CN104800780A - Traditional Chinese medicine preparation for treating polycystic ovarian syndrome and preparation method of traditional Chinese medicine preparation - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating polycystic ovarian syndrome. The traditional Chinese medicine preparation is prepared by the following raw materials in a given weight ratio: rhizoma atractylodis, rhizoma cyperi, peony bark, dried orange peel, pinellia ternate, Tuckahoe, herba lycopi, arisaema cum bile, fruit of immature citron, rhizoma sparganii, curcuma zedoary, ground beetle, endothelium corneum gigeriae galli, silkworm excrement, Chinese yew, edible tulip, manis pentadactyla, hawthorn fruits, medicinal cyathula root, spina gleditsiae, seed of Chinese dodder, semen plantaginis, glossy privet fruits, radix scrophulariae, repared rehmannia root, verbena, leonurus japonicas and dianthus superbus. The traditional Chinese medicine preparation has functions for relieving and eliminating mass, removing stasis, promoting the blood circulation, dispersing blood stasis, strengthening the spleen and quieting the heart and can effectively treat the polycystic ovarian syndrome.

Description

A kind of Chinese medicine preparation for the treatment of polycystic ovarian syndrome and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of polycystic ovarian syndrome, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Polycystic ovarian syndrome is a kind of reproductive dysfunction and abnormal carbohydrate metabolism and the endocrine regulation syndrome of depositing.Chronic anovulation, many follicles are immature, Hyperandrogenism and insulin resistant are its key characters, are the modal reasons of women at fertile age menoxenia.Have menoxenia, amenorrhea, anovulation, hirsutism, fat, infertile and bilateral ovaries increases in Cystic changes, is called polycystic ovary syndrome.Patient can possess above classical symptom, also can only have partial symptoms, but causes infertile because of ovulation failure, is the main clinical manifestation of polycystic ovarian syndrome.The clinical manifestation weight of polycystic ovarian syndrome differs, multiple be born in 20-40 year period of duration women, typical patients with polycystic ovary syndrome main manifestations is the following aspects: 1, infrequent menstruation is so that amenorrhea; 2, infertile; 3, fat: about half patient has this to show, hair increases, thick and black, some hairs are distributed with manlike tendency, and some patients still has acne; 4, bilateral ovaries increases: the body can being determined ovary by peritoneoscope direct-view ovary or B ultrasonic video picture inspection; 5, many follicles are immature, and in whole menstrual phase, B ultrasonic video picture inspection has most immature follicles.

At present for this disease, what doctor trained in Western medicine adopted is " trilogy " therapy, the first stage: make wedge excision to the ovary of cystic hyperplasia; Second stage: Drug therapy, such as clomiphene, HMG, GnRH, fruit receive sweet smell, Marvelon, reach English etc., but, As time goes on, its low pregnancy rate, the shortcoming of high abortion ratio comes out gradually; Phase III: puncture to dull follicle under ultrasound guidance or peritoneoscope, these therapies may cause damage to ovary, or cause pelvic adhesion and have potential harm to fetus.But because of the fraud of its moving knife of cutting open the belly, to be destined to replace by non-operative treatment.The present traditional Chinese medical science, because of the advantage of its " do not need operation, risk is little, and treating both the principal and secondary aspects of a disease ", is subject to the favor of extensive patients day by day.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation, this Chinese medicine preparation has determined curative effect for treatment polycystic ovarian syndrome, and side effect is little, taking convenience, does not operate on, do not stay the feature of scar.

Another object of the present invention is to provide the preparation method of this Chinese medicine preparation.

Inventor is in clinical treatment practice for many years, observe the misery that polycystic ovarian syndrome brings to patient, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of polycystic ovarian syndrome repeatedly, the present invention selects Rhizoma Atractylodis, Rhizoma Cyperi, Cortex Moutan, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Herba Lycopi, Arisaema Cum Bile, Fructus Aurantii Immaturus, Rhizoma Sparganii, Rhizoma Curcumae, Eupolyphaga Seu Steleophaga, Endothelium Corneum Gigeriae Galli, Bombyx mori L., Ramulus et folium taxi cuspidatae, Pseudobulbus Cremastrae Seu Pleiones, Squama Manis, Fructus Crataegi, Radix Cyathulae, Spina Gleditsiae, Semen Cuscutae, Semen Plantaginis, Fructus Ligustri Lucidi, Radix Scrophulariae, Radix Rehmanniae Preparata, Herba Verbenae, Herba Leonuri, Herba Dianthi combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is dissolving lump and resolving mass, promoting QI circulation for relieving depression, blood circulation promoting and blood stasis dispelling, effect of spleen invigorating mind calming, thus effectively can treat polycystic ovarian syndrome.

The effect of Chinese medicine of the present invention:

Wherein:

Rhizoma Atractylodis: be the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodes lancea (Thunb.) DC. or Atractylis chinensis Atractylodes chinensis (DC.) Koidz..Nature and flavor: pungent, bitter, temperature; Return spleen, stomach, Liver Channel; Effect: drying damp and strengthening spleen, expelling wind and cold, improving eyesight; This product toil is warm in nature, and virtue is strong dry loose, and can rise and can fall, walk and do not keep, can be that damp is removed and recovers the transportation capabilities of spleen.

Rhizoma Cyperi: be the dry rhizome of sedge dried tuber Cyperus rotundus L..Nature and flavor: pungent, micro-hardship, micro-sweet are flat.Return liver, spleen, tri-jiao channel.Effect: promoting QI circulation for relieving depression, menstruction regulating and pain relieving, antiabortive, regulate the flow of vital energy Shu Yu, harmonizing the liver and stomach.The pungent loose hardship of this product is let out, and is the key medicine of depressed liver-energy dispersing and QI regulating, can be used for all pain cards caused by irritability stasis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": adjust the gas in blood, dissipating depression of QI, alleviating distention in middle-JIAO, helps digestion." book on Chinese herbal medicine is looked for the truth ": Rhizoma Cyperi, exclusive dissipating depression of QI falls apart gas, and with Radix Aucklandiae circulation of qi promoting, looks are with real different, and Radix Aucklandiae abnormal smells from the patient hardship is bad, therefore ventilation is very prompt, and this is then bitter and not very, therefore resolving depression is in the majority, and property and in the Radix Aucklandiae, therefore can add and subtract discrepancy, thinks circulation of qi promoting obstruction-removing prescription, otherwise should this and those ears unsuitable.

Cortex Moutan: the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor: bitter, cool.GUIXIN, liver, kidney, lung meridian.Effect: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.The power of Cortex Moutan removing heat from blood is comparatively strong, and can purify the blood a point excess-heat, can control fever due to yin deficiency again, this product cold nature, energy clearing heat in YING system divides, blood system excess-heat, has the merit of cooling blood for hemostasis, and Cortex Moutan is pungent cold, is apt to into blood system, can removing heat from blood with hemostasis, can invigorate blood circulation with dissipating blood stasis again, the kind logical heat in blood stasis of blood is stagnant.

Pericarpium Citri Reticulatae: be the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Nature and flavor: temperature are pungent, bitter.Enter spleen, stomach, lung meridian.Effect: regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.This product temperature can circulation of qi promoting, pungently can disperse, bitter and sluice.Pericarpium Citri Reticulatae and the same use of Fructus Aurantii Immaturus, acrid in the mouth circulation of qi promoting, fragrance enters spleen, therefore can promoting the circulation of QI to relieve pain, spleen invigorating and in, Pericarpium Citri Reticulatae and the Rhizoma Pinelliae can drying dampness to eliminate phlegm with use, again can warming for resolving cold-phlegm.

The Rhizoma Pinelliae: be the tuber at the Rhizoma Arisaematis section plant Rhizoma Pinelliae (Pinellia ternata (Thunb.) Breit.).Nature and flavor: pungent, temperature, poisonous.Enter spleen, stomach warp.Effect: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.The pungent loose warm-dryness syndrome of these product is poisonous, main enter taste double enter lung, water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.Both cure mainly the abundant expectoration cough with asthma QI rising in reverse order of spleen damp-phlegm heap soil or fertilizer over and around the roots, control again the dizzy palpitation and insomnia that damp-phlegm is violated." property of medicine opinion ": expectorant saliva, appetite promoting and the spleen strengthening, anti-nausea, go expectorant in the heart full, lower lung qi, master coughs knot.New survivor rub be coated with carbuncle do not disappear, can tumor wart be removed.

Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, is the key medicine of promoting diuresis to eliminate damp pathogen.Treatment water wet the edema of expert time, often join Rhizoma Alismatis, Polyporus.Poria decoct has obvious sedation." modality ": " cure mainly Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side." this product is by heart-spleen boosting and tranquilizing mind.Be used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.

Herba Lycopi: be the dry aerial parts of labiate hair leaf lycopus lucidus Lycopus lucidus Turcz. var.hirtus Regel.Nature and flavor: bitter, pungent, tepor.Return liver, spleen channel.Effect: blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema." Bencao Jingshu ": Herba Lycopi, hardship can expel the heat-evil, sweet energy and blood, and acid can enter liver, the logical nutrient blood of temperature.Assistant with the medicine of strengthening the spleen soil, and makes with Radix Stephaniae Tetrandrae, then main extensive abdominal edema, body face extremity edema, aqueous vapor in joint for it.

Arisaema Cum Bile: for the fine powder of Rhizoma Arisaematis (processed) and cattle, sheep or Fel Sus domestica process from strand, or form through fermentation processing for Arisaema Cum Bile fine powder and cattle, sheep or Fel Sus domestica.Nature and flavor: bitter, cold, micro-pungent, cool.Return lung, liver, spleen channel.Effect: removing heat-phlegm, dispelling wind and relieving convulsion.This product can control middle wind-phlegm fan, infantile convulsion epilepsy, and phlegm-fire is breathed heavily and coughed, phlegm-accumulating vertigo.Record in " medicineization justice ": " cure mainly all apoplexy, acute infantile convulsion, infantile convulsion, wind syndrome of head, dizzy, old god is slow-witted, and children's sends out and jerks, puerperal severe palpitation." " book on Chinese herbal medicine converge with speech ": Rhizoma Arisaematis, forefathers with Fel Bovis seu Bubali system it, name says Arisaema Cum Bile.Fel Bovis seu Bubali bitter cold and moistening, has the merit that the liver benefiting is relieving convulsion, star processed dry and make not malicious.

Fructus Aurantii Immaturus: be the dry young fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety or Fructus Citri sinensis Citrus sinensis Osbeck.Nature and flavor: bitter, acrid, cold.Return spleen, stomach, liver, heart channel.Effect: dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Cure mainly: weight, blocked-up chest, gastroptosis, uterine prolapse, proctoptosis after feeling of fullness distending pain, constipation, dysentery.Neohesperidin in Fructus Aurantii Immaturus, naringin have anti-inflammatory effect, have with the paeoniflorin in Radix Paeoniae the effect be multiplied.Furctus Aurantii Immaturus extract has obvious sedation.This product also can be used for the diseases such as gastroptosis, proctoptosis, uterine prolapse, should with the product of the raw sun of QI invigorating with using; This product has boosting again, can be used for shock.

Rhizoma Sparganii: be the dry tuber of Sparganiaceae plant Rhizoma Sparganii Spaganium stoloniferum Buch.-Ham..Nature and flavor: pungent, puckery, cool.Enter liver, spleen channel.Effect: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Lump in the abdomen controlled by Chinese medicine, gathers, distending pain over the hypochondrium, food stagnation distending pain, dysmenorrhea, amenorrhea, and postnatal blood stasis is suffered from abdominal pain, traumatic injury.Pharmaceutical research: Rhizoma Sparganii has anticoagulant, extends thrombus formation time, shortens thrombosis, the effect of length and weight reduction, also has the trend extending prothrombin time and part Thrombokinase, reduces whole blood viscosity.

Rhizoma Curcumae: be monocotyledon Zingiberaceae Zingiberaceae Rhizoma Curcumae Curcuma phaeocaulis Val., or RADIX CURCUMAE (also known as Curcuma wenyujin) C. wenyujin Y. H. Chen et C. Ling, the dry rhizome of Guangxi zedoary (also known as C. kwangsinensis) C.kwangsiensis S. lee et C. F. Liang.Nature and flavor: pungent, bitter, temperature.Return liver, spleen channel.Effect: removing blood stasis, promoting the circulation of QI to relieve pain.Often join Rhizoma Sparganii.Antibacterial action: Rhizoma Curcumae volatile oil in vitro can suppress staphylococcus aureus.The growth of beta hemolytic streptococcus, escherichia coli, Bacillus typhi, vibrio cholera etc.Rhizoma Curcumae has the effect of directly killing oncocyte.Pharmaceutical research, Rhizoma Curcumae has certain effect to cardiovascular, and it is the most obvious that Rhizoma Curcumae increases acting in drug for invigorating blood circulation and eliminating stasis of femoral artery blood flow, and Rhizoma Curcumae also has suppression platelet aggregation and antithrombotic effect.

Eupolyphaga Seu Steleophaga: for the female worm of Corydiidae insecticide eupolyphoge sinensis Eupolyphaga sinensis Walker or Ji eupolyphoge sinensis Stelephaga plancyi (Boleny) is all.Nature and flavor: cold, salty; Slightly poisonous.Return Liver Channel.Effect: removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones, is used for the treatment of traumatic injury, and the injury of tendon and muscle is fractured, pain caused by ecchymoma.This product salty-cold enter blood, main enter Liver Channel, property is apt to away alter, can promoting blood circulation and detumescence pain relieving, and reunion of fractured tendons and bones is cured the wound, and is traumatology common medicine, is especially used for the injury of tendon and muscle of fracturing, swelling and pain due to blood stasis.

Endothelium Corneum Gigeriae Galli: be the dry inner wall of sandbag of Phasianidae animal man chicken Gallus gallus domesticus Brisson.Nature and flavor: sweet are flat.Return spleen, stomach, small intestinal, urinary bladder channel.Effect: invigorating the stomach and promoting digestion, arresting seminal emission.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission." Bencao Jingshu ": gizzard is the spleen of chicken is the institute of digesting and absorbing the essence of foodstuff of disappearing.The sensible large intestine of its gas, bladder two warp.There is heat then to let out dysentery incontinence of urine, the gas that must be slightly cold then evanescence of heat, and let out the spontaneous recovery of dysentery incontinence of urine.Tired give birth to because of heat, heat is gone therefore tired of stopping also.This life controls all chancre multiple-effect with it again.

Bombyx mori L.: be the dry feces of Bombycidae animal bombyx mori larva silkworm shit.Nature and flavor: sweet in the mouth; Pungent; Warm in nature.Return liver; Spleen; Stomach warp.Effect: expelling wind and removing dampness; Regulating the function of the stomach to resolve the turbidity; Promoting blood circulation to restore menstrual flow.Main air pain of dampness syndrome; Limbs are unsuccessful; Rubella pruritus; Vomit and diarrhoea and have a cramp; Amenorrhea; Metrorrhagia." book on Chinese herbal medicine is new again ": dispelling the wind and dampness pathogens is held back and lied prostrate in spleen man, and bones and muscles pain, skin is swelled, lumbago and skelalgia, blood stasis insufficiency of blood, and pox Ke Jiang Black-spot does not rise, and also should use it.

Ramulus et folium taxi cuspidatae: be taxaceae Ramulus et folium taxi cuspidatae Taxus cuspidata Sieb. et Zucc., dry branch and leaf.Nature and flavor: light; Property is put down.Return kidney channel.Effect: inducing diuresis to remove edema.Main nephritis edema; Dysuria; Diabetes.

Pseudobulbus Cremastrae Seu Pleiones: be the dry pseudobulb of orchid Cremastra appendiculata Cremastra appendiculata (D.Don) Makino, pleione bulbocodioides Pleione bulbocodioides (Franch.) Rolfe or Pleione yunnanensis Pleione yunnanensis Rolfe.Nature and flavor: sweet, pungent, cold, mild toxicity.Return liver, stomach, lung meridian.Effect: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.This product has the merit of detoxicating and resolving stagnation of pathogens detumescence, in recent years this product Guang general ground Yu mass in the abdomen mass in the abdomen and kinds of tumors.Normal and Bulbus Fritillariae Thunbergii, Spica Prunellae are used together.

Squama Manis: this product is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Nature and flavor: salty, be slightly cold.Return liver, stomach warp.Effect: stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.For Jing Bi WEIJIA, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.For amenorrhea due to stagnation of blood, lump in the abdomen lumps, the diseases such as rheumatic arthralgia, the contracture of muscle arteries and veins.Squama Manis is good at walking to alter, and property specially row is loose, can promoting blood circulation to remove blood stasis, current meridians, therefore availablely controls above-mentioned all kinds of disease.For carbuncle from the beginning of or the disease such as difficulty in discharging of pus.Squama Manis has effect of detumescence and apocenosis, and carbuncle can be made not become pus, and person disappears, and suppuration person's speed is burst, and normal being equal to Spina Gleditsiae, Olibanum, Myrrha, Flos Lonicerae is used clinically; Person as routed in carbuncle avoids use.

Fructus Crataegi: be the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge.var.major N.E.Br. or Fructus Crataegi Crataegus pinnatifida Bge..Nature and flavor: sour, sweet, tepor.Return spleen, stomach, Liver Channel.Effect: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.Modern pharmacological research shows: triterpenic acid contained in Fructus Crataegi can improve coronary circulation and that coronary artery sexual exhaustion is able to is compensatory, reaches cardiotonic.Fructus Crataegi can increase coronary flow in addition, reduces myocardial oxygen consumption, has protective effect to myocardial ischemia, anoxia.

Radix Cyathulae: be the dry root of amaranthaceous plant Radix Cyathulae Cyathula officinalis Kuan.Nature and flavor: sweet, micro-hardship, flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.

Spina Gleditsiae: be the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Nature and flavor: pungent, temperature.Return lung, Liver Channel.Effect: detumescence and apocenosis, promoting blood circulation by removing wind.Tcm clinical practice is used for swollen ulcer drug all good therapeutic effect, generally shows as the non-Cheng Zheke of pus and disappears, and formed pus person can make it speed and burst.Modern anticancer pharmacological research shows, Spina Gleditsiae has anticancer tumor-suppression activity.Modern pharmacology is studied its decoct flat board and to be burrowed method, has inhibitory action to staphylococcus aureus and micrococcus catarrhalis.It is up that Spina Gleditsiae can draw all medicines, the kind disease controlling the part of the body cavity above the diaphragm housing the heart and lungs.

Semen Cuscutae: be the dry mature seed of dicotyledon scammonia section plant Semen Cuscutae Cuscuta chinensis Lam..Nature and flavor: sweet, warm.Return liver, kidney channel.Effect: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs is with urine, antiabortive, improving eyesight, antidiarrheal.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.Semen Cuscutae gets final product YANG invigorating, again can tonifying YIN, has temperature and not dry, and the feature of tonify without causing stagnation is the good medicine of flat invigorating the liver and kidney.Often join Fructus Lycii, Fructus Schisandrae Chinensis etc.The effect of Endocrine: Semen Cuscutae can increase hypothalamic-pituitary-ovarian and urge luteal function.

Semen Plantaginis: be the dry mature seed of Plantaginaceae plant Herba Plantaginis Plantago asiatica L. or Plantago depressa Willd Plantago depressa Willd..Nature and flavor: sweet, are slightly cold.Return liver, kidney, lung, small intestine meridian.Effect: clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.

Fructus Ligustri Lucidi: be the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi Ligustrum lucidum Ait..Nature and flavor: bitter sweet, flat, nontoxic.Return liver, kidney, lung meridian.Effect: invigorating the liver and kidney, strong waist knee joint.Cure mainly: yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Modern pharmacology is studied: Fructus Ligustri Lucidi can enhancing non-specific immunity function, has dual regulation to the immunologic function of exception; Rising effect is had to the leukopenia caused by chemotherapy and radiation; The serum cholesterol of laboratory animal can be reduced, have prevention and cut down atheromatous plaque and the effect alleviating plaque thickness, coronary atherosclerosis number can be reduced and alleviate its degree of congestion; Obviously can reduce mda content in Mus brain at advanced age, liver, improve superoxide dismutase (SOD) active, the certain defying age using value of tool; There are heart tonifying, diuresis, blood sugar lowering and hepatoprotective effect; And have cough-relieving, cathartic, antibacterial, antitumor action.

Radix Scrophulariae: be the dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl..Nature and flavor: sweet, bitter, salty, are slightly cold.Return lung, stomach, kidney channel.Effect: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.There is slight hypoglycemic activity.To join the army for: warm febrile disease the card of blood, consumption of YIN caused by febrile disease.There is clearing away heat and cooling blood, effect of removing toxic substances YIN nourishing.Control warm febrile disease to join the army blood, impairment of YIN robs the fever of the body excessive thirst caused by liquid, uneasy sleeping at night, crimson tongue person, can share, as qingying decoction with the medicine such as the Radix Rehmanniae, Cornu rhinocerotis, Radix Salviae Miltiorrhizae; Control the high fever that warm febrile disease falls into pericardium, unconsciousness and delirium person, can share, as clearing heat in the pericardium soup with medicines such as Cornu rhinocerotis, golden bell core, Radix Ophiopogonis; Control epidemic febrile disease Gao Refa speckle person, can share, as Huaban Tang with medicines such as Gypsum Fibrosum, Cornu rhinocerotis, the Rhizoma Anemarrhenaes.

Radix Rehmanniae Preparata: be scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa(Gdertn) Iibosch.ex Fisch. et Mey.) tuber form through Processing methods.Nature and flavor: sweet, tepor.Return liver, kidney channel.Effect: nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.Radix Rehmanniae Preparata can be enriched blood YIN nourishing and liver-nourishing kidney-boosting, and all blood deficiency the moon loses, dizzy caused by deficiency of the liver and kindey, all can apply.

Herba Verbenae: be the dry aerial parts of Verbenaceae Herba Verbenae Verbena officinalis L..Nature and flavor: bitter, cool.Return liver, spleen channel.Effect: promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.For lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria." Bencao Jingshu ": Herba Verbenae is originally the medicine of removing heat from blood removing blood stasis.Bottom skin ulcer person, the pole of heat in blood, furthermore damp and hot, therefore blood stains are turbid forms skin ulcer, and have worm also.The cool pyrolysis of blood, the broken and row of dirty person, waste and be not recovered.CHEN Zang-Qi calls its removing blood stasis parasite killing, also this meaning ear.

Herba Leonuri: for Labiatae is annual or the herb of 2 years raw herbaceous plant Herba Leonuri Leonurus heterophyllus Sweet..Nature and flavor: bitter, pungent, are slightly cold.Return liver, pericardium channel.Effect: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.This product hardship is let out pungent loose, and master enters blood system, is good at blood circulation promoting and blood stasis dispelling regulating menstruation, flaccidity gynecological multiparity key medicine.

Herba Dianthi: this product is the dry aerial parts of Caryophyllaceae carnation Herba Dianthi Dianthus superbus L. or Dianthus chinensis Dianthus chinensis L..Nature and flavor: bitter, cold.GUIXIN, small intestine meridian.Effect: inducing diuresis for treating stranguria syndrome, removing blood stasis stimulates the menstrual flow.For pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, drenches the puckery pain of drop, menstruation apolipsis.This product still has the effect of promoting blood circulation to restore menstrual flow, can be used for the stagnant amenorrhea of the stasis of blood." Bencao Jingshu ": Herba Dianthi, bitter Lee can removing blood stasis, YIN-cold and falling, can tonneau lower orifices and row urine, therefore main obstruction and rejection please infirmity knot urinary obstruction because of in small intestinal heat notably.Tremble with fear and can dispel the heat, pungent energy eliminating stagnation, therefore carbuncle of determining.Except damp and hot, therefore improving eyesight removing nebula.Pungent cold removing blood stasis, the son therefore broken tire is fallen and under close blood also.Go kidney man heat, therefore cloud supports kidney qi.By the de-evil inverse person of wing, also let out damp and hot therefore also.Burnt in damp and hot visitor, then clear QI being mixed up with turbid QI and be cholera, tonneau is damp and hot, then cholera is explained by oneself.

Side's solution of the present invention is: in side, Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, Rhizoma Cyperi promoting QI circulation for relieving depression, menstruction regulating and pain relieving, Cortex Moutan clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, Rhizoma Pinelliae drying dampness to eliminate phlegm, dissolving lump and resolving mass, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, above Six-element is monarch drug altogether, first carry out dissolving lump and resolving mass from the health of patient, blood circulation promoting and blood stasis dispelling, remove the infrequent menstruation even clinical symptoms of amenorrhea that her ovaries's cyst is brought, and fundamentally can carry out the conditioning on health to patient, nourish the health of patient, promote patient body internal hormone balance, thus reach the object of disease therapy.Herba Lycopi's blood circulation promoting and blood stasis dispelling, Arisaema Cum Bile removing heat-phlegm, dispelling wind and relieving convulsion, Fructus Aurantii Immaturus reduces phlegm loose painful abdominal mass, Rhizoma Sparganii, Rhizoma Curcumae removing blood stasis, promoting the circulation of QI to relieve pain, Eupolyphaga Seu Steleophaga removing blood stasis with potent drugs blood, Endothelium Corneum Gigeriae Galli invigorating the stomach and promoting digestion, Bombyx mori L. promoting blood circulation to restore menstrual flow, above eight tastes are ministerial drug altogether, increase monarch drug dispersing the stagnated live-QI to relieve the stagnation of QI, while blood-activating and qi-promoting effect, also there is loose painful abdominal mass of reducing phlegm, effect of invigorating the stomach and promoting digestion, not only can treat the dizziness caused by patient's polycystic ovarian syndrome, insomnia, the symptoms such as obesity, can also fundamentally scholar to take care of health body, strengthening the body resistance, thus the health of patient is nursed one's health, reach the object of thoroughly radical cure.Ramulus et folium taxi cuspidatae inducing diuresis to remove edema, Pseudobulbus Cremastrae Seu Pleiones heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, Squama Manis detumescence and apocenosis, Fructus Crataegi promoting digestion and invigorating the stomach, Radix Cyathulae inducing diuresis for treating stranguria syndrome, Spina Gleditsiae detumescence and apocenosis, Semen Cuscutae nourishing the liver and kidney, Semen Plantaginis clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, Fructus Ligustri Lucidi invigorating the liver and kidney, Radix Scrophulariae clearing away heat and cooling blood, eliminating fire and detoxication, Radix Rehmanniae Preparata nourishing YIN and supplementing blood, beneficial essence fill out marrow, Herba Verbenae promoting blood circulation to remove blood stasis, Herba Leonuri promoting blood flow to regulate menstruation, inducing diuresis to remove edema, Herba Dianthi inducing diuresis for treating stranguria syndrome, removing blood stasis stimulates the menstrual flow.All tastes are adjuvant drug altogether above, while increasing drug effect, also have spleen invigorating mind calming, effect of enriching blood and promoting secretion of body fluid, alleviate patient's premenstrual molimen, accelerate the improvement of patient.All medicine compatibilities in side, the monarch and his subjects pull together, help and make auxiliary altogether, make it the effect with dissolving lump and resolving mass, promoting QI circulation for relieving depression, blood circulation promoting and blood stasis dispelling, spleen invigorating mind calming, can effectively treat women's polycystic ovarian syndrome.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Rhizoma Atractylodis 10-20 part, Rhizoma Cyperi 7-17 part, Cortex Moutan 10-20 part, Pericarpium Citri Reticulatae 7-17 part, Rhizoma Pinelliae 4-14 part, Poria 10-20 part, Herba Lycopi 7-17 part, Arisaema Cum Bile 4-14 part, Fructus Aurantii Immaturus 7-17 part, Rhizoma Sparganii 7-17 part, Rhizoma Curcumae 7-17 part, Eupolyphaga Seu Steleophaga 3-9 part, Endothelium Corneum Gigeriae Galli 10-20 part, Bombyx mori L. 4-14 part, Ramulus et folium taxi cuspidatae 7-17 part, Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Squama Manis 4-14 part, Fructus Crataegi 10-20 part, Radix Cyathulae 13-23 part, Spina Gleditsiae 19-29 part, Semen Cuscutae 13-23 part, Semen Plantaginis 13-23 part, Fructus Ligustri Lucidi 10-20 part, Radix Scrophulariae 10-20 part, Radix Rehmanniae Preparata 13-23 part, Herba Verbenae 10-20 part, Herba Leonuri 10-20 part, Herba Dianthi 13-23 part.

Wherein be preferably: Rhizoma Atractylodis 15 parts, Rhizoma Cyperi 12 parts, Cortex Moutan 15 parts, Pericarpium Citri Reticulatae 12 parts, the Rhizoma Pinelliae 9 parts, 15 parts, Poria, Herba Lycopi 12 parts, Arisaema Cum Bile 9 parts, Fructus Aurantii Immaturus 12 parts, Rhizoma Sparganii 12 parts, Rhizoma Curcumae 12 parts, Eupolyphaga Seu Steleophaga 6 parts, Endothelium Corneum Gigeriae Galli 15 parts, Bombyx mori L. 9 parts, Ramulus et folium taxi cuspidatae 12 parts, Pseudobulbus Cremastrae Seu Pleiones 15 parts, Squama Manis 9 parts, Fructus Crataegi 15 parts, Radix Cyathulae 18 parts, Spina Gleditsiae 24 parts, Semen Cuscutae 18 parts, Semen Plantaginis 18 parts, Fructus Ligustri Lucidi 15 parts, Radix Scrophulariae 15 parts, Radix Rehmanniae Preparata 18 parts, Herba Verbenae 15 parts, Herba Leonuri 15 parts, Herba Dianthi 18 parts.

Chinese medicine of the present invention can adopt the conventional method of pharmaceutical preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug grind into fine powder mix homogeneously can be made powder to take after mixing it with water; Also directly decoction can be taken if desired.

The preferred preparation method of the present invention makes granule:

Step one: by weight proportion of the present invention, first becomes medicated bag by Fructus Aurantii Immaturus, Fructus Crataegi, Semen Cuscutae, Semen Plantaginis, Fructus Ligustri Lucidi bundle, is put in water and soaks about 45 minutes, filters, for subsequent use;

Step 2: by weight proportion of the present invention, take Rhizoma Atractylodis, Rhizoma Cyperi, Cortex Moutan, Rhizoma Curcumae, Radix Cyathulae, Radix Scrophulariae is put in marmite to add in step one and remains cold water after immersion, exceed powder 4 ~ 6 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 4 cm is added in residue medicinal residues, then Pericarpium Citri Reticulatae is added, the Rhizoma Pinelliae, Poria, Herba Lycopi, Rhizoma Sparganii, Eupolyphaga Seu Steleophaga, Endothelium Corneum Gigeriae Galli, Ramulus et folium taxi cuspidatae, Pseudobulbus Cremastrae Seu Pleiones, Spina Gleditsiae, Herba Verbenae, Herba Leonuri, Herba Dianthi, and the medicated bag in step one decocts about 20 minutes with the Bombyx mori L. bound up with gauze, filter, waste, obtain filtrate, merge twice filtrate, for subsequent use,

Step 3: by weight proportion of the present invention, takes Arisaema Cum Bile, Squama Manis, Radix Rehmanniae Preparata carries out pulverizing flour milling to 120 mesh sieve, for subsequent use;

Step 4: gained fine powder in step 3 is joined in the medicine soup in step 2, and when medicine soup is concentrated into about 80 DEG C, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, under 60 DEG C of environment, the thick paste of relative density 1.13 ~ 1.20, dry, pulverize into fine powder by thick paste, add appropriate Icing Sugar as diluent, ethanol as disintegrating agent as wetting agent and microcrystalline Cellulose, adopts dry granulation, makes granule.

Medicine of the present invention has the effects such as dissolving lump and resolving mass, promoting QI circulation for relieving depression, blood circulation promoting and blood stasis dispelling, spleen invigorating mind calming, and determined curative effect, side effect is little, taking convenience, do not operate on, do not stay scar, according to clinical 100 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 85%, two the total effective rate course for the treatment of 97%.

Detailed description of the invention

Embodiment one, Rhizoma Atractylodis 10 parts, Rhizoma Cyperi 7 parts, Cortex Moutan 10 parts, Pericarpium Citri Reticulatae 7 parts, the Rhizoma Pinelliae 4 parts, 10 parts, Poria, Herba Lycopi 7 parts, Arisaema Cum Bile 4 parts, Fructus Aurantii Immaturus 7 parts, Rhizoma Sparganii 7 parts, Rhizoma Curcumae 7 parts, Eupolyphaga Seu Steleophaga 3 parts, Endothelium Corneum Gigeriae Galli 10 parts, Bombyx mori L. 4 parts, Ramulus et folium taxi cuspidatae 7 parts, Pseudobulbus Cremastrae Seu Pleiones 10 parts, Squama Manis 4 parts, Fructus Crataegi 10 parts, Radix Cyathulae 13 parts, Spina Gleditsiae 19 parts, Semen Cuscutae 13 parts, Semen Plantaginis 13 parts, Fructus Ligustri Lucidi 10 parts, Radix Scrophulariae 10 parts, Radix Rehmanniae Preparata 13 parts, Herba Verbenae 10 parts, Herba Leonuri 10 parts, Herba Dianthi 13 parts.

Embodiment two, Rhizoma Atractylodis 15 parts, Rhizoma Cyperi 12 parts, Cortex Moutan 15 parts, Pericarpium Citri Reticulatae 12 parts, the Rhizoma Pinelliae 9 parts, 15 parts, Poria, Herba Lycopi 12 parts, Arisaema Cum Bile 9 parts, Fructus Aurantii Immaturus 12 parts, Rhizoma Sparganii 12 parts, Rhizoma Curcumae 12 parts, Eupolyphaga Seu Steleophaga 6 parts, Endothelium Corneum Gigeriae Galli 15 parts, Bombyx mori L. 9 parts, Ramulus et folium taxi cuspidatae 12 parts, Pseudobulbus Cremastrae Seu Pleiones 15 parts, Squama Manis 9 parts, Fructus Crataegi 15 parts, Radix Cyathulae 18 parts, Spina Gleditsiae 24 parts, Semen Cuscutae 18 parts, Semen Plantaginis 18 parts, Fructus Ligustri Lucidi 15 parts, Radix Scrophulariae 15 parts, Radix Rehmanniae Preparata 18 parts, Herba Verbenae 15 parts, Herba Leonuri 15 parts, Herba Dianthi 18 parts.

Embodiment three, Rhizoma Atractylodis 20 parts, Rhizoma Cyperi 17 parts, Cortex Moutan 20 parts, Pericarpium Citri Reticulatae 17 parts, the Rhizoma Pinelliae 14 parts, 20 parts, Poria, Herba Lycopi 17 parts, Arisaema Cum Bile 14 parts, Fructus Aurantii Immaturus 17 parts, Rhizoma Sparganii 17 parts, Rhizoma Curcumae 17 parts, Eupolyphaga Seu Steleophaga 9 parts, Endothelium Corneum Gigeriae Galli 20 parts, Bombyx mori L. 14 parts, Ramulus et folium taxi cuspidatae 17 parts, Pseudobulbus Cremastrae Seu Pleiones 20 parts, Squama Manis 14 parts, Fructus Crataegi 20 parts, Radix Cyathulae 23 parts, Spina Gleditsiae 29 parts, Semen Cuscutae 23 parts, Semen Plantaginis 23 parts, Fructus Ligustri Lucidi 20 parts, Radix Scrophulariae 20 parts, Radix Rehmanniae Preparata 23 parts, Herba Verbenae 20 parts, Herba Leonuri 20 parts, Herba Dianthi 23 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept patient's totally 100 examples for medical treatment, the age, at 20-40 etc. 32 years old mean age, the state of an illness time was not etc.

Two, diagnostic criteria

1, clinical manifestation: patient has one or more in following symptom: 1) menoxenia: amenorrhea, infrequent menstruation before amenorrhea, very few, minority ischemia or inadequate luteal function.2) hirsutism: chaeta, pubes are dense.3) fat: moderate obesity.4) infertile: caused by anovulation.

2, sign: detect abnormal uterine, bilateral ovaries increases.

3, B is super detects: typical person can show the polycystic ovary image of multiple follicles that bilateral ovaries increases.

Three, Therapeutic Method

According to Medications Example two of the present invention, and granule prepared by preferred preparation method, one day three times, each one bag, decoction being taken warmly.It within 30th, is a course for the treatment of.

Four, efficacy assessment standard

Cure: menstrual cycle is normal, hormonal readiness measures normal, and B surpasses detection normal ovulation, and B surpasses the disappearance of ovary many cystic sign.

Take a turn for the better: menstrual cycle is normal, hormonal readiness measures LH/FSH ratio to be reduced, and T value reduces, and B surpasses detection and to have superiority ovarian follicular growth but anovulation, many cystic minimizings of B ultrasonic ovary or singly survey disappearance.

Do not heal: clinical symptoms is without improvement, and hormonal readiness measures without changing, and super detection of B grows without dominant follicle, it is unchanged that B surpasses ovary many cystic sign.

Five, therapeutic outcome statistics

Wherein: total effective rate=cure rate+improvement rate

Shown by the statistics of therapeutic outcome, Chinese medicine of the present invention has good clinical effectiveness in treatment polycystic ovarian syndrome, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.

Model case and curative effect:

Case one, Zhang, female, 29 years old, patient's bodily form is fat, lip hair, shank-feathering is longer, patient is through ultrasound diagnosis, be diagnosed as polycystic ovarian syndrome, patient does not wish to adopt the mode of Western medicine to treat, determine method fundamentally the treating from health adopting traditional Chinese medical science conditioning, adopt the preferred preparation method of the embodiment of the present invention two and institute, after taking two courses for the treatment of, symptom obviously alleviates, menstrual cycle recovers normal gradually, fat phenomenon is also controlled, body weight starts to reduce, after adhere to again taking two courses for the treatment of, hospital is gone to check, the indices such as B ultrasonic are all normal, after drug withdrawal, cycle is normal, conceived smoothly about half a year, recovery from illness.

Case two, Wu, female, 26 years old, patient's readme was miscarried once the year before, menstrual cycle is always abnormal afterwards, Hypomenorrhea, and health is unconsciously more fat many than in the past, lip hair, shank-feathering also increases, patient removes examination in hospital, last diagnostic is polycystic ovarian syndrome, patient considers to treat by the method little to later child's side effect, so adopt made granule in the invention process case two, after patient takes two courses for the treatment of, recover normal gradually through amount, somatosensory is clearly better, rear patient continues to take two courses for the treatment of, patient's readme symptom disappears substantially, hospital is gone to check, every check result is all normal, and seven month after drug withdrawal becomes pregnant successfully, recovery from illness.

Case three, Lee, female, 31 years old, patient's readme starts so far since menophania, menstruation be all two or three months just once, menstrual period, always all abnormal through amount, patient does not pay attention to this thing always, until marry 4 years, standby so far pregnant, always all could not be successful, patient removes many examination in hospital, be diagnosed as polycystic ovarian syndrome, patient upon somebody's introduction, come here to go to a doctor, patient adopts made granule in the invention process case two, after taking two courses for the treatment of, patient menstrual period, recover normal through amount, patient continues inspection and has taken three courses for the treatment of, hospital is gone to check, bilateral ovaries display normal in size, about patient's drug withdrawal later six months, become pregnant smoothly, recovery from illness.

Claims (4)

1. treat the Chinese medicine preparation of polycystic ovarian syndrome for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Rhizoma Atractylodis 10-20 part, Rhizoma Cyperi 7-17 part, Cortex Moutan 10-20 part, Pericarpium Citri Reticulatae 7-17 part, Rhizoma Pinelliae 4-14 part, Poria 10-20 part, Herba Lycopi 7-17 part, Arisaema Cum Bile 4-14 part, Fructus Aurantii Immaturus 7-17 part, Rhizoma Sparganii 7-17 part, Rhizoma Curcumae 7-17 part, Eupolyphaga Seu Steleophaga 3-9 part, Endothelium Corneum Gigeriae Galli 10-20 part, Bombyx mori L. 4-14 part, Ramulus et folium taxi cuspidatae 7-17 part, Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Squama Manis 4-14 part, Fructus Crataegi 10-20 part, Radix Cyathulae 13-23 part, Spina Gleditsiae 19-29 part, Semen Cuscutae 13-23 part, Semen Plantaginis 13-23 part, Fructus Ligustri Lucidi 10-20 part, Radix Scrophulariae 10-20 part, Radix Rehmanniae Preparata 13-23 part, Herba Verbenae 10-20 part, Herba Leonuri 10-20 part, Herba Dianthi 13-23 part.

2. the Chinese medicine preparation of the treatment polycystic ovarian syndrome according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: Rhizoma Atractylodis 15 parts, Rhizoma Cyperi 12 parts, Cortex Moutan 15 parts, Pericarpium Citri Reticulatae 12 parts, the Rhizoma Pinelliae 9 parts, 15 parts, Poria, Herba Lycopi 12 parts, Arisaema Cum Bile 9 parts, Fructus Aurantii Immaturus 12 parts, Rhizoma Sparganii 12 parts, Rhizoma Curcumae 12 parts, Eupolyphaga Seu Steleophaga 6 parts, Endothelium Corneum Gigeriae Galli 15 parts, Bombyx mori L. 9 parts, Ramulus et folium taxi cuspidatae 12 parts, Pseudobulbus Cremastrae Seu Pleiones 15 parts, Squama Manis 9 parts, Fructus Crataegi 15 parts, Radix Cyathulae 18 parts, Spina Gleditsiae 24 parts, Semen Cuscutae 18 parts, Semen Plantaginis 18 parts, Fructus Ligustri Lucidi 15 parts, Radix Scrophulariae 15 parts, Radix Rehmanniae Preparata 18 parts, Herba Verbenae 15 parts, Herba Leonuri 15 parts, Herba Dianthi 18 parts.

3. the Chinese medicine preparation for the treatment of polycystic ovarian syndrome according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is granule.

4. the preparation method for the Chinese medicine preparation of polycystic ovarian syndrome, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, first Fructus Aurantii Immaturus, Fructus Crataegi, Semen Cuscutae, Semen Plantaginis, Fructus Ligustri Lucidi bundle are become medicated bag, be put in water and soak about 45 minutes, filter, for subsequent use, step 2: by weight proportion of the present invention, take Rhizoma Atractylodis, Rhizoma Cyperi, Cortex Moutan, Rhizoma Curcumae, Radix Cyathulae, Radix Scrophulariae is put in marmite to add in step one and remains cold water after immersion, exceed powder 4 ~ 6 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 4 cm is added in residue medicinal residues, then Pericarpium Citri Reticulatae is added, the Rhizoma Pinelliae, Poria, Herba Lycopi, Rhizoma Sparganii, Eupolyphaga Seu Steleophaga, Endothelium Corneum Gigeriae Galli, Ramulus et folium taxi cuspidatae, Pseudobulbus Cremastrae Seu Pleiones, Spina Gleditsiae, Herba Verbenae, Herba Leonuri, Herba Dianthi, and the medicated bag in step one decocts about 20 minutes with the Bombyx mori L. bound up with gauze, filter, waste, obtain filtrate, merge twice filtrate, for subsequent use, step 3: by weight proportion of the present invention, takes Arisaema Cum Bile, Squama Manis, Radix Rehmanniae Preparata carries out pulverizing flour milling to 120 mesh sieve, for subsequent use, step 4: gained fine powder in step 3 is joined in the medicine soup in step 2, and when medicine soup is concentrated into about 80 DEG C, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, under 60 DEG C of environment, the thick paste of relative density 1.13 ~ 1.20, dry, pulverize into fine powder by thick paste, add appropriate Icing Sugar as diluent, ethanol as disintegrating agent as wetting agent and microcrystalline Cellulose, adopts dry granulation, makes granule.