CN104286864A

CN104286864A - Flatstem milkvetch seed oral liquid for improving immunity and preparation method thereof

Info

Publication number: CN104286864A
Application number: CN201410625144.6A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Hebei Senlong Pharmaceutical Technology Co., Ltd
Priority date: 2014-11-07
Filing date: 2014-11-07
Publication date: 2015-01-21
Anticipated expiration: 2034-11-07
Also published as: CN104286864B

Abstract

The invention provides flatstem milkvetch seed oral liquid for improving immunity. The flatstem milkvetch seed oral liquid is prepared from the following raw materials in parts by weight: 10-50 parts of flatstem milkvetch seed, 10-20 parts of mulberry, 10-20 parts of Chinese angelica, 10-20 parts of prepared rhizome of rehmannia, 10-20 parts of astragalus membranaceus, 10-20 parts of glossy privet fruit, 10-20 parts of semen cuscutae, 10-20 parts of rhizoma polygonati, 10-20 parts of radix codonopsis, 10-20 parts of poria cocos, 10-20 parts of fructus alpiniae oxyphyllae, 10-20 parts of human placenta, 10-20 parts of dogwood, 10-20 parts of raspberry, 10-20 parts of radix paeoniae rubrathe (unpeeled) root of common peony, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of dendrobium, 10-20 parts of Chinese magnoliavine fruit, and 10-20 parts of rhizoma acori graminei. The oral liquid uses the flatstem milkvetch seed as raw materials, and the traditional Chinese medicines which nourish liver and kidney, have moderate mouth feel and are easily accepted by people are added, so that the immunity can be obviously improved, and the situations that sub-health crowds are easy to have a cold, the eyes of the sub-health crowds are acerb, the sleep quality of the sub-health crowds is not high, and the sub-health crowds have splenic asthenia and weakness can be better improved; the oral liquid can alleviate the symptoms of reduced appetite, dry mouth, drinking and urine, deficiency of the kidney, soreness and weakness of waist and knees, impotence and seminal emission, tinnitus and blurring vision, premature graying hair, weak health and emaciation, leprosy and ringworm diseases; the oral liquid does not have toxicity or stimulus, so that the oral liquid is suitable for people to take for a long term.

Description

A kind of semen astragali complanati oral liquid improving immunity and preparation method thereof

Technical field

The present invention relates to the health products containing deriving from plant composition, particularly a kind of semen astragali complanati oral liquid improving immunity and preparation method thereof.

Background technology

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, poor appetite, failure of memory, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, a large amount of three height (high heat, high protein, higher fatty acid), more than three, (anticorrisive agent is many, flavoring agent is many, hormone is many) agricultural chemicals residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, go down to make three high disease (hypertension for a long time like this, hyperglycaemia, high fat of blood), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.

Immunity refers to that body resists external invasion and attack, safeguards the ability of homoiostasis.Various microorganism is filled with: bacterium, virus, mycoplasma, Chlamydia, fungi etc. in air.When body immunity is low, they can become the pathogen of sense mornig shift.Although human body can produce corresponding antibody to different pathogen; to resist subinfection again; but antibody has selectivity and time-bounded, such as streptococcus antibody compared with protecting body again not invade by streptococcic in short-term, also can only can not resist the infection of other viruses.The people of hypoimmunity cannot resist the invasion and attack of common cold virus at all, and this is only the true cause that Susceptible population frequently catches a cold.

Immunity plays an important role in human life mechanism, and the nutrition of human body, fatigue, mood, environment, disease, medication, radiation etc. cause the immunity degradation of self.Over millions of year, the mankind were not only applicable to existence but also the environment be fraught with risks life one, and the mankind are able to survival, also obtain outstanding immunity.Immunity is the product of biological evolution process thus.

The health of hypoimmunity is easy to infected or cancer stricken.A variety of causes makes immune system normally can not play protective effect, and in the case, very easily cause the infection such as bacterium, virus, fungi, therefore hypoimmunity the most directly shows is exactly liable to illness.Because of often ill, increased the weight of the consumption of body, thus generally have a delicate constitution, malnutritive, One's spirits are drooping, fatigue and weak, appetite reduction, the performance such as sleep-disorder, sick, have an injection and take medicine the normal potluck that just gets married.At every turn sickly all to could to recover for a long time, and usually recurrent exerbation.If things go on like this can cause health and intelligence development bad, also easily bring out major disease.Underlying causes is that hypoimmunity or immunity are unsound.When immune function of human body imbalance, or when immune system is unsound, following point will recurrent exerbation: flu recurrent exerbation, tonsillitis recurrent exerbation, asthma recurrent exerbation, bronchitis recurrent exerbation, pneumonia recurrent exerbation, diarrhoea recurrent exerbation ... so necessarily can't neglect.

Semen astragali complanati has another name called Tong puncture vine, SEMEN ASTRAGALI COMPLANATI, is the seed of the legume root of bidentate achyranthes, the annual time of the year when autumn changes into winter, fruit maturation and connect stem when not ftractureing and cut off, and lays seed, removes impurity, then dry and can be used as medicine after drying.It is warm in nature, and taste is sweet, enters liver, kidney channel, has effect of tonifying liver, kidney-nourishing, improving eyesight, controlling nocturnal emission with astringent drugs, with treating the diseases such as kidney deficiency and liver, soreness of waist and knee joint, blurred vision, seminal emission premature ejaculation, frequent urination, the enuresis, hematuria, leukorrhea." book on Chinese herbal medicine converges and says " is said: " SEMEN ASTRAGALI COMPLANATI, the medicine of the puckery essence of kidney tonifying also.Its gas delicate fragrance, can nourish the liver to improve visual acuity, moist pupil of the eye.Invigorate the kidney and stop nocturnal emission, strong sun has son, not strong not dry, and only urine of holding concurrently loses drop, be agent that peace is soft and moist also.”

Semen astragali complanati is nutritious, containing complanatoside (Complanatuside), neocomplanatoside (Neocoplanoside), myricomplanoside (Myricomplanoside), astragalin, Kaempferol (Kaempferide), myricetin (Myricetin), cupreol (β-Sitosterol). also containing 16 seed amino acids such as glutamic acid (Glutamic acid), arginine (Argini-ne), asparatate (Asparagic acid), alanine (Alanine), 10 kinds of trace elements such as iron, zinc, manganese, cobalt, chromium, copper, selenium, heptenoic acid (Heptenic acid), tetradecenoic acid (Tetradecenoic acid, myristic acid), pentadecanoic acid (Pentadecanoic acid), hexadecylic acid (Hexadecanoie acid, palmitic acid), stearic acid (Octadecanoic acid, stearic acid), octadecenoic acid (Octadecenoic acid, oleic acid), octadecadienoic acid (Octadecadienoic acid, linoleic acid), octatecatrienoic acid (Octadecatrienoicacid, linolenic acid), arachidic acid (Arachidic acid), twenty diacid (Behenic acid, behenic acid) etc. 14 kinds of aliphatic acid.Still containing polypeptide, protein, phenols, tannin, sterol and triterpenes components, alkaloid, flavones ingredient.The elements such as the fatty oil of semen astragali complanati, retinoid, alkaloid, flavonoids, phenols, tannin, protein, amino acid and selenium, copper, zinc, manganese, iron, magnesium, chromium, calcium.Seed is rich in grease, account for 5% of seed weight, at least containing 14 kinds of aliphatic acid in oil, comprise heptenoic acid, tetradecylic acid (myristic acid), pentadecanoic acid, hexadecylic acid (palmitic acid), oleic acid, stearic acid, linoleic acid, linolenic acid, arachidic acid, eicosenoic acid, behenic acid (behenic acid) etc., wherein unrighted acid accounts for 40% of total acid.Another containing cupreol.In addition, seed, still containing several amino acids, gets complanatoside (the two glycoside of complanatulside, rhamnocitrin-3,4 '-O-β-D-) from ethanol extract.

The effect of semen astragali complanati:

Antitumaous effect: in vitro test, has inhibitory action to tumour cell.Semen astragali complanati contains more bioflavonoid and has anticancer and antimutagenic effect, can the formation of Tumor suppression.

Effect for reducing fat: for feeding hyperlipidemia rats caused by feed, the semen astragali complanati general flavone being equivalent to crude drug 30g/kg dosage has significant effect for reducing blood fat, the high cholesterol of meter, triglyceride and LDL-C can be made significantly to reduce (P < 0.01), and HDL-C meter high (P < 0.05) can be made.

Hypotensive effect: increase brain blood flow.Semen astragali complanati water decoction-alcohol sedimentation liquid 0.125g/kg or 0.25g/kg intravenous injection, can make anaesthetized dog blood pressure significantly reduce (P < 0.05).Continue 30min, and decreased heart rate, cerebral blood flow (CBF) significantly strengthens (P < 0.05).

Antiaggregating activity on platelet effect: find that semen astragali complanati general flavone is when final concentration 1.25,2.5 and 5mg/ml by Bom optical densitometric method, the platelet aggregation (P < 0.01, P < 0.05) that ADP and collagen all can be suppressed significantly to cause.

Hepatoprotective effect: gavage is distinguished to normal mouse and carbon tetrachloride (CCl4) hepatic injury rat in the flavonoids position of semen astragali complanati decoction and extraction, water soluble part, total amino acid position, the decoction energy of 5g/kg significantly reduces liver glycogen (P < 0.01), triglycerides (P < 0.01) and liver total protein (P < 0.01), and sterol content in CCl4 hepatic injury rat SGPT and liver also can be made significantly to decline (P < 0.05).

Impact on immunologic function: semen astragali complanati decoction 5g/kg or 10g/kg gavages, the vigor of mouse boosting cell or serum lysozyme can be significantly improved, normal and the phytohemagglutin phytolectin (PHA) of obvious promotion stimulates lower mouse spleen mixing 3H-TdR, but do not affect the picked-up of thymus gland to 3H-TdR, do not increase spleen weight.

There is analgesia, antifatigue effect: semen astragali complanati all can extend mouse latency of pain response significantly under dosage used.Swimming test proves under dosage used.Semen astragali complanati can significant prolongation mouse swimming time.

Modern selects some health foods or functional food to be to improve the health.The function of health products mainly improves blood circulation of human body, improves body immunity.The various health products sold on the market now, dragons and fishes jumbled together for medicine, and the amusement of great majority just false propaganda, what have does not only have health-care components, also causes the huge injury of the person.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.How the efficacy exertion of semen astragali complanati not being injured human body again to maximum, and obviously improve mouthfeel, people can be accepted, is our problem in the urgent need to address.Containing a large amount of active material health products safely and effectively inside gynostemma pentaphylla, greatly can improve body immunity, be the key that people expect to deal with problems always.

Summary of the invention

Technical problem to be solved by this invention is, modern's operating pressure is large, environmental pollution is serious, tobacco and wine are immoderate, night life is uncontrolled, a lot of markets sell various health products, dragons and fishes jumbled together for medicine, the amusement of great majority just false propaganda, what have does not only have health-care components, also causes the huge injury of the person.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.How the efficacy exertion of gynostemma pentaphylla not being injured human body again to maximum, and obviously improve mouthfeel, people can be accepted, is our problem in the urgent need to address.。

The present invention take semen astragali complanati as raw material, add some nourishing liver and kidney, the gentle people of making of mouthfeel is easy to the Chinese medicine accepted, can reach that nourishing liver and kidney, beneficial the moon nourishes blood preferably, qi-restoratives benefit vital essence, dispelling pathogenic wind for improving eyesight, nourishing liver and kidney effect, add some promoting blood circulation and removing blood stasis, the Chinese medicine of invigorating spleen to remove dampness yin-nourishing, the most mouthfeel of these medicinal materials is light, do not affect the taste of semen astragali complanati, there is no the unpleasant taste of traditional Chinese medicine being difficult to swallow, make people be easy to accept, can immunity be significantly improved, sub-health population easy catching a cold can be improved preferably, eyes are sour and astringent, sleep quality is not high, insufficiency of the spleen weak; The few dry of food; Quench one's thirst; Deficiency of the kidney soreness and weakness of waist and knees; Impotence and seminal emission; Tinnitus order is dark; Poliosis; Body void is won thin; The symptom of wind favus disease, can reach the effect improving immunity preferably, the sub-health states such as Diarrhoea have very high health-care effect, and nontoxic non-stimulated, are applicable to Long-Time Service.

For solving above-mentioned technical barrier, the invention provides a kind of semen astragali complanati oral liquid improving immunity, in the semen astragali complanati oral liquid of described raising immunity, the parts by weight of various raw material can be: semen astragali complanati 10 ~ 50 parts, mulberries 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 10 ~ 20 parts, cultivated land, the Radix Astragali 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the seed of Chinese dodder 10 ~ 20 parts, sealwort 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, fructus alpiniae oxyphyllae 10 ~ 20 parts, dried human placenta 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, raspberry 10 ~ 20 parts, the radix paeoniae rubrathe 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the stem of noble dendrobium 10 ~ 20 parts, 10 ~ 20 parts, the fruit of Chinese magnoliavine, grass-leaved sweetflag 10 ~ 20 parts.

The semen astragali complanati oral liquid of described raising immunity, the parts by weight improving various raw material in the semen astragali complanati oral liquid of immunity described in it can also be: semen astragali complanati 10 ~ 30 parts, mulberries 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, 10 ~ 15 parts, cultivated land, the Radix Astragali 10 ~ 15 parts, the fruit of glossy privet 10 ~ 15 parts, the seed of Chinese dodder 10 ~ 15 parts, sealwort 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, fructus alpiniae oxyphyllae 10 ~ 20 parts, dried human placenta 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, raspberry 10 ~ 20 parts, the radix paeoniae rubrathe 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the stem of noble dendrobium 10 ~ 20 parts, 10 ~ 20 parts, the fruit of Chinese magnoliavine, grass-leaved sweetflag 10 ~ 20 parts.

The semen astragali complanati oral liquid of described raising immunity, the parts by weight improving various raw material in the semen astragali complanati oral liquid of immunity described in it also can be: semen astragali complanati 10 ~ 40 parts, mulberries 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 10 ~ 20 parts, cultivated land, the Radix Astragali 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the seed of Chinese dodder 10 ~ 20 parts, sealwort 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, fructus alpiniae oxyphyllae 10 ~ 15 parts, dried human placenta 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, raspberry 10 ~ 15 parts, the radix paeoniae rubrathe 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, the stem of noble dendrobium 10 ~ 15 parts, 10 ~ 15 parts, the fruit of Chinese magnoliavine, grass-leaved sweetflag 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method improving the semen astragali complanati oral liquid of immunity, and described in it, the preparation process of semen astragali complanati oral liquid comprises following aspect:

A. the preparation of semen astragali complanati, as component 1;

B. by described all the other bulk drugs preparation, as component 2;

C. by above-mentioned two kinds of extract components 1 and component also 2-in-1, add dextrin after concentrated and be in harmonious proportion, after disinfection, be prepared into health oral liquor.

In described step a, in the annual time of the year when autumn changes into winter, connect stem when waiting semen astragali complanati fruit maturation and do not ftracture and cut off, lay seed after drying, remove impurity, then dry.

In described step a, may further include, the semen astragali complanati shone is steeped in 10 times amount ethanol and soak more than 10 days, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, supernatant is removed after leaving standstill, then put into reduced pressure concentration tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when suction filtration to the relative density of filtrate is 20 DEG C 1.06 medicinal extract, become component and become component 1.

In described step b, all the other bulk drugs can be soaked in water 12 hours, then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filter residue adds water again, and half an hour is boiled in third time heating, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge leaching liquor, are condensed into pasty state, become component 2.

In described step c, can by component 1 and component also 2-in-1, stir evenly, be placed in 70-90% ethanol and soak 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, adds 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge leaching liquor, be condensed into pasty state filtrate, then insert in economic benefits and social benefits vacuum concentrator, add honey mediation after concentrated and make oral liquid.

For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method improving the semen astragali complanati oral liquid of immunity, and its preparation process can also be:

A. the preparation of semen astragali complanati, as component 1;

B. all the other bulk drugs described soaked, extract 3 times as component 2;

C. component 1 and component 2 are mixed, add proper honey after concentrated and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

In described step b, the preparation process of all the other raw materials can also be: get other raw materials and clean impurity elimination, steeps in the ethanol of 5-10 times amount, soaks 1-2 hour, heating extraction 2 times, each 1-2 hour, merges extract, removes supernatant after leaving standstill, then reduced pressure concentration tank is put into, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when suction filtration to the relative density of filtrate is 20 DEG C 1.06 medicinal extract; Medicinal extract above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Add honey mediation after concentrated and make oral liquid.

The technique effect that the present invention is useful is, the present invention is raw material with semen astragali complanati, and it is warm in nature, taste is sweet, enter liver, kidney channel, there is effect of tonifying liver, kidney-nourishing, improving eyesight, controlling nocturnal emission with astringent drugs, with treating the diseases such as kidney deficiency and liver, soreness of waist and knee joint, blurred vision, seminal emission premature ejaculation, frequent urination, the enuresis, hematuria, leukorrhea.The present invention take semen astragali complanati as raw material, add some nourishing liver and kidney, the gentle people of making of mouthfeel is easy to the Chinese medicine accepted, can reach that nourishing liver and kidney, beneficial the moon nourishes blood preferably, qi-restoratives benefit vital essence, dispelling pathogenic wind for improving eyesight, nourishing liver and kidney effect, add some promoting blood circulation and removing blood stasis, the Chinese medicine of invigorating spleen to remove dampness yin-nourishing, the most mouthfeel of these medicinal materials is light, do not affect the taste of semen astragali complanati, there is no the unpleasant taste of traditional Chinese medicine being difficult to swallow, make people be easy to accept, can immunity be significantly improved, sub-health population easy catching a cold can be improved preferably, eyes are sour and astringent, sleep quality is not high, insufficiency of the spleen weak; The few dry of food; Quench one's thirst; Deficiency of the kidney soreness and weakness of waist and knees; Impotence and seminal emission; Tinnitus order is dark; Poliosis; Body void is won thin; The symptom of wind favus disease, can reach the effect improving immunity preferably, the various sub-health state such as Diarrhoea has very high health-care effect, and nontoxic non-stimulated, is applicable to Long-Time Service.

Detailed description of the invention

Human immunity is the defensive enginery of human body pathogenic microorganism to external world etc., or perhaps system of defense, and under normal circumstances, it can ensure human body not by the infringement of extraneous pathogenic microorganism.The body immunity of usual theory just refers to that the immune system of human body resists the ability of the infringements such as exotic disease pathogenic microorganism.In the normal situation of body immunity, human body self can resist the infringement of considerable germ, avoids causing damage to human body.Immunity plays an important role in human life mechanism, and the nutrition of human body, fatigue, mood, environment, disease, medication, radiation etc. cause the immunity degradation of self.More and more research shows, the adjustment of Chinese medicine to body immunity more and more plays a significant role.

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, poor appetite, failure of memory, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, a large amount of three height (high heat, high protein, higher fatty acid), more than three, (anticorrisive agent is many, flavoring agent is many, hormone is many) agricultural chemicals residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, go down to make three high disease (hypertension for a long time like this, hyperglycaemia, high fat of blood), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.A variety of causes makes immune system normally can not play protective effect, and in the case, very easily cause the infection such as bacterium, virus, fungi, therefore hypoimmunity the most directly shows is exactly liable to illness.Because of often ill, increased the weight of the consumption of body, thus generally have a delicate constitution, malnutritive, One's spirits are drooping, fatigue and weak, appetite reduction, the performance such as sleep-disorder, sick, have an injection and take medicine the normal potluck that just gets married.At every turn sickly all to could to recover for a long time, and usually recurrent exerbation.If things go on like this can cause health and intelligence development bad, also easily bring out major disease.Underlying causes is that hypoimmunity or immunity are unsound.When immune function of human body imbalance, or when immune system is unsound, following point will recurrent exerbation: a flu recurrent exerbation, tonsillitis recurrent exerbation, asthma recurrent exerbation, bronchitis recurrent exerbation, pneumonia recurrent exerbation, diarrhoea recurrent exerbation ... so necessarily can't neglect.

Liver controlling conveyance and dispersion, the general reference comprehensive physiological functions such as irritability has dredging, bar reaches, liter is sent out, freely let out.Ancients rush with wood gas the catharsis function resembling analogy liver reached with bar, therefore are belonged to wood in the five-element, therefore " the blue secret allusion quotation opinion of Plain Questions spirit " is said: " liver person; organ of general considers and here ", " Plain Questions six saves state of internal organs opinion " is said: " liver person; source of endurance, the residence of soul also ".The function of liver controlling conveyance and dispersion is mainly manifested in and regulates spiritual feelings will, promotes to digest and assimilate, and maintains operation three aspect of qi and blood, body fluid.

Liver opening at eye, it is foster that objective vision function mainly relies on moistening of the cloudy blood of liver; The passages through which vital energy circulates first line of a couplet order system again of liver.Therefore, whether normal the function of liver is usually reflects on order.Such as: blurred vision, yctalopia can appear in deficiency of liver-blood; Deficiency of the yin of the liver, then two xerophtalmias, hypopsia; Liver-fire flaming, then red eye, swell pain.The traditional Chinese medical science is emphasized, people wants frequent dispersing liver-energy, clearing liver poison, falls irascibility, nourishing the liver blood, and dispersing liver-energy can make the catharsis of whole body mechanism of qi unobstructed, in body on stifled then face without acne; Clearing liver poison can dissolve elimination internal pollution, and in body, nontoxic then face is without dead color; Fall irascibility and can make equilibrium between yin and yang in body, in body, not burnt then skin moisturizing is not dry; Nourishing the liver blood can nourish whole body internal organs, and liver blood is full, and then body surface gloss is flexible.Repair damaged liver, make whole body mechanism of qi free flow of qi, the smooth and easy operation of whole body qi and blood, to reach soothing the liver beauty treatment object.Toxigenic source is liver.When liver can not complete removing toxic substances work well, toxin is just stretched in vivo.First soothing the liver beauty treatment starts with from liver health, allows healthy liver complete every removing toxic substances work, thoroughly cuts off toxin source, make appearance beautiful lastingly.

Motherland's medical science is thought for liver-kidney Yin deficiency, fatty liver, reduces phlegm, promoting blood circulation and removing blood stasis mainly with clearing damp, and 'Shugan Lidan ', regulating spleen and stomach is the rules for the treatment of.The present invention is made up of semen astragali complanati, the fruit of Chinese magnoliavine, the fruit of glossy privet etc., and in side, the fruit of glossy privet enters liver and gall warp, soothing liver-qi stagnation, clearing heat and promoting diuresis; The red sage root is clearing heat and detoxicating; Fruit of Chinese magnoliavine convergence is astringent or styptic treatment for spontaneous sweating, nourishing generate fluid.All medicines share, and have dispersing stagnated hepatoqi, heat-clearing nourishing the liver, eliminating damp, detoxifying, reinforcing spleen to promote digestion, fall enzyme, the effect of fat of dispelling.

Mulberries nourishing yin and nourishing blood medicine; Promote the production of body fluid medicine; Aperitive.To enrich blood enriching yin, promote the production of body fluid and moisturize.For dizzy tinnitus, palpitation and insomnia, poliosis, Tianjin wound is thirsty, and interior heat is quenched one's thirst, blood deficiency and constipation.Tonifying liver, kidney-nourishing, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control liver-kidney Yin deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Both can food, can be used as medicine again, the traditional Chinese medical science thinks the sweet acid of mulberries taste, and cold nature, enters the heart, liver, kidney channel, is strengthening by means of tonics, the good fruit of intelligence development of nourishing heart.There is enriching yin of enriching blood, promote the production of body fluid to quench thirst, the effects such as ease constipation is dry, cure mainly deficiency of YIN-blood and having a dizzy spell of causing, tinnitus palpitaition, irritated insomnia, soreness and weakness of waist and knees, poliosis, dry of quenching one's thirst, the diseases such as dry and hard excrement.

Radix Angelicae Sinensis, its taste is sweet and weigh, therefore specially can enrich blood, and its gas is light and pungent, therefore again can promoting circulation of blood, and bowl spares has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, tonifying Qi production of sperm, five viscera settling, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery.Empty and the exterior syndrome being not relieved person of battalion, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, can fall apart greatly Biao Weire, and show not hold back person, helps with rheum officinale and so on, can admittedly show again.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Cultivated land has another name called prepared rhizome of rehmannia or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese medicine, there is enriching yin effect of enriching blood, can be used for the deficiency of blood sallow, dizzy, palpitation and insomnia, irregular menstruation, the diseases such as uterine bleeding, also diseases such as can be used for hectic fever hectic fever due to yin, the night sweat of the deficiency of the kidney yin, pass out semen, quench one's thirst is one of asthenic symptoms class non-prescribed medicine medicine Liuwei Dihuang Wan main component.This quality is moistened into kidney, and kind nourishing kidney yin, life essence-filling, marrow-benefitting is the key medicine of tonifying kidney-yin.Ancients call it " large tonifying five zang organs is Kidney-Yin ", " the true water of large benefit ".Often be equal to use with Chinese yam, Fructus Corni, the treatment deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst, can filling liver kidney, beneficial marrow, as Liuwei Dihuang Wan.

The Radix Astragali has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely.But table is real evil to be contained, retention of dampness due to stagnation of QI, and dyspepsia is stagnated, ulcer from the beginning of or the real example such as routed after heat poison Shang Sheng.The Radix Astragali has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, and ulcer difficulty is burst, and burst for a long time and do not hold back, the deficiency of blood is sallow, and interior heat is quenched one's thirst." herbal classic " is recorded: " main ulcer, loses sore for a long time, apocenosis pain relieving.Qi-restoratives, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas to strengthen the bone, put on flesh and enrich blood.”

Radix Codonopsis is traditional tonic that China commonly uses, and the Radix Codonopsis that ancient times produce with area, Shangdang, Shanxi is top grade, has tonifying middle-Jiao and Qi, effect of invigorating the spleen benefit lung.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, saponin and Alkaloid, has develop immunitypty, hemangiectasis, step-down, improves microcirculation, strengthens the effects such as hematopoiesis function.In addition the leucocyte caused chemotherapy radiotherapy declines and has castering action.Radix Codonopsis has tonifying middle-Jiao and Qi, effect of invigorating the spleen benefit lung.Weak for the spleen deficiency syndrome of the lung, palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst." new compilation of materia medica " is recorded: " tonifying middle-Jiao and Qi and taste, relieving thirst and restlessness.Middle gas is faint, mends in order to adjust, very smooth and proper.”

Fructus alpiniae oxyphyllae taste is pungent; Warm in nature, enter the heart, spleen; Kidney channel.Effect: warm kidney controlling nocturnal emission with astringent drugs contracting urine, phlegm is taken the photograph in warm spleen appetizing.Cure mainly deficiency-cold in spleen and stomach; Vomiting; Have loose bowels; Coldly in abdomen to educate; The many salivas of mouth; Enuresis with renal asthenia; Frequent micturition; Seminal emission; Gonorrhoea, the diseases such as many salivas.Fructus alpiniae oxyphyllae is containing volatile oil, fructus alpiniae oxyphyllae ketone, vitamin B1, vitamin B2, vitamin C, vitamin E and several amino acids, aliphatic acid etc.Fructus alpiniae oxyphyllae decoction has the effect of stomach invigorating, antidiuresis, minimizing salivary secretion.Its water extract has suppression ascitogenous sarcoma S180.The effect that cell increases.Its water extract and ethanol extract have the effect suppressing ileum contraction.In addition, its methanolic extract have strengthen left atrium contracts power, suppress potassium chloride to cause exempt from the effect such as activity that sustainer shrinks and suppress prostaglandin synthetase

Dried human placenta, refer to the placenta of the mankind, the traditional Chinese medical science is thought, placenta nature and flavor are sweet, one-tenth, temperature, enter lung, the heart, kidney channel, have tonifying kidney and benefiting sperm, the merit of nourishing qi and blood.Modern medicine study is thought, placenta contains protein, sugar, calcium, vitamin, immune factor, female sex hormone, helps progesterone, steroid hormone, promoting sexual gland hormone, corticotropin etc., the growth of mammary gland, uterus, vagina, testis can be promoted, also facilitation is had to thyroid gland, also there is good effect to pulmonary tuberculosis, bronchial astehma, anaemia etc., grind oral or bowel lavage into powder and can prevent measles or mitigation symptoms.Also certain curative effect is had to portal cirrhotic ascites and blood fluke property end-age cirrhosis ascites.Record in the Compendium of Material Medica of Li Shizhen (1518-1593 A.D.): " in the pregnant tire of youngster, navel lies in mother, the female ridge of tire system, and by the shade of mother, the female blood of father's essence, is harmonious and forms.Though the shape of the day after tomorrow, obtain congenital gas in fact, obviously his metal and stone vegetation non-and so on compared.The merit of its nourishing is extremely heavy, and take clear-headed and clear-sighted for a long time, beard and hair is pitch-black, promotes longevity ".Compatriots know from ancient times " placenta " for nourishing is top grade, it can fundamentally cure and regulate the physiological function of each organ of human body, the senile cell in human activin and cytothesis function, makes that parts of body physiological function returns to several years, state even decades ago, make people full of vitality, full of vigour

The radix paeoniae rubrathe: bitter, cold nature.Return Liver Channel.There is the function of clearing heat and cooling blood, blood stasis removing analgesic.The raw radix paeoniae rubrathe wins with clearing heat and cooling blood power.The body heat being used for warm disease heat invading xuefen is hemorrhage, red eye, swell pain, carbuncle sore tumefacting virus.The wine radix paeoniae rubrathe: with promoting blood circulation to remove blood stasis power victory, clearing heat and cooling blood effect is more weak.Be used for amenorrhoea or dysmenorrhoea, traumatic injury.The radix paeoniae rubrathe to purify the blood point real heat, and loose hemostasis is detained.This product function is close with the root bark of tree peony, therefore normal and root bark of tree peony mutual reinforcement between is for use.But the effect of root bark of tree peony clearing heat and cooling blood is better, can purify the blood a point real heat, can control fever due to yin deficiency again; And the radix paeoniae rubrathe can only be used for the real heat of blood system, be good at promoting blood circulation to remove blood stasis.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil is to mouse EC, lymphosarcoma ascitic type, cancer of the esophagus Ecal09), sarcoma 180 etc. has inhibitory action.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.Energy main large wandering arthritis, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under stopping.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells to vomit inverse, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

The stem of noble dendrobium: reinforcing stomach reg fluid is nourishing Yin and clearing heat.Hinder body fluid deficiency for the moon, dry polydipsia, food is few retches, and abnormal heat after being ill, order is secretly failed to understand.The stem of noble dendrobium is famous yin-nourishing class Chinese medicine, and its sweet cold air is clear, energy clearing lung-heat heat, and nourishing stomach-YIN, raw kidney water, beneficial vital essence, reducing the asthenic fever is replenishing the vital essence and removing heat, reinforcing stomach reg fluid key medicine.Simultaneously its clear fire mutually and take the photograph vigour, kidney nourishing water and soft liver-yin, be listed in top grade in Shennong's Herbal.Impact on immunologic function: mouse gavaging HERBA DENDROBII decocting liquid 0.5mg/ only, totally 6 days, has obvious facilitation to the function of peritoneal macrophage, but can not improving heavy dose of hydrogen, to examine caused macrophage function low.In addition, anti-ageing in addition, blood glucose increasing and faint pain relieving antipyretic effect.，

Its slightly warm in nature of grass-leaved sweetflag, taste is pungent, have have one's ideas straightened out, the phlegm that slits, regulate the flow of vital energy, invigorate blood circulation, loose wind, the effect of drying, be usually used in the disease such as treatment epilepsy, coma due to blocking of the respiratory system, pyreticosis coma, forgetful, deafness with qi stagnation, ambition unhappiness, stomachache, stomachache, arthralgia due to wind-dampness, swollen ulcer drug, traumatic injury.Dampness elimination is whetted the appetite, open-minded phlegm of having one's ideas straightened out, inducing resuscitation intelligence development.Not hungry for gastral cavity ruffian, a mouthful diarrhea of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, coma due to blocking of the respiratory system, pyreticosis coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, wind-cold-dampness arthralgia, swollen ulcer drug, traumatic injury." herbal classic ": main wind-cold-dampness arthralgia, cough with dyspnea, happy hole, tonifying five zang organs, logical nine orifices, improve visual and auditory acuity, goes out speech." not Lu ": " warming intestines and stomach, only little facility, four limbs arthritis with fixed pain caused by dampness, must not bend and stretch, children's's a kind of malaria, and body accumulated heat is not understood, and can do to bathe soup for main deafness, carbuncle sore.Clever knowledge, beneficial intelligence." " property of medicine opinion ": " controls rheumatoid arthritis stubborn, tinnitus, head wind, under tear, kills parasites, controls and dislikes sore scabies scabies.

The seed of Chinese dodder is listed in top grade in Shennong's Herbal.Its smell is pungent, sweet, flat nontoxic.Function with cure mainly: tonifying kidney and benefiting sperm, nourish the liver to improve visual acuity.The waist knee muscles and bones being applicable to kidney deficiency and liver is ached, legs and feet are weak and feeble, impotence and seminal emission, crazy talk, frequent urination, dripping urination, dizzy, the disease such as blurring of vision, Hiccough and deaf and women is with down, habitual abortion.Generally be listed in top grade can taking for a long time, take improving eyesight for a long time and make light of one's life by commiting suicide and prolong life.But deficiency of yang hyperactivity of fire, penis ultroerection not impotence and dry feces person prohibit clothes, according to individual physique, if there is sign of getting angry, just cut out.It can causing property hyperfunction.

Raspberry temperature; Sweet, sour; Return kidney, urinary bladder channel.For kidney-nourishing, controlling nocturnal emission with astringent drugs, contracting urine.Treatment enuresis with renal asthenia, frequent urination, impotence and premature ejaculation, emission and spermatorrhea." property of medicine opinion ": " main man's kidney-jing deficiency exhausts, woman's food have son.Main impotence." " Japan hanako materia medica ": " five viscera settling, beneficial color, supports vital essence, long hair, Qiang Zhi.Treat apoplexy body heat and shy." " Kaibao Bencao " carries it: " qi-restoratives is absolutely continuous, reinforcing yin essence Jianyang, smoothing skin, peace and internal organs, and Wen Zhongyi power treats strain wind empty, tonifying liver improving eyesight." " Bencao Jingshu ": " raspberry, its main beneficial gas person, says beneficial vital essence also.Kidney storing essence, kidney receive gas, and vital essence is sufficient, then body is from light, send out white.Respectful main qi-restoratives of reviving is absolutely continuous, reinforcing yin essence Jianyang, smoothing skin, peace and internal organs.The main man's kidney-jing deficiency of Zhen Quan exhausts, impotence, woman's food have son.Large bright main five viscera settling, beneficial color, supports vital essence, long hair, Qiang Zhi.All get its kidney-nourishing and add essence, the adopted ear of sweet acid convergence." " explaining abstruseness of the canon of materia medica ": raspberry, sweetly puts down into kidney, and play a sun and control impotence, controlling nocturnal emission with astringent drugs is taken the photograph excessive, strong kidney and without scorching partially, controlling nocturnal emission with astringent drugs and evil puckery undoubtedly, the product of gold and jade are also.

Poria cocos taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is put down, and enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, is reached by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, being with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the root of herbaceous peony, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.

Sealwort is used as medicine with rhizome.There is boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions.Be used for the treatment of weakness of the spleen and the stomach, fatigue and asthenia, dry food is few, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, and interior heat such as to be quenched one's thirst the disease.Very effective in cure for diabetes.Stir-baked RHIZOMA POLYGONATI with yellow rice wine is also known as processing sealwort.The person of being used as medicine is dried for clean sealwort steams rear section with the auxiliary material such as wine and black soya bean.Have the merit of channels and collaterals of escaping concurrently.Sealwort has hypotensive, hypoglycemic, reducing blood lipid, atherosclerosis, and delay senility and effect such as antibacterial grade, Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.For the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, and the labor of lung-kidney deficiency is coughed chronic cough etc.For weakness of the spleen and the stomach.Both tonifying spleen-yin, again beneficial temper, obtain dizzy, soreness and weakness of waist and knees for deficiency of kidney essence, poliosis and quenching one's thirst.Sealwort strengthens the bone, beneficial marrow, bleaches and sends out; The cough phlegm be suitable for caused by lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.

Fruit of Chinese magnoliavine temperature; Sour, sweet; Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.Breathe heavily for void of coughing for a long time, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and feeble pulse of losing heart, interior heat is quenched one's thirst, palpitation and insomnia.Fruit is made Chinese medicine function nourishing generate fluid, nourshing kidney of astringing the lung, antidiarrheal, puckery essence, is calmed the nerves, and can control the diseases such as chronic cough void is breathed heavily, dry is lacked in Tianjin, seminal emission is rushed down for a long time, forgetful insomnia.Schisandra fruit implementation Chinese medicine function nourishing generate fluid, nourshing kidney of astringing the lung, antidiarrheal, puckery essence, to calm the nerves, can control that chronic cough void is breathed heavily, the disease such as the few dry in Tianjin, seminal emission are rushed down for a long time, forgetful insomnia.Pharmacological testing proves excitement and the process of inhibition that can regulate central nervous system, promotes body metabolism, and regulate gastric juice and bile secretion, to hepatitis convalescence transaminase, rising person has reducing effect." book on Chinese herbal medicine converges and says ": the fruit of Chinese magnoliavine, the medicine that astringe qi promotes the production of body fluid also.The gas of the dissipation therefore the main convergence deficiency syndrome of the lung of Tang Materia Medica is coughed for a long time.All dyspnea due to deficiency of vital energy are anxious, and cough inverse strain, spirit is not enough, and arteries and veins gesture is hollow, or internal lesion caused by overexertion yang-energy, limbs are won thin, or empty gas is superior, and spontaneous perspiration comes frequently, or essence unit exhausts, deficiency of Yin fire is scorching, or yin depletion yang depletion, the loose arteries and veins of god takes off, and controls it with the fruit of Chinese magnoliavine, becomes to hold back with its acid to promote the production of body fluid, and protects reinforcing premodial qi and nothing left is let out also.So upper enter lung, under enter kidney, enter the benefit that lung has Jiyuan of promoting the production of body fluid, entering kidney has controlling nocturnal emission with astringent drugs to support the merit of marrow.Cruel and the alcohol of fruit of Chinese magnoliavine main component schizandrin, the fruit of Chinese magnoliavine, its mechanism of action suppresses the vigor of transaminase in Hepatocyte, and induced microparticle body produces cytochrome P-450, the detoxification ability of enhance hepatocyte, and can promote hepatocellular reparation

The order that the fruit of glossy privet is used for the deficiency of liver-yin and kidney-yin is secretly failed to understand, hypopsia, poliosis, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Control order secretly to fail to understand, often join cultivated land, root tuber of aromatic turmeric is equal to use, controls poliosis, and often join the same use of mulberries, fever due to yin deficiency, often joins the root bark of Chinese wolf-berry.The deficiency of liver-yin and kidney-yin, Light-headedness, seminal emission tinnitus, soreness and weakness of waist and knees, poliosis, coronary heart disease, hyperlipidemia, hypertension, chronic hepatitis.The protective effect research of liver is thought, the fruit of glossy privet contains oleanolic acid, to rat skin lower injection, serum glutamic pyruvic transminase can be reduced, there is obvious protective effect to the hepatic injury of Carbon Tetrachloride Induced, and can liver cell regeneration be promoted. oleanolic acid also can make triglycerides accumulation minimizing in liver, degeneration of liver cells necrosis obviously alleviates, glycogen accumulation increases, serum γglobulin declines; Ultra microstructure visible liver cell mitochondrial swelling and endosomal vesicle sex change alleviate, hepatic tissue interstitial inflammation habituation.

Fructus Corni, cure mainly perverse trend fever and chills under the heart, Wen Zhong, by cold temperature numbness, goes three worms, for a long time clothes made light of one's life by commiting suicide reinforcing yin essence benefit essence, five viscera settling, logical nine orifices, stop the merit of dribbling urination; Take improving eyesight, brute force for a long time all the year round.Fructus Corni, have another name called cornus officinalis sieb et zucc, medicine jujube, real jujube, fructus corni, meat jujube etc., for China commonly uses rare traditional Chinese medicine, applicating history is long.It is gentle with its benefit power, establishing-Yang and do not help fire, enriching yin and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Zhang Zhongjing is that monarch has formulated " chinkuei shin chewan pills " with Fructus Corni.According to chemical analysis, Fructus Corni contains the active ingredients such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, anti-inflammatory, the pharmacological action such as antibacterial, is the medicine simply commonly used in tcm clinical practice.

Specific embodiment 1:

First semen astragali complanati is gathered in the crops, airing.

Again the semen astragali complanati that airing is good is steeped in ethanol and extract, as component 1.

Then by all the other raw material mulberries, Radix Angelicae Sinensis, cultivated land, the Radix Astragali, the fruit of glossy privet, the seed of Chinese dodder, sealwort, Radix Codonopsis, Poria cocos, fructus alpiniae oxyphyllae, dried human placenta, Fructus Corni, raspberry, the radix paeoniae rubrathe, the bighead atractylodes rhizome, the stem of noble dendrobium, the fruit of Chinese magnoliavine, grass-leaved sweetflag, adds water or alcohol extract, as component 2.

Finally by two kinds of extract mixing, concentrated, add dextrin or honey mediation, filling bottle, becomes oral liquid.

Specific embodiment 2:

In the annual time of the year when autumn changes into winter, connect stem when waiting semen astragali complanati fruit maturation and do not ftracture and cut off, lay seed after drying, remove impurity, then dry.

General for the semen astragali complanati shone 5000g is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, supernatant is removed after leaving standstill, then put into reduced pressure concentration tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when suction filtration to the relative density of filtrate is 20 DEG C 1.06 medicinal extract, become component and become component 1.

By all the other bulk drug mulberries 1500g, Radix Angelicae Sinensis 1500g, cultivated land 1500g, Radix Astragali 1500g, fruit of glossy privet 1500g, seed of Chinese dodder 1500g, sealwort 1500g, Radix Codonopsis 1500g, Poria cocos 1500g, fructus alpiniae oxyphyllae 1500g, dried human placenta 1500g, Fructus Corni 1500g, raspberry 1500g, radix paeoniae rubrathe 1500g, bighead atractylodes rhizome 1500g, stem of noble dendrobium 1500g, fruit of Chinese magnoliavine 1500g, grass-leaved sweetflag 1500g, to soak in water 12 hours, then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filter residue adds water again, and half an hour is boiled in third time heating, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge leaching liquor, are condensed into pasty state, become component 2.

By component 1 and component also 2-in-1, stir evenly, be placed in 70-90% ethanol and soak 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges leaching liquor, is condensed into pasty state filtrate, insert in economic benefits and social benefits vacuum concentrator again, add honey mediation after concentrated and make oral liquid.

Specific embodiment 3:

By the general 4000g of semen astragali complanati shone, steep in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, becomes component 1.

Get other raw material mulberries 1200g again, Radix Angelicae Sinensis 1100g, cultivated land 1200g, Radix Astragali 1100g, fruit of glossy privet 1200g, seed of Chinese dodder 1100g, sealwort 1200g, Radix Codonopsis 1200g, Poria cocos 1200g, fructus alpiniae oxyphyllae 1100g, dried human placenta 1200g, Fructus Corni 1200g, raspberry 1200g, radix paeoniae rubrathe 1200g, bighead atractylodes rhizome 1100g, stem of noble dendrobium 1200g, fruit of Chinese magnoliavine 1100g, grass-leaved sweetflag 1200g, clean and dry, in 70 DEG C of baking ovens, dry 8-12h, take out and be placed in cooling in drying box, pulverized 80-100 mesh sieve with pulverizer; To be soaked the particle that sieves in water 12 hours, then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filter residue adds water again, and half an hour is boiled in third time heating, filters, and heating is concentrated into paste, as component 2, and stand for standby use.

Two kinds of extracts are placed in 70-90% ethanol and soak 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges leaching liquor, is condensed into pasty state filtrate, add honey again or dextrin reconciles into oral liquid, canned.

Specific embodiment 4:

The semen astragali complanati 3000g shone is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, stand for standby use, becomes component 1.

Get other raw material mulberries 1000g again, Radix Angelicae Sinensis 1100g, cultivated land 1200g, Radix Astragali 1100g, fruit of glossy privet 1200g, seed of Chinese dodder 1100g, sealwort 1200g, Radix Codonopsis 1200g, Poria cocos 1000g, fructus alpiniae oxyphyllae 1100g, dried human placenta 1200g, Fructus Corni 1200g, raspberry 1200g, radix paeoniae rubrathe 1200g, bighead atractylodes rhizome 1100g, stem of noble dendrobium 1200g, fruit of Chinese magnoliavine 1100g, grass-leaved sweetflag 1200g, put into 10 times amount ethanol by surplus stock component, No. 2 extracts each 1 ~ 2 hour, are merged and leave standstill by heating and refluxing extraction 2 times; The dregs of a decoction of the component raw medicinal material crossed by above-mentioned alcohol extract again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by No. 2 extracts and leave standstill; Merged by above-mentioned two kinds of extracts, reduced pressure concentration relative density is the filtrate of 1.35 (80 DEG C), reclaims ethanol, and by gained filtrate adjustment proportion to 1.06, reduce pressure to obtain medicinal extract, then adds honey or dextrin mediation, canned.

Pharmacological toxicity is tested

One, test material:

(1) animal used as test: mouse NIH, body weight 25-28g, male and female half and half; Rats Wistar body weight 130-160g, male and female half and half, the feed of rat, mouse is provided by Shandong medical college animal experimental center.

(2) test medicine:

1, medicine of the present invention: the oral liquid prepared by embodiment 2, applies with distilled water diluting during three batch equal amount of mixture experiments.

2, positive control medicine: chinkuei shin chewan pills, commercially available.

Two, test method and result:

(1) get the healthy mice 80 of body weight 25-28g, female, hero half and half, is divided into four groups respectively by sex and body weight, often organizes 20.1, take the present invention for 2,3 groups, dosage is respectively 8.6g crude drug/kg/d, 6.4g crude drug/kg/d, 4.2g crude drug/kg/d, and take positive control drug chinkuei shin chewan pills for the 4th group, dosage is 6g crude drug/kg/d, is used in conjunction 15 days.

Result of the test: 1,2,3 groups of mouse obviously strengthen than 4 groups of mouse heat degree, the number of copulations of 1,2,3 group of mouse average every day increases by 3 times than the number of copulations of 4 groups of mouse.

Result of the test shows that medicine of the present invention has obvious excitation to central nervous system, thus medicine of the present invention for adjustment human body function equilibrium, beneficial gas, enrich blood, delaying senility strengthens metabolism, neurolysis, sexual hypofunction has treatment foundation.

(2) body weight 100-130g healthy rat 40 is got, male and female half and half, measure serum total cholesterol (TC), HDL (HDL-C) calculate TC/HDL-C ratio, then four groups are divided at random, often organize 10,1, take the oral liquid prepared by the embodiment of the present invention 2 respectively for 2,3 groups, dosage is respectively 8.6g crude drug/kg/d, 6.4g crude drug/kg/d, 4.2g crude drug/kg/d.Take chinkuei shin chewan pills for 4th group, 6g crude drug/kg/d, is used in conjunction 15 days, and result of the test shows that medicine of the present invention has antagonism.

Animal acute toxicity test of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-22g, are provided by Shandong medical college Animal Lab..

(2) test medicine: oral solutions prepared by the embodiment of the present invention 3, is diluted with distilled water into suspension.

Two, test method and result:

Mouse maximum tolerance determination: get healthy mice 32, male and female half and half, divided three groups within 24 hours, and only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestines, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mouse administration routinely feed within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the oral liquid prepared by the embodiment of the present invention 3.

(2) animal used as test, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and all death in 12 days is observed in remaining 1/2 drug withdrawal.

Two, test index

(1) general status comprises body weight, diet, mood, movable energy.

(2) hemogram checking: red blood cell count(RBC), white blood cell count(WBC), platelet count, blood picture etc., quantitative hemoglobin counts.

(3) biochemical analysis, haemocyanin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, stomach and intestine, bladder, adrenal gland does pathologic diagnosis.

Three, result of the test: show through rat chronic toxicity test, with the heavy dose of bowel lavage of the present invention six months, increases the growth of rat, body weight, all has no side effect to brain, Liver and kidney function.Do not find that infringement changes to each histoorgan of rat, the circulatory system, medication group compares no significant difference with control group.Illustrate that medicine of the present invention has warming and invigorating kidney Yang, beneficial gas, enriches blood, delay senility drug effects such as strengthening metabolism, non-toxic.

Pharmacology test one

We observe the impact of health care oral liquid of the present invention on hypoimmunity mice immunologic function, prove that the present invention has certain effect really to immunity raising, existing by as follows for result of study report:

1 materials and methods

(the self-control of 1.1 experiment material oral liquid of the present invention, prepare by the method for specific embodiment 2), (Hengrui Medicine Co., Ltd., Jiangsu Prov. produces syklofosfamid ampoule, specification: 0.1g, lot number: 20080602), phytohemagglutin phytolectin (available from Sigma), RPMI-1640 (purchased from American Hyclone company), (Shandong medical sci-tech serum factory produces newborn calf serum, lot number: 20090607006), four thiazole salts (MTT), dimethyl sulfoxide (DMSO) (DMSO); Kunming mice (animal used as test factory of University Of Qingdao product); ELIASA (U.S. Thermo Fisher Scientific Co., Ltd produces, model: MultiskanMK3), CO2 incubator (U.S. Thermo Fisher Scientific Co., Ltd produces, model: Thermo Scientific 3110).

1.2 experimental technique

1.2.1 the preparation of liquid: get oral liquid of the present invention, one bottle of about 10-15ml, is equivalent to 48mg crude drug.

1.2.2 divide into groups: 48 mouse are divided into 4 groups, blank group (NS, 0.9% sodium chloride injection 20ml/kg), endoxan (CTX) control group (40mg/kg), CTX+ 2.4g/kg high dose group (high dose group) of the present invention, CTX+ 0.6g/kg low dose group of the present invention, often organizes 12.The impact of the present invention on mouse immune organ, macrophage phagocytic function, lymphopoiesis situation is detected after each group of difference gavage 1 time/continuous 14d of d, 1ml/d.

1.2.3 immunologic function Testing index

1.2.3.1 immune organ quality: cervical dislocation takes weight after putting to death mouse, take out thymus gland and spleen immediately, weigh after blotting residual blood with filter paper (mg), with the ratio of the quality of thymus gland, spleen (mg) with weight (g), as the index of thymus gland, spleen, thymus gland (spleen) organ index=Organ weight (mg)/weight (g).

1.2.3.2 phagocytic function: 3d before execution animal, the starch meat soup of lumbar injection 5% activates mouse macrophage, adopt half intracorporal method to detect Peritoneal Macrophage Phagocytosis, the number (phagocytic index) of the macrophage number (phagocytic rate) and each macrophage phagocytic chicken red blood cell of engulfing chicken red blood cell in 100 macrophages is as evaluation index.

1.2.3.3T detection (mtt assay) the Con A of lymphopoiesis ability stimulates the detection of mice spleen lymphocytes proliferation ability: take out spleen under aseptic condition after cervical dislocation puts to death mouse, spleen surface blood is rinsed with 0.9% sodium chloride solution, be placed in mortar, add RPMI1640 nutrient solution, grind to form single cell suspension, with 1000rmin ^-1rotating speed is centrifugal abandons supernatant, washs 2 times, be resuspended in RPMI1640 nutrient solution with Hanks ' liquid.Regulate cell concentration to 3 × 106/ml, a point holes adds in 24 well culture plates, every hole 1ml.One hole adds 75 μ l ConA liquid, another hole in contrast, put 37 DEG C, 5%CO2 incubator interior cultivation 72h, stop cultivating the front every hole of 4h and add 10 μ l MTT, after cultivation terminates, inhale and abandon supernatant, every hole adds DMSO 1ml, ELIASA surveys OD value in 570nm, deducts the OD value not adding ConA hole represent lymphopoiesis ability with the OD value adding ConA hole.

1.3 statistical method application SPSS13.0 softwares are to data analysis, and measurement data represents with (-x ± s), adopt variance analysis.Inspection level is α=0.05.

2 results

2.1 Oral Liquid On Mice immune organ quality of the present invention affect CTX control group immune organ thymus gland, index and spleen index all lower than blank group, have statistical significance (P < 0.01) with blank group comparing difference.Oral liquid high and low dose group immune organ thymus gland of the present invention, index and spleen index are apparently higher than CTX control group, and compare with CTX control group, difference has statistical significance (P < 0.05, in table 1).

Table 1 oral liquid of the present invention is on the impact (x ± s, mg/g) of ionization radiation injury mouse immune organ organ index

Group	Mouse (only)	Thymus index	Spleen index
				Blank group	12	8.32±0.37	7.35±0.43
CTX control group	12	4.26±0.17Δ	5.49±0.23Δ
				High dose group of the present invention	12	7.04±0.37**	6.67±0.22**
Low dose group of the present invention	12	5.89±0.42**	5.69±0.16*

Note: compare with blank group, Δ P < 0.01; Compare with CTX control group, * P < 0.05, * * P < 0.01.CTX=endoxan

The impact of 2.2 Oral Liquid On Mice monokaryon-peritoneal macrophage phagocytic activities of the present invention

CTX control group phagocytic percentage, phagocytic index are all lower than blank group, statistics (P < 0.01) is had with blank group comparing difference, oral liquid high and low dose group phagocytic percentage of the present invention, phagocytic index are apparently higher than CTX control group, compare with CTX control group, difference has statistics (P < 0.05, in table 2).

Table 2 compound medlar tea in bag is on Phagocytosis By The Peritoneal Macrophages In Mice and lymphopoietic impact (-x ± s)

Note: compare with blank group, Δ P < 0.01; Compare with CTX control group, * P < 0.05, * * P < 0.01

3 discuss

Human immunity is the defensive enginery of human body pathogenic microorganism to external world etc., or perhaps system of defense, and under normal circumstances, it can ensure human body not by the infringement of extraneous pathogenic microorganism.The body immunity of usual theory just refers to that the immune system of human body resists the ability of the infringements such as exotic disease pathogenic microorganism.In the normal situation of body immunity, human body self can resist the infringement of considerable germ, avoids causing damage to human body.Immunity plays an important role in human life mechanism, and the nutrition of human body, fatigue, mood, environment, disease, medication, radiation etc. cause the immunity degradation of self.More and more research shows, the adjustment of Chinese medicine to body immunity more and more plays a significant role.This experimental result shows, the present invention can improve the competence for added value of the organ index of endoxan immunogenicity decline mouse immune organ, macrophages phagocytic capacity and T cell, tentative confirmation the present invention can make tea and have humidification to the immunity of hypoimmunity mouse.

Semen astragali complanati has the effects such as antiallergic action, Central nervous depressant, the propagation protecting the liver, strengthen muscular strength and inhibition cancer cell, it is warm in nature, taste is sweet, enter liver, kidney channel, there is effect of tonifying liver, kidney-nourishing, improving eyesight, controlling nocturnal emission with astringent drugs, with treating the diseases such as kidney deficiency and liver, soreness of waist and knee joint, blurred vision, seminal emission premature ejaculation, frequent urination, the enuresis, hematuria, leukorrhea.To treatment hepatitis, hypotensive, doctor's carbuncle, enrich blood, brain tonic, anticancer and invigorating the spleen keep fit to have special effect.Description of test, gavage is distinguished to normal mouse and carbon tetrachloride (CCl4) hepatic injury rat in the flavonoids position of semen astragali complanati decoction and extraction, water soluble part, total amino acid position, the decoction energy of 5g/kg significantly reduces liver glycogen (P < 0.01), triglycerides (P < 0.01) and liver total protein (P < 0.01), and sterol content in CCl4 hepatic injury rat SGPT and liver also can be made significantly to decline (P < 0.05).Impact on immunologic function: semen astragali complanati decoction 5g/kg or 10g/kg gavages, the vigor of mouse boosting cell or serum lysozyme can be significantly improved, normal and the phytohemagglutin phytolectin (PHA) of obvious promotion stimulates lower mouse spleen mixing 3H-TdR, but do not affect the picked-up of thymus gland to 3H-TdR, do not increase spleen weight.

Specific embodiment: Chen, man, 39 years old, in first visit in January, 2013.Readme is white collar, assumes the leadership in company, and pressure is very large.Often catch a cold recently, the weary unable dizziness of panesthesia burnout body, eyes are dry and astringent, fuzzy viewing.And insomnia and dreamful sleep, easily dry, hypoimmunity; Couple's sexual life is had a heart but no strength, and starts to occur erectile problem, even premature ejaculation, and family relationship is nervous.Remove examination in hospital blood item, B ultrasonic has no organic disease.Through looking into, suit the medicine to the illness, patient is because of work strain, and psychological pressure is large, and then increased the weight of the consumption of body, original sufferer has a delicate constitution, nutrition is unbalanced thus feel One's spirits are drooping, fatigue and weak, love life are discord, night pollakiuria, appetite reduce, sleep-disorder; Sick, have an injection and take medicine the normal potluck that just gets married.At every turn sickly all will could to recover for a long time, and because taking medicine throughout the year, to produce resentment to medicine, suggestion oral liquid of the present invention replaces taking Chinese medicine.

Fang Yong: semen astragali complanati 30g, mulberries 12g, Radix Angelicae Sinensis 14g, cultivated land 12g, Radix Astragali 12g, fruit of glossy privet 13g, seed of Chinese dodder 14g, sealwort 12g, Radix Codonopsis 12g, Poria cocos 11g, fructus alpiniae oxyphyllae 13g, dried human placenta 14g, Fructus Corni 12g, raspberry 12g, radix paeoniae rubrathe 13g, bighead atractylodes rhizome 13g, stem of noble dendrobium 12g, fruit of Chinese magnoliavine 11g, grass-leaved sweetflag 11g, makes oral liquid, every day 2 times, each 2 bottles, strengthen taking exercise, every day runs.After taking 10 days, patient is conscious, and all diseases are improved, and sleep-disorder lowers, and One's spirits are drooping improvement, fatigue and weak improve, have rosy cheeks, no longer lassitude.Continue to take 1 month, sleep, the state of mind is good, and readme love life is harmonious.Continue use month all disease more all to disappear, full of vitality, radiate the vigour of youth.

Claims

1. one kind is improved the semen astragali complanati oral liquid of immunity, it is characterized in that, in the semen astragali complanati oral liquid of described raising immunity, the parts by weight of various raw material comprise: semen astragali complanati 10 ~ 50 parts, mulberries 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 10 ~ 20 parts, cultivated land, the Radix Astragali 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the seed of Chinese dodder 10 ~ 20 parts, sealwort 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, fructus alpiniae oxyphyllae 10 ~ 20 parts, dried human placenta 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, raspberry 10 ~ 20 parts, the radix paeoniae rubrathe 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the stem of noble dendrobium 10 ~ 20 parts, 10 ~ 20 parts, the fruit of Chinese magnoliavine, grass-leaved sweetflag 10 ~ 20 parts.

2. improve the semen astragali complanati oral liquid of immunity according to claim 1, it is characterized in that, in the semen astragali complanati oral liquid of described raising immunity, the parts by weight of various raw material comprise: semen astragali complanati 10 ~ 30 parts, mulberries 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, 10 ~ 15 parts, cultivated land, the Radix Astragali 10 ~ 15 parts, the fruit of glossy privet 10 ~ 15 parts, the seed of Chinese dodder 10 ~ 15 parts, sealwort 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, fructus alpiniae oxyphyllae 10 ~ 20 parts, dried human placenta 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, raspberry 10 ~ 20 parts, the radix paeoniae rubrathe 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, the stem of noble dendrobium 10 ~ 20 parts, 10 ~ 20 parts, the fruit of Chinese magnoliavine, grass-leaved sweetflag 10 ~ 20 parts.

3. improve the semen astragali complanati oral liquid of immunity according to claim 1, it is characterized in that, in the semen astragali complanati oral liquid of described raising immunity, the parts by weight of various raw material comprise: semen astragali complanati 10 ~ 40 parts, mulberries 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 10 ~ 20 parts, cultivated land, the Radix Astragali 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the seed of Chinese dodder 10 ~ 20 parts, sealwort 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, fructus alpiniae oxyphyllae 10 ~ 15 parts, dried human placenta 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, raspberry 10 ~ 15 parts, the radix paeoniae rubrathe 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, the stem of noble dendrobium 10 ~ 15 parts, 10 ~ 15 parts, the fruit of Chinese magnoliavine, grass-leaved sweetflag 10 ~ 15 parts.

4. as described in any one of claims 1 to 3 item, improve a preparation method for the semen astragali complanati oral liquid of immunity, it is characterized in that, the preparation process of described semen astragali complanati oral liquid comprises:

A. the preparation of semen astragali complanati, as component 1;

B. by described all the other bulk drugs preparation, as component 2;

5. improve the preparation method of the semen astragali complanati oral liquid of immunity according to claim 4, it is characterized in that, in described step a, in the annual time of the year when autumn changes into winter, connect stem when waiting semen astragali complanati fruit maturation and do not ftracture and cut off, after drying, lay seed, remove impurity, then dry.

6. improve the preparation method of the semen astragali complanati oral liquid of immunity according to claim 4, it is characterized in that, in described step a, comprise further, the semen astragali complanati shone is steeped in 10 times amount ethanol and soak more than 10 days, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, supernatant is removed after leaving standstill, then put into reduced pressure concentration tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when suction filtration to the relative density of filtrate is 20 DEG C 1.06 medicinal extract, become component and become component 1.

7. improve the preparation method of the semen astragali complanati oral liquid of immunity according to claim 4, it is characterized in that, in described step b, to be soaked by all the other bulk drugs in water 12 hours, then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filter residue adds water again, and half an hour is boiled in third time heating, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge leaching liquor, are condensed into pasty state, become component 2.

8. improve the preparation method of the semen astragali complanati oral liquid of immunity according to claim 4, it is characterized in that, in described step c, by component 1 and component also 2-in-1, stir evenly, be placed in 70-90% ethanol and soak 1-2 hour, 60 DEG C-70 DEG C are heated in water-bath, lixiviate 2h, every 10min stirs once, by filtered through gauze, 50-60% ethanol is added in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merge leaching liquor, be condensed into pasty state filtrate, insert in economic benefits and social benefits vacuum concentrator again, add honey mediation after concentrated and make oral liquid.

9. according to any one of claims 1 to 3, improve a preparation method for the semen astragali complanati oral liquid of immunity, it is characterized in that, its preparation process can also be:

A. the preparation of semen astragali complanati, as component 1;

B. all the other bulk drugs described soaked, extract 3 times as component 2;

10. improve the preparation method of the semen astragali complanati oral liquid of immunity according to claim 9, it is characterized in that, in described step b, the preparation process of all the other raw materials can also be: get other raw materials and clean impurity elimination, steep in the ethanol of 5-10 times amount, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merges extract, removes supernatant after leaving standstill, then reduced pressure concentration tank is put into, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when suction filtration to the relative density of filtrate is 20 DEG C 1.06 medicinal extract; Medicinal extract above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount; Add honey mediation after concentrated and make oral liquid.