A kind of Semen Cuscutae oral liquid improving immunity and preparation method thereof
Technical field
The present invention relates to, containing the health product deriving from plant composition, improve immunity particularly to one
Semen Cuscutae oral liquid of power and preparation method thereof.
Background technology
Immunity plays an important role in human life mechanism, and the nutrition of human body, fatigue, mood,
Environment, disease, medication, radiation etc. cause the immunity degradation of self.Over millions of years, the mankind are giving birth to
An environment being not only suitable for existence but also being fraught with risks alive, the mankind are able to survival, also obtain outstanding immunity
Power.Immunity is the product of biological evolution process thus.
The health of hypoimmunity is prone to infected or cancer stricken.A variety of causes makes the immune system can not be normal
Play protective effect, in the case, easily cause antibacterial, virus, fungus etc. and infect, therefore immunity
The low the most directly performance of power is exactly liable to illness.Because of the most ill, increase the weight of the consumption of body, so
Typically have a delicate constitution, the reduction of malnutrition, lethargy, fatigue and weak, appetite, sleep disorder etc.
Performance, sick, having an injection to take medicine has become homely food.The most sick will being lot more time to is recovered,
And usually recurrent exerbation.Health and intelligent development if things go on like this can be caused bad, the most easily induce great disease
Sick.Underlying causes be hypoimmunity or immunity unsound.When immune function of human body is lacked of proper care, or exempt from
When epidemic disease system is unsound, following point will recurrent exerbation: flu recurrent exerbation, tonsillitis are sent out repeatedly
Work, asthma recurrent exerbation, bronchitis recurrent exerbation, pneumonia recurrent exerbation, diarrhoea recurrent exerbation ...
So necessarily can't neglect.
The immune system that the usual body immunity said refers to human body is resisted exotic disease pathogenic microorganism etc. and is invaded
The ability of evil.In the case of body immunity is normal, human body self can resist considerable pathogenic bacteria
Infringement, it is to avoid human body is caused damage.Human immunity is the defence of human body pathogenic microorganism etc. to external world
Function, or perhaps system of defense, under normal circumstances, it ensure that human body is not micro-by extraneous cause of disease
Biological infringement.
Immunity refers to that body resists external invasion and attack, safeguards the ability of homoiostasis.Air fills
Expire various microorganism: antibacterial, virus, mycoplasma, chlamydia, fungus etc..At human body
In the case of hypoimmunity, they can become the pathogen of sense mornig shift.Although human body is to different
Pathogen can produce corresponding antibody, and to resist subinfection again, but antibody has specificity and time-bounded,
Such as streptococcus antibody can only protect body again not invaded by streptococcic, the most not in short period of time
The infection of other viruses can be resisted.The people of hypoimmunity cannot resist the invasion and attack of cold virus at all, this
It is only the true cause that Susceptible population frequently catches a cold.
Due to economic prosperity day by day, the continuous lifting of modern's living standard, cause the heat that people are too much
It is a lover of pleasure, does not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.
Society with fast rhythm lives, and the physical and mental health of modern is caused seriously by the operating pressure of keen competition
Threat, make people more than half be in sub-health state, show themselves in that dizziness, nervous, weak, food
Being intended to depressed, hypomnesis, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, it may be assumed that
Essence grain replaces coarse grain completely, substantial amounts of three-hypers (high heat, high protein, higher fatty acid), more than three (preservative
Many, flavour enhancer is many, hormone many) pesticide of residual, chemical fertilizer depositing in vivo in the absorption of food and food
Long-pending, it is less than normal to add air, pollution of waterhead and quantity of motion, goes down to make three-hypers disease (high blood for a long time
Pressure, hyperglycemia, hyperlipidemia), cardiovascular and cerebrovascular disease, cancer etc. so-called " modern civilization diseases " go up rapidly
Rise, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.
Semen Cuscutae is listed in top grade in Shennong's Herbal.Its abnormal smells from the patient is pungent, sweet, flat nontoxic.Merit
Can with cure mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, and legs and feet are soft
Weak unable, impotence and seminal emission, crazy talk, frequent micturition, urine have She to drip, dizziness and blurred vision, blurring of vision, ear
The diseases such as ring deafness and women's leukorrhagia, habitual abortion.Generally it is listed in top grade can taking for a long time,
Take improving eyesight for a long time to make light of one's life by commiting suicide and prolong life.But yang deficiency hyperactivity of fire, postcoital protrusion not flaccidity and constipation due to dry stool person prohibit clothes, according to individual human body
Matter, if there is sign of getting angry, just cuts out.It can cause sexual function hyperfunction.
" herbal classic is met former ": " Liver and kidney edema caused by disorder of QI is also for Semen Cuscutae, dispelling pathogenic wind for improving eyesight.Its property and flavor of peppery and warm matter is glued,
Warm up waist knee joint with the strong muscle of the Cortex Eucommiae to be as good as.Its merit specially in benefit marrow, hard muscles and bones, only spermatorrhea, stem essence of trembling with fear goes out,
Drown have She to drip, go knee joint soreness of the shank soft, old man's Liver and kidney deficiency of vital energy, lumbago knee joint is cold, close Fructus Psoraleae, the Cortex Eucommiae with it,
All fascias come under liver also.Deficiency of vital energy gb 1, without god person, helps it with Radix Ophiopogonis, and honeyed pill takes, effect.All postcoital protrusion
Not flaccidity, constipation due to dry stool, little water red puckery person not use, the most supporing yang also with its property.″
Modern selects some health foods or functional food to be provided to building body.The function of health product
Mainly improve blood circulation of human body, improve body immunity.The various health product sold on the market now,
Dragons and fishes jumbled together for medicine, and the amusement of great majority simply false propaganda, have does not only have health-care components, also make
Become the huge injury of the person.Chinese medicine odor is poor, and a lot of people are reluctant long-term taking;Even if taking, it is
Three points of poison of medicine, allow people's long-term taking time also produce resisting psychology.How the efficacy exertion of Semen Cuscutae to
Greatly the most do not injure human body, and be obviously improved mouthfeel, enable a person to accept, be that we are in the urgent need to address
Problem.Containing a large amount of safely and effectively active substance health product inside Semen Cuscutae, human body can be greatly improved
Immunity, always people expect the key of solution problem.
Summary of the invention
The technical problem to be solved is, the various health product sold the most on the market, medicine
Dragons and fishes jumbled together for product, and the amusement of great majority simply false propaganda, have does not only have health-care components, also result in
The huge injury of the person.Chinese medicine odor is poor, and a lot of people are reluctant long-term taking;Even if taking, it it is medicine
Three points of poison, allow people's long-term taking time also produce resisting psychology.Semen Cuscutae acrid-sweet flavor, property is put down, is entered liver, kidney
Two warps.There is the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive effect.Can be used for soreness of waist and knee joint, sexual impotence, early
Let out, pass out semen, the enuresis, frequent micturition She drip, tinnitus, dizziness dim eyesight, visual deterioration, threatened abortion, leukorrhagia
Deng disease.Add some blood circulation promoting and blood stasis dispelling, the light Chinese medicine of mouthfeel, do not affect mouthfeel, make people be prone to accept,
Can preferably reach to improve effect of immunity.
For solving above-mentioned technical barrier, the present invention provides a kind of Semen Cuscutae oral liquid improving immunity, its
In described Semen Cuscutae health tea, the parts by weight of various raw materials are: Semen Cuscutae 10~50 parts, Semen Coicis 10~20
Part, Radix Angelicae Sinensis 10~20 parts, Rhizoma Polygonati 10~20 parts, Fructus Corni 10~20 parts, Poria 10~20 parts, Radix Salviae Miltiorrhizae
10~20 parts, Radix Codonopsis 10~20 parts, Fructus Lycii 10~20 parts, Radix Polygoni Multiflori Preparata 10~20 parts, Radix Rehmanniae Preparata 10~20 parts,
The Rhizoma Atractylodis Macrocephalae 10~20 parts, Fructus Schisandrae Chinensis 10~20 parts, Fructus Ligustri Lucidi 10~20 parts, Radix Polygalae 10~20 parts, Radix Ophiopogonis 10~
20 parts, Radix Trichosanthis 10~20 parts, Radix Paeoniae Rubra 10~20 parts, Rhizoma Curculiginis 10~20 parts.
The Semen Cuscutae oral liquid of described raising immunity, the weight of various raw materials in its described Semen Cuscutae health tea
Amount number can be: Semen Cuscutae 10~30 parts, Semen Coicis 10~15 parts, Radix Angelicae Sinensis 10~15 parts, Rhizoma Polygonati 10~
15 parts, Fructus Corni 10~15 parts, Poria 10~15 parts, Radix Salviae Miltiorrhizae 10~15 parts, Radix Codonopsis 10~15 parts, Chinese holly
Qi 10~15 parts, Radix Polygoni Multiflori Preparata 10~15 parts, Radix Rehmanniae Preparata 10~20 parts, the Rhizoma Atractylodis Macrocephalae 10~20 parts, Fructus Schisandrae Chinensis 10~
20 parts, Fructus Ligustri Lucidi 10~20 parts, Radix Polygalae 10~20 parts, Radix Ophiopogonis 10~20 parts, Radix Trichosanthis 10~20 parts,
Radix Paeoniae Rubra 10~20 parts, Rhizoma Curculiginis 10~20 parts.
The Semen Cuscutae oral liquid of described raising immunity, the weight of various raw materials in its described Semen Cuscutae health tea
Amount number can also be: Semen Cuscutae 10~40 parts, Semen Coicis 10~20 parts, Radix Angelicae Sinensis 10~20 parts, Rhizoma Polygonati 10~
20 parts, Fructus Corni 10~20 parts, Poria 10~20 parts, Radix Salviae Miltiorrhizae 10~20 parts, Radix Codonopsis 10~20 parts, Chinese holly
Qi 10~20 parts, Radix Polygoni Multiflori Preparata 10~20 parts, Radix Rehmanniae Preparata 10~15 parts, the Rhizoma Atractylodis Macrocephalae 10~15 parts, Fructus Schisandrae Chinensis 10~
15 parts, Fructus Ligustri Lucidi 10~15 parts, Radix Polygalae 10~15 parts, Radix Ophiopogonis 10~15 parts, Radix Trichosanthis 10~20 parts,
Radix Paeoniae Rubra 10~20 parts, Rhizoma Curculiginis 10~20 parts.
For solving above-mentioned technical problem, the present invention also provides for a kind of Semen Cuscutae health tea improving immunity
Preparation method, the preparation process of its described Semen Cuscutae health tea includes following aspect:
A. the screening of Semen Cuscutae, dry in the sun;
B. the Semen Cuscutae dried well is fried, steep and become extractum into ethanol extraction, become component 1;
C. other raw material soaking ethanol heating extraction described are become extractum, for component 2;
The most again above two component is merged, be condensed into after pasty state adds Mel or dextrin mediation canned.
In described step a, together can cut off with host at ripe Semen Cuscutae fruit of gathering in 9~October,
Dry, lay seed, decontamination of winnowing with a dustpan, clean, dry.
In described step b, the Semen Cuscutae that dry in the sun is good can be put in the pot that completes and go green grass or young crops, at 70-100 DEG C
Complete 30-45 minute, stir-fry in being then placed in big iron pan, start to stir-fry 20-30 minute, after taking-up certainly
The most shady and cool;The Semen Cuscutae that dry in the sun is good is steeped in 10 times amount ethanol after 10-15 days, heating extraction 2 times, often
Secondary 1-2 hour, removing supernatant, united extraction liquid, 100-110 mesh filters, then through the molecular weight that dams is
The ultrafiltration post ultrafiltration of 6000-10000, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C,
Heating is concentrated into paste, stand for standby use, becomes component 1.
In described step c, can take in the ethanol that other starting material left raw materials steep 5-10 times amount, soak 1-2
Hour, heating extraction 2 times, each 1-2 hour, united extraction liquid, removes supernatant, then puts after standing
Entering in concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, and sucking filtration is to filter
The extractum of 1.06 when the relative density of liquid is 20 DEG C, becomes component 2.
In described step d, can the extractum that above-mentioned steps obtains be inserted in economic benefits and social benefits vacuum concentrator, dense
Being reduced to relative density when 90 DEG C is the concentrated solution of 1.05, sets to 0~5 DEG C of deepfreezes 24 hours;By cold preservation liquid
The filter aid kieselguhr adding 0.3%, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml
Containing 1g crude drug amount;Unguentum after concentration adds Mel mediation and makes oral liquid.
For solving above-mentioned technical problem, the present invention reoffers a kind of Semen Cuscutae health tea improving immunity
Preparation method, its preparation process can also be:
A. the preparation of Semen Cuscutae, as component 1;
B. remaining crude drug described chopping is extracted as component 2;
C. component 1 and component 2 are mixed, add proper honey after concentration and be in harmonious proportion, fill after ultraviolet ray sterilization bactericidal
Bottle.
In described step b, remaining raw medicinal material can be mixed, shred 100~120 mesh sieves, and sieved
Rear fine powder is standby, and coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, soaks together with more than 70 degree ethanol
Stain 15~30 days, then heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution are merged and stands,
Filter, after separation, take filtrate;By filtered through gauze, adding 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued
Continuous extraction 2h, every 10min stir once, and filtered through gauze merges lixiviating solution, and being condensed into pasty state becomes group
Divide 2.
Useful the having technical effect that of the present invention, Semen Cuscutae is listed in top grade in Shennong's Herbal.
Its abnormal smells from the patient is pungent, sweet, flat nontoxic.Function with cure mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.It is applicable to Liver and kidney
Not enough waist knee joint muscles and bones is ached, and legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, urine have She
The diseases such as drip, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion;Add again
Upper blood circulation promoting and blood stasis dispelling, the Chinese crude drug of invigorating spleen to remove dampness yin nourishing, the most mouthfeel of these medical materials is light, does not affects
The taste of Semen Cuscutae tea, does not has the unpleasant taste of Chinese medicine being difficult to and swallowing, and makes people be prone to accept, can substantially carry
High immunity, can preferably improve sub-health population easy catching a cold, eyes are sour and astringent, sleep quality is the highest, spleen
Empty weak;Lack of appetite xerostomia;Quench one's thirst;Deficiency of the kidney soreness of the waist and knees;Impotence and seminal emission;Tinnitus mesh is dark;Early whitening of beard and hair;
Body void is won thin;The symptom of wind favus disease, can preferably reach to improve effect of immunity.
Detailed description of the invention
Human immunity is the defensive enginery of human body pathogenic microorganism etc. to external world, or perhaps defence system
System, under normal circumstances, it ensure that human body is not encroached on by extraneous pathogenic microorganism.Generally say
Body immunity refers to the immune system of human body and resists the ability that exotic disease pathogenic microorganism etc. is encroached on.People
In the case of body immunity is normal, human body self can resist the infringement of considerable pathogenic bacteria, it is to avoid to people
Body causes damage.Immunity plays an important role in human life mechanism, and the nutrition of human body, labor
Tired, mood, environment, disease, medication, radiation etc. cause the immunity degradation of self.Get more and more and grind
Studying carefully and show, the regulation of body immunity is increasingly played a significant role by Chinese medicine.
Due to economic prosperity day by day, the continuous lifting of modern's living standard, cause the heat that people are too much
It is a lover of pleasure, does not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.
Society with fast rhythm lives, and the physical and mental health of modern is caused seriously by the operating pressure of keen competition
Threat, make people more than half be in sub-health state, show themselves in that dizziness, nervous, weak, food
Being intended to depressed, hypomnesis, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, it may be assumed that
Essence grain replaces coarse grain completely, substantial amounts of three-hypers (high heat, high protein, higher fatty acid), more than three (preservative
Many, flavour enhancer is many, hormone many) pesticide of residual, chemical fertilizer depositing in vivo in the absorption of food and food
Long-pending, it is less than normal to add air, pollution of waterhead and quantity of motion, goes down to make three-hypers disease (high blood for a long time
Pressure, hyperglycemia, hyperlipidemia), cardiovascular and cerebrovascular disease, cancer etc. so-called " modern civilization diseases " go up rapidly
Rise, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.A variety of causes makes siberian crabapple
System can not normally play protective effect, in the case, easily causes antibacterial, virus, fungus etc. and infects,
Therefore hypoimmunity the most directly shows is exactly liable to illness.Because of the most ill, increase the weight of disappearing of body
Consumption, thus typically have a delicate constitution, malnutrition, lethargy, fatigue and weak, appetite reduce, sleep
Dormancy obstacles etc. show, sick, having an injection to take medicine has become homely food.The most sick will for a long time
Can recover, and usually recurrent exerbation.Health and intelligent development if things go on like this can be caused bad, the most easily lure
Send out major disease.Underlying causes be hypoimmunity or immunity unsound.When immune function of human body is lacked of proper care,
Or when immune system is unsound, following point will recurrent exerbation: flu recurrent exerbation, tonsillitis
Recurrent exerbation, asthma recurrent exerbation, bronchitis recurrent exerbation, pneumonia recurrent exerbation, diarrhoea are sent out repeatedly
Make.So necessarily can't neglect.
" Semen Cuscutae ", has another name called SEMEN CUSCUTAE, Herba cuscutae real, without ma rattan, dodder laurel, Tu rattan, Tu thread, open country Vulpes
Silk, bean parasitism, Caulis Fibraureae, trailing plants SIZI etc., for the seed of convolvulus cuscuta plant.Have " continuous wound absolutely,
Tonifying for the deficiency, the strong people of benefit " merit.The effect that " Mingyi Bielu " calls it to be had " supporting flesh reinforcing YIN-essence, hard muscles and bones ".Ancestral
State's medical science is thought, Semen Cuscutae acrid-sweet flavor, and property is put down, and enters liver, kidney two warp.There is the kidney invigorating and essence nourishing, nourishing the liver bright
Mesh, antiabortive effect.Can be used for soreness of waist and knee joint, sexual impotence, premature ejaculation, seminal emission, the enuresis, frequent micturition She drip,
Tinnitus, dizziness dim eyesight, visual deterioration, threatened abortion, the inferior disease of band..
" book on Chinese herbal medicine converges and says ": " warming the spleen helps the medicine of stomach also for Semen Cuscutae, tonifying kidney and nourishing liver.But mend and the highest, temperature
And the driest, therefore enter kidney channel, void can be mended, in fact can be in order to, cold can temperature, heat can be cool, wet can be dry,
Dry can moisten.If non-Cortex Phellodendri, the Rhizoma Anemarrhenae, bitter cold and the warmest, have the gas rushing down kidney channel;If non-Cortex Cinnamomi, Fructus Alpiniae Oxyphyllae,
Hot and the coolest, there is the dry of kidney channel;If non-Herba Cistanches, trivial sun, sweet one-tenth and stagnant gas, there is the wet of raw kidney channel
Person's ratio is also.Hinder absolutely as " legendary god of farming's book on Chinese herbal medicine " is referred to as continuing, physical strength profiting, improving eyesight essence, all by tonifying kidney and nourishing liver, temperature
Levying of taste of reason is tested also.″
" book on Chinese herbal medicine is newly organized ": " Semen Cuscutae, can reuse, also can be the most special.The people that chance is had a guilty conscience, day and night
Dream, the essence frequency person of letting out, with Semen Cuscutae three liang, ten bowls of water, liquor three bowls, point three clothes, early, noon, evening each
One clothes i.e. stop.And lose the most again.This be the heart, liver, kidney three through neat sick, extreme misery two is empty caused.Semen Cuscutae
Positive reinforcing the heart, liver, the panacea of kidney, the other taste that condition is the most miscellaneous, then power is especially special, so three can directly be entered through to receive
Full effect is also.He is as uneasy in night dream, and two blurred visions are dark, and biped is weak, one of all can use, two liang, same to Radix Ginseng,
Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, mountain sprout etc, with more than make outstanding contributions.″
" herbal classic is met former ": " Liver and kidney edema caused by disorder of QI is also for Semen Cuscutae, dispelling pathogenic wind for improving eyesight.Its property and flavor of peppery and warm matter is glued, with
The strong muscle of the Cortex Eucommiae warms up waist knee joint and is as good as.Its merit specially in benefit marrow, hard muscles and bones, only spermatorrhea, stem essence of trembling with fear goes out,
Drown have She to drip, go knee joint soreness of the shank soft, old man's Liver and kidney deficiency of vital energy, lumbago knee joint is cold, close Fructus Psoraleae, the Cortex Eucommiae with it,
All fascias come under liver also.Deficiency of vital energy gb 1, without god person, helps it with Radix Ophiopogonis, and honeyed pill takes, effect.All postcoital protrusion
Not flaccidity, constipation due to dry stool, little water red puckery person not use, the most supporing yang also with its property.″
" book on Chinese herbal medicine justice ": " Herba cuscutae is that yin nourishing dredging collateral is top grade.Its taste is micro-pungent, then have sun in the moon, keep and energy
Walking, the relatively greasy stagnant person of medicine all with other YIN nourishing is the most different.Among Miao's secondary alcohol meaning five tastes, pungent logical four gas, " warp "
Yan Xin is to moisten it, and the genus of Semen Cuscutae is also, and scorching with pungent perfume (or spice) is pungent, and widely different different, institute's solution is the most true and pertinent.
" herbal classic " continuous wound absolutely, tonifying for the deficiency, physical strength profiting, fertile strong people, among nourishing, all there are logical hundred arteries and veins of a surname,
The meaning of Wen Yunyang sum.Juice goes to face, the function of the most soft and moist skin.Long clothes then cloudy liquid is sufficient and mesh is self-evident." not
Record " the so-called strong flesh of yin nourishing, hard muscles and bones, the also justice of negative and positive two tune.The cold essence of stem is sliding, then Yuanyang is uncomfortable and arrive
The moon is not taken the photograph yet, drown have She to drip, then kidney yang not cloth and air is not lifted yet.Dry yearningly with regard to bitter taste, bright is cloudy liquid
Dry up, cold blood becomes long-pending, also not declaring for yang-energy, only this kind YIN nourishing liquid and compress sun and, circulate hundred
Arteries and veins, so controlling it.To keep regarding the special of Radix Rehmanniae generation in nourishing YIN and not walk person, intrinsic.″
Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For the moon
Through uncomfortable, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, vexed not
Sleep.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia,
Amenorrhea dysmenorrhea, puerperal the stasis of blood pain etc..Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, through amenorrhea
Pain has good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy,
Paying no attention to antenatal puerperal, how many through water, the most generally applicable, only taste Radix Salviae Miltiorrhizae dissipates, and cures mainly same.Gai Dan
Ginseng can break stagnated blood, mends fresh blood, and peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Radix Salviae Miltiorrhizae mainly becomes
Point TANSHINONES has expansion blood vessel, improves circulation, releases the effects such as intravascular coagulation, have invigorating blood circulation trace it
Effect, and can promote that liver blood circulates, beneficially liver cell regeneration.
Poria sweet in the mouth, light, property are put down, and are used as medicine and have promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming.
Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver
Dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, rather
Effect of heart and tranquilizing mind.Dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis can be controlled, have loose bowels,
Seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function,
Different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis,
For having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, often and Radix Codonopsis,
The compatibility such as the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.
Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, for clearing away heat-fire class medicine, its tool
Body effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, and evacuation of pus is subsided a swelling.Cure mainly: control that calentura is thirsty, quench one's thirst, jaundice,
Dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.For treatment diabetes, conventional it with drugs for nourishing yin with the use of, to reach
Effect to treating both the principal and secondary aspects of a disease." book on Chinese herbal medicine converges and says ": Radix Trichosanthis, moves back the five internal organs hot and suffocating, as heart-fire is contained and dry tongue
Dry mouth, lung-fire contain and pharyngeal swelling sore throat, spleen-fire contain and dispute tooth swell, phlegm-fire contain and cough the most peaceful.If liver-fire
The swollen migratory arthralgia caused by wind of the side of body, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle do not bursts, and pyretic toxicity does not dissipates, or five types of jaundice body mesh
All yellow, and if if little water drenches puckery, be caused by all burning hot pent-up, only this agent energy relieving stagnation, phlegm-fire drops, and
Can be controlled it.Its property is sweet cold again, kind can control thirsty, controls from tonic empty thirsty, controls fire from the medicine of a cold nature thirsty, from gas
Medicine and control and strongly fragrant yearningly control excessive thirst from blood medicine, be to control thirsty key medicine also.
Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, peace
Tire.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae pair
Oncocyte has cytotoxicity, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves
The ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil to mice ehrlich carcinoma, lymphosarcoma ascitic type,
Esophageal carcinoma Eca109), sarcoma 180 etc. have inhibitory action.Atractylodes lactone B lumbar injection is to murine sarcoma
The people.Also effect is significantly inhibited." property of medicine opinion " carries it: monarch, and sweet in the mouth is pungent, nontoxic.Can main strong wind
Numbness, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, remove sputum, except cold and heat, let out under stopping.Main
Face light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells vomiting, cold type of pain in abdomen, vomits and diarrhoea incessantly, and gastric qi
Cold caused by deficiency dysentery.
Rhizoma Polygonati is used as medicine with rhizome.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.For treating spleen
Insufficiency of stomach is weak, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, and interior-heat such as is quenched one's thirst the disease.For
Diabetes are the most effective in cure.Stir-baked RHIZOMA POLYGONATI with yellow rice wine is also known as processing Rhizoma Polygonati.Cut into slices after steaming with the adjuvant such as wine and Semen sojae atricolor for clean Rhizoma Polygonati
Dry the person of being used as medicine.Have the merit of meridians of escaping concurrently.Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, blood fat reducing, anti-stop
Pulse atherosclerosis, slow down aging and antibacterial etc. acts on, and polygonatum polysaccharide has Immunestimulatory effect.For the moon
The empty dryness of the lung, the few expectorant of dry cough, and the chronic cough chronic cough etc. of YIN-deficiency of the lung and kidney.For weakness of the spleen and stomach.Both tonifying spleen-yin,
Strengthening the spleen gas again, obtains dizzy for deficiency of kidney essence, soreness of the waist and knees, early whitening of beard and hair and quenching one's thirst.Rhizoma Polygonati strengthens muscle
Bone, benefit marrow, bleach and send out;It is suitable for the cough expectorant caused by lack of lung-YIN few, dry cough without phlegm, hemoptysis
Deng disease.
Fructus Corni sour in the mouth, adstringency, tepor.Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming.For dizzy
Dizzy tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapses, and interior-heat is quenched one's thirst,
For astringent drug, it contains cornin, not sieve glycoside, 7-O-methyl not sieve glycoside, Cornuside, works as medicine
The iridoid glycosides such as glycoside, loganin and Saponin, ursolic acid, tartaric acid, gallic acid, malic acid,
The multiple active ingredients such as Fructus Corni tannin 1,2,3.There are obvious diuresis, blood fat reducing, antibacterial and rising blood
The effect of liquid leukocyte, to the vertigo and tinnitus caused by treatment deficiency of both the liver and kidney, the disease such as the soreness of waist and due to kidney yin not
The diseases such as seminal emission caused by foot, frequent micturition have obvious curative effects.It is usually used in woman again because it has astringing to arrest bleeding effect
Menorrhagia caused by female's body void, the disease such as bleeding not during menses, the commonly encountered diseases of andrology, gynecological is all had well
Therapeutical effect, is largely used to the production of tonification medicine, therefore is listed in one of 40 kinds of large kinds of traditional Chinese medicines,
Market widely is had at Chinese medicine circle.
Fructus Schisandrae Chinensis temperature;Sour, sweet;Return lung, the heart, kidney channel;Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.
For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty,
Losing heart deficient pulse, interior-heat is quenched one's thirst, palpitation and insomnia." Bencao Jingshu " carries: the main QI invigorating person of Fructus Schisandrae Chinensis, lung master
All gas, acid can be received, and is just entering lung tonifying the lung, therefore QI invigorating is also.Its main cough with dyspnea person, the deficiency of vital energy then upper heap soil or fertilizer over and around the roots and not
Gui Yuan, sour flavor having the property of astringing, to take the photograph gas and return unit, then cough with dyspnea is from removing.Impairment caused by overstrain is won thin, tonifying for the deficiency, reinforcing YIN-essence,
Benefit man's essence." not Lu " supports the five internal organs, heat extraction, flesh person in raw the moon, the special the kidney invigorating of Fructus Schisandrae Chinensis, tonifying five ZANG-organs of holding concurrently,
Kidney storing essence, essence is contained then cloudy strong, and receipts are taken the photograph, and vital qi returns unit, and public region is warmed up, digesting food, steams waste matter and changes
Precise and tiny, the most smart spontaneous, essence is raw then cloudy long, therefore the most all main diseases are also.
Radix Codonopsis is traditional tonic that China is conventional, and ancient times are upper with the Radix Codonopsis that area, Shangdang, Shanxi produces
Product, have invigorating the spleen and replenishing QI, effect of strengthening spleen and tonifying lung.Modern study, Radix Codonopsis containing various saccharides, phenols,
Sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, have enhancing immunity, expansion
Open blood vessel, blood pressure lowering, improve the effect such as microcirculation, enhancing hemopoietic function.In addition chemotherapy radiotherapy is caused
Leukopenia has castering action.Radix Codonopsis has invigorating the spleen and replenishing QI, effect of strengthening spleen and tonifying lung.For the spleen deficiency of the lung
Weak, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst." Bencao Congxin " is recorded: " mend
Middle QI invigorating and taste, relieving thirst and restlessness.Middle feeble QI is weak, in order to adjust benefit, the most smooth and proper.”
Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, boils with Semen sojae atricolor
Juice dries after mixing steaming and is used as medicine for Radix Polygoni Multiflori Preparata.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle,
Loosening bowel to relieve constipation, is usually used in treating scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation;Radix Polygoni Multiflori Preparata function invigorating the liver and kidney,
Benefiting essence-blood, crow beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees,
Numb limbs and tense tendons, bleeding not during menses, chronic malaria body are empty.Radix Polygoni Multiflori Preparata of the present invention is the good of invigrating kidney
Product.
Radix Angelicae Sinensis, its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, invigorating middle warmer has,
Row has benefit, the gas medicine in sincere blood, the also panacea in blood.About then the mending to mend of assistant, therefore can support nutrition
Blood, QI invigorating spermatogenesis, settling five organs, strong body, benefit mind, all tangible deficient diseases, unsuitable without institute.Assistant
To attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, control contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and
Exterior syndrome being not relieved person, assistant, with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, can dissipate greatly Biao Weire, and person do not held back by table, and assistant is with greatly
Yellow etc, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore be intended to its quiet person and ought keep away it, the sliding benefaction of property, stool is not
Gu person is when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, the most non-preferably, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis energy
Nourish blood, be indispensable.
Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, and belongs to goatweed, is a kind of first-class Chinese crude drug, has and enrich blood
YIN nourishing effect, can be used for blood deficiency and yellow complexion, dizziness, palpitation and insomnia, menoxenia, the disease such as metrorrhagia, also may be used
For deficiency of kidney yin hectic fever hectic fever due to YIN-deficiency, night sweat, pass out semen, the disease such as quench one's thirst, be deficiency syndrome class nonprescription drugs medicines
One of LIUWEI DIHUANG WAN main component.This quality is moistened into kidney, and kind nourishing kidney yin, life essence-filling, marrow-benefitting, for the kidney invigorating
The key medicine of the moon.Ancients call it " big tonifying five ZANG-organs is Kidney-Yin ", " the true water of big benefit ".Often it is equal to Rhizoma Dioscoreae, Fructus Corni
With, treat the hepatic and renal YIN deficiency, soreness of the waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst, can tonifying liver
Kidney, benefit marrow, such as LIUWEI DIHUANG WAN.
Fructus Lycii: sweet, flat.Folium Lycii: bitter, sweet;Cool in nature.Function: Fructus Lycii: nourishing the liver, nourishing kidney,
Lung moistening.Folium Lycii: qi-restoratives benefit essence, clearing away heat to improve acuity of vision.Lycium barbarum polysaccharide is a kind of water soluble polysaccharide, is Fructus Lycii
In topmost active component, relative molecular mass is 68-200, becomes domestic and international study hotspot.Wherein
Again with immunomodulating and the most study of antitumor action of lycium barbarum polysaccharide.There is now a lot of research and show Chinese holly
Qi polysaccharide has promotion immunity, defying age, antitumor, removing free radical, resisting fatigue, radioprotective, guarantor
The effects such as liver, reproductive function protection and improvement.
Fructus Ligustri Lucidi is for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and the moon
Shoot without hitting the target hot.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly take effect.Control poor vision, often join
Radix Rehmanniae Preparata, Fructus Lycii equivalent use, control early whitening of beard and hair, often join the same use of Fructus Mori, fever due to yin deficiency, often join Cortex Lycii.
The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia,
Hypertension, chronic hepatitis.Protective effect research to liver is thought, Fructus Ligustri Lucidi contains oleanolic acid,
To rat skin lower injection, it is possible to decrease serum glutamic pyruvic transminase, the hepatic injury to Carbon Tetrachloride Induced has substantially
Protective effect, and liver cell regeneration can be promoted. oleanolic acid also can make triglyceride accumulation in liver reduce,
Hepatocellular degeneration necrosis substantially alleviates, glycogen accumulation increases, serum γglobulin declines;Ultrastructure can
See hepatocyte mitochondrial swelling and endosomal vesicle degeneration alleviate, hepatic tissue interstitial inflammation habituation.
Radix Polygalae is bitter, pungent, tepor.GUIXIN, kidney, lung meridian.Function cures mainly Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm, detumescence.
The insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin,
Breast swell and pain.It is applied to insomnia and dreamful sleep, severe palpitation, forgetful.This product toil is warm in nature, property is kind lead off logical
Reach, can happily gas and mind tranquilizing and the heart calming, kidney qi can be led to and strong will is not forgotten, for restoring normal coordination between the heart and kidney, stable god
The good merchantable brand that will, Fructus Alpiniae Oxyphyllae are known by force.Cure mainly disarmony between the heart and kidney malaise, have a sleepless night, the disease such as palpitation with fear, often and Fu
The same use of medicinal for tranquilizing mind such as god, Dens Draconis, Cinnabaris, such as Radix Polygalae ball (" Zhang Shi doctor is logical ");Control forgetful card,
Often and Radix Ginseng, Poria, the same use of Rhizoma Acori Graminei, such as Kaixin San (" prescriptions worth thousand gold "), if Fang Zhongzai adds Poria cum Radix Pini,
Do not forget to dissipate (" Standards of Diagnosis and Treatment ")." book on Chinese herbal medicine is just ": Radix Polygalae, the wholwe-hearted kidney of merit, therefore can relieving palpitation spasmolytic,
The peace that exorcises evil spirits dream, Yang strengthening and life essence tonifying, strong will power-assisted.With its gas lift, therefore same Radix Ginseng, Radix Glycyrrhizae, Semen Ziziphi Spinosae, pole energy
Lift and fall into consolidating semen, join extreme misery.
Radix Ophiopogonis nature,taste and action: hardship sweet, micro-, cool, Yin-nourishing and body fluid promoting, nourishing the lung to arrest cough, clear away heart-fire relieving restlessness.Cure mainly
Consumption of body fluid caused by febrile disease, vexed, thirsty, dry pharynx lung-heat, cough, pulmonary tuberculosis.Joining Radix Adenophorae (Radix Glehniae), lung stomach is ruled together, tool
There is the cool stomach of lung heat clearing, the good effectiveness of YIN nourishing and the production of body fluid promoting is few for the dry cough caused by lung-dryness syndrome due to deficiency of YIN or thermal burn lung yin
Expectorant, the disease such as dry laryngopharynx.Joining Fructus Schisandrae Chinensis, sour and sweet drugs can transforme into YIN, keeping the moon so staying sun, sun stays antiperspirant from only.Merit
Can yin nourishing arresting sweating, with controlling deficiency of YIN hyperhidrosis, cardiopalmus, chronic cough of deficiency lung, lack expectorant or expectorant and glue not well etc..
Radix Paeoniae Rubra is bitter, is slightly cold.Return Liver Channel.Attending effectiveness: clearing away heat and cooling blood;Blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen;
Hematemesis and epistaxis;Discharging fresh blood stool;Conjunctival congestion and swelling pain;Carbuncle skin infection;Amenorrhea;Dysmenorrhea;Metrorrhagia and leukorrhagia stranguria with turbid discharge;The stasis of blood is stagnant
Hypochondriac pain;Hernia abdominal mass is gathered;Injury from falling down.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, stagnation of liver-QI is coerced
Bitterly, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection." herbal classic ": main pathogen is suffered from abdominal pain,
Except arthralgia due to stagnation of blood, broken heavily fortified point is long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." not Lu ": clear and coherent blood vessels,
In Huan, dispelling malignant blood, expelling extravasated blood, go aqueous vapor, profit bladder intestine and small intestine, subduing inflammation, time row cold and heat, attacked by pestiferous factors
Stomachache, lumbago." property of medicine opinion ": control pathogen of the lung gas, lump pain in abdomen, vim and vigour are gathered, and lead to a surname's internal organs and gather around gas,
Controlling evil pain deteriorated blood, time main, disease bone heat, strong the five internal organs, the kidney invigorating gas, control trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed,
Repercussive blood, can lose pus.
Rhizoma Curculiginis has reinforcing the kidney and supporting YANG, benefiting essence-blood, bone and muscle strengthening and the effect of promoting the circulation of blood detumescence, is mainly used in kidney yang
The diseases such as deficiency, impotence and seminal emission, chronic consumptive disease internal injury and bones and muscles pain.Modern pharmacology activity research display Rhizoma Curculiginis
Have regulation immunity, antioxidation, protect the liver, hyperglycemia, kidney invigorating and YANG supporting and osteoporosis, antiinflammatory and
Adapt to the effects such as former state.
Semen Coicis is conventional Chinese medicine. being again food universal, that often eat, property slightly sweet flavor is slightly cold, and has diuretic to disappear
The effects such as swollen, spleen invigorating is dried, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus, for conventional damp-clearing drug.Semen Coicis is again
Being a kind of beauty food, often food can keep human body skin gloss fine and smooth, eliminates acne, speckle passeris montani saturati, old age
Speckle, cyasma, butterfly spot, to desquamation, acne, chap, pachylosis etc. has good efficacy.The heart of a lotus seed
The kind Renhe root of rice can be used as medicine again and cure the disease." spleen invigorating benefit that Li Shizhen (1518-1593 A.D.) is described in Compendium of Material Medica: Semen Coicis energy
Stomach, tonifying the lung heat clearing away, remove wind prevailing over dampness.Cook a meal food, control cold air.Decoct drink, diuresis pyretic stranguria." in recent years,
Substantial amounts of scientific research and clinical practice prove, Semen Coicis or a kind of cancer therapy drug, Preliminary Identification, it is right
The suppression ratio of cancer is up to more than 35%.
Specific embodiment 1:
First Semen Cuscutae is screened, dry in the sun;
Again Semen Cuscutae is fried, steep into ethanol, extract, as component 1;
Again by remaining raw material Semen Coicis, Radix Angelicae Sinensis, Rhizoma Polygonati, Fructus Corni, Poria, Radix Salviae Miltiorrhizae, Radix Codonopsis, Fructus Lycii,
Radix Polygoni Multiflori Preparata, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, Radix Polygalae, Radix Ophiopogonis, Radix Trichosanthis, Radix Paeoniae Rubra, Rhizoma Curculiginis
Extract, as component 2;
By two kinds of component mixing, add Mel or dextrin mediation ultraviolet radiation for sterilizing and disinfecting bottling.
Specific embodiment 2:
Maturation of gathering in 9~October Semen Cuscutae fruit, together cuts off with host, dries, lay seed,
Winnow with a dustpan decontamination, clean, dry.About 5000g, puts into the Semen Cuscutae that dry in the sun is good in the pot that completes and goes green grass or young crops,
Completing at 70-100 DEG C 30-45 minute, stir-fry in being then placed in big iron pan, the 20-30 that starts to stir-fry divides
Clock, naturally shady and cool after taking-up;The Semen Cuscutae that dry in the sun is good is steeped in 10 times amount ethanol after 24 hours, heating
Extracting 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-110 mesh filters, then through damming
Molecular weight is the ultrafiltration post ultrafiltration of 6000-10000, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36
Extractum, heating is concentrated into paste, and stand for standby use becomes component 1.
Take other raw materials Semen Coicis 1500g, Radix Angelicae Sinensis 1500g, Rhizoma Polygonati 1500g, Fructus Corni 1500g, Poria again
1500g, Radix Salviae Miltiorrhizae 1500g, Radix Codonopsis 1500g, Fructus Lycii 1500g, Radix Polygoni Multiflori Preparata 1500g, Radix Rehmanniae Preparata 1500g, in vain
Art 1500g, Fructus Schisandrae Chinensis 1500g, Fructus Ligustri Lucidi 1500g, Radix Polygalae 1500g, Radix Ophiopogonis 1500g, Radix Trichosanthis 1500g,
Radix Paeoniae Rubra 1500g, Rhizoma Curculiginis 1500g, add in the ethanol of 5-10 times amount and soak 24 hours, heating extraction 2 times,
1-2 hour every time, removing supernatant, united extraction liquid, 100-120 mesh filters, then through the molecular weight that dams is
The ultrafiltration post ultrafiltration of 5000-10000, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C,
Heating is concentrated into paste, stand for standby use, becomes component 2.
Two kinds of components are inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C relative density be 1.05 dense
Contracting liquid, sets to 0~5 DEG C of deepfreezes 24 hours;The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters,
Filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 1g, then adds Mel and is in harmonious proportion,
Become oral liquid.
Specific embodiment 3:
Maturation of gathering in 9~October Semen Cuscutae fruit, together cuts off with host, dries, lay seed,
Winnow with a dustpan decontamination, clean, dry.About 4000g, steeps the Semen Cuscutae that dry in the sun is good in 10 times amount ethanol
After 24 hours, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-110
Mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 6000-10000 through damming, and ultrafiltrate concentrating under reduced pressure is relative
The extractum of 1.36 when density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 1;Take other
Raw material Semen Coicis 1200g, Radix Angelicae Sinensis 1300g, Rhizoma Polygonati 1200g, Fructus Corni 1100g, Poria 1200g, Radix Salviae Miltiorrhizae
1200g, Radix Codonopsis 1200g, Fructus Lycii 1200g, Radix Polygoni Multiflori Preparata 1100g, Radix Rehmanniae Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1200g, five
Taste 1200g, Fructus Ligustri Lucidi 1200g, Radix Polygalae 1200g, Radix Ophiopogonis 1100g, Radix Trichosanthis 1200g, Radix Paeoniae Rubra 1200g,
Rhizoma Curculiginis 1200g, take crude drug clean dry;Soak in water 12 hours, be then placed in extraction pot heating and boil
Boiling 1 hour, filter, filtrate is standby;Filtering residue adds water, second time heating, boils 45 minutes, filters,
Filtrate is standby;Filtering residue adds water, for the third time heated and boiled half an hour, filters;Three filtrates are combined in one
Rising, powder is placed in 70-90% ethanol immersion 1-2 hour, is heated to 60 DEG C-70 DEG C in water-bath, extraction
2h, every 10min stir once, by filtered through gauze, add 50-60% ethanol, 60 DEG C-70 DEG C continuation in residue
Extraction 2h, every 10min stir once, and filtered through gauze merges lixiviating solution, is condensed into pasty state, becomes component 2;
Component 1 and component 2 are mixed.Then add Mel to be in harmonious proportion, make oral liquid;Ultraviolet disinfection, packaging is i.e.
?.
Specific embodiment 4:
Maturation of gathering in 9~October Semen Cuscutae fruit, together cuts off with host, dries, lay seed,
Winnow with a dustpan decontamination, clean, dry.About 3500g, then take other raw materials Semen Coicis 1200g, Radix Angelicae Sinensis 1300g,
Rhizoma Polygonati 1200g, Fructus Corni 1100g, Poria 1200g, Radix Salviae Miltiorrhizae 1200g, Radix Codonopsis 1200g, Fructus Lycii 1200g,
Radix Polygoni Multiflori Preparata 1100g, Radix Rehmanniae Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1200g, Fructus Schisandrae Chinensis 1200g, Fructus Ligustri Lucidi 1200g, Radix Polygalae
1200g, Radix Ophiopogonis, all raw materials were put by 1100g, Radix Trichosanthis 1200g, Radix Paeoniae Rubra 1200g, Rhizoma Curculiginis 1200g
Enter in 10 times amount ethanol, heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution are merged and stands;
The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction again add 10 times amount water heating and refluxing extraction 2 times,
Each 1~2 hour, 2 extracting solution are merged and stands;Above two extracting solution is merged, concentrating under reduced pressure
Relative density is the filtrate of 1.35 (80 DEG C), reclaims ethanol, by gained filtrate adjustment proportion to 1.06, subtracts
Press to obtain extractum, then add Mel and be in harmonious proportion, city oral liquid, ultraviolet disinfection, pack and get final product.
Pharmacological toxicity is tested
One, test material:
(1) laboratory animal: mouse NIH, body weight 25-28g, male and female half and half;Rats Wistar body weight
130-160g, male and female half and half, rat, the feedstuff of mice are provided by Shandong medical college animal experimental center.
(2) test medicine:
1, medicine of the present invention: the oral liquid that embodiment 2 is made, steams during three batch equal amount of mixture experiments
Distilled water dilution application.
2, positive control medicine: JINGUI SHENQI WAN, commercially available.
Two, test method and result:
(1) healthy mice 80 of body weight 25-28g is taken, female, male half and half, it is respectively classified into by sex and body weight
Four groups, often group 20.1, taking medicine of the present invention for 2,3 groups, dosage is respectively 8.6g crude drug/kg/d, 6.4g
Crude drug/kg/d, 4.2g crude drug/kg/d, takes positive control drug JINGUI SHENQI WAN for the 4th group, and dosage is 6g crude drug
/ kg/d, is used in conjunction 15 days.
Result of the test: 1,2,3 groups of mices are remarkably reinforced than 4 groups of mice sexual excitation degree, 1,2,3 groups little
The number of copulations of Mus increases by 3 times every day average than the number of copulations of 4 groups of mices.
Result of the test shows that medicine of the present invention has obvious excitation to central nervous system, so this
Invention medicine for regulation function of human body balance, QI invigorating, enrich blood, slow down aging strengthens metabolism, smart
Mental fatigue is exhausted, and sexual hypofunction has treatment foundation.
Animal acute toxicity test of the present invention
One, test material
(1) animal mouse NIH kind male and female half and half, body weight 20-22g, Shandong medical college Animal Lab. carry
Supply.
(2) test medicine: the oral liquid that the present invention is made, is diluted with distilled water into suspension.
Two, test method and result:
Mice maximum tolerance determination: take healthy mice 32, male and female half and half, divided three within 24 hours
Group, each 0.6ml/ of gavage intestinal, gross weight 1.8ml, be equivalent to crude drug in whole 4.0g, i.e. 100g crude drug/kg/d,
Be equivalent to 857 times of clinical 65 kilograms of people.Mice be administered after routinely feedstuff within 12 days, have no animal dead and
Do not go out, show toxic reaction.Hence it is demonstrated that medicine of the present invention has no side effect, clinical practice is safe and reliable.
The long-term toxicity test for animals of pharmaceutical composition of the present invention
One, test material and method
(1) test medicine: the oral liquid that the embodiment of the present invention is made.
(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by property
Not and body weight random packet, four groups, often group 35.1, taking test medicine for 2,3 groups, dosage is respectively
For 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups compare the distilled water to respective volume amount, the equal gavage of rat
Enteral administration, often organizes and is once used in conjunction 6 months, puts to death half, and under She, all death in 12 days is observed in 1/2 drug withdrawal.
Two, test index
(1) general status includes body weight, diet, emotion, movable energy.
(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc. is blood red
Protein quantification counts.
(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.
(4) pathologic diagnosis: take half animal after experimental result and weigh, sacrificed by decapitation, take blood, with
Time solution is treated others for earnest, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.
Three, result of the test: show through rat chronic toxicity test, with heavy dose coloclysis of the present invention six months,
Growth, the body weight of rat is increased, all has no side effect brain, Liver and kidney function.To rat each group
Knit organ, blood circulation does not finds that infringement changes, and medication group compares no significant difference with matched group.Explanation
Medicine of the present invention have warming and recuperating the kidney-YANG, QI invigorating, enrich blood, slow down aging strengthens the drug effect such as metabolism, nothing
Toxicity.
Pharmacological experiment:
To immunoregulation effect
Using Immunology Today theory and technology, Study of Traditional Chinese Medicine is to strengthening and the work of regulation body's immunity
With, this has highly important meaning to illustrating the material base about theory of Chinese medical science.The present invention is by Herba cuscutae
Several natural drugs such as son, Fructus Corni, Fructus Ligustri Lucidi form through scientific compatibility.Existing research finds, this
The function of invention oral liquid adjustable body each system internal organs, all has regulation to immunocyte and immune molecule
Effect.Inquire into now oral liquid of the present invention further with experiment to hypoimmunity mouse immune regulation effect
Molecular immunology mechanism.
1 materials and methods
1.1 instruments are provided by preparation section of the court with reagent oral liquid of the present invention;Primary raw material has: Semen Coicis,
Radix Angelicae Sinensis, Rhizoma Polygonati, Fructus Corni, Poria, Radix Salviae Miltiorrhizae, Radix Codonopsis, Fructus Lycii, Radix Polygoni Multiflori Preparata, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, five
Taste, Fructus Ligustri Lucidi, Radix Polygalae, Radix Ophiopogonis, Radix Trichosanthis, Radix Paeoniae Rubra, Rhizoma Curculiginis, prepare by the method for embodiment 2.
Cyclophosphamide for injection is provided by Hualian Pharmaceutical Co., Ltd., Shanghai.Cytokine detection kits is all purchased from
R&D company of the U.S..Flow cytometer, 2000FCA, U.S. company BD production.
1.2 animal Kunming system male mices 60, in 6-10 week, body weight is 25 ± 2g, real by University Of Qingdao
Test animal Co., Ltd to provide.
1.3 method
1.3.1 Kunming system male mice is randomly divided into 3 groups with packet by Animal Model: blank
Group, model group and medicine group, often group 10.Blank group: in experiment process, normal raising is not appointed
Where is managed;Model group: intraperitoneal injection 100mg/kg cyclophosphamide causes hypoimmunity model, 1
Secondary/d, for three days on end;Medicine group: intraperitoneal injection 100mg/kg cyclophosphamide causes hypoimmunity mould
Type, 1 time/d, for three days on end, and smears administration, 0.1mL/ at the left tibialis anterior of mice in first day in modeling
Only, booster immunization 1 time after a week, dosage is with for the first time.Collecting sample after 4d.
1.3.2, after the mensuration mice of mouse immune shoot formation weighs in, cervical dislocation puts to death mice,
Take thymus, spleen claims its weight in wet base, calculating thymus index and spleen index: thymus index=chest gland weight × 1000
/ body weight;Spleen index=spleen weight × 1000/ body weight.
The mensuration of 1.3.3 mice serum IgG, IgM level presses test kit description method, measures mice
IgG in serum, IgM content.
1.3.4 mouse boosting tissue T lymphocyte and subgroup CD4+ thereof, CD8+ and CD4+/CD8+
Mensuration aseptic take spleen, be placed in fill appropriate without, in Hank ' s liquid plate, gently spleen being ground with tweezers,
Make single born of the same parents' suspension, filter through 200 eye mesh screens, by cell suspension in the complete culture solution of 1mL,
Adjust cell concentration 1 × 109L-1, the spleen fully mixed by 100 μ L carefully with micropipettor is thin
Born of the same parents' suspension is added to the bottom of sample feeding pipe, adds 20 μ L monoclonal antibodies, and low-speed oscillation mixing 3S, room temperature is kept away
Light hatches 30min, after countler-PREP broken red blood cell, and flow cytometer detection T cell
Subgroup content.
1.3.5 the mensuration of mice serum IFN-Y, IL-10 level presses test kit description method, measures
The level of IFN-Y, IL-10 in serum.
The 1.2 all numerical value of statistical procedures all represent with x ± s, use SPSS13.0 statistical software to enter
Row data analysis, compares employing t inspection between group.Using P < 0.05 as statistical significant difference standard.
2 results
The impact of hypoimmunity mouse immune organ is drawn, with Normal group phase by 2.1 by table 1
Ratio, model group Thymus and spleen index significantly reduces, and difference is statistically significant, P < 0.01.With mould
Type group compares, and medicine group mouse spleen index substantially increases, and has statistical significance, P < 0.01, breast
Gland index also increased, but difference is the most notable.
Table 1 present invention on hypoimmunity mouse immune organ weight impact (n=10, mean ±
S)
Compare with Normal group: Δ: P < 0.05, Δ Δ: P < 0.01;Compare with model group: *:
P < 0.05, * *: P < 0.01
The impact of hypoimmunity mouse boosting tissue T lymph subgroup is found out, with normal control by 2.2 by table 2
Group is compared, model group mouse spleen CD4+ cell subsets percentage drop, CD8+ cell subsets percentage
Than rising, having significant difference, P < 0.05, CD4+/CD8+ ratio substantially reduces, and has the most aobvious
Write sex differernce, P < 0.01.And medicine group can substantially be offset cyclophosphamide and destroy the effect of immunity,
There is significant difference, P < 0.05.
Table 2 present invention on hypoimmunity mice body fluid T cell subgroup impact (n=10, mean
±SD)
Compare with Normal group: Δ P < 0.05, Δ Δ P < 0.05;With than model group: * P < 0.
05, * * P < 0.05.
3 conclusions
Thymus, spleen are the important lymphatic organ of body.Thymus is that T cell is grown, differentiation, ripe
Place, its structure and function are closely related with fuselage state.The reduction of thymus index and atrophy of thymus gland,
It it is all the mice immunosuppressant performance based on cellular immunization.Spleen is the periphery immunity device of internal maximum
Official, the immunocyte of spleen is based on bone-marrow-derived lymphocyte, and bone-marrow-derived lymphocyte is the master participating in humoral immunization
Wanting cell, therefore spleen and humoral immunity of organism is in close relations.Thymus index and spleen index are the most anti-
Answer the power of immune body function.This experiment shows, oral liquid of the present invention is to caused by cyclophosphamide immunity
The growth of the low mouse spleen of power has facilitation, and the growth to thymus also has certain facilitation.
T lymphocyte can be divided into two subgroups of CD4+ and CD8+ by its function.CD4+T lymph
Cell is in very important Central Position in the immunoreation of body, it by secrete multiple lymph because of
Son activates other T, B cell subgroup and participates in other cells immunoreactive so that it is breeds and breaks up,
And coordinate the interaction between immunocyte, play the function of body immune system.CD4+/CD8+'s
Ratio rises, and the just regulation of prompting immunne response is preponderated, and ratio declines, and points out immunologic hypofunction.
This experiment, by the mensuration of t lymphocyte subset group in human peripheral blood, shows that the present invention can make ring phosphorus
The percentage composition of hypoimmunity mice CD4+T lymphocyte caused by amide raises, and makes CD4+/CD8
+ ratio rise, prompting the present invention T lymphocyte immunity system is played positive control.IgG、IgM
Level then reflects humoral immunization ability.The study show that the present invention promote hypoimmunity mouse IgG,
IgM secretes increase.Illustrate that the present invention not only promotes the enhancing of Immune Function, simultaneously to body
Liquid immunity also has facilitation.
Herein by observing the present invention impact on multiple immune indexes, it was demonstrated that the present invention can improve ring phosphinylidyne
The humoral immune function of hypoimmunity model mice caused by amine and cellular immune function, it is possible to correct T and drench
The disorder of bar cell subsets, makes hypoimmunity mice CD4+/CD8+ ratio improve to close to normal
Level, promotes that B cell produces antibody, inducing interferon secretion etc., thus reaches to improve mouse immune merit
The effect of energy.
Modern medicine study shows, old and feeble essence is the decline of stem cell, the decline of immunity, tissue
The degeneration of organ dysfunction, the decline of defying age gene;Therefore, scientist thinks the immunity of human body to be improved
Power, the most basic way is the aging course of delaying human body.It is alive for evermore to pursue, and delays life, is people
Class dream for thousands of years, the problem about Human Longevity is studied the most long-term and unremittingly by human sciences family.This
Testing and confirm from a side, the present invention can significantly improve immunity level, and then can the most effectively support
Defying age.
Specific embodiment: Lin, man, 36 years old, in December, 2012 first visit.Readme is company management's layer,
Pressure is big, and working strength is big.It is homely food that overtime work is stayed up late, and dinner party is many, and tobacco and wine are not avoided.Sensation recently
Often flu.Every day works at office building, and pressure is big, often the sensation unable dizziness of asthenia asthenia, eyes
Dry and astringent, fuzzy viewing.The most often flu, and insomnia and dreamful sleep, the driest, readme hypoimmunity.Husband
Wife's inharmonious sexual life, has impotence and premature ejaculation phenomenon to occur.Removing examination in hospital blood item, B ultrasonic has no organic
Pathological changes.Because of the most ill, increase the weight of the consumption of body, variable interval of having a meal, tobacco and wine are immoderate, and dinner party is many,
Cause lethargy, fatigue and weak, love life is discord, nocturia, appetite reduce, sleep barrier
Hinder.Sick, having an injection to take medicine has become homely food.The most sick will being lot more time to is recovered, and
And because taking medicine throughout the year, Chinese medicine is produced resentment, it is proposed that replace taking Chinese medicine with oral liquid.
Fang Yong: Semen Cuscutae 25g, Semen Coicis 12g, Radix Angelicae Sinensis 13g, Rhizoma Polygonati 13g, Fructus Corni 12g, Poria 11g,
Radix Salviae Miltiorrhizae 13g, Radix Codonopsis 12g, Fructus Lycii 12g, Radix Polygoni Multiflori Preparata 13g, Radix Rehmanniae Preparata 14g, Rhizoma Atractylodis Macrocephalae 14g, Fructus Schisandrae Chinensis 12g,
Fructus Ligustri Lucidi 12g, Radix Polygalae 13g, Radix Ophiopogonis, 13g, Radix Trichosanthis 13g, Radix Paeoniae Rubra 13g, Rhizoma Curculiginis 14g, made oral
Liquid, three times a day, each 1 bottle.After taking 7 days, the conscious all diseases of patient are improved, and sleep disorder lowers, essence
The dispirited improvement of god, fatigue and weak improve, have rosy cheeks, no longer lassitude.Continue to take 1 month,
Sleeping, the mental status is the best, and working is full of energy, removes unnecessary dinner party, wine for giving off smoking from.Readme
Love life starts harmony.It is continuing with month all disease all to disappear, full of vitality.In using always.