CN104258224A

CN104258224A - Schisandra chinensis oral solution for treating lung-and-kidney yin-deficiency type chronic bronchitis and preparation method thereof

Info

Publication number: CN104258224A
Application number: CN201410453420.5A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2014-09-05
Filing date: 2014-09-05
Publication date: 2015-01-07

Abstract

The invention discloses a schisandra chinensis oral solution for treating lung-and-kidney yin-deficiency type chronic bronchitis and a preparation method of the schisandra chinensis oral solution. The schisandra chinensis oral solution comprises bulk drugs in parts by weight: 10-50 parts of schisandra chinensis, 10-20 parts of fresh rehmannia, 10-20 parts of siberian solomonseal rhizome, 10-20 parts of dwarf lilyturf tuber, 10-20 parts of indian buead, 10-20 parts of human placenta, 10-20 parts of lily, 10-20 parts of radix adenophorae, 10-20 parts of common macrocarpium fruits, 10-20 parts of fragrant solomonseal rhizomes, 10-20 parts of mongolian snakegourd roots, 10-20 parts of motherwort herbs, 10-20 parts of white mulberry root-barks, 10-20 parts of tatarian aster roots, 10-20 parts of cochinchnese asparagus roots, 10-20 parts of common anemarrhena rhizomes and 10-20 parts of sessile stemona roots. Schisandra chinensis is used as a main material, and some Chinese traditional medicines with a function of nourishing the liver and kidney and mild flavor are added into the main material, so that the taste is obviously improved; aiming at the defects of bitter smell, poor taste and inconvenient application of the traditional Chinese medicines, the schisandra chinensis oral solution makes great progress and has good market prospect; when the medicines are combined with one another, the functions of tonifying the lung, nourishing the kidney, restraining the lung qi and relieving cough and asthma are achieved, so that the mutual support of the traditional Chinese medicines; therefore, the satisfactory curative effect is realized; the curative effect on simple lung-and-kidney yin-deficiency syndrome type chronic bronchitis is superior to the pure western medicine treatment effect, and the obvious adverse reaction is avoided.

Description

A kind ofly treat shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis and preparation method thereof

Technical field

The present invention relates to the medical health product containing deriving from plant, animal or raw mineral materials, particularly a kind ofly treating shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis and preparation method thereof.

Background technology

Chronic bronchitis patient Relapse rate, the course of disease is long, is commonly encountered diseases and the frequently-occurring disease of respiratory system.The traditional Chinese medical science thinks lung governing qi, kidney improving inspiration by invigorating kidney-QI, and the respiratory function of lung needs the improving inspiration by invigorating kidney-QI of kidney to be used for assisting, therefore has saying of " the lung being the dominator of QI, the kidney being the root of QI ".Cloudy liquid simultaneously between lung kidney also grows mutually, and kidney yin is that cloudy liquid is basic all over the body, so lung yin virtual loss can undermine kidney yin, otherwise deficiency of the kidney yin also can not lung-yin nourishing.

Long-term cough consumption impairing the lung gas and lung yin, very then undermine kidney yin, occur deficiency of both QI and YIN, lung.Deficiency of the kidney yin.Therefore take supplementing QI and nourishing YIN, the method for tonifying the lung and nourishing the kidney during treatment.The category such as Protracted Course of Chronic Bronchitis many genus traditional Chinese medical science " endogenous cough ", " the syndrome of dyspnea ".The traditional Chinese medical science generally believes that this phase card belongs to lung spleen renal dysfunction, and the gesture of pathogenic factor has been frustrated and remaining heresy is most, and spleen transporting is lacked of proper care, kidney failure in functioning of QI, contains in phlegm-damp, so that cough with asthma protracted course of disease.Chronic bronchitis is many with insufficiency of QI of the lung and kidney, and study carefully its disease basic, lung and kidney are the dirty of Jinsui River, the lung being the dominator of QI, the kidney being the root of QI, chronic cough is wound healing lung not, and illness of the mother organ affecting the child one causes edema due to deficiency of the kidney, for expectorant is drink, upper stain is in lung, and persistent cough, a surname falls to take the photograph and receives mistake department, and touching difficulty of coughing heals.Although lung kidney two disease of ZANG-organs becomes in the majority, insufficiency of the spleen factor should not be ignored, and in old age, soil is not good for, and transporting is unable, and water paddy can not turn to precise and tiny defeated with foster lung qi, and can not descend defeated with nourishing kidney unit, gather on the contrary for expectorant is turbid, above store in lung, obstruction of lung-QI, then superinverse is for coughing.Therefore, deficiency of both the lung and kidney, the turbid interior life of expectorant are chronic bronchitis lag phase main pathogenesis.

YIN-deficiency of the lung and kidney refers to because of exopathogen invading the interior heat-transformation impairment of YIN, or internal injury is breathed heavily and coughed, and endlessly, cloudy liquid is impaired, or sexual strain for chronic cough, and feelings will is unsuccessful, and cloudy liquid internal injury etc. all can cause syndrome of yin deficiency of lung and kidney.Syndrome of yin deficiency of lung and kidney can first by lack of lung-YIN, by lung and kidney gradually to YIN-deficiency of the lung and kidney person, has kidney yin first to hinder, is caused YIN-deficiency of the lung and kidney person by kidney and lung, also have Exogenous and internal injuries to damage the cloudy person of lung kidney simultaneously.YIN-deficiency of the lung and kidney prompting lung kidney YIN-fluid being insufficient, dysfunction, main inner feelings is now the clear respectful dereliction of dutys of lungs, and kidney nourishes whole body and haves no right, and disturbance of deficiency-heat inside the body, visceral dysfunction.The traditional Chinese medical science releases name: cough, asthma, the syndrome of dyspnea, pulmonary distension, pulmonary tuberculosis, and asthenia, quenches one's thirst; Doctor trained in Western medicine releases name: chronic bronchitis, bronchial asthma, pulmonary tuberculosis, emphysema, chronic pulmonary heart disease, diabetes, diabetes insipidus, pulmonary carcinoma.

Lung kidney yin liquid nourishes mutually, has the title of " mutual generation between metal and water ".On by lack of lung-YIN, deficiency-heat are disturbed, clear respectful dereliction of duty, therefore cough expectorant is few, and deficiency-heat is burnt lung network then sputum mixed with blood.Lower to deficiency of kidney-YIN, muscles and bones is lost and is supported and soreness of the waist and knees in moistening.YIN-deficiency of the lung and kidney, body fluid cannot flow upwards therefore dryness of the mouth and throat, asthenic fire is burnt vocal cords and hoarseness, fumigation throat and pharyngalgia.Muscle loses day by day becomes thin in moistening foster event body.Cloudy liquid is short, and asthenic fire is rising, hectic fever due to YIN-deficiency tide ' heat.Yin asthenia generating intrinsic heat, flaming up of the ministerial fire then flushed cheeks, inside forcing battalion cloudy is night sweat.If smart room disturbed by fire, pass out semen, deficiency of YIN-blood and infrequent menstruation, asthenic fire undermines yin collaterals then metrorrhagia.The few tongue of red tongue, thready and rapid pulse is all resembling of yin asthenia generating intrinsic heat.

Syndrome of yin deficiency of lung and kidney also can develop into general yin deficiency syndrome, also can be converted into deficiency of kidney-essence card.If deficiency of YIN affecting YANG, can change deficiency syndrome of both YIN and YANG into, clinical manifestation has two: insufficiency of QI of the lung and kidney.Lung controlling breathing is the mark of gas, and kidney governing inspiration is the root of gas.Insufficiency of QI of the lung and kidney is then shown in dyspnea and shortness of breath, the easy antiperspirant of spontaneous perspiration, coldness of the body with chills, or the disease such as cough with copious phlegm.Be common in chronic bronchitis, the illness such as emphysema.YIN-deficiency of the lung and kidney.Have because the deficiency of the lung can not defeated Tianjin nourishing kidney; Have because of suffer from a deficiency of the kidney cloudy essence can not on to hold or asthenic fire is burnt lung.Often present the universe to cough, lose heart, the throat universe is dry, waist soreness, osteopyrexia and fever, the symptoms such as seminal emission night sweat.

In the angle of the traditional Chinese medical science, Fructus Schisandrae Chinensis is often used to nourishing kidney and promotes the production of body fluid, and helps treatment night sweat, excessive thirst and pollakiuria problem, and also helpful in treatment urinary incontinence and premature ejaculation.Fructus Schisandrae Chinensis can protect human five internal organs-heart, liver, spleen, lung, kidney.Before more than 2,000 years, what Royal Palace noble and Chinese medicine master generally adopted this tradition to continue to use keep fit quality goods.

Fructus Schisandrae Chinensis, as the term suggests be a kind of fruit with pungent, sweet, sour, bitter, salty five kinds of property of medicine, general only with one, in the middle of the Chinese crude drug of two kind of flavour of a drug, it is unique to belong in fact.The fruit of this bittersweet, mutual generation of five phases, can to human five internal organs: the heart, liver, spleen, lung and kidney play balanced action.

Fructus Schisandrae Chinensis contains abundant organic acid, vitamin, flavonoid, phytosterol and has the lignan of potent reactivation (such as schisandrin, schisandrin B or Fructus Schisandrae Chinensis fat element), it is also one of the minority medical material having essence, gas, god's three large tonifications concurrently, can the strong liver of QI invigorating, the efficiency of promoting cells exclude refuse, supply more oxygen, construction and utilization energy, raising memory and property endurance.Astringe the lung, nourishing kidney, promotes the production of body fluid, and receives antiperspirant, arresting seminal emission.Fructus Schisandrae Chinensis cures mainly the deficiency of the lung and breathes with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, and impairment caused by overstrain is won thin, emission, chronic diarrhea chronic dysentery.Astringing lung-QI and relieving cough: the void for deficiency of both the lung and kidney is coughed, panted, normal and kidney-reinforcing drug share." herbal classic " carries it: main QI invigorating, cough with dyspnea, impairment caused by overstrain win degree, tonifying for the deficiency, reinforcing YIN-essence.

Fructus Schisandrae Chinensis fruit implementation Chinese medicine function supplementing QI for promoting the production of body fluid, nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, to calm the nerves, chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, disease such as seminal emission chronic diarrhea, forgetful insomnia etc. can be controlled.Pharmacological testing proves excitement and the process of inhibition that can regulate central nervous system, promotes body metabolism, regulates gastric juice and bile secretion, has reducing effect to hepatitis convalescent period transaminase rising person.Peel and ripe seed coat, containing lignanoid, are the effective medicinal components of Fructus Schisandrae Chinensis, comprising multiple schizandrin.

TCM identification is, Fructus Schisandrae Chinensis acid temperature is nontoxic." herbal classic " proposes these product the effects such as QI invigorating tonify deficiency reinforcing YIN-essence.Successive dynasties document describes Fructus Schisandrae Chinensis tonify deficiency labor, strengthening bone and muscle, special tonifying the lung kidney, tonifying five ZANG-organs of holding concurrently, supplementing QI for promoting the production of body fluid.The cough with asthma of damage of suffering from a deficiency of the kidney to values for pulmonary, frequent micturition of quenching one's thirst, spontaneous sweating due to deficiency of QI, night sweat due to yin deficiency, all has therapeutical effect.To improve deficiency of heart-blood, insufficiency of heart-QI, disarmony between the heart and kidney insomnia cardiopalmus all have good action.Therefore be usually used in: lung is suffered from a deficiency of the kidney the cough with asthma of damage, breathes hard, spontaneous perspiration, night sweat, and Tianjin wound is thirsty, quenches one's thirst, deficiency of YIN xerostomia, the card of suffering from a deficiency of the kidney, have a guilty conscience, severe palpitation, forgetful insomnia.

Fructus Schisandrae Chinensis is used for antitussive, eliminates the phlegm, treats the insomnia of body void.For old people's slow down aging etc., therefore for treating the active drug of senile disease.In a word, these product can improve muscle power, and allaying tiredness improves intelligence and increases work efficiency.Kidney essense is gradually empty with increasing age for old people, and muscle power declines day, amnesia, and Fructus Schisandrae Chinensis the kidney invigorating essence is improved mental, therefore can Fructus Alpiniae Oxyphyllae keep fit, and experimentation shows that Fructus Schisandrae Chinensis has certain anti-aging effects in genitourinary system.Therefore, Fructus Schisandrae Chinensis is useful to slow down aging simply and can treats the active drug of some senile disease.

Chinese medicine odor is poor, and mouthfeel is not good; A lot of people is reluctant to take; Also resisting psychology is produced when allowing people use.How the efficacy exertion of Fructus Schisandrae Chinensis not being injured human body again to maximum, and obviously improve mouthfeel, people can be accepted, is our problem in the urgent need to address.Containing the composition for the treatment of YIN-deficiency of the lung and kidney in a large number safely and effectively inside Fructus Schisandrae Chinensis, Chinese herb on the prevention YIN-deficiency of the lung and kidney chronic bronchitis has advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.

Summary of the invention

Technical problem to be solved by this invention is, Chinese medicine odor is poor, and mouthfeel is not good; A lot of people is reluctant to take; Also resisting psychology is produced when allowing people use.In view of the traditional Chinese medical science has the characteristic of dialectical treatmert, the advantage that Chinese medicine toxic side effect is little, Chinese medicine health-care treatment causes extensive concern.Fructus Schisandrae Chinensis cures mainly the deficiency of the lung and breathes with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, and impairment caused by overstrain is won thin, emission, chronic diarrhea chronic dysentery.Astringing lung-QI and relieving cough: the void for deficiency of both the lung and kidney is coughed, panted, normal and kidney-reinforcing drug share." herbal classic " carries it: main QI invigorating, cough with dyspnea, impairment caused by overstrain win degree, tonifying for the deficiency, reinforcing YIN-essence.TCM identification is, Fructus Schisandrae Chinensis acid temperature is nontoxic.Fructus Schisandrae Chinensis treatment lung is suffered from a deficiency of the kidney the cough with asthma of damages, breathes hard, spontaneous perspiration, night sweat, and Tianjin wound yearningly, is quenched one's thirst, deficiency of YIN xerostomia, the card of suffering from a deficiency of the kidney.Have a guilty conscience, severe palpitation, forgetful insomnia.The present invention is major ingredient with Fructus Schisandrae Chinensis, adds some nourishing the liver and kidney, and the Chinese medicine that nature and flavor are gentle obviously improves mouthfeel, and poor for Chinese medicine odor, mouthfeel is not good, uses inconvenience, makes very large this and is apt to, have very strong market prospect; All medicines share tonifying the lung gold, kidney nourishing water, gas of astringing the lung, cough-relieving are breathed heavily, and bring out the best in each other, therefore obtain satisfactory effect.

For solving the problems of the technologies described above, the invention provides a kind of shizandra oral liquid for the treatment of YIN-deficiency type of the lung and kidney chronic bronchitis, the parts by weight of described oral liquid crude drug are: Fructus Schisandrae Chinensis 10 ~ 50 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygonati 10 ~ 20 parts, Radix Ophiopogonis 10 ~ 20 parts, 10 ~ 20 parts, Poria, Placenta Hominis 10 ~ 20 parts, Bulbus Lilii 10 ~ 20 parts, Radix Adenophorae (Radix Glehniae) 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Rhizoma Polygonati Odorati 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Cortex Mori 10 ~ 20 parts, Radix Asteris 10 ~ 20 parts, Radix Asparagi 10 ~ 20 parts, the Rhizoma Anemarrhenae 10 ~ 20 parts, the Radix Stemonae 10 ~ 20 parts.

The shizandra oral liquid of described treatment YIN-deficiency type of the lung and kidney chronic bronchitis, the parts by weight of oral liquid crude drug described in it can be: Fructus Schisandrae Chinensis 10 ~ 30 parts, 10 ~ 15 parts, the Radix Rehmanniae, Rhizoma Polygonati 10 ~ 15 parts, Radix Ophiopogonis 10 ~ 15 parts, 10 ~ 15 parts, Poria, Placenta Hominis 10 ~ 15 parts, Bulbus Lilii 10 ~ 15 parts, Radix Adenophorae (Radix Glehniae) 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Rhizoma Polygonati Odorati 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Cortex Mori 10 ~ 20 parts, Radix Asteris 10 ~ 20 parts, Radix Asparagi 10 ~ 20 parts, the Rhizoma Anemarrhenae 10 ~ 20 parts, the Radix Stemonae 10 ~ 20 parts.

The shizandra oral liquid of described treatment YIN-deficiency type of the lung and kidney chronic bronchitis, the parts by weight of oral liquid crude drug described in it can also be: Fructus Schisandrae Chinensis 10 ~ 40 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygonati 10 ~ 20 parts, Radix Ophiopogonis 10 ~ 20 parts, 10 ~ 20 parts, Poria, Placenta Hominis 10 ~ 20 parts, Bulbus Lilii 10 ~ 20 parts, Radix Adenophorae (Radix Glehniae) 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Rhizoma Polygonati Odorati 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Cortex Mori 10 ~ 15 parts, Radix Asteris 10 ~ 15 parts, Radix Asparagi 10 ~ 15 parts, the Rhizoma Anemarrhenae 10 ~ 15 parts, the Radix Stemonae 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis, it is characterized in that, the preparation process of described oral liquid comprises:

A. the preparation of Fructus Schisandrae Chinensis, as component 1;

B. all the other crude drug described are put into ethanol heating and refluxing extraction 2 times, as component 2;

C. by above-mentioned two kinds of extracting solution components 1 and component also 2-in-1, add dextrin after concentrated and be in harmonious proportion, after disinfection, be prepared into health oral liquor.

In described step a, can Maturity be chosen high, without insect pest, without rotting, the fruit of Fructus Schisandrae Chinensis of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Well sifted ash bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried.

In described step a, may further include, the Fructus Schisandrae Chinensis that dry in the sun is good is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.

In described step b, the medicine of all the other crude drug can be put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then puts into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 80 DEG C 1.36 extractum, become component 2.

In described step c, can by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method for the treatment of the shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis, and its preparation process can also be:

A. the preparation of Fructus Schisandrae Chinensis, as component 1;

B. all the other crude drug described soaked, extract 3 times as component 2;

C. component 1 and component 2 are mixed, add proper honey after concentrated and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

In described step b, all the other crude drug can be soaked in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge lixiviating solution, being condensed into pasty state becomes component 2.

The present invention organically combines theoretical for modern nutriology with Chinese Traditional Medicine health care theory, and in view of the traditional Chinese medical science has the characteristic of dialectical treatmert, the advantage that Chinese medicine toxic side effect is little, Chinese medicine health-care treatment causes extensive concern.Fructus Schisandrae Chinensis cures mainly the deficiency of the lung and breathes with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, and impairment caused by overstrain is won thin, emission, chronic diarrhea chronic dysentery.Astringing lung-QI and relieving cough: the void for deficiency of both the lung and kidney is coughed, panted, normal and kidney-reinforcing drug share." herbal classic " carries it: main QI invigorating, cough with dyspnea, impairment caused by overstrain win degree, tonifying for the deficiency, reinforcing YIN-essence.TCM identification is, Fructus Schisandrae Chinensis acid temperature is nontoxic.Fructus Schisandrae Chinensis treatment lung is suffered from a deficiency of the kidney the cough with asthma of damages, breathes hard, spontaneous perspiration, night sweat, and Tianjin wound yearningly, is quenched one's thirst, deficiency of YIN xerostomia, the card of suffering from a deficiency of the kidney.Have a guilty conscience, severe palpitation, forgetful insomnia.The present invention is major ingredient with Fructus Schisandrae Chinensis, adds some nourishing the liver and kidney, and the Chinese medicine that nature and flavor are gentle obviously improves mouthfeel, and poor for Chinese medicine odor, mouthfeel is not good, uses inconvenience, makes very large this and is apt to, have very strong market prospect; All medicines share tonifying the lung gold, kidney nourishing water, gas of astringing the lung, cough-relieving are breathed heavily, and bring out the best in each other, therefore obtain satisfactory effect; Simple western medical treatment is better than, without obvious adverse reaction to the chronic bronchitis of pure syndrome of yin deficiency of lung and kidney is evident in efficacy.

Detailed description of the invention

Lung kidney is mother child relation, and two disease of ZANG-organs reasons influence each other, and a deficiency of five ZANG-organs weak derivable causes another dirty deficiency.There are YIN-deficiency of the lung and kidney and insufficiency of lung-QI, insufficiency of kidney-YANG not.YIN-deficiency of the lung and kidney with cough, night sweat hectic fever, dysphoria with feverish sensation in the chest palms and soles, soreness of the waist and knees, passes out semen as primary symptom; Insufficiency of lung-QI, insufficiency of kidney-YANG are breathed hard with cough, aversion to cold and cold limbs, spontaneous perspiration, sexual impotence, or see that edema is primary symptom.

The deficiency of YIN is many by after calentura or the miscellaneous diseases with the passing of time cloudy liquid of damage, or to make cloudy liquid secretly consume to form cloudy liquid to lose few because overaction of the five emotions intemperate sexual intercourse crosses the product etc. taking warm-dryness syndrome, body loses to make moist and nourishes large soil, simultaneously because the gas phase of the moon sun not processed then sun heat is to partially prosperous and raw interior-heat, therefore show as repeatedly that one deficiency-heat is dry does not moisten the not peaceful syndrome of asthenic fire restlessness.The deficiency of YIN can with the chronic existence simultaneously of the syndrome such as deficiency of vital energy blood deficiency yang deficiency yang hyperactivity damage of essence body fluid virtual loss and pathogenic dryness or reciprocal causation, show as the deficiency of YIN such as patient's deficiency of qi and yin card, deficiency of YIN-blood card, deficiency syndrome of both YIN and YANG, syndrome of hyperactivity of yang due to yin deficiency, cloudy damage of essence deficiency syndrome, cloudy Tianjin (liquid) virtual loss card, deficiency of YIN syndrome of endogenous dryness, and then can yang deficiency be developed into, the exhaustion of YIN deficiency of YIN can cause the pathological changes such as wind symptom qi depression to blood stasis water retention.

The traditional Chinese medical science think suffer from a deficiency of the kidney disease have deficiency of YIN yang deficiency point, the kidney invigorating should for the difference of kidney yin kidney yang attend school adopt suit the medicine to the illness correlation method carry out theory.The symptom clinical manifestation of deficiency of lung-YIN: dry cough without phlegm or expectorant few and sticky, or sputum mixed with blood, or hoarseness, Yao Xi Acid is soft, and man passes out semen, woman's Hypomenorrhea or amenorrhea or metrorrhagia, emaciated physique; Dryness of the mouth and throat, hectic fever, dysphoria with feverish sensation in the chest palms and soles, night sweat, the few tongue of red tongue or no fur, thready and rapid pulse.

Deficiency of lung-YIN and deficiency of the kidney yin are simultaneously and see it is that assertive evidence examines card basis.Assertive evidence has pneumonopathy generally to see disease, as cough, and expectorant blood; There is the general performance of suffering from a deficiency of the kidney, as soreness of the waist and knees; Also have deficiency-heat syndrome, as parched throat, xerostomia, flushed cheeks, or dysphoria with feverish sensation in the chest palms and soles, the diseases such as osteopyrexia and fever can be decided to be assertive evidence.

The deficiency of YIN is many because of blood deficiency, " the raw interior-heat of the deficiency of YIN ", and show as dysphoria with feverish sensation in the chest palms and soles, dry mouth and throat, god is tired rough, yellowish urine dry stool etc.; Body constitution void declines, shortness of breath and palpitation, dizziness and blurred vision, the mental status are poor; Menoxenia, lusterless complexion, melanin pigmentation, chloasma, butterfly spot grow; Climacteric is perplexed; Enter into the climacteric period too early; Generally be more common in Ms, various superfunction disease as pulmonary tuberculosis, long-term low grade fever etc.The people of the deficiency of YIN should eat of the food of nourishing kidney yin more, take nourishing YIN for suppressing the hyperactive YANG as method.The food of normal selection, as Semen Sesami, Oryza glutinosa, Semen phaseoli radiati, Rhizoma Nelumbinis, Herba Kalimeridis, Chinese cabbage, Auricularia, Tremella, bean curd, Caulis Sacchari sinensis, pears, Citrullus vulgaris, Fructus Cucumidis sativi, Bulbus Lilii, Rhizoma Dioscoreae, sepiellae seu sepiae, Trionyx sinensis Wiegmann, Stichopus japonicus, Carnis Haliotidis, Eriocheir sinensis, milk, Concha Ostreae, Carnis Mactrae, Rhopilema esculenta, duck meat, Corii Sus domestica etc.These food nature and flavor are how sweet cold cool, have effect of the cloudy gas of nourishing body.Nourishing YIN medicated diet can be suitably coordinated to take good care of targetedly.The people of hyperactivity of fire caused by deficiency of YIN, should eat pungent thing less, chaffy dish is preferably eaten less, and Carnis Gallus domesticus is not eaten more yet, and steam, fried, quick-fried, barbi also should eat less, in fruit, Arillus Longan, Fructus Litchi can not be eaten and just not eat.The deficiency of YIN is that only without diet cold drink, cold drink has Accommodation to the deficiency of YIN, certainly, encourages to eat but can not mistake more.

" Bencao Jingshu ": the main QI invigorating person of Fructus Schisandrae Chinensis, all gas of lung master, acid can be received, and just entering lung tonifying the lung, therefore QI invigorating also.Its main cough with dyspnea person, the deficiency of vital energy is then above stopped up and is not returned unit, sour flavor having the property of astringing, takes the photograph gas and returns unit, then cough with dyspnea is from removing.Impairment caused by overstrain is won thin, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence." not Lu " supports the five internal organs, heat extraction, flesh person in raw the moon, the special the kidney invigorating of Fructus Schisandrae Chinensis, tonifying five ZANG-organs of holding concurrently, kidney storing essence, and essence is contained then cloudy strong, and receive and take the photograph, vital qi returns unit, and public region is warmed up, digesting food, steams waste matter and changes precise and tiny, then smart spontaneous, and essence is raw then cloudy long, therefore main as above all diseases also." book on Chinese herbal medicine converges and says ": Fructus Schisandrae Chinensis, the medicine that astringing QI promotes the production of body fluid also.Therefore the gas of Tang Materia Medica main convergence deficiency of the lung chronic cough dissipation.All deficiency of vital energy dyspnea with rapid respiration, cough with dyspnea strains, and spirit is not enough, and arteries and veins gesture is hollow, or impairment caused by overstrain yang-energy, limbs are won thin, or empty gas is superior, and spontaneous perspiration comes frequently, or essence unit exhausts, deficiency of YIN fire is scorching, or exhaustion of YIN YANG-depletion, refreshing scattered pulse takes off, and control it with Fructus Schisandrae Chinensis, salty holding back with its acid is promoted the production of body fluid, and protects reinforcing premodial qi and without spermatorrhea also.So upper enter lung, under enter kidney, enter the benefit that lung has Jiyuan of promoting the production of body fluid, entering kidney has controlling nocturnal emission with astringent drugs to support the merit of marrow." medicineization justice ": Fructus Schisandrae Chinensis, the five tastes are salty standby, and acid solely victory, lung qi can be restrained, cure mainly asthenia chronic cough.Lid lung libido is received, if chronic cough, the burnt leaf of lung is lifted, body fluid being unable to be produced, asthenia then lung because of gas weary, excessive thirst is more than, holds back it with this, moistens it, then its dirty property, and make cough peaceful, spirit is from prosperous.But cough and can not suddenly not use for a long time, probably lung-fire is strongly fragrant holds back, pathogen beam cut-off, must be clear to the loose fire of blood, the receipts merit ear of use." book on Chinese herbal medicine asks former ": Fructus Schisandrae Chinensis is cough key medicine, all cough due to wind and cold, cough due to summer-heat affection, the cough due to dryness, epersalgia cough, and kidney water void is coughed, and kidney fire void is coughed, and chronic cough dyspnea with rapid and short breath, floating and deficient pulse, weak pulse being felt like the leave of Chinese onion person, the sky and water are not handed over yet, all use it.Early, probably its getter is too rapid, does not know Zhong Jing typhoid fever cough with asthma for the suspicious diseases caused by exogenous pathogenic factor of the sage of the past, and XIAOQINGLONG TANG, also with it, so must be closed Herba Asari, Rhizoma Zingiberis sends out wind and cold to rise, and with this to hold back it, then lifting spirit and cough are from only, singly get the five tastes to control cough person from without house Rhizoma Zingiberis.

In the angle of the traditional Chinese medical science, Fructus Schisandrae Chinensis is often used to nourishing kidney and promotes the production of body fluid, and helps treatment night sweat, excessive thirst and pollakiuria problem, and also helpful in treatment urinary incontinence and premature ejaculation.Fructus Schisandrae Chinensis can protect human five internal organs-heart, liver, spleen, lung, kidney at China and modern japan (stealing a large amount of Chinese medicine data during aggression against China), and Fructus Schisandrae Chinensis is popular monograph subject matter.Before more than 2,000 years, what Royal Palace noble and Chinese medicine master generally adopted this tradition to continue to use keep fit quality goods.Fructus Schisandrae Chinensis, as the term suggests be a kind of fruit with pungent, sweet, sour, bitter, salty five kinds of property of medicine, general only with one, in the middle of the Chinese crude drug of two kind of flavour of a drug, it is unique to belong in fact.The fruit of this bittersweet, mutual generation of five phases, can to human five internal organs: the heart, liver, spleen, lung and kidney play balanced action.

Fructus Schisandrae Chinensis contains abundant organic acid, vitamin, flavonoid, phytosterol and has the lignan of potent reactivation (such as schisandrin, schisandrin B or Fructus Schisandrae Chinensis fat element), it is also one of the minority medical material having essence, gas, god's three large tonifications concurrently, can the strong liver of QI invigorating, the efficiency of promoting cells exclude refuse, supply more oxygen, construction and utilization energy, raising memory and property endurance.In ancient times, Russian hunter must take Fructus Schisandrae Chinensis to keep fit QI invigorating at every turn before going on a long journey hunting.

Fructus Schisandrae Chinensis has outstanding effect, comprising: 1, protect the liver and regenerate liver organization.Liver is the maincenter removing toxic substances organ of human body, is responsible for filtering noxious substance, in order to avoid damage human body.Fructus Schisandrae Chinensis has antiinflammation, Fructus Schisandrae Chinensis has antiinflammation, to prevent hepar damnification, activates anabolic process to promote the reparation of wounded hepatocytes, and the activity of DNA (DNA) synthetic and ornithine decarboxylase can be strengthened, regeneration liver cell.Carbon tetrachloride (CCl4) be wherein a kind of to liver most poison material.Countless research displays, the potent liver-protecting efficacy of Fructus Schisandrae Chinensis can resist the toxic action of CCl4.Fructus Schisandrae Chinensis has very large effect at the liver protecting from daily toxin infringement as can be seen here!

2, protection and strengthen heart body: Fructus Schisandrae Chinensis is conducive to histiocytic oxygen exchange, and in the case of some anoxias and myocardial damage, has obtained confirmation and can produce protective effect to heart tissue.It also can palmic rate and relieve hypertension gently.

3, intelligence is promoted sound: Fructus Schisandrae Chinensis can activate nervous system, promote respond, mental concentration and coordinative role, and it is clear to strengthen thinking.Although it has the effect of activation, there is no caffeine side effect restless.This slight berry, is also used to treat melancholia sometimes, and helps improvement agitation and forgetful problem.Strengthen device endurance.Fructus Schisandrae Chinensis energy stamina intensifying and strength also accelerate antisecosis.In Russia, show with the result of study that Plant personnel and child are subjects, Fructus Schisandrae Chinensis can promote endurance, physical strength reinforcing and minimizing disease.

4, anti-anti-free radical infringement: free radical causes the hypodynamic main cause of atherosclerosis, cancer, coronary heart disease and immunity, is also the arch-criminal causing ageing process to accelerate.Lignan contained by Fructus Schisandrae Chinensis is potent antioxidants, can suppress free radical, and can increase the level of the antioxidant-glutathion in liver.

5, delay the aging process: research report shows, and Fructus Schisandrae Chinensis is often used as the tonic of aging resistance and QI invigorating, and result of study more illustrates this principle.Research finds, the lignan contained by Fructus Schisandrae Chinensis can strengthen the energy production of adenosine triphyosphate (ATP) or mitochondrion (cellular energy storehouse), protects grain line body to encroach on from oxidative pressure simultaneously.These effects are enough to illustrate that why Fructus Schisandrae Chinensis can slow down ageing process and delay to occur ageing-related disease, as heart failure, Alzheimer disease and Parkinson's disease.

Fruit of Fructus Schisandrae Chinensis unique flavor, there are honey flavour and delicate fragrance, its vegetal pole is enriched, in sugary reducing sugar such as (mainly) fructose, citric acid, malic acid, tannin, vitamin, more than 20 seed amino acids, 18 kinds of mineral elements and the composition such as resin, Saponin, especially with vitamin C and content of reducing sugar higher.According to surveying and determination, every 100g fresh schisandra chinensis sarcocarp is containing vitamin C 1009mg, and content is only second to Fructus Rosae Normalis, is 2 times of fresh Fructus Jujubae, 10 times of Fructus actinidiae chinensis, 30 times of mandarin orange.Secondly, Fructus Schisandrae Chinensis contains abundant zinc and selenium, and these two kinds of elements are the trace element with specific health care and anti-cancer efficacy of needed by human.

Modern pharmacology proves: fruit of Fructus Schisandrae Chinensis is oral can promote that gastric secretion helps digest, and intestinal mucosa can be made again to shrink, and secretion reduces and antidiarrheal; Fructus Schisandrae Chinensis decocting liquid all has stronger inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, dysentery bacterium and influenza virus.1, controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.Containing a large amount of acidic materials, soap one-tenth etc. in Fructus Schisandrae Chinensis, can pass out semen lingering diarrhea, woman's leukorrhagia of man be prevented too much in controlling nocturnal emission with astringent drugs room, again can astringing intestine to stop diarrhea road, prevent the ineffective caused dysentery of insufficiency of the spleen constraint.2, reducing urination for preventing enuresis.Containing a large amount of acidic materials and Saponin in Fructus Schisandrae Chinensis, there is restriction wing and take off sphincter, extend interval between micturition, increase each effect of discharging urine volume, can be used for the disease for the treatment of the enuresis and frequent micturition.3, relieving cough and asthma, spasmolytic.The traditional Chinese medical science is thought, breath with cough and how to be caused by abnormal rising of lung-QI, Fructus Schisandrae Chinensis sour-puckery flavor, gas of astringing the lung, can relieving cough and asthma.Modern study finds, the composition containing anti-smooth muscle spasm in Fructus Schisandrae Chinensis, can prevent the spasm of gastrointestinal and trachea.4, alcoholic liver is prevented.Economize alcohol, hot-tempered matter and soap formula etc. containing fatty acid, Bu Gu in Fructus Schisandrae Chinensis, blood fat can be reduced, reduce fat in endovascular deposition, can be used for treating atherosclerosis.5, anti-inflammation.Research finds, Fructus Schisandrae Chinensis extractive solution can kill staphylococcus aureus and escherichia coli etc., can be used to treat the disease caused because of S. aureus L-forms or coli-infection.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Fructus Corni, cure mainly pathogen cold and heat under the heart, warming middle-JIAO, by cold temperature numbness, goes three worms, for a long time clothes made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stop the merit of dribbling urination; Take improving eyesight, brute force for a long time all the year round.Fructus Corni, have another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., for China commonly uses rare Chinese medicine, applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Zhang Zhongjing is that monarch has formulated " JINGUI SHENQI WAN " with Fructus Corni.According to chemical analysis, Fructus Corni contains the effective ingredient such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibacterial, is the Herba indigoferae Pseudotinctoriae commonly used in tcm clinical practice.

The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; The effect of Radix Rehmanniae and Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, is often for consumption of YIN caused by febrile disease, the diseases such as haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.Relative to Radix Rehmanniae, Radix Rehmanniae is heat clearing and blood cooling, also can promote the production of body fluid, all right yin nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sends out the problems such as speckle dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, menoxenia, frequent fetal movement, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat epidemic febrile disease, qingying decoction can be done with the Radix Rehmanniae; If the later stage for the treatment of epidemic febrile disease, because waste heat does not also disappear to the greatest extent, the Radix Rehmanniae should be used for boiling QINGHAOBIEJIATANG; In addition, contain for heat in blood poison, macule purple is black, and the serious heat of epidemic febrile disease enters the symptom of nutrient blood, can take the Sisheng Wan that the Radix Rehmanniae is made; General want YIN nourishing and the production of body fluid promoting to treat interior-heat quenches one's thirst with constipation, the once liquid soup that the Radix Rehmanniae boils should be eaten.

Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, and be clearing away heat-fire class medicine, its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, and evacuation of pus is subsided a swelling.Cure mainly: control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.For treatment diabetes, conventional it and drugs for nourishing yin with the use of, to reach the effect for the treatment of both the principal and secondary aspects of a disease." book on Chinese herbal medicine converge with speech ": Radix Trichosanthis, it is hot and suffocating to move back the five internal organs, and as heart-fire is contained and dry tongue and mouth, lung-fire is contained and pharyngeal swelling sore throat, and spleen-fire is contained and dispute tooth swells, and phlegm-fire is contained and cough is not peaceful.If the side of body of liver-fire is swollen migratory arthralgia caused by wind, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle is not burst, and pyretic toxicity does not fall apart, or five types of jaundice yellow skin and eye, and if if little water drenches puckery, be caused by all burning hot pent-up, phlegm-fire, falls in only this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control thirsty, and control empty thirsty from tonic, control fire from the medicine of a cold nature thirsty, control yearningly strongly fragrant from gas medicine, controlling excessive thirst from blood medicine, is control thirsty key medicine also.

Rhizoma Polygonati: Rhizoma Polygonati is used as medicine with rhizome.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat such as to be quenched one's thirst the disease.Very effective in cure for diabetes.Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, blood fat reducing, atherosclerosis, and slow down aging and the effect such as antibacterial, polygonatum polysaccharide has Immunestimulatory effect.For lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough etc. of YIN-deficiency of the lung and kidney.For weakness of the spleen and stomach.Both tonifying spleen-yin, again strengthening the spleen gas, obtain dizzy, soreness of the waist and knees for deficiency of kidney essence, early whitening of beard and hair and quenching one's thirst.Rhizoma Polygonati strengthening bone and muscle, beneficial marrow, bleaches and sends out; The cough expectorant be suitable for caused by lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.

Radix Ophiopogonis Radix Ophiopogonis nature,taste and action: sweet, micro-hardship, cool, Yin-nourishing and body fluid promoting, nourishing the lung to arrest cough, clear away heart-fire relieving restlessness.Cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry pharynx lung-heat, cough, pulmonary tuberculosis.Join Radix Adenophorae (Radix Glehniae), lung stomach is ruled together, and has the cool stomach of lung heat clearing, the good effectiveness of YIN nourishing and the production of body fluid promoting, for the few expectorant of the dry cough caused by lung-dryness syndrome due to deficiency of YIN or thermal burn lung yin, and the diseases such as dry laryngopharynx.Join Fructus Schisandrae Chinensis, sour and sweet drugs can transforme into YIN, keep the moon so stay sun, sun stays antiperspirant from stopping.Function yin nourishing arresting sweating, with controlling deficiency of YIN hyperhidrosis, cardiopalmus, chronic cough of deficiency lung, few expectorant or expectorant glue not well etc.

Placenta Hominis, has another name called Placenta Hominis, afterbirth etc., is the Placenta Hominis that healthy women is given birth to, and process is cleaned, smoke drying forms.Placenta Hominis begins to be loaded in supplement to the Herbal uploads that " main vim and vigour are won thin, and married woman strains, and the thin skin in face is black, all diseases gradually thin worried person in abdomen." traditional Chinese medical science thinks, Placenta Hominis is warm in nature, sweet-salty, enters lung, kidney channel, and having the function of strongly invigorating QI and blood, beneficial smart the kidney invigorating, is the tonic commonly used simply.With its can control QI and blood deficiency, insufficiency of the spleen lack of appetite, cough due to deficiency of the lung, puerperal hypogalactia, seminal emission sexual impotence, leukorrhagia metrorrhagia, the disease such as infertile of miscarrying.Modern pharmacological research shows, Placenta Hominis contains sex gland hormones, ovarian hormone, Alfasone, several amino acids, placental globulin, fibrin stabilizing factor, urokinase inhibitor, plasminogen activator etc.Third kind of placental globulin has the specific function of enhancing human body immunity power, and interferon has antiviral and anticancer effect.Described in comprehensive, Placenta Hominis has the anti-ageing function of good health-care; Often take it to benefit to human body.

Bulbus Lilii: the traditional Chinese medical science thinks that Bulbus Lilii cold nature is put down, have relieve inflammation or internal heat, lung moistening, the effect of calming the nerves, its flower, squamous stem all can be used as medicine, and is a kind of flowers of dietotherapeutic.Bulbus Lilii, except containing except the nutrient such as starch, protein, fat and calcium, phosphorus, ferrum, vitamin B1, B2, C, also contains some special nutritional labelings, as multiple alkaloids such as colchicine.These composition comprehensive functions, in human body, not only have the merit of good nutritious tonifying, but also to dry in autumn and multiple Seasonal diseases that is that cause has certain preventive and therapeutic effect.The traditional Chinese medical science is said fresh Bulbus Lilii has tranquilizing by nourishing the heart, effect of nourishing the lung to arrest cough, weakling is after being ill highly profitable.

Radix Adenophorae: clearing away heat and nourishing YIN, nourishing the lung to arrest cough.Cure mainly tracheitis, pertussis, cough due to lung-heat, cough up phlegm yellow thick.Radix Adenophorae sweet in the mouth, micro-hardship, cold nature.Attach to the lung and stomach meridians.The light gas of body and, rise and edge down.There is removing heat from the lung and dissipating phlegm, nourishing YIN to relieve dryness, effect of reinforcing stomach reg fluid.Cure mainly fever due to yin deficiency, dryness of the lung dry cough, consumptive lung disease consumptive disease is coughed, sputum mixed with blood, sore throat pharyngalgia, and Tianjin wound is thirsty.Radix Adenophorae replenishing YIN and removing heat moistening the lung and resolving phlegm treatment deficiency of YIN chronic cough consumptive disease expectorant blood cough caused by dryness expectorant of coughing is few; Deficiency-heat sore throat (nourishing the lung to arrest cough).Radix Glehniae deficiency of stomach-YIN deficiency of body fluid dry throat and mouth (nourishing the stomach to promote the production of body fluid).Radix Adenophorae nourishing the lung to arrest cough: the chronic cough dry cough for deficiency of lung-YIN often joins Bulbus Fritillariae Uninbracteatae Radix Ophiopogonis.

Rhizoma Polygonati Odorati: nourishing YIN and moistening the lung; Nourishing the stomach to promote the production of body fluid.Cough caused by dryness; Chronic cough; The dry throat and mouth of calentura cloudy liquid consumption wound; Interior-heat is quenched one's thirst; Deficiency of YIN diseases caused by exogenous pathogenic factor; Dizzy dizzy; Muscle arteries and veins spasm and pain.Rhizoma Polygonati Odorati sweet in the mouth greasiness, matter is soft and moisten, and is the good medicine of YIN nourishing and the production of body fluid promoting simply.Vitamin A contained in Rhizoma Polygonati Odorati, improves dry and cracked, rough skin situation, makes it soft lubrication.Play the effect of beauty and skin care." stem is tetanic, like bamboo arrow shaft, has joint for Collective Notes to the Canon of Materia medica cloud." therefore have the name of Rhizoma Polygonati Odorati.The rhizome of plant can hyoscine, and Chinese medicine name is also Rhizoma Polygonati Odorati, and autumn excavates, and cleans, shines to softness, repeatedly rub, and dry in the sun, to without hard-core, is dried, or steams thoroughly, rubs to translucent, dries, and cuts sheet or section use." book on Chinese herbal medicine justice ": " control lung dryness of the stomach heat, the diseases such as body fluid dries up, thirsty dry sensation in the pharynx, and excessiveness of stomach-fire, dry thirsty rapid digestion of food, polyorexia person, You Youjie is imitated ".

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri, containing the material such as leonurine, Fumaric acid, has the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema.

Cortex Mori is the root bark of moraceae plants Mulberry Morus alba L..Main product in Anhui, Henan, Zhejiang, Jiangsu, the ground such as Hunan.Effect: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria." property of medicine opinion ": make, flat.Can control lung qi dyspnea with fullness of the chest, aqueous vapor edema, main wound is exhausted, dredging water passages, and disappear aqueous vapor, and asthenia exopathogenic heat is had a headache, interior tonifying for the deficiency." Japan hanako materia medica ": temperature, in tune, the therapeutic method to keep the adverse QI flowing downwards.Expectorant is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, and kill abdomen and hide worm, only cholera is vomited and diarrhoea.

Radix Asteris is warm in nature, bitter in the mouth, pungent.Effect and effect: nourishing the lung to keep the adverse QI downward; Preventing phlegm from forming and stopping coughing.Main cough; Deficiency of the lung chronic cough; Consumptive lung disease lung abscess; Cough vomiting bloody pus; Dysuria.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.Be used for the treatment of chronic cough asthma.Radix Asteris has another name called blue or green aster, purple Qian, is the root and rhizome of feverfew Radix Asteris, is born in mountain region or meadow, river bank more, " Bencao Tujing " cloud: " Radix Asteris, the raw Seedling leaf in cloth ground in three days, its leaf three or four is connected, and opens yellow purple and spend in vain in June in May, knot black mole." all can excavate in spring, autumn every year, removing stem and leaf and earth, its fibrous root is weaved into plait, and commodity are called " RADIX ASTERIS ", dry and can be used as medicine.It is warm in nature, bitter in the mouth, enters lung meridian, has effect of the warming the lung therapeutic method to keep the adverse QI flowing downwards, expectorant antitussive, is usually used in treatment cough due to wind and cold asthma, asthenia coughs the diseases such as vomiting bloody pus, sore throat, dysuria, is the medicine of lung gold blood system." medicineization justice ": Radix Asteris, sweet in the mouth and be with hardship, cool in nature and body profit, Qia He pulmonary blood system.Cure mainly the burnt leaf of lung to lift, chronic cough sputum mixed with blood, and consumptive lung disease, phlegm dyspnea, quenches one's thirst, and makes lung key have the merit in refrigerant abundant pool.With entering Liver Channel, all consumptive fever are not enough, and the table disease of liver also; Accumulation of heat stagnation of QI, in liver, disease is also; Hematemesis and epistaxis, liver inverse also upper; To have blood in stool hematuria, liver absurd under also; Invariably prove effective.Because its body moistens, be apt to energy nourishing kidney, lid kidney controlling urination and defecation, moistens constipation due to dry stool with this, and diuresis is short red, exploitation negative and positive, and the logical heap soil or fertilizer over and around the roots of a surname is stagnant, has siddhi greatly.The same Radix Rehmanniae, Radix Ophiopogonis enter the heart, allay excitement and nourish blood.Same Cortex Moutan, Radix Paeoniae Rubra enter stomach, clearing away heat and cooling blood.Its Cortex Mori is gas medicine in lung, and Radix Asteris is blood medicine in lung, should use respectively.

Radix Asparagi has another name called Radix Asparagi.Cold in nature, sweet in the mouth, micro-hardship.There is replenishing YIN and removing heat, effect of lung moistening nourishing kidney.For controlling fever due to yin deficiency, cough haematemesis, lung abscess, laryngopharynx swelling and pain, quench one's thirst, the disease such as constipation.Sweet in the mouth; Bitter; Property Great Cold.Return lung; Kidney channel.Effect qingfei yihuo is nourshing Yin and drynsessmoistening prescription.Tonic; Lung heat clearing medicine.Cure mainly cough caused by dryness-heat; [2] deficiency of YIN chronic cough; Consumption of YIN caused by febrile disease; Interior-heat is quenched one's thirst; Dryness of the intestine constipation; Laryngopharynx swelling and pain [3].Diabetes, constipation due to dry stool; Sore swollen toxin is controlled in external, venom." book on Chinese herbal medicine converges and says ": Radix Asparagi, moisturize YIN nourishing, the medicine of pathogenic fire reducing lung heat clearing also.System reason lung kidney fire is dry is disease, and as the scorehed lung-lobe due to lung-heat, send out as flaccidity carbuncle, cough of spitting blood, excessive thirst passes as diabetes involving the kidney, and hectic fever due to YIN-deficiency Re Laozhu demonstrate,proves, the required person of institute also.Forefathers have meaning except inclined numbness, bone strengthening marrow person, and because lung-heat becomes flaccidity, kidney-heat marrow is withered, and the inclined numbness person of the withered not Rong Ercheng of muscle also.Radix Asparagi the moon profit is cold mends, and dry person is moistened, and hot person is clear, then bone marrow is strong, and inclined numbness can profit.So must should it with first deficiency-heat victor." property of medicine opinion ": main lung qi cough with dyspnea, pant short anxious, heat extraction, leads to kidney qi, treats the raw carbuncle vomiting pus of consumptive lung disease, controls scabies humida, only quench one's thirst, apoplexy of reducing phlegm and internal heat, should take for a long time." prescriptions worth thousand gold ": control asthenia and hinder absolutely, decline old age damage win thin, hemiplegia not with, rheumatism is meciless, cold numbness, and trusted subordinate gathers, malignant boil, and carbuncle swells leprosy, also controls impotence, deafness, order are dark.

The Rhizoma Anemarrhenae is bitter, sweet, cold.Return lung, stomach, kidney channel.Effect clearing away heat-fire, promotes the production of body fluid and moisturizes.Clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.Be used for the treatment of cough due to lung-heat or deficiency of YIN cough caused by dryness, have and let out lung-fire clearly, the effect of nourishing YIN and moistening the lung.Normal and Bulbus Fritillariae Uninbracteatae is same in order to strengthen the merit of clearing away lung-heat and moistening for dryness, as female loose in " collection of prescriptions with notes " two.. for hyperactivity of fire caused by deficiency of YIN, osteopyrexia and fever, night sweat person, has the effect of nourishing YIN to lower pathogenic fire, and normal and Cortex Phellodendri mutual reinforcement between is for use.For fever due to yin deficiency, cough due to consumptive disease and the disease such as to quench one's thirst.Rhizoma Anemarrhenae energy purte the white and nourishing kidney, therefore can not only excess-heat clearly, and can clearind deficient heat.Many and the same use of Cortex Phellodendri, allocates in drugs for nourishing yin, as ZHIBAI DIHUANG WAN, controls the disease such as hyperactivity of fire caused by deficiency of YIN, hectic fever hectic fever due to YIN-deficiency clinically.This product joins nourishing YIN and moistening the lung medicine as product such as Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis, Bulbus Fritillariae Cirrhosae again, can be used for deficiency of the lung cough caused by dryness; Join clearing away heat and promoting production of body fluid medicine as product such as Radix Trichosanthis, Radix Ophiopogonis, RADIX PUERARIAE, available controlling is quenched one's thirst.

The Radix Stemonae is sweet, bitter, tepor.Return lung meridian.Function cures mainly: nourishing the lung to arrest cough; Parasite killing delousing.Main new chronic cough is coughed; Pulmonary tuberculosis; Pertussis; Enterobiasis; Body louse; Tinea scabies.Based on the Radix Stemonae (every agent 6 ~ 8 money), compatibility Radix Glycyrrhizae, Radix Asteris, Semen Ginkgo, Radix Scutellariae, Herba Ephedrae etc., form several different prescription, treatment chronic senile tracheitis 100 example, through the follow-up observation of 1 year, total effective rate was 75%, and wherein preliminary cure rate is 25%, obvious effective rate is 9%, and improvement rate is 41%.Within after taking medicine 1 ~ 2 day, namely feel that cough alleviates, and serve within 10 days and can occur the highest effect.Male and the type patient outcome that pants poor.Minority case has the minor responses such as xerostomia, stomachache, the puffiness of the eyes after taking medicine, and does not affect treatment.In addition, useful Radix Stemonae compatibility equivalent Herba Ephedrae, Semen Armeniacae Amarum, make pill (every ball 2 money) with Mel, and sooner or later respectively taking 2 balls, 10 days is a course for the treatment of.Observe 181 examples summer, after 1 ~ 2 course for the treatment of, effective percentage reaches 88.3% (clinical cure rate 23.1%, obvious effective rate 21%, improvement rate 44.2%).Generally namely saw obvious curative effects at 5 ~ 10 days.

The specific embodiment of the invention

Specific embodiment 1: it is high that autumn chooses Maturity, without insect pest, without rotting, the fruit of Fructus Schisandrae Chinensis of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Well sifted ash bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried.

The Fructus Schisandrae Chinensis that dry in the sun is good is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.

By all the other the crude drug Radix Rehmanniae, Rhizoma Polygonati, Radix Ophiopogonis, Poria, Placenta Hominis, Bulbus Lilii, Radix Adenophorae (Radix Glehniae), Fructus Corni, Rhizoma Polygonati Odorati, Radix Trichosanthis, Herba Leonuri, Cortex Mori, Radix Asteris, Radix Asparagi, the Rhizoma Anemarrhenae, the Radix Stemonae, puts into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then put into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 80 DEG C 1.36 extractum, become component 2.

By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 2: it is high that autumn chooses Maturity, without insect pest, without rotting, the fruit of Fructus Schisandrae Chinensis of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Well sifted ash bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried.Fructus Schisandrae Chinensis 5000g good for dry in the sun is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.By Radix Rehmanniae 1500g, Rhizoma Polygonati 1500g, Radix Ophiopogonis 1500g, Poria 1500g, Placenta Hominis 1500g, Bulbus Lilii 1500g, Radix Adenophorae (Radix Glehniae) 1500g, Fructus Corni 1500g, Rhizoma Polygonati Odorati 1500g, Radix Trichosanthis 1500g, Herba Leonuri 1500g, Cortex Mori 1500g, Radix Asteris 1500g, Radix Asparagi 1500g, Rhizoma Anemarrhenae 1500g, Radix Stemonae 1500g, put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then concentrating under reduced pressure tank is put into, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06 extractum, become component 2.By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 3: it is high that autumn chooses Maturity, without insect pest, without rotting, the fruit of Fructus Schisandrae Chinensis of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Well sifted ash bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried.Fructus Schisandrae Chinensis 4000g good for dry in the sun is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.By Radix Rehmanniae 1200g, Rhizoma Polygonati 1300g, Radix Ophiopogonis 1100g, Poria 1200g, Placenta Hominis 1100g, Bulbus Lilii 1200g, Radix Adenophorae (Radix Glehniae) 1300g, Fructus Corni 1200g, Rhizoma Polygonati Odorati 1200g, Radix Trichosanthis 1300g, Herba Leonuri 1200g, Cortex Mori 1200g, Radix Asteris 1200g, Radix Asparagi 1200g, Rhizoma Anemarrhenae 1300g, Radix Stemonae 1200g, to soak in water 12 hours, then extraction pot heated and boiled is put into 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates are combined, by filtered through gauze, 50-60% ethanol is added in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, be condensed into pasty state by component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 4: it is high that autumn chooses Maturity, without insect pest, without rotting, the fruit of Fructus Schisandrae Chinensis of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Well sifted ash bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried.Fructus Schisandrae Chinensis 3500g good for dry in the sun is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.By Radix Rehmanniae 1100g, Rhizoma Polygonati 1100g, Radix Ophiopogonis 1000g, Poria 1200g, Placenta Hominis 1100g, Bulbus Lilii 1200g, Radix Adenophorae (Radix Glehniae) 1100g, Fructus Corni 1100g, Rhizoma Polygonati Odorati 1000g, Radix Trichosanthis 1100g, Herba Leonuri 1100g, Cortex Mori 1200g, Radix Asteris 1100g, Radix Asparagi 1100g, Rhizoma Anemarrhenae 1200g, Radix Stemonae 1100g, after described crude drug being put into pulverizer pulverizing, particulate matter is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, above-mentioned two kinds of extracting solution are merged, as component 2; When to merge component 1 component 2 concentrating under reduced pressure relative density be 70 DEG C 1.38 filtrate, reclaim ethanol, call in dextrin or Mel, bottle after ultraviolet sterilization.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of white mice, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicated powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD 50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicated powder dosage is > 42g/kg. day (every g medicated powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with matched group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safety range of the present invention is comparatively large, is a kind of safe and reliable health product.

Pharmacodynamic experiment:

Observe the clinical efficacy that the present invention treats simple type syndrome of yin deficiency of lung and kidney chronic bronchitis.Method: 120 routine patients are divided into two groups at random, matched group 40 example gives antiinflammatory, relieving cough and resolving phlegm, the conventional therapies such as spasmolytic suppressing panting calming medicine; Treatment group 80 example adopts the present invention's treatment.Two groups of courses for the treatment of are 4 weeks.1 course for the treatment of terminates rear observation two groups of curative effects.Result: treatment group overall clinical efficacy rate is 92.5%, improving tcm syndrome effective percentage is 91.3%, and matched group overall clinical efficacy rate is 57.5%, and improving tcm syndrome effective percentage is 70.O%.Two groups two are compared, and treatment group is better than matched group (P < 0.05).

Chronic bronchitis belongs to Chinese medicine " cough " or " cough with asthma disease " category, all according to different clinical manifestation determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.The present invention treats simple type syndrome of yin deficiency of lung and kidney chronic bronchitis 80 example and achieves good curative effect, and has carried out paired observation with 40 examples of western medicine routine treatment, existing that report the test is as follows.

1 clinical data

1.1 physical data choose chronic bronchitis patient 120 example of my institute's Integrated TCM & Western Medicine Dept. hospitalization of in June, 2010-December, are divided into treatment group and matched group according to randomly assigne.Treatment group 80 example, man 52 example, female 28 example; Age 47-78 year, average (54.8 ± 3.5) year; The course of disease 1 year-15 years, average (4.6 ± 3.7) year.Matched group 40 example, man 22 example, female 18 example; Age 46-80 year, average (56.6 ± 8.5) year; The course of disease 1 year-17 years, average (5.1 ± 4.1) year.Two groups of patient clinical data comparing difference not statistically significants (P > 0.05), have comparability.

1.2 diagnostic criteria

1.2.1 Western medicine diagnose standard is drafted according in November, 1979 whole nation chronic bronchitis clinical speciality meeting revised standard.(1) to cough, to cough up phlegm for cardinal symptom or with panting.Annual morbidity continues 3 months, and continuous more than 2 years; (2) get rid of pulmonary tuberculosis, pneumoconiosis, pulmonary abscess, bronchial asthma, heart disease, cardiac insufficiency, chronic naso-pharynageal disease etc. there is cough, cough up phlegm, the other diseases of wheezing symptoms.

1.2.2 in accordance with " the clinical guidance principle of new Chinese medicine guideline of clinical investigations new Chinese medicine treatment chronic bronchitis " Chinese and western medicine diagnostic criteria.Syndrome of yin deficiency of lung and kidney: 1. primary symptom: dry cough without phlegm or few expectorant, sputum is sticky not easily to be brought up, and often moves then to breathe hard or accompany and pants; Red tongue, few tongue or the few Tianjin of tongue stripping, thready and rapid pulse.2. secondary disease: dry mouth and throat, dysphoria with feverish sensation in the chest palms and soles, hectic fever night sweat, has a dizzy spell, soreness of the loins and weakness of the limbs.

1.2.3 exclusion standard (1) inspection confirms, the chronic cough caused by factors such as tuberculosis, fungus, tumor, pneumosilicosis, irritative gas, allergy is panted patient; (2) concurrent severe cardiac pulmonary insufficiency person; (3) cardiovascular is merged, kidney, the severe primary such as lung, hemopoietic system disease or psychotic; (4) gestation or women breast-feeding their children; (5) allergic constitution and to multi-medicament allergy sufferers.

2 Therapeutic Method

2.1 matched groups give azithromycin (Hong Kong advanced technology Industrial Co., Ltd), 0.5g/d, relieving cough and resolving phlegm adopts antitussive fast active capsule (Chifeng Tianqi Pharmaceutical Co., Ltd.), 2/d, and spasmolytic such as to be relievingd asthma at the conventional therapy, totally 4 weeks.

2.2 treatment groups adopt oral liquid of the present invention, square medicine composition: Fructus Schisandrae Chinensis 30g, Radix Rehmanniae 12g, Rhizoma Polygonati 11g, Radix Ophiopogonis 12g, Poria 13g, Placenta Hominis 13g, Bulbus Lilii 14g, Radix Adenophorae (Radix Glehniae) 14g, Fructus Corni 13g, Rhizoma Polygonati Odorati 11g, Radix Trichosanthis 12g, Herba Leonuri 13g, Cortex Mori 14g, Radix Asteris 14g, Radix Asparagi 14g, Rhizoma Anemarrhenae 13g, Radix Stemonae 12g, oral liquid is made, sub-service 2 bottles sooner or later, 4 weeks courses for the treatment of by embodiment 2.

3 observation of curative effect

The change of clinical symptoms and the change of tcm syndrome before and after 3.1 observation index treatments.Safety monitoring: blood, urine, feces routine examination, the heart, liver.Kidney function test, the untoward reaction that may occur.

3.2 criterions of therapeutical effect are with reference to the standard formulation of " new Chinese medicine guideline of clinical investigations (trying) ".

3.2.1 criterion of therapeutical effect clinic control: cough, expectorant, to breathe heavily and pulmonary's wheezing sound returns to level before acute attack, other objective determination indexs are normal; Effective: to cough, expectorant, to breathe heavily and pulmonary's wheezing sound significantly alleviates, but level before not returning to acute attack, other objective determination indexs are obviously improved; Effective: to cough, expectorant, to breathe heavily and pulmonary's wheezing sound alleviates, but the not enough effective person of degree, other objective determination indexs are improved; Invalid: cough, expectorant, breathe heavily and pulmonary's wheezing sound without change or increase the weight of, do not return to level before acute attack in 1 month, other objective determination indexs have no improvement and increase the weight of on the contrary.

3.2.2 tcm syndrome efficacy evaluation clinic control: clinical symptoms, sign disappear or substantially disappear, card Hou Jifen reduces >=95%; Effective: clinical symptoms, sign are obviously improved, card Hou Jifen reduces >=70%; Effective: clinical symptoms, sign all take a favorable turn, card Hou Jifen reduces >=30%; Invalid: clinical symptoms, sign are not improved, even increase the weight of, syndrome integral reduces less than 30%.

3.3 statistical methods SPSS 13.0 statistical software.Enumeration data x2 inspection, rank test; Measurement data t checks.

3.4 result

3.4.1 two groups of curative effect of disease compare in table 1.

A table 1 liang group curative effect of disease compares [example (%)]

Note: two groups of total effective rates through rank test, Z=-2.003, P=0.045, ^ap < 0.05.

3.4.2 two groups of tcm syndrome comparitive study are in table 2.

Table 2 liang group TCM syndrome comparitive study [example (%)]

Note: two groups of total effective rates through rank test, z=-2.147, P=0.032, ^ap < 0.05.

3.4.3 the clinical cardinal symptom somatic feature score difference comparsion in treatment front and back is in table 3.

Note: compare integration differential after self comparing P < 0.01, two groups treatment before and after P > 0.05, two groups treatment before two groups of treatments and compare P < 0.05.

Note: compare integration differential after self comparing & P < 0.01, two groups treatment before and after * P > 0.05, two groups treatment before two groups of treatments and compare #P < 0.05.

4 discuss

The category such as Protracted Course of Chronic Bronchitis many genus traditional Chinese medical science " endogenous cough ", " the syndrome of dyspnea ".The traditional Chinese medical science generally believes that this phase card belongs to lung spleen renal dysfunction, and the gesture of pathogenic factor has been frustrated and remaining heresy is most, and spleen transporting is lacked of proper care, kidney failure in functioning of QI, contains in phlegm-damp, so that cough with asthma protracted course of disease.Chronic bronchitis is many with insufficiency of QI of the lung and kidney, and study carefully its disease basic, lung and kidney are the dirty of Jinsui River, the lung being the dominator of QI, the kidney being the root of QI, chronic cough is wound healing lung not, and illness of the mother organ affecting the child one causes edema due to deficiency of the kidney, for expectorant is drink, upper stain is in lung, and persistent cough, a surname falls to take the photograph and receives mistake department, and touching difficulty of coughing heals.Although lung kidney two disease of ZANG-organs becomes in the majority, insufficiency of the spleen factor should not be ignored, and in old age, soil is not good for, and transporting is unable, and water paddy can not turn to precise and tiny defeated with foster lung qi, and can not descend defeated with nourishing kidney unit, gather on the contrary for expectorant is turbid, above store in lung, obstruction of lung-QI, then superinverse is for coughing.Therefore, deficiency of both the lung and kidney, the turbid interior life of expectorant are chronic bronchitis lag phase main pathogenesis.

Long-term cough consumption impairing the lung gas and lung yin, very then undermine kidney yin, occur deficiency of both QI and YIN, lung.Deficiency of the kidney yin.Therefore take supplementing QI and nourishing YIN, the method for tonifying the lung and nourishing the kidney during treatment, from intending supporting lung antitussive soup.The present invention by Fructus Schisandrae Chinensis and other mild in medicine property and Chinese medicine form and form, Fructus Schisandrae Chinensis mild in medicine property of the present invention and, can strongly invigorating primordial QI, support the five internal organs, heat extraction, flesh person in raw the moon, the special the kidney invigorating of Fructus Schisandrae Chinensis, tonifying five ZANG-organs of holding concurrently, kidney storing essence, essence is contained then cloudy strong, and receive and take the photograph, vital qi returns unit, and public region is warmed up, digesting food, steams waste matter and changes precise and tiny, then smart spontaneous, essence is raw then cloudy long, therefore main as above all diseases also." book on Chinese herbal medicine converges and says ": Fructus Schisandrae Chinensis, the medicine that astringing QI promotes the production of body fluid also.Therefore the gas of Tang Materia Medica main convergence deficiency of the lung chronic cough dissipation.All deficiency of vital energy dyspnea with rapid respiration, cough with dyspnea strains, and spirit is not enough, and arteries and veins gesture is hollow, or impairment caused by overstrain yang-energy, limbs are won thin, or empty gas is superior, and spontaneous perspiration comes frequently, or essence unit exhausts, deficiency of YIN fire is scorching, or exhaustion of YIN YANG-depletion, refreshing scattered pulse takes off, and control it with Fructus Schisandrae Chinensis, salty holding back with its acid is promoted the production of body fluid, and protects reinforcing premodial qi and without spermatorrhea also.So upper enter lung, under enter kidney, enter the benefit that lung has Jiyuan of promoting the production of body fluid, entering kidney has controlling nocturnal emission with astringent drugs to support the merit of marrow." medicineization justice ": Fructus Schisandrae Chinensis, the five tastes are salty standby, and acid solely victory, lung qi can be restrained, cure mainly asthenia chronic cough.Lid lung libido is received, if chronic cough, the burnt leaf of lung is lifted, body fluid being unable to be produced, asthenia then lung because of gas weary, excessive thirst is more than, holds back it with this, moistens it, then its dirty property, and make cough peaceful, spirit is from prosperous.But cough and can not suddenly not use for a long time, probably lung-fire is strongly fragrant holds back, pathogen beam cut-off, must be clear to the loose fire of blood, the receipts merit ear of use.Be the key medicine for the treatment of cough and asthma due to lung deficiency, but it is warm in nature dry; Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis are sweet cold, clearing lung and nourishing yin, the lung moistening and production of body fluid promoting; The Radix Rehmanniae is the principal agent of YIN nourishing, nourishing kidney yin; Fructus Schisandrae Chinensis to be astringed the lung gas, lower taste.Kidney yin, is suitable for the cough with asthma of lung kidney deficiency; Cortex Mori, Radix Stemonae clearing away lung-heat to relieve cough; Bulbus Lilii nourishing the lung to arrest cough; Radix Asteris QI invigorating, nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription.All medicines share tonifying the lung gold, kidney nourishing water, gas of astringing the lung, cough-relieving are breathed heavily, and side's card brings out the best in each other, therefore obtains satisfactory effect.

This research shows to treat with the present invention that the chronic bronchitis of pure syndrome of yin deficiency of lung and kidney is evident in efficacy is better than simple western medical treatment, and without obvious adverse reaction.

Claims

1. treat a shizandra oral liquid for YIN-deficiency type of the lung and kidney chronic bronchitis, it is characterized in that,

The parts by weight of described oral liquid crude drug comprise: Fructus Schisandrae Chinensis 10 ~ 50 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygonati 10 ~ 20 parts, Radix Ophiopogonis 10 ~ 20 parts, 10 ~ 20 parts, Poria, Placenta Hominis 10 ~ 20 parts, Bulbus Lilii 10 ~ 20 parts, Radix Adenophorae (Radix Glehniae) 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Rhizoma Polygonati Odorati 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Cortex Mori 10 ~ 20 parts, Radix Asteris 10 ~ 20 parts, Radix Asparagi 10 ~ 20 parts, the Rhizoma Anemarrhenae 10 ~ 20 parts, the Radix Stemonae 10 ~ 20 parts.

2. treat the shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis according to claim 1, it is characterized in that, the parts by weight of described oral liquid crude drug comprise: Fructus Schisandrae Chinensis 10 ~ 30 parts, 10 ~ 15 parts, the Radix Rehmanniae, Rhizoma Polygonati 10 ~ 15 parts, Radix Ophiopogonis 10 ~ 15 parts, 10 ~ 15 parts, Poria, Placenta Hominis 10 ~ 15 parts, Bulbus Lilii 10 ~ 15 parts, Radix Adenophorae (Radix Glehniae) 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Rhizoma Polygonati Odorati 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Cortex Mori 10 ~ 20 parts, Radix Asteris 10 ~ 20 parts, Radix Asparagi 10 ~ 20 parts, the Rhizoma Anemarrhenae 10 ~ 20 parts, the Radix Stemonae 10 ~ 20 parts.

3. treat the shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis according to claim 1, it is characterized in that, the parts by weight of described oral liquid crude drug comprise: Fructus Schisandrae Chinensis 10 ~ 40 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygonati 10 ~ 20 parts, Radix Ophiopogonis 10 ~ 20 parts, 10 ~ 20 parts, Poria, Placenta Hominis 10 ~ 20 parts, Bulbus Lilii 10 ~ 20 parts, Radix Adenophorae (Radix Glehniae) 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Rhizoma Polygonati Odorati 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Cortex Mori 10 ~ 15 parts, Radix Asteris 10 ~ 15 parts, Radix Asparagi 10 ~ 15 parts, the Rhizoma Anemarrhenae 10 ~ 15 parts, the Radix Stemonae 10 ~ 15 parts.

4. according to any one of claims 1 to 3, treat a preparation method for the shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis, it is characterized in that, the preparation process of described oral liquid comprises:

A. the preparation of Fructus Schisandrae Chinensis, as component 1;

5. treat the preparation method of the shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis according to claim 4, it is characterized in that, in described step a, choose Maturity high, without insect pest, without rotting, the fruit of Fructus Schisandrae Chinensis of no-sundries; During sorting, select impurity wherein, earth stone, carry out sorting with vibrosieve and rinsing bowl; Well sifted ash bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried.

6. treat the preparation method of the shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis according to claim 4, it is characterized in that, in described step a, comprise further, the Fructus Schisandrae Chinensis that dry in the sun is good is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.

7. treat the preparation method of the shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis according to claim 4, it is characterized in that, in described step b, the medicine of all the other crude drug is put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then puts into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 80 DEG C 1.36 extractum, become component 2.

8. treat the preparation method of the shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis according to claim 4, it is characterized in that, in described step c, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

9. according to any one of claims 1 to 3, treat a preparation method for the shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis, it is characterized in that, its preparation process can also be:

A. the preparation of Fructus Schisandrae Chinensis, as component 1;

B. all the other crude drug described soaked, extract 3 times as component 2;

10. treat the preparation method of the shizandra oral liquid of YIN-deficiency type of the lung and kidney chronic bronchitis according to claim 9, it is characterized in that, in described step b, all the other crude drug to be soaked in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge lixiviating solution, being condensed into pasty state becomes component 2.