CN104225200A

CN104225200A - Traditional Chinese medicine for treating fluid retention invading heart-lung type cardiac asthma and preparation method thereof

Info

Publication number: CN104225200A
Application number: CN201410514637.2A
Authority: CN
Inventors: 王林
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-09-30
Filing date: 2014-09-30
Publication date: 2014-12-24

Abstract

The invention discloses a traditional Chinese medicine for treating fluid retention invading heart-lung type cardiac asthma and a preparation method thereof. The traditional Chinese medicine comprises the following raw herbal materials: rhizoma arisaematis, semen brassicae, euphorbia kansui, inula flower, bryozoatum, fructus perillae, cynanchum glaucescens, aster, euphorbia pekinensis, bulbus fritillariae cirrhosae, tussilago farfara, lily, astragalus membranaceus, root bark of white mulberry, pericarpium arecae, poria cocos, semen lepidii, ginkgo nuts, schisandra chinensis, wartwort, spina date seed, polygala root, pittosporum root, lythrum salicaria, persicaria perfoliata and affine cudweed. The traditional Chinese medicine has the beneficial effects that the traditional Chinese medicine has main effects of warming yang to promote diuresis and purging the lung of pathogenic fire to relieve asthma and has a significant curative effect. Moreover, the raw herbal materials are purely natural, so the traditional Chinese medicine is smaller in toxic and side effects, can improve body immunity, and is not liable to generate drug resistance. The preparation process is simple and convenient, and the cost of raw herbal materials is low. By scientific compatibility and selection of raw herbal materials, the traditional Chinese medicine is appropriate in taste and is easily accepted by patients.

Description

A kind of Chinese medicine and preparation method for the treatment of drink icepro heart pulmonary type cardiac asthma

Technical field

The present invention relates to pharmaceutical technology, particularly a kind of Chinese medicine and preparation method for the treatment of drink icepro heart pulmonary type cardiac asthma.

Background technology

Cardiac asthma is the ictal asthma because left heart failure and acute lung edema etc. cause, and clinical manifestation during its outbreak can be similar to bronchial asthma.Cardiac asthma previously has hypertension or heart disease history, during asthma, with frequently coughing, coughing foam sample particularly blood foam sample expectorant, cardiac dilatation, and arrhythmia and hear sounds exception etc.Ridley syndrome (cardiac asthma syndrome): intrinsic mean the left heart failure caused due to a variety of causes clinical take paroxysmal nocturnal dyspnea as one group of syndrome of outstanding behaviours.

The most outstanding clinical manifestation is paroxysmal nocturnal dyspnea, cardiac asthma.Typical onset mostly occurs at nighttime sleep after 1 ~ 2 hour, and patient wakes up with a start suddenly because of unhappy, out of breath, is forced to sit up immediately and open the window, is intended to alleviate sensation of asphyxia, accompany by apasm of coughing, asthmatic breath sounds or cough frothy sputum.The lighter gets seat more than ten minutes to about 1h, and dyspnea can disappear automatically, and patient can fall asleep again.The sustainable outbreak of severe patient, again and again cough, tachypnea increases the weight of, cyanosis, dripping sweat, deadly cold hand and foot, expectoration pink foam expectorant, and can develop into acute lung edema.For one of the characteristic symptom of acute left heart failure.Main manifestations is that burst is panted, and accompanies two extensive wheezing sound of lung and coughs up pink foam sample expectorant; Most patients has heart underlying diseases; Auxiliary examination can find the evidence of the heart failure such as pulmonary venous pleonaemia, left ventricle dilation.

But western modern medicine treatment cardiac asthma is longer for the sick course for the treatment of, and curative effect is not satisfactory, easily produces drug resistance, even delay treatment, produces deformity.

Chinese medicine thinks that cardiac asthma belongs to " the syndrome of dyspnea " category.Breathe heavily disease to refer to due to diseases caused by exogenous pathogenic factor or internal injury, cause impairment of dispersing and descending function of the lung, abnormal rising of lung-QI or gas without lead, kidney loses to take the photograph and receives, so that dyspnea, very then opening mouth and lifting shoulder due to dyspnea, flaring of nares, can not equal the sleeping a kind of disease waited as main clinical characteristics.Severe patient can by breathing heavily the critical syndrome causing existing collapse syndrome caused by dyspnea.Breathe heavily disease ancient literature and also claim " breath ", " dyspnea with elevated shoulders ", " upper gas ", " inverse gas ", " dyspnea with rapid and short breath " etc.Breathing heavily disease is with the disease of symptom name, it is independence disease, also be the symptom in multiple acute and chronic lysis, therefore distinguish that its clinical syndrome is divided into the type such as insufficiency of lung-QI, deficiency of kidney-QI, collapse syndrome caused by dyspnea that cardiopulmonary insulted by the cold closed lung of excess-dyspnea, expectorant blocked heat lung, turbid phlegm obstructing in the lung, drink, irritability takes advantage of the types such as lung and dyspnea due to deficiency.Heart pulmonary type insulted by drink wherein: QI rising in reverse order of breathing with cough, and resting on the bedstead to sleep is difficult to flat sleeping, coughs up thin and whitish sputum, cardiopalmus, appearance limbs edema, and urine amount is few, and timid cold cold extremities, cyanosis on the face and lips, enlarged tongue is dim, white, slippery and moist fur, deep-thready pulse.

Chinese medicine treatment cardiac asthma, systematic theory, have accumulated abundant Couple herbs, under the prerequisite of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, has significant therapeutic effect.Further, Chinese herbal medicine is pure natural property, and toxic and side effects is less, can improve immunity of organisms, is not to produce drug resistance.Processing technology of the present invention is easy, and medical material cost price is cheap, and through scientific compatibility, selected medical material, mouthfeel is suitable for, and patient is easy to accept.

Summary of the invention

Technical problem to be solved by this invention is, provides one and has warming YANG to promote diuresis, effect of eliminating pathogen from the lung for relieving asthma, cures mainly the Chinese medicine that heart pulmonary type cardiac asthma insulted by drink.The present invention has and adopts Chinese crude drug of different nature, compatibility rigorous, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs drug effect can be gone directly focus, and healing time is short, not easily recurs more; Toxic and side effects is little, convenient drug administration, and mouthfeel is suitable for patient and is easy to accept.Further, processing technology is easy, and medicament is easy to manufacture, advantage with low cost.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of drink icepro heart pulmonary type cardiac asthma, comprise following raw medicinal material: Rhizoma Arisaematis, Semen Sinapis Albae, Radix Kansui, Flos Inulae, Pumex, Fructus Perillae, Rhizoma Cynanchi Stauntonii, Radix Asteris, the Radix Euphorbiae Pekinensis, Bulbus Fritillariae Cirrhosae, Flos Farfarae, Bulbus Lilii, the Radix Astragali, Cortex Mori, Pericarpium Arecae, Poria, Semen Lepidii (Semen Descurainiae), Semen Ginkgo, Fructus Schisandrae Chinensis, Herba Euphorbiae Helioscopiae, Semen Ziziphi Spinosae, Radix Polygalae, Radix Pittospori Glabrati, Herba Lythri Salicariae, Herba Polygoni Perfoliati and Herba Gnaphalii Affinis.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Rhizoma Arisaematis 4-9 weight portion, Semen Sinapis Albae 10-28 weight portion, Radix Kansui 5-12 weight portion, Flos Inulae 6-13 weight portion, Pumex 17-34 weight portion, Fructus Perillae 21-38 weight portion, Rhizoma Cynanchi Stauntonii 6-18 weight portion, Radix Asteris 13-26 weight portion, Radix Euphorbiae Pekinensis 3-10 weight portion, Bulbus Fritillariae Cirrhosae 25-43 weight portion, Flos Farfarae 11-29 weight portion, Bulbus Lilii 18-34 weight portion, Radix Astragali 23-37 weight portion, Cortex Mori 14-29 weight portion, Pericarpium Arecae 10-30 weight portion, Poria 23-37 weight portion, Semen Lepidii (Semen Descurainiae) 16-31 weight portion, Semen Ginkgo 26-42 weight portion, Fructus Schisandrae Chinensis 17-34 weight portion, Herba Euphorbiae Helioscopiae 3-13 weight portion, Semen Ziziphi Spinosae 20-35 weight portion, Radix Polygalae 13-29 weight portion, Radix Pittospori Glabrati 20-36 weight portion, Herba Lythri Salicariae 14-31 weight portion, Herba Polygoni Perfoliati 9-23 weight portion and Herba Gnaphalii Affinis 19-36 weight portion.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Rhizoma Arisaematis 4-7 weight portion, Semen Sinapis Albae 10-23 weight portion, Radix Kansui 5-10 weight portion, Flos Inulae 6-11 weight portion, Pumex 19-30 weight portion, Fructus Perillae 21-31 weight portion, Rhizoma Cynanchi Stauntonii 6-13 weight portion, Radix Asteris 13-21 weight portion, Radix Euphorbiae Pekinensis 3-8 weight portion, Bulbus Fritillariae Cirrhosae 27-39 weight portion, Flos Farfarae 13-25 weight portion, Bulbus Lilii 20-30 weight portion, Radix Astragali 25-34 weight portion, Cortex Mori 17-27 weight portion, Pericarpium Arecae 13-28 weight portion, Poria 27-35 weight portion, Semen Lepidii (Semen Descurainiae) 16-27 weight portion, Semen Ginkgo 29-39 weight portion, Fructus Schisandrae Chinensis 20-30 weight portion, Herba Euphorbiae Helioscopiae 4-11 weight portion, Semen Ziziphi Spinosae 23-32 weight portion, Radix Polygalae 13-21 weight portion, Radix Pittospori Glabrati 23-33 weight portion, Herba Lythri Salicariae 16-29 weight portion, Herba Polygoni Perfoliati 9-20 weight portion and Herba Gnaphalii Affinis 21-33 weight portion.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Rhizoma Arisaematis 4 weight portion, Semen Sinapis Albae 10 weight portion, Radix Kansui 5 weight portion, Flos Inulae 6 weight portion, Pumex 19 weight portion, Fructus Perillae 31 weight portion, Rhizoma Cynanchi Stauntonii 7 weight portion, Radix Asteris 13 weight portion, the Radix Euphorbiae Pekinensis 3 weight portion, Bulbus Fritillariae Cirrhosae 39 weight portion, Flos Farfarae 16 weight portion, Bulbus Lilii 22 weight portion, the Radix Astragali 27 weight portion, Cortex Mori 17 weight portion, Pericarpium Arecae 18 weight portion, Poria 35 weight portion, Semen Lepidii (Semen Descurainiae) 27 weight portion, Semen Ginkgo 39 weight portion, Fructus Schisandrae Chinensis 26 weight portion, Herba Euphorbiae Helioscopiae 4 weight portion, Semen Ziziphi Spinosae 32 weight portion, Radix Polygalae 13 weight portion, Radix Pittospori Glabrati 27 weight portion, Herba Lythri Salicariae 29 weight portion, Herba Polygoni Perfoliati 20 weight portion and Herba Gnaphalii Affinis 33 weight portion.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Rhizoma Arisaematis 6 weight portion, Semen Sinapis Albae 23 weight portion, Radix Kansui 10 weight portion, Flos Inulae 11 weight portion, Pumex 30 weight portion, Fructus Perillae 29 weight portion, Rhizoma Cynanchi Stauntonii 6 weight portion, Radix Asteris 21 weight portion, the Radix Euphorbiae Pekinensis 8 weight portion, Bulbus Fritillariae Cirrhosae 27 weight portion, Flos Farfarae 25 weight portion, Bulbus Lilii 20 weight portion, the Radix Astragali 25 weight portion, Cortex Mori 27 weight portion, Pericarpium Arecae 13 weight portion, Poria 27 weight portion, Semen Lepidii (Semen Descurainiae) 19 weight portion, Semen Ginkgo 29 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Herba Euphorbiae Helioscopiae 11 weight portion, Semen Ziziphi Spinosae 24 weight portion, Radix Polygalae 21 weight portion, Radix Pittospori Glabrati 23 weight portion, Herba Lythri Salicariae 16 weight portion, Herba Polygoni Perfoliati 10 weight portion and Herba Gnaphalii Affinis 21 weight portion.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Rhizoma Arisaematis 5 weight portion, Semen Sinapis Albae 13 weight portion, Radix Kansui 8 weight portion, Flos Inulae 7 weight portion, Pumex 22 weight portion, Fructus Perillae 21 weight portion, Rhizoma Cynanchi Stauntonii 13 weight portion, Radix Asteris 17 weight portion, the Radix Euphorbiae Pekinensis 6 weight portion, Bulbus Fritillariae Cirrhosae 35 weight portion, Flos Farfarae 13 weight portion, Bulbus Lilii 30 weight portion, the Radix Astragali 34 weight portion, Cortex Mori 19 weight portion, Pericarpium Arecae 28 weight portion, Poria 31 weight portion, Semen Lepidii (Semen Descurainiae) 16 weight portion, Semen Ginkgo 38 weight portion, Fructus Schisandrae Chinensis 20 weight portion, Herba Euphorbiae Helioscopiae 9 weight portion, Semen Ziziphi Spinosae 23 weight portion, Radix Polygalae 18 weight portion, Radix Pittospori Glabrati 33 weight portion, Herba Lythri Salicariae 23 weight portion, Herba Polygoni Perfoliati 9 weight portion and Herba Gnaphalii Affinis 28 weight portion.

For solving the problems of the technologies described above, the present invention also provides a kind of and treats the preparation method that the Chinese medicine of heart pulmonary type cardiac asthma disease insulted by drink, and wherein when the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps:

Step 1: first Rhizoma Arisaematis, Semen Sinapis Albae, Radix Kansui, Flos Inulae, Pumex, Fructus Perillae, Rhizoma Cynanchi Stauntonii, Radix Asteris, the Radix Euphorbiae Pekinensis, Bulbus Fritillariae Cirrhosae, Flos Farfarae and Bulbus Lilii are mixed in described ratio, distillation crystallization obtains powder;

Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;

In step 3, step 2 Chinese medicine slag is added 4-6 times amount water soaking 1-2.5 hour, heating decocts 1.5-2 hour, and filter, concentrated filtrate is extractum shape, is component 2;

Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.

For solving the problems of the technologies described above, the present invention also provides a kind of and treats the preparation method that the Chinese medicine of heart pulmonary type cardiac asthma disease insulted by drink, and wherein when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, Rhizoma Arisaematis, Semen Sinapis Albae, Radix Kansui, Flos Inulae and Pumex are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 60 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Fructus Perillae, Rhizoma Cynanchi Stauntonii, Radix Asteris, the Radix Euphorbiae Pekinensis, Bulbus Fritillariae Cirrhosae, Flos Farfarae, Bulbus Lilii, the Radix Astragali and Cortex Mori are mixed in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 75% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C ~ 70 DEG C reduced vacuum dryings are also pulverized, and get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

For solving the problems of the technologies described above, the present invention also provides a kind of and treats the preparation method that the Chinese medicine of heart pulmonary type cardiac asthma disease insulted by drink, and wherein when the dosage form of described Chinese medicine is drop, its preparation method comprises the following steps:

First all raw medicinal materials are distilled in described ratio blending water vapor method, obtain crystal; Then distillation test residue is put into the ethanol of 10 times amount 85% ~ 95%, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing, gets supernatant; The crystal of distillation extraction is put into filtrate, soaks 5-10 days; Reclaim ethanol, the medicinal liquid being less than 20% containing crude drug with distilled water furnishing.

For solving the problems of the technologies described above, the present invention reoffers a kind of drink for the treatment of and insults heart pulmonary type cardiac asthma fear and to be impairment of the kidney the dosage form of Chinese medicine preparation of card, and pharmaceutical dosage form can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, liniment, enema and patch.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: Chinese medicine of the present invention, utilize the theory of Chinese medical science that China is traditional, with warming YANG to promote diuresis, eliminating pathogen from the lung for relieving asthma is main, and cardiopulmonary card insulted by treatment cardiac asthma drink, there is significant therapeutic effect, further, Chinese herbal medicine is pure natural property, and toxic and side effects is less, can immunity of organisms be improved, not easily produce drug resistance; Processing technology of the present invention is easy, and medical material cost price is cheap, and through scientific compatibility, selected medical material, mouthfeel is suitable for, and patient is easy to accept.

Detailed description of the invention

"Nei Jing" has more discussion to breathing heavily disease.As " Ling Shu Miraculous Pivot or Divine Axis five is read five and made " is said: " therefore lung patient, dyspnea and flaring of nares." " Ling Shu Miraculous Pivot or Divine Axis this dirty " say: " lung height then goes up gas dyspneal cough." that to breathe heavily disease be main disease with lung is dirty in prompting, and with rapid breathing, flaring of nares, half the circumference of the sleeve where it joins the shoulder for feature." Ling Shu Miraculous Pivot or Divine Axis five pathogenic factors " is pointed out: " evil in lung, then sick dermatodynia, cold and heat, dyspnea due to adverse flow of lung-QI, sweating, dyspnea with shaking of the shoulders and the back." " Plain Questions lift pain opinion " add: " labor is then panted sweating." point out to breathe heavily the existing diseases caused by exogenous pathogenic factor of the disease cause of disease, also have internal injury, pathogenesis also has deficiency and excess not.In addition, " Plain Questions numbness opinion " cloud: " obstruction of heart-QI person, arteries and veins is obstructed, tired then severe palpitation, sudden and violent upper gas and breathing heavily." " Plain Questions passages through which vital energy circulates another matter " cloud; " pendant probably, is breathed heavily for liver to some extent." though prompting breathes heavily based on lung, also relates to that it is dirty.Chinese treatise on Febrile Diseases, " Medical Treasures of the Golden Chamber " have realized that numerous disease, as typhoid fever, consumptive lung disease, lung abscess, aqueous vapor, jaundice, asthenia all can cause breathing heavily disease, and start concrete decoction for the treatment.After gold dollar, many doctors have enriched that internal injury is all to be controlled because causing the card breathed heavily.As " danxi's experiential therapy is breathed heavily " is said: " institute of six climate exopathogens seven emotions is sad, action of being satiated with food, and visceral-qi is got along well, the breath of breathing, must not declare smooth and be dyspnea with rapid respiration.Also all empty weak people of spleen kidney are had, all can breathing heavily." recognize six climate exopathogens, seven emotions, injury due to diet, have a delicate constitution the cause of disease being all and breathing heavily disease.Ming Dynasty's Zhang Jingyue is summarized as deficiency and excess two card breathing heavily disease." Jing Yue's complete work, dyspnea with rapid and short breath " is said: " excess-dyspnea person has heresy, and excess of pathogen also; Dyspnea due to deficiency person naivete, first deficiency of vital energy also." indicate the dialectical guiding principle of breathing heavily disease." Linzheng Zhinan Yi is breathed heavily " is said clearly: " at lung for real, be empty at kidney." " Lei Zheng Zhi Cai asthma " then explicitly point out the Therapeutic Principle of " breathe heavily and control lung by diseases caused by exogenous pathogenic factor person, control kidney by interior the wounded ".

The Therapeutic Principle that motherland's medical science is thought controls by deficiency and excess opinion.Excess-dyspnea controls lung, controls with eliminating pathogen to activate QI.Cold, hot, expectorant, gas difference should be distinguished, adopt respectively Wen Xuan, respectful clearly, eliminate the phlegm, the method such as sending down the abnormal ascending QI.Dyspnea due to deficiency is controlled at lung kidney, based on kidney, controls with invigorating kidney QI to promote inspiration.For the pathogenesis of Zong-Fu diseases, adopt tonifying the lung, receive kidney, warming YANG, QI invigorating, yin nourishing, the method such as solid de-.Simulataneous insufficiency and excessive, deficiency in the lower and excess in the upper person, when knowing the secondary from the primary, balance specimen, suitably processes.

Therefore, the present invention is with warming YANG to promote diuresis, eliminating pathogen from the lung for relieving asthma is primary treatment principle, heart pulmonary type cardiac asthma insulted by treatment drink, selects prescription: Rhizoma Arisaematis, Semen Sinapis Albae, Radix Kansui, Flos Inulae, Pumex, Fructus Perillae, Rhizoma Cynanchi Stauntonii, Radix Asteris, the Radix Euphorbiae Pekinensis, Bulbus Fritillariae Cirrhosae, Flos Farfarae, Bulbus Lilii, the Radix Astragali, Cortex Mori, Pericarpium Arecae, Poria, Semen Lepidii (Semen Descurainiae), Semen Ginkgo, Fructus Schisandrae Chinensis, Herba Euphorbiae Helioscopiae, Semen Ziziphi Spinosae, Radix Polygalae, Radix Pittospori Glabrati, Herba Lythri Salicariae, Herba Polygoni Perfoliati and Herba Gnaphalii Affinis.

The invention provides a kind of Chinese medicine for the treatment of drink icepro heart pulmonary type cardiac asthma disease, wherein, following raw medicinal material is comprised: Rhizoma Arisaematis, Semen Sinapis Albae, Radix Kansui, Flos Inulae, Pumex, Fructus Perillae, Rhizoma Cynanchi Stauntonii, Radix Asteris, the Radix Euphorbiae Pekinensis, Bulbus Fritillariae Cirrhosae, Flos Farfarae, Bulbus Lilii, the Radix Astragali, Cortex Mori, Pericarpium Arecae, Poria, Semen Lepidii (Semen Descurainiae), Semen Ginkgo, Fructus Schisandrae Chinensis, Herba Euphorbiae Helioscopiae, Semen Ziziphi Spinosae, Radix Polygalae, Radix Pittospori Glabrati, Herba Lythri Salicariae, Herba Polygoni Perfoliati and Herba Gnaphalii Affinis.

Wherein, Rhizoma Arisaematis is warm in nature and dry, has the merit of stronger drying dampness to eliminate phlegm; Semen Sinapis Albae warming the lung for resolving phlegm, compatibility Fructus Perillae, Radix Kansui are with using; The capable aquation expectorant of Flos Inulae sending down the abnormal ascending QI, with Cortex Mori, Pumex compatibility with using; Rhizoma Cynanchi Stauntonii slightly warm in nature and not dry strong, is longer than and eliminates the phlegm, fall lung qi to relieving asthma, with Radix Asteris, the Radix Euphorbiae Pekinensis, Cortex Mori, Semen Lepidii (Semen Descurainiae), Radix Astragali compatibility with using; Bulbus Fritillariae Cirrhosae is cold in nature, mildly bitter flavor, can reduce phlegm by eliminating heat from the lung, again sweet in the mouth matter profit energy nourishing the lung to arrest cough; Flos Farfarae nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm, with Radix Asteris, Bulbus Lilii compatibility with using; Cortex Mori eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema, compatibility Poria, Pericarpium Arecae; Semen Lepidii (Semen Descurainiae) hardship is fallen pungent loose, heat clearing away cold in nature, and diseases caused by retention of fluid and phlegm-fire in special eliminating the pathogens from the lung and relievining asthma is coughed, and compatibility Cortex Mori, Radix Pittospori Glabrati, Herba Lythri Salicariae, Herba Polygoni Perfoliati are with using; Semen Ginkgo astringing lung-QI and dissipating phlegm Dingchuan, with Fructus Schisandrae Chinensis compatibility with using; Herba Euphorbiae Helioscopiae inducing diuresis to remove edema, preventing phlegm from forming and stopping coughing, compatibility Cortex Mori, Herba Gnaphalii Affinis are with using; Semen Ziziphi Spinosae nourish heart the liver benefiting, calm the nerves; Radix Polygalae calm the nerves beneficial will, eliminate the phlegm and have one's ideas straightened out, compatibility Bulbus Fritillariae Cirrhosae with use.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Rhizoma Arisaematis: bitter, pungent, temperature.Return lung, liver, spleen channel.Drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.For pertinacious phlegm cough, wind disease is dizzy, and middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus; Outer for carbuncle, snake bite and insect sting.

Semen Sinapis Albae: acrid in the mouth, temperature, nontoxic.Return the warp of liver, spleen, lung, stomach, the heart and collaterals of the uterus.Can remove cold air, settling five organs, by the expectorant of film diaphragm, ward off stealthy gas, the addiction that disappears malaria, drop interests Dingchuan, sharp key improving eyesight, and removing blood stasis relieves the pain, and all can prove effective.Can energy dissipating fall, energy complementary energy liter, helps all tonics, outstanding kind receipts merit.

Radix Kansui: bitter in the mouth, cold in nature.Return spleen channel, lung meridian, kidney channel, urinary bladder channel, large intestine channel, small intestine meridian.Removing water retention by purgation by swollen, dispersing swelling and dissipating binds.Cure mainly edema, ascites, prolonged fluid-retention blocked-up chest, epilepsy, breath with cough, sphincter disturbance.Radix Kansui can stimulate intestinal tube, increases enterokinesia, produces discharge function.

Flos Inulae: salty, warm.Return lung, liver, stomach warp.Function expectorant, the therapeutic method to keep the adverse QI flowing downwards, softening the hard mass, row water.Cure mainly expectorant knot in the heart, the lower distension of the side of body, cough with asthma, singultus, saliva as shellac varnish, epigastric oppression Ying, eructation unrelieved, extensive abdominal edema.

Pumex: salty, cold.Return lung, kidney, liver, large intestine channel.Lung heat clearing fire, changes old expectorant, relieving stranguria by diuresis, hard masses softening and resolving.Cure mainly phlegm-heat obstructing in the lung, the thick difficulty of cough with asthma expectorant is coughed up, the puckery pain of dribbling urination, goiter scrofula.

Fructus Perillae: pungent, temperature.Return lung, spleen channel.Can relieving the exterior syndrome by diaphoresis, regulating the flow of QI to ease the stomach, solving toxin of fish and crab.For anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen, fish Eriocheir sinensis is poisoning.Folium Perillae acrid in the mouth warm in nature, have induce sweat, cold expelling, the effect of regulating the flow of vital energy and seeking.Be applicable to the diseases such as cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen.

Rhizoma Cynanchi Stauntonii: pungent, bitter, tepor.Return lung meridian.Lowering the adverse-rising QI to resolve phlegm, cough-relieving.Cough with copious phlegm, asthma.Slightly warm in nature and not dry strong, is longer than and eliminates the phlegm, fall lung qi with flat cough with asthma.

Radix Asteris: warm in nature, bitter in the mouth, pungent.Nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing.Cure mainly cough, deficiency of the lung chronic cough, consumptive lung disease lung abscess, coughs vomiting bloody pus, dysuria.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.

The Radix Euphorbiae Pekinensis: bitter, cold.Return lung, spleen, kidney channel.Cure mainly edema distension, constipation and anuresis, all real persons of symptoms and signs.Also can be used for phlegm retention to gather, chest and diaphragm distension, side of body rib dull pain.

Bulbus Fritillariae Cirrhosae: the large hardship of taste, cold in nature.Return lung, the heart, stomach, Liver Channel.Control greatly lung abscess lung to wither, cough with asthma, spit blood, mental disorder, falls most in epistaxis, kind relieving stagnation, and relieve the pain pain, and relieving distension is full, clearing away liver-fire, improve visual and auditory acuity, except seasonal epidemic pathogens dysphoria with smothery sensation, and jaundice stranguria with urinary obstruction, hematuria of having blood in stool; Relieving heat toxin, kill parasites and treat sore throat, scrofula, acute mastitis carbuncle on the back, all carbuncle and ulcer toxic swellings, damp and hot malignant boil, anal fistula, incised wound is hemorrhage, burn pain.

Flos Farfarae: acrid in the mouth, warm in nature.Return lung meridian.Preventing phlegm from forming and stopping coughing.There is the antitussive therapeutic method to keep the adverse QI flowing downwards, the function that lung moistening is eliminated the phlegm.For cough, asthma, consumptive lung disease, coughs the diseases such as blood of spitting.

Bulbus Lilii: sweet, cold.GUIXIN, lung meridian.Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.

The Radix Astragali: sweet, tepor.Return lung, spleen, liver, kidney channel.The Radix Astragali, life consolidating superficial resistance, losslessly can send out, and has antiperspirant to stop; Process with invigorating middle warmer, beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person.

Cortex Mori: Gan Han.Return lung meridian.Expectorant is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, and kill abdomen and hide worm, only cholera is vomited and diarrhoea.Function eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.

Pericarpium Arecae: acrid in the mouth, slightly warm in nature.Return spleen, stomach, large intestine, small intestine meridian.Therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.For retention of damp leading to blockage of QI, breast abdominal distention is vexed, defecates not well, edema, beriberi, dysuria.

Poria: sweet, light is flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness.The sharp key of light energy, sweet with supporing yang, the panacea of dehumidifying also.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, inducing QI of promoting the production of body fluid.

Semen Lepidii (Semen Descurainiae): pungent, bitter, cold.Return lung meridian, heart channel, Liver Channel, stomach warp, urinary bladder channel.Function eliminating the pathogens from the lung sending down the abnormal ascending QI, eliminating phlegm and relieving asthma, inducing diuresis to remove edema, lets out by heresy.Cure mainly sputum stop up the dyspnea and cough with excessive sputum of lung, lung abscess, edema, breast abdomen hydrops, dysuria, chronic pulmonary heart disease, heart failure breathe heavily swollen, scrofula tuberculosis.

Semen Ginkgo: property is put down, sweet in the mouth is pained, slightly poisonous.Return lung, kidney channel.Astringe the lung gas, relieving asthma and cough, leukorrhagia stopping is turbid, urine reducing, disinfection.Cure mainly asthma, phlegmatic cough, nocturnal emission, leucorrhea, nebulousurine, infantile diarrhea, malnutrition due to parasitic infestation, hemorrhoidal hamorrhage dysentery, gonorrhea, frequent micturition, and the disease such as scabies, dermatitis rhus, in vain tumor wind.

Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet.Return lung, the heart, kidney channel.Have convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming, for chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, deficient pulse of losing heart, the cards such as interior-heat is quenched one's thirst, palpitation and insomnia.

Herba Euphorbiae Helioscopiae: cold nature, bitter in the mouth.Return large and small intestinal, spleen channel.Inducing diuresis to remove edema, dissipating phlegm and resolving masses, killing parasites for relieving itching.Breath with cough for ascites, edema, pulmonary tuberculosis, the tuberculosis of cervical lymph nodes, abundant expectoration, tinea skin ulcer.For extensive abdominal edema, the extremity edema of the face.This product purging with bitter and cold drugs, has stronger inducing diuresis to remove edema effect.

Semen Ziziphi Spinosae: sweet, sour, property is put down.GUIXIN warp, spleen channel, Liver Channel, gallbladder meridian.Main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong.

Radix Polygalae: bitter, pungent, tepor.GUIXIN, kidney, lung meridian.To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence insomnia and dreamful sleep, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.Epilepsy mania and irritation, spasm is twitched, skin sore.

Radix Pittospori Glabrati: sweetness and bitterness is pungent is cool.Tonifying the lung kidney, wind-damp dispelling, promoting blood circulation to remove obstruction in the collateral.Control asthenia to breath with cough, seminal emission premature ejaculation, insomnia, dizzy, hypertension, rheumatic arthralgia, infantile paralysis.

Herba Lythri Salicariae: bitter, cold.Large intestine, Liver Channel.Heat-clearing and toxic substances removing; Astringing to arrest bleeding.Main dysentery; Have loose bowels; Have blood in stool; Metrorrhagia; Skin infection festers; Spit blood; Epistaxis; Traumatic hemorrhage.

Herba Polygoni Perfoliati: acid; Bitter; Property is put down.Lung; Small intestine meridian.Heat-clearing and toxic substances removing; Inducing diuresis and reducing edema; Dissipating blood stasis stops blooding.Main furuncle carbuncle; Erysipelas; The paralysis cheek; Mastitis; Ting ear; Throat moth; Cold, fever; Cough due to lung-heat; Pertussis; Scrofula; Haemorrhoids; Lymphogranuloma inguinale inguinal bubo; Dysentery; Jaundice; Tympanites; Edema; Stranguria with turbid discharge; Leukorrhagia; Malaria; Wind-fire acute conjunctivitis; Treating swelling and pain by traumatic injury; Spit blood; Have blood in stool; Snake bite and insect sting.

Herba Gnaphalii Affinis: sweet in the mouth; Micro-acid; Property is put down.Return lung meridian.Preventing phlegm from forming and stopping coughing; Expelling wind and removing dampness; Removing toxic substances.Main cough with asthma abundant expectoration; Rheumatic arthralgia; Have loose bowels; Edema; Favism; Leucorrhea with red and white discharge; Carbuncle furuncle; Scrotum pruritus due to damp pathogen; Urticaria; Hypertension.

For solving the problems of the technologies described above, the present invention reoffers and a kind ofly treats the dosage form that the Chinese medicine preparation of heart pulmonary type cardiac asthma insulted by drink, and pharmaceutical dosage form can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, liniment, enema and patch.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 honey refining of the present invention pill

Get Rhizoma Arisaematis 4g, Semen Sinapis Albae 10g, Radix Kansui 5g, Flos Inulae 6g, Pumex 19g, Fructus Perillae 31g, Rhizoma Cynanchi Stauntonii 7g, Radix Asteris 13g, Radix Euphorbiae Pekinensis 3g, Bulbus Fritillariae Cirrhosae 39g, Flos Farfarae 16g, Bulbus Lilii 22g, Radix Astragali 27g, Cortex Mori 17g, Pericarpium Arecae 18g, Poria 35g, Semen Lepidii (Semen Descurainiae) 27g, Semen Ginkgo 39g, Fructus Schisandrae Chinensis 26g, Herba Euphorbiae Helioscopiae 4g, Semen Ziziphi Spinosae 32g, Radix Polygalae 13g, Radix Pittospori Glabrati 27g, Herba Lythri Salicariae 29g, Herba Polygoni Perfoliati 20g and Herba Gnaphalii Affinis 33g.

Its preparation method comprises the following steps:

Step 2: get surplus stock medical material again and mix in described ratio, add 94% soak with ethanol 2 hours, the heating extraction 2 times relative to mixture 6 times amount, each 1 hour, merge extractive liquid, 124 orders filter, be the ultrafiltration post ultrafiltration of 98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;

In step 3, step 2 Chinese medicine slag is added 4 times amount water soaking 1 hour, heating decoction 1.5 hours, filter, concentrated filtrate is extractum shape, is component 2;

Embodiment 2 capsule of the present invention

Get Rhizoma Arisaematis 6g, Semen Sinapis Albae 23g, Radix Kansui 10g, Flos Inulae 11g, Pumex 30g, Fructus Perillae 29g, Rhizoma Cynanchi Stauntonii 6g, Radix Asteris 21g, Radix Euphorbiae Pekinensis 8g, Bulbus Fritillariae Cirrhosae 27g, Flos Farfarae 25g, Bulbus Lilii 20g, Radix Astragali 25g, Cortex Mori 27g, Pericarpium Arecae 13g, Poria 27g, Semen Lepidii (Semen Descurainiae) 19g, Semen Ginkgo 29g, Fructus Schisandrae Chinensis 30g, Herba Euphorbiae Helioscopiae 11g, Semen Ziziphi Spinosae 24g, Radix Polygalae 21g, Radix Pittospori Glabrati 23g, Herba Lythri Salicariae 16g, Herba Polygoni Perfoliati 10g and Herba Gnaphalii Affinis 21g.

Its preparation method comprises the following steps:

The first step, Rhizoma Arisaematis, Semen Sinapis Albae, Radix Kansui, Flos Inulae and Pumex are mixed in described ratio, add the water extraction volatile oil relative to 4 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1:6, stirs 60 minutes, temperature 50 C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.17;

Second step, Fructus Perillae, Rhizoma Cynanchi Stauntonii, Radix Asteris, the Radix Euphorbiae Pekinensis, Bulbus Fritillariae Cirrhosae, Flos Farfarae, Bulbus Lilii, the Radix Astragali and Cortex Mori are mixed in described ratio, add relative to mixture 5 times amount determining alcohol be 75% alcohol reflux 3 times, each 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 times of water gagings, boil 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.30;

4th step, the clear paste of the first step, second step, the 3rd step mixed 70 DEG C of reduced vacuum dryings and pulverize, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 weight portion carboxymethyl starch sodium, 15 weight starch mix homogeneously, adding 200 weight portion determining alcohols is 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 weight portion magnesium stearate, then load in gelatine capsule.

Embodiment 3 drop of the present invention

Get Rhizoma Arisaematis 5g, Semen Sinapis Albae 13g, Radix Kansui 8g, Flos Inulae 7g, Pumex 22g, Fructus Perillae 21g, Rhizoma Cynanchi Stauntonii 13g, Radix Asteris 17g, Radix Euphorbiae Pekinensis 6g, Bulbus Fritillariae Cirrhosae 35g, Flos Farfarae 13g, Bulbus Lilii 30g, Radix Astragali 34g, Cortex Mori 19g, Pericarpium Arecae 28g, Poria 31g, Semen Lepidii (Semen Descurainiae) 16g, Semen Ginkgo 38g, Fructus Schisandrae Chinensis 20g, Herba Euphorbiae Helioscopiae 9g, Semen Ziziphi Spinosae 23g, Radix Polygalae 18g, Radix Pittospori Glabrati 33g, Herba Lythri Salicariae 23g, Herba Polygoni Perfoliati 9g and Herba Gnaphalii Affinis 28g.

Its preparation method comprises the following steps:

First by all raw medicinal material blending water vapor method distillations, obtain crystal; Then distillation test residue is put into the ethanol of 10 times amount 85%, heating and refluxing extraction 2 times, each 2 hours, extract active ingredient, 2 extracting solution are merged filtering and standing, gets supernatant; The crystal of distillation extraction is put into filtrate, soaks 10 days; Reclaim ethanol, containing crude drug with distilled water furnishing is the medicinal liquid of 10%.

Toxicity test:

Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The honey refining pill prepared by embodiments of the invention 1 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage honey refining of the present invention pill LD50>28.7 crude drug/kg, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore the honey refining pill acute toxicity of the embodiment of the present invention 1 is low, clinical drug safety.

Long term toxicity test: the capsule of the embodiment of the present invention 2 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Long term toxicity test: the drop of the embodiment of the present invention 3 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: choose the 155 example drinks that my institute accepts for medical treatment and insult heart pulmonary type cardiac asthma persons, male 95 people, female 60 people, age 31-72 year, 56 years old mean age, hypertensive heart disease 82 example, coronary heart disease 38 example, high coronary heart disease 22 example, cardiomyopathy 13 example, the course of disease 15 days-16 years; Be divided at random:

Honey refining pill treatment group: 38 people, male 23 people, female 15 people.

Capsule treatment group: 39 people, male 24 people, female 15 people.

Drop treatment group: 39 people, male 24 people, female 15 people.

Western medicine group: 39 people, male 24 people, female 15 people.

Diagnostic criteria:

1, with dyspnea with rapid and short breath QI rising in reverse order, dyspnea, even opening mouth and lifting shoulder due to dyspnea, flaring of nares, can not put down sleeping, and lip cyanosis is feature.

2, there are the medical histories such as chronic cough, bronchial wheezing, pulmonary tuberculosis, cardiopalmus, whenever diseases caused by exogenous pathogenic factor and tired and bring out more.

3, two lung audibles and dry moist sound of vomiting sound or wheezing sound.

4, lab testing support causes dyspnea, the diagnosis of the doctor trained in Western medicine diseases related of dyspnea with rapid and short breath, and as pulmonary infection has blood leukocytes sum and neutrophilic granulocyte to raise, or x line rabat has increase in the lung markings or has the foundations such as lamellar shade

Therapeutic Method:

Conventional heart tonifying, diuresis, blood vessel dilating, relieving asthma, symptomatic treatment, on this basis,

Honey refining pill treatment group: add the honey refining pill taken the embodiment of the present invention 1 and prepare, every day 3 times, each 47 days is 1 course for the treatment of.

Capsule treatment group: add the capsule taken the embodiment of the present invention 2 and prepare, every day 3 times, each 47 days is 1 course for the treatment of.

Drop treatment group: add the drop dripping and prepare by the embodiment of the present invention 3, every day 4 times, each 36 days is 1 course for the treatment of.

Western medicine group: add and add slowly intravenous drip in normal saline 20 m l with phentolamine 5 mg, no matter whether noted, dyspnea alleviate or systolic pressure comparatively before medication decline 5-10mmHg namely stop, changing phentolamine 10-20 mg into adds in 5% glucose 250 ml, / m in intravenous drip maintenance is dripped with 8-12, once a day, within 6 days, be 1 course for the treatment of.

Efficacy assessment standard:

Effective: paroxysmal dyspnea during nighttime sleep, cough, spitting of blood expectorant disappear, pulmonary's wheezing sound, moist rale transference cure, and heart rate is normal, and Chest X-rays pulmonary congestion levies disappearance, ultrasonic cardiography diagram cardiac function comparatively before as well;

Effective: symptom obviously alleviates, heart rate decline, pulmonary's moist rale obviously reduces, Chest X-rays and ultrasoundcardiogram before comparatively controlling as well;

Invalid: symptom and lab testing improve not obvious.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs of the present invention to drink and insult heart pulmonary type cardiac asthma, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs of the present invention to drink and insult heart pulmonary type cardiac asthma, relative to Western medicine, treatment course for the treatment of significantly shortens.

Table 1 Four composition does not treat Clinical efficacy comparison example after 28 days

Group	Number of cases	Effective	Effectively	Invalid	Total effective rate
						Honey refining pill treatment group	38	34	4	0	100%
Capsule treatment group	39	35	4	0	100%
						Drop treatment group	39	35	4	0	100%
Western medicine group	39	29	6	4	89.7%

Table 2 Four composition does not treat effective and effective number and time comparative example (%) after 28 days

Group	Number of cases	1-10 days	11-20 days	21-28 days
					Honey refining pill treatment group	38	8(21.1%)	25(65.8%)	5(13.2%)
Capsule treatment group	39	10(25.6%)	22(56.4%)	7(17.9%)
					Drop treatment group	39	9(23.1%)	26(66.7%)	4(10.3%)
Western medicine group	35	2(5.7%)	18(51.4%)	15(42.9%)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Simultaneously to effective and effective 38 examples of honey refining pill treatment group, effective and effective 39 examples of capsule treatment group, drop treatment group effective and effective 39 is routine, and the effective and effective 35 routine follow-up of patients of western medicine group 2 years, result statistics:

Effective and effective 38 examples of honey refining pill treatment group, 34 effective example recurrence 3 examples, 1 case relapsed in effective 4 routine patients, relapse rate is 10.5%;

Effective and effective 39 examples of capsule treatment group, 35 effective example recurrence 4 examples, 1 case relapsed in effective 4 routine patients, relapse rate is 12.8%;

Effective and effective 39 examples of drop treatment group, 35 effective example recurrence 3 examples, 1 case relapsed in effective 4 routine patients, relapse rate is 10.3%;

Effective and effective 35 examples of western medicine group, 29 effective example recurrence 9 examples, recur 5 examples in effective 6 routine patients, relapse rate is 40%.

Model case: grandson patient, man, 48 years old, precordialgia 36 hours, increases the weight of 5 hours in people institute July 14 in 2012, for inferior myocardial infarction of super acute injury phase in early days, sinus bradycardia, companion's cough, spitting of blood expectorant, there is wheezing sound in pulmonary, and two base of lung has moist rale; Breath with cough QI rising in reverse order, resting on the bedstead to sleep is difficult to flat sleeping, coughs up thin and whitish sputum, cardiopalmus, appearance limbs edema, and urine amount is few, and timid cold cold extremities, cyanosis on the face and lips, enlarged tongue is dim, white, slippery and moist fur, deep-thready pulse.Be diagnosed as drink and insult heart pulmonary type cardiac asthma.Take the capsule of Chinese medicine preparation embodiment 2 of the present invention, every day 3 times, each 4, treat 14 days effective, continue to take medicine 7 days, follow up a case by regular visits to and do not recur for 2 years.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the Chinese medicine that heart pulmonary type cardiac asthma insulted by drink for one kind, it is characterized in that, comprise following raw medicinal material: Rhizoma Arisaematis, Semen Sinapis Albae, Radix Kansui, Flos Inulae, Pumex, Fructus Perillae, Rhizoma Cynanchi Stauntonii, Radix Asteris, the Radix Euphorbiae Pekinensis, Bulbus Fritillariae Cirrhosae, Flos Farfarae, Bulbus Lilii, the Radix Astragali, Cortex Mori, Pericarpium Arecae, Poria, Semen Lepidii (Semen Descurainiae), Semen Ginkgo, Fructus Schisandrae Chinensis, Herba Euphorbiae Helioscopiae, Semen Ziziphi Spinosae, Radix Polygalae, Radix Pittospori Glabrati, Herba Lythri Salicariae, Herba Polygoni Perfoliati and Herba Gnaphalii Affinis.

2. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma Arisaematis 4-9 weight portion, Semen Sinapis Albae 10-28 weight portion, Radix Kansui 5-12 weight portion, Flos Inulae 6-13 weight portion, Pumex 17-34 weight portion, Fructus Perillae 21-38 weight portion, Rhizoma Cynanchi Stauntonii 6-18 weight portion, Radix Asteris 13-26 weight portion, Radix Euphorbiae Pekinensis 3-10 weight portion, Bulbus Fritillariae Cirrhosae 25-43 weight portion, Flos Farfarae 11-29 weight portion, Bulbus Lilii 18-34 weight portion, Radix Astragali 23-37 weight portion, Cortex Mori 14-29 weight portion, Pericarpium Arecae 10-30 weight portion, Poria 23-37 weight portion, Semen Lepidii (Semen Descurainiae) 16-31 weight portion, Semen Ginkgo 26-42 weight portion, Fructus Schisandrae Chinensis 17-34 weight portion, Herba Euphorbiae Helioscopiae 3-13 weight portion, Semen Ziziphi Spinosae 20-35 weight portion, Radix Polygalae 13-29 weight portion, Radix Pittospori Glabrati 20-36 weight portion, Herba Lythri Salicariae 14-31 weight portion, Herba Polygoni Perfoliati 9-23 weight portion and Herba Gnaphalii Affinis 19-36 weight portion.

3. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma Arisaematis 4-7 weight portion, Semen Sinapis Albae 10-23 weight portion, Radix Kansui 5-10 weight portion, Flos Inulae 6-11 weight portion, Pumex 19-30 weight portion, Fructus Perillae 21-31 weight portion, Rhizoma Cynanchi Stauntonii 6-13 weight portion, Radix Asteris 13-21 weight portion, Radix Euphorbiae Pekinensis 3-8 weight portion, Bulbus Fritillariae Cirrhosae 27-39 weight portion, Flos Farfarae 13-25 weight portion, Bulbus Lilii 20-30 weight portion, Radix Astragali 25-34 weight portion, Cortex Mori 17-27 weight portion, Pericarpium Arecae 13-28 weight portion, Poria 27-35 weight portion, Semen Lepidii (Semen Descurainiae) 16-27 weight portion, Semen Ginkgo 29-39 weight portion, Fructus Schisandrae Chinensis 20-30 weight portion, Herba Euphorbiae Helioscopiae 4-11 weight portion, Semen Ziziphi Spinosae 23-32 weight portion, Radix Polygalae 13-21 weight portion, Radix Pittospori Glabrati 23-33 weight portion, Herba Lythri Salicariae 16-29 weight portion, Herba Polygoni Perfoliati 9-20 weight portion and Herba Gnaphalii Affinis 21-33 weight portion.

4. the Chinese medicine according to any one of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma Arisaematis 4 weight portion, Semen Sinapis Albae 10 weight portion, Radix Kansui 5 weight portion, Flos Inulae 6 weight portion, Pumex 19 weight portion, Fructus Perillae 31 weight portion, Rhizoma Cynanchi Stauntonii 7 weight portion, Radix Asteris 13 weight portion, the Radix Euphorbiae Pekinensis 3 weight portion, Bulbus Fritillariae Cirrhosae 39 weight portion, Flos Farfarae 16 weight portion, Bulbus Lilii 22 weight portion, the Radix Astragali 27 weight portion, Cortex Mori 17 weight portion, Pericarpium Arecae 18 weight portion, Poria 35 weight portion, Semen Lepidii (Semen Descurainiae) 27 weight portion, Semen Ginkgo 39 weight portion, Fructus Schisandrae Chinensis 26 weight portion, Herba Euphorbiae Helioscopiae 4 weight portion, Semen Ziziphi Spinosae 32 weight portion, Radix Polygalae 13 weight portion, Radix Pittospori Glabrati 27 weight portion, Herba Lythri Salicariae 29 weight portion, Herba Polygoni Perfoliati 20 weight portion and Herba Gnaphalii Affinis 33 weight portion.

5. according to the arbitrary described Chinese medicine of claim 1-4, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma Arisaematis 6 weight portion, Semen Sinapis Albae 23 weight portion, Radix Kansui 10 weight portion, Flos Inulae 11 weight portion, Pumex 30 weight portion, Fructus Perillae 29 weight portion, Rhizoma Cynanchi Stauntonii 6 weight portion, Radix Asteris 21 weight portion, the Radix Euphorbiae Pekinensis 8 weight portion, Bulbus Fritillariae Cirrhosae 27 weight portion, Flos Farfarae 25 weight portion, Bulbus Lilii 20 weight portion, the Radix Astragali 25 weight portion, Cortex Mori 27 weight portion, Pericarpium Arecae 13 weight portion, Poria 27 weight portion, Semen Lepidii (Semen Descurainiae) 19 weight portion, Semen Ginkgo 29 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Herba Euphorbiae Helioscopiae 11 weight portion, Semen Ziziphi Spinosae 24 weight portion, Radix Polygalae 21 weight portion, Radix Pittospori Glabrati 23 weight portion, Herba Lythri Salicariae 16 weight portion, Herba Polygoni Perfoliati 10 weight portion and Herba Gnaphalii Affinis 21 weight portion.

6. according to the arbitrary described Chinese medicine of claim 1-4, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma Arisaematis 5 weight portion, Semen Sinapis Albae 13 weight portion, Radix Kansui 8 weight portion, Flos Inulae 7 weight portion, Pumex 22 weight portion, Fructus Perillae 21 weight portion, Rhizoma Cynanchi Stauntonii 13 weight portion, Radix Asteris 17 weight portion, the Radix Euphorbiae Pekinensis 6 weight portion, Bulbus Fritillariae Cirrhosae 35 weight portion, Flos Farfarae 13 weight portion, Bulbus Lilii 30 weight portion, the Radix Astragali 34 weight portion, Cortex Mori 19 weight portion, Pericarpium Arecae 28 weight portion, Poria 31 weight portion, Semen Lepidii (Semen Descurainiae) 16 weight portion, Semen Ginkgo 38 weight portion, Fructus Schisandrae Chinensis 20 weight portion, Herba Euphorbiae Helioscopiae 9 weight portion, Semen Ziziphi Spinosae 23 weight portion, Radix Polygalae 18 weight portion, Radix Pittospori Glabrati 33 weight portion, Herba Lythri Salicariae 23 weight portion, Herba Polygoni Perfoliati 9 weight portion and Herba Gnaphalii Affinis 28 weight portion.

7. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps:

Step 3: step 2 Chinese medicine slag is added 4-6 times amount water soaking 1-2.5 hour, heating decocts 1.5-2 hour, and filter, concentrated filtrate is extractum shape, is component 2;

8., according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

9. the Chinese medicine according to any one of claim 1-6, is characterized in that, when the dosage form of described Chinese medicine is drop, its preparation method comprises the following steps: