CN105267815A - Spray for treating infant lung-kidney-deficiency type asthma and preparing method thereof - Google Patents

Spray for treating infant lung-kidney-deficiency type asthma and preparing method thereof Download PDF

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CN105267815A
CN105267815A CN201510878682.0A CN201510878682A CN105267815A CN 105267815 A CN105267815 A CN 105267815A CN 201510878682 A CN201510878682 A CN 201510878682A CN 105267815 A CN105267815 A CN 105267815A
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radix
herba
powder
spray
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刘今晓
吴姗姗
王茜
宋毅斐
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Wang Qian
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Abstract

The invention discloses a spray for treating infant lung-kidney-deficiency type asthma and a preparing method thereof. The spray is prepared from asarum caudigerellum, wild walnut kernels, asarum himalaicum, aster fastigiatus, polemonium caeruleum, liquorice, wild ginger, lacebark pine cones, wolfberry fruits, rhizoma polygonati, herba pyrolae, diaphragma juglandis, frog orchid tubers, astragalus membranaceus, acanthopanax roots, themeda triandra fruits, oat grass, rhodiola rosea, radix ranunculi ternate, Chinese dates, Chinese lizardtail rhizomes, menyanthes trifoliate, junci medulla, spina date seeds, polygala tenuifolia, radix stemonae, rauvolfia verticillate, rhizoma anemarrhenae and orchis. The spray has the advantages that the medicinal materials are used for treating infant lung-kidney-deficiency type asthma, and has the effects of warming the lung, eliminating phlegm, tonifying the kidney, securing the exterior, tonifying qi, calming the nerve, decreasing internal heat and strengthening the heart; due to basic scientific nursing, the effect is good, effect taking is rapid, replasing is not prone to occurrence, toxic and side effects are avoided, the spray is quite suitable for being taken by the infant age group.

Description

A kind ofly treat spray of Lungs of Children kidney deficiency asthma and preparation method thereof
Technical field
The present invention relates to tcm field, particularly a kind ofly treat spray of Lungs of Children kidney deficiency asthma and preparation method thereof.
Background technology
Asthma is one of common respiratory tract disease of department of pediatrics.Think that asthma is the diseases associated with inflammation that a kind of chronic airway continues at present, many cells play an important role wherein, as lymphocyte, eosinophilic granulocyte, mastocyte etc., and increase with non-specific airway significant reaction, the one being main clinical characteristics with the high response of air flue is many because of property disease.Main manifestations is panted and coughing fit for repeatedly reversible clinically, uncomfortable in chest, dyspnea, and these symptoms are often reversible, but also Weight variable is even lethally dies.Therefore to the control of asthma should with attention.Child is as a special age level, and each health is all in growth and stage of development, and the reversible and repeated relapsing of asthma, a lot of adverse effects is created to the daily of child.
Chinese medical discrimination is thought, asthma can be divided into wind-cold tightening the lung type according to disease: dyspnea with rapid respiration is uncomfortable in chest, and cough with copious phlegm is rare clearly, with fever with aversion to cold, and the diseases such as headache.Thin white fur of tongue, floating and tense pulse.Wind-heat invading the lung: dyspnea with rapid and short breath is rough, cough expectorant is yellow and sticky, and ambition is unhappy, xerostomia and thirsty, can have fever and aversion to wind.Red tongue margin, yellow and thin fur, floating and rapid pulse.Phlegm dampness in lungs: breath with cough uncomfortable in chest, abundant expectoration is easily coughed up, expectorant sticky or cough up tell not well, close in the heart, greasy taste in the mouth, gastral cavity painful abdominal mass abdominal distention.Pale tongue, white and greasy fur, stringy and rolling pulse.The heart attacked by pathogenic water: asthma breath gushes, and abundant expectoration show bubble, fullness in the chest can not be put down sleeping, limbs edema, severe palpitation, oliguria cold extremities, white and slippery fur, stringy,thready and rapid pulse.Deficiency of both lung and spleen: pant very brief unable, faint low voice, spontaneous perspiration cardiopalmus, pale complexion, spiritlessness and weakness, lack of appetite is the pool just, and light red tongue tongue is few, weak pulse.Or dry mouth and throat, red tongue, thready pulse.Deficiency of both the lung and kidney: with the passing of time, severe palpitation, dynamic then breath with cough, shortness of breath, uncomfortable in chestly can not put down sleeping as stopped up, abundant expectoration and gluing, or dysphoria and insomnia, cyanosis of the lips and nails in dyspnea with rapid and short breath.Body of the tongue is purple or red tongue tongue is few, faint pulse disease or knot, generation.Deficiency of both lung and spleen: pant very brief unable, faint low voice, spontaneous perspiration cardiopalmus, pale complexion, spiritlessness and weakness, lack of appetite is the pool just, and light red tongue tongue is few, weak pulse.Or dry mouth and throat, red tongue, thready pulse.
According to Chinese medical discrimination, can treat to the ill according to different diseases.But, because child is as a specific group, in medication and treatment, have very large difference.Therefore, how finding the effective medicine carrying out treating for Lungs of Children kidney deficiency asthma, is the problem to be solved in the present invention.
Summary of the invention
In order to solve the problem, the invention provides and a kind ofly treat spray of Lungs of Children kidney deficiency asthma and preparation method thereof.
In order to realize foregoing invention object, the invention provides a kind of spray for the treatment of Lungs of Children kidney deficiency asthma, wherein, being obtained by the raw medicinal material of following mass fraction: connect gas grass 10-20 weight portion, Semen juglandis cathayensis 13-25 weight portion, water Herba Asari 8-12 weight portion, Herba Turczaninowiae Fastigiatae 8-15 weight portion, Radix Polemonii Liniflori 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, Herba Asari Forbesii 6-10 weight portion, Strobilus Pini 6-12 weight portion, Fructus Lycii 8-13 weight portion, Rhizoma Polygonati 5-8 weight portion, Herba Pyrolae 9-15 weight portion, Partition in Fructus Juglandis 4-9 weight portion, Radix Habenariae Delavayi 5-8 weight portion, Radix Astragali 10-15 weight portion, Radix Et Caulis Acanthopanacis Senticosi 5-7 weight portion, Herba Themedae japonicae fruit 7-12 weight portion, Herba avenae fatuae 5-12 weight portion, Radix Rhodiolae 3-8 weight portion, Radix Ranunculi Ternati 4-8 weight portion, Fructus Jujubae 6-12 weight portion, Rhizoma Saururi 10-15 weight portion, Herba menyanthis 3-7 weight portion, Medulla Junci 7-12 weight portion, Semen Ziziphi Spinosae 6-10 weight portion, Radix Polygalae 10-14 weight portion, Radix Stemonae 2-4 weight portion, Radix Rauvolfiae 1-3 weight portion, Rhizoma Anemarrhenae 5-9 weight portion and Herba Orchidis Latifoliae 6-10 weight portion.
Wherein, the raw medicinal material of following mass fraction is had to obtain: to connect gas grass 15 weight portions, Semen juglandis cathayensis 18 weight portion, water Herba Asari 10 weight portion, Herba Turczaninowiae Fastigiatae 12 weight portion, Radix Polemonii Liniflori 12 weight portion, Radix Glycyrrhizae 17 weight portion, Herba Asari Forbesii 7 weight portion, Strobilus Pini 10 weight portion, Fructus Lycii 10 weight portion, Rhizoma Polygonati 7 weight portion, Herba Pyrolae 13 weight portion, Partition in Fructus Juglandis 5 weight portion, Radix Habenariae Delavayi 6 weight portion, the Radix Astragali 13 weight portion, Radix Et Caulis Acanthopanacis Senticosi 6 weight portion, Herba Themedae japonicae fruit 10 weight portions, Herba avenae fatuae 8 weight portion, Radix Rhodiolae 6 weight portion, Radix Ranunculi Ternati 6 weight portion, Fructus Jujubae 8 weight portion, Rhizoma Saururi 12 weight portion, Herba menyanthis 6 weight portion, Medulla Junci 8 weight portion, Semen Ziziphi Spinosae 8 weight portion, Radix Polygalae 12 weight portion, the Radix Stemonae 3 weight portion, Radix Rauvolfiae 2 weight portion, the Rhizoma Anemarrhenae 7 weight portion and Herba Orchidis Latifoliae 8 weight portion.
In order to achieve the above object, present invention also offers the preparation method of described spray, wherein, its preparation method comprises the following steps:
The first step, by Radix Glycyrrhizae, Medulla Junci and the careless crushed into powder a that sleeps;
All the other raw medicinal materials described are mixed in proportion by second step, add the water soaking 1-2 hour of 3 ~ 5 times amount, then decoct 2 times, first time decocts 1 ~ 2 hour, filters out filtrate, the water adding the 1-3 times amount of medicinal residues carries out second time again and decocts 0.5-1 hour, again filters out filtrate; Twice filtrate is merged, add determining alcohol be 80% ~ 90% ethanol to the concentration of medicinal liquid be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and dry also pulverizing obtains powder b, is mixed by powder b obtain mixed-powder with powder a, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;
3rd step, the determining alcohol that the mixed-powder that second step sterilizing obtains is joined 2 ~ 3 times of quality is the ethanol of 60% ~ 70%, airtight placement 24h ~ 48h, evenly moistening, be placed in percolation vat, the determining alcohol again adding mixed-powder 1 ~ 2 times of quality obtained relative to second step is place 24h ~ 48h after the ethanol of 75% ~ 80%, with the diafiltration of 3 ~ 5ml/min speed, collects percolate; Extrude the medicinal liquid of balance in percolation vat, merge with above-mentioned percolate, leave standstill, clarified supernatant, filter, be concentrated into the spray that crude drug concentration is 2g/ml.
The invention has the beneficial effects as follows: medicine of the present invention, treatment Lungs of Children kidney deficiency asthma, there is effect of warming the lung to eliminate phlegm, Bushen Gubiao, invigorating QI and tranquilization and pathogenic fire reducing heart tonifying, by nursing one's health the science of matrix, effective, curative effect is fast, not easily recurs, and have no side effect, the patient being well suited for children's's age bracket takes.
Detailed description of the invention
The invention provides a kind of spray for the treatment of Lungs of Children kidney deficiency asthma, wherein, following raw medicinal material is comprised: connect gas grass, Semen juglandis cathayensis, water Herba Asari, Herba Turczaninowiae Fastigiatae, Radix Polemonii Liniflori, Radix Glycyrrhizae, Herba Asari Forbesii, Strobilus Pini, Fructus Lycii, Rhizoma Polygonati, Herba Pyrolae, Partition in Fructus Juglandis, Radix Habenariae Delavayi, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Herba Themedae japonicae fruit, Herba avenae fatuae, Radix Rhodiolae, Radix Ranunculi Ternati, Fructus Jujubae, Rhizoma Saururi, Herba menyanthis, Medulla Junci, Semen Ziziphi Spinosae, Radix Polygalae, the Radix Stemonae, Radix Rauvolfiae, the Rhizoma Anemarrhenae and Herba Orchidis Latifoliae.Ingredients scientific matching, reaches the object for the treatment of Lungs of Children kidney deficiency asthma, has good effect.
The pharmacology of various raw medicinal material is as follows:
Connect gas grass: [nature and flavor] are pungent; Bitter; Temperature.[return through] lung; Stomach warp.[function cures mainly] expelling wind and cold; Warming the lung for resolving phlegm; Pain relieving.Main headche due to wind-cold; Phlegm retention cough with asthma; Cold syndrome of the stomach pain; Stomachache; Toothache; Rheumatic arthralgia; Traumatic injury.
Semen juglandis cathayensis: [nature and flavor] are warm in nature flat, sweet in the mouth.[function cures mainly] kernel: function invigorating QI and blood, moistening the lung and resolving the phlegm, the beneficial gate of vitality, profit three is burnt, warming the lung intestine moistening.Control deficiency and coldness cough, lower limb are ached.Oil: be laxation agent, can cestode be driven away: skin scabies is controlled in external, chilblain, bromhidrosis.
Water Herba Asari: [nature and flavor] are pungent; Temperature.[return through] lung; The heart; Small intestinal; Kidney; Stomach warp.[function cures mainly] dispersing wind-cold; Warming the lung to resolve fluid-retention; Regulating QI to relieve pain.Main headche due to wind-cold; Toothache; Rheumatic arthralgia; Phlegm retention is breathed with cough; Gastral cavity abdomen stagnation of QI distending pain.
Herba Turczaninowiae Fastigiatae: [nature and flavor] are " herbal classic " 1.: " acrid in the mouth, temperature." 2. " not Lu ": " be nontoxic." [function cures mainly] warming the lung for resolving phlegm, and in, diuresis.Control cough and asthma, borborygmus are suffered from diarrhoea, and dysentery, oliguria is puckery.1. " herbal classic ": " main air is cold to be washed, and cholera lets out dysentery, and borborygmus are variable place up and down, infantile convulsion, cold and heat hundred disease." 2. " not Lu ": " be treated lung and is hindered cough with dyspnea, perspires, trembles with fear for a long time at bladder, distention and fullness, food morbidity at night of drinking." 3. " Hunan medicine will ": " warming the lung therapeutic method to keep the adverse QI flowing downwards, relieving cough and resolving phlegm, diuresis."
Radix Polemonii Liniflori: [nature and flavor] " Inner Mongol Chinese herbal medicine ": " bitter, flat." [function cures mainly] eliminates the phlegm, hemostasis, calm.Control acute and chronic bronchitis, gastric hemorrhage, hemoptysis, epistaxis, metrorrhagia, epilepsy is had a sleepless night, menorrhagia.1. " Jilin Chinese herbal medicine ": " eliminate the phlegm, hemostasis, calm.Control abundant expectoration cough, epilepsy is had a sleepless night, menorrhagia." 2. " Chinese herbal medicine handbook is commonly used in Heilungkiang ": " controls acute and chronic bronchitis, hemoptysis, and spit blood, epistaxis, has blood in stool, metrorrhagia."
Radix Glycyrrhizae: [nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Herba Asari Forbesii: [nature and flavor] " not Lu ": " acrid in the mouth, temperature, nontoxic." [function cures mainly] loose wind by cold, expectorant row water, invigorate blood circulation, relieving asthma, analgesic therapy, control anemofrigid cold, breath with cough, edema, rheumatism, traumatic injury, headache, caries pain, and eruptive disease is suffered from abdominal pain by phlegm retention.1. " not Lu ": " main air is trembled with fear cough with dyspnea." 2. " property of medicine opinion ": " only gas is to dyspnea with rapid and short breath, and expectorant is drunk, broken stagnant blood, the disease of tumor wart between major event." 3. " detailed outline ": " dispersing wind and cold, therapeutic method to keep the adverse QI flowing downwards clearing away phlegm, row water removing blood stasis, parasite killing." 4. " Guangxi Chinese medicinal herbal ": " stimulates the menstrual flow, and cold expelling, eliminates the phlegm, diuresis." 5. " Jiangsu medical material will ": " diaphoresis, eliminates the phlegm.Cure cold headache, toothache, aphtha of the mouth and tongue." 6. " will planted by Tianmu Mountains of Zhejiang Province medicine ": " is emetic, eliminates the phlegm, diuresis.Control bronchitis and edema."
Strobilus Pini: [nature and flavor] " Shanxi Chinese herbal medicine ": " bitter, temperature." [function cures mainly] " Shanxi Chinese herbal medicine ": " antitussive, eliminate the phlegm, antiinflammatory, relievings asthma.Control chronic tracheitis, cough, breathes hard, expectorant of foaming at the mouth."
Fructus Lycii: [nature and flavor] are sweet is flat.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Rhizoma Polygonati: [nature and flavor] are sweet is flat.[return through] returns spleen, lung, kidney channel.[function cures mainly] boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Herba Pyrolae: [nature and flavor] sweetness and bitterness, temperature.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " warm in nature flat, acrid in the mouth." 2. " Shaanxi Chinese herbal medicine ": " is pained, flat." 3. " Shanxi Chinese herbal medicine ": " is sweet, temperature." [return through] " Zhiwu Mingshi Tukao ": " enters liver, kidney two warp." expelling wind and removing dampness, promoting blood flow to regulate menstruation, controls weak cough, over-strained hemoptysis, rheumatic arthritis, metrorrhagia, leucorrhea, traumatic hemorrhage for [function cures mainly] tonify deficiency, kidney tonifying.
Partition in Fructus Juglandis: [nature and flavor] " book on Chinese herbal medicine is new again ": " bitter and puckery flavor, property is put down, nontoxic." [return through] " book on Chinese herbal medicine is new again ": " enters spleen, kidney two warp." [function cures mainly] reinforcing the kindey to control nocturnal emission.Control seminal emission lingering diarrhea, gonorrhea, hematuria, incontinence of urine, metrorrhagia, leukorrhagia, dysentery.
Radix Habenariae Delavayi: [nature and flavor] are sweet, bitter, temperature.[function cures mainly] tonifies Qi of the kidney.For lumbago due to renal deficiency, nephritis, hernia, function of nervous system's disease.
The Radix Astragali: [nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Et Caulis Acanthopanacis Senticosi: [nature and flavor] pungent, micro-hardship, temperature.[return through] returns spleen, kidney, heart channel.[function cures mainly] replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Herba Themedae japonicae fruit: [nature and flavor] sweet in the mouth; Property is put down.[function cures mainly] consolidating superficial resistance arresting sweating.Main night sweat.
Herba avenae fatuae: [nature and flavor] are sweet is flat.[function cures mainly] astringing to arrest bleeding, strengthening superficial resistance to stop perspiration.For spitting blood, metrorrhagia, leucorrhea, has blood in stool, spontaneous perspiration, night sweat.
Radix Rhodiolae: [nature and flavor] are sweet, puckery, cold.[function cures mainly] clearing away lung-heat to relieve cough, hemostasis, leukorrhagia stopping.For cough due to lung-heat, spitting of blood, leucorrhea; Traumatic injury is controlled in external, burn and scald.
Radix Ranunculi Ternati: [nature and flavor] sweet, acrid, warm.1. " Chinese crude drug handbook ": " taste is micro-sweet." 2. " Guangxi Chinese medicinal herbal ": " sour in the mouth is sweet, and property is put down, nontoxic." 3. " Henan Chinese herbal medicine handbook ": " acrid in the mouth, warm in nature." [return through] " Guangxi Chinese medicinal herbal ": " enters liver, lung two warp." [function cures mainly] controls scrofula, pulmonary tuberculosis, malaria.1. " Chinese crude drug handbook ": " control scrofula tuberculosis on neck." 2. " Henan Chinese herbal medicine handbook ": " subsides a swelling, preventing the attack (or recurrence) of malaria.Control scrofula, pulmonary tuberculosis."
Fructus Jujubae: [nature and flavor] are sweet, temperature.[return through] returns spleen, stomach warp.[function cures mainly] be (Fructus Jujubae) really: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.
Rhizoma Saururi: [nature and flavor] Gan Xin, cold.1. " the SHENGCAO property of medicine is standby to be wanted ": " taste is sweet, cold." 2. " book on Chinese herbal medicine asks former ": " Gan Xin, cold." 3. " classifying herbal ": " bitter in the mouth, hot in nature." [function cures mainly] diuretic dehumidifies, heat-clearing and toxic substances removing.Control beriberi swelling shank, stranguria with turbid discharge, leukorrhagia, carbuncle, scabies.1. " detailed outline ": " treat beriberi, pathogenic wind toxic swelling shank, smash wine clothes.Decoct again soup and wash tinea scabies." 2. " the SHENGCAO property of medicine is standby to be wanted ": " controls stranguria with turbid discharge, diuresis, heat clearing away poison.Pull out slough bone, apply with Chen Meitong." 3. " classifying herbal ": " controls married woman's leucorrhea with red and white discharge.Just, the chest stuffiness relieving dried meat, preventing the attack (or recurrence) of malaria, subsides a swelling " 4. " conventional glossary of Herbs and Drugs among the people ": " profit two." 5. " Chongqing medical herbs ": " QI invigorating, spleen invigorating, dehumidifying.Control leucorrhea, consumptive disease, cough, spit blood, edema due to deficiency.Also for traumatic injury, bubble medicinal liquor for rheumatism."
Herba menyanthis: [nature and flavor] sweet, bitter, cold.[function cures mainly] clearing away heat and promoting diuresis, stomach invigorating, calms the nerves.For gastritis, dyspepsia, cholecystitis, jaundice, hypertension, cardiopalmus, insomnia.
Medulla Junci: [nature and flavor] are sweet, light, are slightly cold.[return through] GUIXIN, lung, small intestine meridian.[function cures mainly] clearing away heart-fire, diuresis.For vexed insomnia, the puckery pain of oliguria, aphtha of the mouth and tongue.
Semen Ziziphi Spinosae: [nature and flavor] are sweet is flat.1. " herbal classic ": " sour in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. amplification on Canon of Materia Medica: " tepor." 4. principle of Correct Diet: " sour in the mouth is sweet, flat." [return through] enters the heart, spleen, liver, gallbladder meridian.1. " detailed outline ": " sufficient the moon of fainting, few sun." 2. " Thunder God concocts property of medicine solution ": " enters the heart, spleen, liver, gallbladder four warp." [function cures mainly] nourishing the liver, mind calming, calms the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.
Radix Polygalae: [nature and flavor] are bitter, pungent, warm.[return through] GUIXIN, kidney, lung meridian.[function cures mainly] to be calmed the nerves Fructus Alpiniae Oxyphyllae, is eliminated the phlegm, detumescence.For the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
The Radix Stemonae: [nature and flavor] sweetness and bitterness, tepor.1. " not Lu ": " tepor." 2. TAO Hong-Jing: " is bitter strong, also slightly poisonous like Radix Asparagi." 3. " property of medicine opinion ": " sweet in the mouth is nontoxic.4. " Japan hanako materia medica ": " bitter in the mouth is nontoxic." [return through] enters lung meridian.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter lung." 2. " book on Chinese herbal medicine is newly organized ": " enters lung meridian, also enters spleen, stomach." [function cures mainly] gentle lung qi, cough-relieving, parasite killing.
Radix Rauvolfiae: [nature and flavor] are bitter, cold.1. " figure will planted by Guangxi medicine ": " bitter in the mouth, cold in nature, slightly poisonous." 2. " Nanning City's medicine will ": " is bitter sweet, cool, nontoxic." 3. " Guizhou medical herbs ": " property is put down, and salty in the mouth is micro-pungent." liver-fire, falls in [function cures mainly] fresh breeze heat, detumescence poison.Cure cold heating, laryngopharynx swelling and pain, and hypertension complicated headache is dizzy, and acute filthy disease stomachache is vomited and diarrhoea, pruritus due to wind pathogen skin ulcer scabies.
The Rhizoma Anemarrhenae: [nature and flavor] are bitter, sweet, cold.[return through] returns lung, stomach, kidney channel.[function cures mainly] clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Herba Orchidis Latifoliae: [nature and flavor] are sweet, flat.[function cures mainly] heart tonifying, the kidney invigorating, promotes the production of body fluid, and quenches the thirst, strengthening the spleen and stomach.
The present invention preferably only has above raw medicinal material to obtain.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1
Proportioning: meet gas grass 10g, Semen juglandis cathayensis 13g, water Herba Asari 8g, Herba Turczaninowiae Fastigiatae 8g, Radix Polemonii Liniflori 10g, Radix Glycyrrhizae 15g, Herba Asari Forbesii 6g, Strobilus Pini 6g, Fructus Lycii 8g, Rhizoma Polygonati 5g, Herba Pyrolae 9g, Partition in Fructus Juglandis 4g, Radix Habenariae Delavayi 5g, Radix Astragali 10g, Radix Et Caulis Acanthopanacis Senticosi 5g, Herba Themedae japonicae fruit 7g, Herba avenae fatuae 5g, Radix Rhodiolae 3g, Radix Ranunculi Ternati 4g, Fructus Jujubae 6g, Rhizoma Saururi 10g, Herba menyanthis 3g, Medulla Junci 7g, Semen Ziziphi Spinosae 6g, Radix Polygalae 10g, Radix Stemonae 2g, Radix Rauvolfiae 1g, Rhizoma Anemarrhenae 5g and Herba Orchidis Latifoliae 6g.
Its preparation method is:
The first step, by Radix Glycyrrhizae, Medulla Junci and the careless crushed into powder a that sleeps;
All the other raw medicinal materials described are mixed in proportion by second step, add the water soaking 2 hours of 4 times amount, then decoct 2 times, and first time decocts 1 hour, filters out filtrate, and the water adding 2 times amount of medicinal residues carries out second time decoction 1 hour again, again filters out filtrate; Twice filtrate is merged, add determining alcohol be 85% ethanol to the concentration of medicinal liquid be 45%, leave standstill 4 hours, filter, filtrate concentrates, and dry also pulverizing obtains powder b, powder b is mixed with powder a and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 2 hours;
3rd step, the determining alcohol that the mixed-powder that second step sterilizing obtains is joined 3 times of quality is the ethanol of 65%, airtight placement 24h, evenly moistening, be placed in percolation vat, the determining alcohol again adding the mixed-powder 1 times of quality obtained relative to second step is place 24h after the ethanol of 75%, with the diafiltration of 4ml/min speed, collects percolate; Extrude the medicinal liquid of balance in percolation vat, merge with above-mentioned percolate, leave standstill, clarified supernatant, filter, be concentrated into the spray that crude drug concentration is 2g/ml.
Embodiment 2
Proportioning: meet gas grass 20g, Semen juglandis cathayensis 25g, water Herba Asari 12g, Herba Turczaninowiae Fastigiatae 15g, Radix Polemonii Liniflori 15g, Radix Glycyrrhizae 20g, Herba Asari Forbesii 10g, Strobilus Pini 12g, Fructus Lycii 13g, Rhizoma Polygonati 8g, Herba Pyrolae 15g, Partition in Fructus Juglandis 9g, Radix Habenariae Delavayi 8g, Radix Astragali 15g, Radix Et Caulis Acanthopanacis Senticosi 7g, Herba Themedae japonicae fruit 12g, Herba avenae fatuae 12g, Radix Rhodiolae 8g, Radix Ranunculi Ternati 8g, Fructus Jujubae 12g, Rhizoma Saururi 15g, Herba menyanthis 7g, Medulla Junci 12g, Semen Ziziphi Spinosae 10g, Radix Polygalae 14g, Radix Stemonae 4g, Radix Rauvolfiae 3g, Rhizoma Anemarrhenae 9g and Herba Orchidis Latifoliae 10g.
Its preparation method is:
The first step, by Radix Glycyrrhizae, Medulla Junci and the careless crushed into powder a that sleeps;
All the other raw medicinal materials described are mixed in proportion by second step, add the water soaking 2 hours of 4 times amount, then decoct 2 times, and first time decocts 1 hour, filters out filtrate, and the water adding 2 times amount of medicinal residues carries out second time decoction 1 hour again, again filters out filtrate; Twice filtrate is merged, add determining alcohol be 90% ethanol to the concentration of medicinal liquid be 50%, leave standstill 5 hours, filter, filtrate concentrates, and dry also pulverizing obtains powder b, powder b is mixed with powder a and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 2 hours;
3rd step, the determining alcohol that the mixed-powder that second step sterilizing obtains is joined 3 times of quality is the ethanol of 70%, airtight placement 48h, evenly moistening, be placed in percolation vat, the determining alcohol again adding the mixed-powder 1 times of quality obtained relative to second step is place 48h after the ethanol of 75%, with the diafiltration of 5ml/min speed, collects percolate; Extrude the medicinal liquid of balance in percolation vat, merge with above-mentioned percolate, leave standstill, clarified supernatant, filter, be concentrated into the spray that crude drug concentration is 2g/ml.
Embodiment 3
Proportioning: meet gas grass 15g, Semen juglandis cathayensis 18g, water Herba Asari 10g, Herba Turczaninowiae Fastigiatae 12g, Radix Polemonii Liniflori 12g, Radix Glycyrrhizae 17g, Herba Asari Forbesii 7g, Strobilus Pini 10g, Fructus Lycii 10g, Rhizoma Polygonati 7g, Herba Pyrolae 13g, Partition in Fructus Juglandis 5g, Radix Habenariae Delavayi 6g, Radix Astragali 13g, Radix Et Caulis Acanthopanacis Senticosi 6g, Herba Themedae japonicae fruit 10g, Herba avenae fatuae 8g, Radix Rhodiolae 6g, Radix Ranunculi Ternati 6g, Fructus Jujubae 8g, Rhizoma Saururi 12g, Herba menyanthis 6g, Medulla Junci 8g, Semen Ziziphi Spinosae 8g, Radix Polygalae 12g, Radix Stemonae 3g, Radix Rauvolfiae 2g, Rhizoma Anemarrhenae 7g and Herba Orchidis Latifoliae 8g.
Its preparation method is:
The first step, by Radix Glycyrrhizae, Medulla Junci and the careless crushed into powder a that sleeps;
All the other raw medicinal materials described are mixed in proportion by second step, add the water soaking 1 hour of 3 times amount, then decoct 2 times, and first time decocts 2 hours, filters out filtrate, and the water adding 3 times amount of medicinal residues carries out second time decoction 1 hour again, again filters out filtrate; Twice filtrate is merged, add determining alcohol be 90% ethanol to the concentration of medicinal liquid be 50%, leave standstill 3 hours, filter, filtrate concentrates, and dry also pulverizing obtains powder b, powder b is mixed with powder a and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 hour;
3rd step, the determining alcohol that the mixed-powder that second step sterilizing obtains is joined 2 times of quality is the ethanol of 70%, airtight placement 24h, evenly moistening, be placed in percolation vat, the determining alcohol again adding the mixed-powder 1 times of quality obtained relative to second step is place 48h after the ethanol of 80%, with the diafiltration of 5ml/min speed, collects percolate; Extrude the medicinal liquid of balance in percolation vat, merge with above-mentioned percolate, leave standstill, clarified supernatant, filter, be concentrated into the spray that crude drug concentration is 2g/ml.
Embodiment 4
Proportioning: meet gas grass 12g, Semen juglandis cathayensis 18g, water Herba Asari 9g, Herba Turczaninowiae Fastigiatae 12g, Radix Polemonii Liniflori 12g, Radix Glycyrrhizae 16g, Herba Asari Forbesii 8g, Strobilus Pini 10g, Fructus Lycii 10g, Rhizoma Polygonati 6g, Herba Pyrolae 12g, Partition in Fructus Juglandis 5g, Radix Habenariae Delavayi 7g, Radix Astragali 13g, Radix Et Caulis Acanthopanacis Senticosi 6g, Herba Themedae japonicae fruit 9g, Herba avenae fatuae 9g, Radix Rhodiolae 5g, Radix Ranunculi Ternati 7g, Fructus Jujubae 8g, Rhizoma Saururi 13g, Herba menyanthis 6g, Medulla Junci 9g, Semen Ziziphi Spinosae 8g, Radix Polygalae 12g, Radix Stemonae 3g, Radix Rauvolfiae 2g, Rhizoma Anemarrhenae 7g and Herba Orchidis Latifoliae 8g.
Its preparation method comprises the following steps:
The first step, will connect the mixing of gas grass, Semen juglandis cathayensis and water Herba Asari, add relative to mixture 4 times amount determining alcohol be 60% alcohol reflux 2 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, is concentrated into the mastic a that 70 DEG C of relative densities are 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 times of water gagings, boils 2 hours, filters, is concentrated into the mastic b that 70 DEG C of relative densities are 1.28;
3rd step, mixes mastic a and mastic b, 60 DEG C of reduced vacuum dryings, and get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 35 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001; The time of described heat treated is 30 minutes, and temperature is 100 DEG C ~ 110;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain oral solutions.
The toxicity test of medicine
1. acute toxicity test: with the spray of the embodiment of the present invention 1 for object, gives white mouse large enteral dispensing, observes 7 for 150 times of clinical consumption per day.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse vagina and damaged skin, there are no irritative response and other untoward reaction.Toxicity test proves, the present invention does not have toxic action and untoward reaction, and clinical practice is safe and reliable.
2. long term toxicity test: the spray of the embodiment of the present invention 3 presses 10,20 and 30g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical trial
Case selection: during selecting in January ,-2014 in January, 2013, affected children ranges totally 250 examples of the Lungs of Children kidney deficiency asthma of certain children's hospital's diagnosis and treatment.Wherein, man 125 example, female 125 example, 5 years old-8 years old age 95 example, 8 years old-10 years old 85 example, 11-15 year 70example.Be divided into five groups at random, often organize 50 people, embodiment 1 group, embodiment 2 groups, embodiment 3 groups, embodiment 4 groups and matched group.Five groups of infants comparing difference not statistically significant in age, sex, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.
Diagnostic criteria:
1) with dyspnea with shortness of breath, dyspnea, even opening mouth and lifting shoulder due to dyspnea, flaring of nares, can not put down sleeping, and lip cyanosis is feature;
2) there is chronic cough, bronchial wheezing, pulmonary tuberculosis, the history of disease such as cardiopalmus, whenever diseases caused by exogenous pathogenic factor and tired and bring out more;
3) in barrel chest, percussion chest is hyperresonant note, and border of cardiac dullness reduces or disappears, and liver dullness circle moves down.Pulmonary respiration sound lowers, audible and dry, moist rale or wheezing sound.Or hepatomegaly, edema of lower limbs, distension of jugular vein;
4) concurrent infection person, total white blood cells and neutrophilic granulocyte can increase.To have a blood test if desired potassium, sodium, CO2 combining power, CO2 CP and x-ray chest radiography, electrocardiogram, the heart, lung function tests, blood gas analysis etc.;
5) deficiency of both the lung and kidney: with the passing of time, severe palpitation, dynamic then breath with cough, shortness of breath, uncomfortable in chestly can not put down sleeping as stopped up, abundant expectoration and gluing, or dysphoria and insomnia, cyanosis of the lips and nails in dyspnea with rapid and short breath.Body of the tongue is purple or red tongue tongue is few, faint pulse disease or knot, generation.
Therapeutic Method:
Embodiment 1 group: this group uses the spray of embodiments of the invention 1 to treat.Squeeze spraying liquid to oral cavity appropriate, 3 times on the one, February is a course for the treatment of, treats 3 courses for the treatment of at every turn.
Embodiment 2 groups: this group uses the spray of embodiments of the invention 2 to treat.Squeeze spraying liquid to oral cavity appropriate, 3 times on the one, February is a course for the treatment of, treats 3 courses for the treatment of at every turn.
Embodiment 3 groups: this group uses the spray of embodiments of the invention 3 to treat.Squeeze spraying liquid to oral cavity appropriate, 3 times on the one, February is a course for the treatment of, treats 3 courses for the treatment of at every turn.
Embodiment 4 groups: this group uses the oral solutions of embodiments of the invention 4 to treat.Each oral 5ml, 3 times on the one, February is a course for the treatment of, treats 3 courses for the treatment of.
Matched group: this group uses children's's compound hydrochloric acid tulobuterol sheet to treat.Child one time 1,3 times on the one, panting to change every day after alleviating takes 1 ~ 2 time.February is a course for the treatment of, treats 3 courses for the treatment of.
Efficacy evaluation
Clinical cure: asthma and other transference cure, lab testing is clearly better.
Take a turn for the better: asthma and other symptom take a turn for the better, and lab testing is improved.
Do not heal: primary symptom is not improved or deterioration person.
Therapeutic outcome
Table 1 is the treatment situation contrast of each group
Group Clinical cure Take a turn for the better Do not heal
Embodiment 1 group 49(98%) 1(2%) 0(0%)
Embodiment 2 groups 50(100%) 0(0%) 0(0%)
Embodiment 3 groups 50(100%) 0(0%) 0(0%)
Embodiment 4 groups 48(96%) 1(2%) 1(2%)
Matched group 20(40%) 10(20%) 20(40%)
As can be seen from Table 1, the treatment situation of four embodiment groups is better than the therapeutic effect of matched group, it can thus be appreciated that medicine of the present invention, in treatment Lungs of Children kidney deficiency asthma, therapeutic effect is good, determined curative effect.
Table 2 is the treatment time contrast of the healing of each group
Group Clinical cure number First course for the treatment of Second course for the treatment of 3rd course for the treatment of
Embodiment 1 group 49 7(14.3%) 20(40.8%) 22(44.9%)
Embodiment 2 groups 50 8(16%) 21(42%) 21(42%)
Embodiment 3 groups 50 7(14%) 22(44%) 21(42%)
Embodiment 4 groups 48 6(12.5%) 20(41.7%) 22(45.8%)
Matched group 20 2(10%) 5(25%) 13(65%)
As can be seen from Table 2, the healing number that first course for the treatment of of four embodiment groups cures is higher than matched group, it can thus be appreciated that medicine of the present invention, in treatment Lungs of Children kidney deficiency asthma, treatment speed is fast, instant effect.
Table 3 is recurrence and side effect contrast (toxic and side effects rate=side effect number/total number of persons, relapse rate=recurrence number/clinical cure number) of each group
Group Toxic and side effects incidence rate Relapse rate
Embodiment 1 group 0(0%) 0(0%)
Embodiment 2 groups 0(0%) 0(0%)
Embodiment 3 groups 0(0%) 0(0%)
Embodiment 4 groups 0(0%) 0(0%)
Matched group 5(10%) 1(5%)
As can be seen from Table 3, the toxic and side effects of 4 embodiment groups and recurrence number are all better than matched group.It can thus be appreciated that Drug therapy Lungs of Children kidney deficiency asthma of the present invention, does not have toxic and side effects, does not recur.
Model case: children's hospital of Shandong Province accepts the boy of diagnosis and treatment, 9 years old, suffers from deficiency of both the lung and kidney type asthma 1 year half.The spray of embodiments of the invention 1 is used to treat.Squeeze spraying liquid to oral cavity appropriate, 3 times on the one, February is a course for the treatment of, treats 3 courses for the treatment of at every turn.In therapeutic process, do not occur other untoward reaction, treatment carries out 3 courses for the treatment of, clinical cure.Later stage follows up half a year, does not recur.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (4)

1. treat the spray of Lungs of Children kidney deficiency asthma for one kind, it is characterized in that, obtained by the raw medicinal material of following mass fraction: connect gas grass 10-20 weight portion, Semen juglandis cathayensis 13-25 weight portion, water Herba Asari 8-12 weight portion, Herba Turczaninowiae Fastigiatae 8-15 weight portion, Radix Polemonii Liniflori 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, Herba Asari Forbesii 6-10 weight portion, Strobilus Pini 6-12 weight portion, Fructus Lycii 8-13 weight portion, Rhizoma Polygonati 5-8 weight portion, Herba Pyrolae 9-15 weight portion, Partition in Fructus Juglandis 4-9 weight portion, Radix Habenariae Delavayi 5-8 weight portion, Radix Astragali 10-15 weight portion, Radix Et Caulis Acanthopanacis Senticosi 5-7 weight portion, Herba Themedae japonicae fruit 7-12 weight portion, Herba avenae fatuae 5-12 weight portion, Radix Rhodiolae 3-8 weight portion, Radix Ranunculi Ternati 4-8 weight portion, Fructus Jujubae 6-12 weight portion, Rhizoma Saururi 10-15 weight portion, Herba menyanthis 3-7 weight portion, Medulla Junci 7-12 weight portion, Semen Ziziphi Spinosae 6-10 weight portion, Radix Polygalae 10-14 weight portion, Radix Stemonae 2-4 weight portion, Radix Rauvolfiae 1-3 weight portion, Rhizoma Anemarrhenae 5-9 weight portion and Herba Orchidis Latifoliae 6-10 weight portion.
2. the spray for the treatment of Lungs of Children kidney deficiency asthma according to claim 1, it is characterized in that, the raw medicinal material of following mass fraction is had to obtain: to connect gas grass 15 weight portions, Semen juglandis cathayensis 18 weight portion, water Herba Asari 10 weight portion, Herba Turczaninowiae Fastigiatae 12 weight portion, Radix Polemonii Liniflori 12 weight portion, Radix Glycyrrhizae 17 weight portion, Herba Asari Forbesii 7 weight portion, Strobilus Pini 10 weight portion, Fructus Lycii 10 weight portion, Rhizoma Polygonati 7 weight portion, Herba Pyrolae 13 weight portion, Partition in Fructus Juglandis 5 weight portion, Radix Habenariae Delavayi 6 weight portion, the Radix Astragali 13 weight portion, Radix Et Caulis Acanthopanacis Senticosi 6 weight portion, Herba Themedae japonicae fruit 10 weight portions, Herba avenae fatuae 8 weight portion, Radix Rhodiolae 6 weight portion, Radix Ranunculi Ternati 6 weight portion, Fructus Jujubae 8 weight portion, Rhizoma Saururi 12 weight portion, Herba menyanthis 6 weight portion, Medulla Junci 8 weight portion, Semen Ziziphi Spinosae 8 weight portion, Radix Polygalae 12 weight portion, the Radix Stemonae 3 weight portion, Radix Rauvolfiae 2 weight portion, the Rhizoma Anemarrhenae 7 weight portion and Herba Orchidis Latifoliae 8 weight portion.
3. the spray for the treatment of Lungs of Children kidney deficiency asthma according to claim 1 and 2, it is characterized in that, its preparation method comprises the following steps:
The first step, by Radix Glycyrrhizae, Medulla Junci and the careless crushed into powder a that sleeps;
All the other raw medicinal materials described are mixed in proportion by second step, add the water soaking 1-2 hour of 3 ~ 5 times amount, then decoct 2 times, first time decocts 1 ~ 2 hour, filters out filtrate, the water adding the 1-3 times amount of medicinal residues carries out second time again and decocts 0.5-1 hour, again filters out filtrate; Twice filtrate is merged, add determining alcohol be 80% ~ 90% ethanol to the concentration of medicinal liquid be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and dry also pulverizing obtains powder b, is mixed by powder b obtain mixed-powder with powder a, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;
3rd step, the determining alcohol that the mixed-powder that second step sterilizing obtains is joined 2 ~ 3 times of quality is the ethanol of 60% ~ 70%, airtight placement 24h ~ 48h, evenly moistening, be placed in percolation vat, the determining alcohol again adding mixed-powder 1 ~ 2 times of quality obtained relative to second step is place 24h ~ 48h after the ethanol of 75% ~ 80%, with the diafiltration of 3 ~ 5ml/min speed, collects percolate; Extrude the medicinal liquid of balance in percolation vat, merge with above-mentioned percolate, leave standstill, clarified supernatant, filter, be concentrated into the spray that crude drug concentration is 2g/ml.
4. a preparation method for the spray of the treatment Lungs of Children kidney deficiency asthma described in any one of claims 1 to 3, is characterized in that, comprise the following steps:
The first step, by Radix Glycyrrhizae, Medulla Junci and the careless crushed into powder a that sleeps;
All the other raw medicinal materials described are mixed in proportion by second step, add the water soaking 1-2 hour of 3 ~ 5 times amount, then decoct 2 times, first time decocts 1 ~ 2 hour, filters out filtrate, the water adding the 1-3 times amount of medicinal residues carries out second time again and decocts 0.5-1 hour, again filters out filtrate; Twice filtrate is merged, add determining alcohol be 80% ~ 90% ethanol to the concentration of medicinal liquid be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and dry also pulverizing obtains powder b, is mixed by powder b obtain mixed-powder with powder a, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;
3rd step, the determining alcohol that the mixed-powder that second step sterilizing obtains is joined 2 ~ 3 times of quality is the ethanol of 60% ~ 70%, airtight placement 24h ~ 48h, evenly moistening, be placed in percolation vat, the determining alcohol again adding mixed-powder 1 ~ 2 times of quality obtained relative to second step is place 24h ~ 48h after the ethanol of 75% ~ 80%, with the diafiltration of 3 ~ 5ml/min speed, collects percolate; Extrude the medicinal liquid of balance in percolation vat, merge with above-mentioned percolate, leave standstill, clarified supernatant, filter, be concentrated into the spray that crude drug concentration is 2g/ml.
CN201510878682.0A 2015-12-04 2015-12-04 Spray for treating infant lung-kidney-deficiency type asthma and preparing method thereof Withdrawn CN105267815A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105535689A (en) * 2016-01-29 2016-05-04 赵学霞 Medicine composition for treating child wind-cold lung tightening type asthma and preparation method of medicine composition

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103784534A (en) * 2012-10-29 2014-05-14 刘黎明 Traditional Chinese medicine aerosol used for preventing and treating children heat asthma
CN104984311A (en) * 2015-08-10 2015-10-21 青岛蓝盛洋医药生物科技有限责任公司 Traditional Chinese medicine composite for treating child asthma and preparation method thereof
CN104998014A (en) * 2015-08-25 2015-10-28 崔新明 Purpose of traditional Chinese medicine composition for preparing medicine for treating infantile asthma

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103784534A (en) * 2012-10-29 2014-05-14 刘黎明 Traditional Chinese medicine aerosol used for preventing and treating children heat asthma
CN104984311A (en) * 2015-08-10 2015-10-21 青岛蓝盛洋医药生物科技有限责任公司 Traditional Chinese medicine composite for treating child asthma and preparation method thereof
CN104998014A (en) * 2015-08-25 2015-10-28 崔新明 Purpose of traditional Chinese medicine composition for preparing medicine for treating infantile asthma

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105535689A (en) * 2016-01-29 2016-05-04 赵学霞 Medicine composition for treating child wind-cold lung tightening type asthma and preparation method of medicine composition

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Application publication date: 20160127