CN105535495A - Chinese medicinal composition for treating esophageal cancer by reinforcing vital essence and strengthening primordial qi and preparation method - Google Patents

Chinese medicinal composition for treating esophageal cancer by reinforcing vital essence and strengthening primordial qi and preparation method Download PDF

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CN105535495A
CN105535495A CN201610030221.2A CN201610030221A CN105535495A CN 105535495 A CN105535495 A CN 105535495A CN 201610030221 A CN201610030221 A CN 201610030221A CN 105535495 A CN105535495 A CN 105535495A
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radix
chinese medicine
medicine composition
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CN105535495B (en
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杨雷
徐国昌
刘暖
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Nanyang Institute of Technology
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    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention in particular relates to a Chinese medicinal composition for treating esophageal cancer by reinforcing vital essence and strengthening primordial qi. The Chinese medicinal composition comprises the following active pharmaceutical ingredients in parts by weight: 10 to 30 parts of placenta hominis, 10 to 30 parts of pilose antler, 10 to 30 parts of red ginseng, 10 to 20 parts of trogopterus dung, 10 to 35 parts of panax notoginseng, 10 to 20 parts of amber, 10 to 35 parts of astragalus, 10 to 45 parts of seaweed, 10 to 20 parts of semen momordicae, 10 to 35 parts of vinegar turtle shell, 10 to 25 parts of raw pinellia, 5 to 15 parts of manyleaf paris rhizome, 10 to 35 parts of oyster, 10 to 20 parts of scorpion, 10 to 20 parts of centipede, 10 to 15 parts of dioscorea bulbifera L, 10 to 20 parts of edible tulip, 10 to 20 parts of subprostrate sophora, 5 to 15 parts of realgar and 10 to 45 parts of fresh licorice. The Chinese medicinal composition disclosed by the invention adopts the method of strengthening the body resistance and eliminating evil, and is suitable for patients with greatly undermined vitality, body asthenia and fatigue and weakened body resistance so as not to resist the evil, and declined quality of life after operation or radiotherapy and chemotherapy of the esophageal cancer.

Description

A kind of Chinese medicine composition of the element culturing fixed folder treatment esophageal carcinoma and preparation method
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to the Chinese medicine composition of a kind of element culturing fixed folder treatment esophageal carcinoma.
Background technology
The esophageal carcinoma is one of modal malignant tumor of China, accounts for 21.80% of national malignant tumor, is only second to gastric cancer, account for second.The whole world about has 300,000 people to die from the esophageal carcinoma every year.50 ~ 60 years old number of the infected accounts for total morbidity people's 66.14% according to statistics.China is one of Esophageal Cancer area in the world, and every annual is died of illness about 150,000 people.Male's sickness rate is higher than women 4 times.Its M & M increases with the age and increases progressively.Morbidity in geographical distribution by the southeast to northwest to progressively improving, the sickness rate of district occurred frequently, mortality rate differ with Di Fa district and reach 100 times.The typical symptom of the esophageal carcinoma is Progressive symmetric erythrokeratodermia acataposis, before this food of difficult dry pharynx, is semiliquid diet then, and last water and saliva can not be swallowed.Often telling mucoid expectorant, is the saliva of hypopharynx and the secretions of esophagus.Patient becomes thin gradually, dewater, unable.Lasting chest pain or backache are expressed as symptom in late period, and cancer has been invaded esophagus and organized outward.The Crowds Distribute of the esophageal carcinoma and age, sex, occupation, race, region, living environment, dietary life habits, genetic predisposition etc. have certain relation.Through the disease that the existing survey data display esophageal carcinoma may be caused by many factors.The cause of disease proposed is as follows: 1. chemical cause of disease nitrosamine.This compounds and precursor distribution very wide, can in vivo, outer formation, carcinogenecity is strong.In the saliva of the meals in district occurred frequently, drinking-water, sauerkraut, even patient, survey content of nitrite all far beyond Di Fa district be height.2. biological agent fungus.In the grain of some district occurred frequently, in the upper digestive tract of Patients With Carcinoma of Esophagus or in the esophageal carcinoma specimen of excision, all can isolate multiple fungus, wherein some fungus has carcinogenesis.Some fungus can impel the formation of nitrosamine and precursor thereof, more promotes the generation of cancerous protuberance.3. lack the content in grain, vegetable, drinking-water such as some trace element molybdenum, ferrum, zinc, fluorine, selenium on the low side.4. be deficient in vitamin A, vitamin B2, vitamin C and animal proteinum, fresh vegetables, fruit Deficiency of Intake, is a common feature of Esophageal Cancer in High Risk Areas.5. the factors such as cigarette, wine, heat food, hot drink, oral cavity be unclean are drunk ardent spirits for a long time, are had a liking for smoking, and food is really up to the mark, overheated, it is too fast to take food, and cause that chronic stimulation, inflammation, wound or oral cavity are unclean, dental caries etc. all may be relevant with the generation of the esophageal carcinoma.6. esophageal cancer genetic predisposing factor.
Motherland's medical science thinks that primary disease belongs to the dysphagic scope of Chinese medicine.Dysphagic is because esophagus is dry and astringent or esophagostenosis causes swallowing food and chokes with sobs and have some setbacks, inappetence, or food and the illness of appearing again.Choking is dysphagia, chokes with sobs and have some setbacks when referring to swallow; Belch as lattice are refused, refer to inappetence.Can occur separately though choke, and be often the prodroma of diaphragm, thus clinical often with dysphagic and claim.The name of diaphragm, head sees "Nei Jing"." Plain Questions negative and positive another matter " cloud " three constipation caused by accumulation of heats, the diaphragm of meaning." " Plain Questions is logical comments deficiency and excess opinion " cloud: " diaphragm plug closes absolutely, obstructed up and down, then disease due to intense worry is also." these discussions inquire into dysphagic etiology and pathogenesis to descendant, recipe is prescribed after the establishment of the principle for the treatment of edifies very large.Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases " is divided into gas by dysphagic, melancholy, food, labor, and think five and choke and melancholy, anger, gas, cold, hot five diaphragms, point out that Nervous and Mental Factors is very large on the impact of primary disease.Song Yanyong and " Prescriptions for Succouring the Sick. five five diaphragms opinions of choking are controlled " think: " yang-energy is first tied, and, disorder of YIN and YANG, internal organs are sick, tie in chest and diaphragm, then become diaphragm, and gas stays in pharynx, then become five to choke after cloudy gas disorderly." and propose the Therapeutic Principle of " adjust along negative and positive, eliminating phlegm and keeping the adverse QI downwards ".Unit's ZHU Dan-xi " arteries and veins because of card control dysphagic " cloud: " probably because of blood tool consumption, gastral cavilty is also withered, and saying of name is choked under upper nearly pharynx.Its withered under, with stomach be nearly name say diaphragm." method for the treatment of of proposition " profit supports Tianjin blood, pathogenic fire reducing eliminating stagnation ", then heavy is logical with profit.Bright Zhang Jingyue is comparatively comprehensively discussed dysphagic having carried out, and point out that dysphagic is two different diseases from regurgitation, think that The spleen has the function to transport and transform nutrients, kidney is for changing root of life, transformation failure of spleen, and essence and blood dries up for pathogenesis place, thus proposes the principle for the treatment of of warming the spleen nourishing kidney.Clear YE Tian shi proposes the etiology and pathogenesis that " the narrow mountain pass of gastral cavity pipe " is primary disease in " Linzheng Zhinan Yi dysphagia and regurgitation ", and this viewpoint is still significant to present clinical treatment.Thought Zhang Xichun in modern age " Records of Tradition Chinese and Western Medicine in Combination " dysphagic " no matter what has congestion because, its cardia is long-pending person ten seven or eight ", and emphasized blood circulation promoting and blood stasis dispelling importance in the treatment, and point out that prognosis is relevant with " the root base of a fruit of congestion is clean, is have to send out it again ".
The western medical treatment esophageal carcinoma, follow its consistent since the theory of dividing and rule, " take stopgap measures ", ignores the globality of people.The esophageal carcinoma belongs to categories such as " dysphagic " from traditional Chinese medical science angle, and its main pathogenesis is gas, expectorant, stasis of blood knot, intercepts in esophagus, gastral cavilty and causing.Sick position, at esophagus, belongs to stomach and led, closely related with liver spleen kidney.Pathologic feature mainly contains deficiency and excess two aspect, is the card of deficiency in origin and excess in superficiality.Deficiency in origin and deficiency of spleen and stomach, body fluid is withered, can not moisten foster relevant; Mark is real be the stagnation of QI, blood stasis, and expectorant is solidifying to be hindered in esophagus stomach function regulating, and causing chokes with sobs has some setbacks, and under lattice plug difficulty or food and appearing again, and to send out be dysphagic.At the primary disease initial stage, hand over hinder in esophagus stomach function regulating based on mental disorder, the state of an illness is comparatively light, mostly empirical, and continue the interior knot of then blood stasis, mental disorder stasis of blood three knot, and then fire-transformation impairment of YIN, or expectorant stasis of blood heat-dissipating, and impairment of YIN consumption liquid, then the state of an illness is weighed by light turning.Sick to late period, cloudy Tianjin is day by day withered, and stomach abdomen loses it and moistens foster, or deficiency of YIN affecting YANG, and spleen kidney yang weakness of QI loses, and can not steam Tianjin Hua Jin, and fortune Tianjin, mental disorder stasis benefit very, develops into the time of simulataneous insufficiency and excessive.Clinical manifestation is uncomfortable after breastbone, and burn feeling or pain, food is by there being Progressive symmetric erythrokeratodermia, and persistence dysphagia, swallows and block, and eats and namely tells, progressive emaciation.The common mental disorder that mainly contains hands over resistance card, syndrome of deficiency of fluid and accumulated heat, knot card in blood stasis, deficiency of QI and declination of YANG card Four types.Operation generally taked by Western medicine, radiotherapy, the methods such as chemotherapy, but cures the symptoms, not the disease, and attacks heresy and just hindering again, fundamentally can not improve life in patients, extends the survival of patients time.Patent of the present invention explains from the angle of Chinese medicine and the treatment esophageal carcinoma is the properest.The medicated wine vital base and primordial QI consolidating treatment esophageal carcinoma that this patent system is standby, it is evident in efficacy, and five year survival rate can reach more than 70%, and clinical effective rate reaches more than 80%; And to the treatment of other digestive system tumor as gastric cancer, colon cancer etc. also have good effect.
Summary of the invention
The object of the present invention is to provide a kind of vital base and primordial QI consolidating to treat the Chinese medicine composition of the esophageal carcinoma, there is vital base and primordial QI consolidating, hold up beneficial healthy energy, anticancer function of getting rid of evils, be used for the treatment of the treatment of the esophageal carcinoma and other digestive system tumors.
Another object of the present invention is to provide a kind of Chinese medicine vital base and primordial QI consolidating to treat the Chinese medicine composition preparation method of the esophageal carcinoma.
For achieving the above object, the present invention adopts following technical scheme:
The Chinese medicine composition of this element culturing fixed folder treatment esophageal carcinoma, it is characterized in that, this Chinese medicine composition comprises the crude drug of following parts by weight: Placenta Hominis 10-30 part, Cornu Cervi Pantotrichum 10-30 part, Radix Ginseng Rubra 10-30 part, Oletum Trogopterori 10-20 part, Radix Notoginseng 10-35 part, succinum 10-20 part, Radix Astragali 10-35, Sargassum 10-45 part, Semen Momordicae 10-20 part, Carapax Trionycis (processed with vinegar) 10-35 part, Rhizoma Pinelliae 10-25 part, Rhizoma Paridis 5-15 part, Concha Ostreae 10-35 part, Scorpio 10-20 part, Scolopendra 10-20 part, Rhizoma Dioscoreae Bulbiferae 10-15 part, Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Radix Sophorae Tonkinensis 10-20 part, Realgar 5-15 part, Radix Glycyrrhizae 10-45 part.
Described Chinese medicine composition comprises the crude drug of following parts by weight: Placenta Hominis 10-25 part, Cornu Cervi Pantotrichum 10-25 part, Radix Ginseng Rubra 10-25 part, Oletum Trogopterori 10-15 part, Radix Notoginseng 15-30 part, succinum 15-20 part, Radix Astragali 15-30 part, Sargassum 15-40 part, Semen Momordicae 10-15 part, Carapax Trionycis (processed with vinegar) 15-30 part, Rhizoma Pinelliae 10-20 part, Rhizoma Paridis 10-15 part, Concha Ostreae 10-30 part, Scorpio 10-15 part, Scolopendra 10-15 part, Rhizoma Dioscoreae Bulbiferae 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 10-15 part, Radix Sophorae Tonkinensis 10-15 part, Realgar 8-10 part, Radix Glycyrrhizae 15-30 part.
Described Chinese medicine composition comprises the crude drug of following parts by weight: Placenta Hominis 15 parts, 15 parts, Cornu Cervi Pantotrichum, Radix Ginseng Rubra 20 parts, Oletum Trogopterori 12 parts, Radix Notoginseng 20 parts, succinum 15 parts, the Radix Astragali 30 parts, Sargassum 30 parts, Semen Momordicae 12 parts, Carapax Trionycis (processed with vinegar) 20 parts, Rhizoma Pinelliae 15 parts, Rhizoma Paridis 12 parts, Concha Ostreae 20 parts, Scorpio 12 parts, Scolopendra 12 parts, Rhizoma Dioscoreae Bulbiferae 15 parts, Pseudobulbus Cremastrae Seu Pleiones 12 parts, Radix Sophorae Tonkinensis 10 parts, Realgar 10 parts, Radix Glycyrrhizae 20 parts.
The Chinese medicine composition preparation method of this element culturing fixed folder treatment esophageal carcinoma, is characterized in that, comprise the following steps:
(1) get crude drug to add in the ethanol of 5-6 times amount and soak 1.5-2h, heating extraction 2-3 time, each 1.5-2h, merge extractive liquid, then 100-140 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, and ultrafiltrate is evaporated to the extractum of 1.15-1.20g/mL when relative density is 60-70 DEG C, stand for standby use is component A;
(2) medicinal residues of the crude drug crossed by step (1) ethanol extraction add 5-10 times amount distilled water, heating and refluxing extraction 2-3 time, at every turn l.5-2h, merge extractive liquid, leaving standstill, is B component;
(3) by the merging of component A and B component, sucking filtration, then being evaporated to liquor strength is 1.0-1.1g/mL, then through macroporous adsorptive resins absorption, with the distilled water eluting of 8-12 times of resin column volume, again with the dehydrated alcohol eluting of 5-6 times of resin column volume, collect ethanol elution, remove solvent, obtain medicated powder, incapsulate, every 0.5-1.0g.
The Chinese medicine composition preparation method of this element culturing fixed folder treatment esophageal carcinoma, is characterized in that, comprise the following steps:
(1) by various crude drug roguing, dry, be ground into granule, soak 1.5-2h: soaked raw material is put in multi-function extractor and decocts with water 2-3 time, the water of first time totalling medical material 5-10 times amount, decoct 1.5-2h, get decocting liquid, filter, second time adds the water of total amount 4-6 times amount, decoct l-1.2h, get twice decocting liquid mixing, filter;
(2) be the concentrated solution of 1.10-1.20 by the filtrate reduced in volume of filtration to relative density during 70-80 DEG C, set to 0-5 DEG C of deepfreeze 20-24h;
(3) step (2) cold preservation liquid is added kieselguhr, filter, filtrate reduced in volume, is dried to powder, incapsulates, every 0.5-1.0g.
The instructions of taking of the endo-medicine of the vital base and primordial QI consolidating treatment esophageal carcinoma of the present invention: every day 2-3 time, each 1-3 grain, every 0.5-1.0g, 30 days courses for the treatment of.
The pharmacological action of the various crude drug of Chinese medicine composition of the present invention:
Placenta Hominis, property sweet-salty, temperature, returns lung, kidney, Liver Channel, the kidney invigorating and essence nourishing, nourishing blood and invigorating qi.For impotence and seminal emission, the soreness of waist, dizzy, tinnitus, insufficiency of vital energy and blood, lung is suffered from a deficiency of the kidney and is breathed heavily all diseases.Supplement to the Herbal: " control blood deficiency weakness and emaciation, married woman's asthenia, face dried bark is black, all diseases gradually thin worried person in abdomen." Bencao Jingshu ": " plancenta hominis is the medicine mending deficiency of both YIN and YANG, has the merit returning this reduction.Modern pharmacology research shows: containing Multiple Antibodies in placental globulin goods, long-term for passive immunity clinically.Also containing interferon in Human plactnta, have and suppress multiple virus to the effect of people's cell, and containing the macroglobulin of influenza virus can be suppressed, claim β-inhibitive factor.The antibody of Placenta Hominis also containing some infectious disease anti-, in addition, containing multiple enzyme system in Placenta Hominis, enhancing body resistance, tool immunity and anti-allergic effects.
Cornu Cervi Pantotrichum, property sweet-salty, temperature.Return kidney, Liver Channel, kidney-replenishing, benefiting essence-blood, bone and muscle strengthening, adjust punching to appoint, holder sore, for kidney yang deficiency, asthenia of essence and blood is demonstrate,proved, weak bone of suffering from a deficiency of the kidney, weakness of the waist and knees or children's's five kinds of growth retardation, women's cold and deficiency of CHONG and REN meridians, bleeding not during menses, and skin infection is burst for a long time and do not held back, and carbuncle of yin nature skin ulcer is swollen can not cave in.Shennong's Herbal: " lead stagnant blood, cold and heat infantile convulsion, the strong will of QI invigorating, the population is not old." Compendium of Material Medica: " raw marrow is enriched blood, Yiyang of nourishing blood, strengthening the tendons and bones.Control all deficient, deaf order is dark, dizzy dysentery of deficiency type." modern pharmacology research shows: the aminoacid in Cornu Cervi Pantotrichum, the abundantest with Glycine Levels, also containing neutral sugar, glucamine, containing calcium in Cornu Cervi Pantotrichum ash, phosphorus, magnesium etc., containing volume colloid in water extraction.Heavy dose of pantocrine can decreased heart rate, and peripheral blood vessel expand, blood pressure reduction.Median dose pantocrine causes the movable obviously enhancing of isolated heart, and myocardial contraction strengthens, and increased heart rate, result makes cardiac output obviously increase.Cornu Cervi Pantotrichum has obvious lipoid peroxidization resistant and anti-stress effect.
Radix Ginseng Rubra, sweet in the mouth, micro-hardship, slightly warm in nature, returns lung, spleen, heart channel, function strongly invigorating primordial QI, and invigorating the spleen to benefit the lung, promotes the production of body fluid, Fructus Alpiniae Oxyphyllae of calming the nerves.Cure mainly vigour collapse card, lung spleen heart syndrome of deficiency of kidney-QI, the thirsty and diabetes of calentura deficiency of vital energy Tianjin wound." herbal classic ": " spasmolytic is throbbed with fear for main tonifying five ZANG-organs, peace spirit, except pathogen, and improving eyesight, happy Fructus Alpiniae Oxyphyllae." " not Lu ": " treat intestinal cold in the stomach, trusted subordinate's drum pain, costa sternales fullness due to adverse ascending of QI, cholera is told inverse, in tune, only quenches one's thirst, promoting blood circulation, broken hard long-pending, makes us not forgetting." " property of medicine opinion ": " deficient thin and weak, tell inverse lower food, only cholera unhappiness is vomitted the sound of vomiting, and tonifying five ZANG-organs six internal organs, keep god in guarantor for main the five internal organs QI-insufficiency, five kinds of strain and seven kinds of impairment." " disappears expectorant in the heart, main consumptive lung disease vomiting pus and epilepsy disease, and cold air is against upper, and the lower food of typhoid fever, suffers from that people is empty and dreaminess is diverse and confused, adds and uses it." modern pharmacology research shows: Radix Ginseng Rubra contains multiple saponin, volatile oil, aminoacid, trace element and organic acid, saccharide, the compositions such as vitamin.Radix Ginseng Rubra has excitation to central nervous system, and has inhibitory action on the contrary time a large amount of.Can strengthen excitement and the process of inhibition of animal higher nervous activity, and energy enhancing body is to the adaptive capacity of all nonspecific stimulations, feeling of fatigue (root of Radix Ginseng Rubra, stem, Ye Junneng extend the persistent period of white mice swimming) can be reduced.Direct effect is had in addition to cardiac muscle and blood vessel, generally excited when low dose, suppress time heavy dose of.Cat (or rabbit) gavage is given in 10% Radix Ginseng Rubra immersion 1 milliliter/kilogram, has some improvement to amyocardia.The recovery of certain degree is had during rewarming.Also the effect of antianaphylaxis shock and heart tonifying is had.Radix Ginseng Rubra has inhibitory action to rat myocardial cell film ATPase activity.Strengthen body to the resistance of harmful factor: the plasmodial chicken of infection can be made to avoid acute death, and the body weight of chicken also increases gradually.Can the exothermic reaction of Inhibition test animal caused by injection milk or vaccine.The ability that human body adapts to temperature Change can be strengthened.Canis familiaris L., at massive blood loss or when suffocating and be in critically ill state, is injected Radix Ginseng Rubra preparation immediately, the blood pressure of being down to very low level can be made firmly to go up.The time-to-live of the mice by Trypanosoma cruzi infection can be extended.The systemic inflammatory response that can suppress injection Oleum Terebinthinae or cause due to rabbit ear shell cold injury.Promote the healing of some experimental injury.There is vitamin antagonist B 1, B 2the effect of deficiency disease.The Healing of rabbit experiment corneal ulcer can be accelerated.Some poisonous substance (benzene, tetraethyl-lead, the three cresol phosphoric acid etc.) effect to body can be weakened.Have the hyperglycemia animal caused because of epinephrine and fall hypoglycemic effect; Improve outside symptom to diabetics decapacitation is conscious, also have slight hypoglycemic activity, and have synergism with islets of langerhans.Can promote the gonad function of animal, white mice eats Radix Ginseng Rubra in a small amount, can produce and lift tail phenomenon.At suitable dosage, also can put on weight to rabbit, make the ratio of plasma albumin and globulin increase.Hemopoietic organ, is improved the effect of anemia.Long-term taking in a small amount, can make reticuloendothelial system can be hyperfunction; Dosage is excessive, then in adverse effect.
Oletum Trogopterori bitter in the mouth, salty, sweet warm in nature, return Liver Channel.Effect promoting blood circulation and stopping pain, removing stasis to stop bleeding.Primary treatment stagnation of blood stasis pain card, stagnation of blood stasis goes out blood disorder." Bencao Jingshu ": " Oletum Trogopterori, its merit is longer than removing blood stasis promoting the circulation of blood, therefore the stagnation of all blood stasis is had a pain, puerperal blood faints, the stagnant blood centre of punch, and few abdomen after-pains, amenorrhea of bleeding, has a pain between congestion heart stomach, stasis passages through which vital energy circulates, and gas must not be gone, and attacks the cards such as sharp pain, must use.Compendium of Material Medica: " only married woman's menorrhagia, leucorrhea with bloody discharge is without cease, before tire puerperal pains associated with disorder of blood and QI, all trusted subordinates of men and women, side of body rib, few all pains of abdomen, the twinge of health blood stasis.Modern pharmacology research shows: Radix Ginseng Rubra and Oletum Trogopterori decoct compatibility, can significantly strengthen mouse immune allelotaxis, monocytic phagocytic function, hemolytic antibody is formed, to the immunologic hypofunction that cyclophosphamide causes, mouse thymus, spleen weight and hemolytic antibody are formed also obvious facilitation, meanwhile, and Radix Ginseng Rubra compatibility Oletum Trogopterori treatment gastric ulcer, chronic gastritis, pyloric cap erosive inflammation, chronic colitis all obtains good therapeutic effect, and occurs any toxic and side effects without 1 example, Papillary clinically, is also used for the treatment of tumor.
Radix Notoginseng, the micro-hardship of property, sweet, temperature, returns liver, stomach warp, function removing stasis to stop bleeding, analgesic therapy of invigorating blood circulation.For going out blood disorder, traumatic injury, swelling and pain due to blood stasis." book on Chinese herbal medicine is looked for the truth ": " Radix Notoginseng, common people only know that function is stopped blooding bitterly, hardly realize bitterly because of blood stasis then pain work, and blood stops because applying the then blood that falls apart.The bitter temperature of Radix Notoginseng abnormal smells from the patient, can in its blood stasis of blood systemization." " book on Chinese herbal medicine newly organized ": " and Radix Notoginseng, the refreshing medicine of hemostasis, no matter upper purgation blood, all have get over person outward, privately simply also to imitate, add among blood-enriching qi-invigorating medicine then more refreshing.Modern pharmacology research shows: Radix Notoginseng mainly contains saponin, flavonoid glycoside, aminoacid etc.Can humoral immune function be improved, there is analgesia, antiinflammatory, the anti-ageing effect of waiting for a long time; Obviously can treat the atrophic lesion of gastric mucosa, and can epithelioglandular atypical hyperplasia and intestinal epithelial metaplasia be reversed, there is the effect of prophylaxis of tumours.
Succinum, sweet in the mouth, property is put down, GUIXIN, liver, urinary bladder channel, function tranquillizing the mind by relieving convulsion, promoting blood circulation to remove blood stasis, inducing diuresis for treating stranguria syndrome.Primary treatment malaise, palpitation and insomnia, infantile convulsion, epilepsy, dysmenorrhea amenorrhea, trusted subordinate's twinge , lumps in the chest and abdomen, stranguria, the difficulty in urination." Mingyi Bielu ": " main settling five organs, determines soul, and disappear congestion, logical five types of stranguria." supplement to the Herbal: " hemostasis, granulation promoting, alloy skin ulcer." modern pharmacology research shows: succinic acid has central inhibitory action, can obviously reduce mice autonomic activities, extends length of one's sleep of sodium pentobarbital, and reacts rat audiogenic convulsion and white mice galvanic shock and have protective effect.
The Radix Astragali, nature and flavor are sweet, tepor, return spleen, lung meridian, air making-up and spleen enlivening, ascending up spleen-Qi and Yang, stomach reinforcing consolidating superficial resistance, inducing diuresis to remove edema, detoxification granulation promoting, and for syndrome of qi deficiency of spleen and lung, spontaneous sweating due to deficiency of QI is demonstrate,proved, deficiency of qi and blood, and skin infection difficulty is burst difficult rotten, or difficulty of a specified duration of bursting is held back." book on Chinese herbal medicine converges and says ": " medicine of wind dispelling fortune poison also for tonifying the lung spleen invigorating, real stomach arresting sweating." " Records of Tradition Chinese and Western Medicine in Combination ": " and can QI invigorating, doublely can rise gas, kindly control atmospheric subsidence in the heart." modern pharmacology research show: the Radix Astragali can raise hypoglycemia, reduce hyperglycemia; Can strengthen myocardial contraction, protection cardiovascular system, arrhythmia, coronary artery dilator and peripheral vessels, reduce blood pressure, and can reduce platelet adhesion reaction power, reduces thrombosis; Also have blood fat reducing, defying age, anti-hypoxia, radioprotective, the effect such as to protect the liver.
Sargassum salty in the mouth, cold in nature, return Liver and kidney warp.Function eliminating phlegm and softening indurated mass, inducing diuresis to remove edema.Be mainly used in treating goiter, scrofula, painful and swollen testis, phlegm retention edema.Shennong's Herbal: " the loose gas of broken knot, the hard gas of Yong Zhong mass in the abdomen, rings in abdomen up and down, lower 12 edema for main goiter gas, core under neck." Compendium of Material Medica: " and Sargassum, salty can relaxing the bowels with lubricant drugs, antiperspirant can expel the heat-evil drinking-water, therefore the goiter that can disappear, tuberculosis.Modern pharmacology research shows: Sargassum, because of containing iodide, have therapeutical effect, and to hyperthyroidism, basal metabolic rate increases temporary transient inhibitory action to the endemicity first shape enlargement that iodine deficiency causes.Sargassum fusiforme (Harv.) Setch contained in Sargassum has inhibitory action to bacillus subtilis, and Sargassum polysaccharides has inhibitory action to I herpes simplex virus type.
Semen Momordicae bitter in the mouth, micro-sweet, cool in nature, slightly poisonous, return liver, spleen, stomach warp.Effect counteracting toxic substances treats skin ulcer, dispersing swelling and dissipating binds.Primary treatment sore swollen toxin, scrofula, acute mastitis, swelling and pain of hemorrhoid, chronic eczema, tinea alba." Kaibao Bencao ": " main injured, the knot that disappears is swollen, malignant boil, granulation promoting, only lumbago, married woman's acute mastitis, swelling and pain of anus.Compendium of Material Medica: " infantile malnutrition that disappears mass in the abdomen, sharp large intestine dysentery, hemorrhoids tumor scrofula." modern pharmacology research show: momordin has antiinflammatory and hypotensive effect.
Carapax Trionycis (processed with vinegar) sweet-salty, cold in nature, returning Liver and kidney warp, effect nourishing YIN for suppressing the hyperactive YANG, bringing down a fever except steaming, hard masses softening and resolving.Primary treatment syndrome of yin deficiency of liver and kidney , lumps in the chest and abdomen.Shennong's Herbal: " main trusted subordinate's lump in the abdomen, cold and heat, remove painful abdominal mass polyp." " book on Chinese herbal medicine converges and says ": " except deficiency of YIN heat is cruel, separate the medicine of consumptive fever hectic fever due to YIN-deficiency also.Modern pharmacology research shows: Carapax Trionycis (processed with vinegar) can reduce experimental hyperthyroidism animal blood slurry cAMP content; Lymphoblastic transformation rate can be improved, extend antibody life period, strengthen immunologic function; Adrenal cortex function can be protected by report; Can hemopoietic function be promoted, improve hemoglobin; Can connective tissue proliferation be suppressed, therefore the lump that can dissipate; Prevent cell mutation effect; Also has certain sedation.
Rhizoma Pinelliae acrid in the mouth, warm in nature, slightly poisonous, return spleen, stomach, lung meridian.Effect drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, externally used detumescence pain relieving.Primary treatment damp-phlegm cold-phlegm, vomiting, epigastric oppression, blocked-up chest, globus hystericus, goiter, sucutaneous nodule, swollen ulcer drug, venom." Mingyi Bielu ": " the full knot of diabetes with polydipsia as the prominent symptom abdomen chest and diaphragm expectorant heat, cough with dyspnea, acute pain in the epigastrium, hard painful abdominal mass, seasonal epidemic pathogens vomiting, subduing inflammation, induced abortion." " medicine origin ": " control cold-phlegm and cold physique drink cold injury lung and coughing, large easing stomach-QI, except cold syndrome of the stomach, enter diet." curing mainly secret wanting " cloud: " dry stomach wets, and reduces phlegm, strengthening the spleen gastric qi, dispersing swelling and dissipating binds, removes sputum in the heart." modern pharmacology research shows: the Rhizoma Pinelliae has the effect significantly suppressing gastric secretion, and water decoction-alcohol sedimentation liquid has obvious preventive and therapeutic action to the gastric ulcer caused by many reasons.
Rhizoma Paridis is bitter, is slightly cold.Slightly poisonous, return Liver Channel.Effect heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.Primary treatment carbuncle furuncle, laryngopharynx swelling and pain, venom.Convulsion with spasms, traumatic injury.Shennong's Herbal: " steam is in abdomen, and insane disease carbuncle skin ulcer, pubic louse, lower three worms, remove snake venom for main infantile convulsion, frequent protrusion of the tongue of shaking the head." " book on Chinese herbal medicine converges and says ": " Rhizoma Paridis cooling blood, expelling wind separates the medicine of carbuncle poison also.Modern pharmacology research shows: Rhizoma Paridis has broad-spectrum antibacterial action, to dysentery bacterium, and Bacillus typhi, escherichia coli, bacillus enteritidis, bacillus pyocyaneus, staphylococcus aureus, Hemolytic streptococcus, meningococcus etc. all have inhibitory action in various degree; Stronger inhibitory action is had to Asia influenza A virus; In addition there is antitumor action.
Concha Ostreae is salty, is slightly cold, and returns liver, gallbladder, kidney channel.Function tranquillization with heavy prescription, suppressing the hyperactive liver and subsiding YANG, soft liver eliminating stagnation, restrains astringent or styptic treatment for spontaneous sweating.Be mainly used in irritability, palpitation with fear insomnia, excessive rising of liver-YANG, has a dizzy spell, sucutaneous nodule scrofula, goiter , lumps in the chest and abdomen, all cards of slippage." Haiyao Bencao, Oversea Materia Medica ": " main man's seminal emission, the weary damage of asthenia, the kidney invigorating healthy energy." essentials of Matea Medica: " salty with softening and eliminating sputum, the scrofula that disappears tuberculosis, old accumulation of blood gathers." modern pharmacology research shows: " Concha Ostreae has calm anticonvulsant effect, and it is active that Concha Ostreae (calcined) can significantly improve anti-experimental character gastric ulcer.
Scorpio acrid in the mouth, property is put down.Return Liver Channel, slightly poisonous.Function endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Be mainly used in treatment spasm to twitch, sore swollen toxin, scrofula tuberculosis, rheumatoid arthritis stubborn, intractable migraine and general headache." Kaibao Bencao ": " treat all urticarias and apoplexy and hemiplegia, mouth eye whirlpool is oblique, and tongue-tied, brothers take out sincere." Bencao Congxin ": " control all wind trembling and dizziness, infantile convulsion takes out the disease of the chilly wind wood of fainting such as sincere." modern pharmacology research shows: scorpion extraction liquid has and suppresses animal thrombosis to be formed, and anticoagulation; Scorpion body and scorpion tail preparation all have obvious analgesic activity to animal body pain or Encelialgia; Scorpio water-alcohol extraction has inhibitory action to human hepatocellular and colon cancer cell respectively.
Scolopendra acrid in the mouth, warm in nature; Slightly poisonous, return Liver Channel.Function endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Be mainly used in treatment spasm to twitch, sore swollen toxin, scrofula sucutaneous nodule, rheumatoid arthritis stubborn, intractable headache.Shennong's Herbal: " remove all poison." Compendium of Material Medica: " pediatric epilepsy scared is twitched, infantum tetanus locked mouth, erysipelas, tinea alba, scrofula, inguinal bubo, anal fistula, snake venom." modern pharmacology research show: Scolopendra decoct can improve the microcirculation of mice, and its water logging agent has inhibitory action in various degree to tubercule bacillus and various skin fungus.
Rhizoma Dioscoreae Bulbiferae bitter in the mouth, cold in nature, slightly poisonous, return liver lung meridian, function dissipating phlegm and resolving masses disappears wart, heat-clearing and toxic substances removing.Be mainly used in treating goiter, sore swollen toxin, laryngopharynx swelling and pain, venom." Kaibao Bencao ": " all evils swell skin ulcer fistula, and sore throat, Serpentis dog stings poison." " extract golden Qiu Bencao and state record ": " control cough due to lung-heat, hemoptysis, glossoncus, laryngopharynx swelling and pain." modern pharmacology research show: Rhizoma Dioscoreae Bulbiferae alcohol leaching thing water liquid has inhibitory action in various degree to multiple pathomycete.
Pseudobulbus Cremastrae Seu Pleiones sweet in the mouth, micro-pungent, cool.Return liver spleen channel.Function heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Be mainly used in treatment carbuncle furunculosis, scrofula sucutaneous nodule , mass in the abdomen mass in the abdomen.Supplement to the Herbal: " treat carbuncle skin ulcer fistula, scrofula tuberculosis etc." Compendium of Material Medica: " main furuncle swells, and counteracting toxic substances broken skin, separates all poison." modern pharmacology research shows that Bulbus Tulipae contains the multiple alkaloids such as colchicine; be anticancer active substance; research in recent years shows, the derivant Colchiceinamidum of colchicine, its active anticancer is stronger; therefore be widely used in and control breast carcinoma; cervical cancer, the esophageal carcinoma, pulmonary carcinoma; gastric cancer, the kinds cancers such as skin carcinoma.
Radix Sophorae Tonkinensis bitter in the mouth, cold in nature, slightly poisonous, return lung stomach warp.Function heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling.Be mainly used in treating laryngopharynx swelling and pain, gingival swelling and pain." Bencao Tujing ": " adopt root use, moderns cun cut containing it, extremely wonderful to separate laryngopharynx swelling and pain." essentials of Matea Medica: " and pathogenic heat are detoxified, go large intestine wind heat, the pharynx juice contained, only laryngalgia, tooth swells, toothache." modern pharmacology research show; Radix Sophorae Tonkinensis has antitumaous effect, contained matrine, oxymatrine to experimental tumor all in inhibitory action; Have antiulcer action, energy gastric acid secretion inhibiting, has obvious repair to Experimental oral ulcer.
Realgar acrid in the mouth, warm in nature, slightly poisonous.Return liver, stomach, large intestine channel.Effect is detoxified, virus killing.Carbuncle furuncle, eczema scabies, worm venom.Shennong's Herbal: " malignant boil, cellulitis hemorrhoid, dead flesh, kills hundred insect poison for main cold and heat, scrofula." " Japan hanako materia medica ": " control scabies, ailment said due to cold or exposure epilepsy, haze miasma, all snakeworms, dog beast wound is stung." modern pharmacology research show: Realgar water logging agent has inhibitory action in various degree to multiple pathogenic dermatophytess such as trichophytons in vitro.Realgar can also pass through inducing apoptosis of tumour cell, and T suppression cell DNA synthesizes, and the many factors such as the cellular immune function of enhancing body play its antitumor action.
Radix Glycyrrhizae sweet in the mouth, property is put down, GUIXIN lung spleen channel, function invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.For deficiency of heart-QI, irregularly intermittent and regularly intermittent pulse, severe palpitation, syndrome of deficiency of spleen qi, cough with asthma, the anxious pain of gastral cavity abdomen extremity contraction, pathopyretic ulcer, laryngopharynx swelling and pain, medicine food is poisoning, the mediation property of medicine." Mingyi Bielu ": " warming the middle warmer and descending qi, stuffy sensation with restlessness is losed heart, and hinders dirty cough." " book on Chinese herbal medicine converges and says ": " and with middle QI invigorating, the medicine of tonify deficiency removing toxic substances." modern pharmacology research show; Radix Glycyrrhizae has antiulcer, gastric acid secretion inhibiting, alleviates gastrointestinal smooth muscular spasm and analgesic activity; Have antibacterial, antiviral, antiinflammatory, anti-allergic effects.
The each crude drug compatibility of oral medicament composition of the present invention is reasonable, containing Multiple Antibodies in Placenta Hominis globulin products, and long-term employing and passive immunity clinically.Also containing interferon in Human plactnta, have and suppress multiple virus to the effect of people's cell, and containing the macroglobulin of influenza virus can be suppressed, claim β-inhibitive factor.Therefore the antibody of this ectoplacenta also containing some infectious disease anti-be a kind of immunosuppressant, containing multiple enzyme system in Placenta Hominis, and enhancing body resistance, tool immunity and anti-allergic effects; Aminoacid in Cornu Cervi Pantotrichum, the abundantest with Glycine Levels, also containing neutral sugar, glucamine, containing calcium in Cornu Cervi Pantotrichum ash, phosphorus, magnesium etc., containing volume colloid in water extraction.Heavy dose of pantocrine makes heart contracting amplitude reduce, decreased heart rate, and peripheral blood vessel is expanded, and blood pressure reduces.Median dose pantocrine causes the movable obviously enhancing of isolated heart, and heart contracting amplitude increases, and increased heart rate, result makes heart pulse output and percentage output all increase.Cornu Cervi Pantotrichum has obvious lipoid peroxidization resistant and anti-stress effect; Radix Notoginseng mainly contains saponin, flavonoid glycoside, aminoacid etc.Can humoral immune function be improved, there is analgesia, antiinflammatory, the anti-ageing effect of waiting for a long time; Obviously can treat the atrophic lesion of gastric mucosa, and can epithelioglandular atypical hyperplasia and intestinal epithelial metaplasia be reversed, there is the effect of prophylaxis of tumours; The Radix Astragali can raise hypoglycemia, reduces hyperglycemia; Can strengthen myocardial contraction, protection cardiovascular system, arrhythmia, coronary artery dilator and peripheral vessels, reduce blood pressure, and can reduce platelet adhesion reaction power, reduces thrombosis; Also have blood fat reducing, defying age, anti-hypoxia, radioprotective, the effect such as to protect the liver; Radix Ginseng Rubra contains multiple saponin, volatile oil, aminoacid, trace element and organic acid, saccharide, the compositions such as vitamin.Radix Ginseng Rubra has excitation to central nervous system, and has inhibitory action on the contrary time a large amount of.Excitement and the process of inhibition of animal higher nervous activity can be strengthened.And energy enhancing body is to the adaptive capacity of all nonspecific stimulations, feeling of fatigue (root of Radix Ginseng Rubra, stem, Ye Junneng extend the persistent period of white mice swimming) can be reduced.Direct effect is had in addition to cardiac muscle and blood vessel, generally excited when low dose, suppress time heavy dose of.Cat (or rabbit) gavage is given in 10% Radix Ginseng Rubra immersion 1 milliliter/kilogram, has some improvement to amyocardia.The recovery of certain degree is had during rewarming.Also the effect of antianaphylaxis shock and heart tonifying is had.Radix Ginseng Rubra has inhibitory action to rat myocardial cell film ATPase activity.Strengthen body to the resistance of harmful factor: the plasmodial chicken of infection can be made to avoid acute death, and the body weight of chicken also increases gradually.Can the exothermic reaction of Inhibition test animal caused by injection milk or vaccine.The ability that human body adapts to temperature Change can be strengthened; It is monarch drug altogether that five medicines share, and plays strengthening the body resistance altogether, improves immunity, effect of resistance; Succinic acid has central inhibitory action, can obviously reduce mice autonomic activities, extends length of one's sleep of sodium pentobarbital, and reacts rat audiogenic convulsion and white mice galvanic shock and have protective effect; Radix Ginseng Rubra and Oletum Trogopterori decoct compatibility, can significantly strengthen mouse immune allelotaxis, monocytic phagocytic function, hemolytic antibody is formed, to the immunologic hypofunction that cyclophosphamide causes, mouse thymus, spleen weight and hemolytic antibody are formed also obvious facilitation, meanwhile, and Radix Ginseng Rubra compatibility Oletum Trogopterori treatment gastric ulcer, chronic gastritis, pyloric cap erosive inflammation, chronic colitis all obtains good therapeutic effect, and occurs any toxic and side effects without 1 example, Papillary clinically, is also used for the treatment of tumor; Sargassum, because of containing iodide, have therapeutical effect, and to hyperthyroidism, basal metabolic rate increases temporary transient inhibitory action to the endemicity first shape enlargement that iodine deficiency causes.Sargassum fusiforme (Harv.) Setch contained in Sargassum has inhibitory action to bacillus subtilis, and Sargassum polysaccharides has inhibitory action to I herpes simplex virus type; Carapax Trionycis (processed with vinegar) can reduce experimental hyperthyroidism animal blood slurry cAMP content; Lymphoblastic transformation rate can be improved, extend antibody life period, strengthen immunologic function; Adrenal cortex function can be protected by report; Can hemopoietic function be promoted, improve hemoglobin; Can connective tissue proliferation be suppressed, therefore the lump that can dissipate; Prevent cell mutation effect; Also has certain sedation; It is ministerial drug altogether that four medicines share, and on the basis strengthening monarch drug effect, increase is got rid of evils, the merit of hard masses softening and resolving, strengthening vital QI to eliminate pathogenic factors.Momordin has antiinflammatory and hypotensive effect; The Rhizoma Pinelliae has the effect significantly suppressing gastric secretion, and water decoction-alcohol sedimentation liquid has obvious preventive and therapeutic action to the gastric ulcer caused by many reasons; Concha Ostreae has calm anticonvulsant effect, and it is active that Concha Ostreae (calcined) can significantly improve anti-experimental character gastric ulcer; Scorpion extraction liquid has suppression animal thrombosis to be formed, and anticoagulation; Scorpion body and scorpion tail preparation all have obvious analgesic activity to animal body pain or Encelialgia; Scorpio water-alcohol extraction has inhibitory action to human hepatocellular and colon cancer cell respectively; Scolopendra decoct can improve the microcirculation of mice, and its water logging agent has inhibitory action in various degree to tubercule bacillus and various skin fungus; Rhizoma Dioscoreae Bulbiferae alcohol leaching thing water liquid has inhibitory action in various degree to multiple pathomycete; Medicine is adjuvant drug altogether, is intended to strengthen monarch drug and ministerial drug; Pseudobulbus cremastrae seu pleiones contains the multiple alkaloids such as colchicine, and be anticancer active substance, research in recent years shows, the derivant Colchiceinamidum of colchicine, its active anticancer is stronger, therefore is widely used in and controls breast carcinoma, cervical cancer, the esophageal carcinoma, pulmonary carcinoma, gastric cancer, the kinds cancers such as skin carcinoma; This several medicine enters liver, stomach warp, has effect that stomach led by priming, makes the efficacy of a drug act on esophagus and intestinal internal organs.All medicines share to have anticancerly attacks knot, and softening the hard mass falls apart the effect of tumor, therefore is adjuvant drug altogether, strengthens the vigor of monarch drug and ministerial drug.Radix Sophorae Tonkinensis has antitumaous effect, contained matrine, oxymatrine to experimental tumor all in inhibitory action; Have antiulcer action, energy gastric acid secretion inhibiting, has obvious repair to Experimental oral ulcer; Realgar water logging agent has inhibitory action in various degree to multiple pathogenic dermatophytess such as trichophytons in vitro.Realgar can also pass through inducing apoptosis of tumour cell, and T suppression cell DNA synthesizes, and the many factors such as the cellular immune function of enhancing body play its antitumor action; Radix Glycyrrhizae has antiulcer, gastric acid secretion inhibiting, alleviates gastrointestinal smooth muscular spasm and analgesic activity; Have antibacterial, antiviral, antiinflammatory, anti-allergic effects.The mutual compatibility of above three medicine, altogether for making medicine, can alleviate toxicity, reduces toxic and side effects, strengthens effect of monarch drug ministerial drug simultaneously.All medicine compatibilities play vital base and primordial QI consolidating altogether, hold up beneficial healthy energy, anticancer merit of getting rid of evils.
Positive beneficial effect of the present invention:
1. oral medicament composition compatibility of the present invention is reasonable, precise and appropriate, meets " monarch " principle, meets esophageal carcinoma pathogenesis.
2. the Chinese medicine composition of the vital base and primordial QI consolidating treatment esophageal carcinoma of the present invention adopts the method for traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors, and energy strongly invigorating primordial QI, improves body immunity on the one hand, strengthens the ability of resisting pathogen; On the other hand, blood circulation promoting and blood stasis dispelling, dissipating phlegm and resolving masses, attacks the stasis of blood by numbness.Be particularly useful for treatment asthenic healthy qi with pathogen lingering type or the dysphagic patient of expectorant knot blood stasis type, the esophageal carcinoma namely on modern medicine, with having a delicate constitution, the patient with esophageal carcinoma that immunity of organisms is low.
3. the traditional Chinese medicine composition for treating Be very effective of the vital base and primordial QI consolidating treatment esophageal carcinoma of the present invention, total effective rate is up to 80%, and clinical cure rate is up to 60%.
4. the present invention is except being used for the treatment of the esophageal carcinoma, also can be used for the treatment of other digestive system tumors, and effect is also fine.
Detailed description of the invention
Below in conjunction with some detailed description of the invention, the present invention is further described.
Embodiment 1
A Chinese medicine composition for the vital base and primordial QI consolidating treatment esophageal carcinoma, comprises the crude drug of following parts by weight: Placenta Hominis 10 parts, 10 parts, Cornu Cervi Pantotrichum, Radix Ginseng Rubra 10 parts, Oletum Trogopterori 10 parts, Radix Notoginseng 10 parts, succinum 10 parts, the Radix Astragali 10 parts, Sargassum 10 parts, Semen Momordicae 10 parts, Carapax Trionycis (processed with vinegar) 10 parts, Rhizoma Pinelliae 10 parts, Rhizoma Paridis 5 parts, Concha Ostreae 10 parts, Scorpio 10 parts, Scolopendra 10 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Pseudobulbus Cremastrae Seu Pleiones 10 parts, Radix Sophorae Tonkinensis 10 parts, Realgar 5 parts, Radix Glycyrrhizae 10 parts.
The preparation method of above-mentioned Chinese medicine composition comprises the following steps:
(1) get crude drug to add in the ethanol of 5 times amount and soak 1h, heating extraction 3 times, each 1h, merge extractive liquid, gets supernatant after leaving standstill, and then 140 orders filter, be the ultrafiltration post ultrafiltration of 5000 again through the molecular weight that dams, ultrafiltrate is evaporated to the extractum of when relative density is 70 DEG C 1.15, stand for standby use, is component A;
(2) medicinal residues of the crude drug crossed by step (1) ethanol extraction add 8 times amount distilled water, heating and refluxing extraction 2 times, each lh, merge extractive liquid, and leaving standstill, is B component;
(3) by the merging of component A and B component, sucking filtration, then being evaporated to liquor strength is 1.0g/mL, then through macroporous adsorptive resins absorption, with the distilled water eluting of 8 times of resin column volumes, use the dehydrated alcohol eluting of 5 times of resin column volumes again, collect ethanol elution, remove solvent, obtain medicated powder, incapsulate, every 1.0g.
Embodiment 2
A Chinese medicine composition for the vital base and primordial QI consolidating treatment esophageal carcinoma, comprises the crude drug of following parts by weight: Placenta Hominis 25 parts, 25 parts, Cornu Cervi Pantotrichum, Radix Ginseng Rubra 25 parts, Oletum Trogopterori 15 parts, Radix Notoginseng 30 parts, succinum 20 parts, the Radix Astragali 30 parts, Sargassum 40 parts, Semen Momordicae 15 parts, Carapax Trionycis (processed with vinegar) 30 parts, Rhizoma Pinelliae 20 parts, Rhizoma Paridis 15 parts, Concha Ostreae 30 parts, Scorpio 15 parts, Scolopendra 15 parts, Rhizoma Dioscoreae Bulbiferae 20 parts, Pseudobulbus Cremastrae Seu Pleiones 15 parts, Radix Sophorae Tonkinensis 15 parts, Realgar 10 parts, Radix Glycyrrhizae 30 parts.
The preparation method of above-mentioned oral traditional Chinese medicine composition comprises the following steps:
(1) get crude drug to add in the ethanol of 6 times amount and soak 2h, heating extraction 2 times, each 2h, merge extractive liquid, gets supernatant after leaving standstill, and then 120 orders filter, be the ultrafiltration post ultrafiltration of 8000 again through the molecular weight that dams, ultrafiltrate is evaporated to the extractum of when relative density is 60 DEG C 1.18, stand for standby use, is component A;
(2) medicinal residues of the crude drug crossed by step (1) ethanol extraction add 10 times amount distilled water, heating and refluxing extraction 3 times, each 2h, merge extractive liquid, and leaving standstill, is B component;
(3) by the merging of component A and B component, sucking filtration, then being evaporated to liquor strength is 1.02g/mL, then through macroporous adsorptive resins absorption, loses ionized water or distilled water eluting with 10 times of resin column volumes, use the dehydrated alcohol eluting of 6 times of resin column volumes again, collect ethanol elution, remove solvent, obtain medicated powder, incapsulate, every 0.6g.
Embodiment 3
An oral medicament composition for the vital base and primordial QI consolidating treatment esophageal carcinoma, comprises the crude drug of following parts by weight: Placenta Hominis 15 parts, 15 parts, Cornu Cervi Pantotrichum, Radix Ginseng Rubra 20 parts, Oletum Trogopterori 12 parts, Radix Notoginseng 20 parts, succinum 15 parts, the Radix Astragali 30 parts, Sargassum 30 parts, Semen Momordicae 12 parts, Carapax Trionycis (processed with vinegar) 20 parts, Rhizoma Pinelliae 15 parts, Rhizoma Paridis 12 parts, Concha Ostreae 20 parts, Scorpio 12 parts, Scolopendra 12 parts, Rhizoma Dioscoreae Bulbiferae 15 parts, Pseudobulbus Cremastrae Seu Pleiones 12 parts, Radix Sophorae Tonkinensis 10 parts, Realgar 10 parts, Radix Glycyrrhizae 20 parts.
The preparation method of above-mentioned Chinese medicine composition comprises the following steps:
(1) get crude drug to add in the ethanol of 6 times amount and soak 2h, heating extraction 3 times, each 2h, merge extractive liquid, gets supernatant after leaving standstill, and then 140 orders filter, be the ultrafiltration post ultrafiltration of 10000 again through the molecular weight that dams, ultrafiltrate is evaporated to the extractum of when relative density is 70 DEG C 1.18, stand for standby use, is component A;
(2) medicinal residues of the crude drug crossed by step (1) ethanol extraction add 12 times amount distilled water, heating and refluxing extraction 3 times, each 2h, merge extractive liquid, and leaving standstill, is B component;
(3) by the merging of component A and B component, sucking filtration, then being evaporated to liquor strength is 1.05g crude drug/mL, then through macroporous adsorptive resins absorption, loses ionized water or distilled water eluting with 12 times of resin column volumes, use the dehydrated alcohol eluting of 6 times of resin column volumes again, collect ethanol elution, remove solvent, obtain medicated powder, incapsulate, every 1.0g.
Embodiment 4
A Chinese medicine composition for the vital base and primordial QI consolidating treatment esophageal carcinoma, comprises the crude drug of following parts by weight: Placenta Hominis 30 parts, 30 parts, Cornu Cervi Pantotrichum, Radix Ginseng Rubra 30 parts, Oletum Trogopterori 20 parts, Radix Notoginseng 35 parts, succinum 20 parts, the Radix Astragali 35 parts, Sargassum 45 parts, Semen Momordicae 20 parts, Carapax Trionycis (processed with vinegar) 35 parts, Rhizoma Pinelliae 25 parts, Rhizoma Paridis 15 parts, Concha Ostreae 35 parts, Scorpio 20 parts, Scolopendra 20 parts, Rhizoma Dioscoreae Bulbiferae 15 parts, Pseudobulbus Cremastrae Seu Pleiones 20 parts, Radix Sophorae Tonkinensis 20 parts, Realgar 15 parts, Radix Glycyrrhizae 45 parts.
The preparation method of above-mentioned Chinese medicine composition comprises the following steps:
(1) get crude drug to add in the ethanol of 5 times amount and soak 2h, heating extraction 3 times, each 2h, merge extractive liquid, gets supernatant after leaving standstill, and then 140 orders filter, be the ultrafiltration post ultrafiltration of 10000 again through the molecular weight that dams, ultrafiltrate is evaporated to the extractum of when relative density is 70 DEG C 1.2, stand for standby use, is component A;
(2) medicinal residues of the crude drug crossed by step (1) ethanol extraction add 10 times amount distilled water, heating and refluxing extraction 3 times, each 2h, merge extractive liquid, and leaving standstill, is B component;
(3) by the merging of component A and B component, sucking filtration, then being evaporated to liquor strength is 1.1g crude drug/mL, then through macroporous adsorptive resins absorption, loses ionized water or distilled water eluting with 12 times of resin column volumes, use the dehydrated alcohol eluting of 6 times of resin column volumes again, collect ethanol elution, remove solvent, obtain medicated powder, incapsulate, every 1.0g.
Embodiment 5
A Chinese medicine composition for the vital base and primordial QI consolidating treatment esophageal carcinoma, comprises the crude drug of following parts by weight: Placenta Hominis 10 parts, 10 parts, Cornu Cervi Pantotrichum, Radix Ginseng Rubra 10 parts, Oletum Trogopterori 10 parts, Radix Notoginseng 15 parts, succinum 15 parts, the Radix Astragali 15 parts, Sargassum 15 parts, Semen Momordicae 10 parts, Carapax Trionycis (processed with vinegar) 15 parts, Rhizoma Pinelliae 10 parts, Rhizoma Paridis 10 parts, Concha Ostreae 10 parts, Scorpio 10 parts, Scolopendra 10 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Pseudobulbus Cremastrae Seu Pleiones 10 parts, Radix Sophorae Tonkinensis 10 parts, Realgar 8 parts, Radix Glycyrrhizae 15 parts.
The preparation method of above-mentioned Chinese medicine composition comprises the following steps:
(1) by various crude drug roguing, dry, be ground into granule, soak 1h: soaked raw material is put in multi-function extractor and decocts with water 2 times, add up the water of medical material 8 times amount for the first time, decoct 1.5h, get decocting liquid, filter, second time adds the water of total amount 3 times amount, decoct lh, get twice decocting liquid mixing, filter;
(2) be the concentrated solution of 1.2 by relative density during the filtrate reduced in volume to 80 of filtration DEG C, set to 0-5 DEG C of deepfreeze 24h;
(3) cold preservation liquid is added kieselguhr, filter, filtrate reduced in volume, is dried to powder, incapsulates, every 0.8g.
Embodiment 6
Placenta Hominis 10-25 part, Cornu Cervi Pantotrichum 10-25 part, Radix Ginseng Rubra 10-25 part, Oletum Trogopterori 10-15 part, Radix Notoginseng 15-30 part, succinum 15-20 part, Radix Astragali 15-30 part, Sargassum 15-40 part, Semen Momordicae 10-15 part, Carapax Trionycis (processed with vinegar) 15-30 part, Rhizoma Pinelliae 10-20 part, Rhizoma Paridis 10-15 part, Concha Ostreae 10-30 part, Scorpio 10-15 part, Scolopendra 10-15 part, Rhizoma Dioscoreae Bulbiferae 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 10-15 part, Radix Sophorae Tonkinensis 10-15 part, Realgar 8-10 part, Radix Glycyrrhizae 15-30 part.
A Chinese medicine composition for the vital base and primordial QI consolidating treatment esophageal carcinoma, comprises the crude drug of following parts by weight: Placenta Hominis 25 parts, 20 parts, Cornu Cervi Pantotrichum, Radix Ginseng Rubra 20 parts, Oletum Trogopterori 15 parts, Radix Notoginseng 25 parts, succinum 15 parts, the Radix Astragali 30 parts, Sargassum 30 parts, Semen Momordicae 15 parts, Carapax Trionycis (processed with vinegar) 20 parts, Rhizoma Pinelliae 15 parts, Rhizoma Paridis 15 parts, Concha Ostreae 20 parts, Scorpio 15 parts, Scolopendra 15 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Pseudobulbus Cremastrae Seu Pleiones 15 parts, Radix Sophorae Tonkinensis 10 parts, Realgar 8 parts, Radix Glycyrrhizae 25 parts.
The preparation method of above-mentioned Chinese medicine composition comprises the following steps:
(1) by various crude drug roguing, dry, be ground into granule, soak 2h: soaked raw material is put in multi-function extractor and decocts with water 3 times, add up the water of medical material 10 times amount for the first time, decoct 2h, get decocting liquid, filter, second time adds the water of total amount 5 times amount, decoct 1.2h, get twice decocting liquid mixing, filter;
(2) be the concentrated solution of 1.1 by relative density during the filtrate reduced in volume to 70 of filtration DEG C, set to 0-5 DEG C of deepfreeze 20h;
(3) cold preservation liquid is added kieselguhr, filter, filtrate reduced in volume, is dried to powder, incapsulates, every 0.5g.
clinical trial
L, clinical data
1.1 physical data
From 2009 so far, altogether collect 100 routine esophageal carcinoma expectant treatment patients, wherein male 44 example, women 56 example, age 50-73 year, 61.5 years old mean age; Course of disease 0.5-3, the course of disease is less than 1 year person 30 example, 1-2 person 36 example, 2-3 person 34 example.
1.2 curative effect determinate standard
The curative effect determinate standard of the new Chinese medicine treatment esophageal carcinoma of " the new Chinese medicine guideline of clinical investigations " developed and published according to " Chinese medical disease Standardization of diagnosis and curative effect " and the health ministry in 2002 of State Administration of Traditional Chinese Medicine's up-to-date issue in 2012 is diagnosed, and curative effect determinate standard is:
Recovery from illness: life span reaches more than 5 years, without clinical malaise symptoms, does not need to take any chemotherapeutics, dietetic life recovers normal, and the mental status is good.
Effective: body function is normal, diet take a turn for the better, without significant discomfort symptom, daily life still can, do not need to take Western medicine chemotherapeutics, and life span is at 3-5.
Effective: diet is improved, energy half liquid food drink milk steamed bread, slightly hard food of can not taking food.The mental status still can, life substantially can take care of oneself, do not need to take Western medicine chemotherapeutics, life span is at 1-3.
Invalid: compare with before treatment, each side is all not improved.
2, Therapeutic Method
2.1 case groupings
By random principle, above case is divided into experimental group and matched group.Experimental group takes traditional Chinese medicine composition for treating of the present invention orally.Treatment group 50 example of the present invention, wherein man 15 example, female 35 example; Age 50-73 year, average 61.5 years old, average course of disease 1.75; Matched group 50 example, wherein man 29 example, female 21 example; Age 50-64 year, average 57 years old, average course of disease 1.5 years.Two groups of data statistics analyse zero differences.
2.2 Therapeutic Method
Experimental group: endo-medicine: the embodiment of the present invention 1 oral medicament composition, every day 2-3 time, each 1-3 grain 1 month is a course for the treatment of.
Matched group: application Western medicine antitumor drug treatment, oxaliplatin 130mg/ml, to add in the glucose solution of 250 ~ 500ml5% infusion 2 ~ 6 hours.When not having major toxicity to occur, (21 days) administration in every 3 weeks 1 time, 6 months is a course for the treatment of, Shandong pharmacy, specification: 50mg.
3, clinical test results is in table 1.
Table 1 clinical test results
Group Number of cases Clinical recovery Effective Effectively Invalid Cure rate (%) Total effective rate (%)
Treatment group 50 19 15 6 10 38 80
Matched group 50 8 12 6 24 16 52
Two groups of obvious effective rate comparitive study, p<0.05, has significant difference, shows that the curative effect of the orally taken for curing esophageal carcinoma of the present invention is better than the Therapeutic Method of conventional western medicine chemotherapy.
model case
1. the Meng, man, 57 years old, peasant.First visit on August 12 in 2009, medical history: more than Progressive symmetric erythrokeratodermia dysphagia June, patient is in April, 2009 pharynx food pain, and hard food is choked, increase the weight of gradually, become thin obviously, after 3 months, the white mucus of saliva, the readme pain over the chest and back, is hard and dry, glutted discomfort after food, tired from head to foot, liquid semiliquid diet of now taking food is slightly difficult, at the beginning of 2009 8 months, to local people's hospital admission, make a definite diagnosis through barium meal, be diagnosed as mid-thoracic esophagus, after operative treatment, effect is undesirable, and patient thinks expectant treatment, here treatment then.Inquiring: his father is dead before 20 years because suffering from " food of choking is sick ", and usually have a delicate constitution, dislike the product that food is cold and cool, more than 15 years of stomachache with cool feeling, shallow complexion, light red tongue is dark, and tongue is slightly light less, deficient and stringy pulse.Pattern of syndrome is: first deficiency of vital energy declines, pathogenic stasis block esophagus.The embodiment of the present invention 4 Chinese medicine composition for oral administration, every day 3 times, each 2; Medication is after 1 month, and hypopharynx stop alleviates, and tell a little mucus, the pain over the chest and back alleviates, and feels weak with it and alleviates.Adhere to that treatment is after 5 months, stomachache with cool feeling alleviates, and other symptoms disappear substantially, swallows common food smooth, and the pain over the chest and back disappears, and following the service 3 months consolidate curative effect, visit 3 years, patient clinical transference cure, and can carry out general housework activity, all are all right.
2. Zhao, 61 years old, man, workman, enters my institute's treatment on July 10th, 2010, medical history: Progressive symmetric erythrokeratodermia dysphagia, more than month, increase the weight of six days, the second half year in 2009, even when having a meal have food of choking to stop, must rush namely by water, throat pain simultaneously, health is become thin gradually, and it is many to tell mucus, the pain over the chest and back, large loose stool, digestive function of spleen and stomach is poor usually, and fear of cold is afraid of cold.Check: pale complexion, become thin in cachexia, mouth glues tasteless, light red tongue, tongue body atrophy, thready and weak pulse.Barium meal x-ray is shown as lower 1/3 the 6th vertebral body in esophagus has the long filling defect of 3cm with eminence, and mucosa slightly disorderly, is diagnosed as the medullary esophageal carcinoma.Dialectical: deficiency of qi and blood, body function is low.The embodiment of the present invention 1 Chinese medicine composition for oral administration, every day 3 times, each 2; Treat five months transference cures, tell glutinous expectorant and reduce, half liquid food of taking food, the pain over the chest and back disappears, and spiritual antisecosis still can.Check after 1 year, X sheet display mucosa is fine and smooth, and esophagus smooth muscle is smooth, follows up a case by regular visits to 2 years half, occurs without any unfavorable condition, and dietetic life and common people are substantially the same.
3. Cui, female, 65 years old, retired cadre, on October 14th, 2010 was esophageal carcinoma middle and advanced stage at local people's hospital diagnosis, then performs the operation, and postoperative effect is very optimistic, mastery of being in after radiotherapy chemotherapy, and most multipotency work 1 year is informed by school.Its subband its carry out the treatment of my institute, medical history: more than Progressive symmetric erythrokeratodermia dysphagia May, appetite reduces, and tells white sticky expectorant, body weight rapid drawdown, and to liquid food difficulty of taking food at the beginning of 10 months this year, have a medical check-up: shallow complexion, facial muscle are become thin totally, pale tongue, few tongue.Deep and weak pulse is puckery.Dialectical: first deficiency of vital energy declines, zang-fu disharmony.The embodiment of the present invention 2 Chinese medicine composition for oral administration, every day 3 times, each 2; Treat five months, X sheet contrast display focus is reduced into 2cm, continual cure, and after 1 year, clinical symptoms disappears substantially, general diet of taking food, and spiritual strength returns to the front level of disease, can manage general housework.Follow up a case by regular visits to so far, all are normal for patient.
4. Zhai, female, 66 years old, street cleaner, my institute's treatment of 3 monthly incomes in 2009, medical history: Progressive symmetric erythrokeratodermia dysphagia 5 months, before half a year, feed has sense of choking, and increases the weight of gradually, then tells white sticky foam, the pain over the chest and back, x-ray barium meal examination, distal esophagus has 6cm narrow stiff, and mucosa is coarse, wriggling slows down, and is diagnosed as esophageal carcinoma mid-term.Have a medical check-up, face light yellow complexion, body of the tongue atrophy, the few tongue of light red tongue, deep and faint pulse.Dialectical; Qi and blood deficiency, phlegm stagnation in collateral.Because patient is reluctant to require the conservative treatment that takes traditional Chinese medicine by operative treatment.The embodiment of the present invention 5 Chinese medicine composition for oral administration, every day 3 times, each 3; After taking medicine 3 months, symptom has clear improvement, following the service 5 months, and X sheet display mild focal reduces, and mucosa mobility increases.Follow up a case by regular visits to 1 year half, x-ray inspection, focus is atresia, and life is basic recovers normal, and check in 2013 is good.Follow up a case by regular visits to so far in order.

Claims (5)

1. the Chinese medicine composition of an element culturing fixed folder treatment esophageal carcinoma, it is characterized in that, this Chinese medicine composition comprises the crude drug of following parts by weight: Placenta Hominis 10-30 part, Cornu Cervi Pantotrichum 10-30 part, Radix Ginseng Rubra 10-30 part, Oletum Trogopterori 10-20 part, Radix Notoginseng 10-35 part, succinum 10-20 part, Radix Astragali 10-35, Sargassum 10-45 part, Semen Momordicae 10-20 part, Carapax Trionycis (processed with vinegar) 10-35 part, Rhizoma Pinelliae 10-25 part, Rhizoma Paridis 5-15 part, Concha Ostreae 10-35 part, Scorpio 10-20 part, Scolopendra 10-20 part, Rhizoma Dioscoreae Bulbiferae 10-15 part, Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Radix Sophorae Tonkinensis 10-20 part, Realgar 5-15 part, Radix Glycyrrhizae 10-45 part.
2. the Chinese medicine composition of the element culturing fixed folder treatment esophageal carcinoma according to claim 1, it is characterized in that, described Chinese medicine composition comprises the crude drug of following parts by weight: Placenta Hominis 10-25 part, Cornu Cervi Pantotrichum 10-25 part, Radix Ginseng Rubra 10-25 part, Oletum Trogopterori 10-15 part, Radix Notoginseng 15-30 part, succinum 15-20 part, Radix Astragali 15-30 part, Sargassum 15-40 part, Semen Momordicae 10-15 part, Carapax Trionycis (processed with vinegar) 15-30 part, Rhizoma Pinelliae 10-20 part, Rhizoma Paridis 10-15 part, Concha Ostreae 10-30 part, Scorpio 10-15 part, Scolopendra 10-15 part, Rhizoma Dioscoreae Bulbiferae 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 10-15 part, Radix Sophorae Tonkinensis 10-15 part, Realgar 8-10 part, Radix Glycyrrhizae 15-30 part.
3. the Chinese medicine composition of the element culturing fixed folder treatment esophageal carcinoma according to claim 1, it is characterized in that, described Chinese medicine composition comprises the crude drug of following parts by weight: Placenta Hominis 15 parts, 15 parts, Cornu Cervi Pantotrichum, Radix Ginseng Rubra 20 parts, Oletum Trogopterori 12 parts, Radix Notoginseng 20 parts, succinum 15 parts, the Radix Astragali 30 parts, Sargassum 30 parts, Semen Momordicae 12 parts, Carapax Trionycis (processed with vinegar) 20 parts, Rhizoma Pinelliae 15 parts, Rhizoma Paridis 12 parts, Concha Ostreae 20 parts, Scorpio 12 parts, Scolopendra 12 parts, Rhizoma Dioscoreae Bulbiferae 15 parts, Pseudobulbus Cremastrae Seu Pleiones 12 parts, Radix Sophorae Tonkinensis 10 parts, Realgar 10 parts, Radix Glycyrrhizae 20 parts.
4. the Chinese medicine composition preparation method of the element culturing fixed folder treatment esophageal carcinoma according to claim 1, is characterized in that, comprise the following steps:
(1) get crude drug to add in the ethanol of 5-6 times amount and soak 1.5-2h, heating extraction 2-3 time, each 1.5-2h, merge extractive liquid, then 100-140 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, and ultrafiltrate is evaporated to the extractum of 1.15-1.20g/mL when relative density is 60-70 DEG C, stand for standby use is component A;
(2) medicinal residues of the crude drug crossed by step (1) ethanol extraction add 5-10 times amount distilled water, heating and refluxing extraction 2-3 time, at every turn l.5-2h, merge extractive liquid, leaving standstill, is B component;
(3) by the merging of component A and B component, sucking filtration, then being evaporated to liquor strength is 1.0-1.1g/mL, then through macroporous adsorptive resins absorption, with the distilled water eluting of 8-12 times of resin column volume, again with the dehydrated alcohol eluting of 5-6 times of resin column volume, collect ethanol elution, remove solvent, obtain medicated powder, incapsulate, every 0.5-1.0g.
5. the Chinese medicine composition preparation method of the element culturing fixed folder treatment esophageal carcinoma according to claim 1, is characterized in that, comprise the following steps:
(1) by various crude drug roguing, dry, be ground into granule, soak 1.5-2h: soaked raw material is put in multi-function extractor and decocts with water 2-3 time, the water of first time totalling medical material 5-10 times amount, decoct 1.5-2h, get decocting liquid, filter, second time adds the water of total amount 4-6 times amount, decoct l-1.2h, get twice decocting liquid mixing, filter;
(2) be the concentrated solution of 1.10-1.20 by the filtrate reduced in volume of filtration to relative density during 70-80 DEG C, set to 0-5 DEG C of deepfreeze 20-24h;
(3) step (2) cold preservation liquid is added kieselguhr, filter, filtrate reduced in volume, is dried to powder, incapsulates, every 0.5-1.0g.
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108339100A (en) * 2018-03-15 2018-07-31 天津白大夫健康管理有限公司 A kind of dissipating bind granular recipe
CN109498738A (en) * 2019-01-08 2019-03-22 王茂泓 It is a kind of for treating deficient Chinese medicine composition
CN110638850A (en) * 2019-10-10 2020-01-03 山东汤液草堂医药科技有限公司 Traditional Chinese medicine composition for enhancing immunity and mainly treating various chronic difficult and complicated diseases and preparation method thereof

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CN102973805A (en) * 2012-11-25 2013-03-20 青州市经济开发区卫生院 Traditional Chinese medicine composition for treating esophagus cancer
CN103705897A (en) * 2014-01-03 2014-04-09 陈延玲 Cancer pain-relieving plaster

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CN102973805A (en) * 2012-11-25 2013-03-20 青州市经济开发区卫生院 Traditional Chinese medicine composition for treating esophagus cancer
CN103705897A (en) * 2014-01-03 2014-04-09 陈延玲 Cancer pain-relieving plaster

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108339100A (en) * 2018-03-15 2018-07-31 天津白大夫健康管理有限公司 A kind of dissipating bind granular recipe
CN109498738A (en) * 2019-01-08 2019-03-22 王茂泓 It is a kind of for treating deficient Chinese medicine composition
CN110638850A (en) * 2019-10-10 2020-01-03 山东汤液草堂医药科技有限公司 Traditional Chinese medicine composition for enhancing immunity and mainly treating various chronic difficult and complicated diseases and preparation method thereof

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