CN105213999A - Radix Salviae Miltiorrhizae leaf health-care tea of a kind of antalgic and preparation method thereof - Google Patents

Abstract

A kind of health tea of Radix Salviae Miltiorrhizae leaf of antalgic, described Radix Salviae Miltiorrhizae leaf health-care tea comprises the raw material of following weight portion: 10 ~ 50 parts, Radix Salviae Miltiorrhizae leaf, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Fructus Evodiae 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, Rhizoma Corydalis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Radix Urenae Lobatae 10 ~ 20 parts, Herba Duchesneae Indicae 10 ~ 20 parts, Radix Rhodomyrti 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Folium Malloti Apeltae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Pollen Typhae 10 ~ 20 parts, Herba Sedi 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts.This health tea can not bring side effect to human body, can not cause the burden of kidney and the intestines and stomach.Rapid-action to the most obvious effect of dysmenorrhea patient.

Description

Radix Salviae Miltiorrhizae leaf health-care tea of a kind of antalgic and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly a kind of Radix Salviae Miltiorrhizae leaf health-care tea and preparation method thereof of antalgic.

Background technology

Dysmenorrhea is one of modal gynecological symptom, before and after referring to pass through or menstrual phase there is lower abdominal pain, falling inflation, with the soreness of waist or other are uncomfortable, serious symptom affects quality of life person.Dysmenorrhea is divided into primary dysmenorrhea and Secondary cases two class, and primary dysmenorrhea refers to the dysmenorrhea of genitals without organic disease, accounts for dysmenorrhea more than 90%; Secondary dysmenorrhea refers to the dysmenorrhea caused by pelvic cavity organic disease.

The generation of primary dysmenorrhea is mainly increased relevant with endometrium Prostaglandin during menstruation.PGF2 alpha content causes the main cause of dysmenorrhea when raising.PGF2 alpha content height can cause uterine smooth muscle to cross strong contraction, vasospasm, causes uterus ischemia, anoxia state and occur dysmenorrhea.The increase of the material such as vasopressin, endogenous oxytocin and beta-endorphin also can cause dysmenorrhea in addition.Spirit, neural factors also can cause dysmenorrhea.

Primary dysmenorrhea is common in adolescence, falls ill after menophania of being everlasting in 1 ~ 2 year.Pain is many to start after menstrual onset, appears at premenstrual 12 hours the earliest, and to pass through, pain on the 1st is the most violent, continues to alleviate after 2 ~ 3 days.Pain often in spastic, be positioned on hypogastric region pubis, can be radiated to lumbosacral region and femoribus internus.With nausea,vomiting,diarrhea, dizziness, the symptom such as weak, time serious, complexion is turned white, is in a cold sweat.Gynecologial examination discovery without exception.

According to menstrual phase lower abdomen pendant pain, the no positive sign of gynecologial examination, clinical namely diagnosable.The secondary dysmenorrhea that need cause with endometriosis, adenomyosis of uterus, pelvic inflammatory disease is differentiated mutually.

Dysmenorrhea is common symptom in women, and after pre-marital dysmenorrhea is particularly given birth to after growing up after marriage, dysmenorrhea can disappear naturally, can treat.Except individual cases.But the pain time of dysmenorrhea reaches 3 days persons should be treated.The treatment of primary dysmenorrhea, mainly symptomatic treatment, with pain relieving, calmness is main, all adopts Comprehensive Treatment to comprise spirit in recent years and dredges, Chinese medicine, Western medicine and acupuncture and moxibustion therapy.

Radix Salviae Miltiorrhizae (SalviamiltiorrhizaBge.) is Labiatae (Labiatae) Salvia (Salvia) plant, is used as medicine with root.Current Radix Salviae Miltiorrhizae underground part and preparation thereof are widely used in clinical, but a large amount of aerial partss is given it up.There are some researches show, Radix Salviae Miltiorrhizae overground part contains the water soluble ingredient similar to root, and aerial parts is about the heavy twice of root, therefore, very necessary to the exploitation of Radix Salviae Miltiorrhizae overground part, and salvia root leaf tea is exactly a kind of mode of exploitation Radix Salviae Miltiorrhizae leaf.The present invention carries out dynamic analysis to the effective ingredient in Radix Salviae Miltiorrhizae leaf, and the Radix Salviae Miltiorrhizae leaf of to gather the highest period with chemical composition content for raw material, and controls the technological parameter of the salvia root leaf tea course of processing, to develop the high-quality salvia root leaf tea containing higher effective ingredient.Carry out preliminary analysis to the drinking method of salvia root leaf tea and antioxygenic property thereof, the popularization for salvia root leaf tea provides technical support and theory support simultaneously.Result of study is as follows: (1) Radix Salviae Miltiorrhizae leaf moisture after August is substantially constant, and chlorophyll, carotenoid, soluble sugar, total phenols, flavonoid, vitamin C, salvianolic acid B and rosmarinic acid are in content peak period in JIUYUE substantially to mid-October.Consider that Radix Salviae Miltiorrhizae seals ridge in JIUYUE, picking leaves does not only affect Radix Salviae Miltiorrhizae root growth during this period, is conducive to ventilation and penetrating light on the contrary; And after mid-October, Radix Salviae Miltiorrhizae leaf starts aging, various chemical composition content declines.Therefore, the suitable collection period of Radix Salviae Miltiorrhizae leaf is that JIUYUE is to mid-October.(2) wither flavonoid, total phenols and the free aminoacid content adding Radix Salviae Miltiorrhizae leaf, but reduce the content of soluble sugar simultaneously, therefore to note the length of withering time, thus reach the active component both improving salvia root leaf tea, greatly can not affect again the organoleptic quality of salvia root leaf tea.This research finds that the most applicable withering time of Radix Salviae Miltiorrhizae leaf is about 6h.(3) by analyzing salvia root leaf tea fixing method, fresh leaf processing method to the impact of salvia root leaf tea chemical composition and organoleptic quality, show that the fresh leaf of Radix Salviae Miltiorrhizae does not cut that to carry out steam beating effect best.(4) knead the broken cell rate that can increase salvia root leaf tea, thus its water extraction content is increased, be conducive to the brewing property improving salvia root leaf tea.(5) by analyzing the impact on salvia root leaf tea chemical composition and organoleptic quality of different dry drying method, show that the salvia root leaf tea quality of oven dry is better.(6) test is brewed to salvia root leaf tea, show that preferably brewing conditions is: brew water temperature 100 DEG C, brew tea-water proportion 1g: 50mL, brewing time 3-5min.Wherein brew water temperature to have the greatest impact to the water extraction of salvia root leaf tea and organoleptic quality.(7) water extract of salvia root leaf tea, Radix Salviae Miltiorrhizae leaf and red sage root tea and ethanol extraction in hydroxyl radical free radical clearance rate, remove in DPPH free radical, reducing power and inhibition of peroxidation etc. and all have certain effect, and the oxidation resistance of salvia root leaf tea is higher than Radix Salviae Miltiorrhizae leaf and red sage root tea, show through being processed with the raising helping salvia root leaf tea oxidation resistance.

Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.How the efficacy exertion of the Radix Paeoniae Alba not being injured human body again to maximum, and obviously improve mouthfeel, people can be accepted, is our problem in the urgent need to address.Human body is " flesh and blood ".Only have hemapodium, just seem that skin is ruddy, face is glossy, and only have meat real, just can have muscular, build is vigorous and graceful.For women, pursue face gorgeous, stature is gentle and graceful, should focus on and nourish blood.Woman's Yangxuemeiyan achieves gentle and graceful stature has due to female pathology the feature that " cycle " hematozemia is many, sets up their relationship with blood.Chinese medicine is pointed out for a long time: " women is to nourish blood as this." if women is bad to nourish blood, just easily occur that shallow complexion, lip and nail are pale, limb is puckery, dried and withered hairs, dizziness, dim eyesight, the Blood deficiency such as weak, out of breath, i.e. anemia.The senilism symptom such as wrinkle, poliosis, debentition also occur severe anemia person very easily too early, walk haltingly.The Radix Paeoniae Alba is cold, bitter in the mouth acid, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receive the effect such as antiperspirant, can treat the diseases such as fever due to yin deficiency, menoxenia, dysentery stomachache, can also invigorating qi and benefiting blood, whitening and speckle dispelling.Chinese medicine health care product has advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.

Summary of the invention

Technical problem to be solved by this invention is, Western medicine is at present with pain relieving, and calmness is main, and these Therapeutic Method toxic and side effects are larger; And health protection with Chinese medicine product, often can be difficult to Symptomatic medicine, and specific aim is not strong, therapeutic effect is general; Therefore find safety, effective, full relief dysmenorrhes problem, be one of pendulum important topic in face of vast medical research worker.

For solving these technical barriers, the invention provides a kind of health tea of Radix Salviae Miltiorrhizae leaf of antalgic, described in it, Radix Salviae Miltiorrhizae leaf health-care tea comprises the raw material of following weight portion: 10 ~ 50 parts, Radix Salviae Miltiorrhizae leaf, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Fructus Evodiae 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, Rhizoma Corydalis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Radix Urenae Lobatae 10 ~ 20 parts, Herba Duchesneae Indicae 10 ~ 20 parts, Radix Rhodomyrti 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Folium Malloti Apeltae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Pollen Typhae 10 ~ 20 parts, Herba Sedi 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts.

The health tea of the Radix Salviae Miltiorrhizae leaf of described antalgic, described in it, the parts by weight of the various raw material of the health tea of Radix Salviae Miltiorrhizae leaf can be: 10 ~ 30 parts, Radix Salviae Miltiorrhizae leaf, the Radix Paeoniae Alba 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, Fructus Evodiae 10 ~ 15 parts, Oletum Trogopterori 10 ~ 15 parts, 10 ~ 15 parts, Rhizoma Curcumae Longae, Rhizoma Corydalis 10 ~ 15 parts, Caulis Spatholobi 10 ~ 20 parts, Radix Urenae Lobatae 10 ~ 20 parts, Herba Duchesneae Indicae 10 ~ 20 parts, Radix Rhodomyrti 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Folium Malloti Apeltae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Pollen Typhae 10 ~ 20 parts, Herba Sedi 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts.

The health tea of the Radix Salviae Miltiorrhizae leaf of described antalgic, described in it, the parts by weight of the various raw material of the health tea of Radix Salviae Miltiorrhizae leaf can also be: 10 ~ 50 parts, Radix Salviae Miltiorrhizae leaf, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Fructus Evodiae 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, Rhizoma Corydalis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Radix Urenae Lobatae 10 ~ 20 parts, Herba Duchesneae Indicae 10 ~ 20 parts, Radix Rhodomyrti 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Folium Malloti Apeltae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Pollen Typhae 10 ~ 20 parts, Herba Sedi 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Radix Salviae Miltiorrhizae leaf health-care tea of antalgic, and described in it, the preparation process of health tea comprises:

A.9 Radix Salviae Miltiorrhizae leaf is plucked the moon to mid-October, the preparation of Radix Salviae Miltiorrhizae leaf;

B. the Radix Salviae Miltiorrhizae leaf fried is kneaded, Titian;

C. other raw material pulverizing described, immersion ethanol are added extraction heat;

D. again by surplus stock extract medical filtration, be condensed into granule, powder or unguentum;

E. concentrated granule, powder or unguentum are mixed with the Radix Salviae Miltiorrhizae leaf prepared, sterilizing is prepared into health care medicinal tea.

In described step a, can JIUYUE to the fresh and tender Radix Salviae Miltiorrhizae leaf of picked by hand mid-October, dry in the sun, parches; Radix Salviae Miltiorrhizae leaf good for dry in the sun is put into the pot that completes and goes green grass or young crops, complete 20-30 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when Radix Salviae Miltiorrhizae leaf color starts jaundice, starts little fire and to stir-fry molding in 20-30 minute.

In described step b, the Radix Salviae Miltiorrhizae leaf fried can be kneaded, then put into fragrance extracting machine Titian 20-30 minute, naturally dry after taking out.

In described step c, other raw materials can be got and clean and dry, in 70 DEG C of baking ovens, dry 8-12h, take out and be placed in cooling in drying baker, pulverized 80-100 mesh sieve with pulverizer; To be soaked the particulate matter that sieves in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled half an hour third time, filter, heating is concentrated into paste, stand for standby use.

In described steps d, paste extract can be placed in 70-90% ethanol and soak 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, 50-60% ethanol is added in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, be condensed into pasty state filtrate, then insert in economic benefits and social benefits vacuum concentrator, the unguentum after concentrated adds Mel mediation and makes granule; Or convection drying makes powder.

In described step e, the Radix Salviae Miltiorrhizae leaf made can be mixed with other raw materials of refinement, pack after ultraviolet ray sterilization bactericidal.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Radix Salviae Miltiorrhizae leaf health-care tea of antalgic, the preparation process of all the other raw materials can also be: get other raw materials and clean roguing, steep in the ethanol of 5-10 times amount, medicated powder is equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill; Filtrate above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds Mel mediation and makes granule; Or convection drying makes powder.

These health product are relieving dysmenorrheas, can premenstrually take.The present invention need take in the previous week in menstrual period.Quickly alleviating pain is played to dysmenorrhea, and eliminates water retention and the various premenstrual syndrome shape such as stomachache, headache, mammary swelling, lower limbs edema that causes of emotion changes in menstrual period.Rationally take, side effect can not be brought to human body, the burden of kidney and the intestines and stomach can not be caused.Rapid-action to the most obvious effect of dysmenorrhea patient.

Detailed description of the invention

Dysmenorrhea is one of modal gynecological symptom, before and after referring to pass through or menstrual phase there is lower abdominal pain, falling inflation, with the soreness of waist or other are uncomfortable, serious symptom affects quality of life person.Dysmenorrhea is divided into primary dysmenorrhea and Secondary cases two class, and primary dysmenorrhea refers to the dysmenorrhea of genitals without organic disease, accounts for dysmenorrhea more than 90%; Secondary dysmenorrhea refers to the dysmenorrhea caused by pelvic cavity organic disease.The traditional Chinese medical science is often said " pain is then obstructed ".Warming the meridian blood stasis dispelling of the present invention, regulating QI to relieve pain, for QI stagnated by cold blood stasis, dysmenorrhes, few abdomen cold type of pain, menoxenia, light and dull menses.

Radix Salviae Miltiorrhizae (SalviamiltiorrhizaBge.) is Labiatae (Labiatae) Salvia (Salvia) plant, is used as medicine with root.Current Radix Salviae Miltiorrhizae underground part and preparation thereof are widely used in clinical, but a large amount of aerial partss is given it up.There are some researches show, Radix Salviae Miltiorrhizae overground part contains the water soluble ingredient similar to root, and aerial parts is about the heavy twice of root, therefore, very necessary to the exploitation of Radix Salviae Miltiorrhizae overground part, and salvia root leaf tea is exactly a kind of mode of exploitation Radix Salviae Miltiorrhizae leaf.The present invention carries out dynamic analysis to the effective ingredient in Radix Salviae Miltiorrhizae leaf, and the Radix Salviae Miltiorrhizae leaf of to gather the highest period with chemical composition content for raw material, and controls the technological parameter of the salvia root leaf tea course of processing, to develop the high-quality salvia root leaf tea containing higher effective ingredient.Carry out preliminary analysis to the drinking method of salvia root leaf tea and antioxygenic property thereof, the popularization for salvia root leaf tea provides technical support and theory support simultaneously.Result of study is as follows: (1) Radix Salviae Miltiorrhizae leaf moisture after August is substantially constant, and chlorophyll, carotenoid, soluble sugar, total phenols, flavonoid, vitamin C, salvianolic acid B and rosmarinic acid are in content peak period in JIUYUE substantially to mid-October.Consider that Radix Salviae Miltiorrhizae seals ridge in JIUYUE, picking leaves does not only affect Radix Salviae Miltiorrhizae root growth during this period, is conducive to ventilation and penetrating light on the contrary; And after mid-October, Radix Salviae Miltiorrhizae leaf starts aging, various chemical composition content declines.Therefore, the suitable collection period of Radix Salviae Miltiorrhizae leaf is that JIUYUE is to mid-October.(2) wither flavonoid, total phenols and the free aminoacid content adding Radix Salviae Miltiorrhizae leaf, but reduce the content of soluble sugar simultaneously, therefore to note the length of withering time, thus reach the active component both improving salvia root leaf tea, greatly can not affect again the organoleptic quality of salvia root leaf tea.This research finds that the most applicable withering time of Radix Salviae Miltiorrhizae leaf is about 6h.(3) by analyzing salvia root leaf tea fixing method, fresh leaf processing method to the impact of salvia root leaf tea chemical composition and organoleptic quality, show that the fresh leaf of Radix Salviae Miltiorrhizae does not cut that to carry out steam beating effect best.(4) knead the broken cell rate that can increase salvia root leaf tea, thus its water extraction content is increased, be conducive to the brewing property improving salvia root leaf tea.(5) by analyzing the impact on salvia root leaf tea chemical composition and organoleptic quality of different dry drying method, show that the salvia root leaf tea quality of oven dry is better.(6) test is brewed to salvia root leaf tea, show that preferably brewing conditions is: brew water temperature 100 DEG C, brew tea-water proportion 1g: 50mL, brewing time 3-5min.Wherein brew water temperature to have the greatest impact to the water extraction of salvia root leaf tea and organoleptic quality.(7) water extract of salvia root leaf tea, Radix Salviae Miltiorrhizae leaf and red sage root tea and ethanol extraction in hydroxyl radical free radical clearance rate, remove in DPPH free radical, reducing power and inhibition of peroxidation etc. and all have certain effect, and the oxidation resistance of salvia root leaf tea is higher than Radix Salviae Miltiorrhizae leaf and red sage root tea, show through being processed with the raising helping salvia root leaf tea oxidation resistance.

The Radix Paeoniae Alba is applicable to people's breast abdomen pain over the hypochondriac region of the blood deficiency deficiency of YIN, pain in the hepatic region, and cholecystitis gallstones pain person should eat; Dysentery is suffered from abdominal pain, and women's menalgia person should eat; Spontaneous perspiration easy antiperspirant night sweat person should eat; Sural spasm, spasm of the limbs pain, uneasy lower limb syndrome patients should eat; Coordinate with alleviating various breast abdomen and limbs pain with Radix Glycyrrhizae.But the Radix Paeoniae Alba is cold in nature, the deficient cold type stomachache person of having loose bowels diet; Diet during children's suffers from measles; Take Chinese medicine Rhizoma et radix veratri (Radix Rhizoma Veratri) person diet.

Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower." herbal classic ": Your Majesty's gas cough with dyspnea, stagnation of QI sore throat tells suction, sharp joint, invigorating the spleen and replenishing QI." not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, only saliva, cough ， Bi Weng: can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared.

Flos Albiziae filigree pink, pod is inclined, is urban path tree, views and admires tree.The yellow taupe of heartwood, sapwood yellow-white, durable, be used for furniture processed; Tender leaf is edible, and Lao Ye can wash clothes; Bark hyoscine, has the effect of anthelmintic.It also has calming effects, mainly controls the effects such as pent-up is uncomfortable in chest, insomnia forgetfulness, nourishing YIN and invigorating YANG, ophthalmic, neurasthenia.Flos Albiziae contains Herba Albiziae glycoside, tannin, resolving stagnation for tranquilization, nourishing YIN and invigorating YANG, appetizing of regulating the flow of vital energy, activating collaterals to relieve pain, for, melancholy insomnia.Control pent-up uncomfortable in chest, insomnia, forgetful, acute conjunctivitis, can settling five organs, and will, improving healthy complexion, have keep fit preferably, calm, the effect of calming the nerves, improve looks, be treat neurasthenic good merchantable brand.Have clearing away summer-heat, face-beautifying and spot-removing such as to relieve the effect of alcohol at the effect.The traditional Chinese medical science is thought: Flos Albiziae nature and flavor are sweet, flat, Shu Yu, regulate the flow of vital energy, calm the nerves, active, nourish blood, YIN nourishing kidney, clear away heart-fire improving eyesight.Shennong's Herbal: " Herba Albiziae, settling five organs, and will make us happy carefree." " book on Chinese herbal medicine is just read ": " can nourish blood, lively atmosphere, to promote blood circulation.

Oletum Trogopterori (FaecesTrogopterori) has another name called medicine basis, number worm excrement of trembling with fear, Oletum Trogopterori are divided into Oletum Trogopterori rice, Oletum Trogopterori block (XUELINGZHI, sugared Oletum Trogopterori) two kinds.The dry feces of Oletum Trogopterori rice and trogopterus xanthipes Milne-Edwards, Oletum Trogopterori block is that the mixture of its feces and urine presss from both sides to condense with the drying of a small amount of sandstone and forms.Oletum Trogopterori is the dry feces of trogopterus xanthipes Milne-Edwards, can be used for blood-stasis internal-depression, escape of blood from meridian hemorrhage, if woman uterine bleeding is through many, the purple polylith of color, stabbing pain of the lower abdomen.Both can single fry ground into powder, heat wine takes, again can with other drug with the use of.Oletum Trogopterori is blood-activating and stasis-removing

Rhizoma Corydalis, Chinese medicine name.For the dry tuber for papaveraceae plant corydalis.Have and invigorate blood circulation, circulation of qi promoting, effect of pain relieving.For the breast side of body, epigastric pain, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.Compendium of Material Medica: promoting the circulation of QI of invigorating blood circulation, pain relieving, diuresis." opening treasured ": removing blood stasis, married woman's menoxenia, lumps in abdomen, metrorrhagia drench dew, puerperal all disorders of blood, blood transport, sudden and violent blood rushes to, because of damage hematochezia.Boil wine or wine mill clothes.

Radix Urenae Lobatae is Malvaceae Herba urenae procumbentis platymiscium Urena lobata Linn UrenalobataL., with root and all herbal medicine.Autumn excavates, and clean chopping is dried.Meridian distribution of property and flavor is sweet, light, cool.Function cures mainly] expelling wind and activating blood circulation, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Root: for rheumatic arthritis, flu, malaria, enteritis, dysentery, infantile dyspepsia, leucorrhea.Herb: traumatic injury is controlled in external, fracture, venom, mastitis." figure will planted by Guangxi medicine ": herb, controls poisonous snake wound, acute infantile convulsion, tetanus, asthma.Root, controls gonorrhea, two single throat moth, outer sensible heat, dysentery." Luchuan book on Chinese herbal medicine ": removing mass, loose poison.Control traumatic injury, carbuncle sore." Nanning City's medicine will ": the merit having eliminating inflammation and expelling toxin, hemostasis and pain-relieving, evacuation of pus granulation promoting.Control red Hakuri.

Herba Duchesneae Indicae, has another name called YEXIAHONG, Radix seu Folium Alchorneae trewioidis, Herba Emiliae, false cabbage mustard.Begin to be loaded in " Zhiwu Mingshi Tukao ", original name purple back of the body grass.For the herb of feverfew Herba Duchesneae Indicae Emiliasor.chifolia (L.) DC..。Its bitter in the mouth, cool in nature.There is heat-clearing and toxic substances removing, effect of dissipating blood stasis for subsidence of swelling.For upper respiratory tract infection, oral ulcer, pneumonia, mastitis, enteritis, bacillary dysentery, urinary tract infection, furuncle carbuncle, eczema, traumatic injury.

Radix Rhodomyrti is myrtaceous root, is mainly distributed in the ground such as Guangdong, Guangxi, Fujian, Yunnan.Containing the chemical analysis such as phenols, tannin, sweet in the mouth, puckery, property are put down.Inhibitory action is had to staphylococcus aureus.This product can external oral administration again, have nourish blood, dispelling wind and removing obstruction in the collateral, convergence function.

Folium Malloti Apeltae, formal name used at school Mallotuspaniculatus.Nontoxic.Function cures mainly heat clearing away, dampness removing, pain relieving, removing toxic substances, hemostasis.Control stranguria with turbid discharge, stomachache, aphtha, hemorrhoid, ulcer, traumatic injury, venom, traumatic hemorrhage.Control traumatic hemorrhage, ulcer: Folium Malloti Apeltae dries, wipe into velveteen sample and harvest and store, get and stick in right amount time hemorrhage, additional binder is fixed.(" south of the Five Ridges herbal ")

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Fructus Mori nourishing YIN and benefiting blood medicine; Promote the production of body fluid medicine; Aperitive.To enrich blood YIN nourishing, promote the production of body fluid and moisturize.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.Tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Both can food, can be used as medicine again, the traditional Chinese medical science thinks the acid of Fructus Mori sweet in the mouth, and cold nature, enters the heart, liver, kidney channel, is strengthening by means of tonics, the good fruit of the heart nourishing and intellengence improving.There is YIN nourishing of enriching blood, promoting the production of body fluid to quench thirst, the effects such as intestine moistening is dry, cure mainly deficiency of YIN-blood and having a dizzy spell of causing, tinnitus cardiopalmus, irritated insomnia, soreness of the waist and knees, early whitening of beard and hair, xerostomia of quenching one's thirst, the diseases such as constipation with dry stool.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.External is gynecological's good medicine of activating blood circulation to dissipate blood stasis.

Spica Prunellae (Classification system: Prunellavulgaris), also known as ferrum color grass.Bitter, acrid, cold.Enter liver, gallbladder meridian.To relieve inflammation or internal heat improving eyesight: control conjunctival congestion and swelling pain, headache.Clearing away liver-fire, blood pressure lowering: control hypertension, hyperlipidemia, high blood viscosity and hyperglycemia.Mass dissipating and swelling eliminating: control scrofula, goiter, acute mastitis swell and ache.Function cures mainly liver heat removing, eliminating stagnation, diuresis; Control the diseases such as pestilence, acute mastitis, ophthalmalgia, jaundice, gonorrhea, hypertension; Leaf can for tea.Control lymphoid tuberculosis, thyromegaly, scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia are shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.

Fructus Gardeniae is Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, is usually used in the diseases such as treatment icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.Cure mainly calentura vexed; Liver-fire conjunctival congestion; Headache; Jaundice due to damp-heat; Stranguria; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.This product has very large curative effect to conjunctival congestion and swelling pain.These product rush down clearly three burnt pathogenic heats, can treating the liver gallbladder burning hot on the conjunctival congestion and swelling pain of attacking, often join Radix Et Rhizoma Rhei use, as Fructus Gardeniae soup " Shengji Zonglu ".

Fructus Evodiae formal name used at school Tetradiumruticarpum, original name Euodiaruticarpa, another name Fructus Evodiae, tea is peppery, paint spicy, smelly spicy tree, Zuo Lichun deep and remote son, rice spicy etc.Namely tender fruit is Chinese medicine Fructus Evodiae after brewed airing, is called for short Fructus Evodiae, is bitter stomachic and analgesics, makes lumbricide again.Its bitter in the mouth hot in nature is pungent, has the merit of dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, is used for the treatment of that liver insufficiency of stomach is trembled with fear, the disease such as headache or gastralgia caused by cloudy turbid superinverse.Warming middle-JIAO, pain relieving, regulates the flow of vital energy, dampness, [4], headache due to JUE YIN disorder, and the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, abdominal pain during menstruation, Diarrhoea, vascular hypertension, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo." herbal classic ": main warming the middle warmer and descending qi, pain relieving, cough with dyspnea cold and heat, dehumidifying arthralgia due to stagnation of blood, by ailment said due to cold or exposure, loosing the interspaces of skin and muscles." not Lu ": main expectorant is cold, angor in abdomen, and Zhu Lengshi does not disappear, attacked by pestiferous factors, cardiac and abdominal pain, inverse gas, sharp the five internal organs." property of medicine opinion ": main trusted subordinate's disease, accumulation of pathogenic cold, stagnation of QI under the heart, chronic infectious disease is pained; Control cramp caused by acute vomiting and diarrhea, cold in the stomach gas, vomiting and diarrhoea stomachache can not win the person of bearing; Treat insensitive impediment all over, cold drinks and snachs does not disappear, and sharp large intestine gathers around gas.

Pollen Typhae, Chinese medicine name.For the dry pollen of Typhaceae plant Typha angustifolia Herba Typhae TyphaangustifoliaL., typha orientalis TyphaorientalisPresl or congener.Gather summer the yellow staminate inflorescence on Spica Typhae top, dry rear rolloff, sieve gets pollen.After clip male flower, dry, become the pollen with male flower, be POLLEN TYPHAE CUM STAMEN.Hemostasis, blood stasis dispelling, treating stranguria.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea stimulates the menstrual flow, breast ventral spine pain, tumbling and swelling, blood strangury and dry pain.Compendium of Material Medica: removing heat from blood and promoting blood circulation, the only all pains of trusted subordinate." herbal classic ": trusted subordinate's frigiopyrexia of bladder, diuresis, hemostasis, repercussive blood.Clothes of a specified duration are made light of one's life by commiting suicide physical strength profiting, and prolong life angle.

Folium Perillae: logical heart channel, strengthening the spleen stomach." detailed outline ": promoting the circulation of QI to alleviate the stagnation in middle-JIAO, expectorant profit lung, and blood, warming middle-JIAO, pain relieving, Dingchuan, antiabortive." book on Chinese herbal medicine meets former ": the heresy of the blood vessels that can fall apart." book on Chinese herbal medicine converge with speech " " detailed outline " Folium Perillae, modern times key medicine also.Its acrid in the mouth, enters edema caused by disorder of QI, and its color is purple, enters blood system.Therefore same Pericarpium Citri tangerinae, Fructus Amomi, then circulation of qi promoting is antiabortive; Same Herba Pogostemonis, the Radix Linderae, then warming middle-JIAO to relieve pain; Same Rhizoma Cyperi, Herba Ephedrae, then diaphoresis expelling pathogenic factors from muscles; Same Rhizoma Chuanxiong, Radix Angelicae Sinensis, then with blood, loose blood; Same Fructus Chaenomelis, Cortex Magnoliae Officinalis, then wet dissipation expelling summer-heat, control cholera foot gas; Same Radix Platycodonis, Fructus Aurantii, the then wide intestinal of sharp diaphragm; Same Semen Armeniacae Amarum, Semen Raphani, then sputum eliminating to stop asthma." book on Chinese herbal medicine converge with speech " Folium Perillae, cold expelling gas, lung heat clearing gas, alleviating distention in middle-JIAO gas, antiabortive gas, lower stagnation of QI, flower mental disorder, be control gas refreshing medicine also.One thing has three with here: as cold typhoid fever, headache osteodynia, fever with aversion to cold, and podomere is unfavorable, or beriberi hernia, evil strongly fragrant table person, and Folium Perillae can fall apart heresy and inducing sweat; Stagnation of QI knot and fullness in the epigastrium and abdomen painful abdominal mass plug, chest and diaphragm is unfavorable, or nausea is forced, abdomen side of body distending pain person, and Caulis Perillae can pleasant and alleviating distention in middle-JIAO; If or dyspnea due to adverse flow of lung-QI is inverse, Fructus Perillae can Dingchuan and the therapeutic method to keep the adverse QI flowing downwards.Phlegm-fire is run quickly and is compeled, and Fructus Perillae can pathogenic fire reducing and clearing away phlegm, three's difference used, method when in detail it

Herba Sedi (Classification system: SedumsarmentosumBunge), another name: Canis familiaris L. tooth half, Canis familiaris L. tooth lobe, Mus tooth half, Herba Sedi Sarmentosi, Herba Sedi Multicaulis, Herba Portulacae Grandiflorae, Herba Sedi generally grow at hillside rock stone gap, limit, gully, moistening place, river bank, very easily cultivate, not tight to environmental requirement, all can plant behind the house before family, also can be potted plant, usual employing division propagation, Herba Sedi is the conventional medicinal herbs that folklore is extremely wide simply, all herbal medicine, has effect of heat-clearing and toxic substances removing, swelling diuretic, evacuation of pus granulation promoting etc.Clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main jaundice due to damp-heat; Gonorrhea; Dysentery; Lung abscess; Intestinal carbuncle; Furuncle toxic swelling; Snake bite and insect sting; Burn due to hot liquid or fire; Laryngopharynx swelling and pain; Oral ulcer and eczema; Herpes zoster.

Rhizoma Curcumae Longae Rhizoma Curcumae Longae energy circulation of qi promoting removing blood stasis with potent drugs, inducing menstruation to relieve menalgia.Cure mainly chest and abdomen swelling and pain, shoulder arm arthralgia pain, unbearably pained, puerperal blood pain, skin ulcer tinea onset, menoxenia, amenorrhea, traumatic injury.Yellow food colour can be extracted again; Contained curcumin can perform an analysis chemical reagent.Hyoscine, energy circulation of qi promoting removing blood stasis with potent drugs, inducing menstruation to relieve menalgia.Cure mainly chest and abdomen swelling and pain, shoulder arm arthralgia pain, menoxenia, amenorrhea, traumatic injury.Yellow food colour can be extracted again; Contained curcumin can perform an analysis chemical reagent.Removing blood stasis, circulation of qi promoting, stimulates the menstrual flow, pain relieving.Control trusted subordinate's feeling of fullness distending pain, brachialgia, lump in the abdomen, women's blood stasis amenorrhea, puerperal, the stasis of blood stopped stomachache, injury from falling down, carbuncle.Breast for qi depression to blood stasis is suffered from abdominal pain, dysmenorrhea and limbs pain, often joins Rhizoma Corydalis, Rhizoma Cyperi.Tang Materia Medica: main trusted subordinate ties long-pending, and chronic infectious disease is disobedient, the therapeutic method to keep the adverse QI flowing downwards, removing blood stasis, except wind heat, subduing inflammation.Power is strong in Radix Curcumae." Japan hanako materia medica ": control lump in the abdomen clot, carbuncle, logical menstruation, controls to fall and flutters blood stasis, detumescence poison; Only storm wind pain cold air, lower food.

The specific embodiment of the invention

Specific embodiment 1:

First the 9-10 month pluck Radix Salviae Miltiorrhizae leaf, carry out parch, knead, Titian.

Again by all the other raw material Radix Paeoniae Albas, Radix Angelicae Sinensis, Cortex Cinnamomi, Fructus Gardeniae, Flos Albiziae, Fructus Evodiae, Oletum Trogopterori, Rhizoma Curcumae Longae, Rhizoma Corydalis, Caulis Spatholobi, Radix Urenae Lobatae, Herba Duchesneae Indicae, Radix Rhodomyrti, Fructus Mori, Folium Malloti Apeltae, Spica Prunellae, Pollen Typhae, Herba Sedi, Folium Perillae, pulverize, extraction, extracts and makes unguentum, granule or powder.

Two kinds of extract mixing, ultraviolet radiation for sterilizing and disinfecting packs.

Specific embodiment 2:

9-10 month picked by hand fresh and tender Radix Salviae Miltiorrhizae leaf 5000g, dry in the sun, parches; Radix Salviae Miltiorrhizae leaf good for dry in the sun is put into the pot that completes and goes green grass or young crops, complete 30-45 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when Radix Salviae Miltiorrhizae leaf color starts jaundice, starts little fire and to stir-fry molding in 20-30 minute.Put into fragrance extracting machine Titian 30-45 minute after being kneaded by the Radix Salviae Miltiorrhizae leaf fried, naturally dry after taking out.Get other raw material Radix Paeoniae Alba 1500g, Radix Angelicae Sinensis 1500g, Cortex Cinnamomi 1500g, Fructus Gardeniae 1500g, Flos Albiziae 1500g, Fructus Evodiae 1500g, Oletum Trogopterori 1500g, Rhizoma Curcumae Longae 1500g, Rhizoma Corydalis 1500g, Caulis Spatholobi 1500g, Radix Urenae Lobatae 1500g, Herba Duchesneae Indicae 1500g, Radix Rhodomyrti 1500g, Fructus Mori 1500g, Folium Malloti Apeltae 1500g, Spica Prunellae 1500g again, Pollen Typhae 1500g, Herba Sedi 1500g, Folium Perillae 1500g, clean and dry, in 70 DEG C of baking ovens, dry 8-12h, taking-up is placed in cooling in drying baker, pulverizes 80-100 mesh sieve with pulverizer; To be soaked the particulate matter that sieves in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled half an hour third time, filter, heating is concentrated into paste, stand for standby use.Paste extract is placed in 70-90% ethanol and soaks 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges lixiviating solution, is condensed into pasty state filtrate, insert in economic benefits and social benefits vacuum concentrator again, the unguentum after concentrated adds Mel mediation and makes granule; Or convection drying makes powder.Then add Mel to be in harmonious proportion, make granule, the Radix Salviae Miltiorrhizae leaf of mixing Titian, ultraviolet disinfection, packs and get final product.

Specific embodiment 3:

9-10 month picked by hand fresh and tender Radix Salviae Miltiorrhizae leaf 4000g, dry in the sun, parches; Radix Salviae Miltiorrhizae leaf good for dry in the sun is put into the pot that completes and goes green grass or young crops, complete 30-45 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when Radix Salviae Miltiorrhizae leaf color starts jaundice, starts little fire and to stir-fry molding in 20-30 minute.Put into fragrance extracting machine Titian 30-45 minute after being kneaded by the Radix Salviae Miltiorrhizae leaf fried, naturally dry after taking out.By all the other raw material Radix Paeoniae Alba 1100g described, Radix Angelicae Sinensis 1200g, Cortex Cinnamomi 1100g, Fructus Gardeniae 1200g, Flos Albiziae 1100g, Fructus Evodiae 1200g, Oletum Trogopterori 1100g, Rhizoma Curcumae Longae 1200g, Rhizoma Corydalis 1100g, Caulis Spatholobi 1200g, Radix Urenae Lobatae 1100g, Herba Duchesneae Indicae 1100g, Radix Rhodomyrti 1200g, Fructus Mori 1100g, Folium Malloti Apeltae 1100g, Spica Prunellae 1100g, Pollen Typhae 1200g, Herba Sedi 1100g, Folium Perillae 1200g, get other raw materials and clean roguing, steep in the ethanol of 5-10 times amount, medicated powder is equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, make abundant expansion, drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator, medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol, air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container, percolate is merged and leaves standstill, filtrate above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, unguentum after concentrated adds Mel mediation and makes granule, or convection drying makes powder.The Radix Salviae Miltiorrhizae leaf of mixing Titian, ultraviolet disinfection, packs and get final product.

Pharmacological toxicity is tested

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: Mouse oral gavage oral liquid of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage oral liquid of the present invention is 488.8g crude drug/kg/d (LD50 > 488.8g crude drug/kg).Oral liquid clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach oral liquid of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the oral liquid of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: oral liquid of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.

This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of oral liquid clinical practice of the present invention higher.

3, SD rat is selected, give the oral liquid of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: oral liquid of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test oral liquid of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of oral liquid clinical practice of the present invention higher.

Pharmacological experiment illustrates:

1 test material

1.1 experimental animals: Wistar rat, female; KM mice, female; There is provided by Qingdao City's laboratory animal and animal experimental center, credit number: SCXK (Shandong) 20080010.

1.2 test drug

Test medicine: health tea of the present invention, the decoction agent that embodiment 2 is extract obtained.Positive control drug: YUEYUESHU TONGJIBAO KELI, commercially available

2 contents of the test

2.1 health teas of the present invention are on the impact of castrated rats simulation female primary dysmenorrhea

2.1.1 animal grouping, administration

Get 60 female rats to anaesthetize with pentobarbital sodium, abdominal part carries out abdominal part upward to be fixed, midaxillary line and apart from 2cm infall cropping outside spinal column from rat back most end rib, incision skin and dorsal muscles are about 1.5-2cm, ovary is extractd after the fallopian tube of ligation ovary lower end, postoperative by uterus angular convolution abdominal cavity, suture muscles and skin.Same method extracts opposite side ovary, and injection 3 days penicillins are in case infect continuously, within postoperative 5th day, starts vaginal smear and observes Rats During The Estrous Cycle, continuous 5 days, no longer occurs that the oestrous cycle (being all in diestrus) is for castration success with rat.Random packet is model group, positive drug group and by the large, medium and small dosage group of reagent, 10/ group, separately gets 10 female rats (not doing castration operation) as Normal group.Postoperative 9th day starts by the gastric infusion of dosage shown in table 1, wherein oral liquid with all worries set aside is equivalent to 5 times of people's clinical application amount, health product of the present invention decoct 10 times, 5 times, 2.5 times that the large, medium and small dosage of agent is equivalent to people's clinical application amount respectively, matched group and model group gavage equivalent ordinary water, 1 times/day, continuous 30 days.Each group of Rat Fast be can't help water 12h and is tested to next day.

2.1.2 index determining

2.1.2.1 wild movable observing is opened: 1h after the administration of each treated animal last, rat autonomic activities situation is observed with Open-field test method, high 40cm is placed in respectively by each treated animal, length and width are 80cm, and perisporium is black, and bottom surface black line is divided into 25 pieces of area equation, using animal travels bottom surface square number as horizontal anomalous movement score, using upright number of times as Vertical movements score, every rat only carries out 1 time and measures, each 3min recording level, Vertical movements score.

2.1.2.2 hormone serum level and hypothalamus detect neurotransmitter detection

Rat extracting blood separation of serum, detects E2, FSH, LH, β-EP content in serum to put method of exempting from, and detects GSH-PX, SOD, MDA activity and content; Put to death rat and take off thalamus rapidly, detect E, NA, DA, 5-HT content in neurotransmitter hypothalamus with efficient liquid phase-electrochemical detection method.The results are shown in Table 1.

Table 1 this product is on the impact (.x ± s) of climacteric syndrome rat model gonadal hormone

Group	Estrogen level (ng/L)
		Model control group	4.58±1.70**
Medicine A group	6.28±1.96**
		Medicine B group	7.59±2.48*

Compare with model control group, * P < 0.05, * * P < 0.01

Test two: anti-pain experiments

Medicine: this product decocts agent, by optimum prescription proportioning, is divided into A, B group by extraction and purification process difference.

Animal: Kunming mouse, body weight 18 ~ 22g mice 50, is divided into 5 groups at random.Often organize 10, each 5 of male and female, grouping situation is in table 2.Each treated animal ig administration, blank group ig normal saline, continuous 10 days, 1h after last administration, mice being put into water temperature was that the tank of 20 DEG C is swum.Until mice sinks under water, calculate swimming time.Experimental result is in table 2.

Table 2 is on the impact (.X ± s) of mice swimming time

Group	Dosage (gkg -1)	Number of animals (only)	Swimming time (min)
				Blank group	--	10	6.79±2.03
A group	3.5	10	8.43±3.55*
				B group	3.5	10	8.64±3.13*
A+B group	7.0	10	11.81±3.75**
				YUEYUESHU group	3.3	10	9.02±4.41*

Note: compare with blank group, * P < 0.01, * * P < 0.001.

Experimental result shows, and this product 3.5g/kg and 7.0g/kg two dosage are energy significant prolongation mice swimming time all, compares * P < 0.01, * * P < 0.001 with blank group.

Test three: on the impact of the mice pentobarbital sodium length of one's sleep

Medicine: this product decocts agent, by optimum prescription proportioning, is divided into A, B group by extraction and purification process difference.Body weight 20 ~ 22g mice 50, is divided into 5 groups at random, often organizes 10, male female each 5.Grouping situation is in table 3.Each treated animal ig administration, blank group ig normal saline, continuous 5 days.1h after last medicine, with the dosage of 35mg/kg, mice ig pentobarbital sodium take righting reflex loss as index, record mouse sleep time.Experimental result, in table 3.

Table 3 is on the impact (.X ± s) of the mice pentobarbital sodium length of one's sleep

Group	Dosage (gkg -1)	Number of animals (only)	The length of one's sleep (min)
				Blank group	--	10	27.12±12.21
A group	3.5	10	36.92±8.25*
				B group	3.5	10	38.20±7.68*
A+B group	7.0	10	41.12±5.58*
				YUEYUESHU group	3.3	10	32.21±8.49

Note: each group compares with blank group, * P < 0.05.

Experimental result shows, this product to a certain degree can extend mice pentobarbital sodium length of one's sleep.

Result of the test shows, this product can improve the estrogen level of hypogonadism animal, has the effect of resisting fatigue, can hypnotic, for this product clinical treatment climacteric syndrome has established pharmacological basis.

Result shows, castration model group rats compares serum estradiol (E2) content to be reduced with normal rats, follicle stimulating hormone (FSH), lutropin (LH) activity increases, and all has significant (respectively P < 0.05, P < 0.01, P < 0.01); Positive drug and more easypro large, medium and small dosage group rat E2 and Normal group comparing difference are without significant; Chinese medicine composition of the present invention big or middle dosage group rat FSH compares with matched group, active reduction, and difference has significant (respectively P < 0.01, P < 0.01); Positive drug and Chinese medicine composition of the present invention large, medium and small dosage group rat LH compare with Normal group, activity increases, no significant difference (respectively P < 0.001, P < 0.05, P < 0.01, P < 0.01).Positive drug and Chinese medicine composition of the present invention large, medium and small dosage group rat E2 compare with castration model group rats, and content increases, and no significant difference (equal P < 0.05); The present invention's large, medium and small dosage group rat FSH compares with model group rats, active reduction, and difference has significant (respectively P < 0.001, P < 0.001, P < 0.01); Chinese medicine composition of the present invention large, medium and small dosage group rat LH compares with model group rats, and active reduction, difference has significant (equal P < 0.01).Test shows, Chinese medicine composition of the present invention significantly can increase castration rat model E2 content, reduces FSH, LH active, has a better role to the imbalance of castration rat model hormonal system.

Dysmenorrhea is one of modal gynecological symptom, before and after referring to pass through or menstrual phase there is lower abdominal pain, falling inflation, with the soreness of waist or other are uncomfortable, serious symptom affects quality of life person.Dysmenorrhea is divided into primary dysmenorrhea and Secondary cases two class, and primary dysmenorrhea refers to the dysmenorrhea of genitals without organic disease, accounts for dysmenorrhea more than 90%; Secondary dysmenorrhea refers to the dysmenorrhea caused by pelvic cavity organic disease.The traditional Chinese medical science is often said " pain is then obstructed ".More than test shows, warming the meridian blood stasis dispelling of the present invention, regulating QI to relieve pain, for QI stagnated by cold blood stasis, and dysmenorrhes, few abdomen cold type of pain, menoxenia, light and dull menses.

Radix Salviae Miltiorrhizae (SalviamiltiorrhizaBge.) is Labiatae (Labiatae) Salvia (Salvia) plant, is used as medicine with root.Current Radix Salviae Miltiorrhizae underground part and preparation thereof are widely used in clinical, but a large amount of aerial partss is given it up.There are some researches show, Radix Salviae Miltiorrhizae overground part contains the water soluble ingredient similar to root, and aerial parts is about the heavy twice of root, therefore, very necessary to the exploitation of Radix Salviae Miltiorrhizae overground part, and salvia root leaf tea is exactly a kind of mode of exploitation Radix Salviae Miltiorrhizae leaf.The present invention carries out dynamic analysis to the effective ingredient in Radix Salviae Miltiorrhizae leaf, and the Radix Salviae Miltiorrhizae leaf of to gather the highest period with chemical composition content for raw material, and controls the technological parameter of the salvia root leaf tea course of processing, to develop the high-quality salvia root leaf tea containing higher effective ingredient.Carry out preliminary analysis to the drinking method of salvia root leaf tea and antioxygenic property thereof, the popularization for salvia root leaf tea provides technical support and theory support simultaneously.Result of study is as follows: (1) Radix Salviae Miltiorrhizae leaf moisture after August is substantially constant, and chlorophyll, carotenoid, soluble sugar, total phenols, flavonoid, vitamin C, salvianolic acid B and rosmarinic acid are in content peak period in JIUYUE substantially to mid-October.Consider that Radix Salviae Miltiorrhizae seals ridge in JIUYUE, picking leaves does not only affect Radix Salviae Miltiorrhizae root growth during this period, is conducive to ventilation and penetrating light on the contrary; And after mid-October, Radix Salviae Miltiorrhizae leaf starts aging, various chemical composition content declines.Therefore, the suitable collection period of Radix Salviae Miltiorrhizae leaf is that JIUYUE is to mid-October.(2) wither flavonoid, total phenols and the free aminoacid content adding Radix Salviae Miltiorrhizae leaf, but reduce the content of soluble sugar simultaneously, therefore to note the length of withering time, thus reach the active component both improving salvia root leaf tea, greatly can not affect again the organoleptic quality of salvia root leaf tea.This research finds that the most applicable withering time of Radix Salviae Miltiorrhizae leaf is about 6h.(3) by analyzing salvia root leaf tea fixing method, fresh leaf processing method to the impact of salvia root leaf tea chemical composition and organoleptic quality, show that the fresh leaf of Radix Salviae Miltiorrhizae does not cut that to carry out steam beating effect best.(4) knead the broken cell rate that can increase salvia root leaf tea, thus its water extraction content is increased, be conducive to the brewing property improving salvia root leaf tea.(5) by analyzing the impact on salvia root leaf tea chemical composition and organoleptic quality of different dry drying method, show that the salvia root leaf tea quality of oven dry is better.(6) test is brewed to salvia root leaf tea, show that preferably brewing conditions is: brew water temperature 100 DEG C, brew tea-water proportion 1g: 50mL, brewing time 3-5min.Wherein brew water temperature to have the greatest impact to the water extraction of salvia root leaf tea and organoleptic quality.(7) water extract of salvia root leaf tea, Radix Salviae Miltiorrhizae leaf and red sage root tea and ethanol extraction in hydroxyl radical free radical clearance rate, remove in DPPH free radical, reducing power and inhibition of peroxidation etc. and all have certain effect, and the oxidation resistance of salvia root leaf tea is higher than Radix Salviae Miltiorrhizae leaf and red sage root tea, show through being processed with the raising helping salvia root leaf tea oxidation resistance.

Claims (10)

1. the health tea of the Radix Salviae Miltiorrhizae leaf of an antalgic, it is characterized in that, described Radix Salviae Miltiorrhizae leaf health-care tea comprises the raw material of following weight portion: 10 ~ 50 parts, Radix Salviae Miltiorrhizae leaf, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Fructus Evodiae 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, Rhizoma Corydalis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Radix Urenae Lobatae 10 ~ 20 parts, Herba Duchesneae Indicae 10 ~ 20 parts, Radix Rhodomyrti 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Folium Malloti Apeltae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Pollen Typhae 10 ~ 20 parts, Herba Sedi 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts.

2. the health tea of the Radix Salviae Miltiorrhizae leaf of antalgic according to claim 1, it is characterized in that, the parts by weight of the various raw material of health tea of described Radix Salviae Miltiorrhizae leaf are: 10 ~ 30 parts, Radix Salviae Miltiorrhizae leaf, the Radix Paeoniae Alba 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, Fructus Evodiae 10 ~ 15 parts, Oletum Trogopterori 10 ~ 15 parts, 10 ~ 15 parts, Rhizoma Curcumae Longae, Rhizoma Corydalis 10 ~ 15 parts, Caulis Spatholobi 10 ~ 20 parts, Radix Urenae Lobatae 10 ~ 20 parts, Herba Duchesneae Indicae 10 ~ 20 parts, Radix Rhodomyrti 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Folium Malloti Apeltae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Pollen Typhae 10 ~ 20 parts, Herba Sedi 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts.

3. the health tea of the Radix Salviae Miltiorrhizae leaf of antalgic according to claim 1, it is characterized in that, the parts by weight of the various raw material of health tea of described Radix Salviae Miltiorrhizae leaf are: 10 ~ 50 parts, Radix Salviae Miltiorrhizae leaf, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Fructus Evodiae 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, 10 ~ 20 parts, Rhizoma Curcumae Longae, Rhizoma Corydalis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Radix Urenae Lobatae 10 ~ 20 parts, Herba Duchesneae Indicae 10 ~ 20 parts, Radix Rhodomyrti 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Folium Malloti Apeltae 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Pollen Typhae 10 ~ 20 parts, Herba Sedi 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts.

4. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of antalgic according to any one of claims 1 to 3, it is characterized in that, the preparation process of described health tea comprises:

A.9 Radix Salviae Miltiorrhizae leaf is plucked the moon to mid-October, the preparation of Radix Salviae Miltiorrhizae leaf;

B. the Radix Salviae Miltiorrhizae leaf fried is kneaded, Titian;

C. other raw material pulverizing described, immersion ethanol are added extraction heat;

D. again by surplus stock extract medical filtration, be condensed into granule, powder or unguentum;

E. concentrated granule, powder or unguentum are mixed with the Radix Salviae Miltiorrhizae leaf prepared, sterilizing is prepared into health care medicinal tea.

5. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of antalgic according to claim 4, it is characterized in that, in described step a, JIUYUE is to the fresh and tender Radix Salviae Miltiorrhizae leaf of picked by hand mid-October, and dry in the sun, parches; Radix Salviae Miltiorrhizae leaf good for dry in the sun is put into the pot that completes and goes green grass or young crops, complete 20-30 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when Radix Salviae Miltiorrhizae leaf color starts jaundice, starts little fire and to stir-fry molding in 20-30 minute.

6. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of antalgic according to claim 4, is characterized in that, in described step b, kneaded by the Radix Salviae Miltiorrhizae leaf fried, then put into fragrance extracting machine Titian 20-30 minute, naturally dries after taking out.

7. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of antalgic according to claim 4, is characterized in that, in described step c, get other raw materials clean dry, in 70 DEG C of baking ovens, dry 8-12h, taking-up is placed in cooling in drying baker, pulverizes 80-100 mesh sieve with pulverizer; To be soaked the particulate matter that sieves in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled half an hour third time, filter, heating is concentrated into paste, stand for standby use.

8. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of antalgic according to claim 4, it is characterized in that, in described steps d, paste extract is placed in 70-90% ethanol and soaks 1-2 hour, 60 DEG C-70 DEG C are heated in water-bath, lixiviate 2h, every 10min stirs once, by filtered through gauze, 50-60% ethanol is added in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, be condensed into pasty state filtrate, then insert in economic benefits and social benefits vacuum concentrator, the unguentum after concentrated adds Mel mediation and makes granule; Or convection drying makes powder.

9. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of antalgic according to claim 4, is characterized in that, in described step e, mixed by the Radix Salviae Miltiorrhizae leaf made, pack after ultraviolet ray sterilization bactericidal with other raw materials of refinement.

10. the preparation method of the Radix Salviae Miltiorrhizae leaf health-care tea of an antalgic according to any one of claims 1 to 3, it is characterized in that, the preparation process of all the other raw materials can also be: get other raw materials and clean roguing, steep in the ethanol of 5-10 times amount, medicated powder is equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill; Filtrate above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds Mel mediation and makes granule; Or convection drying makes powder.