CN110893230A

CN110893230A - Traditional Chinese medicine composition for improving immunity

Info

Publication number: CN110893230A
Application number: CN201911391575.XA
Authority: CN
Inventors: 张炳强; 陈梦梦; 刘翠娟
Original assignee: Qingdao Re-Store Biotech Co Ltd
Current assignee: Qingdao Re-Store Biotech Co Ltd
Priority date: 2019-12-30
Filing date: 2019-12-30
Publication date: 2020-03-20

Abstract

The invention provides a traditional Chinese medicine composition for improving immunity, which has the functions of improving immunity, resisting infection and preventing and resisting cancer and is prepared from the following components: 20-40 parts of shiitake mushroom, 20-40 parts of sea cucumber dry powder, 20-40 parts of cordyceps militaris, 20-40 parts of Chinese yam, 10-20 parts of astragalus membranaceus, 2-5 parts of cynomorium songaricum, 2-5 parts of epimedium, 2-5 parts of mulberry, 2-5 parts of gardenia root, 1-2 parts of cynanchum paniculatum, 1-2 parts of melastoma dodecandrum, 1-2 parts of mussel flower, 1-2 parts of dried ginger, 1-2 parts of Japanese ardisia herb and 1-2 parts of anise root. The traditional Chinese medicine raw materials are dried according to the formula proportion, crushed into fine powder of 100 meshes and 200 meshes, and uniformly mixed to prepare granules, thus obtaining the finished product. Compared with the prior art, the traditional Chinese medicine composition provided by the invention has the advantages of safety, effectiveness, high cost performance and the like, and can improve immunity.

Description

Traditional Chinese medicine composition for improving immunity

Technical Field

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for improving immunity.

Background

Immunity is the physiological response of the human body to recognize and eliminate "isohexia". The immune system performs this function in the human body. When the immune system fails to exert its protective effect for various reasons, it is very likely to cause infection of bacteria, viruses, fungi, etc.

The most direct manifestation of low immunity is that it is easy to get ill. The frequent illness aggravates the consumption of the organism, so the general manifestations of weak constitution, malnutrition, listlessness, fatigue, weakness, appetite reduction, sleep disorder and the like exist, and the patients with illness, injection and medication become the frequent meals of the home. Recovery from each illness can take a long time and often attacks repeatedly. This causes physical and intellectual development failure and also induces serious diseases.

At present, health care products or medicines for resisting fatigue and improving immunity in the market have a plurality of varieties, and the trend is to use natural medicines such as Chinese herbal medicines and the like as raw materials to prepare the medicines and the health care products for resisting fatigue.

The mushroom is delicious in taste, is deeply popular with the public and can be used as both medicine and food, is the second most edible fungus in the world, is called as mountain delicacy king, is high in protein and low in fat, can increase the metabolism of a human body when being eaten frequently, enables the human vigor to be vigorous, contains high-molecular-weight polysaccharide, can improve the immunity of the human body and can help prevent cold.

The sea cucumber is high in protein, low in fat and low in sugar, and is rich in various essential amino acids, vitamins, essential fatty acids, major elements and trace elements.

The Cordyceps militaris is rich in cordycepin, Cordyceps polysaccharide, etc. Cordycepin is a nucleoside substance with antibacterial activity, and has strong inhibitory effect on nuclear polyadenylic acid polymerase. Make mRNA mature in the process of DNA transcription mRNA and inhibit the growth of cancer cells. Cordyceps polysaccharide is a highly branched galactomannan, and can promote lymphocyte transformation, improve antibody content of serum IgG and immunity of organism, and enhance anticancer ability of organism.

Astragalus root, radix astragali, invigorating qi and raising yang, invigorating qi and expelling toxin, is called as ten health preserving Chinese medicinal materials. Chinese yam is used for tonifying spleen and qi, nourishing spleen and yin and securing essence. The combination of the two can nourish qi without stagnation, nourish without greasy and stagnation, and can achieve the effect of tonifying spleen qi and nourishing spleen yin.

Cynomorium songaricum has the effects of invigorating kidney, replenishing vital essence, and moistening dryness, and can be used for treating sexual impotence, spermatorrhea, soreness of waist and knees, constipation due to intestinal dryness, paralysis and sexual hypofunction improvement.

Herba Epimedii is pungent, sweet and warm in flavor and acts on liver and kidney, is a key herb for tonifying Mingmen, replenishing vital essence and qi, strengthening tendons and bones, tonifying kidney and strengthening yang, and is clinically used for treating male impotence, spermatorrhea, premature ejaculation, urinary incontinence, female infertility and other symptoms. Modern researches show that epimedium contains icariin, volatile oil, ceryl alcohol, phytosterol, tannin, vitamin E and other components. Can excite sexual function, and promote semen secretion for animals. It also has blood pressure lowering (peripheral vasodilation inducing), blood glucose lowering, diuretic, antitussive, expectorant, and vitamin E-like effects. Pharmacological experimental research shows that epimedium can increase blood flow of heart and cerebral vessels, promote hemopoiesis, immunity and bone metabolism, and has the functions of resisting senility, resisting tumor, etc. The research of the Singapore medical experts shows that the epimedium can effectively kill the breast cancer cells, but the epimedium is still required to be further researched clinically.

The mulberry contains main nutritional components such as moisture, sugar, crude protein, ash, crude fiber, free acid, soluble nitrogen-free substances and the like, and in addition, the mulberry also contains essential amino acids for human bodies, easily absorbed polysaccharide, abundant vitamins, haematochrome and mineral substances such as calcium, iron, zinc, selenium and the like which are deficient in human bodies, has the effects of enhancing immunity, promoting the growth of hematopoietic cells, promoting metabolism and the like, and has abundant nutritional value and certain pharmacological value.

The gardenia root has the effects of clearing heat, promoting diuresis, cooling blood and stopping bleeding. Can be used for treating icterohepatitis, dysentery, cholecystitis, common cold, hyperpyrexia, hematemesis, epistaxis, urinary tract infection, nephritis edema, mastitis, toothache due to pathogenic wind-fire, skin sore, carbuncle, toxic swelling, and traumatic injury.

Cynanchum paniculatum, radix Cynanchi Paniculati is pungent in flavor, warm in nature, enters stomach and liver meridians. Has the functions of dispelling wind, eliminating dampness, relieving pain and stopping itching. Can be used for treating rheumatalgia, gastralgia, toothache, traumatic injury, rubella, and eczema.

Melastoma dodecandrum lour is sweet and astringent in flavor and neutral in nature, and enters liver and spleen meridians. Has the effects of nourishing blood, stopping bleeding, astringing intestine and controlling nocturnal emission. Can be used for treating blood deficiency, asthenia, hematemesis, epistaxis, excessive internal injury, hemoptysis, hematochezia, metrorrhagia, spermatorrhea, leukorrhagia, dysentery, rectocele, scald, and traumatic hemorrhage.

The mussel flower is sweet and light in flavor and cool in nature. Has the effects of clearing heat, eliminating phlegm, cooling blood and stopping dysentery. Can be used for treating cough due to lung dryness, hemoptysis, pertussis, tuberculous lymphadenitis, dysentery, and hematochezia.

Gan Jiang is pungent in flavor and warm in nature, and enters spleen, stomach, kidney, heart and lung meridians. Has the effects of warming the middle-jiao and dispelling cold, restoring yang and promoting blood circulation, and warming lung and resolving fluid retention. Can be used for treating abdominal psychroalgia, emesis, diarrhea, cold limbs, slight pulse, cough and asthma due to cold fluid retention.

Shi Di cha is mild in nature, pungent and slightly bitter in flavor, and enters lung and liver meridians. Resolve phlegm and stop cough, remove dampness by diuresis, activate blood. Can be used for treating cough, bloody sputum, chronic bronchitis, jaundice due to damp-heat pathogen, and traumatic injury.

Fennel root, pungent and sweet in flavor, warm in nature, warms kidney and regulates middle energizer, promotes qi circulation to alleviate pain.

In the traditional Chinese medicine composition, three traditional Chinese medicines originally used for cooling blood and stopping bleeding, such as gardenia root, mussel flower, melastoma dodecandrum and the like, are creatively found to have a positive immunoregulation effect, and cynanchum paniculatum is creatively found to have a positive immunoregulation effect, and the four components have a synergistic effect, so that the combined use formula can exert the maximum effect. The dried ginger in the traditional Chinese medicine composition can warm the middle-jiao to dispel cold, and the aniseed root can warm the kidney to harmonize the middle, and is used for neutralizing the blood cooling effect of gardenia root, mussel flower and Melastoma dodecandrum.

Disclosure of Invention

The technical task of the invention is to solve the defects of the prior art, provide a traditional Chinese medicine composition which does not contain chemical drugs and hormone drugs and can improve immunity, and has the functions of enhancing immunity, resisting infection, preventing and resisting cancer;

a traditional Chinese medicine composition for improving immunity is prepared from the following components: 20-40 parts of shiitake mushroom, 20-40 parts of sea cucumber dry powder, 20-40 parts of cordyceps militaris, 20-40 parts of Chinese yam, 10-20 parts of astragalus membranaceus, 2-5 parts of cynomorium songaricum, 2-5 parts of epimedium, 2-5 parts of mulberry, 2-5 parts of gardenia root, 1-2 parts of cynanchum paniculatum, 1-2 parts of melastoma dodecandrum, 1-2 parts of mussel flower, 1-2 parts of dried ginger, 1-2 parts of Japanese ardisia herb and 1-2 parts of anise root.

The preparation method comprises the following steps: the traditional Chinese medicine raw materials are dried according to the formula proportion, crushed into fine powder of 100 meshes and 200 meshes, and uniformly mixed to prepare granules, thus obtaining the finished product.

A traditional Chinese medicine composition for improving immunity is prepared from the following components: 30 parts of shiitake mushroom, 30 parts of sea cucumber dry powder, 30 parts of cordyceps militaris, 30 parts of Chinese yam, 15 parts of astragalus membranaceus, 4 parts of cynomorium songaricum, 4 parts of epimedium herb, 4 parts of mulberry, 4 parts of gardenia root, 1 part of cynanchum paniculatum, 1 part of melastoma dodecandrum, 1 part of mussel flower, 1 part of dried ginger, 1 part of Japanese ardisia herb and 1 part of anise root.

The specific implementation mode is as follows:

example 1

The formula is as follows:

30 parts of shiitake mushroom, 30 parts of sea cucumber dry powder, 30 parts of cordyceps militaris, 30 parts of Chinese yam, 15 parts of astragalus membranaceus, 4 parts of cynomorium songaricum, 4 parts of epimedium herb, 4 parts of mulberry, 4 parts of gardenia root, 1 part of cynanchum paniculatum, 1 part of melastoma dodecandrum, 1 part of mussel flower, 1 part of dried ginger, 1 part of Japanese ardisia herb and 1 part of anise root.

Example 2

The formula is as follows:

20 parts of shiitake mushroom, 20 parts of sea cucumber dry powder, 20 parts of cordyceps militaris, 20 parts of Chinese yam, 10 parts of astragalus membranaceus, 2 parts of cynomorium songaricum, 2 parts of epimedium herb, 2 parts of mulberry, 2 parts of gardenia root, 1 part of cynanchum paniculatum, 1 part of melastoma dodecandrum, 1 part of mussel flower, 1 part of dried ginger, 1 part of Japanese ardisia herb and 1 part of anise root.

The preparation method is the same as that of example 1.

Example 3

The formula is as follows:

40 parts of shiitake mushroom, 40 parts of sea cucumber dry powder, 40 parts of cordyceps militaris, 40 parts of Chinese yam, 20 parts of astragalus membranaceus, 5 parts of cynomorium songaricum, 5 parts of epimedium, 5 parts of mulberry, 5 parts of gardenia root, 2 parts of cynanchum paniculatum, 2 parts of melastoma dodecandrum, 2 parts of mussel flower, 2 parts of dried ginger, 2 parts of Japanese ardisia herb and 2 parts of anise root.

The preparation method is the same as that of example 1.

EXAMPLE 4 Effect of the Chinese medicinal composition of the present invention on the growth of S-180 cell sarcoma in mice

The resuscitated S-180 cells were injected into the mouse abdominal cavity for subculture at 0.3 mL/mouse. Seven days later, ascites from S-180 inoculated mice were aseptically aspirated and diluted to l.times.10 with physiological saline⁷Cell suspension at a concentration of 0.2 mL/cell (2X 10)⁶Individual cells) were inoculated subcutaneously into mice (18-22 g) right anterior axilla. After 24h, the mice were immediately divided into a negative control group, a traditional Chinese medicine composition group and a positive control group, and 10 mice in each group. The traditional Chinese medicine composition is mixed with normal saline, the intragastric administration (150 mg/kg) is carried out for 20 days continuously, the negative control group is intragastric administered with the same amount of normal saline every day, and the positive control group is Cyclophosphamide (CTX). The day after the last administration, the mice were weighed, sacrificed by cervical dislocation, stripped of tumor mass, and the tumor inhibition rate was calculated according to the formula:

tumor inhibition rate (%) (tumor weight of negative control group-tumor weight of treatment group)/tumor weight of negative control group × 100%

The thymus and spleen were dissected and weighed, and spleen index and thymus index were calculated as follows:

spleen index SI ═ spleen weight/body weight

Thymus index TI is thymus weight/body weight

Table 1: the traditional Chinese medicine composition has the function of inhibiting the growth of tumor cells

The experimental results are shown in table 1, and it can be seen that the Chinese medicinal composition has the effect of inhibiting the tumor growth of S-180 sarcoma mice, and can obviously restore the immune function of the tumor mice.

Example 5

Zhangqi, male, 42 years old, first diagnosis in 3 months in 2014. The self-describing is white-collar, which is a leader in companies and is very stressful. Recently, people often catch cold, feel fatigue, weakness, dizziness, dry eyes and unclear vision. And insomnia and dreaminess, easy dryness, low immunity, and no organic lesions in B-ultrasound. According to the investigation, the patient is stressed in work and has high psychological pressure to further aggravate the consumption of the body, and the patient is physically weak and unbalanced in nutrition, so feels listlessness, fatigue and weakness, discordant couple life, frequent nocturia, reduced appetite and sleep disorder; if the patient is ill, the patient can take the medicine with injection and become a family to have a meal. The recovery can be realized for a long time when the patient is ill every time, and the medicine is contradicted by taking the medicine all the year round.

After taking the traditional Chinese medicine composition for two weeks, patients can improve subjective symptoms, reduce sleep disorder, improve listlessness, improve fatigue and weakness, have ruddy complexion, do not feel tired any more, and improve immunity. After the medicine is continuously taken for one month, the sleep is good, the mental state is good, and the immunity is obviously improved. After two months of continuous administration, the health is enhanced, the immunity is completely improved, and the cold and fever are avoided.

Example 6

120 patients with hypoimmunity, which are 12-75 years old, are divided into 2 groups of 60 people each, half of both men and women. The effects of the Chinese medicinal composition of the present invention and placebo were evaluated according to the following criteria after three consecutive months, and the results are shown in Table 2.

Effect evaluation criteria:

the effect is shown: the immunity is obviously improved, the physique is obviously enhanced, the limbs are powerful, the energy is abundant, the complexion is obviously improved, the symptoms such as color spots, dark skin and the like disappear or are obviously improved, and the sub-health state in the aspects of sleeping, digestion and the like is obviously improved;

improvement: the immunity is improved, the physique is enhanced, the four limbs are more powerful, the energy and the complexion are improved to a certain extent, the symptoms such as color spots, dark skin and the like are improved, and the sub-health state in the aspects of sleeping, digestion and the like is also improved;

and (4) invalidation: the symptoms and various examinations did not improve.

TABLE 2 Effect of the Chinese medicinal composition of the present invention on Immunity

As can be seen from the table 2, the traditional Chinese medicine composition provided by the invention can obviously improve the immunity of the organism, and the total effective rate can reach 96%.

Claims

1. A traditional Chinese medicine composition for improving immunity is characterized by being prepared from the following components: 20-40 parts of shiitake mushroom, 20-40 parts of sea cucumber dry powder, 20-40 parts of cordyceps militaris, 20-40 parts of Chinese yam, 10-20 parts of astragalus membranaceus, 2-5 parts of cynomorium songaricum, 2-5 parts of epimedium, 2-5 parts of mulberry, 2-5 parts of gardenia root, 1-2 parts of cynanchum paniculatum, 1-2 parts of melastoma dodecandrum, 1-2 parts of mussel flower, 1-2 parts of dried ginger, 1-2 parts of Japanese ardisia herb and 1-2 parts of anise root;

the traditional Chinese medicine raw materials are dried according to the formula proportion, crushed into fine powder of 100 meshes and 200 meshes, and uniformly mixed to prepare granules, thus obtaining the finished product.

2. The traditional Chinese medicine composition for improving immunity according to claim 1, which is characterized by being prepared from the following components: 30 parts of shiitake mushroom, 30 parts of sea cucumber dry powder, 30 parts of cordyceps militaris, 30 parts of Chinese yam, 15 parts of astragalus membranaceus, 4 parts of cynomorium songaricum, 4 parts of epimedium herb, 4 parts of mulberry, 4 parts of gardenia root, 1 part of cynanchum paniculatum, 1 part of melastoma dodecandrum, 1 part of mussel flower, 1 part of dried ginger, 1 part of Japanese ardisia herb and 1 part of anise root.