CN112569324A - Coix seed and codonopsis pilosula composition capable of tonifying spleen and clearing damp and preparation method of composition - Google Patents
Coix seed and codonopsis pilosula composition capable of tonifying spleen and clearing damp and preparation method of composition Download PDFInfo
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- CN112569324A CN112569324A CN202010130386.3A CN202010130386A CN112569324A CN 112569324 A CN112569324 A CN 112569324A CN 202010130386 A CN202010130386 A CN 202010130386A CN 112569324 A CN112569324 A CN 112569324A
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Abstract
The invention provides a coix seed and codonopsis pilosula composition for tonifying spleen and clearing damp and a preparation method thereof, and the coix seed and codonopsis pilosula composition for tonifying spleen and clearing damp comprises the following raw materials in parts by weight: 5-20 parts of coix seed extract, 5-20 parts of phaseolus calcaratus extract, 5-20 parts of pawpaw extract, 5-20 parts of Chinese yam extract, 4-12 parts of bighead atractylodes rhizome extract, 15-30 parts of codonopsis pilosula extract, 15-30 parts of astragalus extract, 4-12 parts of poria cocos extract, 4-12 parts of wrinkled gianthyssop extract, 4-12 parts of fructus amomi extract, 0.01-0.05 part of vitamin C, 0.001-0.005 part of vitamin E and 0.01-0.05 part of taurine. The coix seed and codonopsis pilosula composition disclosed by the invention can fundamentally realize the purposes of eliminating dampness and dampness by tonifying spleen and clearing dampness, relieving exterior syndrome and eliminating dampness, tonifying spleen and qi and enhancing the coordination function of lung, spleen and kidney.
Description
Technical Field
The invention relates to the technical field of health care medicines, and particularly relates to a coix seed and codonopsis pilosula composition for tonifying spleen and clearing damp and a preparation method thereof.
Background
Body moisture is a state of sub-health, and the dampness is divided into internal dampness and external dampness. For patients with external dampness, exogenous pathogenic factors invade the human body due to rain, damp living environment and the like; the damp accumulation is caused by the inability to transport and transform the damp in patients who are addicted to the greasy food and the spleen deficiency. TCM holds that in the six pathogenic factors of wind, cold, summer-heat, dampness, dryness and fire, the dampness belongs to the damp pathogen. Dampness is the source of all diseases, usually internal dampness is the most, and the dampness in vivo becomes cold dampness when meeting cold, so as to cause inflammation and pain of joints and muscles; when the head or face is heated, the head or face is greasy, the stool is not shaped, the defecation is sticky (not easy to wash away), the moisture is sticky to the intestines, and the head or face cannot be pulled cleanly; wind can cause rheumatism and form rheumatism. The moisture enters the subcutaneous part, the fat burning efficiency is reduced, so that obesity and swelling are formed, and diseases such as fatty liver, hypertension, heart and cerebral vessels are easily induced. Excessive dampness in the body, yellow and greasy tongue coating, fatigue, dizziness, deep body, soreness of limbs, and no essence; women have an increased leucorrhea, an unpleasant taste and inflammation.
The main reasons for the accumulation of moisture in the body are: eating uncooked, cold and greasy food for a long time, improper diet, drinking, impairment of human body yang qi, bad living habits, staying up all night, greedy and air-conditioned, work tension, stress, mood depression, lack of exercise, sedentary, no sweating and metabolism retardation.
Moisture is easy to accumulate and difficult to remove, and is easy to repeat, and how to remove moisture and dampness is mainly to change living habits, light diet, little cold and greasy food, relax mood and relieve stress; the traditional Chinese medicine considers that dampness elimination firstly strengthens spleen, and dampness in vivo is mainly caused by the deficiency of lung, spleen and kidney qi, especially the deficiency of spleen qi, which causes the dysfunction of transportation and transformation of the spleen, thus causing water dampness accumulation.
However, the pharmaceutical composition for eliminating dampness and invigorating qi provided by the prior art generally has the defects of poor drug effect, no efficacy of strengthening spleen and kidney, and the like. The invention relates to a method for removing dampness and eliminating dampness by food therapy, which utilizes traditional Chinese medicine food materials to fundamentally realize the purposes of removing dampness and eliminating dampness by strengthening spleen and eliminating dampness, relieving exterior syndrome and removing dampness, tonifying spleen and qi, and enhancing the coordination function of lung, spleen and kidney.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides the coix seed and codonopsis pilosula composition for tonifying spleen and clearing damp and the preparation method thereof.
In order to achieve the purpose, the invention is realized by the following technical scheme:
the coix seed and codonopsis pilosula composition for tonifying spleen and clearing damp comprises the following raw materials in parts by weight: 5-20 parts of coix seed extract, 5-20 parts of phaseolus calcaratus extract, 5-20 parts of pawpaw extract, 5-20 parts of Chinese yam extract, 4-12 parts of bighead atractylodes rhizome extract, 15-30 parts of codonopsis pilosula extract, 15-30 parts of astragalus extract, 4-12 parts of poria cocos extract, 4-12 parts of wrinkled gianthyssop extract, 4-12 parts of fructus amomi extract, 0.01-0.05 part of vitamin C, 0.001-0.005 part of vitamin E and 0.01-0.05 part of taurine.
Preferably, the coix seed and codonopsis pilosula composition comprises the following raw materials in parts by weight: 10-15 parts of coix seed extract, 10-15 parts of phaseolus calcaratus extract, 10-15 parts of pawpaw extract, 10-15 parts of Chinese yam extract, 5-10 parts of bighead atractylodes rhizome extract, 20-25 parts of codonopsis pilosula extract, 20-25 parts of astragalus extract, 5-10 parts of poria cocos extract, 5-10 parts of wrinkled gianthyssop extract, 5-10 parts of fructus amomi extract, 0.01-0.03 part of vitamin C, 0.001-0.002 part of vitamin E and 0.01-0.03 part of taurine.
Wherein the preparation method of the mixed extract consisting of the coix seed extract, the phaseolus calcaratus extract, the pawpaw extract, the Chinese yam extract and the bighead atractylodes rhizome extract comprises the following steps:
the method comprises the following steps: weighing 10-15 parts of coix seed, 10-15 parts of phaseolus calcaratus, 10-15 parts of pawpaw, 10-15 parts of Chinese yam and 5-10 parts of bighead atractylodes rhizome according to parts by weight, selecting, cleaning, drying, crushing into 10-30-mesh coarse powder, and mixing for later use;
step two: adding water into the mixed coarse powder obtained in the step one, and extracting twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under hot reflux, and collecting the first filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 8: 1, extracting for 1.5h under reflux, collecting secondary filtrate, and combining the two filtrates;
step three: concentrating the extract under reduced pressure until the relative density is 1.0-1.08, and mixing the extract according to the weight ratio M: adding maltodextrin into the M maltodextrin (1: 0.1), and spray drying to obtain mixed extract.
Preferably, the spray drying conditions in the third step are that the air inlet temperature is 165-175 ℃, the air outlet temperature is 80-90 ℃, and the pressure in the tower is-35 to-40 Pa.
The preparation method of the freeze-dried powder comprising the ageratum extract and the fructus amomi extract, such as fructus amomi, and the like, comprises the following steps:
the method comprises the following steps: weighing 5-10 parts of wrinkled gianthyssop herb and 5-10 parts of fructus amomi according to parts by weight;
step two: cleaning, oven drying, pulverizing into 0.2-0.5cm pieces, and mixing;
step three: according to mass ratio M mixture: adding 95% ethanol into the mixture at a ratio of 1:8, leaching for 12h at 40-50 ℃, filtering, removing filter residue, concentrating the ethanol extract under reduced pressure, recovering ethanol, and freeze-drying to obtain freeze-dried powder of fructus Amomi and the like.
The preparation method of the coix seed and codonopsis pilosula composition for tonifying spleen and eliminating dampness comprises the following steps:
(1) weighing 20-25 parts of astragalus, 20-25 parts of codonopsis pilosula and 5-10 parts of poria cocos according to parts by weight, cutting into small fragments of 0.2-0.5cm, and mixing for later use;
(2) adding 10 times of water into the small fragments obtained in the step (1), carrying out hot reflux extraction for 2 times, each time for 2 hours, and combining the two extracting solutions;
(3) concentrating and evaporating the extracting solution obtained in the step (2) until the specific gravity d is 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol into the precipitate, washing, and drying under reduced pressure to obtain crude polysaccharide extract of radix Codonopsis and radix astragali;
(4) weighing the rest raw materials according to the formula proportion, mixing the rest raw materials, the mixed extract, the freeze-dried powder of fructus amomi and the like and the crude polysaccharide extract of codonopsis pilosula and astragalus, uniformly mixing, and granulating to obtain the medicine.
Coix seed is sweet in taste and slightly cold in nature. The coix seed comprises the following main components: contains protein, fat, starch, various amino acids, coixol, triterpenoid, trace elements and the like, and has the nutritional value which is the first of cereal foods. The pearl barley is the most used medicinal and edible medicinal material, can invigorate the spleen and strengthen the middle warmer, promote diuresis and eliminate dampness, can clear heat and discharge pus, and treat diseases caused by excessive dampness in the body, such as obesity, difficult movement and pain of muscle joints, and symptoms of difficult urination, edema, abdominal distension and the like of patients.
The phaseolus calcaratus is a medicinal and edible medicinal material, contains more nutrient substances such as protein, dietary fiber, vitamin A, vitamin E, potassium, magnesium, phosphorus and the like, has the effects of resolving dampness and tonifying spleen, has the built effects of tonifying spleen and eliminating dampness for people with weakness of spleen and stomach, and also has the effects of relieving summer heat, clearing heat and toxin, invigorating stomach, relaxing bowel, reducing blood fat, regulating blood sugar, building body and losing weight and the like.
The pawpaw mainly contains triterpenes, organic acids, flavonoids, polysaccharides and other active ingredients. The pawpaw is warm in nature, has the effects of dredging channels and activating collaterals, removing arthralgia and relieving pain, and resolving dampness and removing turbidity, and is suitable for removing summer heat and dampness in summer and treating diseases such as joint ache, channel spasm, neck pain and the like caused by excessive dampness. Pawpaw can enter stomach channel, harmonize stomach and promote digestion, and is good at treating dyspepsia, indigestion, anorexia, stomach fluid deficiency, dry mouth and tongue and other discomforts. In addition, the pawpaw can be used for treating symptoms such as edema of lower limbs and the like through the effects of strengthening spleen and stomach, promoting diuresis and eliminating dampness, and has the effects of reducing transaminase, protecting liver, treating hepatitis and removing free radicals in vivo due to rich oleanolic acid content in the pawpaw.
Chinese yam is the most common medicine used in the courtyard, contains rich pituitous protein, vitamins, starch, calcium, polysaccharide, phosphorus, potassium and other nutrients essential to human body, and especially contains 16 kinds of free amino acids required by human body. The Chinese yam is sweet in taste and neutral in nature, enters lung, spleen and kidney channels, is a qi tonifying core medicinal material, is mainly used for treating spleen deficiency diarrhea, consumptive disease cough, diabetes and other symptoms, and has the effects of regulating blood pressure, reducing blood sugar, reducing blood fat and inhibiting tumors. The mucopolysaccharide in rhizoma Dioscoreae has effects of preventing fat deposition on cardiovascular, maintaining elasticity of blood vessel, preventing atherosclerosis, stimulating and regulating immune system, and resisting tumor, virus and aging.
Radix codonopsitis is a tonifying medicinal material, is rich in lobetyolin, atractyloide III, codonopsis pilosula polysaccharide and the like, is often used as a substitute of ginseng, and has the effects of tonifying middle-jiao and Qi, harmonizing stomach and promoting fluid production, and eliminating phlegm and stopping cough. Can be used for treating spleen deficiency, anorexia, loose stool, myasthenia of limbs, palpitation, short breath, dry mouth, and spontaneous perspiration. Is mainly used for treating weakness of spleen and stomach, tiredness and hypodynamia, dry mouth and poor appetite, lung deficiency and dry cough, internal heat and diabetes.
The astragalus is a tonifying medicinal material and is mainly rich in astragalus polysaccharide and astragalus glycoside substances, the ancient books record that the astragalus has the efficacies of strengthening body resistance and consolidating constitution and tonifying middle-jiao energy, and the modern medical research shows that the astragalus contains a large amount of astragalus polysaccharide and has the functions of tonifying spleen and Qi, improving kidney function and improving immunity.
Poria is a fungus medicinal material, mainly contains pachyman, pachymic acid, etc., and also contains potassium, calcium, magnesium, phosphorus, iron, sulfur, silicon dioxide, etc. The pachyman content is very high, and reaches more than 93 percent of the weight of sclerotium. Poria cocos is neutral in nature and sweet and light in taste, and enters heart, lung, spleen and kidney channels, is a very important spleen-tonifying and dampness-removing traditional Chinese medicinal material in traditional Chinese medicinal materials, has the effects of inducing diuresis to alleviate edema, tonifying spleen to stop diarrhea, tonifying heart and spleen, calming heart and tranquilizing mind and enhancing immunity, and is often combined with codonopsis pilosula, bighead atractylodes rhizome, Chinese yam and the like to serve as an adjuvant drug for tonifying lung and spleen and treating qi deficiency.
Atractylodis rhizoma is dried rhizome of Atractylodes macrocephala Koidz of Compositae and is rich in volatile components such as atractylone and atractyloide and rhizoma Atractylodis polysaccharide. It enters spleen and stomach meridians, has good effects of invigorating qi and spleen, and is mainly indicated for qi and spleen deficiency manifested as shortness of breath, lassitude, sallow complexion, loose stool or diarrhea due to spleen deficiency, water-dampness failing to transport, spleen and stomach qi deficiency, abnormal transportation and transformation.
Fructus Amomi, fruit or seed of Zingiberaceae plant, is an aromatic medicinal material commonly used in traditional Chinese medicine, and mainly contains volatile oil, saponins and flavonoids. Fructus Amomi is mainly used for stomach, kidney and spleen, and has effects in promoting qi circulation, regulating stomach function, activating spleen, invigorating stomach, resolving food stagnation, clearing phlegm, moistening lung, promoting bile flow, relieving inflammation, and relieving pain.
Herba Agastaches contains volatile oil components, mainly including patchouli alcohol, eugenol, etc. Has effects in expelling pathogenic wind, dispelling cold, eliminating dampness, inducing perspiration, relieving exterior syndrome, relieving summer-heat, inhibiting bacteria, and relieving inflammation. According to the records of the materia medica, perilla leaf has the functions of dispersing cold and dampness, summer-heat and dampness, stagnated heat and damp-heat, treating exogenous cold pathogen, drinking and eating cold and damp stagnation, resolving dampness and arresting vomiting, promoting qi circulation and relieving pain.
Vitamin E is an effective immunomodulator, and can promote development and cell differentiation of immune organs of organisms, and improve cellular immunity and humoral immunity of the organisms.
Vitamin C is an important immunomodulator, participates in the synthesis process of antibodies, promotes the generation of interferon in organisms, and improves the activity of white blood cells with phagocytic function.
Taurine is a sulfur-containing amino acid with a simple structure in an animal body, and has a chemical name of 2-aminoethanesulfonic acid. Taurine is an active substance for regulating normal physiological activities of organisms, and has a wide range of biological functions of diminishing inflammation, easing pain, maintaining the osmotic pressure balance of the organisms, maintaining the normal visual function, regulating the calcium balance of cells, reducing blood sugar, regulating nerve conduction, participating in endocrine activities, regulating lipid digestion and absorption, increasing the heart contractility, improving the immunity of the organisms, enhancing the oxidation resistance of cell membranes, protecting cardiac muscle cells and the like.
The invention has the beneficial effects that:
(1) the Coicis semen extract contains protein, fat, starch, various amino acids, coixol, triterpenoid, trace elements, etc., has effects of invigorating spleen, promoting diuresis, eliminating dampness, clearing heat, expelling pus, and treating diseases caused by excessive dampness, such as obesity, and difficulty in movement and pain of muscle and joint.
(2) The phaseolus calcaratus extract contains more nutrient substances such as protein, dietary fiber, vitamin A, vitamin E, potassium, magnesium, phosphorus and the like, has the effects of eliminating dampness and tonifying spleen, has the established effects of tonifying spleen and eliminating dampness for people with weakness of spleen and stomach, and also has the effects of relieving summer heat, removing heat toxin, invigorating stomach, relaxing bowel, reducing blood fat, regulating blood sugar, building body and losing weight and the like.
(3) The pawpaw mainly contains triterpenes, organic acids, flavonoids, polysaccharides and other active ingredients. The pawpaw is warm in nature, has the effects of dredging channels and activating collaterals, removing arthralgia and relieving pain, and resolving dampness and removing turbidity, and is suitable for removing summer heat and dampness in summer and treating diseases such as joint ache, channel spasm, neck pain and the like caused by excessive dampness. The mucopolysaccharide in rhizoma Dioscoreae has effects of preventing fat deposition on cardiovascular, maintaining elasticity of blood vessel, preventing atherosclerosis, stimulating and regulating immune system, and resisting tumor, virus and aging.
(4) Fructus Amomi is mainly used for stomach, kidney and spleen, and has effects in promoting qi circulation, regulating stomach function, activating spleen, invigorating stomach, resolving food stagnation, clearing phlegm, moistening lung, promoting bile flow, relieving inflammation, and relieving pain. Vitamin E is an effective immunomodulator, and can promote development and cell differentiation of immune organs of organisms, and improve cellular immunity and humoral immunity of the organisms. Taurine is an active substance for regulating normal physiological activities of organisms, and has a wide range of biological functions of diminishing inflammation, easing pain, maintaining the osmotic pressure balance of the organisms, maintaining the normal visual function, regulating the calcium balance of cells, reducing blood sugar, regulating nerve conduction, participating in endocrine activities, regulating lipid digestion and absorption, increasing the heart contractility, improving the immunity of the organisms, enhancing the oxidation resistance of cell membranes, protecting cardiac muscle cells and the like.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the coix seed and codonopsis pilosula composition for tonifying spleen and clearing damp comprises the following raw materials in parts by weight: 5 parts of coix seed extract, 20 parts of phaseolus calcaratus extract, 5 parts of pawpaw extract, 20 parts of Chinese yam extract, 4 parts of bighead atractylodes rhizome extract, 30 parts of codonopsis pilosula extract, 15 parts of astragalus root extract, 12 parts of poria cocos extract, 4 parts of wrinkled gianthyssop herb extract, 12 parts of fructus amomi extract, 0.01 part of vitamin C, 0.005 part of vitamin E and 0.01 part of taurine.
Wherein, the preparation method of the mixed extract consisting of the coix seed extract, the phaseolus calcaratus extract, the pawpaw extract, the Chinese yam extract and the white atractylodes rhizome extract comprises the following steps:
the method comprises the following steps: weighing 5 parts of coix seed, 20 parts of phaseolus calcaratus, 5 parts of pawpaw, 20 parts of Chinese yam and 4 parts of bighead atractylodes rhizome according to parts by weight, selecting, cleaning, drying, crushing into 10-30-mesh coarse powder, and mixing for later use;
step two: adding water into the mixed coarse powder obtained in the step one, and extracting twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under reflux, and taking primary filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 1:8, extracting under reflux for 1.5h, taking secondary filtrate, combining the two filtrates, and mixing uniformly to obtain mixed extract;
step three: taking the mixed extracting solution obtained in the step two, concentrating the mixed extracting solution under reduced pressure until the relative density is 1.0-1.08, and mixing the extracting solutions according to the weight ratio M: adding maltodextrin into the mixture with the ratio of M to maltodextrin being 1:0.1, and spray drying at the conditions of air inlet temperature of 165 ℃, air outlet temperature of 90 ℃ and tower internal pressure of-35 Pa to obtain the mixed extract.
The preparation method of the freeze-dried powder comprising the ageratum extract and the amomum fruit extract, such as amomum fruit, and the like, comprises the following steps:
the method comprises the following steps: weighing 4 parts of wrinkled gianthyssop herb and 12 parts of fructus amomi according to parts by weight;
step two: cleaning, drying, pulverizing into 0.2cm small pieces, and mixing;
step three: according to mass ratio M mixture: adding 95% ethanol into the mixture at a ratio of 1:8, extracting at 50 deg.C for 12h, filtering, removing residue, concentrating the ethanol extractive solution under reduced pressure, recovering ethanol, and lyophilizing to obtain lyophilized powder of fructus Amomi, etc.
A preparation method of a coix seed and codonopsis pilosula composition for eliminating dampness and tonifying qi of a spleen comprises the following steps:
(1) weighing 30 parts of astragalus, 15 parts of codonopsis pilosula and 12 parts of poria cocos according to parts by weight, cutting into small fragments of 0.2cm, and mixing for later use;
(2) adding 10 times of water into the small fragments obtained in the step (1), heating, boiling and extracting for 2 times, each time for 2 hours, and combining the two extracting solutions;
(3) concentrating and evaporating the extracting solution obtained in the step (2) until the specific gravity d is 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol into the precipitate, washing, and drying under reduced pressure to obtain crude polysaccharide extract of radix Codonopsis and radix astragali;
(4) weighing the rest raw materials according to the formula proportion, mixing the rest raw materials, the mixed extract, the freeze-dried powder of fructus amomi and the like and the crude polysaccharide extract of codonopsis pilosula and astragalus, uniformly mixing, and granulating to obtain the medicine.
Example 2:
the coix seed and codonopsis pilosula composition for tonifying spleen and clearing damp comprises the following raw materials in parts by weight: 20 parts of coix seed extract, 5 parts of phaseolus calcaratus extract, 20 parts of pawpaw extract, 5 parts of Chinese yam extract, 12 parts of bighead atractylodes rhizome extract, 15 parts of codonopsis pilosula extract, 30 parts of astragalus root extract, 4 parts of poria cocos extract, 12 parts of wrinkled gianthyssop herb extract, 4 parts of fructus amomi extract, 0.05 part of vitamin C, 0.001 part of vitamin E and 0.05 part of taurine.
Wherein, the preparation method of the mixed extract consisting of the coix seed extract, the phaseolus calcaratus extract, the pawpaw extract, the Chinese yam extract and the white atractylodes rhizome extract comprises the following steps:
the method comprises the following steps: weighing 20 parts of coix seed, 5 parts of phaseolus calcaratus, 20 parts of pawpaw, 5 parts of Chinese yam and 12 parts of bighead atractylodes rhizome according to parts by weight, selecting, cleaning, drying, crushing into 10-30-mesh coarse powder, and mixing for later use;
step two: adding water into the mixed coarse powder obtained in the step one, and extracting twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under reflux, and taking primary filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 1:8, extracting under reflux for 1.5h, taking secondary filtrate, combining the two filtrates, and mixing uniformly to obtain mixed extract;
step three: taking the mixed extracting solution obtained in the step two, concentrating the mixed extracting solution under reduced pressure until the relative density is 1.0-1.08, and mixing the extracting solutions according to the weight ratio M: adding maltodextrin into the M maltodextrin (1: 0.1), and spray drying at air inlet temperature of 175 deg.C, air outlet temperature of 80 deg.C and tower internal pressure of-40 Pa to obtain mixed extract.
The preparation method of the freeze-dried powder comprising the ageratum extract and the amomum fruit extract, such as amomum fruit, and the like, comprises the following steps:
the method comprises the following steps: weighing 12 parts of wrinkled gianthyssop herb and 4 parts of fructus amomi according to the parts by weight;
step two: cleaning, oven drying, pulverizing into 0.2-0.5cm pieces, and mixing;
step three: according to mass ratio M mixture: adding 95% ethanol into the mixture at a ratio of 1:8, extracting at 50 deg.C for 12h, filtering, removing residue, concentrating the ethanol extractive solution under reduced pressure, recovering ethanol, and lyophilizing to obtain lyophilized powder of fructus Amomi, etc.
A preparation method of a coix seed and codonopsis pilosula composition for invigorating spleen and eliminating dampness comprises the following steps:
(1) weighing 15 parts of astragalus, 30 parts of codonopsis pilosula and 4 parts of poria cocos according to parts by weight, cutting into small fragments of 0.5cm, and mixing for later use;
(2) adding 10 times of water into the small fragments obtained in the step (1), heating, boiling and extracting for 2 times, each time for 2 hours, and combining the two extracting solutions;
(3) concentrating and evaporating the extracting solution obtained in the step (2) until the specific gravity d is 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol into the precipitate, washing, and drying under reduced pressure to obtain crude polysaccharide extract of radix Codonopsis and radix astragali;
(4) weighing the rest raw materials according to the formula proportion, mixing the rest raw materials, the mixed extract, the freeze-dried powder of fructus amomi and the like and the crude polysaccharide extract of codonopsis pilosula and astragalus, uniformly mixing, and granulating to obtain the medicine.
Example 3:
the coix seed and codonopsis pilosula composition for tonifying spleen and clearing damp comprises the following raw materials in parts by weight: 10 parts of coix seed extract, 10 parts of phaseolus calcaratus extract, 15 parts of pawpaw extract, 15 parts of Chinese yam extract, 5 parts of bighead atractylodes rhizome extract, 20 parts of codonopsis pilosula extract, 25 parts of astragalus extract, 5 parts of poria cocos extract, 5 parts of wrinkled gianthyssop extract, 5 parts of fructus amomi extract, 0.03 part of vitamin C, 0.002 part of vitamin E and 0.01 part of taurine.
Wherein, the preparation method of the mixed extract consisting of the coix seed extract, the phaseolus calcaratus extract, the pawpaw extract, the Chinese yam extract and the white atractylodes rhizome extract comprises the following steps:
the method comprises the following steps: weighing 10 parts of coix seed, 10 parts of phaseolus calcaratus, 15 parts of pawpaw, 15 parts of Chinese yam and 5 parts of bighead atractylodes rhizome according to parts by weight, selecting, cleaning, drying, crushing into 10-30-mesh coarse powder, and mixing for later use;
step two: adding water into the mixed coarse powder obtained in the step one, and extracting twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under reflux, and taking primary filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 1:8, extracting under reflux for 1.5h, taking secondary filtrate, combining the two filtrates, and mixing uniformly to obtain mixed extract;
step three: taking the mixed extracting solution obtained in the step two, concentrating the mixed extracting solution under reduced pressure until the relative density is 1.0-1.08, and mixing the extracting solutions according to the weight ratio M: adding maltodextrin into the mixture with the ratio of M to maltodextrin being 1:0.1, and spray drying at the conditions of air inlet temperature of 165 ℃, air outlet temperature of 90 ℃ and tower internal pressure of-35 Pa to obtain the mixed extract.
The preparation method of the freeze-dried powder comprising the ageratum extract and the amomum fruit extract, such as amomum fruit, and the like, comprises the following steps:
the method comprises the following steps: weighing 5 parts of wrinkled gianthyssop herb and 5 parts of fructus amomi according to parts by weight;
step two: cleaning, oven drying, pulverizing into 0.5cm small pieces, and mixing;
step three: according to mass ratio M mixture: adding 95% ethanol into M ethanol 1:8, extracting at 40 deg.C for 12 hr, filtering, removing residue, concentrating the ethanol extractive solution under reduced pressure, recovering ethanol, and lyophilizing to obtain lyophilized powder of fructus Amomi.
A preparation method of a coix seed and codonopsis pilosula composition for invigorating spleen and eliminating dampness comprises the following steps:
(1) weighing 25 parts of astragalus, 20 parts of codonopsis pilosula and 5 parts of poria cocos according to parts by weight, cutting into small fragments of 0.5cm, and mixing for later use;
(2) adding 10 times of water into the small fragments obtained in the step (1), heating, boiling and extracting for 2 times, each time for 2 hours, and combining the two extracting solutions;
(3) concentrating and evaporating the extracting solution obtained in the step (2) until the specific gravity d is 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol into the precipitate, washing, and drying under reduced pressure to obtain crude polysaccharide extract of radix Codonopsis and radix astragali;
(4) weighing the rest raw materials according to the formula proportion, mixing the rest raw materials, the mixed extract, the freeze-dried powder of fructus amomi and the like and the crude polysaccharide extract of codonopsis pilosula and astragalus, uniformly mixing, and granulating to obtain the medicine.
Example 4:
the coix seed and codonopsis pilosula composition for tonifying spleen and clearing damp comprises the following raw materials in parts by weight: 15 parts of coix seed extract, 15 parts of phaseolus calcaratus extract, 10 parts of pawpaw extract, 10 parts of Chinese yam extract, 10 parts of bighead atractylodes rhizome extract, 25 parts of codonopsis pilosula extract, 20 parts of astragalus extract, 5 parts of poria cocos extract, 10 parts of wrinkled gianthyssop extract, 10 parts of fructus amomi extract, 0.01 part of vitamin C, 0.001 part of vitamin E and 0.03 part of taurine.
Wherein, the preparation method of the mixed extract consisting of the coix seed extract, the phaseolus calcaratus extract, the pawpaw extract, the Chinese yam extract and the white atractylodes rhizome extract comprises the following steps:
the method comprises the following steps: weighing 15 parts of coix seed, 15 parts of phaseolus calcaratus, 10 parts of pawpaw, 10 parts of Chinese yam and 10 parts of bighead atractylodes rhizome according to parts by weight, selecting, cleaning, drying, crushing into 10-30-mesh coarse powder, and mixing for later use;
step two: adding water into the mixed coarse powder obtained in the step one, and extracting twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under reflux, and taking primary filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 1:8, extracting under reflux for 1.5h, taking secondary filtrate, combining the two filtrates, and mixing uniformly to obtain mixed extract;
step three: taking the mixed extracting solution obtained in the step two, concentrating the mixed extracting solution under reduced pressure until the relative density is 1.0-1.08, and mixing the extracting solutions according to the weight ratio M: adding maltodextrin into the M maltodextrin (1: 0.1), and spray drying at air inlet temperature of 175 deg.C, air outlet temperature of 80 deg.C and tower internal pressure of-40 Pa to obtain mixed extract.
The preparation method of the freeze-dried powder comprising the ageratum extract and the amomum fruit extract, such as amomum fruit, and the like, comprises the following steps:
the method comprises the following steps: weighing 5 parts of wrinkled gianthyssop herb and 10 parts of fructus amomi according to parts by weight;
step two: cleaning, drying, pulverizing into 0.2cm small pieces, and mixing;
step three: according to mass ratio M mixture: adding 95% ethanol into the mixture at a ratio of 1:8, extracting at 50 deg.C for 12h, filtering, removing residue, concentrating the ethanol extractive solution under reduced pressure, recovering ethanol, and lyophilizing to obtain lyophilized powder of fructus Amomi, etc.
A preparation method of a coix seed and codonopsis pilosula composition for invigorating spleen and eliminating dampness comprises the following steps:
(1) weighing 20 parts of astragalus, 25 parts of codonopsis pilosula and 5 parts of poria cocos according to parts by weight, cutting into small fragments of 0.2cm, and mixing for later use;
(2) adding 10 times of water into the small fragments obtained in the step (1), heating, boiling and extracting for 2 times, each time for 2 hours, and combining the two extracting solutions;
(3) concentrating and evaporating the extracting solution obtained in the step (2) until the specific gravity d is 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol into the precipitate, washing, and drying under reduced pressure to obtain crude polysaccharide extract of radix Codonopsis and radix astragali;
(4) weighing the rest raw materials according to the formula proportion, mixing the rest raw materials, the mixed extract, the freeze-dried powder of fructus amomi and the like and the crude polysaccharide extract of codonopsis pilosula and astragalus, uniformly mixing, and granulating to obtain the medicine.
According to statistics of clinical curative effect observation test examples, the curative effect of the coix seed and codonopsis pilosula composition provided by the invention in treating rheumatism is compared with the pharmaceutical composition for treating rheumatism provided by the prior art, and the curative effect result is shown in table 1.
The curative effect standard is as follows:
and (3) curing: arthralgia, fever, fear of cold, swelling, inability to bend and stretch, lumbago and other symptoms disappear.
Improvement: occasionally related to symptoms such as arthralgia, fever, lumbago, etc., fear of cold, swelling phenomenon disappears, and the patient can bend and stretch.
And (4) invalidation: arthralgia, fever, fear of cold, swelling, inability to bend and stretch, lumbago and other symptoms are not improved.
TABLE 1
| Group of | Case/person | Period/day | Cure of disease | Improvement of life | Invalidation | High efficiency |
| Example 1 | 50 | 14 days | 43 | 6 | 1 | 98％ |
| Example 2 | 50 | 14 days | 44 | 5 | 1 | 98％ |
| Example 3 | 50 | 14 days | 44 | 4 | 2 | 96％ |
| Example 4 | 50 | 14 days | 43 | 5 | 2 | 96％ |
| Prior Art | 50 | 14 days | 35 | 5 | 10 | 80％ |
As can be seen from table 1, compared with the pharmaceutical composition for treating rheumatism provided by the prior art, the composition of coix seed and codonopsis pilosula provided by the embodiment of the invention has higher cure rate and better curative effect.
Typical case 1: wu women, 41 years old, have rheumatoid 2 years old, take medicines (the medicines for treating rheumatism that the prior art provides) all the time, often repeatedly, can't cure completely, formulate the medicament of the invention according to example 1, after taking 1 course, the symptom is obviously relieved, continue taking 2 courses, have no obvious painful sensation, consolidate taking 2 courses, cure completely, visit 1 year without recurrence.
Typical case 2: when the patient is in a certain season, 50 years old, suffering from lumbago and backache rheumatism with intolerable pain, limb numbness and soreness, even unable to live normally, the patient takes the medicine (the medicine for treating rheumatism provided by the prior art) all the time, the medicine is prepared according to the embodiment 2, after taking 2 courses of treatment, the soreness is relieved, the numbness of limbs disappears, and the patient can be healed after continuing taking 2 courses of treatment, so far, no recurrence exists.
Typical case 3: wangzhi, women, age 45, suffered from rheumatism for 3 years, during which the pain of the joints of the whole body is aggravated in cold days, the pain of the joints of the whole body appears, the movement is obviously limited, the patients cannot sit for a long time and squat, and the patients feel difficult to walk, the medicines (the medicines for treating the rheumatism provided by the prior art) are taken all the time, the multi-party treatment is ineffective, the medicine is prepared according to the embodiment 3, after 1 course of taking, the symptoms are obviously improved, after 1 course of continuing taking, the patients are cured, and then the patients are firmly taken for 2 courses of treatment, so that the diseases are not relapsed at present.
Typical case 4: in 54 years old of the week, the patients with arthralgia, fever, fear of cold, swelling and incapability of flexing and extending are all taken, the medicine (the medicine for treating rheumatism provided by the prior art) is prepared according to the example 4, after the medicine is taken for 2 treatment courses, the symptoms of arthralgia, fever, fear of cold, swelling, incapability of flexing and extending disappear, and the patients are healed after the medicine is continuously taken for 2 treatment courses until now, no relapse occurs.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (6)
1. The coix seed and codonopsis pilosula composition for invigorating spleen and eliminating dampness is characterized by comprising the following raw materials in parts by weight: 5-20 parts of coix seed extract, 5-20 parts of phaseolus calcaratus extract, 5-20 parts of pawpaw extract, 5-20 parts of Chinese yam extract, 4-12 parts of bighead atractylodes rhizome extract, 15-30 parts of codonopsis pilosula extract, 15-30 parts of astragalus extract, 4-12 parts of poria cocos extract, 4-12 parts of wrinkled gianthyssop extract, 4-12 parts of fructus amomi extract, 0.01-0.05 part of vitamin C, 0.001-0.005 part of vitamin E and 0.01-0.05 part of taurine.
2. The coix seed and codonopsis pilosula composition for invigorating spleen and eliminating dampness according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 10-15 parts of coix seed extract, 10-15 parts of phaseolus calcaratus extract, 10-15 parts of pawpaw extract, 10-15 parts of Chinese yam extract, 5-10 parts of bighead atractylodes rhizome extract, 20-25 parts of codonopsis pilosula extract, 20-25 parts of astragalus extract, 5-10 parts of poria cocos extract, 5-10 parts of wrinkled gianthyssop extract, 5-10 parts of fructus amomi extract, 0.01-0.03 part of vitamin C, 0.001-0.002 part of vitamin E and 0.01-0.03 part of taurine.
3. The composition of coix seed and codonopsis pilosula for invigorating spleen and eliminating dampness as claimed in claim 2, wherein the preparation method of the mixed extract consisting of the coix seed extract, the phaseolus calcaratus extract, the pawpaw extract, the Chinese yam extract and the bighead atractylodes rhizome extract comprises the following steps:
the method comprises the following steps: weighing 10-15 parts of coix seed, 10-15 parts of phaseolus calcaratus, 10-15 parts of pawpaw, 10-15 parts of Chinese yam and 5-10 parts of bighead atractylodes rhizome according to parts by weight, selecting, cleaning, drying, crushing into 10-30-mesh coarse powder, and mixing for later use;
step two: adding water into the mixed coarse powder obtained in the step one, and extracting twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under reflux, and taking primary filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 1:8, extracting under reflux for 1.5h, taking secondary filtrate, combining the two filtrates, and mixing uniformly to obtain mixed extract;
step three: taking the mixed extracting solution obtained in the step two, concentrating the mixed extracting solution under reduced pressure until the relative density is 1.0-1.08, and mixing the extracting solutions according to the weight ratio M: adding maltodextrin into the M maltodextrin (1: 0.1), and spray drying to obtain mixed extract.
4. The composition of coix seed and codonopsis pilosula for invigorating spleen and eliminating dampness as claimed in claim 3, wherein the spray drying conditions in the third step are that the air inlet temperature is 165-175 ℃, the air outlet temperature is 80-90 ℃, and the pressure in the tower is-35 to-40 Pa.
5. The coix seed and codonopsis pilosula composition for invigorating spleen and eliminating dampness as claimed in claim 2, wherein the preparation method of the fructus amomi freeze-dried powder comprising the agastache rugosus extract and the fructus amomi extract comprises the following steps:
the method comprises the following steps: weighing 5-10 parts of wrinkled gianthyssop herb and 5-10 parts of fructus amomi according to parts by weight;
step two: cleaning, oven drying, pulverizing into 0.2-0.5cm pieces, and mixing;
step three: according to mass ratio M mixture: adding 95% ethanol into the mixture at a ratio of 1:8, leaching for 12h at 40-50 ℃, filtering, removing filter residue, concentrating the ethanol extract under reduced pressure, recovering ethanol, and freeze-drying to obtain freeze-dried powder of fructus Amomi and the like.
6. A method for preparing the coix seed and codonopsis pilosula composition for tonifying spleen and eliminating dampness according to any one of claims 1 to 5, which is characterized by comprising the following steps:
(1) weighing 20-25 parts of astragalus, 20-25 parts of codonopsis pilosula and 5-10 parts of poria cocos according to parts by weight, cutting into small fragments of 0.2-0.5cm, and mixing for later use;
(2) adding 10 times of water into the small fragments obtained in the step (1), heating, boiling and extracting for 2 times, each time for 2 hours, and combining the two extracting solutions;
(3) concentrating and evaporating the extracting solution obtained in the step (2) until the specific gravity d is 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol into the precipitate, washing, and drying under reduced pressure to obtain crude polysaccharide extract of radix Codonopsis and radix astragali;
(4) weighing the rest raw materials according to the formula proportion, mixing the rest raw materials, the mixed extract, the freeze-dried powder of fructus amomi and the like and the crude polysaccharide extract of codonopsis pilosula and astragalus, uniformly mixing, and granulating to obtain the medicine.
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| CN113384539A (en) * | 2021-06-22 | 2021-09-14 | 安徽三义堂中药饮片有限公司 | Granular tea for tonifying spleen and kidney and removing dampness and preparation method thereof |
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Application publication date: 20210330 |