CN105664099A - Traditional Chinese medicine composition for warming and invigorating kidney yang and preparation method thereof - Google Patents
Traditional Chinese medicine composition for warming and invigorating kidney yang and preparation method thereof Download PDFInfo
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/30—Extraction of the material
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention belongs to the technical field of traditional Chinese medicine and particularly relates to a traditional Chinese medicine composition for warming and invigorating kidney yang and a preparation method thereof. The traditional Chinese medicine composition comprises, by weight, 15-25 parts of cortex cinnamomi, 120-160 parts of prepared rehmannia roots, 60-90 parts of fructus corni (prepared), 20-40 parts of cortex eucommiae, 11-25 parts of herba cistanche, 30-46 parts of rhizoma alismatis, 20-45 parts of gordon enryale seeds, 20-40 parts of common ginger, 18-30 parts of angelica sinensis and 50-80 parts of morel. All raw materials of the traditional Chinese medicine composition for warming and invigorating kidney yang cooperate to be used, meet the 'assistant and guide' principle, are reasonable in compatibility and hit the kidney-yang deficiency pathogenesis, and the treatment effect is remarkable.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to Chinese medicine composition of a kind of warming and recuperating the kidney-YANG and preparation method thereof.
Background technology
Kidney yang is the motive power of human life activity, basic for human life, is considered the symbol of life, is subject to the attention of ancient Chinese medicine doctor, and the research of insufficiency of kidney-YANG is shown by modern doctor, and the appearance of insufficiency of kidney-YANG indicates that the various function of body is in low state. Syndrome of deficiency of kidney-YANG is kidney yang deficiency, warm dereliction of duty, and power is lost in gasification, because of obstinate disease, or usually owing to straining excessively, or worn with age caused by.
Chinese Pharmacopoeia 2005 editions discloses a kind of GUIFU DIHUANG WAN, and the formula of described GUIFU DIHUANG WAN is: Cortex Cinnamomi 20g, Radix Aconiti Lateralis Preparata (system) 20g, Radix Rehmanniae Preparata 160g, Fructus Corni (system) 80g, Cortex Moutan 60g, Rhizoma Dioscoreae 80g, Poria 60g, Rhizoma Alismatis 60g. Above eight tastes are ground into fine powder, sieve, mixing. Every 100g powder refined honey 35-50g adds appropriate water pill, dry, makes water-honeyed pill; Or add refined honey 80-110g and make small honey pill or big honeyed pills, to obtain final product. For insufficiency of kidney-YANG, waist knee joint is cold, limbs edema, and dysuria or anti-many, phlegm retention is breathed with cough, and quenches one's thirst.
Chinese patent CN1709485A discloses Chinese medicine composition of a kind of warming and recuperating the kidney-YANG and preparation method thereof, Chinese medicine composition that the invention discloses warming and recuperating the kidney-YANG and preparation method thereof, it is that to mainly comprise composition be Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Poria, Fructus Corni (system), Cortex Moutan, Rhizoma Alismatis, Cortex Cinnamomi, the osmanthus attached glutinous rehmannia drop pill of Radix Aconiti Lateralis Preparata (system) or micropill. The preparation method of this patent is: take part Rhizoma Dioscoreae, Poria powder is broken into fine powder; Cortex Cinnamomi distillating extracting oil, the another device of aqueous solution after distillation is collected; Medicinal residues and Cortex Moutan carry out oozing rumble and are made into the ethanol as solvent of 30-70% with above-mentioned aqueous solution, dipping, ooze rumble, collect rumble liquid, reclaim ethanol; Radix Aconiti Lateralis Preparata boiling, adds remaining Rhizoma Dioscoreae, Poria and all the other Radix Rehmanniae Preparata, Fructus Corni, Rhizoma Alismatis three taste medicine, decocts secondary, decocting liquid, filters, concentration, merge with rumble liquid, concentration, add Rhizoma Dioscoreae, the mixing of Poria fine powder, dry, finely ground, add Cortex Cinnamomi volatile oil, mixing, after adding suitable adjuvant, make drop pill or micropill. It is an advantage of the invention that carry, taking convenience, bioavailability is high, controllability and good stability, is conducive to improving curative effect. Chinese patent CN104873708A discloses and a kind of treats the Chinese medicine composition of the soreness of waist, preparation method and application, the raw material of the Chinese medicine composition of the described treatment soreness of waist includes each composition of following weight portion: Radix Rehmanniae Preparata 160 parts, Cortex Moutan 60 parts, 120 parts of Poria, Cortex Cinnamomi 20 parts, Radix Achyranthis Bidentatae 40 parts, Fructus Corni 80 parts, Rhizoma Dioscoreae 80 parts, Rhizoma Alismatis 60 parts, Radix Aconiti Lateralis Preparata 20 parts, Semen Plantaginis 40 parts, the Chinese medicine composition the kidney warming activating QI of this patent treatment soreness of waist, inducing diuresis to remove edema, for treating soreness of waist good effect, instant effect, cure rate is high, has no side effect.But, these patent clinical therapeutic efficacies are all inconspicuous.
Summary of the invention
For overcoming drawbacks described above, it is an object of the invention to provide the Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, therapeutic effect is notable.
Another object of the present invention also resides in the Chinese medicine composition preparation method providing a kind of warming and recuperating the kidney-YANG, and preparation method is simple.
For achieving the above object, the present invention adopts the following technical scheme that
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 15-25 part, Radix Rehmanniae Preparata 120-160 part, Fructus Corni (system) 60-90 part, Cortex Eucommiae 20-40 part, Herba Cistanches 11-25 part, Rhizoma Alismatis 30-46 part, Semen Euryales 20-45 part, Rhizoma Zingiberis Preparatum 20-40 part, Radix Angelicae Sinensis 18-30 part and Morchella esculenta (L.) Pers 50-80 part.
Chinese medicine composition according to above-mentioned warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 20-24 part, Radix Rehmanniae Preparata 130-150 part, Fructus Corni (system) 60-83 part, Cortex Eucommiae 30-39 part, Herba Cistanches 15-21 part, Rhizoma Alismatis 40-45 part, Semen Euryales 30-40 part, Rhizoma Zingiberis Preparatum 25-35 part, Radix Angelicae Sinensis 21-28 part and Morchella esculenta (L.) Pers 70-80 part.
Chinese medicine composition according to above-mentioned warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 21 parts, Radix Rehmanniae Preparata 138 parts, Fructus Corni (system) 75 parts, the Cortex Eucommiae 35 parts, Herba Cistanches 18 parts, Rhizoma Alismatis 42 parts, Semen Euryales 33 parts, Rhizoma Zingiberis Preparatum 27 parts, Radix Angelicae Sinensis 25 parts and Morchella esculenta (L.) Pers 71 parts.
Chinese medicine composition according to above-mentioned warming and recuperating the kidney-YANG, also includes Fructus Psoraleae 6-15 part and Semen Cuscutae 6-15 part.
The preparation method of the Chinese medicine composition of a kind of above-mentioned warming and recuperating the kidney-YANG, comprises the following steps:
(1) raw material of following parts by weight is prepared: Cortex Cinnamomi 15-25 part, Radix Rehmanniae Preparata 120-160 part, Fructus Corni (system) 60-90 part, Cortex Eucommiae 20-40 part, Herba Cistanches 11-25 part, Rhizoma Alismatis 30-46 part, Semen Euryales 20-45 part, Rhizoma Zingiberis Preparatum 20-40 part and Radix Angelicae Sinensis 18-30 part, dry, pulverize to powder;
(2) step (1) powder is adopted 5-10 times amount soak with ethanol 0.5-1.0h, supersound extraction 2-3 time, each 20-30min, filter, be concentrated into without alcohol taste, obtain extracting solution and medicinal residues;
(3) by step (2) medicinal residues add the distilled water of 5-10 times of weight, it is heated to reflux 2-4 time, each 2-4h, obtains extracting solution and medicinal residues;
(4) combining step (2) and step (3) extracting solution, at being concentrated into 30-50 DEG C, relative density is the thick original text of 1.2-1.5, and drying and crushing obtains powder;
(5) Morchella esculenta (L.) Pers 50-80 part is ground to powder, mix homogeneously with step (4) powder, obtain Chinese medicine composition;
(6) step (5) Chinese medicinal powder is loaded capsule, every 0.6-1.0g, obtain capsule.
The preparation method of the Chinese medicine composition according to above-mentioned warming and recuperating the kidney-YANG, the supersonic frequency 15-25kHz described in step (2), power 300-500W.
The preparation method of the Chinese medicine composition according to above-mentioned warming and recuperating the kidney-YANG, the granularity of step (4) and the powder described in step (5) is 80-120 order.
The instructions of taking of capsule of the present invention: oral meal, every 0.6-1.0g, every day 2-3 time, each 4-5 grain, 10 days is a course for the treatment of.
The pharmacological action of each crude drug of the present invention:
Cortex Cinnamomi, pungent, sweet, hot greatly, return kidney, spleen, the heart, Liver Channel; Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow, for sexual impotence, cold womb, chills and pain of the waist and kness, to suffer from a deficiency of the kidney and breathe heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Radix Rehmanniae Preparata, sweet, tepor, return liver, kidney channel; Nourishing YIN and supplementing blood, benefit essence fills out marrow, and for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizziness, tinnitus, early whitening of beard and hair.
Fructus Corni, sour, puckery, tepor, return liver, kidney channel; Liver and kidney tonifying, essence astringing and desertion stemming, for vertigo and tinnitus, soreness of waist and knee joint, sun is passed out semen repeatly, enuresis frequent micturition, bleeding not during menses, and profuse sweating is collapsed, and interior-heat is quenched one's thirst.
The Cortex Eucommiae, sweet, temperature, return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, antiabortive, for lumbago due to renal deficiency. muscles and bones is unable, blood leaking in gestation, frequent fetal movement, hypertension.
Herba Cistanches, sweet, salty, temperature, return kidney, large intestine channel; Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation, for sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.
Rhizoma Alismatis, sweet, cold, return kidney, bladder warp; Diuresis, clearing away damp-heat, for dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipidemia.
Semen Euryales, sweet, puckery, flat, return spleen, kidney channel; Supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, damp eliminating leukorrhagia stopping, for emission, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia.
Rhizoma Zingiberis Preparatum, returns board, stomach, kidney, the heart, lung meridian; Warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding, for Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea, and tells rule metrorrhagia, and yang deficiency is lost blood.
Radix Angelicae Sinensis, sweet, acrid, warm, return liver, the heart, spleen channel; Replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation, for blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores. Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow, for amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Morchella esculenta (L.) Pers, property flat, sweet in the mouth, return spleen, stomach warp, there is the kidney invigorating, tonifying YANG, supplementing the brain, the function refreshed oneself, essence deficiency of the kidney is damaged, sexual impotence is not lifted, libido cold, dizziness, insomnia, the intestines and stomach inflammation, weakness of the spleen and stomach, dyspepsia etc. have therapeutical effect, also can give protection against cancer, anticancer, preventing cold, are rare edible fungi most precious in the world, belong to high-grade nutrient tonic, its bacterial context is delicate, has fragrance, and food flavor is delicious and being rich in nutrition.
Fructus Psoraleae, pungent, bitter, temperature, return kidney, spleen channel, warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal, for impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea.
Semen Cuscutae, sweet, temperature, return liver,kidney,spleen warp; Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal; For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down.
The Chinese medicine composition of warming and recuperating the kidney-YANG of the present invention meets " monarch " principle, compatibility is reasonable, hit insufficiency of kidney-YANG pathogenesis, and Cortex Cinnamomi, Radix Rehmanniae Preparata, Fructus Corni, the Cortex Eucommiae, Herba Cistanches are monarch drug, and it is supporing yang that Cortex Cinnamomi mends fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow, Radix Rehmanniae Preparata nourishing YIN and supplementing blood, benefit essence fills out marrow, Fructus Corni liver and kidney tonifying, essence astringing and desertion stemming, Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening, Herba Cistanches kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation, Chinese medicine of the five flavours share, and plays warming and recuperating the kidney-YANG altogether, essence astringing and desertion stemming, cold expelling relieve the pain, effect of eliminating evil cough-relieving; Rhizoma Alismatis, Semen Euryales are ministerial drug, Rhizoma Alismatis diuresis, clearing away damp-heat, Semen Euryales supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, damp eliminating leukorrhagia stopping, and two taste Chinese medicines and monarch drug are used in conjunction with, and strengthen the effect of Chinese medicine composition diuresis infiltration of the present invention, invigorating the spleen and replenishing QI, expelling wind and removing dampness further;Rhizoma Zingiberis Preparatum warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding, Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, and two medicines share as making medicine, plays blood-activating and qi-promoting, active passages through which vital energy circulates effect altogether; Morchella esculenta (L.) Pers, the kidney invigorating, tonifying YANG, supplementing the brain, refreshes oneself, effect of coordinating the actions of various ingredients in a prescription; The each crude drug of Chinese medicine composition of warming and recuperating the kidney-YANG of the present invention is assisted a ruler in governing a country mutually, plays the merit of reinforcing the kidney and supporting YANG, expelling wind and removing dampness, supplementing the kidney to control the nocturnal, promoting blood circulation and stopping pain altogether, plays effect for the treatment of insufficiency of kidney-YANG.
The positive beneficial effect of the present invention:
1. each crude drug of the Chinese medicine composition of warming and recuperating the kidney-YANG of the present invention with the use of, meet " monarch " principle, compatibility is reasonable, hit insufficiency of kidney-YANG pathogenesis, compared with the Chinese medicine that prior art treats kidney yang, each crude drug warm in nature and, eliminate the use of drug toxicity Radix Aconiti Lateralis Preparata, be suitable for various body constitution patient.
2. Fructus Psoraleae warming the kidney to activate YANG in the Chinese medicine composition of warming and recuperating the kidney-YANG of the present invention, improving inspiration by invigorating kidney-QI, antidiarrheal, Semen Cuscutae nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, two taste crude drug Fructus Psoraleaes and Semen Cuscutae add in the middle of formula, reinforcing the kidney and supporting YANG better effects if.
3. the Chinese medicine composition preparation method of warming and recuperating the kidney-YANG of the present invention is simple, and extracts active ingredients is complete, and with low cost, it is neat and artistic that dosage form makes capsule appearance, it is easy to swallows, and can cover the bad taste of smelling of medicine, and disintegrate is fast, good absorbing, good stability.
4. the traditional Chinese medicine composition for treating effect of warming and recuperating the kidney-YANG of the present invention is notable, and total effective rate is up to 96%, and cure rate is up to 72%.
Detailed description of the invention
Below in conjunction with some detailed description of the invention, the present invention is further described.
Embodiment 1
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 15 parts, Radix Rehmanniae Preparata 120 parts, Fructus Corni (system) 60 parts, the Cortex Eucommiae 20 parts, Herba Cistanches 11 parts, Rhizoma Alismatis 30 parts, Semen Euryales 20 parts, Rhizoma Zingiberis Preparatum 20 parts, Radix Angelicae Sinensis 18 parts and Morchella esculenta (L.) Pers 50 parts.
The preparation method of the Chinese medicine composition of above-mentioned warming and recuperating the kidney-YANG, comprises the following steps:
(1) prepare the crude drug of above-mentioned parts by weight: Cortex Cinnamomi 15 parts, Radix Rehmanniae Preparata 120 parts, Fructus Corni (system) 60 parts, the Cortex Eucommiae 20 parts, Herba Cistanches 11 parts, Rhizoma Alismatis 30 parts, Semen Euryales 20 parts, Rhizoma Zingiberis Preparatum 20 parts and Radix Angelicae Sinensis 18 parts, dry, pulverize to powder;
(2) step (1) powder is adopted 5 times amount soak with ethanol 1.0h, supersound extraction 2 times, each 20min, supersonic frequency 15kHz, power 300W, filters, is concentrated into without alcohol taste, obtains extracting solution and medicinal residues;
(3) by step (2) medicinal residues add the distilled water of 5 times of weight, it is heated to reflux 2 times, each 3h, obtains extracting solution and medicinal residues;
(4) combining step (2) and step (3) extracting solution, is concentrated at 30 DEG C relative density and is the thick original text of 1.3, drying and crushing, and obtaining granularity is 80 order powder;
(5) Morchella esculenta (L.) Pers 50 parts is ground to 80 order powder, mix homogeneously with step (4) powder, load capsule, every 0.8g, to obtain final product.
Embodiment 2
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 16 parts, Radix Rehmanniae Preparata 125 parts, Fructus Corni (system) 63 parts, the Cortex Eucommiae 22 parts, Herba Cistanches 13 parts, Rhizoma Alismatis 31 parts, Semen Euryales 22 parts, Rhizoma Zingiberis Preparatum 23 parts, Radix Angelicae Sinensis 20 parts and Morchella esculenta (L.) Pers 58 parts.
The preparation method of the Chinese medicine composition of above-mentioned warming and recuperating the kidney-YANG, comprises the following steps:
(1) prepare the crude drug of above-mentioned parts by weight: Cortex Cinnamomi 16 parts, Radix Rehmanniae Preparata 125 parts, Fructus Corni (system) 63 parts, the Cortex Eucommiae 22 parts, Herba Cistanches 13 parts, Rhizoma Alismatis 31 parts, Semen Euryales 22 parts, Rhizoma Zingiberis Preparatum 23 parts and Radix Angelicae Sinensis 20 parts, dry, pulverize to powder;
(2) step (1) powder is adopted 6 times amount soak with ethanol 0.5h, supersound extraction 3 times, each 25min, supersonic frequency 20kHz, power 400W, filters, is concentrated into without alcohol taste, obtains extracting solution and medicinal residues;
(3) by step (2) medicinal residues add the distilled water of 6 times of weight, it is heated to reflux 3 times, each 2h, obtains extracting solution and medicinal residues;
(4) combining step (2) and step (3) extracting solution, is concentrated at 40 DEG C relative density and is the thick original text of 1.2, drying and crushing, and obtaining granularity is 100 order powder;
(5) Morchella esculenta (L.) Pers 58 parts is ground to 100 order powder, mix homogeneously with step (4) powder, load capsule, every 0.6g, to obtain final product.
Embodiment 3
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 18 parts, Radix Rehmanniae Preparata 128 parts, Fructus Corni (system) 65 parts, the Cortex Eucommiae 26 parts, Herba Cistanches 15 parts, Rhizoma Alismatis 36 parts, Semen Euryales 27 parts, Rhizoma Zingiberis Preparatum 24 parts, Radix Angelicae Sinensis 21 parts and Morchella esculenta (L.) Pers 62 parts.
The preparation method of the Chinese medicine composition of above-mentioned warming and recuperating the kidney-YANG, comprises the following steps:
(1) crude drug of above-mentioned parts by weight is prepared: Cortex Cinnamomi 18 parts, Radix Rehmanniae Preparata 128 parts, Fructus Corni (system) 65 parts, the Cortex Eucommiae 26 parts, Herba Cistanches 15 parts, Rhizoma Alismatis 36 parts, Semen Euryales 27 parts, Rhizoma Zingiberis Preparatum 24 parts, Radix Angelicae Sinensis 21 parts and Morchella esculenta (L.) Pers 62 parts;
(2) step (1) powder is adopted 7 times amount soak with ethanol 1.0h, supersound extraction 3 times, each 20min, supersonic frequency 20kHz, power 300W, filters, is concentrated into without alcohol taste, obtains extracting solution and medicinal residues;
(3) by step (2) medicinal residues add the distilled water of 8 times of weight, it is heated to reflux 2 times, each 4h, obtains extracting solution and medicinal residues;
(4) combining step (2) and step (3) extracting solution, is concentrated at 50 DEG C relative density and is the thick original text of 1.42, drying and crushing, and obtaining granularity is 120 order powder;
(5) Morchella esculenta (L.) Pers 62 parts is ground to 100 order powder, mix homogeneously with step (4) powder, load capsule, every 1.0g, to obtain final product.
Embodiment 4
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 20 parts, Radix Rehmanniae Preparata 130 parts, Fructus Corni (system) 60 parts, the Cortex Eucommiae 30 parts, Herba Cistanches 15 parts, Rhizoma Alismatis 40 parts, Semen Euryales 30 parts, Rhizoma Zingiberis Preparatum 25 parts, Radix Angelicae Sinensis 21 parts and Morchella esculenta (L.) Pers 70 parts.
The preparation method of the Chinese medicine composition of above-mentioned warming and recuperating the kidney-YANG, comprises the following steps:
(1) crude drug of above-mentioned parts by weight is prepared: Cortex Cinnamomi 20 parts, Radix Rehmanniae Preparata 130 parts, Fructus Corni (system) 60 parts, the Cortex Eucommiae 30 parts, Herba Cistanches 15 parts, Rhizoma Alismatis 40 parts, Semen Euryales 30 parts, Rhizoma Zingiberis Preparatum 25 parts and Radix Angelicae Sinensis 21 parts;
(2) step (1) powder is adopted 8 times amount soak with ethanol 1.0h, supersound extraction 3 times, each 30min, supersonic frequency 20kHz, power 500W, filters, is concentrated into without alcohol taste, obtains extracting solution and medicinal residues;
(3) by step (2) medicinal residues add the distilled water of 10 times of weight, it is heated to reflux 4 times, each 3h, obtains extracting solution and medicinal residues;
(4) combining step (2) and step (3) extracting solution, is concentrated at 30 DEG C relative density and is the thick original text of 1.3, drying and crushing, and obtaining granularity is 100 order powder;
(5) Morchella esculenta (L.) Pers 70 parts is ground to 80 order powder, mix homogeneously with step (4) powder, load capsule, every 0.6g, to obtain final product.
Embodiment 5
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 20 parts, Radix Rehmanniae Preparata 130 parts, Fructus Corni (system) 70 parts, the Cortex Eucommiae 30 parts, Herba Cistanches 15 parts, Rhizoma Alismatis 40 parts, Semen Euryales 30 parts, Rhizoma Zingiberis Preparatum 25 parts, Radix Angelicae Sinensis 21 parts, Morchella esculenta (L.) Pers 70 parts, Fructus Psoraleae 10 parts and Semen Cuscutae 10 parts.
The preparation method of the Chinese medicine composition of above-mentioned warming and recuperating the kidney-YANG, comprises the following steps:
(1) crude drug of above-mentioned parts by weight is prepared: Cortex Cinnamomi 20 parts, Radix Rehmanniae Preparata 130 parts, Fructus Corni (system) 70 parts, the Cortex Eucommiae 30 parts, Herba Cistanches 15 parts, Rhizoma Alismatis 40 parts, Semen Euryales 30 parts, Rhizoma Zingiberis Preparatum 25 parts, Radix Angelicae Sinensis 21 parts, Fructus Psoraleae 10 parts and Semen Cuscutae 10 parts;
(2) step (1) powder is adopted 10 times amount soak with ethanol 0.8h, supersound extraction 3 times, each 30min, supersonic frequency 20kHz, power 500W, filters, is concentrated into without alcohol taste, obtains extracting solution and medicinal residues;
(3) by step (2) medicinal residues add the distilled water of 10 times of weight, it is heated to reflux 4 times, each 3h, obtains extracting solution and medicinal residues;
(4) combining step (2) and step (3) extracting solution, is concentrated at 30 DEG C relative density and is the thick original text of 1.37, drying and crushing, and obtaining granularity is 100 order powder;
(5) Morchella esculenta (L.) Pers 70 parts is ground to 80 order powder, mix homogeneously with step (4) powder, load capsule, every 0.7g, to obtain final product.
Embodiment 6
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 21 parts, Radix Rehmanniae Preparata 138 parts, Fructus Corni (system) 75 parts, the Cortex Eucommiae 35 parts, Herba Cistanches 18 parts, Rhizoma Alismatis 42 parts, Semen Euryales 33 parts, Rhizoma Zingiberis Preparatum 27 parts, Radix Angelicae Sinensis 25 parts and Morchella esculenta (L.) Pers 71 parts.
The preparation method of the Chinese medicine composition of above-mentioned warming and recuperating the kidney-YANG, comprises the following steps:
(1) crude drug of above-mentioned parts by weight is prepared: Cortex Cinnamomi 21 parts, Radix Rehmanniae Preparata 138 parts, Fructus Corni (system) 75 parts, the Cortex Eucommiae 35 parts, Herba Cistanches 18 parts, Rhizoma Alismatis 42 parts, Semen Euryales 33 parts, Rhizoma Zingiberis Preparatum 27 parts and Radix Angelicae Sinensis 25 parts;
(2) step (1) powder is adopted 9 times amount soak with ethanol 1.0h, supersound extraction 3 times, each 30min, supersonic frequency 25kHz, power 500W, filters, is concentrated into without alcohol taste, obtains extracting solution and medicinal residues;
(3) by step (2) medicinal residues add the distilled water of 8 times of weight, it is heated to reflux 3 times, each 2h, obtains extracting solution and medicinal residues;
(4) combining step (2) and step (3) extracting solution, is concentrated at 50 DEG C relative density and is the thick original text of 1.45, drying and crushing, and obtaining granularity is 120 order powder;
(5) Morchella esculenta (L.) Pers 71 parts is ground to 120 order powder, mix homogeneously with step (4) powder, load capsule, every 0.8g, to obtain final product.
Embodiment 7
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 21 parts, Radix Rehmanniae Preparata 138 parts, Fructus Corni (system) 75 parts, the Cortex Eucommiae 35 parts, Herba Cistanches 18 parts, Rhizoma Alismatis 42 parts, Semen Euryales 33 parts, Rhizoma Zingiberis Preparatum 27 parts, Radix Angelicae Sinensis 25 parts, Morchella esculenta (L.) Pers 71 parts, Fructus Psoraleae 6 parts and Semen Cuscutae 8 parts.
The preparation method of the Chinese medicine composition of above-mentioned warming and recuperating the kidney-YANG, comprises the following steps:
(1) crude drug of above-mentioned parts by weight is prepared: Cortex Cinnamomi 21 parts, Radix Rehmanniae Preparata 138 parts, Fructus Corni (system) 75 parts, the Cortex Eucommiae 35 parts, Herba Cistanches 18 parts, Rhizoma Alismatis 42 parts, Semen Euryales 33 parts, Rhizoma Zingiberis Preparatum 27 parts, Radix Angelicae Sinensis 25 parts, Fructus Psoraleae 6 parts and Semen Cuscutae 8 parts;
(2) step (1) powder is adopted 10 times amount soak with ethanol 0.5h, supersound extraction 3 times, each 30min, supersonic frequency 25kHz, power 500W, filters, is concentrated into without alcohol taste, obtains extracting solution and medicinal residues;
(3) by step (2) medicinal residues add the distilled water of 9 times of weight, it is heated to reflux 4 times, each 2h, obtains extracting solution and medicinal residues;
(4) combining step (2) and step (3) extracting solution, is concentrated at 50 DEG C relative density and is the thick original text of 1.5, drying and crushing, and obtaining granularity is 100 order powder;
(5) Morchella esculenta (L.) Pers 71 parts is ground to 100 order powder, mix homogeneously with step (4) powder, load capsule, every 1.0g, to obtain final product.
Embodiment 8
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 23 parts, Radix Rehmanniae Preparata 145 parts, Fructus Corni (system) 80 parts, the Cortex Eucommiae 37 parts, Herba Cistanches 20 parts, Rhizoma Alismatis 43 parts, Semen Euryales 37 parts, Rhizoma Zingiberis Preparatum 30 parts, Radix Angelicae Sinensis 26 parts and Morchella esculenta (L.) Pers 75 parts.
The Chinese medicine composition preparation method of the present embodiment warming and recuperating the kidney-YANG is shown in embodiment 2.
Embodiment 9
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 24 parts, Radix Rehmanniae Preparata 150 parts, Fructus Corni (system) 83 parts, the Cortex Eucommiae 39 parts, Herba Cistanches 21 parts, Rhizoma Alismatis 45 parts, Semen Euryales 40 parts, Rhizoma Zingiberis Preparatum 35 parts, Radix Angelicae Sinensis 28 parts and Morchella esculenta (L.) Pers 80 parts.
The Chinese medicine composition preparation method of the present embodiment warming and recuperating the kidney-YANG is shown in embodiment 3.
Embodiment 10
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 25 parts, Radix Rehmanniae Preparata 156 parts, Fructus Corni (system) 85 parts, the Cortex Eucommiae 40 parts, Herba Cistanches 23 parts, Rhizoma Alismatis 45 parts, Semen Euryales 42 parts, Rhizoma Zingiberis Preparatum 37 parts, Radix Angelicae Sinensis 29 parts, Morchella esculenta (L.) Pers 77 parts, Fructus Psoraleae 9 parts and Semen Cuscutae 6 parts and Rhizoma Dioscoreae 25 parts.
Rhizoma Dioscoreae, sweet, flat, return spleen, lung, kidney channel; Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission, and for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst. Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating, for insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia. Rhizoma Dioscoreae adds in Traditional Chinese medicine composition formula of the present invention, coordinating the actions of various ingredients in a prescription, spleen reinforcing stomach invigorating, and the resistance of enhancing body promotes that each crude drug absorbs.
The preparation method of the Chinese medicine composition of above-mentioned warming and recuperating the kidney-YANG, comprises the following steps:
(1) crude drug of above-mentioned parts by weight is prepared: Cortex Cinnamomi 25 parts, Radix Rehmanniae Preparata 156 parts, Fructus Corni (system) 85 parts, the Cortex Eucommiae 40 parts, Herba Cistanches 23 parts, Rhizoma Alismatis 45 parts, Semen Euryales 42 parts, Rhizoma Zingiberis Preparatum 37 parts, Radix Angelicae Sinensis 29 parts, Fructus Psoraleae 9 parts, Semen Cuscutae 6 parts and Rhizoma Dioscoreae 25 parts;
(2) step (1) powder is adopted 10 times amount soak with ethanol 0.5h, supersound extraction 3 times, each 30min, supersonic frequency 25kHz, power 500W, filters, is concentrated into without alcohol taste, obtains extracting solution and medicinal residues;
(3) by step (2) medicinal residues add the distilled water of 10 times of weight, it is heated to reflux 4 times, each 3h, obtains extracting solution and medicinal residues;
(4) combining step (2) and step (3) extracting solution, is concentrated at 50 DEG C relative density and is the thick original text of 1.39, drying and crushing, and obtaining granularity is 120 order powder;
(5) Morchella esculenta (L.) Pers 77 parts is ground to 120 order powder, mix homogeneously with step (4) powder, load capsule, every 1.0g, to obtain final product.
Embodiment 11
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 25 parts, Radix Rehmanniae Preparata 156 parts, Fructus Corni (system) 85 parts, the Cortex Eucommiae 40 parts, Herba Cistanches 23 parts, Rhizoma Alismatis 45 parts, Semen Euryales 42 parts, Rhizoma Zingiberis Preparatum 37 parts, Radix Angelicae Sinensis 29 parts and Morchella esculenta (L.) Pers 77 parts.
The Chinese medicine composition preparation method of the present embodiment warming and recuperating the kidney-YANG is shown in embodiment 4.
Embodiment 12
The Chinese medicine composition of a kind of warming and recuperating the kidney-YANG, including the crude drug of following parts by weight: Cortex Cinnamomi 25 parts, Radix Rehmanniae Preparata 160 parts, Fructus Corni (system) 90 parts, the Cortex Eucommiae 40 parts, Herba Cistanches 25 parts, Rhizoma Alismatis 46 parts, Semen Euryales 45 parts, Rhizoma Zingiberis Preparatum 40 parts, Radix Angelicae Sinensis 30 parts and Morchella esculenta (L.) Pers 80 parts.
The Chinese medicine composition preparation method of the present embodiment warming and recuperating the kidney-YANG is shown in embodiment 6.
Clinical case
1, clinical data
1.1 patient data
Treatment group 205 example insufficiency of kidney-YANG patient, wherein male 113 example, women 92 example, matched group 190 example insufficiency of kidney-YANG patient, wherein male 98 examples, female 92 example.
1.2 diagnostic criterias
" guideline of clinical investigations of new Chinese medicine treatment insufficiency of kidney-YANG " promulgated with reference to Ministry of Public Health is diagnostic criteria, primary symptom: soreness of waist and knee joint, aversion to cold and cold limbs, hyposexuality, and body of the tongue is fat greatly, and tongue is white, deep pulse; Secondary disease: lassitude, nocturia, edema of lower limbs, breathe hard and breathe heavily, big loose stool, alopecia.
Curative effect determinate standard:
Clinical recovery: the symptom of insufficiency of kidney-YANG, sign disappears;
Effective: the symptom of insufficiency of kidney-YANG, sign are obviously improved;
Effective: the symptom of insufficiency of kidney-YANG, sign all take a favorable turn;
Invalid: the symptom of insufficiency of kidney-YANG, sign is without improvement.
1.3 Excluded cases standards
(1) have and substantially hold concurrently folder card or merge card person;
(2) age is under-18s over-65s, gestation or women breast-feeding their children, allergic constitution and those who are allergic to this drug;
(3) the severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney, hemopoietic system, psychotic it are associated with;
(4) not meeting inclusive criteria, not by regulation medication, it is impossible to judge curative effect, or data is not congruent affects the treatment or safety judgement person.
2, Therapeutic Method
The capsule of the oral embodiment of the present invention 6 for the treatment of group, every 0.8g, every day 2-3 time, each 4-5 grain; Matched group is administered orally JISHENG SHENQI WAN, every ball 9g, every day 2-3 time, each 1 ball.
3, clinical test results is in Table 1.
Table 1 clinical test results
Two groups of obvious effective rate comparitive study, P < 0.05, there is significant difference, it was shown that the Chinese medicine composition curative effect of warming and recuperating the kidney-YANG of the present invention is better than conventional treatments.
Model case
Zhao so-and-so, man, 42 years old, people from Zhengzhou City Henan Province, patient's soreness of the waist and knees, aversion to cold and cold limbs, nocturia, libido reduce. Carry out the treatment of this place upon somebody's introduction, diagnose and be: insufficiency of kidney-YANG. Taking the embodiment of the present invention 1 capsule, every 0.8g, every day 3 times, each 4, take 2 courses for the treatment of, symptom, sign alleviate, and continue to take 2 courses for the treatment of, and symptom, sign are wholly absent, and cure, follow up a case by regular visits to and do not recur half a year.
Korea Spro, man, 33 years old, people from Nanyang City, Henan Province, patient's soreness of the waist and knees and pain, sexual impotence, cold sperm, stool chronic diarrhea was more than, clear urine in large amounts or frequent urination at night, the fat white, slippery and moist fur of light red tongue, deep-slow pulse, comes this place upon somebody's introduction and treats, and diagnoses and is: insufficiency of kidney-YANG. Taking the embodiment of the present invention 6 capsule, every 0.8g, every day 3 times, each 5, take 3 courses for the treatment of, the soreness of waist, cold extremities symptom alleviate, and continue to take 2 courses for the treatment of, and symptom, sign are wholly absent, and cure, follow up a case by regular visits to and do not recur half a year.
Lee, female, 36 years old, people from Nanyang City, Henan Province, patient's vertigo, lethargy, nocturia, insomnia and dreamful sleep, foot, lower limb edema. Carry out the treatment of this place upon somebody's introduction, diagnose and be: insufficiency of kidney-YANG. Taking the embodiment of the present invention 5 capsule, every 0.7g, every day 3 times, each 5, take 2 courses for the treatment of, the symptom such as edema is eased, and continues to take 3 courses for the treatment of, and symptom, sign all disappear, and cures, follows up a case by regular visits to and do not recur so far.
King so-and-so, female, 28 years old, people from Xixia, Henan, patient back swelling and pain, time such as bore spine limb swelling, numbness, walk with difficulty, get Re Zeshu, light red tongue, white and thin fur, thready and moderate pulse.Carry out the treatment of this place upon somebody's introduction, diagnose and be: insufficiency of kidney-YANG. Taking the embodiment of the present invention 4 capsule, every 0.6g, every day 3 times, each 5, take 2 courses for the treatment of, the soreness of waist, cold extremities symptom alleviate, and continue to take 3 courses for the treatment of, and symptom, sign are wholly absent, and cure, follow up a case by regular visits to and do not recur half a year.
Claims (7)
1. the Chinese medicine composition of a warming and recuperating the kidney-YANG, it is characterized in that, including the crude drug of following parts by weight: Cortex Cinnamomi 15-25 part, Radix Rehmanniae Preparata 120-160 part, Fructus Corni (system) 60-90 part, Cortex Eucommiae 20-40 part, Herba Cistanches 11-25 part, Rhizoma Alismatis 30-46 part, Semen Euryales 20-45 part, Rhizoma Zingiberis Preparatum 20-40 part, Radix Angelicae Sinensis 18-30 part and Morchella esculenta (L.) Pers 50-80 part.
2. the Chinese medicine composition of warming and recuperating the kidney-YANG according to claim 1, it is characterized in that, including the crude drug of following parts by weight: Cortex Cinnamomi 20-24 part, Radix Rehmanniae Preparata 130-150 part, Fructus Corni (system) 60-83 part, Cortex Eucommiae 30-39 part, Herba Cistanches 15-21 part, Rhizoma Alismatis 40-45 part, Semen Euryales 30-40 part, Rhizoma Zingiberis Preparatum 25-35 part, Radix Angelicae Sinensis 21-28 part and Morchella esculenta (L.) Pers 70-80 part.
3. the Chinese medicine composition of warming and recuperating the kidney-YANG according to claim 2, it is characterized in that, including the crude drug of following parts by weight: Cortex Cinnamomi 21 parts, Radix Rehmanniae Preparata 138 parts, Fructus Corni (system) 75 parts, the Cortex Eucommiae 35 parts, Herba Cistanches 18 parts, Rhizoma Alismatis 42 parts, Semen Euryales 33 parts, Rhizoma Zingiberis Preparatum 27 parts, Radix Angelicae Sinensis 25 parts and Morchella esculenta (L.) Pers 71 parts.
4. the Chinese medicine composition of warming and recuperating the kidney-YANG according to claim 1, it is characterised in that also include Fructus Psoraleae 6-15 part and Semen Cuscutae 6-15 part.
5. the preparation method of the Chinese medicine composition of the warming and recuperating the kidney-YANG described in a claim 1, it is characterised in that comprise the following steps:
(1) raw material of following parts by weight is prepared: Cortex Cinnamomi 15-25 part, Radix Rehmanniae Preparata 120-160 part, Fructus Corni (system) 60-90 part, Cortex Eucommiae 20-40 part, Herba Cistanches 11-25 part, Rhizoma Alismatis 30-46 part, Semen Euryales 20-45 part, Rhizoma Zingiberis Preparatum 20-40 part and Radix Angelicae Sinensis 18-30 part, dry, pulverize to powder;
(2) step (1) powder is adopted 5-10 times amount soak with ethanol 0.5-1.0h, supersound extraction 2-3 time, each 20-30min, filter, be concentrated into without alcohol taste, obtain extracting solution and medicinal residues;
(3) by step (2) medicinal residues add the distilled water of 5-10 times of weight, it is heated to reflux 2-4 time, each 2-4h, obtains extracting solution and medicinal residues;
(4) combining step (2) and step (3) extracting solution, at being concentrated into 30-50 DEG C, relative density is the thick original text of 1.2-1.5, and drying and crushing obtains powder;
(5) Morchella esculenta (L.) Pers 50-80 part is ground to powder, mix homogeneously with step (4) powder, to obtain final product.
6. the preparation method of the Chinese medicine composition of warming and recuperating the kidney-YANG according to claim 5, it is characterised in that the supersonic frequency 15-25kHz described in step (2), power 300-500W.
7. the preparation method of the Chinese medicine composition of warming and recuperating the kidney-YANG according to claim 5, it is characterised in that the granularity of step (4) and the powder described in step (5) is 80-120 order.
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