CN106166251A - A kind of for Chinese medicine preparation treating asthma and preparation method thereof - Google Patents

A kind of for Chinese medicine preparation treating asthma and preparation method thereof Download PDF

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Publication number
CN106166251A
CN106166251A CN201610878140.8A CN201610878140A CN106166251A CN 106166251 A CN106166251 A CN 106166251A CN 201610878140 A CN201610878140 A CN 201610878140A CN 106166251 A CN106166251 A CN 106166251A
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China
Prior art keywords
parts
radix
rhizoma
preparation
chinese medicine
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CN201610878140.8A
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Chinese (zh)
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不公告发明人
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Qingdao You Cheng New And High Technology Co Ltd
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Qingdao You Cheng New And High Technology Co Ltd
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Priority to CN2016106468989 priority Critical
Priority to CN201610646898 priority
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Publication of CN106166251A publication Critical patent/CN106166251A/en
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
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    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
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    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
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    • A61K36/8965Asparagus, e.g. garden asparagus or asparagus fern
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The present invention relates to tcm field, particularly relate to a kind of Chinese medicine preparation for treating asthma.It is made up of the Radix Astragali, Semen Sesami Nigrum, Fructus Crataegi, Radix Kansui, Radix Et Rhizoma Rhei, Fructus Trichosanthis, Periostracum Cicadae, Radix Angelicae Sinensis, Caulis Sargentodoxae, Radix Dipsaci, Scorpio, the Radix Rehmanniae, Radix Notoginseng, Flos Farfarae, Herba Plantaginis, Fructus Lycii, the Radix Paeoniae Alba, Cortex Mori, Caulis Bambusae In Taenia, the Rhizoma Anemarrhenae, Radix Aconiti Lateralis Preparata, Exocarpium Citri Rubrum, Radix Asparagi etc..The present invention has the advantages such as good effect, low cost, limitation is little, have no adverse reaction relative to prior art.Chinese medicine composition production technology of the present invention is simple, and drug safety is reliable and stable, good effect, is the active drug for the treatment of asthma.Comparing with similar drugs, it is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, it is simple to large scale application clinically.

Description

A kind of for Chinese medicine preparation treating asthma and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to a kind of Chinese medicine preparation for treating asthma and preparation side thereof Method.
Background technology
Asthma has another name called bronchial asthma.Bronchial asthma is that the chronic airway participated in by various kinds of cell and cellular component is scorching Disease, this kind of inflammation, often with causing airway reactivity to increase, causes the panting of recurrent exerbation, tachypnea, uncomfortable in chest and (or) cough etc. How symptom, occur at night and (or) morning, and this type of symptom is often accompanied by extensive and changeable airflow obstruction, can voluntarily or pass through Treat and reverse.
Asthma shows as ictal cough, uncomfortable in chest and dyspnea.Some patients expectoration, expectorant when tending to alleviating more than outbreak Many, as without concurrent infection, Chang Weibai sticks expectorant, and matter is tough, sometimes in grain of rice shape or mucus column.Order of severity during outbreak is with lasting Time individual variation is very big, and the lighter only has feeling of chest tightness, last for several minutes, severe one extremely dyspnea, continued for several weeks or more For a long time.The feature of symptom is reversibility, i.e. can alleviate within a short period of time after treatment, part natural remission, certainly, and few portion Point do not alleviate and in persistent state.Outbreak often has certain risk factor, many patient episode to have obvious biological law, every day Showing effect during morning 2~6 or increase the weight of, being typically apt to occur in when spring and summer joins or winter, some women (about 20%) is the premenstrual or phase in the moon Between asthma attack or increase the weight of.It is noted that atypia asthma patient.Some patients often using ictal cough as only symptom, face On bed, the most easily mistaken diagnosis is bronchitis;Occurring uncomfortable in chest when some teenager patients are then with motion, gas is tightly only clinical manifestation.
At present, existing asthma medications has the glucocorticoid medicine of anti-inflammatory, anti-leukotriene medicine, inflammation to be situated between Matter sustained-release agent and antagonist etc.;Controlling airway constriction is that principal agent thing has β~adrenoreceptor excitomotor, purine medicaments and anti-gallbladder The bronchodilators such as alkali medicine.Chemicals occupies critical role in terms of the treatment of asthma, but it is secondary to there is significantly poison Effect.Inhaled glucocorticoid can produce locally and systemically untoward reaction bag.Wherein local untoward reaction has thrush, sound Neigh, reactive cough and bronchospasm etc..Systemic adverse reactions mainly has growth inhibited, osteoporosis, cataract etc..β Though~adrenoreceptor excitomotor has stronger bronchiectatic activity, but the phase between tachycardia, cardiopalmus, chatter and QT can be caused Extend.High dose uses can cause hypokalemia.
Summary of the invention
In order to overcome deficiency of the prior art, the present invention provides a kind of Chinese medicine preparation for treating asthma, to asthma There is significant curative effect.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is as follows: a kind of Chinese medicine for treating asthma Preparation, is made up of each component of following parts by weight:
The Radix Astragali 0.1~16 parts, Semen Sesami Nigrum 0.1~16 parts, Fructus Crataegi 0.1~16 parts, Radix Kansui 0.1~16 parts, Radix Et Rhizoma Rhei 0.1~16 Part, Fructus Trichosanthis 0.1~16 parts, Periostracum Cicadae 0.1~16 parts, Radix Angelicae Sinensis 0.1~16 parts, Caulis Sargentodoxae 0.1~16 parts, Radix Dipsaci 0.1~16 parts, Scorpio 0.1~16 part, the Radix Rehmanniae 0.1~16 parts, Radix Notoginseng 0.1~16 parts, Flos Farfarae 0.1~16 parts, Herba Plantaginis 0.1~16 parts, Fructus Lycii 0.1~16 part, the Radix Paeoniae Alba 0.1~16 parts, Cortex Mori 0.1~16 parts, Caulis Bambusae In Taenia 0.1~16 parts, the Rhizoma Anemarrhenae 0.1~16 parts, Radix Aconiti Lateralis Preparata 0.1~ 16 parts, Exocarpium Citri Rubrum 0.1~16 parts, Radix Asparagi 0.1~16 parts, Herba Asari 0.1~16 parts, Fructus Perillae 0.1~16 parts, Rhizoma Dioscoreae 0.1~16 Part, Rhizoma Alismatis 0.1~16 parts, Fructus Schisandrae Chinensis 0.1~16 parts, Herba Taraxaci 0.1~16 parts, Rhizoma Chuanxiong 0.1~16 parts, Radix Salviae Miltiorrhizae 0.1~16 parts, Rhizoma Coptidis 0.1~16 parts, Radix Scrophulariae 0.1~16 parts, Radix Bupleuri 0.1~16 parts, Ganoderma 0.1~16 parts, Poria 0.1~16 parts, the Rhizoma Pinelliae 0.1 ~16 parts, Flos Lonicerae 0.1~16 parts, Rhizoma Arisaematis 0.1~16 parts, Cortex Moutan 0.1~16 parts, Radix Asteris 0.1~16 parts, Radix Isatidis 0.1~16 part, Herba Portulacae 0.1~16 parts, Cortex Acanthopancis 0.1~16 parts.
The Chinese medicine preparation of described treatment asthma, in its described Chinese medicine preparation, the parts by weight of various crude drug can be preferred For:
The Radix Astragali 0.1~10 parts, Semen Sesami Nigrum 0.1~10 parts, Fructus Crataegi 0.1~10 parts, Radix Kansui 0.1~10 parts, Radix Et Rhizoma Rhei 0.1~10 Part, Fructus Trichosanthis 0.1~10 parts, Periostracum Cicadae 0.1~5 parts, Radix Angelicae Sinensis 0.1~10 parts, Caulis Sargentodoxae 0.1~5 parts, Radix Dipsaci 0.1~10 parts, Scorpio 0.1~5 part, the Radix Rehmanniae 0.1~10 parts, Radix Notoginseng 0.1~5 parts, Flos Farfarae 0.1~10 parts, Herba Plantaginis 0.1~10 parts, Fructus Lycii 0.1 ~10 parts, the Radix Paeoniae Alba 0.1~5 parts, Cortex Mori 0.1~10 parts, Caulis Bambusae In Taenia 0.1~10 parts, the Rhizoma Anemarrhenae 0.1~5 parts, Radix Aconiti Lateralis Preparata 0.1~10 parts, Exocarpium Citri Rubrum 0.1~10 parts, Radix Asparagi 0.1~10 parts, Herba Asari 0.1~10 parts, Fructus Perillae 0.1~10 parts, Rhizoma Dioscoreae 0.1~10 parts, pool Rush down 0.1~10 part, Fructus Schisandrae Chinensis 0.1~5 parts, Herba Taraxaci 0.1~10 parts, Rhizoma Chuanxiong 0.1~10 parts, Radix Salviae Miltiorrhizae 0.1~10 parts, Rhizoma Coptidis 0.1~10 part, Radix Scrophulariae 0.1~5 parts, Radix Bupleuri 0.1~5 parts, Ganoderma 0.1~5 parts, Poria 0.1~10 parts, the Rhizoma Pinelliae 0.1~10 parts, Flos Lonicerae 0.1~10 parts, Rhizoma Arisaematis 0.1~10 parts, Cortex Moutan 0.1~10 parts, Radix Asteris 0.1~10 parts, Radix Isatidis 0.1~10 Part, Herba Portulacae 0.1~10 parts, Cortex Acanthopancis 0.1~5 parts.
The Chinese medicine preparation of described treatment asthma, in its described Chinese medicine preparation, the parts by weight of various crude drug can also be preferably For:
The Radix Astragali 0.1~2 parts, Semen Sesami Nigrum 0.1~5 parts, Fructus Crataegi 0.1~5 parts, Radix Kansui 0.1~5 parts, Radix Et Rhizoma Rhei 0.1~2 parts, melon Beach wormwood 0.1~5 parts, Periostracum Cicadae 0.1~2 parts, Radix Angelicae Sinensis 0.1~5 parts, Caulis Sargentodoxae 0.1~2 parts, Radix Dipsaci 0.1~2 parts, Scorpio 0.1~2 parts, The Radix Rehmanniae 0.1~5 parts, Radix Notoginseng 0.1~5 parts, Flos Farfarae 0.1~5 parts, Herba Plantaginis 0.1~5 parts, Fructus Lycii 0.1~5 parts, the Radix Paeoniae Alba 0.1~5 part, Cortex Mori 0.1~5 parts, Caulis Bambusae In Taenia 0.1~5 parts, the Rhizoma Anemarrhenae 0.1~5 parts, Radix Aconiti Lateralis Preparata 0.1~5 parts, Exocarpium Citri Rubrum 0.1~5 parts, Radix Asparagi 0.1~5 parts, Herba Asari 0.1~5 parts, Fructus Perillae 0.1~2 parts, Rhizoma Dioscoreae 0.1~5 parts, Rhizoma Alismatis 0.1~5 parts, Fructus Schisandrae Chinensis 0.1~5 part, Herba Taraxaci 0.1~5 parts, Rhizoma Chuanxiong 0.1~5 parts, Radix Salviae Miltiorrhizae 0.1~2 parts, Rhizoma Coptidis 0.1~2 parts, Radix Scrophulariae 0.1~2 parts, Radix Bupleuri 0.1~5 parts, Ganoderma 0.1~2 parts, Poria 0.1~2 parts, the Rhizoma Pinelliae 0.1~5 parts, Flos Lonicerae 0.1~2 parts, Rhizoma Arisaematis 0.1 ~5 parts, Cortex Moutan 0.1~2 parts, Radix Asteris 0.1~2 parts, Radix Isatidis 0.1~5 parts, Herba Portulacae 0.1~5 parts, Cortex Acanthopancis 0.1~5 Part.
The Chinese medicine preparation of described treatment asthma, the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, Enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution Agent, injection, suppository, plaster or syrup.
For solving above-mentioned technical problem, the present invention also provides for treating the preparation method of the Chinese medicine preparation of asthma, described preparation Dosage form is oral solutions, and its preparation method includes:
A, take raw material put in ethanol soak, heat extract 2 times, become paste, for component 1;
B, medicinal residues water extraction 2 times, thickening filtration is paste, for component 2;
C, above two paste is condensed into pasty state, sterilizing, add dextrin, then vacuum freezing seals.
In described step a, take in the ethanol of raw material addition 1~5 times amount and soak 5~10 hours, heating extraction 3 times, each 3 Hour, removing supernatant, united extraction liquid, 200 mesh filter, then the ultrafiltration post ultrafiltration that molecular weight is 10000 through damming, and ultrafiltrate subtracts Pressure concentrates the extractum of 1.10 when relative density is 80 DEG C, and heating is concentrated into paste, stand for standby use, becomes component 1.
In described step b, the medicinal residues crossed by ethanol extraction are put in 5 times amount water, and heating and refluxing extraction 3 times is extracted every time Time is 5 hours, and 200 mesh filter, then the ultrafiltration post ultrafiltration that molecular weight is 10000 through damming, and ultrafiltrate concentrating under reduced pressure is the closeest The extractum of 1.10 when degree is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 2.
In described step c, above two component paste is condensed into pasty state, concentrated solution CO 60 sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product, directly drinks during use.
For solving above-mentioned technical problem, the present invention also provides for treating the preparation method of the Chinese medicine preparation of asthma, described preparation Dosage form is capsule, and its preparation method includes:
A. described raw material is put into pulverizer grinding and sieving;
B. after sieving, remaining particulate matter puts into heating and refluxing extraction 2 times in ethanol;
Take the medicinal residues after above-mentioned ethanol extraction the most again, the heating and refluxing extraction that adds water 1 time;
D. being merged by above two extracting solution, decompression recycling ethanol is also spray-dried, obtains medicated powder;Mixing sieve obtain thin Powder loads capsule and is made as capsule.
For solving above-mentioned technical problem, the present invention also provides for treating the preparation method of the Chinese medicine preparation of asthma, described for oral administration The dosage form of medicine is pill, and its preparation process includes:
A. described crude drug is mixed, chopping, cross 200 mesh sieves, obtain thin medicated powder standby;
B. unsifted coarse powder is soaked in ethanol and extract 2 times;
Take the medicinal residues after above-mentioned steps is extracted, the heating and refluxing extraction that adds water 2 times the most again;
D. being merged by above two extracting solution, decompression recycling ethanol becomes extractum, obtains thin medicated powder with a step and merges addition honeybee Honey is twisted into pill.
The present invention has the advantages such as good effect, low cost, limitation is little, have no adverse reaction relative to prior art.This Bright Chinese medicine composition production technology is simple, and drug safety is reliable and stable, good effect, is the active drug for the treatment of asthma.With similar Medicine compares, and it is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, it is simple to large area pushes away clinically Wide application.
Detailed description of the invention
Chinese medicine is thought: the assertive evidence of asthma is lung, spleen, the dirty virtual loss of kidney three.The deficiency of the lung mainly shows as seeking Wei Bugu, imperial outer nothing Power, the resistance such as susceptible exopathogen declines;The insufficiency of the spleen immune system dysfunction, low of being mainly manifested in;Suffer from a deficiency of the kidney and mainly show as down Thalamus~hypophysis~adrenal gland~endocrine dysfunction or low;The dirty all void of lung, spleen, kidney three then cause body fluid physicochemical property and Composition changes, and produces organismic internal environment unstability and adapt malfunction.Show as nature objective reality Material and stimulation produce anaphylaxis.Furthermore, easily outbreak or the aggravation time of asthma are consistent with endocrine biorhythm, also Confirm the existence of this assertive evidence of asthma.Asthma, its pathogenesis is all that the lifting cashier of mechanism of qi is not normal, makes Lung Qi obstraction, loses fall, mistake Receive caused.Therefore the treatment to asthma, it is critical only that and make mechanism of qi in order, and make the main points of mechanism of qi in order, can sum up as declaring, drop, receive three Method, because lung qi is with Xuan Weiyong, suitable to reduce to, to receive as benefit (being contained in kidney).
The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, and sore is raw Flesh.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult Bursting, burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst;Chronic nephritis proteinuria, diabetes.
Semen Sesami Nigrum: nature and flavor: sweet, flat.Gui Jing: return liver, kidney, large intestine channel.Function cures mainly: invigorating the liver and kidney, benefiting essence-blood, and intestine moistening is dry. For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.
Fructus Crataegi: nature and flavor: sour, sweet, tepor.Gui Jing: return spleen, stomach, Liver Channel.Function cures mainly: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.With In meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain;Hyperlipemia.Burnt Hawthorn digesting intestinal stasis relieving effect strengthens.For meat stagnation, dysentery is not well.
Radix Kansui: nature and flavor: bitter, cold;Poisonous.Gui Jing: return lung, kidney, large intestine channel.Function cures mainly: removing fluid-retention by purgation.Swollen for edema Expiring, chest and abdomen hydrops, phlegm retention is gathered, and QI rising in reverse order is breathed with cough, difficulty in urination and defecation.
Radix Et Rhizoma Rhei: nature and flavor: bitter, cold.Gui Jing: return spleen, stomach, large intestine, liver, pericardium channel.Function cures mainly: purging heat and dredging bowels, removing heat from blood solution Poison, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, acute appendicitis abdomen Bitterly, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire;Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs blood system heat Poison.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis Hemostasis.Stasis of blood hemorrhage is had for heat in blood.
Fructus Trichosanthis: nature and flavor: hardship sweet, micro-, cold.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, Moisturize laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.
Periostracum Cicadae: nature and flavor: sweet, cold.Gui Jing: return lung, Liver Channel.Function cures mainly: dissipate wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic. For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.
Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Function cures mainly: replenishing and activating blood, menstruction regulating and pain relieving, intestine moistening Relieving constipation.For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, fall and flutter Damage, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Caulis Sargentodoxae: bitter in the mouth, property is put down.Return large intestine, Liver Channel.Tool removing toxicity for eliminating carbuncles, promoting blood circulation and stopping pain, expelling wind and removing dampness, disinsection efficiency.Cure mainly Acute appendicitis, dysentery, mastalgia, dysmenorrhea, amenorrhea, traumatic injury, rheumatic arthralgia, abdominal pain due to worm stagnation.
Radix Dipsaci: its slightly warm in nature, bitter in the mouth, pungent;Return liver, kidney channel.There are invigorating the liver and kidney, bone and muscle strengthening, continuous injured, effect of only metrorrhagia, Can be used for treating the diseases such as deficiency of the liver and kindey, soreness of the waist and knees, rheumatic arthralgia, injury of tendon and muscle fracture, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Wherein wine Radix Dipsaci is used for rheumatic arthralgia, injury of tendon and muscle fracture, injury from falling down, and prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.
Scorpio: nature and flavor: pungent, flat;Poisonous.Gui Jing: return Liver Channel.Function cures mainly: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain. For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
The Radix Rehmanniae: bitter but sweet flavor, gas is trembled with fear, and sinks also, and the moon is also.Start with few the moon and hands lunar.The fire of cool head, the heat of lung heat clearing liver, also Monarch drug is also.Its merit is specially in cooling blood for hemostasis, and kind treatment incised wound, antiabortive gas, stimulate the menstrual flow again, and leak-stopping collapses, and all has siddhi.But cold in nature, taste are cold Person is unsuitable multiplex.Husband's Radix Rehmanniae had both been apt to removing heat from blood, the absurd row of warm blood, or spitted blood or epistaxis or hematochezia, preferably use for monarch, and add Herba Schizonepetae With Gui Qijing, add Radix Notoginseng Mo Yizhiqi road, again what heat not except and blood incessantly.But this taste can multiplex and can not frequency With, can temporary and can not be for a long time with also.Coming also when blood, its gesture is very anxious, haves no alternative but reuse the Radix Rehmanniae, stops blooding with removing heat from blood.If blood one Only, the most preferably use the agent of temperature compensation instead, improper still enter again also with the Radix Rehmanniae.Moderns do not know its event, the god of frightened Radix Rehmanniae hemostasis, are considered as miracle wonderful Medicine, everyday decoction, the most then taste are the coolest, must be to having loose bowels, and vigour is tried out, and blood heavily comes.Not realizing the Radix Rehmanniae and use many, the anti-Radix Rehmanniae of doubting is used Few, the most more enter, and have increasing its point two, the person of realizing till death and not, the saddest also husband.
Radix Notoginseng: nature and flavor: hardship sweet, micro-, temperature.Gui Jing: return liver, stomach warp.Function cures mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For coughing up Blood, spits blood, and epistaxis is had blood in stool, and metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
Flos Farfarae: nature and flavor: hardship pungent, micro-, temperature.Gui Jing: return lung meridian.Function cures mainly: nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.For newly Chronic cough is coughed, dyspnea and cough with excessive sputum, chronic cough hemoptysis.
Herba Plantaginis: nature and flavor are sweet, cold.Can clearing away heat and promoting diuresis, liver heat removing and eyesight improving, expelling phlegm for arresting cough, eliminating dampness by diuresis antidiarrheal.It is applicable to damp and hot interior strongly fragrant Edema;The frequent micturition of appearance, urgent micturition, dysurea during urinary system infection;Summer-heat is had loose bowels, bacillary dysentery;Conjunctival congestion and swelling pain caused by liver-heat, keeps in dark place Shed tears, blurring of vision.
Fructus Lycii: sweet in the mouth, property is put down.Enter liver, kidney channel.Nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, head Dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quench one's thirst, seminal emission.
The Radix Paeoniae Alba: nature and flavor: bitter, sour, is slightly cold.Gui Jing: return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, and yin fluid astringing is only Antiperspirant.For dizziness of having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Cortex Mori: nature and flavor: sweet, cold.Gui Jing: return lung meridian.Function cures mainly: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Breathe heavily for lung-heat Cough, edema distension oliguria, appearance skin edema.
Caulis Bambusae In Taenia: nature and flavor: sweet, is slightly cold.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: removing heat-phlegm, relieves restlessness and prevents vomiting.For expectorant heat Cough, gallbladder fire holds expectorant, dysphoria with smothery sensation vomiting, palpitation with fear mistake eye, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm
The Rhizoma Anemarrhenae: nature and flavor: bitter, sweet, cold.Gui Jing: return lung, stomach, kidney channel.Function cures mainly: clearing away heat-fire, promotes the production of body fluid and moisturizes.For Fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat quenches one's thirst, dryness of the intestine constipation.
Radix Aconiti Lateralis Preparata: nature and flavor: pungent, sweet is the warmmest;Poisonous.Gui Jing: GUIXIN, kidney, spleen channel.Function cures mainly: recuperating depleted YANG and rescuing the patient from collapse, mends fire and helps Sun, by wind-cold damp pathogen.Collapse for YANG-depletion, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, YIN-cold edema, yang deficiency Diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.
Exocarpium Citri Rubrum: nature and flavor: pungent, bitter, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: cold expelling, dampness, promoting the circulation of QI, expectorant.For wind Cold cough, itching of the throat abundant expectoration, food stagnation gets sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.
Radix Asparagi: nature and flavor: sweetness and bitterness, cold.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, Great Cold, nontoxic." 3. " Yunnan South book on Chinese herbal medicine ": " cold in nature, sweet and slightly bitter taste." return through: enter lung, kidney channel.1. Materia Medica of Decoction: " lunar, meridian of Foot-SHAO YIN of starting with." 2. " this Grass is through solving ": " enter lung meridian, heart channel of Hand-Shaoyin." function cures mainly: YIN nourishing, moisturizes, lung heat clearing, pathogenic fire reducing.Control fever due to yin deficiency, cough Cough haematemesis, consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quench one's thirst, constipation.
Herba Asari: nature and flavor: pungent, temperature.Gui Jing: GUIXIN, lung, kidney channel.Function cures mainly: expelling wind and cold, sensible pain relieving, warming the lung Drink.For anemofrigid cold, headache, toothache, nasal sinusitis of having a stuffy nose, rheumatic arthralgia, phlegm retention is breathed with cough.
Fructus Perillae: nature and flavor: pungent, temperature.Gui Jing: return lung meridian.Function cures mainly: sending down the abnormal ascending QI expectorant, relievings asthma, intestine moistening.Gas is stopped up for expectorant Inverse, cough and asthma, dryness of the intestine constipation
Rhizoma Dioscoreae: nature and flavor: sweet, flat.Gui Jing: return spleen, lung, kidney channel.Function cures mainly: spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, and the kidney invigorating is puckery Essence.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung breathes with cough, and emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing is good for Stomach.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Rhizoma Alismatis: nature and flavor: sweet, cold.Gui Jing: return kidney, bladder warp.Function cures mainly: diuresis, clearing away damp-heat.For dysuria, Edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria;Hyperlipidemia.
Fructus Schisandrae Chinensis: nature and flavor: sour, sweet, temperature.Gui Jing: return lung, the heart, kidney channel.Function cures mainly: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, mends Kidney mind calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart is interior Heat is quenched one's thirst, palpitation and insomnia.
Herba Taraxaci: nature and flavor: bitter, sweet, cold.Gui Jing: return liver, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, and diuresis is led to Drench.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria
Rhizoma Chuanxiong: nature and flavor: pungent, temperature.Gui Jing: return liver, gallbladder, pericardium channel.Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For the moon Through uncomfortable, amenorrhea dysmenorrhea, lump in the abdomen stomachache, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia.
Radix Salviae Miltiorrhizae: nature and flavor: bitter, is slightly cold.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness. For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia;Hepatosplenomegaly, Angina pectoris.
Rhizoma Coptidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, pathogenic fire purging solution Poison.For damp and hot feeling of fullness, vomit acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, Toothache, quenches one's thirst, carbuncle furuncle;External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Rhizoma Zingiberis Recens Rhizoma Coptidis clearing stomach stomach function regulating preventing or arresting vomiting.Tying mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For liver stomach not With, vomit acid regurgitation.
Radix Scrophulariae: nature and flavor: sweet, bitter, salty, is slightly cold.Gui Jing: return lung, stomach, kidney channel.Function cures mainly: removing heat from blood YIN nourishing, eliminating fire and detoxication. For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle skin ulcer are hindered in Tianjin Poison.
Radix Bupleuri: nature and flavor: bitter, is slightly cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For catching a cold Heating, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official prolapses, proctoptosis.
Ganoderma: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, liver, kidney channel.Function cures mainly: invigorating QI and tranquilization, relieving cough and asthma.For Dizziness sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.
Poria: nature and flavor: sweet, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.With In edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool has loose bowels, irritability, palpitation with fear insomnia.
The Rhizoma Pinelliae: nature and flavor: pungent, temperature;Poisonous.Gui Jing: return spleen, stomach, lung meridian.Function cures mainly: drying dampness to eliminate phlegm, and stopping nausea and vomiting by lowering the adverse flow of QI disappears Painful abdominal mass eliminating stagnation.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus;Raw use External treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Flos Lonicerae: nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle Swollen furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Rhizoma Arisaematis: nature and flavor: bitter, pungent, temperature;Poisonous.Gui Jing: return lung, liver, spleen channel.Function cures mainly: drying dampness to eliminate phlegm, only dispels the wind Convulsion, mass dissipating and swelling eliminating.Cough for pertinacious phlegm, dizziness due to wind-phlegm, the heap soil or fertilizer over and around the roots of middle wind-phlegm, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, broken wound Wind.External treatment carbuncle, snake bite and insect sting are used in life.
Cortex Moutan: nature and flavor: bitter, pungent, is slightly cold.Gui Jing: GUIXIN, liver, kidney channel.Function cures mainly: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling. For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, fall and flutter the pain of injury.
Radix Asteris: nature and flavor: pungent, bitter, temperature.Gui Jing: return lung meridian.Function cures mainly: nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.Breathe heavily for abundant expectoration Coughing, new chronic cough is coughed, chronic cough hemoptysis.
Radix Isatidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For temperature poison Sending out speckle, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.
Herba Portulacae: nature and flavor: acid, cold.Function cures mainly: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For bacillary dysentery, acute gastrointestinal Inflammation, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea;Furuncle swelling toxin, eczema, herpes zoster are controlled in external.
Cortex Acanthopancis: nature and flavor: hardship pungent, micro-, temperature.Gui Jing: return spleen, kidney, heart channel.Function cures mainly: replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization. For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
A, take the Radix Astragali 2 parts, Semen Sesami Nigrum 2 parts, Fructus Crataegi 2 parts, Radix Kansui 1 part, Radix Et Rhizoma Rhei 1 part, Fructus Trichosanthis 2 parts, Periostracum Cicadae 0.1 part, Radix Angelicae Sinensis 0.1 part, Caulis Sargentodoxae 0.1 part, Radix Dipsaci 0.1 part, Scorpio 0.1 part, 1 part of the Radix Rehmanniae, Radix Notoginseng 1 part, Flos Farfarae 1 part, Herba Plantaginis 1 part, Fructus Lycii Son 2 parts, the Radix Paeoniae Alba 1 part, Cortex Mori 1 part, Caulis Bambusae In Taenia 1 part, the Rhizoma Anemarrhenae 1 part, Radix Aconiti Lateralis Preparata 1 part, Exocarpium Citri Rubrum 1 part, Radix Asparagi 1 part, Herba Asari 1 part, purple Fructus Perillae 1 part, Rhizoma Dioscoreae 1 part, Rhizoma Alismatis 1 part, Fructus Schisandrae Chinensis 1 part, Herba Taraxaci 1 part, Rhizoma Chuanxiong 1 part, Radix Salviae Miltiorrhizae 1 part, Rhizoma Coptidis 1 part, Radix Scrophulariae 0.2 Part, Radix Bupleuri 0.1 part, Ganoderma 0.1 part, 0.1 part of Poria, the Rhizoma Pinelliae 0.1 part, Flos Lonicerae 2 parts, Rhizoma Arisaematis 2 parts, Cortex Moutan 1 part, Radix Asteris 1 part, Radix Isatidis 1 part, Herba Portulacae 1 part, 1 part of raw material of Cortex Acanthopancis add in the ethanol of 1~5 times amount and soak 5~10 hours, heating carries Taking 3 times, each 3 hours, remove supernatant, united extraction liquid, 200 mesh filter, then the ultrafiltration post that molecular weight is 10000 through damming surpasses Filter, the extractum of 1.10 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 1;
B, the medicinal residues crossed by ethanol extraction are put in 5 times amount water, heating and refluxing extraction 3 times, and each extraction time is 5 little Time, 200 mesh filter, then the ultrafiltration post ultrafiltration that molecular weight is 10000 through damming, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C The extractum of 1.10, heating is concentrated into paste, stand for standby use, becomes component 2;
C, above two component paste is condensed into pasty state, concentrated solution CO 60 sterilizing, irradiation dose 8k, add dextrin, Then vacuum canning sealing and get final product, directly drinks during use.
Embodiment 2
A. described crude drug is mixed, chopping, cross 200 mesh sieves, obtain thin medicated powder standby
B, take the Radix Astragali 2 parts, Semen Sesami Nigrum 2 parts, Fructus Crataegi 2 parts, Radix Kansui 1 part, Radix Et Rhizoma Rhei 1 part, Fructus Trichosanthis 2 parts, Periostracum Cicadae 0.1 part, Radix Angelicae Sinensis 0.1 part, Caulis Sargentodoxae 0.1 part, Radix Dipsaci 0.1 part, Scorpio 0.1 part, 1 part of the Radix Rehmanniae, Radix Notoginseng 1 part, Flos Farfarae 1 part, Herba Plantaginis 1 part, Fructus Lycii Son 2 parts, the Radix Paeoniae Alba 1 part, Cortex Mori 1 part, Caulis Bambusae In Taenia 1 part, the Rhizoma Anemarrhenae 1 part, Radix Aconiti Lateralis Preparata 1 part, Exocarpium Citri Rubrum 1 part, Radix Asparagi 1 part, Herba Asari 1 part, purple Fructus Perillae 1 part, Rhizoma Dioscoreae 1 part, Rhizoma Alismatis 1 part, Fructus Schisandrae Chinensis 1 part, Herba Taraxaci 1 part, Rhizoma Chuanxiong 1 part, Radix Salviae Miltiorrhizae 1 part, Rhizoma Coptidis 1 part, Radix Scrophulariae 0.2 Part, Radix Bupleuri 0.1 part, Ganoderma 0.1 part, 0.1 part of Poria, the Rhizoma Pinelliae 0.1 part, Flos Lonicerae 2 parts, Rhizoma Arisaematis 2 parts, Cortex Moutan 1 part, Radix Asteris 1 part, Radix Isatidis 1 part, Herba Portulacae 1 part, Cortex Acanthopancis 1 part add 1~5 times amount ethanol in soak 5~10 hours, heating extraction 3 Secondary, each 3 hours, remove supernatant, united extraction liquid, 200 mesh filter, then the ultrafiltration post ultrafiltration that molecular weight is 10000 through damming, The extractum of 1.10 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 1;
C, the medicinal residues crossed by ethanol extraction are put in 5 times amount water, heating and refluxing extraction 3 times, and each extraction time is 5 little Time, 200 mesh filter, then the ultrafiltration post ultrafiltration that molecular weight is 10000 through damming, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C The extractum of 1.10, heating is concentrated into paste, stand for standby use, becomes component 2;
D, by above two component merge, decompression recycling ethanol is also spray-dried, obtains medicated powder;Mix the fine powder obtained that sieves Load capsule and be made as capsule.
Embodiment 3
A. described crude drug is mixed, chopping, cross 200 mesh sieves, obtain thin medicated powder standby
B, take the Radix Astragali 2 parts, Semen Sesami Nigrum 2 parts, Fructus Crataegi 2 parts, Radix Kansui 1 part, Radix Et Rhizoma Rhei 1 part, Fructus Trichosanthis 2 parts, Periostracum Cicadae 0.1 part, Radix Angelicae Sinensis 0.1 part, Caulis Sargentodoxae 0.1 part, Radix Dipsaci 0.1 part, Scorpio 0.1 part, 1 part of the Radix Rehmanniae, Radix Notoginseng 1 part, Flos Farfarae 1 part, Herba Plantaginis 1 part, Fructus Lycii Son 2 parts, the Radix Paeoniae Alba 1 part, Cortex Mori 1 part, Caulis Bambusae In Taenia 1 part, the Rhizoma Anemarrhenae 1 part, Radix Aconiti Lateralis Preparata 1 part, Exocarpium Citri Rubrum 1 part, Radix Asparagi 1 part, Herba Asari 1 part, purple Fructus Perillae 1 part, Rhizoma Dioscoreae 1 part, Rhizoma Alismatis 1 part, Fructus Schisandrae Chinensis 1 part, Herba Taraxaci 1 part, Rhizoma Chuanxiong 1 part, Radix Salviae Miltiorrhizae 1 part, Rhizoma Coptidis 1 part, Radix Scrophulariae 0.2 Part, Radix Bupleuri 0.1 part, Ganoderma 0.1 part, 0.1 part of Poria, the Rhizoma Pinelliae 0.1 part, Flos Lonicerae 2 parts, Rhizoma Arisaematis 2 parts, Cortex Moutan 1 part, Radix Asteris 1 part, Radix Isatidis 1 part, Herba Portulacae 1 part, Cortex Acanthopancis 1 part add 1~5 times amount ethanol in soak 5~10 hours, heating extraction 3 Secondary, each 3 hours, remove supernatant, united extraction liquid, 200 mesh filter, then the ultrafiltration post ultrafiltration that molecular weight is 10000 through damming, The extractum of 1.10 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 1;
C, the medicinal residues crossed by ethanol extraction are put in 5 times amount water, heating and refluxing extraction 3 times, and each extraction time is 5 little Time, 200 mesh filter, then the ultrafiltration post ultrafiltration that molecular weight is 10000 through damming, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C The extractum of 1.10, heating is concentrated into paste, stand for standby use, becomes component 2;
D. being merged by above two extracting solution, decompression recycling ethanol becomes extractum, obtains thin medicated powder with a step and merges addition honeybee Honey is twisted into pill.
The animal toxicity test of pharmaceutical composition of the present invention
1, apply mice to carry out acute toxicity testing to show: the Chinese medicine preparation oral liquid of the Mouse oral gavage present invention, Under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, and within about 1 hour, recovers normal, sees continuously after administration Examine 7 days, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, test result indicate that: little The maximum dosage-feeding of the Chinese medicine preparation oral liquid of the Mus oral administration gavage present invention is that (LD50 > 488.8g is raw for 488.8g crude drug/kg/d Medicine/kg).The Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d;By weighing machine, mouse stomach this The dosis tolerata of bright Chinese medicine preparation is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.
2, select SD rat, give the Chinese medicine preparation ball of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg) Agent, every day gavage once, continuous 90 days, last be administered latter 24 hours respectively group live and kill 1/2 animal (male and female half and half), remaining 1/2 moves Thing is lived after continuing to observe 2 weeks and is killed.The outward appearance of animal, general behavior, food ration, body weight change is observed, after administration 90 during test It and drug withdrawal within 2 weeks, carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, the index checking such as histopathology.Examination Testing result to show: the Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, outward appearance sign, behavior are lived Dynamic, food-intake and body weight increase change the most without exception;Three dosage groups and matched group hematological examination, blood biochemical analysis, urine Biochemical analysis all between normal range, group without significant difference;Each group main organs histopathological examination shows no obvious abnormalities.On Also change is had no after stating index drug withdrawal 2 weeks.This test dosage is respectively the 180 of clinical medicine dose, 60,20 times, according to The Chinese medicine preparation of the result of the test present invention is administered at high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) for continuous 90 days Having no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, The dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher.
3, select SD rat, give the Traditional Chinese medicine preparation capsule of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg) Agent, every day gavage once, continuous 90 days, last be administered latter 24 hours respectively group live and kill 1/2 animal (male and female half and half), remaining 1/2 moves Thing is lived after continuing to observe 2 weeks and is killed.The outward appearance of animal, general behavior, food ration, body weight change is observed, after administration 90 during test It and drug withdrawal within 2 weeks, carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, the index checking such as histopathology.Examination Testing result to show: the Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, outward appearance sign, behavior are lived Dynamic, food-intake and body weight increase change the most without exception;Three dosage groups and matched group hematological examination, blood biochemical analysis, urine Biochemical analysis all between normal range, group without significant difference;Each group main organs histopathological examination shows no obvious abnormalities.On Also change is had no after stating index drug withdrawal 2 weeks.This test dosage is respectively the 180 of clinical medicine dose, 60,20 times, according to The Chinese medicine preparation of the result of the test present invention is administered at high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) for continuous 90 days Having no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, The dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher.
Pharmacological experiment illustrates:
Chinese medicine composition of the present invention was in 2010 to 2015 years clinical observation asthma 200 example patients, and clinical report is as follows:
1, in physical data 200 example patient, age 22~50 years old, the course of disease is many in 2 months to 10 years, 34 years old mean age.
2, diagnostic criteria
(1) recurrent exerbation pant, out of breath, uncomfortable in chest or cough, how with contact allergen, cold air, physics, chemical irritation And viral upper respiratory tract infection, motion etc. are relevant;
(2) at double lung audibles and be dispersed in or diffusivity, the wheezing sound based on expiratory phase during outbreak, expiratory phase prolongation;
(3) above-mentioned symptom and sign can be alleviated or spontaneous remission through treatment;
(4) except panting caused by other diseases, out of breath, uncomfortable in chest and cough;
(5) its atypical clinical manifestations person (as without substantially panting or sign), should at least possess following 1 pulmonary function test
Positive: 1. brinchial provocation test or motion activated test are positive;2. Bronchodilation Test positive FEV1 increases >=12%, and FEV1 increase absolute value >=200ml;3. (or 2 weeks) aberration rate >=20% in peak expiratory flow (PEF) day.Symbol Close (1)~(4) bar or (4), (5) bar person, asthma can be diagnosed as.
3, Therapeutic Method
Patient is randomly divided into three groups for the treatment of groups and matched group one group, and one group of 50 example, by the Chinese medicine system of the embodiment of the present invention 1 Agent, each 2g, three times a day, warm water delivery service after meal;Within 7 days, it is 1 course for the treatment of, 2 courses for the treatment of of the lighter.Two group of 50 example, real by the present invention Execute the Chinese medicine preparation of example 2, oral, each 2g, three times a day, warm water delivery service after meal;Within 7 days, it is 1 course for the treatment of, 2 courses for the treatment of of the lighter. Three group of 50 example, with the Chinese medicine preparation of the embodiment of the present invention 3, oral, each 2g, three times a day, warm water delivery service after meal;Within 7 days, it is 1 The individual course for the treatment of, 2 courses for the treatment of of the lighter.Matched group 50 example, takes aminophylline tablets, requires to take in strict accordance with description.
4, therapeutic outcome:
4.1 criterions of therapeutical effect: (1) fully recovers: disable symptomatic treatment medicine more than 1 year, without clinical symptoms and sign;(2) effective: to send out Alleviating as symptom, number of times reduces, decreased duration;(3) invalid: the state of an illness is unchanged or increases the weight of.
4.2 result
Group Cure Take a turn for the better Invalid
Matched group 28 6 16
1 group 39 10 1
2 groups 38 10 2
3 groups 32 16 2
Note: compare with matched group, 1. P < 0.01 clinical data
5, model case
Case 1: king so-and-so, man, 59 years old, suffer from chronic bronchitis, Relapse rate, protracted course of disease, the most concurrent when 40 years old Emphysema, pulmonary heart disease, bronchiectasis, a large amount of purulent sputum obstructing airways, to gasp for breath, the rhythm of the heart accelerates.Take medicine of the present invention 3 After the course for the treatment of, breathing the most smooth and easy, cough with asthma alleviates, and nasal mucus reduces.After continuing to take 1 course for the treatment of, asthma substantially alleviates stable disease, Symptom is greatly taken on a new look, then after taking 1 course for the treatment of, returns to one's perfect health, symptom completely without, pay a return visit, recovery from illness is not recurred.
Case 2: Hu, female, 35 years old, patient's asthma 3 years, at ordinary times once dynamic asthma uncomfortable in chest, heart beating was more up to 140 Beat/min, after taking 5 courses for the treatment of of medicine of the present invention, asthma is fully recovered, and follows up a case by regular visits to, does not recurs so far.
Case 3: Hu, female, 47 years old, suffering from asthma had 4 years, annual winter asthma exacerbation, it is impossible to flat sleeping, it is impossible to fall asleep, Uncomfortable in chest, cough up phlegm, the dilutest, once took aminophylline, after use bricasol instead, but still breathe heavily after drug withdrawal.Take medicine of the present invention 2 treatment Cheng Hou, feels good, then takes 2 courses for the treatment of, breathes heavily disease recovery from illness and follows up a case by regular visits to, does not recurs so far.
The above, be only highly preferred embodiment of the present invention, and the present invention not makees any pro forma restriction, appoints What those of ordinary skill in the art, without departing under technical solution of the present invention ambit, in utilizing the method for the disclosure above Hold and technical solution of the present invention is made many possible variations and modification, belong to the scope of claims protection.

Claims (10)

1. the Chinese medicine preparation being used for treating asthma, it is characterised in that: it is made up of each component of following parts by weight:
The Radix Astragali 0.1~16 parts, Semen Sesami Nigrum 0.1~16 parts, Fructus Crataegi 0.1~16 parts, Radix Kansui 0.1~16 parts, Radix Et Rhizoma Rhei 0.1~16 parts, Fructus Trichosanthis 0.1~16 parts, Periostracum Cicadae 0.1~16 parts, Radix Angelicae Sinensis 0.1~16 parts, Caulis Sargentodoxae 0.1~16 parts, Radix Dipsaci 0.1~16 parts, Scorpio 0.1 ~16 parts, the Radix Rehmanniae 0.1~16 parts, Radix Notoginseng 0.1~16 parts, Flos Farfarae 0.1~16 parts, Herba Plantaginis 0.1~16 parts, Fructus Lycii 0.1 ~16 parts, the Radix Paeoniae Alba 0.1~16 parts, Cortex Mori 0.1~16 parts, Caulis Bambusae In Taenia 0.1~16 parts, the Rhizoma Anemarrhenae 0.1~16 parts, Radix Aconiti Lateralis Preparata 0.1~16 Part, Exocarpium Citri Rubrum 0.1~16 parts, Radix Asparagi 0.1~16 parts, Herba Asari 0.1~16 parts, Fructus Perillae 0.1~16 parts, Rhizoma Dioscoreae 0.1~16 parts, Rhizoma Alismatis 0.1~16 parts, Fructus Schisandrae Chinensis 0.1~16 parts, Herba Taraxaci 0.1~16 parts, Rhizoma Chuanxiong 0.1~16 parts, Radix Salviae Miltiorrhizae 0.1~16 parts, Huang Even 0.1~16 part, Radix Scrophulariae 0.1~16 parts, Radix Bupleuri 0.1~16 parts, Ganoderma 0.1~16 parts, Poria 0.1~16 parts, the Rhizoma Pinelliae 0.1~ 16 parts, Flos Lonicerae 0.1~16 parts, Rhizoma Arisaematis 0.1~16 parts, Cortex Moutan 0.1~16 parts, Radix Asteris 0.1~16 parts, Radix Isatidis 0.1 ~16 parts, Herba Portulacae 0.1~16 parts, Cortex Acanthopancis 0.1~16 parts.
A kind of Chinese medicine preparation for treating asthma the most according to claim 1, it is characterised in that: by following parts by weight Each component composition:
The Radix Astragali 0.1~10 parts, Semen Sesami Nigrum 0.1~10 parts, Fructus Crataegi 0.1~10 parts, Radix Kansui 0.1~10 parts, Radix Et Rhizoma Rhei 0.1~10 parts, Fructus Trichosanthis 0.1~10 parts, Periostracum Cicadae 0.1~5 parts, Radix Angelicae Sinensis 0.1~10 parts, Caulis Sargentodoxae 0.1~5 parts, Radix Dipsaci 0.1~10 parts, Scorpio 0.1~ 5 parts, the Radix Rehmanniae 0.1~10 parts, Radix Notoginseng 0.1~5 parts, Flos Farfarae 0.1~10 parts, Herba Plantaginis 0.1~10 parts, Fructus Lycii 0.1~10 Part, the Radix Paeoniae Alba 0.1~5 parts, Cortex Mori 0.1~10 parts, Caulis Bambusae In Taenia 0.1~10 parts, the Rhizoma Anemarrhenae 0.1~5 parts, Radix Aconiti Lateralis Preparata 0.1~10 parts, Exocarpium Citri Rubrum 0.1~10 part, Radix Asparagi 0.1~10 parts, Herba Asari 0.1~10 parts, Fructus Perillae 0.1~10 parts, Rhizoma Dioscoreae 0.1~10 parts, Rhizoma Alismatis 0.1 ~10 parts, Fructus Schisandrae Chinensis 0.1~5 parts, Herba Taraxaci 0.1~10 parts, Rhizoma Chuanxiong 0.1~10 parts, Radix Salviae Miltiorrhizae 0.1~10 parts, Rhizoma Coptidis 0.1~10 Part, Radix Scrophulariae 0.1~5 parts, Radix Bupleuri 0.1~5 parts, Ganoderma 0.1~5 parts, Poria 0.1~10 parts, the Rhizoma Pinelliae 0.1~10 parts, Flos Lonicerae 0.1~10 part, Rhizoma Arisaematis 0.1~10 parts, Cortex Moutan 0.1~10 parts, Radix Asteris 0.1~10 parts, Radix Isatidis 0.1~10 parts, Dens Equi Herba Amaranthi tricoloris 0.1~10 parts, Cortex Acanthopancis 0.1~5 parts.
3. according to a kind of Chinese medicine preparation for treating asthma described in claim 1 to 2, it is characterised in that: by following weight Each component composition of number:
The Radix Astragali 0.1~2 parts, Semen Sesami Nigrum 0.1~5 parts, Fructus Crataegi 0.1~5 parts, Radix Kansui 0.1~5 parts, Radix Et Rhizoma Rhei 0.1~2 parts, Fructus Trichosanthis 0.1~5 part, Periostracum Cicadae 0.1~2 parts, Radix Angelicae Sinensis 0.1~5 parts, Caulis Sargentodoxae 0.1~2 parts, Radix Dipsaci 0.1~2 parts, Scorpio 0.1~2 parts, life 0.1~5 part of ground, Radix Notoginseng 0.1~5 parts, Flos Farfarae 0.1~5 parts, Herba Plantaginis 0.1~5 parts, Fructus Lycii 0.1~5 parts, the Radix Paeoniae Alba 0.1 ~5 parts, Cortex Mori 0.1~5 parts, Caulis Bambusae In Taenia 0.1~5 parts, the Rhizoma Anemarrhenae 0.1~5 parts, Radix Aconiti Lateralis Preparata 0.1~5 parts, Exocarpium Citri Rubrum 0.1~5 parts, Tianmen Winter 0.1~5 parts, Herba Asari 0.1~5 parts, Fructus Perillae 0.1~2 parts, Rhizoma Dioscoreae 0.1~5 parts, Rhizoma Alismatis 0.1~5 parts, Fructus Schisandrae Chinensis 0.1~5 Part, Herba Taraxaci 0.1~5 parts, Rhizoma Chuanxiong 0.1~5 parts, Radix Salviae Miltiorrhizae 0.1~2 parts, Rhizoma Coptidis 0.1~2 parts, Radix Scrophulariae 0.1~2 parts, Radix Bupleuri 0.1 ~it is 5 parts, Ganoderma 0.1~2 parts, Poria 0.1~2 parts, the Rhizoma Pinelliae 0.1~5 parts, Flos Lonicerae 0.1~2 parts, Rhizoma Arisaematis 0.1~5 parts, male Cortex Moutan 0.1~2 parts, Radix Asteris 0.1~2 parts, Radix Isatidis 0.1~5 parts, Herba Portulacae 0.1~5 parts, Cortex Acanthopancis 0.1~5 parts.
4. according to a kind of Chinese medicine preparation for treating asthma described in claims 1 to 3, it is characterised in that: described Chinese medicine system The dosage form of agent is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck Agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.
5. according to the preparation method of a kind of Chinese medicine preparation for treating asthma described in Claims 1-4, it is characterised in that: Described preparation formulation is oral solutions, including of its preparation method:
A, take raw material put in ethanol soak, heat extract 2 times, become paste, for component 1;
B, medicinal residues water extraction 2 times, thickening filtration is paste, for component 2;
C, above two paste is condensed into pasty state, sterilizing, add dextrin, then vacuum freezing seals.
The preparation method of a kind of Chinese medicine preparation for treating asthma the most according to claim 5, it is characterised in that: described In step a, take in the ethanol of raw material addition 1~5 times amount and soak 5~10 hours, heating extraction 3 times, each 3 hours, remove supernatant Liquid, united extraction liquid, 200 mesh filter, then the ultrafiltration post ultrafiltration that molecular weight is 10000 through damming, and ultrafiltrate concentrating under reduced pressure is relative The extractum of 1.10 when density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 1..
The preparation method of a kind of Chinese medicine preparation for treating asthma the most according to claim 5, it is characterised in that: described In step b, the medicinal residues crossed by ethanol extraction are put in 5 times amount water, heating and refluxing extraction 3 times, and each extraction time is 5 hours, 200 mesh filter, then the ultrafiltration post ultrafiltration that molecular weight is 10000 through damming, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C The extractum of 1.10, heating is concentrated into paste, stand for standby use, becomes component 2.
The preparation method of a kind of Chinese medicine preparation for treating asthma the most according to claim 5, it is characterised in that: described In step c, above two component paste is condensed into pasty state, concentrated solution CO 60 sterilizing, irradiation dose 8k, add dextrin, so Final vacuum canning sealing and get final product, directly drinks during use.
9. the preparation method of the Chinese medicine preparation of the treatment asthma as described in claim 1 to 8, it is characterised in that described system Agent dosage form is capsule, including of its preparation method:
A. described raw material is put into pulverizer grinding and sieving;
B. after sieving, remaining particulate matter puts into heating and refluxing extraction 2 times in ethanol;
Take the medicinal residues after above-mentioned ethanol extraction the most again, the heating and refluxing extraction that adds water 1 time;
D. being merged by above two extracting solution, decompression recycling ethanol is also spray-dried, obtains medicated powder;The fine powder dress that mixing sieves obtains Enter capsule and be made as capsule.
10. the preparation method of the Chinese medicine preparation of the treatment asthma as described in claim 1 to 9, it is characterised in that in described The dosage form of thing of taking medicine is pill, and its preparation process includes:
A. described crude drug is mixed, chopping, cross 200 mesh sieves, obtain thin medicated powder standby;
B. unsifted coarse powder is soaked in ethanol and extract 2 times;
Take the medicinal residues after above-mentioned steps is extracted, the heating and refluxing extraction that adds water 2 times the most again;
D. being merged by above two extracting solution, decompression recycling ethanol becomes extractum, obtains thin medicated powder with a step and merges addition Mel stranding Become pill.
CN201610878140.8A 2016-08-08 2016-10-09 A kind of for Chinese medicine preparation treating asthma and preparation method thereof Withdrawn CN106166251A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112220846A (en) * 2020-11-24 2021-01-15 上海市青浦区中医医院 Traditional Chinese medicine composition for treating children's chronic cough and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104225200A (en) * 2014-09-30 2014-12-24 王林 Traditional Chinese medicine for treating fluid retention invading heart-lung type cardiac asthma and preparation method thereof
CN105497816A (en) * 2016-01-20 2016-04-20 姜少燕 Traditional Chinese medicine preparation for treating atherosclerosis and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104225200A (en) * 2014-09-30 2014-12-24 王林 Traditional Chinese medicine for treating fluid retention invading heart-lung type cardiac asthma and preparation method thereof
CN105497816A (en) * 2016-01-20 2016-04-20 姜少燕 Traditional Chinese medicine preparation for treating atherosclerosis and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112220846A (en) * 2020-11-24 2021-01-15 上海市青浦区中医医院 Traditional Chinese medicine composition for treating children's chronic cough and application thereof

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Application publication date: 20161130