating gas.Chinese traditional treatment poliosis according to theory of Chinese medical science is: " liver storing blood, hair is the sign of blood condition ", " kidney controlling essence storage, its Hua Fa ", " heart governing blood and vessels ", " lung governing skin and hair "." spleen is source of generating QI and blood ".That is to say that the growth of hair and color and luster change, with the function prosperity and decline of the vital organs of the human body, yang-energy essence and blood warm moisten support closely bound up.The traditional Chinese medical science think generation and Liver and kidney asthenia of essence and blood, the hair of primary disease lose support relevant.Therefore Radix Polygoni Multiflori Preparata, Fructus Mori enriching blood and replenishing vital essence in growing and blacking hair oral liquid; Radix Astragali vital base and primordial QI consolidating, air making-up and spleen enlivening; Semen juglandis the kidney invigorating benefit blood, embellishes but not dry; Radix Salviae Miltiorrhizae, Radix Rehmanniae clearing away heat and cooling blood, nourshing blood and promoting blood circulation is in order to hair growth; The sweet slow coordinating the actions of various ingredients in a prescription of Rhizoma Polygonati.Full side's compatibility, the merit of playing altogether liver and kidney tonifying, vital base and primordial QI consolidating, benefiting qi and nourishing blood, growing and blacking hair.By observation, show, it is improved the effect of erythrocyte, hemoglobin, thereby has confirmed the theoretical of Chinese medicine " hair is the sign of blood condition " and by the trichogenous effectiveness of enriching blood from Point of View of Clinical.

Specific embodiment 1: Chen, man, 16 years old, main suit when medical in 2009: hair starts slowly to bleach from graduating from primary school, now almost complete white.Often feel tired out, eye xerophthalmia is puckery, and inappetence is weak.Hypomnesis is obvious.Tried Chinese medicine, western medicine, effect is all not obvious, the obvious dysplasia of child, more thin and weak once external application or take medicine orally treatment by Chinese herbs, symptom slightly alleviates, but increases the weight of while meeting anxious state of mind.Feel the pulse because deficiency of liver-blood, a little less than deficiency of kidney-QI, is used following Drug therapy:

Side uses: Herba Epimedii 13g, Radix Codonopsis 12g, Radix Polygoni Multiflori Preparata 13g, Radix Angelicae Sinensis 12g, Fructus Ligustri Lucidi 12g, Semen Astragali Complanati 11g, Semen Juglandis 11g, Herba Artemisiae Scopariae 12g, Fructus Lycii 12g, Fructus Mori 12g, Semen Cuscutae 13g, Cacumen Platycladi 13g, Radix Rehmanniae 13g, Rhizoma Polygonati 12g, Fructus Corni 12g, Radix Salviae Miltiorrhizae 12g, Radix Paeoniae Alba 12g, Fructus Schisandrae Chinensis 13g, Herba Ecliptae 12g, Rhizoma Cyperi 12g.Instrucion should be noted the food of taking in iron content and copper more on diet.Animal liver, eggs, Auricularia, Thallus Laminariae (Thallus Eckloniae), Semen sojae atricolor, sesame paste etc., hard fruit, Fructus Pruni spread dry and dry bean etc.Vitimin supplement B1, B2, B6.

Treat January, sensation spirit is much better.Memory improves obviously.No longer often tired; The puckery phenomenon of eye xerophthalmia is improved.Hair starts obvious blackening, and black and white doping, has become hoary, continue to use 3 months, and the whole blackening of newborn hair, transference cure, starts to become normal type, follows up a case by regular visits to 3 years without recurrence, cures.

Specific embodiment 2: go into business certain, female, 20 years old, readme was subject to father heredity, occurs since the childhood poliosis, and along with the growth at age, poliosis is more and more.Go various big hospital treatment, hormone, treatment by Chinese herbs effect is all not obvious, and hair is now grizzled, and sensation is own to old lady.Need often hair dyeing, injury scalp, and have cancered danger.Emotion is dispirited, weak, and liver-fire is vigorous, epiphora induced by wind.Like anger, memory is bad, occurs on the face mottle.Feel the pulse because deficiency of liver-blood, a little less than deficiency of kidney-QI, is used following Drug therapy.

Side uses: Herba Epimedii 12g, Radix Codonopsis 13g, Radix Polygoni Multiflori Preparata 11g, Radix Angelicae Sinensis 12g, Fructus Ligustri Lucidi 12g, Semen Astragali Complanati 11g, Semen Juglandis 11g, Herba Artemisiae Scopariae 12g, Fructus Lycii 12g, Fructus Mori 12g, Semen Cuscutae 13g, Cacumen Platycladi 13g, Radix Rehmanniae 13g, Rhizoma Polygonati 12g, Fructus Corni 12g, Radix Salviae Miltiorrhizae 12g, Radix Paeoniae Alba 12g, Fructus Schisandrae Chinensis 12g, Herba Ecliptae 12g, Rhizoma Cyperi 12g.Instrucion should be noted the food of taking in iron content and copper more on diet.Animal liver, eggs, Auricularia, Thallus Laminariae (Thallus Eckloniae), Semen sojae atricolor, sesame paste etc., hard fruit, Fructus Pruni spread dry and dry bean etc.Vitimin supplement B1, B2, B6.

Treat January, spirit improves.Complexion starts to take a turn for the better, and mottle disappears.Memory improves obviously.No longer often tired; The puckery phenomenon of eye xerophthalmia is improved.Hair starts obvious blackening, and black and white doping, has become hoary, continue to use 3 months, and the whole blackening of newborn hair, transference cure, follows up a case by regular visits to 2 years without recurrence, cures.Youth that becomes is now beautiful; Optimistic confidence.

Claims (10)

1. a Chinese medicine preparation for the treatment of teen-ager leukotrichia, it is characterized in that, in described preparation, the parts by weight of various crude drug comprise: 10～20 parts of Herba Epimedii, 10～20 parts of Radix Codonopsis, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Semen Astragali Complanatis, 10～20 parts of Semen Juglandis, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Fructus Lycii, 10～20 parts of Fructus Mori, 10～20 parts of Semen Cuscutae, 10～20 parts of Cacumen Platycladis, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Rhizoma Polygonatis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Herba Ecliptaes, 10～20 parts of Rhizoma Cyperis.

2. treat according to claim 1 the Chinese medicine preparation of teen-ager leukotrichia, it is characterized in that, in described preparation, the parts by weight of various crude drug are: 10～15 parts of Herba Epimedii, 10～15 parts of Radix Codonopsis, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Semen Astragali Complanatis, 10～15 parts of Semen Juglandis, 10～15 parts of Herba Artemisiae Scopariaes, 10～15 parts of Fructus Lycii, 10～15 parts of Fructus Mori, 10～20 parts of Semen Cuscutae, 10～20 parts of Cacumen Platycladis, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Rhizoma Polygonatis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Herba Ecliptaes, 10～20 parts of Rhizoma Cyperis.

3. treat according to claim 1 the Chinese medicine preparation of teen-ager leukotrichia, it is characterized in that, in described preparation, the parts by weight of various crude drug are: 10～20 parts of Herba Epimedii, 10～20 parts of Radix Codonopsis, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Semen Astragali Complanatis, 10～20 parts of Semen Juglandis, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Fructus Lycii, 10～20 parts of Fructus Mori, 10～15 parts of Semen Cuscutae, 10～15 parts of Cacumen Platycladis, 10～15 parts, the Radix Rehmanniae, 10～15 parts of Rhizoma Polygonatis, 10～15 parts of Fructus Corni, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Fructus Schisandrae Chinensis, 10～15 parts of Herba Ecliptaes, 10～15 parts of Rhizoma Cyperis.

4. as described in any one in claim 1～3, treat a preparation method for the Chinese medicine preparation of teen-ager leukotrichia, it is characterized in that, the process for producing granula of described Chinese medicine preparation comprises the following steps:

A, get raw material and put into water and soak, heat is extracted 2 times, becomes paste, is component 1;

B, medicinal residues add ethanol extraction 2 times, and thickening filtration is paste, are component 2;

C, above-mentioned two kinds of pastes are condensed into pasty state add dextrin or Mel to granulate, sterilizing.

5. preparation method according to claim 4, is characterized in that, in described step a, get in the water that described crude drug adds 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid,, 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use, becomes component 1.

6. preparation method according to claim 4, it is characterized in that, in described step b, the medicinal residues that ethanol extraction is crossed are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, and 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use, becomes component 2.

7. preparation method according to claim 6, is characterized in that, in described step c, above-mentioned two kinds of component pastes is condensed into pasty state, add after Mel or dextrin are in harmonious proportion and put into granulator, after granulating with ultraviolet disinfection, then pack.

8. state the preparation method of Chinese medicine preparation for the treatment of teen-ager leukotrichia as any one in claim 1～3 for one kind, it is characterized in that, described Chinese medicine preparation is that the preparation process of pill is: first described crude drug is dropped into multi-function extractor and extract twice, add for the first time 8-10 times of water gaging and decoct 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge decocting liquid twice, filter to get filtrate; Decompression is put into concentrator and is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven coolingly, grinds to form fine powder, calls in Mel and makes honey refining pill, bottling.

9. preparation method according to claim 8, is characterized in that, above-mentioned steps decompression is put into concentrator when concentrated, the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.

10. according to the Chinese medicine preparation for the treatment of teen-ager leukotrichia described in any one in claim 1～9, it is characterized in that, the dosage form of the Chinese medicine preparation of described treatment teen-ager leukotrichia is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, suppository, plaster or cream.