CN103099833A - Soft capsule helpful for relieving sports fatigue and delaying aging and preparation method thereof - Google Patents
Soft capsule helpful for relieving sports fatigue and delaying aging and preparation method thereof Download PDFInfo
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Abstract
The invention mainly relates to a soft capsule helpful for relieving sports fatigue and delaying aging. The soft capsule helpful for relieving the sports fatigue and delaying the aging is characterized by consisting of the following raw materials in parts by weight: 360-540 parts of linseed oil, 10-30 parts of wapiti velvet antler freeze-dried powder, 10-30 parts of a ginseng ground material, 10-30 parts of a dried rehmannia root extract, 10-30 parts of a rhizoma polygonati extract, 10-30 parts of a tuckahoe extract and 10-30 parts of a horny goat weed extract. The soft capsule is added with natural components capable of relieving the sports fatigue and delaying the aging, so that the component functions as invigorating kidney and strengthening Yang, strengthening tendons and bones, tonifying Qi and nourishing Yin, and integrally improving physical function, and circulations of Qi and blood are smooth, and nutrition is sufficient. Wapiti velvet antler and horny goat weed are capable of invigorating kidney and strengthening Yang, and strengthening tendons and bones; ginseng is capable of tonifying Qi and nourishing Yin, and clearing away heat and promoting secretion of saliva; rhizoma polygonati can moisten lung and nourish Yin, strengthen spleen and tonify Qi; tuckahoe is favorable for clearing damp and promoting diuresis, tonifying spleen and calming; dried rehmannia root functions as clearing away heat and cooling blood, nourishing Yin and promoting secretion of saliva; and linseed oil has functions of preventing and treating cancers, coronary heart disease, diabetes, prostatic cancer and other diseases. The composition integrally improves physical condition, relieves the sports fatigue and delays the aging.
Description
Technical field:
The present invention relates generally to soft capsule that helps relieving sports fatigue and slow down aging and preparation method thereof.
Background technology:
At present, help the formula of relieving sports fatigue and slow down aging, existing relevant report.The object of the invention is to avoid the deficiencies in the prior art part:
1, prior art adopts the single raw material to realize health care more, and larger negative interaction can appear in this health food informal dress, and the property of medicine is wandered off, and attends to one thing and lose sight of another.The present invention adopts compound recipe form prescription, fully takes into account whole structure, pursues cool thermal balance, equilibrium between yin and yang, property of medicine complementation, both aided suitable, again mutually the restriction, take rear safer more effective, long-term use without side effects is as: Cornu Cervi Pantotrichum in the side, Herba Epimedii is warm in nature and dry; Yin nourishing function with Radix Rehmanniae, Rhizoma Polygonati, Radix Panacis Quinquefolii in formula is restricted, but the resisting fatigue, anti-senescence function of temperature, cool two class Chinese medicines are strengthened.In the side, Cornu Cervi Pantotrichum has the effect that rises blood pressure, but Herba Epimedii etc. have hypotensive effect, mutually restriction; The expansible blood capillary of Cornu Cervi Pantotrichum; Radix Rehmanniae hemostasis etc.Compatibility integral body has been strengthened resisting fatigue, senile-resistant efficacy, but has reduced side effect, makes preparation allomeric function balance, not dry not cool, is suitable for long-term taking.
2, existing formula seldom has the health food take Cornu Cervi Pantotrichum as raw material, and various Chinese medicine ancient books and modern study have confirmed that Cornu Cervi Pantotrichum is best resisting fatigue, antidotal medicine in fact, uses as food additive in Korea S, is used for child and old people.Wherein amino acid content is more than 50%, and is best in quality, contains the necessary mineral of various human bodies and trace element, and the various active somatomedin is arranged, and can repair the human body athletic injury, and the Herba Epimedii compatibility can strengthen bone density.Can improve mental status, strengthen elasticity and the intensity of muscle, promote wound healing.
3, existing formula is main mainly with hard capsule, easily oxidation deterioration, and easily fraud; And the present invention adopts soft capsule dosage form, and packing is tight and extraneous thoroughly isolated, can effectively prevent the content oxidation deterioration, and taking convenience, easily absorbs the high-grade fashion of dosage form.
4, existing health food soft capsule content is main mainly with the ground product of crude drug, and the content volume is large, but active constituent content is low, takes rear effect relatively poor; And the present invention is ground product except Cornu Cervi Pantotrichum, Radix Panacis Quinquefolii, and all the other are extract, and volume is little, content is abundant, the health care component content is high, takes rear effect remarkable.
5, existing soft capsule preparation is considered the effect of solute more, and solvent selects salad oil to ignore the effect of solvent and soft gel coat; And in this formula take siritch as solvent, contain very high alpha-linolenic acid in siritch; Take bone collagen as capsule shells, fully take into account the efficacy effect of each ingredient of soft capsule, make the product efficacy multiplication, get twice the result with half the effort.
Summary of the invention:
The object of the invention is to avoid the deficiencies in the prior art part and a kind of soft capsule that helps relieving sports fatigue and slow down aging and preparation method thereof is provided, the problem that exists to solve prior art.
Purpose of the present invention can be by realizing by the following technical solutions: a kind of soft capsule that helps relieving sports fatigue and slow down aging, its main feature are the raw materials that includes following weight portion: siritch 360-540 weight portion, cervus elaphus linnaeus lyophilized powder 10-30 weight portion, the Radix Panacis Quinquefolii powder 10-30 weight portion that minces;
The described soft capsule that helps relieving sports fatigue and slow down aging also includes the raw material of following weight portion: Rhizoma Polygonati extract 10-30 weight portion, Radix Rehmanniae extract 10-30 weight portion, Herba Epimedii extract 10-30 weight portion;
The described soft capsule that helps relieving sports fatigue and slow down aging also includes the raw material of following weight portion: Poria extract 10-30 weight portion
A kind of preparation method that helps the soft capsule of relieving sports fatigue and slow down aging, its main feature is, comprises the steps:
(1) raw material preparation
Rhizoma Polygonati, Radix Rehmanniae, Poria, Herba Epimedii are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, lixiviate 2-8 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.
Radix Panacis Quinquefolii is pulverized, and granularity is 0.1-0.5mm.
The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch.
Cervus elaphus linnaeus: (20)-(25) ℃ freezing cervus elaphus linnaeus, section, lyophilization, dried cervus elaphus linnaeus is pulverized, the granularity of sieving is 0.1-0.5mm, is the cervus elaphus linnaeus powder.
(2) with siritch, the raw materials such as cervus elaphus linnaeus, Radix Panacis Quinquefolii, Rhizoma Polygonati, Radix Rehmanniae, Poria, Herba Epimedii mix in proportion.
(3) press 0.6g/ grain dress soft capsule after mix homogeneously.
(4) sterilization bottling, vanning.
1, the invention has the beneficial effects as follows: the method screening raw material that our section of use emulates the advanced, rigorous prescription, the check of the various raw materials of process and chemical analysis thereof, function, the total analysis result of the present invention of cash is as follows:
(1) cervus elaphus linnaeus
Kidney-Yang invigorating fills blood, beneficial marrow, bone and muscle strengthening.Control the asthenia weakness and emaciation, spirit is tired weary, dizzy, deafness, and order is dark, soreness of waist and knee joint, sexual impotence, spermatorrhea; Deficiency-cold of uterus, metrorrhagia, leukorrhagia.
The effect of cervus elaphus linnaeus:
1. strong effect.It can improve the ability to work of body, improves sleep and diet, reduces tired.
2. to cardiovascular effect.The pantocrine heavy dose can make blood pressure drops, decreased heart rate, peripheral blood vessel expansion; Median dose can make contractile force strengthen, and heart rate is accelerated, and cardiac output increases, and weak heart is had obvious cardiotonic.Arrhythmia there is regulating action, and heart contraction is strengthened.
3. gonadotropic Effect is arranged.Animal experiment confirms, makes subcutaneous injection with the Cornu Cervi Pantotrichum tincture, sees namely after several days that prostate, seminal vesicle weight increase.
4. its can excited intestine in vitro and uterus, strengthens the diuresis function of kidney.
(2) Radix Rehmanniae:
Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch., has another name called Radix Rehmanniae, and nature and flavor are sweet, bitter, cold, has the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, is heat removing and blood cooling medicine.Radix Rehmanniae is widely used in modern health product etc. due to its magical curative effect.
The effect of Radix Rehmanniae: Radix Rehmanniae clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis.Be used for consumption of YIN caused by febrile disease, the crimson tongue excessive thirst is sent out the speckle dermexanthesis, spit blood, and epistaxis, laryngopharynx swelling and pain.The Radix Rehmanniae clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Be used for calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.
The effect of Radix Rehmanniae: have the clearing away heat and cooling blood effect and be used for the warm febrile disease blood of joining the army, high fever coma, xerostomia crimson tongue.As qingying decoction.Control the convalescent stage of febrile disease, waste heat to the greatest extent, do not hinder by cloudy liquid, night fever abating at dawn, and red tongue rapid pulse person is as QINGHAOBIEJIATANG.Can be used for controlling the warm febrile disease blood of joining the army, the heat in blood poison is contained, hematemesis and epistaxis, and macule is purple black.As four holy balls.It is thirsty that the YIN nourishing and the production of body fluid promoting effect is used for Tianjin wound, and interior-heat is quenched one's thirst.Control the epidemic febrile disease impairment of YIN, the dryness of the intestine constipation is as Zengye Tang.Decoction when medicinal, 10～30g, the fresh goods consumption doubles, or smashes juice with fresh goods and be used as medicine.Bright Radix Rehmanniae sweet in the mouth bitterness Great Cold acts on similarly to Radix Rehmanniae, and the power of YIN nourishing is slightly inferior, but clearing away heat and promoting production of body fluid, the power of cooling blood for hemostasis is stronger.This product is cold in nature and stagnant, and damp-retention due to hypofunction of the spleen abdominal distention loose stool person should not use.
Modern study:
1. chemical composition: this product contains 20 various trace elements, the cupreols etc. such as catalpol, dihydro catalpol, single close Z-TEK glycosides, acetylcatalpol, aucubin, close Z-TEK glycosides, Martynoside., geniposide, ajugoside, sad, benzoic acid, phenylacetic acid, glucose, sucrose, fructose and ferrum, zinc, manganese, chromium.Radix Rehmanniae contains 20 several amino acids, and wherein arginine content is the highest.Contain 15 seed amino acids in Radix Rehmanniae, wherein alanine content is the highest.
2. pharmacological action: this product water extraction liquid has blood pressure lowering, calmness, antiinflammatory, anti-allergic effects; Its fluid extract has heart tonifying, diuresis; Its ethanol extraction has the effect of shortening clotting time; LIUWEI DIHUANG WAN take it as principal agent has blood pressure lowering, improves renal function, antitumor action; Radix Rehmanniae has antagonism to take continuously the decline of plasma corticosterone concentration after dexamethasone, and can prevent the effect of Adrenal cortex atrophy, has the effect that promotes the lymphoblastic conversion of body, increases the T lymphocyte quantity, and can strengthen the phagocytic function of reticuloendothelial cell, more obvious to immunologic hypofunction person effect especially.
3. clinical research: in conjunction with going out blood disorder with this product treatment heat in blood traditionally, modern clinic is in order to treat the diseases such as idiopathic thrombocytopenic purpura, dysfunctional uterine hemorrhage; Use Radix Rehmanniae 120g, Radix Scutellariae 60g, Radix Sophorae Flavescentis 30g is decocted in water for oral dose, treatment lupus erythematosus acroesthesia 20 examples, clinical whole healings (Shandong journal of Chinese medicine, 1981,2:93); Make concentrated mixture with medicines such as Radix Rehmanniae, Cortex Phellodendri, the Rhizoma Anemarrhenae, Radix Scrophulariaes for oral administration, treatment Treating Female Idiopathic Sexual Precocity 51 examples, have significant curative effect (Chinese combination of Chinese and Western medicine magazine, 2001,10:732); Reuse Radix Rehmanniae and join the Radix Astragali, Radix Pseudostellariae, Radix Ophiopogonis, Cortex Moutan, Poria, be decocted in water for oral dose, the treatment 30 cases of viral myocarditis, total effective rate 70% (journal of shanghai Chinese medicine, 2001,3:19); In addition, clinical also with Radix Rehmanniae treatment rheumatism and rheumatic arthritis, Sheehan syndrome, eczema, neurodermatitis, urticaria, constipation and other diseases.Radix Rehmanniae injection can be used for infectious hepatitis, diabetic neuropathy patient.
This shows the holy product of health care really of Radix Rehmanniae.Complete golden health preserving contains abundant Radix Rehmanniae in the source, and be rich in the effectively nutritional labeling such as Radix Polygoni Multiflori, Rhizoma Dioscoreae, Herba Epimedii, JUKE, microcrystalline Cellulose, tea polyphenols, multiple nutritional components is divided the work separately, combined effect again, completes the health care to health, brings into play its magical curative effect.
(3) Radix Panacis Quinquefolii:
Be a kind of of Radix Ginseng, claim again panacis quinquefolii radix, Radix Panacis Quinquefolii, because the U.S. is once called as the United States of America gain the name, originate in northern US to the southern band of Canada, take the Wisconsin State as main.Usually be divided into (general alleged) Radix Panacis Quinquefolii and Canada's ginseng according to the place of production; Although both are of the same race, because climatic effect, the former ginseng face band is more obvious than the latter, and active constituent content is also higher.Instructions of taking boils, stewes, steamed wheaten foods, the containing of also can cutting into slices or be ground into fine powder and take after mixing it with water.
This product is the dry root of Araliaceae Radix Panacis Quinquefolii Panax quinquefolium L..Be all the cultivation product, excavate autumn, cleans, and dries or cold drying.Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Be used for the deficiency of vital energy thanks to cloudy, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired tired, quenches one's thirst, dryness of the mouth and throat.Radix Panacis Quinquefolii has the effect of resisting fatigue, antioxidation, anti-stress, anticoagulant, reduction blood coagulation, in addition, diabetics is regulated in addition the effect of blood glucose.
The effect of Radix Panacis Quinquefolii:
1. enhancing central nervous system function: the Saponin in Radix Panacis Quinquefolii can effectively strengthen nervus centralis, reach with all worries set aside with fixed attention, the effects such as allaying tiredness, memory reinforcing, applicable to symptoms such as insomnia, irritated, hypomnesis and senile dementias.
2. protection cardiovascular system: the informal dress Radix Panacis Quinquefolii can arrhythmia, resist myocardial ischemia, anti-myocardium oxidation, strengthen cardiac contractility ability, but the patients with coronary heart disease Symptoms is deficiency of both QI and YIN, palpitation and short breath long-term taking Radix Panacis Quinquefolii, and is evident in efficacy.The effect of Radix Panacis Quinquefolii also is to regulate blood pressure, can effectively reduce temporary and the persistency blood pressure, helps the recovery of the diseases such as hypertension, arrhythmia, coronary heart disease, acute myocardial infarction, cerebral thrombosis.
3. raising immunity: Radix Panacis Quinquefolii is as the first-selected medical material of qi-tonifying health-care, can promote that serum albumin is synthetic, bone marrow protein is synthetic, organ albumen is synthetic etc., improves immunity of organisms, and cancer is effectively resisted in the anticancer growth.
4. promote the blood vigor: the long Radix Panacis Quinquefolii that takes can reduce blood coagulation, suppresses platelet aggregation, atherosclerosis and promote Growth of red blood cells, increases hematochrome.
5. treatment diabetes: Radix Panacis Quinquefolii can reduce blood glucose, regulates insulin secretion, promote carbohydrate metabolism and lipid metabolism, the treatment diabetes are had certain assosting effect.
Radix Panacis Quinquefolii has YIN nourishing and QI supplementing, the double effects that the mind calming and mentality promoting and clearing away heat and promoting production of body fluid, pathogenic fire reducing are relieved summer heat. the archaism cloud: " Radix Panacis Quinquefolii is cool in nature and mend, all wishs be not subjected to Radix Ginseng the warm person of Radix Ginseng all available it " therefore. mend and not dry be the special feature of Radix Panacis Quinquefolii.
1. strengthen the mobility of cardiac muscle and enhancing heart;
2. strong nervus centralis, stabilize body and mind and also set up, and calmness and antialcoholism action are arranged, and the hypermnesis ability has remarkable efficacy to the Alzheimer;
3. blood pressure there is Accommodation, makes temporary or the persistency blood pressure drops. suppress arteriosclerosis and promote Growth of red blood cells, increasing the deal of hematochrome;
4. can regulate the secretion of islets of langerhans, therefore powerful to diabetes;
5. liver there are the secretion of regulating the accessory suprarenal glands element, the effect that enhances metabolism;
6. can physical strength reinforcing and athlete's tool is greatly benefited;
7. anticancer growth increases immunologic function;
8. encourage digestion, to chronic gastropathy and the weak effect that helps of the intestines and stomach.
Its side effect is:
The Radix Panacis Quinquefolii overdose is also bad, can bring excited, irritated worried, the insomnia of mood to the people, similar corticosteroid central nervous excitation and the irritations such as personality forfeiture or mental disorder occur.According to expert introduction, although Radix Panacis Quinquefolii has good tonic effect, being not that everybody is suitable takes, and is not also to eat, and immunity will improve immediately.From taking generation effect in health, need a process.
Although applicable crowd is very wide for Radix Panacis Quinquefolii, if medicine is not suited the medicine to the illness, also can play retroaction.
The traditional Chinese medical science thinks, Radix Panacis Quinquefolii belongs to the medicine of a cold nature, should boosting qi and nourishing yin.If health has heat symptom-complex,, health frequent fatigue and weak rubescent such as xerostomia agitation, feverish sensation over the palm, face use Radix Panacis Quinquefolii class tonic can reach the purpose of taking good care of.Otherwise, if bring up phlegm when one coughs, saliva is many or when the state such as edema is arranged, just should avoid taking Radix Panacis Quinquefolii, otherwise will increase the weight of the state of an illness.In addition, " non-void is not mended ".If health there is no discomfort, should not often take Radix Panacis Quinquefolii buccal tablets.
In addition, Radix Panacis Quinquefolii is unfavorable for wet disease, also will consider seasonality when taking.Spring and summer climate was do, relatively be fit to take Radix Panacis Quinquefolii, should not take Radix Ginseng or Radix Ginseng Rubra; And autumn, winter the Radix Ginseng of taking preferably.
(4) Herba Epimedii:
Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Be used for impotence and seminal emission, the muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.Be used for that impotence due to deficiency of the kidney, seminal emission premature ejaculation, waist knee joint flaccidity are soft, cold extremities with aversion to cold.Control the sexual impotence spermatorrhea, can join the product such as Rhizoma Curculiginis, Fructus Corni, Herba Cistanches; Control waist knee joint flaccidity soft, can join the product such as the Cortex Eucommiae, Radix Morindae Officinalis, Rhizoma Cibotii.Also can be used for arthralgia due to cold-dampnes or spasm of the limbs numb.The dispelling the wind and dampness pathogens arthralgia pain is partial to cold-damp person, and numb limbs and tense tendons is meciless or muscles and bones contracture etc., can with the compatibilities such as Radix Clematidis, Radix Morindae Officinalis, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Chuanxiong.
The effect of Herba Epimedii:
1. treatment poliomyelitis: get Herba Epimedii, Herba Taxilli equivalent, make the injection of each 1 gram of every 2 milliliter containeds.Acute stage is take intramuscular injection as main, Acupuncture Combined with Point Injection Acupuncture.Each 2 milliliters of intramuscular injection, every day 2 times, continuous 20 days.Convalescent period and sequela stage coordinate intramuscular injection take acupoint injection therapy as main.Acupoint injection therapy is acupoint selection routinely, 1～2 milliliter of every cave injection, the next day 1 time, continuous 20 days, the rest first quarter moon is continual cure again.Treat each phase poliomyelitis totally 246 examples, patients during acute stage 34 examples wherein, recovery from illness 8 examples, 16 examples that are almost recovered, remarkable effective 7 examples, effective 2 examples, invalid 1 example; Reconvalescent's 43 examples, recovery from illness 21 examples, effective 15 examples, progressive 5 examples, invalid 2 examples; The sequela stage patient is totally 169 examples, fully recovers and 9 examples that are almost recovered, and significantly effectively reaches effective 129 examples, invalid 31 examples.According to observations, this product is to acute stage and just to have entered convalescent case evident in efficacy, recovers very fast.Sequela stage is also had certain effect, and medication future trouble limb generally has heating, energetically waits sensation, and effectively the visible muscle of case recovers gradually, suffers from limb and increases slightly; Wherein better with a crural paralysis person curative effect, upper limb paralysis and older person's curative effect are relatively poor.Except the xerostomia phenomenon is arranged, have no other side effect after medication.
2. treat the neurasthenia: the excessive sheep flower bud of use 3% a decocting liquid alien penetrates method, and every day 1 time, 10～20 times is a course for the treatment of.Small number of patients separately takes tranquilizer.Observe 104 examples, recovery from illness 22 examples, marked improvement 21 examples, progressive 46 examples, invalid 15 examples.The course for the treatment of, elder's curative effect was better; After treatment, symptom begins to take a turn for the better more early, and curative effect and is treated 15 state of an illness still without improvement person better, even continual cure, curative effect is also not remarkable, and does not consolidate.The minority case treatment initial stage can mild reaction occur or symptom temporarily increases the weight of, but continual cure namely rapidly disappears.Each 5 milliliters of dual-purpose 20% Herba Epimedii tincture, every day 3 taking medicine before meal, continuous 2～March.Treat 50 examples, approximately have 80% patient to control rear symptom and eliminate or alleviate.Period in a medicine has no untoward reaction, and process of excitation is preponderated or hypersexuality but be not suitable for, and the hyperpietic.
3. treatment chronic tracheitis: observe more than 1000 examples with single Herba Epimedii ball, the effective percentage of a course for the treatment of is 74.6%, and control and obvious effective rate are 22.1% in the recent period.As coordinating Herba Ardisiae Japonicae etc. to form compound treatment, curative effect increases.Facts have proved, the curative effect of simple type is better than the type of panting, and older person's curative effect is relatively poor, but course of disease length and curative effect are without obvious relation; Eliminate the phlegm, antitussive effect is better, relieving asthma relatively poor; Through control two the course for the treatment of person be significantly increased than recent control and the obvious effective rate of a course for the treatment of.In observation, once to following up a case by regular visits to through 110 examples of controlling a course for the treatment of, the effective percentage after half a year as a result is 59.1%, and more originally curative effect descends 26.1%.Preparation and usage: get Herba Epimedii stem, leaf (dry product), take extract with 80% of its total amount, 20% levigation, both are mixed into ball.Every feed ration is equivalent to 1 liang of crude drug, twice sub-service.Once to be equivalent to the dosage (daily dose) of crude drug 5 money and 1.5 liang, respectively some cases is observed in treatment, both are all substantially similar to taking 1 day for curative effect as a result.The rear section case of taking medicine has minor response, take xerostomia, nauseating as common, is secondly abdominal distention, dizziness, generally can die away.
Pharmacological action:
1. the effect of Endocrine: Herba Epimedii can promote that sexual function is because gonepoiesis is hyperfunction, and after seminal vesicle was full of, sensation was neural, indirect excitation libido and causing.Herba Epimedii main component Herba Epimedii can obviously promote mouse epididymis and the growth of seminal vesicle childhood, and Herba Epimedii has the effect of androgen sample.
2. on the impact of function of immune system: kidney deficiency human T-cell quantity, drench rate of rotation, antibody, antigen and reticuloendothelial system phagocytic hypofunction, and treatment can improve all through kidney-reinforcing drugs such as Herba Epimedii
3. to the effect of cardiovascular system: with Herba Epimedii decoct and extract, the myocardial ischemia in rats that pituitrin causes is had certain protective role.Hypotensive effect, Herba Epimedii decoct and decocting alcohol leaching liquid all are hypotensive effect to rabbit (2.5ml/kg), cat (2ml/kg) and the quiet notes of rat (4ml/kg).Wherein with the most obvious to the rabbit effect.
4. to the effect of blood system: Herba Epimedii decoct, polysaccharide and total flavones are to the effect of Platelet relatively, after the oral Herba Epimedii decoct of Healthy People, red blood cell hematocrit obviously reduces, and erythrocyte electrophoretic time shortens, erythrocyte sedimentation rate is accelerated, thereby whole blood contrast viscosity is obviously reduced.
5. on the impact of metabolism: Herba Epimedii has the effect that promotes that DNA is synthetic.
6. function of resisting osteoporosis: experiment showed, that Herba Epimedii has the anabolic effect that promotes medullary cell DNA, illustrates that Herba Epimedii has the osteoporotic effect of good control.
The Herba Epimedii stem and leaf contains icariine and volatile oil.Verified, Herba Epimedii has the effect of androgen sample, and its effect is better than Gecko and Hippocampus.Clinical demonstration, it is by promoting gonepoiesis, and is conversely again can sensation neural after making seminal vesicle be full of seminal fluid, thereby excites libido and cause erection.Simultaneously, Herba Epimedii can also suppress vasomotor center, and the expansion peripheral vessels makes blood pressure drops, and can antitussive, eliminate the phlegm, relieving asthma, poliovirus, Staphylococcus albus, staphylococcus aureus etc. are also had significant inhibitory action.
Herba Epimedii is mainly used in treating reproduction, osteoarthrosis, respiratory system disease clinically.Herba Epimedii compatibility Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, the Cortex Eucommiae, Rhizoma Curculiginis, Radix Morindae Officinalis, Fructus Corni, Fructus Cnidii, Semen Allii Tuberosi, Herba Cistanches, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi are called " praise and educate pellet ", can control sexual impotence, premature ejaculation.Herba Epimedii compatibility Radix Clematidis, Fructus Xanthii, Rhizoma Chuanxiong can be controlled arthralgia.How many Herba Epimedii is regardless of, and fries in shallow oil soup and gargles, and can control toothache.Get Herba Epimedii and add Herba Ardisiae Japonicae and fry in shallow oil soup and take, can control chronic bronchitis, its eliminating phlegm and relieving cough plays a role clearly.Get Herba Epimedii and the Radix Astragali, Radix Codonopsis, Radix Aconiti Lateralis Preparata, Herba Asari, Herba Ephedrae etc. and decoct same use, the attitude of can curing the disease sinus syndrome and atrioventricular block.
(5) Rhizoma Polygonati:
Rhizoma Polygonati is tonic Chinese medicine commonly used.Be Liliaceae Polygonatum Polygonatum Mill herbaceos perennial, medicinal its rhizome.Kind more than 40 is arranged in the world, and China has more than 30 to plant, and medicinal kind has more than 10 to plant." the Chinese pharmacopoeia regulation as Rhizoma Polygonati medicinal 3 kinds of crude drug in whole are arranged; Rhizoma Polygonati P.sibiricum Redoute, Polygonatum cyrtonema Hua P.cyrtonema Hua and Yunnan Rhizoma Polygonati P.kingianum Coll.et Hemsl.Rhizoma Polygonati is flat, sweet in the mouth; Return spleen, lung, kidney channel; Have the functions such as boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying; Quench one's thirst for weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat.
Rhizoma Polygonati has higher medical value, and the research of relevant Rhizoma Polygonati chemical composition is reported in rising trend recently.So far determined mainly to contain polysaccharide, steroidal saponin, flavone, anthraquinone analog compound, aminoacid isoreactivity composition in Rhizoma Polygonati.
1. saccharide: contain polygonatum polysaccharide first, second, the third 3 kinds in Rhizoma Polygonati, be comprised of glucose, mannose and galacturonic acid (6: 26: 1), its molecular weight is all greater than 200,000; Rhizoma Polygonati also contains 3 kinds of oligosaccharide, oligosaccharide first (molecular weight is 1630,8 fructose and 1 glucose), second (molecular weight is 862,4 fructose and 1 glucose), third (molecular weight is 174,2 fructose and 1 glucose).In Rhizoma Polygonati, total polysaccharides content is 11.74%.The Yunnan Rhizoma Polygonati also contains mannose.
2. steroidal saponin: all contain multiple steroidal saponin in Rhizoma Polygonati and Yunnan Rhizoma Polygonati.As furan gonane saponins (huangjinoside A, sibiricosides a), spirostane class soap formula (huangjinoside B, Bsibiricosdes B) etc.
3. flavone, anthraquinone analog compound: contain vitexin xylose formula (vi texin xyloside) and 5 in the Polygonatum cyrtonema Hua leaf, the glucosides of 4 '-dihydroxyflavone; Contain acridine-2-carboxylic acid (azetidine-2-carboxylic acid), digitalis essence glycosides (digitalis glycoside) and multiple anthraquinone analog compound in its rhizome.
4. aminoacid and trace element: Rhizoma Polygonati contains 8 kinds of trace element of 11 seed amino acids such as lysine and needed by human; Contain aspartic acid, homoserine (homoserine), DAB in Polygonatum cyrtonema Hua.
Rhizoma Polygonati is used as medicine with rhizome.Has boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, the interior-heat disease such as quench one's thirst.Very effective in cure for diabetes.
Chinese medicine is controlled weakness of the spleen and stomach, fatigue and asthenia, and inappetence, cardiopalmus is breathed hard, deficiency of the lung cough caused by dryness, Tianjin wound is thirsty, diabetes, deficiency of kidney essence, soreness of the waist and knees; Tinea pedis is controlled in external; Mongolian medicine training the body body is weak, cold syndrome of the stomach, and dyspepsia, food stagnation, diarrhea due to improper diet, renal cold, spermatorrhea, sexual impotence is had a dizzy spell, cold " Xi Riwu element " disease, lumbago and skelalgia, " Ba Dagan " disease.
The pharmacological action of Rhizoma Polygonati:
1. resisting pathogenic microbes effect: Rhizoma Polygonati has inhibitory action to acid-fast bacilli in vitro, to experimental Cavia porcellus lungy, with decoct lymph enlargement administration again after infecting tulase administration simultaneously and infecting respectively, significant fungistatic effect is all arranged, health status has clear improvement, and its curative effect and isoniazid approach.Bacillus typhi is only had faint inhibitory action, and (antibiotic least concentration is: 500-1000 milligram %).Rhizoma Polygonati alcohol extraction aqueous solution 2% above concentration has in various degree inhibitory action to multiple common pathomycete.Its 1: 10 concentration is to gland, and virus has the slow effect in the court of a feudal ruler, and herpesvirus is had inhibitory action.
2. on the impact of blood glucose: rabbit gavage Rhizoma Polygonati extractum, its blood sugar content increases gradually, then reduces.The blood glucose that Rhizoma Polygonati extractum causes epinephrine is too high is remarkable inhibitory action.
3. antifatigue effect: Rhizoma Polygonati decoct 17.67% a concentration 0.3ml/ lumbar injection can extend the mice swimming time.
4. antioxidation: Rhizoma Polygonati decocting liquid 20% concentration, 13ml/ only feeds drink, and continuous 27 days, make that mouse liver superoxide dismutase (SOD) is active to raise, myocardium lipofuscin content reduces.
5. delaying senility function: Rhizoma Polygonati decoct, 20% concentration soak Folium Mori and feed silkworm, and the effect that extends the silkworm larva phase is arranged.
6. anastalsis: Rhizoma Polygonati methanolic extract 40mg/ only, n-butyl alcohol part 20mg/ only, water layer part 20mg/ only, lumbar injection, to the freezing mouse tail of dry ice-methanol 1 minute, the experiment of back-end crop method showed that anastalsis is arranged, and the mice amount of bleeding is reduced.
7. to Cardiovascular: Rhizoma Polygonati aqueous extract 0.16-0.26g/kg intravenous injection obviously increases the anesthetized dog coronary flow; 1.5g/kg intravenous injection, the Cor Leporis myocardial ischemia that pituitrin is caused has antagonism, and the T ripple that the antagonism pituitrin causes increases, and promotes the T ripple to recover extremely in advance; The 12g/kg lumbar injection can strengthen mice to the tolerance of anoxia.
8. antivirus action: 0.2% drop eye of polygonatum polysaccharide, 6 times/days, or add polygonatum polysaccharide 10mg/kg, 2 times/days, the experimental herpes simplex keratitis of rabbit all there is therapeutical effect.
9. other effect: Rhizoma Polygonati decoct 6g/kg gavage, continuous 10 days, can improve Movse Erythrocyte Membrane Na+, the K+-ATP enzymatic activity.40% 0.3ml/ of Rhizoma Polygonati alcohol extract lumbar injection can improve mouse cardiac muscle, liver, spleen histiocyte DNA to the incorporation efficiency of 3H-TdR.0.5g/ gavage of Rhizoma Polygonati decoct makes mice plasma cAMP, and cGMP content all descends, and it is more to descend with cGMP, so cAMP/cGMP ratio organizes cAMP greater than matched group to spleen, and cGMP content all rises, but cAMP/cGMP ratio is without significant change.
Resisting fatigue and the antioxidation of research coarse solomon's seal polysaccharide.Method resisting fatigue experiment: investigate coarse solomon's seal polysaccharide to the impact of mice burden swimming time, serum urea nitrogen and hepatic glycogen content; Antioxidation experiment: investigate the impact of MDA content and GSH-Px activity after the mouse liver injury that coarse solomon's seal polysaccharide induces bromobenzene.Male SD mice is divided into coarse solomon's seal polysaccharide high dose group (0.72gkg-1), middle dosage group (0.36gkg-1), low dose group (0.18gkg-1) and blank group (distilled water) at random, the antioxidation experiment adds model group, every group 10, continuous gavage 14d.Mice serum urea nitrogen content and increase Mouse Liver glycogen content after but coarse solomon's seal polysaccharide significant prolongation mice burden swimming time, reduction are moved as a result, and be dose-dependence; Coarse solomon's seal polysaccharide can significantly reduce the lipid peroxidation product MDA content of bromobenzene induced mice hepatic injury, the superoxide dismutase GSH-Px content of increase murine liver tissue, and is dose-dependence.The conclusion coarse solomon's seal polysaccharide has obvious resisting fatigue and antioxidation.
(6) Poria:
The Poria slightly sweet flavor is flat, enters the heart, lung, spleen channel.Has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can control dysuria, the edema distension, the phlegm retention cough with dyspnea, vomiting, malignant histocytosis is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria reaches by strong activating the spleen pulmonary function, and is different from the Chinese medicine of other direct diuretic.Linggui zhugan decoction, decoction of four noble drugs, four Siberian cocklebur soup etc. are all effects that the prescription Poria commonly used of Poria compatibility is arranged:
1. diuresis: 1. with the Poria crude drug with 70% ethanol merceration, will soak to get the vaporized alcohol of liquid during use, the adding distil water dilution to finite concentration, then selects Healthy Rabbits to press the body weight drug administration by injection, the chronic experiment result shows, after medication, the urine amount is significantly increased.2. give dog intravenous injection Poria decoct (0.048g/kg), the urine amount does not increase as a result, and is also invalid or effect is very weak to rat; To urinate discharge capacity and chlorine excretion as observation index, to rat (fasting 12 hours) gavage, result is under this experiment condition with the Poria decoct, and Poria can not show the effect of its diuresis row chlorine.3. Poria does not have the effect of anti-desoxycortone.
2. antibacterial action: 100% decoct of Poria all has inhibitory action with the flat board method that burrows to staphylococcus aureus, escherichia coli, Bacillus proteus etc.Poria is without bacteriostasis to the bacteriostatic test result with test tube method.The ethanol extraction of Poria can kill leptospira external, but decocting liquid is invalid.
3. on the impact of digestive system: Poria has direct relexation to family's rabbits infestines, the formed ulcer of rat pylorus ligation is had preventive effect, and can fall gastric acid.Separately Liver Damage in Rats due to CCl4 there is significant protective effect, gpt activity is obviously reduced, prevent hepatic necrosis.
4. antitumor action: 1. the main component in Poria is pachyman (Pachyman), and content is very high.Pachyman itself if cut off its contained β-(1 → 6) Glucopyranose. side chain, becomes simple β-(1) without anti-tumor activity; 2. different way of administration: the various route of administration of pachyman system, tumor killing effect also is not quite similar.With the inhibition test of carboxymethyl pachyman to sarcoma 180, be used in conjunction 10 days for Switzerland's mice 5mg/kg dosage, the lumbar injection tumour inhibiting rate is 99.1%; The intramuscular injection tumour inhibiting rate is 96.5%; The intravenous injection tumour inhibiting rate is 99.6%; The subcutaneous injection tumour inhibiting rate is 86.3%; Oral tumour inhibiting rate is 8.8%; 3. the mice of different lines: the fungus polysaccharide body is done experiment with mice or the hybrid Mus of different lines, and its tumor killing effect difference is very large.Do experiment with the mice of ICR/TCL, ddys, SWM/MS, C57BL/6 strain as fragrant wild rice polysaccharide (Lentinan), strong tumor-inhibiting action occurs, its tumor suppression is 85-99%; Mice with the C3H/He strain is cooked experiment, its tumour inhibiting rate is 37-48%, and do experiment with the mice of BALB/C and DBA/2 strain, method is undertaken by the unified antineoplastic agent object interior screening rules (draft) in the whole nation in 1978, result tumour inhibiting rate greater than 30% once occurred to sarcoma 180,29.6%, 18.9% tumour inhibiting rate also occurred and without the tumor suppression phenomenon; Inhibitory action to mouse tumor U 1 is also not obvious.And with same novel carboxymethyl pachyman injection, test with 500mg/kg, 100mg/kg, 50mg/kg, 25mg/kg dosage, ICR/JCL mouse tumor U 1 all has tumor-inhibiting action as a result, and its tumour inhibiting rate is 75.5-92.7%.
5. the impact of pachyman body on immunologic function:
1. increase the cytotoxic effect of macrophage: pachyman, hydroxyethyl pachyman-3, hydroxyethyl pachyman-4, lumbar injection can obviously strengthen the cytotoxic effect of mouse peritoneum emigrated cell (PEC); Pachyman, hydroxyethyl pachyman-1, hydroxyethyl pachyman-2 also have certain effect.Test with novel carboxymethyl pachyman, result shows can strengthen the PEC cytotoxic effect, and cytophagous phagocytic rate and phagocytic index are obviously increased.Subcutaneous continuous injection 5 days, 50mg/kg dosage make Peritoneal macrophage function increase by 35.5%, and phagocytic index increases by 58.0%; Subcutaneous continuous injection 10 days, 50mg/kg dosage make phagocytic rate increase by 66.1%, and phagocytic index increases by 121%.Novel methyl pachyman can also antagonism immunosuppressant cortisone acetate to the inhibition of macrophage function.Give the novel carboxymethyl pachyman of mice continuous subcutaneous injection 10 days (50mg/kg. days), cortisone matched group and carboxymethyl pachyman added the equal subcutaneous injection cortisone acetate of cortisone test group (100mg/kg/ days) 3 days from the 8th day, and the phagocytic rate of cortisone matched group and phagocytic index are 18.86 ± 3.40% and 0.41 ± 0.09; The phagocytic rate of test group and phagocytic index 34.81 ± 1.75% and 0.86 ± 0.07.Novel methylol pachyman can make that the macrophage phagocytic function of Lewis lung cancer C57 mouse inbred lines and lotus sarcoma 180 Switzerland mice is low recovers normal.C57 mouse inbred lines subcutaneous vaccination Lewis lung cancer cell is after 24 minutes, the novel carboxymethyl pachyman of continuous subcutaneous injection (50mg/kg/ days) 10 days, phagocytic rate and phagocytic index are respectively as a result: (1) normal mouse group: 39.60 ± 4.86% and 0.99 ± 0.20; (2) band Lewis lung cancer group: 24.44 ± 3.38% and 0.55 ± 0.10; The band Lewis lung cancer adds novel carboxymethyl pachyman group: 59.26 ± 6.50% and 1.30 ± 0.21.Switzerland's mouse hypodermic inoculation sarcoma 180 cell is after 24 hours, the novel carboxymethyl pachyman of subcutaneous continuous injection (50mg/kg/ days) 10 days, and phagocytic rate and phagocytic index are respectively as a result: (1) lotus tumor group: 26.88 ± 4.57% and 0.74 ± 0.11; (2) the lotus tumor adds novel carboxymethyl pachyman group: 45.92 ± 4.13% and 1.57 ± 0.12.Separately have pharmacological evaluation to show, novel carboxymethyl pachyman can obviously improve phagocytic rate and the phagocytic index of Turnover of Mouse Peritoneal Macrophages.Injected novel carboxymethyl pachyman (300mg/kg/ days) 7 days to mouse peritoneal, the phagocytic rate of peritoneal macrophage is 38 ± 2.46%, and phagocytic index is 0.67 ± 0.04; The phagocytic rate of matched group is 19.4 ± 1.27%, and phagocytic index is 0.32 ± 0.02.
2. the methylol pachyman can obviously strengthen mice spleen antibody secreting cell number (PFC) and special antigen binding cell number (SRFC).The methylol pachyman increases with the increase with dosage the potentiation of PFC and SPFC; Can obviously strengthen the delayed hypersensitivity that mice is induced BSA.After 4 days, the DTH significant reaction that mice BSA induces strengthens to be compared with matched group through lumbar injection for methylol pachyman 100mg/kg/ days, and P＜0.01 difference is showing; The methylol pachyman can obviously strengthen the growth of mice spleen SCIF (TCGF).After 4 days, the TCGF amount that mouse boosting cell is stimulated by ConA and generates is obviously high than matched group through the abdominal cavity continuous use for methylol pachyman 100mg/kg. days, and the growing amount compared with normal mice of medication group mice TCGF increases by 3.5 times.
3. increase nonspecific acid esterase (ANAE) positive lymphocyte number.Take administration by gavage with pachyman be made into 250mg/kg/ days, 500mg/kg/ days, 1000mg/kg/ days three kinds of concentration test, continuous use 7 days, the 8th day non-specific esterase of detection of acidic (ANAD) positive lymphocyte number, hemolysis plaque (PFC), macrophage phagocytic etc., carried out simultaneously thymus, the mensuration of spleen and tumor weight, result proof pachyman can strengthen M phagocytic function (P＜0.01), increases ANAE positive lymphocyte number (P＜0.05).Can also make the mouse spleen antibody secreting cell count showed increased (P＜0.01), and have the function of anti-atrophy of thymus gland and anti-splenomegaly and inhibition tumor growth.
4. strengthen the lymphocytic cytotoxicity of T: the pachyman physical ability strengthens the lymphocytic cytotoxic effect of T, namely strengthens cell immune response, and therefore activates body to the immunological surveillance system of tumor, and this and its anti-tumor activity is closely related.I. test in the pipe: with 51Cr labels targets cell, the lymphocyte of cultivating 5 days is mixed with 1: 1 with the labels targets cell, with the index of 51Cr Release Number as the target cell damage.Observe accordingly lymphocytic cytotoxic effect.The polysaccharide body that adds various dose during test is observed the impact on lymphocytic cytotoxic effect.Result shows, pachyman and hydroxyethyl pachyman can make lymphocytic cytotoxicity strengthen 20-28 doubly in pipe, and pachyman and carboxymethyl pachyman can strengthen 4-7 times.Ii. in vivo test: do experiment with CBA mouse, begin to use the P815 oncocyte as the lymphocyte activator agent, make it sensitization, and in the various pachyman bodies of different number of days lumbar injection.Mice was put to death, take out splenocyte and mesentery lymphocyte (MLNC) in the 10th day.As the lymphocytic Cytotoxic target cell of T, mix (1: 100) with the splenocyte that has prepared and MLNC with certain proportion with the P815 oncocyte of 51Cr labelling, cultivated 3 hours, observe the 51Cr release rate.The various pachyman bodies of result proof all can strengthen the lymphocytic cytotoxic effect of T in vivo.In addition, the methylol pachyman of 100 μ g/ml has facilitation to the NK cytoactive.
6. on the impact of blood system: 1. can make caused by cyclophosphamide rat leukopenia accelerate.2. the Water Extract of Poria of containing water-soluble micromolecular polysaccharide can make Normal Erythrocytes 2, the 3 one DPG levels that exsomatize rise approximately 25%, and can effectively delay the exhaustion of 2,3 one DPG in the incubation process; Intravenously administrable mice integral body 2,3 one DPG levels are showing and are rising.3. the administration of Poria water decoction subcutaneous injection and gastric infusion all can make the mice plasma corticosterone obviously raise.
7. on central nervous system's impact: the Poria decoct is pressed the 5-10g/kg lumbar injection, to give in advance with caffeine or to the mice of caffeine, sedation is all arranged.The synergism of Poria and pentobarbital sodium.Poria decoct (10g/kg) fails obviously to extend the anesthesia duration of pentobarbital sodium; Make anesthesia duration than matched group significant prolongation more with the dosage of 40g/kg, along with the increasing of dosage, calm index also increases thereupon.This synergism may be due to due to their central inhibitory action, may be also to have hindered the decomposition of pentobarbital and excretion and cause anesthesia duration and extend.
(7) siritch:
1 〉. contain the unsaturated fatty acid useful to human body in siritch, and the ratio that forms is suitable, is not easy oxidation;
2 〉. especially be rich in and can enhance metabolism, improve the blood capillary circulation, bring the γ type vitamin e of skin cell nutrition, γ type vitamin is that excellent polyphenoils mass-energy prevents cell senescence effectively;
3 〉. the oleic acid composition that contains in siritch is also confirmed that the diseases such as the gastric ulcer of inhibition, asthma are arranged, prevents that skin quality from worsening, and improves the effect of immunity by medical science;
Alpha-linolenic acid in siritch again can blood fat reducing, anticoagulant, vessel softening, tonification brain, cancer, coronary heart disease, diabetes, carcinoma of prostate etc. there is the effect of prevention and treatment, so as long as we are long-term edible siritch, take precautions against fully resource just can for health, could promote the immunologic function of health, so siritch is the best health care condiment in edible oil.
Siritch sweet in the mouth, property are flat, nontoxic, and the effect of moistening dryness for relaxing bowels, nourishing blood to expel wind is arranged.Can cure the disease rear weakness, dizzy, constipation, old man's xerosis cutis, Scaling, allergic dermatitis, pruritus, skin infection eczema and hypertension, sclerosis of blood vessels, cholesterol such as increases at the disease.
The shortage of finding alpha-linolenic acid is the thing of the seventies in last century, the founder Xi Mo Prose doctor at American Genetic nutrient health center, from the omega-fatty acid that begins one's study in 1984 problem of having the balanced diet, China just began one's study in the nineties, provided the more diet style of science from nutrition and healthy angle for the mankind.The formation of omega-fatty acid theory comes from the large essential fatty acid of human body two: alpha-linolenic acid (omega-fatty acid) and linoleic acid (ω-6 fatty acid).Research finds, in the fat that human body is taken in, if the ratio of these two groups of essential fatty acid less than 1: 4, the function of human body will the most efficient, the risk that the various diseases such as cardiovascular, cancer, diabetes, obesity, arthritis, asthma are brought out in reduction.
In recent years, along with the progress of science and technology, the nutritive value of linum and health care have caused many field scientists' such as medical treatment, food, agricultural concern.A large amount of results of study show, siritch is a kind of high-quality edible oil, is rich in α one linolenic acid and various unsaturated fatty acid, can directly change into DHA and EPA in human body.Contain 55% linolenic acid in siritch, this is the highest in vegetable oil, is a kind of economical and practical " bathypelagic fish oil ".As everyone knows, " fish oil " refers to EPA and DHA, is to be become in the body of fish by alpha-linolenic acid (mainly being contained in Sargassum) in the sea.The people takes alpha-linolenic acid (mainly being contained in siritch), also can synthesize EPA and DHA in vivo.So eat the siritch that is rich in alpha-linolenic acid, just can play the effect of similar eating " fish oil "; The unsaturated fatty acid chain of restoration updating cranial nerve cell film plays brain-strengthening, nootropics, blood fat reducing, antiplatelet aggregation, expansion small artery and antithrombotic etc.
Above-mentioned formula after the science screening is compared with other formula, and is strong through taking effect property of animals and human beings body clinical experiment, successful.
Through zoopery, after this formula test, physical fatigue and aging are significantly improved, so this formula has mitigation to exercise fatigue and aging.In addition with this capsule to the Mus gavage, make mice plasma cAMP, cGMP content all descends, and it is more to descend with cGMP, so cAMP/cGMP ratio organizes cAMP greater than matched group to spleen, cGMP content all rises, but cAMP/cGMP ratio is without significant change; And medicine feed experiment in 30 days finds no the overt toxicity effect, according to the criterion in health food check and assessment technique standard (version in 2003) toxicological evaluation program, the food test agent helps the soft capsule of relieving sports fatigue and slow down aging without overt toxicity.
Through human experimentation, experiment conclusion: the experimenter of 30 routine physical fatigues requires to take the soft capsule 30 days that helps relieving sports fatigue and slow down aging, exercise fatigue be improved significantly, reach enhancing immunity, fatigue alleviating, astringing QI is calmed the nerves again, and flourish muscle is supported marrow, stomach function regulating activating the spleen, also improve simultaneously the blood oxygen circulation, illustrate that the soft capsule that helps relieving sports fatigue and slow down aging has the effect of fatigue alleviating.After helping the soft capsule test-meal use of relieving sports fatigue and slow down aging, routine blood test, routine urinalysis and blood biochemistry index illustrate that all in normal range this product has no adverse effects for the experimenter is healthy.
Soft capsule dose every day that helps relieving sports fatigue and slow down aging is every day three times, each two.Main edible crowd is exercise fatigue person and old and feeble patient.
The present invention compares the outstanding feature of following aspect with the formula that helps relieving sports fatigue and slow down aging: the present invention adopts the compound recipe form, meticulously select materials, rigorous prescription, pursue integral body and improve the human body situation, from fatigue alleviating and slow down aging, hypnosis, the aspect across-the-board regulation healths such as enhancing immunity, balanced nutrients.The human qi and blood running is unobstructed, Metabolism of Normal, and Sufficient Sleeping just is difficult for old and feeble.Cervus elaphus linnaeus, Herba Epimedii kidney invigorating and YANG supporting, strengthening the tendons and bones; The Radix Panacis Quinquefolii boosting qi and nourishing yin, relieve inflammation or internal heat and promote the production of body fluid; Rhizoma Polygonati lung moistening YIN nourishing, invigorating the spleen and replenishing QI; Poria promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing; Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Siritch has the effect of prevention and treatment to cancer, coronary heart disease, diabetes, carcinoma of prostate etc.Prescription improves health on the whole, fatigue alleviating and slow down aging.
2, technique of the present invention is advanced, the high-grade fashion of dosage form.
The related raw material of this formula is allotment after extracting, and has dwindled volume, is convenient to produce, and is comparatively advanced.Select siritch to make solvent, strengthened the effect of this formula.Siritch contains very high unsaturated fatty acid, and linolenic acid content at 55%-60%, is natural health care, and cardiovascular system is had protective effect, also has health-care effect very widely, comprises fatigue alleviating.Can reconcile blood glucose, blood fat, blood pressure, supplementing the brain, vision protection etc.
Adopt soft capsule dosage form, can protect to greatest extent active ingredient, can be convenient to again take and digest and assimilate, the high-grade fashion of dosage form.
Existing formula most of the adopt single components such as Radix Rehmanniae, Radix Panacis Quinquefolii, linolenic acid that help relieving sports fatigue and slow down aging relevant to the invention of this class, and the problem that this type of formula exists is that potentiation is relatively poor, and the present invention is more comprehensive, formula has increased Herba Epimedii, Rhizoma Polygonati, cervus elaphus linnaeus, with strong complementarity, potentiation is strong.
The specific embodiment:
Most preferred embodiment shown below is described in further detail:
Feed intake and produce 1000 of 0.6g/ grain soft capsules, formed by following weight portion:
Embodiment 1, a kind of soft capsule that helps relieving sports fatigue and slow down aging comprises: siritch 460 weight portions, cervus elaphus linnaeus lyophilized powder 10 weight portions, Radix Panacis Quinquefolii powder mince thing 20 weight portions, Radix Rehmanniae extract 30 weight portions, Rhizoma Polygonati extract 30 weight portions, Poria extract 20 weight portions, Herba Epimedii extract 30 weight portions
Embodiment 2, a kind of soft capsule that helps relieving sports fatigue and slow down aging comprises: siritch 495 weight portions, cervus elaphus linnaeus lyophilized powder 15 weight portions, Radix Panacis Quinquefolii powder mince 10 weight portions, Radix Rehmanniae extract 20 weight portions, Rhizoma Polygonati extract 10 weight portions, Poria extract 20 weight portions, Herba Epimedii extract 20 weight portions
Embodiment 3, a kind of soft capsule that helps relieving sports fatigue and slow down aging comprises: siritch 505 weight portions, cervus elaphus linnaeus lyophilized powder 20 weight portions, Radix Panacis Quinquefolii powder mince 20 weight portions, Radix Rehmanniae extract 10 weight portions, Rhizoma Polygonati extract 20 weight portions, Poria extract 10 weight portions, Herba Epimedii extract 15 weight portions
Embodiment 4, a kind of soft capsule that helps relieving sports fatigue and slow down aging comprises: siritch 420 weight portions, cervus elaphus linnaeus lyophilized powder 30 weight portions, Radix Panacis Quinquefolii powder mince 30 weight portions, Radix Rehmanniae extract 30 weight portions, Rhizoma Polygonati extract 30 weight portions, Poria extract 30 weight portions, Herba Epimedii extract 30 weight portions
Embodiment 5, a kind of soft capsule that helps relieving sports fatigue and slow down aging comprises: siritch 475 weight portions, cervus elaphus linnaeus lyophilized powder 10 weight portions, Radix Panacis Quinquefolii powder mince 20 weight portions, Radix Rehmanniae extract 20 weight portions, Rhizoma Polygonati extract 30 weight portions, Poria extract 15 weight portions, Herba Epimedii extract 30 weight portions
Embodiment 6, a kind of soft capsule that helps relieving sports fatigue and slow down aging comprises: siritch 525 weight portions, cervus elaphus linnaeus lyophilized powder 10 weight portions, Radix Panacis Quinquefolii powder mince 10 weight portions, Radix Rehmanniae extract 10 weight portions, Rhizoma Polygonati extract 20 weight portions, Poria extract 10 weight portions, Herba Epimedii extract 15 weight portions
Embodiment 7, a kind of preparation method that helps the soft capsule of relieving sports fatigue and slow down aging.Comprise the steps:
(1) raw material preparation
Rhizoma Polygonati, Radix Rehmanniae, Poria, Herba Epimedii are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, lixiviate 2-8 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.
Radix Panacis Quinquefolii is pulverized, and granularity is 0.1-0.5mm;
The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch;
Cervus elaphus linnaeus: (20)-(25) ℃ freezing cervus elaphus linnaeus, section, lyophilization, dried cervus elaphus linnaeus is pulverized, the granularity of sieving is 0.1-0.5mm, is the cervus elaphus linnaeus powder;
(2) with siritch, the raw materials such as cervus elaphus linnaeus, Radix Panacis Quinquefolii, Rhizoma Polygonati, Radix Rehmanniae, Poria, Herba Epimedii mix in proportion;
(3) press 0.6g/ grain dress soft capsule after mix homogeneously;
(4) sterilization bottling, mounted box;
(5) vanning warehouse-in, sale after the assay was approved.
Claims (4)
1. soft capsule that helps relieving sports fatigue and slow down aging is characterized in that including the raw material of following weight portion: siritch 360-540 weight portion, cervus elaphus linnaeus lyophilized powder 10-30 weight portion, the Radix Panacis Quinquefolii powder 10-30 weight portion that minces.
2. the soft capsule that helps relieving sports fatigue and slow down aging as claimed in claim 1 characterized by further comprising the raw material of following weight portion: Rhizoma Polygonati extract 10-30 weight portion, Radix Rehmanniae extract 10-30 weight portion, Herba Epimedii extract 10-30 weight portion.
3. as claim 1 and the 2 described soft capsules that help relieving sports fatigue and slow down aging, characterized by further comprising the raw material of following weight portion: Poria extract 10-30 weight portion.
4. the preparation method that helps the soft capsule of relieving sports fatigue and slow down aging as described in claims 1 to 3, is characterized in that, also comprises the steps:
(1) raw material preparation
Rhizoma Polygonati, Radix Rehmanniae, Poria, Herba Epimedii are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, lixiviate 2-8 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.
Radix Panacis Quinquefolii is pulverized, and granularity is 0.1-0.5mm.
The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch.
Cervus elaphus linnaeus: (20)-(25) ℃ freezing cervus elaphus linnaeus, section, lyophilization, dried cervus elaphus linnaeus is pulverized, the granularity of sieving is 0.1-0.5mm, is the cervus elaphus linnaeus powder.
(2) with siritch, the raw materials such as cervus elaphus linnaeus, Radix Panacis Quinquefolii, Rhizoma Polygonati, Radix Rehmanniae, Poria, Herba Epimedii mix in proportion.
(3) press 0.6g/ grain dress soft capsule after mix homogeneously.
Priority Applications (1)
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735610A (en) * | 2014-02-13 | 2014-04-23 | 北京世纪中康医药科技有限公司 | Granule for relieving body fatigue |
| CN103734695A (en) * | 2013-11-21 | 2014-04-23 | 荣成百合生物技术有限公司 | Anti-fatigue health capsule and preparation method thereof |
| CN104857046A (en) * | 2014-02-20 | 2015-08-26 | 吉林大清鹿苑保健科技有限公司 | Panax quinquefolius-hairy antler particles and preparation method thereof |
| CN105381184A (en) * | 2015-12-21 | 2016-03-09 | 钱得方 | Traditional Chinese medicine pills capable of improving immunity of human body |
| CN106036879A (en) * | 2016-07-04 | 2016-10-26 | 康美（北京）药物研究院有限公司 | Healthcare food capable of relieving physical fatigue and making method thereof |
| AU2015276657B2 (en) * | 2014-06-20 | 2017-12-14 | Sichuan Jishengtang Pharmaceutical Co., Ltd. | Pharmaceutical composition for preventing and treating senile dementia and preparation method thereof |
| CN107929413A (en) * | 2017-12-22 | 2018-04-20 | 复旦大学附属金山医院 | A kind of antifatigue Chinese medicine composition and its application and preparation method |
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| CN101485813A (en) * | 2009-02-21 | 2009-07-22 | 甘肃创兴生物工程有限责任公司 | Soft capsule for beauty treatment and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734695A (en) * | 2013-11-21 | 2014-04-23 | 荣成百合生物技术有限公司 | Anti-fatigue health capsule and preparation method thereof |
| CN103735610A (en) * | 2014-02-13 | 2014-04-23 | 北京世纪中康医药科技有限公司 | Granule for relieving body fatigue |
| CN104857046A (en) * | 2014-02-20 | 2015-08-26 | 吉林大清鹿苑保健科技有限公司 | Panax quinquefolius-hairy antler particles and preparation method thereof |
| AU2015276657B2 (en) * | 2014-06-20 | 2017-12-14 | Sichuan Jishengtang Pharmaceutical Co., Ltd. | Pharmaceutical composition for preventing and treating senile dementia and preparation method thereof |
| US10646536B2 (en) | 2014-06-20 | 2020-05-12 | Sichuan Jishengtang Pharmaceutical Co., Ltd. | Pharmaceutical composition for preventing and treating senile dementia and preparation method thereof |
| US11278584B2 (en) | 2014-06-20 | 2022-03-22 | Sichuan Jishengtang Pharmaceutical Cc | Pharmaceutical composition for preventing and treating senile dementia and preparation method thereof |
| CN105381184A (en) * | 2015-12-21 | 2016-03-09 | 钱得方 | Traditional Chinese medicine pills capable of improving immunity of human body |
| CN106036879A (en) * | 2016-07-04 | 2016-10-26 | 康美（北京）药物研究院有限公司 | Healthcare food capable of relieving physical fatigue and making method thereof |
| CN107929413A (en) * | 2017-12-22 | 2018-04-20 | 复旦大学附属金山医院 | A kind of antifatigue Chinese medicine composition and its application and preparation method |
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Application publication date: 20130515 |