CN105311527A - Traditional Chinese medicine preparation used for treating endometriosis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation used for treating endometriosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines and in particular relates to a traditional Chinese medicine preparation used for treating endometriosis. The traditional Chinese medicine preparation is composed of motherwort herb, white paeony root, prepared fleeceflower root, herb of aquatic malachium, clethra loosestrife herb, rhizoma corydalis, lesser galangal rhizome, herb of Yunnan begonia, suberect spatholobus stem, herb of Christina loosestrife, glabrous greenbrier rhizome, clove, humifuse euphorbia herb, peach seed, common curculigo rhizome, prepared rhizome of adhesive rehmannia, Szechuan lovage rhizome, Danshen root, szechwan chinaberry fruit, herb of large starwort, fruit of fiverleaf akebia, root of common securidaca, lychee seed, hirsute shiny bugleweed herb, Jackinthepulpit tuber, largehead atractylodes rhizome, coix seed, European verbena, radix codonopsis, and the like. Compared with the prior art, the traditional Chinese medicine preparation has the advantages of good curative effects, low cost, small limitation, no adverse reactions, and the like. The traditional Chinese medicine preparation is simple in production process and safe in medication, is stable and reliable, has good curative effects and is an effective medicine for treating endometriosis. Compared with medicines of the same kind, the medicine has the characteristics of rigorous compatibility, mild properties and obvious curative effects and is convenient to clinically popularize and apply in a large area.
Description
Technical field
The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to a kind of Chinese medicine preparation being used for the treatment of endometriosis and preparation method thereof.
Background technology
Endometriosis refers to that endo cell is planted in abnormal position and a kind of women's Common Gynecologic Diseases formed.Endo cell should grow in cavity of uterus, but is communicated with pelvic cavity by fallopian tube due to cavity of uterus, therefore makes endo cell can enter pelvic cavity ectopic growth via fallopian tube.Have multiple saying to the mechanism of this sick morbidity at present, what be wherein commonly recognized is endometrial implantation theory.In addition, the generation of endometriosis is also relevant with the immunologic function of body, inherited genetic factors, environmental factors.
The therapeutic scheme of endometriosis, because of the weight of the state of an illness, the age of patient and fertility condition and different.As the state of an illness is heavier, or show the dysmenorrhea of attaching most importance to, or pelvioscopy finds that there is the Endometriosis tuberosity of affirmative, just must take medicine or operative treatment.But in operation plan, if patient is young, do not have children, during operation, the pathological changes of Endometriosis is excised by general, and is remained in uterus and normal ovarian tissue, is called conservative operation dealing.This operation remains the probability of fertility, but recurrence chance is larger.As existing children and patient age is comparatively large, while excision endometriotic lesions, can hysterectomize, but retain normal ovary tissue.In the long term, effect is better than conservative operation dealing to this method, but definitely can not prevent recurrence.If patient is close on menopause, or endometriotic lesions is too extensive, is difficult to thorough elimination, then ovary and uterus together should be excised when performing the operation.
In drug treatment, modern study is thought, this disease is a kind of estrogen-dependent and autoimmune response disease, is endometrial gland and other positions of the health of interstitial dystopy outside cavity of uterus and basic unit with growth function.Modern clinical treatment primary disease is mainly with hormone medicine in conjunction with operative treatment, and clinical efficacy is very dissatisfied.
In recent years, Chinese medicine endometriosis shows unique superiority in clinical practice, becomes the focus of this area research at present.A large amount of clinical and experimentatioies fully confirms, the basis of traditional western medicine adds and carries out Coryza Treated by Syndrome Differentiation in raising curative effect with Chinese medicine, reduce Western medicine untoward reaction, reduce Western medicine consumption, reduce relapse rate, the aspects such as complication play a significant role.
Summary of the invention
In order to overcome deficiency of the prior art, the invention provides a kind of Chinese medicine preparation being used for the treatment of endometriosis, to acute endometriosis, there is significant curative effect.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine preparation being used for the treatment of endometriosis, is made up of each component of following parts by weight:
Herba Leonuri 1-30 part, Radix Paeoniae Alba 1-30 part, Radix Polygoni Multiflori Preparata 1-30 part, Herba malachii aquatici 1-30 part, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 1-30 part, Rhizoma Corydalis 1-30 part, Rhizoma Alpiniae Officinarum 1-30 part, Herba Begoniae Yunnanensis 1-30 part, Caulis Spatholobi 1-30 part, Herba Lysimachiae 1-30 part, Rhizoma Smilacis Glabrae 1-30 part, Flos Caryophylli 1-30 part, Herba Euphorbiae Humifusae 1-30 part, Semen Persicae 1-30 part, Rhizoma Curculiginis 1-30 part, Radix Rehmanniae Preparata 1-30 part, Rhizoma Chuanxiong 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Fructus Toosendan 1-30 part, Herba Stellariae paniculigerae 1-30 part, Fructus Akebiae 1-30 part, Radix securidacae 1-30 part, Semen Litchi 1-30 part, Herba Lycopi 1-30 part, Rhizoma Arisaematis 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Semen Coicis 1-30 part, Herba Verbenae 1-30 part, Radix Codonopsis 1-30 part, Radix Bupleuri 1-30 part, Fructus Lycii 1-30 part, Semen Cassiae 1-30 part, Radix Astragali 1-30 part, Radix Glycyrrhizae 1-30 part, Radix Notoginseng 1-30 part, Radix Angelicae Sinensis 1-30 part, Folium Artemisiae Argyi 1-30 part, Fructus Trichosanthis 1-30 part, Fructus Corni 1-30 part, Sanguis Draxonis 1-30 part, Fructus Forsythiae 1-30 part, Herba Taraxaci 1-30 part, Herba Violae 1-30 part, Radix Isatidis 1-30 part, Folium Isatidis 1-30 part, Radix Trichosanthis 1-30 part.
The Chinese medicine preparation of described treatment endometriosis, in Chinese medicine preparation described in it, the parts by weight of various crude drug can be preferably:
Herba Leonuri 10-30 part, Radix Paeoniae Alba 10-30 part, Radix Polygoni Multiflori Preparata 10-30 part, Herba malachii aquatici 10-30 part, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 10-30 part, Rhizoma Corydalis 10-30 part, Rhizoma Alpiniae Officinarum 10-30 part, Herba Begoniae Yunnanensis 10-30 part, Caulis Spatholobi 10-30 part, Herba Lysimachiae 10-30 part, Rhizoma Smilacis Glabrae 10-30 part, Flos Caryophylli 10-30 part, Herba Euphorbiae Humifusae 10-30 part, Semen Persicae 10-30 part, Rhizoma Curculiginis 10-30 part, Radix Rehmanniae Preparata 10-30 part, Rhizoma Chuanxiong 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Fructus Toosendan 1-30 part, Herba Stellariae paniculigerae 1-30 part, Fructus Akebiae 1-30 part, Radix securidacae 1-30 part, Semen Litchi 1-30 part, Herba Lycopi 1-30 part, Rhizoma Arisaematis 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Semen Coicis 1-30 part, Herba Verbenae 1-30 part, Radix Codonopsis 1-30 part, Radix Bupleuri 1-30 part, Fructus Lycii 1-30 part, Semen Cassiae 1-30 part, Radix Astragali 1-30 part, Radix Glycyrrhizae 1-30 part, Radix Notoginseng 1-30 part, Radix Angelicae Sinensis 1-30 part, Folium Artemisiae Argyi 1-30 part, Fructus Trichosanthis 1-30 part, Fructus Corni 1-30 part, Sanguis Draxonis 1-30 part, Fructus Forsythiae 1-30 part, Herba Taraxaci 1-30 part, Herba Violae 1-30 part, Radix Isatidis 1-30 part, Folium Isatidis 1-30 part, Radix Trichosanthis 1-30 part.
The Chinese medicine preparation of described treatment endometriosis, in Chinese medicine preparation described in it, the parts by weight of various crude drug can also be preferably:
Herba Leonuri 10-30 part, Radix Paeoniae Alba 10-30 part, Radix Polygoni Multiflori Preparata 10-30 part, Herba malachii aquatici 10-30 part, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 10-30 part, Rhizoma Corydalis 10-30 part, Rhizoma Alpiniae Officinarum 10-30 part, Herba Begoniae Yunnanensis 10-30 part, Caulis Spatholobi 10-30 part, Herba Lysimachiae 10-30 part, Rhizoma Smilacis Glabrae 10-30 part, Flos Caryophylli 10-30 part, Herba Euphorbiae Humifusae 10-30 part, Semen Persicae 10-30 part, Rhizoma Curculiginis 10-30 part, Radix Rehmanniae Preparata 10-30 part, Rhizoma Chuanxiong 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Fructus Toosendan 1-30 part, Herba Stellariae paniculigerae 5-30 part, Fructus Akebiae 1-30 part, Radix securidacae 1-30 part, Semen Litchi 10-30 part, Herba Lycopi 10-30 part, Rhizoma Arisaematis 10-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Semen Coicis 15-30 part, Herba Verbenae 15-30 part, Radix Codonopsis 15-30 part, Radix Bupleuri 5-30 part, Fructus Lycii 1-30 part, Semen Cassiae 15-30 part, Radix Astragali 15-30 part, Radix Glycyrrhizae 15-30 part, Radix Notoginseng 15-30 part, Radix Angelicae Sinensis 15-30 part, Folium Artemisiae Argyi 15-30 part, Fructus Trichosanthis 15-30 part, Fructus Corni 15-30 part, Sanguis Draxonis 1-30 part, Fructus Forsythiae 15-30 part, Herba Taraxaci 15-30 part, Herba Violae 15-30 part, Radix Isatidis 15-30 part, Folium Isatidis 15-30 part, Radix Trichosanthis 15-30 part.
The Chinese medicine preparation of described treatment endometriosis, the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.
For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine preparation for the treatment of endometriosis, and described preparation formulation is oral solutions, and its preparation method comprises:
A, get raw material and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;
B, medicinal residues water extraction 2 times, thickening filtration is paste, is component 2;
C, above-mentioned two kinds of pastes are condensed into pasty state, sterilizing, add dextrin, then vacuum freezing sealing.
In described step a, get raw material to add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-180 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating is concentrated into paste, stand for standby use, becomes component 1.
In described step b, 10 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating is concentrated into paste, stand for standby use, becomes component 2.
In described step c, above-mentioned two kinds of component pastes are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.
For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine preparation for the treatment of endometriosis, and described preparation formulation is capsule, and its preparation method comprises:
A. described raw material is put into pulverizer grinding and sieving;
B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;
C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 1 time;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine preparation for the treatment of endometriosis, and the dosage form of described endo-medicine is pill, and its preparation process comprises:
A. described crude drug is mixed, chopping, cross 120 mesh sieves, obtain thin medicated powder for subsequent use;
B. unsifted coarse powder is soaked in ethanol and extract 2 times;
C. the medicinal residues after above-mentioned steps extraction are got again, the heating and refluxing extraction that adds water 2 times;
D. merged by above-mentioned two kinds of extracting solution, decompression recycling ethanol becomes extractum, obtains thin medicated powder merge and add Mel and be twisted into pill with a step.
The present invention has the advantages such as good effect, cost is low, limitation is little, have no adverse reaction relative to prior art.Chinese medicine composition production technology of the present invention is simple, and drug safety is reliable and stable, good effect, is the active drug for the treatment of endometriosis.Compare with similar drugs, it is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, is convenient to large scale application clinically.
Detailed description of the invention
Endometriosis clinical manifestation is varied, and clinical symptoms is not often directly proportional to lesion degree.Its pathological change is cyclic hemorrhage and the surrounding tissue fibrosis of inner membrance, belongs to Chinese medicine " syndrome of blood stasis " category.
In the present invention: Herba Leonuri: nature and flavor: arduous, cool.1. supplement to the Herbal: " cold." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " acrid-sweet flavor, feeble QI temperature, nontoxic." 3. " detailed outline ": " micro-hardship of acrid in the mouth, nontoxic." 4. " book on Chinese herbal medicine just ": " mildly bitter flavor, micro-pungent.Be slightly cold, property is sliding." return through: enter pericardium, Liver Channel.1. " book on Chinese herbal medicine converges and says ": " hands, meridian of Foot-JUE YIN." 2. " medicineization justice ": " enters liver, spleen, envelope three warp." 3. " book on Chinese herbal medicine is new again ": " enters the heart, spleen, kidney three warp." function cures mainly: invigorate blood circulation, blood stasis dispelling, regulating menstruation, and disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.
The Radix Paeoniae Alba: nature and flavor: picric acid is cool.1. " herbal classic ": " bitter in the mouth is flat." 2. " WU Pu Bencao ": " paulownia monarch: sweet, nontoxic.Qi primary: salty.Li Shi: Slight Cold.Thunder God: acid." 3. " not Lu ": " acid, is flatly slightly cold, slightly poisonous." return through: enter liver, spleen channel.1. " product remittance essence is wanted ": " row hands is lunar, meridian of Foot-TAI YIN." 2. " Bencao Jingshu ": " lunar guiding drug of brothers, enters liver, spleen blood system." function cures mainly: nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
Radix Polygoni Multiflori Preparata: invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening, changes turbid blood fat reducing.For blood deficiency and yellow complexion, dizzy ear toot, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, hyperlipemia.Have enrich and benefit essence and blood, nourishing the liver is calmed the nerves, bone and muscle strengthening, and reinforce the kidney crow palpus, and see Light-headedness for blood deficiency, palpitation and insomnia is forgetful, sallow weak, the vertigo and tinnitus of Liver and kidney blood and essence asthenia, soreness of the waist and knees, seminal emission metrorrhagia and leukorrhagia, the diseases such as early whitening of beard and hair.
Herba malachii aquatici: nature and flavor: 1. " Yunnan Chinese herbal medicine ": " sweet light, flat." 2. " Shaanxi Chinese herbal medicine ": " sour in the mouth, property is put down." function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Control pneumonia, dysentery, hypertension, menoxenia, carbuncle hemorrhoid.1. " Yunnan Chinese herbal medicine ": " heat clearing away, relaxing muscles and tendons.Control lobar pneumonia, hypertension, menoxenia." 2. " Shaanxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.Control carbuncle, toothache, swelling and pain of hemorrhoid, dysentery."
Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis): nature and flavor: pungent puckery is flat.1. " Jiangxi medical herbs ": " property is put down, and acrid in the mouth is micro-puckery." 4. " Shaanxi Chinese herbal medicine ": " is sour and astringent, cool." function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.Control menoxenia, leucorrhea, infantile malnutrition, edema, dysentery, traumatic injury, laryngalgia, acute mastitis.1. " Zhiwu Mingshi Tukao ": " loose blood." 2. " Guizhou side's medicine among the people collection ": " diuresis.Harness the river swollen, infantile malnutrition." 3. " figure will planted by Sichuan WuLong's medicine ": " whets the appetite." 4. " Kweiyang medicinal herbs among the people ": " promoting the circulation of blood regulating menstruation, washout is subsided a swelling." 5. " Zhejiang natural resources of Chinese medicinal materials register ": " is controlled back extremity and is sprained." doctor that 6. revives " Chinese herbal medicine handbook ": " heat-clearing and toxic substances removing.Control venom, mastitis, leukorrhagia, carbuncle furuncle, epistaxis."
Rhizoma Corydalis: nature and flavor: arduous, temperature.1. " Haiyao Bencao, Oversea Materia Medica ": " bitter but sweet flavor is nontoxic." 2. " Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." return through: enter liver, stomach warp.1. Materia Medica of Decoction: " meridian of Foot-TAI YIN of starting with." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " enters lunar spleen, lung, and a cloud walks Liver Channel again." 3. " Thunder God concocts property of medicine solution ": " enters the heart, lung, spleen, stomach four warp." function cures mainly: invigorate blood circulation, and dissipating blood stasis is regulated the flow of vital energy, pain relieving.Control all pains of trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.1. Lei Gong's Treatise on Preparation and Broiling of Materia Medica: " control pained for extremely." 2. " Japan hanako materia medica ": ", except wind, controls gas, warm waist knee joint, broken disease addiction, and flutter damage blood stasis, fall tire, and sudden and violent lumbago." 3. " Kaibao Bencao ": " main removing blood stasis, puerperal all diseases, because of the blood person of doing.Married woman's menoxenia, lumps in abdomen, and metrorrhagia drenches dew, and puerperal, blood was transported, and sudden and violent blood rushes to, and because damaging hematochezia, or wine rubs and boils clothes."
Rhizoma Alpiniae Officinarum: nature and flavor: pungent, temperature.1. " not Lu ": " temperature greatly." 2. supplement to the Herbal: " acrid in the mouth, temperature." return through: enter spleen, stomach warp.1. " Thunder God concocts property of medicine solution ": " enter spleen, stomach two warp." 7. " book on Chinese herbal medicine is newly organized ": " enters the heart and Danzhong, spleen, stomach four warp." function cures mainly: stomach warming, dispels the wind, cold expelling, circulation of qi promoting, pain relieving.Control taste invasion by pathogenic cold, coldness and pain in the epigastrium, vomiting is had loose bowels, dried meat regurgitation of choking, dyspepsia, subtertian malaria, cold addiction.1. " not Lu ": " main cruelly cold, cold in the stomach is inverse, abdominal pain due to acute vomiting and diarrhea." 2. " property of medicine opinion ": " is controlled in waist cold for a long time, and gastric qi is inverse, vomiting.Control wind, dispelling the stagnated QI, abdomen cold air pain; Go air-cooled numbness weak, treat lower air cooling against the centre of punch, stomachache, vomits and diarrhoea."
Herba Begoniae Yunnanensis: nature and flavor: mildly bitter flavor; Acid; Puckery; Slightly warm in nature.Function cures mainly: grate regulating menstruation of living; Promoting the circulation of QI to relieve pain.Main menoxenia; Dysmenorrhea; Leukorrhagia; Stomachache; Children's's pestilential pathogen; Traumatic injury.
Caulis Spatholobi: nature and flavor: ' bitter sweet, temperature.1. " decoction pieces is newly joined ": " pained fragrant micro-sweet." 2. " book on Chinese herbal medicine justice ": " temperature." 3. Jiangxi " Chinese herbology ": " bitter temperature is micro-sweet." return through: " book on Chinese herbal medicine is new again ": " enters the heart, spleen two warp." function cures mainly: invigorate blood circulation, relaxing muscles and tendons.Control soreness of waist and knee joint, paralysis and numbness, menoxenia.1. " detailed outline is picked up any lost article from the road ": " invigorate blood circulation, warm waist knee joint, paralysis." 2. " book on Chinese herbal medicine is new again ": " dry stomach of invigorating middle warmer." 3. " decoction pieces is newly joined ": " blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates.Control summer filthy infection, wind arthralgia due to stagnation of blood disease.The hematonic that " 4. " modern Practical Chinese medicinal ": " is robustness, is applicable to anemicus neural paralysis disease, as limbs and soreness of waist and knee joint, apathetic etc.Again for menoxenia, menstruation apolipsis etc., have the effect of invigorating blood circulation analgesia."
Herba Lysimachiae: nature and flavor: sweet, salty, is slightly cold.Gui Jing: return liver, gallbladder, kidney, urinary bladder channel.Function cures mainly: eliminating damp-heat, treating stranguria, detumescence.For pyretic stranguria, Sha Lin, urinates and puckeryly to have a pain, jaundice dark coloured urine, carbuncle furuncle, venom; Liver and bile stone, lithangiuria.
Rhizoma Smilacis Glabrae: nature and flavor: sweet light is flat.1. " Bencao Tujing ": " sweet in the mouth, cool in nature, nontoxic." 2. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " property is put down, and bitter in the mouth is micro-puckery." 3. " detailed outline ": " is sweet light, flat, nontoxic." return through: enter liver, stomach warp.1. " detailed outline ": " be Yang Mingben medicine." 2. " explaining abstruseness of the canon of materia medica ": " enters stomach, liver two warp." 3. " book on Chinese herbal medicine is new again ": " enters liver, spleen two warp." function cures mainly: removing toxic substances, dehumidifying, sharp joint.Control syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, furuncle, carbuncle, scrofula.
Flos Caryophylli: nature and flavor: pungent, temperature.1. " Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." 2. " detailed outline ": " is pungent, heat." return through: enter stomach, spleen, kidney channel.1. Materia Medica of Decoction: " start with lunar, bright, the shaoyin channel of foot sun." 2. " Thunder God concocts property of medicine solution ": " enters lung, spleen, stomach, kidney four warp." function cures mainly: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, tinea disease.1. " property of medicine opinion ": " control cold air stomachache." 2. " Haiyao Bencao, Oversea Materia Medica ": " main air infantile malnutrition is hidden, and bone groove labor is smelly.Control gas, black moustache is sent out, parasite killing, treats five hemorrhoid, wards off evil and uncharms.Control milk headdress flower, only multicolored fulminant dysentery, healthy energy, only cardiac and abdominal pain."
Herba Euphorbiae Humifusae: nature and flavor: pungent, flat.Gui Jing: return liver, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis.For dysentery, have loose bowels, hemoptysis, hematuria, has blood in stool, metrorrhagia, furuncle carbuncle.
Semen Persicae: nature and flavor: bitter sweet is flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, nontoxic." 3. " a thousand pieces of gold dietetic therapy ": " bitter but sweet flavor is pungent, flat, nontoxic." return through: enter the heart, liver, large intestine channel.1. Materia Medica of Decoction: " start with, meridian of Foot-JUE YIN." 2. " Thunder God concocts property of medicine solution ": " enters liver, large intestine two warp." 3. " book on Chinese herbal medicine is through separating ": " enters lung meridian, heart channel of Hand-Shaoyin, spleen meridian." function cures mainly: blood stasis removing and clots absorbing, moisturizes laxation.Control amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.
Rhizoma Curculiginis: nature and flavor: pungent, temperature, poisonous.1. " Haiyao Bencao, Oversea Materia Medica ": " sweet in the mouth, micro-ly prevents, slightly poisonous." 2. " Kaibao Bencao: " acrid in the mouth, temperature, poisonous." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " is warm in nature, and acrid in the mouth is micro-salty." 4. " detailed outline): " hot in nature." return through: enter kidney, Liver Channel.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter kidney, liver two warp." 2. " book on Chinese herbal medicine is looked for the truth ": " specially enters the gate of vitality." 3. " book on Chinese herbal medicine is new again ": " enters lung, kidney two warp." function cures mainly: the kidney warming sun, strengthening bone and muscle.Control sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula, yang deficiency cold diarrhea.
Radix Rehmanniae Preparata: nature and flavor: sweet, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Rhizoma Chuanxiong: nature and flavor: pungent, temperature.1. " herbal classic ": " acrid in the mouth, temperature." 2. " WU Pu Bencao ": " Yellow Emperor, a legendary ruler, qi primary, Thunder God: pungent, nontoxic are fragrant.Bian Que: acid, nontoxic.Li Shi: raw temperature, ripe cold." 3. Tang Materia Medica: " bitter in the mouth is pungent." 4. " book on Chinese herbal medicine just ": " acrid in the mouth is micro-sweet, temperature." return through: enter liver, gallbladder meridian.1. Materia Medica of Decoction: " meridian of Foot-JUE YIN of starting with, shaoyang channel." 2. " medicineization justice ": " enters liver, spleen, three burnt three warps." function cures mainly: activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Radix Salviae Miltiorrhizae: nature and flavor: bitter, is slightly cold.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Fructus Toosendan: nature and flavor: bitter, cold; Slightly poisonous.Gui Jing: return liver, small intestinal, urinary bladder channel.Function cures mainly: soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
Herba Stellariae paniculigerae: nature and flavor: " Kweiyang medicinal herbs among the people ": " pungent, flat, nontoxic.Function cures mainly: regulate the flow of vital energy, and removing dampness is invigorated blood circulation, only ware, removing food stagnancy, removing toxic substances.Treat for stomachache, jaundice, stool hematochezia, menoxenia, children's's food stagnation, furuncle." Kweiyang medicinal herbs among the people ": " promoting the circulation of blood is regulated the flow of vital energy, removing toxic substances of stimulating the menstrual flow, and removing dampness heat is stagnant.
Fructus Akebiae: nature and flavor: hide micro-hardship, property is put down.Return liver, stomach, urinary bladder channel.Gui Jing: liver; Stomach warp.Function cures mainly: dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor.
Radix securidacae: character: root table face canescence or khaki, have strumae; Section skin zone is thick, and core is faint yellow, has numerous pore.Nature and flavor: arduous, are slightly cold.Function cures mainly: promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, clearing away heat and promoting diuresis.Control acute gastroenteritis, traumatic injury.
Semen Litchi: nature and flavor: sweet puckery, temperature.1. " detailed outline ": " sweet, temperature, puckery, nontoxic." 2. " medical center bun is wanted ": " is sweet puckery, and temperature is micro-salty." 3. " Guangxi Chinese medicinal herbal ": " sweet and slightly bitter taste is puckery, and property is put down, nontoxic." return through: enter liver, kidney channel.1. " detailed outline ": " enter to faint the moon." 2. " Bencao Jingshu ": " enters liver, kidney." 3. " book on Chinese herbal medicine brief points ": " enters lunar, the JUE YIN meridian of foot." function cures mainly: warming middle-JIAO, regulates the flow of vital energy, pain relieving.Control gastric abscess, colicky, women's pricking caused by the stagnation of QI and blood.
Herba Lycopi: nature and flavor: toil, tepor.1. " herbal classic ": " bitter in the mouth, tepor." 2. "
wU Pu Bencao": " legendary god of farming, Yellow Emperor, a legendary ruler, qi primary, paulownia monarch: acid, nontoxic.Li Shi: temperature." 3. " not Lu ": " be sweet, nontoxic." 4. " property of medicine opinion ": " bitter in the mouth is pungent." return through; Enter liver, spleen channel.1. "
the southern regions of the Yunnan Province book on Chinese herbal medicine": " row liver, spleen two warp." 2. "
thunder God concocts property of medicine solution": " enter small intestine meridian." function cures mainly: invigorate blood circulation, row water.Control amenorrhea, lump in the abdomen, the stagnant stomachache of the stasis of blood in puerperal, body and face edema, injury from falling down, incised wound, carbuncle.
Rhizoma Arisaematis: nature and flavor: bitter, pungent, temperature; Poisonous.Gui Jing: return lung, liver, spleen channel.Function cures mainly: drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.For pertinacious phlegm cough, dizziness due to wind-phlegm, middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus.Life uses external treatment carbuncle, snake bite and insect sting.
The Rhizoma Atractylodis Macrocephalae: nature and flavor: bitter, sweet, temperature.Gui Jing: return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Semen Coicis: nature and flavor: sweet, light, cool.Gui Jing: return spleen, stomach, lung meridian.Function cures mainly: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, and row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
Herba Verbenae: nature and flavor: bitter, cool. 1. " property of medicine opinion ": " bitter in the mouth, poisonous." 2. " another name for Sichuan Province book on Chinese herbal medicine ": " bitter in the mouth, is slightly cold, nontoxic." 8. " Japan hanako materia medica: " acrid in the mouth is cool, nontoxic." 4. " Bencao Tujing ": " sweet-bitter flavor, is slightly cold, slightly poisonous." return through: enter liver, spleen channel.1. " Thunder God process of preparing Chinese medicine property of medicine solution " > Thunder God concocts property of medicine solution ": " enter liver, spleen two warp." 2. " must book on Chinese herbal medicine be joined ": " start with sun bright, meridian of Foot-JUE YIN blood system." 3. " book on Chinese herbal medicine is new again ": " enters liver, kidney two warp." function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, inducing diuresis to remove edema.Control fever caused by exogenous pathogens, jaundice due to damp-heat, edema, dysentery, malaria, diphtheria, sore throat, gonorrhea, amenorrhea, lump in the abdomen, carbuncle sore tumefacting virus, ulcerative gingivitis.
Radix Codonopsis: nature and flavor: sweet is flat.Gui Jing: return spleen, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Radix Bupleuri: nature and flavor: bitter, is slightly cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Fructus Lycii: nature and flavor: sweet, flat.1. " not Lu ": " be slightly cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Treatise on Dietetic Therapy ": " trembles with fear, nontoxic." return through: enter liver, kidney channel.1. " book on Chinese herbal medicine converges and says ": " enter few cloudy, the meridian of Foot-JUE YIN of foot." 2. " book on Chinese herbal medicine is through separating ": " enters kidney meridian, heart channel of Hand-Shaoyin." 3. " key medicine divides agent ": " enters liver, stomach two warp, double enter lung meridian." function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.
Semen Cassiae: nature and flavor: sweet, bitter, salty, is slightly cold.Gui Jing: return liver, large intestine channel.Function cures mainly: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.
The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Glycyrrhizae: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Notoginseng: nature and flavor: sweet, micro-hardship, temperature.Gui Jing: return liver, stomach warp.Function cures mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.
Radix Angelicae Sinensis: sweet in the mouth is pungent, temperature, can rise and can fall, the YIN aspect of YANG, nontoxic.Though there is upper purgation to divide, enrich blood then one.Dong Yuan calls tail removing blood stasis person, by mistake.Enter the heart, spleen, liver three are dirty.But its property is very dynamic, then QI invigorating in the Qi-tonifying drug entered, then enriches blood in the hematonic entered, then carries gas in the ascending medicine entered, enter fall by medicine then by blood also.And with cold then to tremble with fear, the Re Zere of use, nothing determines merit also.
Folium Artemisiae Argyi: nature and flavor: pungent, bitter, temperature; Slightly poisonous.Gui Jing: return liver,spleen,kidney warp.Function cures mainly: dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage; External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.Hemorrhage for deficient cold type.
Fructus Trichosanthis: nature and flavor: sweet, micro-hardship, cold.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.
Fructus Corni: nature and flavor: acid, tepor.1. " herbal classic ": " sour in the mouth is flat." 2. "
wU Pu Bencao": " legendary god of farming,
yellow Emperor, a legendary ruler,
thunder God,
bian Que: acid, nontoxic.
qi primary: pungent." 3. " not Lu ": " tepor, nontoxic." 4. " property of medicine opinion ": " salty in the mouth is pungent, hot greatly." return through: enter liver, kidney channel.1. "
soup originally grass": " enter sufficient faint the moon, shaoyin channel." 2. " medicineization justice ": " enters liver, the heart, kidney three warp." 8. "
this grass is through separating": " enter lung meridian, liver channel of foot-Jueyin." function cures mainly: invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.
Sanguis Draxonis: nature and flavor: sweet, salty is flat.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: removing blood stasis and relieving pain, hemostasia and promoting granulation.Lose for falling to flutter, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury.
Fructus Forsythiae: nature and flavor: bitter, is slightly cold.Gui Jing: return lung, the heart, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
Herba Taraxaci: nature and flavor: bitter sweet, cold.1. Tang Materia Medica: " sweet in the mouth is flat, nontoxic." 2. Li Gao: " micro-hardship, cold." 3. " book on Chinese herbal medicine is stated ": " is sweet, puts down and is slightly cold." 4. Guangzhou army " conventional Chinese herbal medicine handbook ": " is bitter sweet, cold." return through: enter liver, stomach warp.1. Li Gao: " meridian of Foot-SHAO YIN." 2. " Amplification on Materia Medica addendum ": " enters bright, the Taiyin channels of sun." function cures mainly: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.
Herba Violae: nature and flavor: bitter, acrid, cold.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.For furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.
Radix Isatidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.
Folium Isatidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Join the army for pathogenic warmth, unconsciousness due to high fever, sends out speckle dermexanthesis, jaundice, hematodiarrhoea, mumps, sore throat, erysipelas, carbuncle.
Radix Trichosanthis: nature and flavor: sweet, micro-hardship, is slightly cold.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
A, get Herba Leonuri 10 parts, the Radix Paeoniae Alba 10 parts, Radix Polygoni Multiflori Preparata 10 parts, Herba malachii aquatici 10 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 10 parts, Rhizoma Corydalis 10 parts, Rhizoma Alpiniae Officinarum 10 parts, Herba Begoniae Yunnanensis 10 parts, Caulis Spatholobi 10 parts, Herba Lysimachiae 10 parts, Rhizoma Smilacis Glabrae 10 parts, Flos Caryophylli 10 parts, Herba Euphorbiae Humifusae 10 parts, 10 parts, Semen Persicae, Rhizoma Curculiginis 10 parts, Radix Rehmanniae Preparata 10 parts, Rhizoma Chuanxiong 1 part, Radix Salviae Miltiorrhizae 1 part, Fructus Toosendan 1 part, Herba Stellariae paniculigerae 5 parts, Fructus Akebiae 1 part, Radix securidacae 1 part, Semen Litchi 10 parts, Herba Lycopi 10 parts, Rhizoma Arisaematis 10 parts, the Rhizoma Atractylodis Macrocephalae 1 part, Semen Coicis 10 parts, Herba Verbenae 10 parts, Radix Codonopsis 10 parts, Radix Bupleuri 5 parts, Fructus Lycii 1 part, Semen Cassiae 10 parts, the Radix Astragali 10 parts, 10 parts, Radix Glycyrrhizae, Radix Notoginseng 10 parts, Radix Angelicae Sinensis 10 parts, Folium Artemisiae Argyi 10 parts, Fructus Trichosanthis 10 parts, Fructus Corni 10 parts, Sanguis Draxonis 10 parts, Fructus Forsythiae 10 parts, Herba Taraxaci 10 parts, Herba Violae 10 parts, Radix Isatidis 10 parts, Folium Isatidis 10 parts, Radix Trichosanthis 10 parts of raw materials add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-180 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 1,
10 times of water gagings put into by b, the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 2;
C, above-mentioned two kinds of component pastes are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.
Embodiment 2
A. described crude drug is mixed, chopping, cross 120 mesh sieves, obtain thin medicated powder for subsequent use
B, get Herba Leonuri 10 parts, the Radix Paeoniae Alba 10 parts, Radix Polygoni Multiflori Preparata 10 parts, Herba malachii aquatici 10 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 10 parts, Rhizoma Corydalis 10 parts, Rhizoma Alpiniae Officinarum 10 parts, Herba Begoniae Yunnanensis 10 parts, Caulis Spatholobi 10 parts, Herba Lysimachiae 10 parts, Rhizoma Smilacis Glabrae 10 parts, Flos Caryophylli 10 parts, Herba Euphorbiae Humifusae 10 parts, 10 parts, Semen Persicae, Rhizoma Curculiginis 10 parts, Radix Rehmanniae Preparata 10 parts, Rhizoma Chuanxiong 1 part, Radix Salviae Miltiorrhizae 1 part, Fructus Toosendan 1 part, Herba Stellariae paniculigerae 5 parts, Fructus Akebiae 1 part, Radix securidacae 1 part, Semen Litchi 10 parts, Herba Lycopi 10 parts, Rhizoma Arisaematis 10 parts, the Rhizoma Atractylodis Macrocephalae 1 part, Semen Coicis 10 parts, Herba Verbenae 10 parts, Radix Codonopsis 10 parts, Radix Bupleuri 5 parts, Fructus Lycii 1 part, Semen Cassiae 10 parts, the Radix Astragali 10 parts, 10 parts, Radix Glycyrrhizae, Radix Notoginseng 10 parts, Radix Angelicae Sinensis 10 parts, Folium Artemisiae Argyi 10 parts, Fructus Trichosanthis 10 parts, Fructus Corni 10 parts, Sanguis Draxonis 10 parts, Fructus Forsythiae 10 parts, Herba Taraxaci 10 parts, Herba Violae 10 parts, Radix Isatidis 10 parts, Folium Isatidis 10 parts, Radix Trichosanthis 10 parts of raw materials add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-180 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 1,
10 times of water gagings put into by c, the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 2;
D, above-mentioned two kinds of extracting solution to be merged, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
Embodiment 3
A. described crude drug is mixed, chopping, cross 120 mesh sieves, obtain thin medicated powder for subsequent use
B, get Herba Leonuri 10 parts, the Radix Paeoniae Alba 10 parts, Radix Polygoni Multiflori Preparata 10 parts, Herba malachii aquatici 10 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 10 parts, Rhizoma Corydalis 10 parts, Rhizoma Alpiniae Officinarum 10 parts, Herba Begoniae Yunnanensis 10 parts, Caulis Spatholobi 10 parts, Herba Lysimachiae 10 parts, Rhizoma Smilacis Glabrae 10 parts, Flos Caryophylli 10 parts, Herba Euphorbiae Humifusae 10 parts, 10 parts, Semen Persicae, Rhizoma Curculiginis 10 parts, Radix Rehmanniae Preparata 10 parts, Rhizoma Chuanxiong 1 part, Radix Salviae Miltiorrhizae 1 part, Fructus Toosendan 1 part, Herba Stellariae paniculigerae 5 parts, Fructus Akebiae 1 part, Radix securidacae 1 part, Semen Litchi 10 parts, Herba Lycopi 10 parts, Rhizoma Arisaematis 10 parts, the Rhizoma Atractylodis Macrocephalae 1 part, Semen Coicis 10 parts, Herba Verbenae 10 parts, Radix Codonopsis 10 parts, Radix Bupleuri 5 parts, Fructus Lycii 1 part, Semen Cassiae 10 parts, the Radix Astragali 10 parts, 10 parts, Radix Glycyrrhizae, Radix Notoginseng 10 parts, Radix Angelicae Sinensis 10 parts, Folium Artemisiae Argyi 10 parts, Fructus Trichosanthis 10 parts, Fructus Corni 10 parts, Sanguis Draxonis 10 parts, Fructus Forsythiae 10 parts, Herba Taraxaci 10 parts, Herba Violae 10 parts, Radix Isatidis 10 parts, Folium Isatidis 10 parts, Radix Trichosanthis 10 parts of raw materials add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-180 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 1,
10 times of water gagings put into by c, the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 2;
D. merged by above-mentioned two kinds of extracting solution, decompression recycling ethanol becomes extractum, obtains thin medicated powder merge and add Mel and be twisted into pill with a step.
The animal toxicity test of pharmaceutical composition of the present invention
1, apply mice to carry out acute toxicity testing and show: Mouse oral gavage Chinese medicine preparation oral liquid of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Chinese medicine preparation oral liquid of the present invention is 488.8g crude drug/kg/d (LD50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.
2, SD rat is selected, give the Chinese medicine preparation pill of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
3, SD rat is selected, give the Traditional Chinese medicine preparation capsule agent of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Pharmacological experiment illustrates:
Chinese medicine composition of the present invention was in 2010 to 2015 the routine patients of clinical observation endometriosis 230, and clinical report is as follows:
1, in the routine patient of physical data 230, in age 22-50 year, the course of disease is many at 2 months to 10 years, 34 years old mean age.
2, diagnostic criteria
" Chinese medical disease Standardization of diagnosis and curative effect " that diagnosis basis State Administration of Traditional Chinese Medicine issues: 1. Progressive symmetric erythrokeratodermia dysmenorrhea; 2. menstrual period lower abdominal pain, the uncomfortable and Progressive symmetric erythrokeratodermia aggravation of lumbosacral region; 3. periodicity rectal distention stimulation symptom; 4. posterior fornix jarjavay's ligaments or isthmus uteri touch painful tubercles; 5. adnexal adhesions, enclosed mass, tuberosity sense; Before and after menstruation, adnexal masses has obvious size variation.All have one of 6. one of 3. 1. 2. add and 4. 5. can be diagnosed as this disease.
3, Therapeutic Method
Matched group is with medroxyprogestetone acetate oral medication, and treatment group Chinese medicine preparation of the present invention is treated.Matched group with medroxyprogestetone acetate, every day 0.5-1.5g, (Beijing Yimin Pharmaceutical Co., Ltd.), starts to take medicine when dysmenorrhea, and pain disappears then drug withdrawal.Experimental group takes the pill medicine of the embodiment of the present invention 3, every day twice, each one, within two weeks, is a course for the treatment of.
4, therapeutic outcome:
4.1 formulate with reference to " Chinese medicine Clinical Researches of New Drugs guideline ": recovery from illness: clinical symptoms all disappears, and pelvic lump disappears, and anemia is corrected completely, and Sterility patient was become pregnant or given birth in 2 years.Effective: clinical symptoms disappears substantially, pelvic cavity bag reduces soon.Effective: partial symptoms and sign make moderate progress.Invalid: cardinal symptom and sign is unchanged or worsen, local patholoic change has and increases the weight of trend.
4.2 result
| Group | N | Cure | Effectively | Invalid | Effectively total |
| Treatment group | 130 | 80 | 46 | 4 | 96.9％ |
| Matched group | 100 | 41 | 37 | 22 | 78.0％ |
Note: compare with matched group, 1. P < 0.01 clinical data
5, model case
Hu, female, 35 years old, medical history: menophania and dysmenorrhea, increases the weight of in gradual after marriage soon, pain time with premenstrual to being very through row mid-term, dol urg is vomitted, and need take tablet for alleviating pain at every turn and be alleviated, menorrhagia, menostaxis reaches one week, and color is dim accompanies large clot, and block goes out and slightly subtracts, waist abdomen and anus pendant pain are unbearably, time have sexual anhedonia, each menstrual cycle must be lain up, and is diagnosed as endometriosis.Take medicine of the present invention, every day twice, after 1 course for the treatment of, symptom is clearly better, and conscious face has warms sense in short-term, and stomachache obviously alleviates, and vaginal hemorrhage reduces.Continue to take 2 courses for the treatment of, recovery from illness.
Bai, female, 38 years old.Medical history: abdominal pain during menstruation companion does not practise contraception unpregnancy more than 6 years.Dysmenorrhea dol urg is vomitted, and need take tablet for alleviating pain at every turn and be alleviated, menorrhagia, menostaxis reaches more than ten skies, and color is dim accompanies large clot, and block goes out and slightly subtracts, waist abdomen and anus pendant pain unbearably, time have sexual anhedonia, be diagnosed as endometriosis.Take medicine of the present invention, every day twice, after 1 course for the treatment of, symptom is clearly better, and conscious face has warms sense in short-term, and stomachache obviously alleviates, and vaginal hemorrhage reduces.Continue to take three courses for the treatment of, recovery from illness.
The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.
Claims (10)
1. be used for the treatment of a Chinese medicine preparation for endometriosis, it is characterized in that: be made up of each component of following parts by weight:
Herba Leonuri 1-30 part, Radix Paeoniae Alba 1-30 part, Radix Polygoni Multiflori Preparata 1-30 part, Herba malachii aquatici 1-30 part, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 1-30 part, Rhizoma Corydalis 1-30 part, Rhizoma Alpiniae Officinarum 1-30 part, Herba Begoniae Yunnanensis 1-30 part, Caulis Spatholobi 1-30 part, Herba Lysimachiae 1-30 part, Rhizoma Smilacis Glabrae 1-30 part, Flos Caryophylli 1-30 part, Herba Euphorbiae Humifusae 1-30 part, Semen Persicae 1-30 part, Rhizoma Curculiginis 1-30 part, Radix Rehmanniae Preparata 1-30 part, Rhizoma Chuanxiong 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Fructus Toosendan 1-30 part, Herba Stellariae paniculigerae 1-30 part, Fructus Akebiae 1-30 part, Radix securidacae 1-30 part, Semen Litchi 1-30 part, Herba Lycopi 1-30 part, Rhizoma Arisaematis 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Semen Coicis 1-30 part, Herba Verbenae 1-30 part, Radix Codonopsis 1-30 part, Radix Bupleuri 1-30 part, Fructus Lycii 1-30 part, Semen Cassiae 1-30 part, Radix Astragali 1-30 part, Radix Glycyrrhizae 1-30 part, Radix Notoginseng 1-30 part, Radix Angelicae Sinensis 1-30 part, Folium Artemisiae Argyi 1-30 part, Fructus Trichosanthis 1-30 part, Fructus Corni 1-30 part, Sanguis Draxonis 1-30 part, Fructus Forsythiae 1-30 part, Herba Taraxaci 1-30 part, Herba Violae 1-30 part, Radix Isatidis 1-30 part, Folium Isatidis 1-30 part, Radix Trichosanthis 1-30 part.
2. a kind of Chinese medicine preparation being used for the treatment of endometriosis according to claim 1, is characterized in that: be made up of each component of following parts by weight:
Herba Leonuri 10-30 part, Radix Paeoniae Alba 10-30 part, Radix Polygoni Multiflori Preparata 10-30 part, Herba malachii aquatici 10-30 part, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 10-30 part, Rhizoma Corydalis 10-30 part, Rhizoma Alpiniae Officinarum 10-30 part, Herba Begoniae Yunnanensis 10-30 part, Caulis Spatholobi 10-30 part, Herba Lysimachiae 10-30 part, Rhizoma Smilacis Glabrae 10-30 part, Flos Caryophylli 10-30 part, Herba Euphorbiae Humifusae 10-30 part, Semen Persicae 10-30 part, Rhizoma Curculiginis 10-30 part, Radix Rehmanniae Preparata 10-30 part, Rhizoma Chuanxiong 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Fructus Toosendan 1-30 part, Herba Stellariae paniculigerae 1-30 part, Fructus Akebiae 1-30 part, Radix securidacae 1-30 part, Semen Litchi 1-30 part, Herba Lycopi 1-30 part, Rhizoma Arisaematis 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Semen Coicis 1-30 part, Herba Verbenae 1-30 part, Radix Codonopsis 1-30 part, Radix Bupleuri 1-30 part, Fructus Lycii 1-30 part, Semen Cassiae 1-30 part, Radix Astragali 1-30 part, Radix Glycyrrhizae 1-30 part, Radix Notoginseng 1-30 part, Radix Angelicae Sinensis 1-30 part, Folium Artemisiae Argyi 1-30 part, Fructus Trichosanthis 1-30 part, Fructus Corni 1-30 part, Sanguis Draxonis 1-30 part, Fructus Forsythiae 1-30 part, Herba Taraxaci 1-30 part, Herba Violae 1-30 part, Radix Isatidis 1-30 part, Folium Isatidis 1-30 part, Radix Trichosanthis 1-30 part.
3. according to a kind of Chinese medicine preparation being used for the treatment of endometriosis described in claim 1 to 2, it is characterized in that: be made up of each component of following parts by weight:
Herba Leonuri 10-30 part, Radix Paeoniae Alba 10-30 part, Radix Polygoni Multiflori Preparata 10-30 part, Herba malachii aquatici 10-30 part, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 10-30 part, Rhizoma Corydalis 10-30 part, Rhizoma Alpiniae Officinarum 10-30 part, Herba Begoniae Yunnanensis 10-30 part, Caulis Spatholobi 10-30 part, Herba Lysimachiae 10-30 part, Rhizoma Smilacis Glabrae 10-30 part, Flos Caryophylli 10-30 part, Herba Euphorbiae Humifusae 10-30 part, Semen Persicae 10-30 part, Rhizoma Curculiginis 10-30 part, Radix Rehmanniae Preparata 10-30 part, Rhizoma Chuanxiong 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Fructus Toosendan 1-30 part, Herba Stellariae paniculigerae 5-30 part, Fructus Akebiae 1-30 part, Radix securidacae 1-30 part, Semen Litchi 10-30 part, Herba Lycopi 10-30 part, Rhizoma Arisaematis 10-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Semen Coicis 15-30 part, Herba Verbenae 15-30 part, Radix Codonopsis 15-30 part, Radix Bupleuri 5-30 part, Fructus Lycii 1-30 part, Semen Cassiae 15-30 part, Radix Astragali 15-30 part, Radix Glycyrrhizae 15-30 part, Radix Notoginseng 15-30 part, Radix Angelicae Sinensis 15-30 part, Folium Artemisiae Argyi 15-30 part, Fructus Trichosanthis 15-30 part, Fructus Corni 15-30 part, Sanguis Draxonis 1-30 part, Fructus Forsythiae 15-30 part, Herba Taraxaci 15-30 part, Herba Violae 15-30 part, Radix Isatidis 15-30 part, Folium Isatidis 15-30 part, Radix Trichosanthis 15-30 part.
4. a kind of Chinese medicine preparation being used for the treatment of endometriosis according to claims 1 to 3, is characterized in that: the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.
5. a kind of preparation method being used for the treatment of the Chinese medicine preparation of endometriosis according to Claims 1-4, is characterized in that: described preparation formulation is oral solutions, comprising of its preparation method:
A, get raw material and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;
B, medicinal residues water extraction 2 times, thickening filtration is paste, is component 2;
C, above-mentioned two kinds of pastes are condensed into pasty state, sterilizing, add dextrin, then vacuum freezing sealing.
6. a kind of preparation method being used for the treatment of the Chinese medicine preparation of endometriosis according to claim 5, it is characterized in that: in described step a, get raw material to add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-180 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.。
7. a kind of preparation method being used for the treatment of the Chinese medicine preparation of endometriosis according to claim 5, it is characterized in that: in described step b, 10 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, and each extraction time is 1 ~ 2 hour, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 2.
8. a kind of preparation method being used for the treatment of the Chinese medicine preparation of endometriosis according to claim 5, it is characterized in that: in described step c, above-mentioned two kinds of component pastes are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, add dextrin, then vacuum canning sealing and get final product, directly drink during use.
9. a preparation method for the Chinese medicine preparation of the treatment endometriosis as described in claim 1 to 8, is characterized in that, described preparation formulation is capsule, comprising of its preparation method:
A. described raw material is put into pulverizer grinding and sieving;
B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;
C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 1 time;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
10. a preparation method for the Chinese medicine preparation of the treatment endometriosis as described in claim 1 to 9, is characterized in that, the dosage form of described endo-medicine is pill, and its preparation process comprises:
A. described crude drug is mixed, chopping, cross 120 mesh sieves, obtain thin medicated powder for subsequent use;
B. unsifted coarse powder is soaked in ethanol and extract 2 times;
C. the medicinal residues after above-mentioned steps extraction are got again, the heating and refluxing extraction that adds water 2 times;
D. merged by above-mentioned two kinds of extracting solution, decompression recycling ethanol becomes extractum, obtains thin medicated powder merge and add Mel and be twisted into pill with a step.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106267120A (en) * | 2016-08-08 | 2017-01-04 | 青岛友诚高新技术有限公司 | A kind of Chinese medicine for treating rhinitis preparation and preparation method thereof |
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| CN103007234A (en) * | 2012-12-28 | 2013-04-03 | 青岛华仁信息技术开发有限公司 | Traditional Chinese medicine preparation for treating dysmenorrheal caused by endometriosis and preparation method of preparation |
| CN103585317A (en) * | 2013-11-06 | 2014-02-19 | 刘翠凝 | Traditional Chinese medicine preparation for treating endometriosis |
| CN103933140A (en) * | 2014-05-05 | 2014-07-23 | 蒋国霞 | Traditional Chinese medicine for treating endometriosis |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007234A (en) * | 2012-12-28 | 2013-04-03 | 青岛华仁信息技术开发有限公司 | Traditional Chinese medicine preparation for treating dysmenorrheal caused by endometriosis and preparation method of preparation |
| CN103585317A (en) * | 2013-11-06 | 2014-02-19 | 刘翠凝 | Traditional Chinese medicine preparation for treating endometriosis |
| CN103933140A (en) * | 2014-05-05 | 2014-07-23 | 蒋国霞 | Traditional Chinese medicine for treating endometriosis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106267120A (en) * | 2016-08-08 | 2017-01-04 | 青岛友诚高新技术有限公司 | A kind of Chinese medicine for treating rhinitis preparation and preparation method thereof |
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