CN111588029A - Polygonatum sibiricum paste composition - Google Patents
Polygonatum sibiricum paste composition Download PDFInfo
- Publication number
- CN111588029A CN111588029A CN202010467010.1A CN202010467010A CN111588029A CN 111588029 A CN111588029 A CN 111588029A CN 202010467010 A CN202010467010 A CN 202010467010A CN 111588029 A CN111588029 A CN 111588029A
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- China
- Prior art keywords
- parts
- paste
- rhizoma polygonati
- prepared
- powder
- Prior art date
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- Pending
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention provides a polygonatum sibiricum paste composition which is prepared from the following raw materials in parts by weight: 48-60 parts of rhizoma polygonati, 8-10 parts of white poria, 8-10 parts of pine pollen, 8-10 parts of cordyceps militaris, 8-10 parts of wolfberry fruit and 10-15 parts of xylitol. The polygonatum sibiricum paste composition provided by the invention is easy to digest and absorb, has the effects of protecting a cardiovascular system, tonifying kidney and replenishing vital essence, nourishing yin and moistening dryness, resisting aging and prolonging life, and increases the health care value.
Description
Technical Field
The invention relates to the field of health-care food compositions, in particular to a polygonatum paste composition.
Background
Rhizoma Polygonati is perennial herb of Polygonatum of Liliaceae, and has rhizoma Polygonati, Polygonatum kingianum, Polygonatum cyrtonema and the like as main species, and dried rhizome thereof is used as medicine. According to the traditional medicine classical record, the sealwort belongs to a rare traditional Chinese medicine and has the effects of strengthening the middle-jiao, tonifying qi, tonifying the kidney, replenishing essence, nourishing yin, moistening the lung, promoting the production of body fluid and tonifying the spleen. It can be used for treating dry cough due to lung dryness, asthenia, palpitation, short breath, xerostomia due to body fluid deficiency, diabetes, and hypertension. Has good effects on treating cardiovascular diseases, tuberculosis and chronic hepatitis, and has the effects of resisting bacteria, detoxifying, resisting fatigue, resisting aging, reducing blood sugar, reducing blood fat, resisting tumors and the like.
In recent years, the research on polygonatum plants is intensive, and a lot of chemical components are separated from the polygonatum plants: polysaccharide, steroid saponin, flavone, etc., wherein the polysaccharide has multiple physiological functions, and mainly has effects of reducing blood lipid, resisting atherosclerosis, resisting aging, resisting tumor, enhancing immunity, resisting herpes simplex virus, reducing blood sugar, resisting hypoxic nerve cell necrosis and apoptosis, and regulating telomerase activity. Therefore, the sealwort is widely applied to traditional Chinese medicine materials at present.
With the development of social economy and the improvement of living standard of people, the people who suffer from kidney deficiency, premature senility, deficiency of qi and blood, insomnia and dreaminess, cardiovascular diseases and diabetes are increasing due to the gradually increased living pressure, the nourishment of bad living habits or the body factors of the people. The treatment of cardiovascular diseases is to take western medicines for a long time, so that the side effect is large and the diseases cannot be cured radically. There are few products that are preventable in advance. The development of various rhizoma polygonati processed products can provide convenience for preventing the diseases in advance, but the existing rhizoma polygonati paste has the problems of fullness and abdominal distension after being eaten, and the existing rhizoma polygonati paste is greasy and causes dyspepsia.
Disclosure of Invention
The invention aims to provide a polygonatum paste composition, and provides a polygonatum paste which is prepared from polygonatum, has a unique formula, good taste, is suitable for long-term administration, and can prevent cardiovascular diseases, tonify spleen and kidney qi and yin, improve sleep, resist aging and prolong life, aiming at the defects of the existing product.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
a polygonatum sibiricum paste composition is composed of the following raw materials in parts by weight:
48-60 parts of rhizoma polygonati, 8-10 parts of white poria, 8-10 parts of pine pollen, 8-10 parts of cordyceps militaris, 8-10 parts of wolfberry fruit and 10-15 parts of xylitol;
the preparation method of the rhizoma polygonati ointment is elaborately prepared by combining a genuine ancient method procedure with a modern component purification process, and comprises the following steps:
1) soaking: soaking fresh rhizoma Polygonati in selenium-rich water for 12-13 h;
2) steaming and sun drying for nine times: placing the sealwort soaked in the step 1) in a steam box to steam for 40-50min to obtain clinker, then airing the clinker until the water content of the clinker is reduced to 10% -15%, and repeating the steps for nine times to obtain cooked sealwort;
3) crushing: respectively pouring the prepared rhizoma polygonati prepared in the step 2), the processed white poria, the processed cordyceps militaris and the medlar into a traditional Chinese medicine grinding machine for grinding and storing;
4) boiling: mixing rhizoma Polygonati powder, Poria powder, Cordyceps powder, fructus Lycii powder and pollen Pini, adding water, and stirring;
5) boiling: boiling the medicine paste prepared in the step 4) with big fire, and then decocting for 3 hours with small fire;
6) collecting paste, filtering the decocted paste in the step 5) to remove residues, concentrating the paste with strong fire to paste, and finally adding xylitol and stirring the mixture evenly;
7) cooling to obtain the final product.
The sealwort of the invention is sweet and neutral in flavor and enters kidney, spleen and lung meridians. The main components are polygonatum polysaccharide, aspartic acid, homoserine and cardiac glycoside. Has effects in invigorating qi, nourishing yin, invigorating spleen, moistening lung, invigorating kidney, replenishing essence, strengthening tendons and bones, blackening hair, and prolonging life, and can be used for treating diabetes, nephropathy, chronic liver disease, pulmonary tuberculosis, and hyperlipidemia. It has antifatigue, antioxidant and antiviral effects.
Cordyceps militaris is sweet and neutral in flavor, and enters kidney and lung meridians. The main components comprise cordycepin, cordyceps polysaccharide, cordycepic acid and soD, and the content of the cordycepic acid is 89 times higher than that of cordyceps sinensis. Has effects in enhancing immunity, relieving fatigue, resisting aging, resisting anoxia, resisting cancer, and promoting sex hormone-like action. Cordyceps polysaccharide also has effects of resisting blood coagulation, reducing blood sugar, reducing blood lipid, and improving liver function.
The white poria is sweet in taste and mild in nature, and has the main components of pachyman, pachymic acid, lecithin and sterol, and has the functions of resisting toxicity and cancer, promoting diuresis, calming heart and tranquilizing mind, and the white poria is used for heart channel, lung channel, spleen channel and kidney channel. Eliminating dampness and promoting diuresis; strengthening the spleen and stomach; to calm heart and induce tranquilization. Can be used for treating dysuria; edema and fullness; cough with phlegm and fluid retention; vomiting; poor appetite due to spleen deficiency; diarrhea; palpitation and uneasiness; insomnia and amnesia; seminal emission is white and turbid.
Medlar is sweet and neutral in flavor, and enters kidney, liver, spleen and heart meridians. The main components comprise lycium barbarum polysaccharide, amino acid and anthocyanin. Has effects in replenishing vital essence, improving eyesight, nourishing liver and kidney, resisting aging, and caring skin. Has effects in regulating immunity, resisting aging, resisting tumor, relieving fatigue, lowering blood sugar, reducing blood lipid, and lowering blood pressure.
Pollen Pini is sweet and warm in flavor, and enters liver meridian and spleen meridian. The main components comprise 22 amino acids, 15 vitamins, nearly hundred enzymes and 30 trace elements. Has effects of moistening heart and lung, invigorating qi, and inducing resuscitation. Has antiaging, gastrointestinal function promoting, senile dementia preventing, and anticancer effects.
The invention has the beneficial effects that: the polygonatum sibiricum paste composition provided by the invention is easy to digest and absorb, has the effects of protecting a cardiovascular system, tonifying kidney and replenishing vital essence, nourishing yin and moistening dryness, resisting aging and prolonging life, and increases the health care value.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments.
Example one
A polygonatum sibiricum paste composition is prepared from the following raw materials in parts by weight of 6: 1: 1: 1: 1, preparing an ointment by the following steps of, for example, 60g of rhizoma polygonati, 10g of white poria, 10g of pine pollen, 10g of cordyceps militaris and 10g of medlar, and 1) soaking: soaking fresh rhizoma Polygonati in selenium-rich water for 12-13 h;
2) steaming and sun drying for nine times: placing the sealwort soaked in the step 1) in a steam box to steam for 40-50min to obtain clinker, then airing the clinker until the water content of the clinker is reduced to 10% -15%, and repeating the steps for nine times to obtain cooked sealwort;
3) crushing: respectively pouring the prepared rhizoma polygonati prepared in the step 2), the processed white poria, the processed cordyceps militaris and the medlar into a traditional Chinese medicine grinding machine for grinding and storing;
4) boiling: mixing rhizoma Polygonati powder, Poria powder, Cordyceps powder, fructus Lycii powder and pollen Pini, adding water, and stirring;
5) boiling: boiling the medicine paste prepared in the step 4) with big fire, and then decocting for 3 hours with small fire;
6) collecting paste, filtering the decocted paste in the step 5) to remove residues, concentrating the paste with strong fire to paste, adding xylitol and stirring uniformly;
7) cooling to obtain the final product.
And (5) research on immunity enhancing function.
The samples prepared in example one were tested for 30 days in groups of 10 mice of single sex. The experiment that the macrophages of the mice phagocytize the chicken erythrocytes in the first part 1 of the test method for enhancing the immunity function in the technical specification for health food examination and evaluation (2003 edition) is referred to in the specific experimental process and evaluation standard, and the experimental result shows that the phagocytosis rate of the mice fed with the product of the embodiment for 30 days is about 30 percent on average, and the phagocytosis rate of the chicken erythrocytes phagocytized by the macrophages in the abdominal cavity of the mice is obviously increased, which indicates that the compound has the function of promoting the phagocytosis of the phagocytes of the mouse and can enhance the non-specific immunity function of the mouse.
Trial study of the sample
The sample prepared in the first embodiment of the invention is eaten 30g every day, people in the age stage of 20-80 years are randomly selected to eat in a trial mode, tracking observation shows that no fever or cold occurs in 2 years after eating the sample, the skin is obviously ruddy and glossy after taking the sample for 1 year, and the sample is effective in preventing cardiovascular and cerebrovascular diseases, and the specific cases are as follows:
li Shi, 84 years old, men, due to their age, had weak legs and feet, blurred vision, slightly higher hyperlipidemia, occasionally dizziness, and an old face. Paste soup is drunk in 2 months in 2018 till now, paste is drunk for one period (30 days) till now: the stomach and intestine are good, the diet is normal, the legs and feet are obviously powerful, the walking is not tired for 3-5 kilometers in one day, the vision is improved, the visual objects are clear, the three lipids are normal, and the uric acid is normal. The complexion is moist and lustrous, compared with the young face of about 5-10 years old.
Zhangzhi, 77 years old, women, because of the relationship of age, the legs and feet are weak before, knee joint inflammation pain, vision is declined, the face color is slightly palsy, 2018, 4 months, the paste soup is drunk till now in a period (30 days) of combining the hospital medicine to treat knee joint pain and drink the paste soup, the intestines and the stomach are good, the diet is normal, the legs and feet are obviously powerful, the people walk 3-5 kilometers each day easily and not tired, the vision is better, the visual objects are clear, the face color is moist and glossy, and the comparison is carried out before the young 5-10 years old.
The aged man is 60 years old, and due to the increase of working reasons and age, the man often feels soreness and backache at ordinary times, legs and feet are weak, knee joints are bent with sound, eyesight is declined, the face color is old and the man starts to drink the paste soup in 2019 months to the present, after normal work and regular life, the man drinks the paste soup for a period (30 days) till now, the stomach is good, the knee joint sound disappears, the legs and feet are powerful, the waist is not sore and the legs are not tired after walking for 3-5 kilometers every day, the eyesight is recovered to be normal, the face color is moist and glossy, and the old man is younger than the old man by 5-10 years.
For a moustache, 57 years old, men often feel soreness and backache due to work reasons and age, legs and feet are weak, knee joints are bent with sound, eyesight is declined, the face color is slightly dark, uric acid 480 (higher) starts to drink ointment soup in 2018, 4 months, the paste soup is up to now, on the premise of normal work, after a period (30 days) is drunk, the intestines and the stomach are good, the knee joint sound disappears, uric acid 325 (normal), legs and feet are obviously powerful, the waist is not sore and backache, the eyesight is recovered to be normal, the face color is moist and glossy.
For a certain time, 54 years old, men often feel soreness of waist and backache due to the increase of working reasons and ages, legs and feet are weak, knee joints are bent with sound, eyesight is declined, the face color is slightly old, and the men begin to drink the paste soup in 2018 months to the present, on the premise of normal working, after drinking a period (30 days), the intestines and the stomach are good, the knee joint sound disappears, the legs and the feet are obviously powerful, the waist is not sore and backache under the same working time, the eyesight is recovered to be normal, the face color is moist and glossy, and the age is about 5-10 years old before comparison.
Liao, 45 years old, female, Huizhou city, Guangdong province, because the family life difficulty of hour, lead to the weak and sickliness, in addition later job reason and the increase of age, often feel sore back pain at ordinary times, the leg and foot are weak, knee joint has the sound, the eyesight is declined, the face color is slightly pale and old, 2016 is 11 months old and begin to drink the cream soup under the prerequisite of normal work up till now, drink one cycle (30 days) after and till now, the intestines and stomach is good, knee joint sound disappears, the leg and foot is obviously powerful, beat tennis and continue not tired for 3 hours, the eyesight resumes normal, the face color is moist and glossy, compare before about 5-10 years old.
Guo is a disease of 26 years old, and for men, due to working reasons, the tumor disease is caused by long-term staying up all night, 18 times of chemotherapy are carried out in Guangzhou Zhongshan tumor hospital from 10 months in 2017, legs and feet are weak, the vision is blurred, hairs are bare, the appetite is not good, the diet is irregular, and the physique is weak. Paste soup is drunk in 4 months in 2018 till now after one period (30 days) on the premise of combining hospital drug treatment: good intestines and stomach, normal diet, powerful legs and feet, normal vision, dark and luxuriant hair, moist and lustrous face and basically recovered health as before.
Wu-Zhi, age 22, male, because of irregular daily life, usually listlessness, weakness of legs and feet, dislike of exercise, visual deterioration, pale complexion. The paste is drunk in 4 months in 2018, so far, under the combination of regular life and daily life, and after a period (30 days) is drunk, so that the paste is good in intestines and stomach, vigorous in energy, enhanced in physical performance, as early as possible in visual recovery, moist and glossy in face and tender and smooth in skin.
Plum, female, 42 years old, diagnosed as mild hyperlipidemia two years ago, obese constitution, lipid indicators: triglyceride, cholesterol and low density lipoprotein are all obviously increased, after taking the medicine of the invention for 1 year, the blood fat is rechecked, the indexes are all reduced to normal level, the body mass index is up to the standard, the liver and kidney function damage is not seen in blood examination, and the patient has no obvious discomfort after taking the medicine.
The composition takes sealwort as a monarch drug, and the sealwort is the yin of the yin, produced in Hunan province and is new; cordyceps militaris and fructus Lycii are ministerial drugs. The energy of the cordyceps militaris gold acts on the lung and is added to the kidney water, the medlar acts on the liver and is added to the heart fire, and the medlar also assists the kidney and brings out the best in each other with the sealwort; poria is adjuvant drug, acting on spleen and holding in lung; pollen Pini is used as guiding drug. The property of invigorating yang and inducing resuscitation harmonizes five internal organs, so that qi movement of the whole body of a person can be reached up and down, and the cream formula is guaranteed to be soft but not greasy. The ointment is prepared by screening various compositions on the basis of the existing rhizoma polygonati ointment, screening the composition with the best health care effect, and the effect is verified through various tests, so that the problem of dyspepsia caused by sexual and greasy of the existing rhizoma polygonati ointment is greatly improved.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (2)
1. The sealwort paste composition is characterized by comprising the following raw materials in parts by weight:
48-60 parts of rhizoma polygonati, 8-10 parts of white poria, 8-10 parts of pine pollen, 8-10 parts of cordyceps militaris, 8-10 parts of wolfberry fruit and 10-15 parts of xylitol.
2. The polygonatum paste composition according to claim 1, which is prepared by the following steps:
1) soaking: soaking fresh rhizoma Polygonati in selenium-rich water for 12-13 h;
2) steaming and sun drying for nine times: placing the sealwort soaked in the step 1) in a steam box to steam for 40-50min to obtain clinker, then airing the clinker until the water content of the clinker is reduced to 10% -15%, and repeating the steps for nine times to obtain cooked sealwort;
3) crushing: respectively pouring the prepared rhizoma polygonati prepared in the step 2), the processed white poria, the processed cordyceps militaris and the medlar into a traditional Chinese medicine grinding machine for grinding and storing;
4) boiling: mixing rhizoma Polygonati powder, Poria powder, Cordyceps powder, fructus Lycii powder and pollen Pini, adding water, and stirring;
5) boiling: boiling the medicine paste prepared in the step 4) with big fire, and then decocting for 3 hours with small fire;
6) collecting paste, filtering the decocted paste in the step 5) to remove residues, concentrating the paste with strong fire to paste, adding xylitol and stirring uniformly;
7) cooling to obtain the final product.
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CN112841648A (en) * | 2021-01-20 | 2021-05-28 | 云南省农业科学院农产品加工研究所 | Preparation method and application of rhizoma polygonati |
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CN105623984A (en) * | 2014-11-07 | 2016-06-01 | 安徽中医药大学 | Medicinal and edible Yuyou Baxian wine and preparation method thereof |
CN106901264A (en) * | 2016-12-31 | 2017-06-30 | 青阳县禅悦食品工贸有限公司 | A kind of nine turns of rhizoma polygonati creams and preparation method thereof |
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