CN105616984A - Crinkle-removing beauty cream containing herba leonurus and preparation method thereof - Google Patents

Crinkle-removing beauty cream containing herba leonurus and preparation method thereof Download PDF

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Publication number
CN105616984A
CN105616984A CN201511030654.XA CN201511030654A CN105616984A CN 105616984 A CN105616984 A CN 105616984A CN 201511030654 A CN201511030654 A CN 201511030654A CN 105616984 A CN105616984 A CN 105616984A
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parts
radix
herba
herba leonuri
skin
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CN201511030654.XA
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杨高林
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Qingdao Anbeikang Biomedical Technology Co Ltd
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Qingdao Anbeikang Biomedical Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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Abstract

The invention provides a crinkle-removing beauty cream containing herba leonurus. The crinkle-removing beauty cream containing herba leonurus is prepared from the following bulk drugs in parts by weight: 10-50 parts of herba leonurus, 10-20 parts of herba centellae, 10-20 parts of radix astragalus membranaceus, 10-20 parts of radix polygonati officinalis, 10-20 parts of radix puerariae, 10-20 parts of radix salvia miltiorrhiza, 10-20 parts of rhizoma polygonati, 10-20 parts of radix trichosanthis, 10-20 parts of safflower carthamus, 10-20 parts of radix paeoniae alba, 10-20 parts of bletilla striata, 10-20 parts of peppermint, 10-20 parts of white poria, 10-20 parts of radix ampelopsis, 10-20 parts of radix angelicae, 10-20 parts of rosa chinensis flower, 10-20 parts of calendula flower, 10-20 parts of radix angelica sinensis, 10-20 parts of apricot kernels, 10-20 parts of rose flowers, 10-20 parts of geranium, 10-20 parts of cortex albiziae, 10-20 parts of white atractylodes rhizome and 10-20 parts of exocarpium benincasae. The crinkle-removing beauty cream containing herba leonurus is capable of stimulating replacement of deep skin cells; the herba leonurus is capable of smoothing skin, softening skin, assisting in solving a cutis laxa phenomenon and ensuring the smoothness and elasticity of skin.

Description

A kind of Herba Leonuri wrinkle removing beauty cream and preparation method thereof
Technical field
The present invention relates to containing the beauty treatment preparation deriving from plant, animal or mineral component, particularly to a kind of Herba Leonuri anti-wrinkle paste and preparation method thereof.
Background technology
Chinese medicine beauty treatment is under the guidance of Chinese medicine rationale, by using beauty treatment oral medicinal herb or the outer a kind of method being used for recovering or improve the physiological function of body. Interior oral administration, from internal benefiting vital QI and blood, adjustment function, makes people's QI and blood abundant, radiant. Outer usage be use medicine directly act on body surface local, it utilizes the performance of medicine, make QI and blood flowing, unimpeded through gas, with reach beauty treatment health care effect. Compared with chemical toilet, Chinese medicine beauty treatment has outstanding feature and advantage. One is that Chinese medicine beauty treatment combines together with Chinese medicine, has significantly functional, and its principle is the same with Chinese medicine, focuses on overall conditioning, emphasizes first to nurse one's health inherence, then will shape in outward, therefore, cosmetic result persistently, stable. Two is with theory of Chinese medical science for instructing, and has theory of Chinese medical science feature, such as organic conception, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, property theory, compound compatibility, has the thinking different from modern cosmetics. Three is have pure natural property, Chinese medicine in cosmetic sunscreen relatively synthetic there is uniqueness and significant advantage, there is the features such as nontoxic, harmless, not carcinogenic.
The beauty treatment Chinese medicine summing up out up to now kind more than totally 300, nearly thousand kinds of prescription of improving looks, its elite can provide effective natural drug therapy for modern beauty. Radix Angelicae Sinensis, Radix Ginseng, the Radix Angelicae Dahuricae, Semen Coicis, Semen Armeniacae Amarum, Semen Persicae, Fructus Lycii, Cortex Phellodendri, Flos Chrysanthemi, Rhizoma Typhonii, Rhizoma Chuanxiong, Bulbus Lilii, Radix Salviae Miltiorrhizae, Semen Euryales etc. are all more common beauty treatment Chinese medicine. Wherein Radix Angelicae Sinensis is warm in nature, sweet in the mouth, pungent. There is the effect invigorated blood circulation, enrich blood, blood circulation, skin nutrition can be accelerated, make skin health ruddy. Radix Ginseng contains volatile oil, ginsenoside, polysaccharide, multiple low molecular peptide aminoacid, the composition such as vitamin B group, vitamin C, can improve the blood circulation of local skin, strengthen the supply of skin-nourishing material, promote the metabolism of skin, keep the bright and clean and moist of skin, thus the effect of delay skin aging can be played.
Margarita is in all age always up the skin protection conditioning skin and losing good merchantable brand that people like, skin can be made fine and smooth, and color is ruddy, without wrinkle. Flos Rosae Chinensis is just often swallowed with conditioning skin and losing according to passing Qing Dynasty the Empress Dowager. Rhizomadioscoreae, Semen Nelumbinis, Bulbus Lilii, Fructus Jujubae all energy strengthening the spleen and nourishing the stomach, nourishing blood to tranquillize the mind so that the moist fitness of skin. The promoting blood flow and remove blood stasis drug such as Flos Carthami, Semen Persicae has and improves skin microcirculation effect, so that the QI and blood of people fills Sheng, radiant. Radix Notoginseng, Radix Salviae Miltiorrhizae can moisten and cleaning skin, dispel skin chloasma and black speck, it is suppressed that seborrheic dermatitis, skin is had delaying senility function. Application Chinese medicine is improved looks, and for oral administration have decoction, powder, unguentum, a medicated wine, and medicinal diet for beautifying etc. Life traditional Chinese medicinal meals cosmetic applications is more, and this is based on the theory of the traditional Chinese medical science " doctor food homology, integration of edible and medicinal herbs " in fact, and the medicine selecting some effect relevant becomes food with food formulation, to reach beauty treatment and the double effects of health care. External is washed, is smoked, and facial film applies, more with facial film application again.
Herba Leonuri, has another name called:, motherwort, Herba Leonuri, nine Rhizoma Paridis, the Muscovitum base of a fruit [1] careless, gloomy, Classification system: Leonurusartemisia (Laur.) S.Y.HuF, for Labiatae, mother wort plant, summer-flowering. Its dry aerial parts are conventional Chinese medicine, and most of China area is all produced, and give birth to or endure cream and use. 1 year or biennial herb whole nation most area all have distribution, are born in hill wasteland, ridge, meadow etc. Plucking when the non-standard-sized sheet of riotous growth flower in summer, acrid in the mouth is bitter, cool, invigorates blood circulation, silts of dispelling, regulating menstruation, disappear water, treats menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.
Herba Leonuri has inducing diuresis to remove edema, shrinks the effect of uterus effect, is that ancient Chinese medicine doctor is for treating gynopathic key medicine. Herba Leonuri can all herbal medicine, effective ingredient be Herba Leonuri element, Herba Leonuri is containing multiple alkaloid and benzoic acid, potassium chloride etc. such as leonurine, stachydrine, leonuridine, leonurinines.
Motherwort formulation has the effect of excited animal uterus, similar to pituitrin, and there is strong and lasting excitation in uterus by Herba Leonuri extractum and decoct, not only can strengthen its contractility, can improve its tensity and shrinkage factor simultaneously.
Herba Leonuri, has another name called motherwort, Herba Leonuri, is a kind of herbaceous plant, bitter, pungent, is slightly cold. Owing to it contains the trace element such as selenium and manganese, can antioxidation, anti-aging, resisting fatigue and anticancer hypertrophy, therefore, have moistening face.
The invention discloses a kind of Chinese medicine anti-wrinkle composition, be made up of Chinese medicinal ingredients. Wherein, Radix Angelicae Sinensis promotes skin metabolism, skin lightening of invigorating blood circulation; The Radix Angelicae Dahuricae, Poria, Semen Armeniacae Amarum whitening and moistening skin; Pseudobulbus Bletillae (Rhizoma Bletillae) consolidation smoothing wrinkle; Flos Rosae Chinensis has whitening convergence granulation promoting, promotes cell regeneration and effect of cicatrix healing, is the treasure of whitening and skin-protecting; Herba Leonuri energy aging resistance, consolidation pore, effect except microgroove, be also the anti-ageing holy product of beauty treatment. There is effect that skin lightening of invigorating blood circulation, whitening are wrinkle resistant, it is adaptable to person in middle and old age, the skin that aging is lax, wrinkle gathers.
Summary of the invention
Described Herba Leonuri anti-wrinkle paste, its described beauty cream can also include the crude drug of following parts by weight: Herba Leonuri 10��30 parts, Herba Centellae 10��15 parts, the Radix Astragali 10��15 parts, Rhizoma Polygonati Odorati 10��15 parts, Radix Puerariae 10��15 parts, Radix Salviae Miltiorrhizae 10��15 parts, Rhizoma Polygonati 10��15 parts, Radix Trichosanthis 10��15 parts, 10��15 parts of Flos Carthami, the Radix Paeoniae Alba 10��15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10��15 parts, Herba Menthae 10��15 parts, Poria 10��15 parts, Radix Ampelopsis 10��20 parts, the Radix Angelicae Dahuricae 10��20 parts, Flos Rosae Chinensis 10��20 parts, Flos Inulae 10��20 parts, Radix Angelicae Sinensis 10��20 parts, 10��20 parts of Semen Armeniacae Amarum, Flos Rosae Rugosae 10��20 parts, Flos Pelargonii 10��20 parts, Cortex Albiziae 10��20 parts, the Rhizoma Atractylodis Macrocephalae 10��20 parts, Exocarpium Benincasae 10��20 parts.
Described Herba Leonuri anti-wrinkle paste, its described beauty cream can also include the crude drug of following parts by weight: Herba Leonuri 10��40 parts, Herba Centellae 10��20 parts, the Radix Astragali 10��20 parts, Rhizoma Polygonati Odorati 10��20 parts, Radix Puerariae 10��20 parts, Radix Salviae Miltiorrhizae 10��20 parts, Rhizoma Polygonati 10��20 parts, Radix Trichosanthis 10��20 parts, 10��20 parts of Flos Carthami, the Radix Paeoniae Alba 10��20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10��20 parts, Herba Menthae 10��20 parts, Poria 10��20 parts, Radix Ampelopsis 10��15 parts, the Radix Angelicae Dahuricae 10��15 parts, Flos Rosae Chinensis 10��15 parts, Flos Inulae 10��15 parts, Radix Angelicae Sinensis 10��15 parts, 10��15 parts of Semen Armeniacae Amarum, Flos Rosae Rugosae 10��15 parts, Flos Pelargonii 10��15 parts, Cortex Albiziae 10��15 parts, the Rhizoma Atractylodis Macrocephalae 10��15 parts, Exocarpium Benincasae 10��15 parts.
For solving above-mentioned technical problem, the preparation method that the present invention also provides for a kind of Herba Leonuri anti-wrinkle paste, its described beauty cream preparation method comprises the following steps:
A. the preparation of Herba Leonuri, extracts, as component 1;
B. take Herba Menthae, the Rhizoma Atractylodis Macrocephalae, the Radix Angelicae Dahuricae and the Pseudobulbus Bletillae (Rhizoma Bletillae) way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 2;
C. by all the other crude drug ethanol extraction 2 times, concentrated extracting solution is merged, as component 3;
D., component 1, component 2 add after mixing with component 3 substrate propolis be in harmonious proportion, cold preservation after sterilization tinning.
In described step a, it is possible to pluck when the non-standard-sized sheet of riotous growth flower in summer, the Herba Leonuri plucked is dried, chopping, cross 80-100 mesh sieve.
In described step a, farther including the step extracted, be placed in lid stainless steel cask by the Herba Leonuri of chopping, added 70% ethanol, quality is 0.8-1 times of coarse powder, stirs, and moistening airtight placement more than 1 hour makes abundant expansion; Drug sample after moistening expansion is mixed after paving pine by filter plate gauze bag parcel again bottom percolator do to dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, 2/3 eminence that must not exceed percolator loaded by medicated powder; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow 2��3ml per minute, filtrate puts into liquid container, and ethanol during by emptying pours liquid container into; Being merged by percolate and stand, heating is concentrated into paste, stand for standby use, becomes component 1.
In described step b, it is possible to take Herba Menthae, the Rhizoma Atractylodis Macrocephalae, the Radix Angelicae Dahuricae and the Pseudobulbus Bletillae (Rhizoma Bletillae) way of distillation and be vaporized into crystallization, pulverized 120-150 order dusting cover stand-by, as component 2.
In described step c, all the other raw materials described can be added soak with ethanol 4-6 hour that accounts for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, united extraction liquid, supernatant is removed after standing, then 100-120 order filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 then through damming, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, standing is put in economic benefits and social benefits vacuum concentrator and is mixed, and first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, then inserts 0��5 DEG C of deepfreeze 24 hours; The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g extractum, as component 3.
In described step d, it is possible to three kinds of component mixing above-mentioned steps extracted, stirring, heating, mediation substrate, substrate selects propolis, ultraviolet sterilization bottling cold preservation.
The using method of described Herba Leonuri anti-wrinkle paste, owing to this anti-wrinkle paste is without preservative, so necessary cold preservation, every time just before going to bed after face cleaning, by anti-wrinkling cream uniform application in face, and by middle finger finger belly face message 15-20 minute, after fully absorbing to it, getting up early in second day washes away.
Herba Leonuri, has another name called motherwort, Herba Leonuri, is a kind of herbaceous plant, bitter, pungent, is slightly cold. owing to it contains the trace element such as selenium and manganese, can antioxidation, anti-aging, resisting fatigue and anticancer hypertrophy, therefore, there is the skin care merit present invention with reference to the achievement of Chinese medicine pharmacological research at all times, screening Glycerin, inrigorating qi and promoting blood circulation, liver heat removing and eyesight improving, nourishing liver and kidney, improving acuity of vision and removing nebula, suppressing the hyperactive liver and subsiding YANG, the natural Chinese medicine that detumescence dewaters, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, regulate the metabolism function of human body, improve human facial skin's blood circulation, thus reaching to remove wrinkle, compact skin, eliminate skin texture, detumescence blood stasis dispelling, fatigue alleviating, compact skin around the eyes, desalination eye pouch, reduce wrinkle, beautify the purpose of appearance. the present invention can stimulate deep skin cell to substitute. the present invention can make skin limber up, and contributes to solving cutis laxa phenomenon, makes skin smooth flexible, promoting that in skin corium, collagen protein is formed, and makes fibrin regenerate, reconnect is got up, and makes skin reach smooth effect of compacting. also assist in impaired organization healing and consolidation skin.
Detailed description of the invention
Chinese medicine beauty treatment is under the guidance of Chinese medicine rationale, by using beauty treatment oral medicinal herb or the outer a kind of method being used for recovering or improve the physiological function of body. Interior oral administration, from internal benefiting vital QI and blood, adjustment function, makes people's QI and blood abundant, radiant. Outer usage be use medicine directly act on body surface local, it utilizes the performance of medicine, make QI and blood flowing, unimpeded through gas, with reach beauty treatment health care effect. Compared with chemical toilet, Chinese medicine beauty treatment has outstanding feature and advantage. One is that Chinese medicine beauty treatment combines together with Chinese medicine, has significantly functional, and its principle is the same with Chinese medicine, focuses on overall conditioning, emphasizes first to nurse one's health inherence, then will shape in outward, therefore, cosmetic result persistently, stable. Two is with theory of Chinese medical science for instructing, and has theory of Chinese medical science feature, such as organic conception, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, property theory, compound compatibility, has the thinking different from modern cosmetics. Three is have pure natural property, Chinese medicine in cosmetic sunscreen relatively synthetic there is uniqueness and significant advantage, there is the features such as nontoxic, harmless, not carcinogenic.
The beauty treatment Chinese medicine summing up out up to now kind more than totally 300, nearly thousand kinds of prescription of improving looks, its elite can provide effective natural drug therapy for modern beauty. Radix Angelicae Sinensis, Radix Ginseng, the Radix Angelicae Dahuricae, Semen Coicis, Semen Armeniacae Amarum, Semen Persicae, Fructus Lycii, Cortex Phellodendri, Flos Chrysanthemi, Rhizoma Typhonii, Rhizoma Chuanxiong, Bulbus Lilii, Radix Salviae Miltiorrhizae, Semen Euryales etc. are all more common beauty treatment Chinese medicine. Wherein Radix Angelicae Sinensis is warm in nature, sweet in the mouth, pungent. There is the effect invigorated blood circulation, enrich blood, blood circulation, skin nutrition can be accelerated, make skin health ruddy. Radix Ginseng contains volatile oil, ginsenoside, polysaccharide, multiple low molecular peptide aminoacid, the composition such as vitamin B group, vitamin C, can improve the blood circulation of local skin, strengthen the supply of skin-nourishing material, promote the metabolism of skin, keep the bright and clean and moist of skin, thus the effect of delay skin aging can be played.
Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body are operated, QI-blood circulating regularly freely balances as expensive, if QI and blood is not smooth will produce blood stasis, blood stasis hinders in internal, will further result in the deterioration of qi-blood circulating, cause more serious stasis of blood plug, therefore the traditional Chinese medical science is with QI and blood for guiding principle, by regulating qi and activating blood so as to smoothness balances, can disease-relieving and physique enhancing, beauty treatment of nourishing blood. Skin speckle basic in the stasis of blood, move back speckle must first blood stasis dispelling, blood stasis dispelling when invigorating blood circulation, invigorate blood circulation more must QI invigorating, regulate the flow of vital energy, qi being the governor of blood, blood runs therewith; Blood is keeping of gas, that be so incensed that and quiet, depressed then blood clotting, the deficiency of vital energy then blood prostration, and gas is compeled then blood and walked. QI and blood and then all and. And regulate the flow of vital energy liver, QI invigorating is at lung kidney, lung governing skin and hair. Because of qi depression to blood stasis, have influence on the QI-blood circulation function of lung spleen Liver and kidney, and cause face and occur alopecia, alopecia areata even occurring the mottles such as chloasma, black eye, eye pouch, eye edema, freckle.
The effect of Herba Leonuri: the effect to uterus: the isolated uterine of the many animals such as rabbit, cat is had excitation by Herba Leonuri decoct, ethanol extract and leonurine.
Antiplatelet aggregation and antithrombus formation: experiment in vitro proves, Herba Leonuri and extract thereof have the antagonism ADP intact animal's platelet aggregation induced. Experiment in vivo also proves that Herba Leonuri can substantially reduce the total number of blood platelet in peripheral circulation and platelet and aggregation thereof in alveolar wall blood capillary. Rabbit pulmonary circulation red thrombus is had notable dissolution by Herba Leonuri. Additionally, Herba Leonuri also has the effects such as the cellular immunization of enhancing body.
There is the effect improving coronary circulation and cardioprotection: Herba Leonuri can promote the quickly recovery of the regional flow's microcirculation disturbance caused by isoproterenol. To cardiovascular effect: Herba Leonuri, to isolated guinea pig heart, causes myocardial infarction and ischemia model with isoproterenol, coronary flow and decreased heart rate quite significantly can be dramatically increased. Intravenous motherwort formulation makes anesthetized dog substantially increase coronary flow, reduces coronary resistance, the effect of decreased heart rate and minimizing output and left ventricular work.
Herba Centellae has a heat-clearing and toxic substances removing, inducing diuresis and reducing edema, nourishing, antiinflammatory, quelling effect. Deep skin cell can be stimulated to substitute. Herba Centellae can be compacted epidermis and corium coupling part, skin can be made to limber up, contribute to solving cutis laxa phenomenon, make skin smooth flexible; Promoting that in skin corium, collagen protein is formed, and makes fibrin regenerate, reconnect is got up, and makes skin reach smooth effect of compacting. Also assist in impaired organization healing and consolidation skin. Being closely connected between epidermis with corium can be promoted, the increase of adipose cell can be suppressed again, it is prevented that hydroderma, appearance obesity. Herba Centellae is applicable to various skin quality, and the water extract of its plumelet has the effect of anti-inflammation, and it belongs to dicotyledon Umbelliferae, and energy subduing swelling and detoxicating is dispelled abscess.
The Radix Astragali based on qi-restoratives, can invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation. Cave in for insufficiency of vital energy and blood, skin infection, difficulty in discharging of pus or burst for a long time and do not hold back person. The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time. Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can be used for preventing the generation of some infectious disease. " book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rush down YIN-fire, removes lung-heat, lossless, sends out, and has antiperspirant then to stop. " it is the good medicine promoting resistance and defence disease.
The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant. Controlling the chest and abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, and married woman's blood closes obstructed, repercussive blood, can lose pus, benefit woman's blood. " Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, bring down a fever, relieving restlessness, QI invigorating, the hot disease of sky row, and pestilence miasma, mania and irritation, married woman's blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula. Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat. The many QI invigorating of redness of the skin or complexion person, white person controls blood.
Pseudobulbus Bletillae (Rhizoma Bletillae) property is bitter, sweet, puckery, is slightly cold. Return lung, liver, stomach warp. Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation. Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage. Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "; Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.
Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature. Attach to the lung and stomach meridians. Expelling wind and cold, sensible pain relieving, detumescence and apocenosis, dampness leukorrhagia stopping. " Japan hanako materia medica ": control conjunctival congestion bulbar conjunctiva polyp and tire patching leakage landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, go face defect scar.
Radix Salviae Miltiorrhizae is bitter, is slightly cold. GUIXIN, Liver Channel. Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness. For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia. For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc. Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea has good effect. " detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, and all generally applicable, only taste Radix Salviae Miltiorrhizae dissipates, and cures mainly same. Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins. Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has expansion blood vessel, improves circulation, releases the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, is beneficial to liver cell regeneration.
Flos Inulae, latin name (Calendulaofficinalis), have another name called Calendula officinalis, asphodel. Calendula officinalis rich in multivitamin, especially vitamin A and vitamin C, pigementation can be prevented, promote skin gloss and elasticity, delaying senility, avoid that skin is lax raw to wrinkle. Also can prevent ciril disease, such as vascular lesion and cancer, more can regulate the flow of vital energy cough-relieving, stomach invigorating, reduce phlegm, prevention of asthma and bronchitis. Almost each position can eat; Its petal has the function of beauty treatment, and flower is containing carotenoid, lycopene, violaxanthin, rubixanthin, volatile oil, resin, lymphatic temperament, malic acid etc. Root is containing amaroid, mountain gold east glycol; Seed is containing glyceride, ceryl alcohol and alkaloid. Putting into can so that hair color be thin out in shampoo.
Herba Menthae, popular name is " lunar caustic grass ", for labiate, namely belongs to other dry herbs together, is born in by hill wetland river more, and rhizome grows wild underground, is a kind of fragrant crop having extraordinary economic worth. Herb green grass or young crops gas fragrance. Leaf, to life, spends little lavender, lip, ties dark violet brown granule fruit after spending. Herba Menthae is one of China's conventional Chinese medicine. It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache. Place is with can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc. Herba Menthae is China's conventional Chinese medicine, and children's tender stem point can make vegetable edible, and herb can be used as medicine again, and cure cold heating laryngalgia, headache, conjunctival congestion with ophthalmalgia, myalgia, and the diseases such as skin rubella is scratched where it itches, measles without adequate eruption are also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition. Herba Menthae contains menthol, this material can fresh breath there is the multiple property of medicine, stomachache, gallbladder problem such as spasm can be alleviated, also there is antisepsis and sterilization, diuresis, reduce phlegm, stomach invigorating and the effect such as aid digestion. A large amount of edible Herba Menthaes may result in insomnia, but low dose of eating conduces to sleep.
Flos Carthami (Classification system: CarthamustinctoriusL.), another name: red blue flower, thorn Flos Carthami, Compositae, Flos Carthami platymiscium, dry tubular flower, orange red, floral tube is narrow carefully, and tip 5 splits, and sliver is narrow linear, flower pesticide yellow, being unified into pipe, exceed outside sliver, its central authorities have stigma to expose. Have special fragrance, mildly bitter flavor. To spend, length of a film, color be scarlet, the soft person of matter is preferred. Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, contribute to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, breast side of body twinge, traumatic injury, skin infection swell and ache curative effect. Blood circulation promoting and blood stasis dispelling, wet dissipation is had to go the effect swollen.
Radix Ampelopsis is the root of vitaceae Radix Ampelopsis, and annual spring, autumn excavate, and removes stem and thin fibrous root, and after cleaning, many rip cuttings become two lobes, pintongs or inclined tab, dry and can be used as medicine. It is cool in nature, and bitter but sweet flavor is pungent, has effect of heat clearing away, removing toxic substances, eliminating stagnation, granulation promoting, pain relieving, is used for treating the diseases such as carbuncle, furuncle, scrofula, scald, pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula.
Radix Trichosanthis, Chinese medicine name. " book on Chinese herbal medicine justice ": medicine what is called Radix Trichosanthis person wantonly, namely cuts into slices with it with the root that withers, has the name of powder, real without powder. Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, and for clearing away heat-fire class medicine, its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, and evacuation of pus is subsided a swelling. Cure mainly: control that calentura is thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity. For treatment diabetes, conventional it with drugs for nourishing yin with the use of, to reach the effect for the treatment of both the principal and secondary aspects of a disease.
Chinese angelica blood supplementing; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation. The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Weight after bloody dysentery; Ulcer sores; Injury from falling down. Motherland's medical science is thought, Radix Angelicae Sinensis sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, invigorating middle warmer has, has benefit in row, for the key medicine in blood. Thus, it can be enriched blood, and can invigorate blood circulation again, both can stimulate the menstrual flow, again can be active. All menoxenias, dysmenorrhea, blood deficiency amenorrhea, shallow complexion, weak anemia, metrorrhagia, postnatal blood stasis, example, through the commonly encountered diseases of women such as (during menstrual onset, occurring that mouth and nose are bled), can use angelica for treating. The most frequently used medicine that Radix Angelicae Sinensis is in the traditional Chinese medical science is used for Baoshang, is best to Anemic patients especially. Body hemopoietic function can also be remarkably promoted, raise erythrocyte, leukocyte and content of hemoglobin
Flos Rosae Chinensis can extract spice. Root, leaf, spend and all can be used as medicine, there is promoting blood circulation and detumescence, eliminating inflammation and expelling toxin effect. And be gynecological's good medicine simply. The traditional Chinese medical science is thought, Chinese rose sweet in the mouth, warm in nature, and entering Liver Channel has effect of promoting blood flow to regulate menstruation, subduing swelling and detoxicating. Owing to the blood stasis dispelling of Flos Rosae Chinensis, circulation of qi promoting, analgesic effect are obvious, therefore it is commonly used for the treatment disease such as menoxenia, dysmenorrhea. Menorrhagia, leucorrhea are many, are decocted in water for oral dose with Flos Rosae Chinensis (or root) 15g or stew Carnis Sus domestica food; Flos Rosae Chinensis 10g, Fructus Jujubae 12g are with decocting, and soup adds proper honey after becoming and takes, and this side is not only fragrant but also sweet, does not seem medicine, and menopausal hot flashes is very effective. Additionally, the conventional soaked tea-drinking of working as of Chinese rose petal of women, or add Instant Drinks in other JIANMEI CHA, also can functions of improving blood circulation and face-beautifying, make people reside permanently in the youth.
Flos Rosae Rugosae: road in " book on Chinese herbal medicine text ": " Flos Rosae Rugosae, turbid clearly and not, and and not violent; easing the affected liver is waken up stomach, and thin gas is invigorated blood circulation, and a surname is logical stops up stagnant and that absolutely not pungent temperature is just dry fraud; disconnected push away among edema caused by disorder of QI medicine, has prompt effect most and the most tractable, fragrant all product; there is no equal " Flos Rosae Rugosae contains 300 various chemical components, such as the alcohol of fragrance, aldehyde, fatty acid, phenol and the oil containing essence and fat, often food Flos Rosae Rugosae goods are waken up stomach with easing the affected liver, have a respite and invigorate blood circulation, looks improving and the skin nourishing, makes us refreshing refreshing. The flower opened at the beginning of Flos Rosae Rugosae and root can be used as medicine, and regulate the flow of vital energy, invigorate blood circulation, Thyme Extract, cure mainly menoxenia, the diseases such as traumatic injury, irritability are had a stomachache, newborn too fat to move pain. The sarcocarp of Rosehips, can be made into fruit jam, has flavour, and fruit contains abundant vitamin C and Citrin, and acute and chronic infectious disease, coronary heart disease, hepatopathy and prevention can be prevented to produce carcinogen etc. The Flos Rosae Rugosae quintessence oil (title Liquor Rosae Rugosae Distillata) refined with the way of distillation with roseleaf and obtain, can activate androgen and sperm. Liquor Rosae Rugosae Distillata can also improve skin texture, blood circulation promoting and metabolism.
Radix Puerariae, Chinese medicine name. For the dry root of legume pueraria lobata, habit claims Herba Gelsemii Elegantis. Autumn, season in winter two excavate, and take advantage of fresh-cut and become sheet or fritter; Dry. Sweet, pungent, cool. There are expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the merit of yang invigorating antidiarrheal. Being usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen. " Bencao Jingshu ": " Radix Puerariae, dismisses the positive bright main medicine of epidemic febrile disease pathogenic heat also, therefore master quenches one's thirst, high fever of the body, and heat is stopped up chest and diaphragm and vomitted. Dispersing and rise, the property of wind medicine also, therefore leads all numbness. " " cold headache is held concurrently stiffness of the nape pain along the spinal column and bone pain person all over, and, it is bright that heresy does not still enter sun to the foot sun yet, therefore without thirsty card, should not take. "
Semen Armeniacae Amarum is the seed of Rosaceae Fructus Pruni, is divided into Semen pruni armeniacae and Semen Armeniacae Amarum, mainly contains protein, fat, sugar, trace amygdaloside. The composition of fat is mainly oleic acid and linoleic acid. Semen Armeniacae Amarum fruit is long on short distance (shortspur), has immature outward appearance. When fruit maturation, the shell of its green can split, and manifests the kernel wrapped in coarse shell, and kernel is yellow and has a lot of duck eye, and shell is hard wooden. Semen Armeniacae Amarum fruit is flattened egg-shape, one end circle, and other end point is covered with the thin skin of brown. Kernel contains the protein of 20%, not starch-containing, after grinding, pressurizeing, and the oils and fats squeezed out, it is about the half of weight own, almond oil is faint yellow, although does not have fragrance, but has effect of softening skin and beauty treatment.
Cortex Albiziae is the dry bark of pulse family (LeguminOsae) plant Herba Albiziae, strips more than summer and autumn, dries and forms [1]. In curling tubular or half tubular, long 40��80cm, thick Cortex Albiziae 0.1��0.3cm. Outer surface taupe brown is to taupe, and nature and flavor are sweet, flat. There is the merit of resolving depression and blood, mind calming, subduing inflammation. There is the effect controlling irritability, melancholy, insomnia, lung abscess, carbuncle, scrofula, injured bone. Deciduous tree, umbrella shape tree crown. Leaf alternate, umbrella room locusta, stamen filigree is just as thread shape, half Bai Banhong, therefore has the title of " Flos Rhododendri Delavayi ", " velvet flowers ".
Rhizoma Polygonati Rhizoma Polygonati (formal name used at school: Polygonatumsibiricum), has another name called: polygonatum sibiricum Redoute, yellow chicken dish, shaft of a writing brush dish, claw ginseng, Rhizoma Polygonati Cirrhifolii, JIZHUASHEN. For HUANGJING ZANYU CAPSULE, rhizome horizontal walk, cylindric, tuberosity expands. Impeller is raw, stockless. Medicinal plants, has spleen reinforcing, the effect of the lung moistening and production of body fluid promoting. The effects such as invigorating the spleen and replenishing QI, moist skin, are suitable for cardiovascular system patient and take.
Exocarpium Benincasae sweet in the mouth, cool in nature. Gui Jing returns spleen, small intestine meridian. Effect inducing diuresis to remove edema. Curing mainly for edema distension, dysuria, summer-heat is thirsty, oliguria with reddish urine. Compendium of Material Medica: Exocarpium Benincasae (injured, burning is ground, wine takes) controls stasis soreness of waist pain. " book on Chinese herbal medicine is new again ": walk skin, dries and chases after wind, spleen reinforcing pathogenic fire purging.
Poria meridian distribution of property and flavor: sweet; Light; Flat. The heart; Spleen; Lung; Kidney channel. Eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming. For dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine. For diarrhea due to hypofunction of the spleen, Poria can spleen invigorating, again can eliminating dampness by diuresis, for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, and Poria is often and the compatibility such as Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae. Poria can be used as again tonifying the lung spleen, controls the adjuvant of the deficiency of vital energy. For disease Poria energy tranquilizing by nourishing the hearts such as cardiopalmus, insomnias, therefore can be used for the diseases such as irritability, cardiopalmus, insomnia, Poria is often and the compatibility such as Radix Ginseng, Radix Polygalae, Semen Ziziphi Spinosae. For cough due to fluid-retention, phlegm-damp enters network, aching pain in shoulder and back Poria can promoting diuresis to eliminate damp pathogen, have again function of invigorating spleen, for insufficiency of the spleen can not transmitting and distributing the fluids, stop the disease of the raw phlegm retention of dimerization, there is therapeutical effect.
The Rhizoma Atractylodis Macrocephalae, Classification system Atractylodesmacrocephala. Another name small wooden raft Ji, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, sheet art, Rhizoma Atractylodis etc., belong to Compositae, [WTBX herbaceos perennial. The nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function. It is distributed mainly on the mountain area wetlands such as Sichuan, Yunnan, Guizhou. The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, and for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement. " medicine origin " is recorded: " dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO, go in taste wet, except gastric heat, strong taste, enter diet, antiabortive. "
Embodiment 1
Pluck when the non-standard-sized sheet of riotous growth flower in summer, the Herba Leonuri plucked is dried, dry preparation, steep into alcohol extraction, as component 1;
Take Herba Menthae, the Rhizoma Atractylodis Macrocephalae, the Radix Angelicae Dahuricae and the Pseudobulbus Bletillae (Rhizoma Bletillae) way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 2;
By all the other raw material Herba Centellaes, the Radix Astragali, Rhizoma Polygonati Odorati, Radix Puerariae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Radix Trichosanthis, Flos Carthami, the Radix Paeoniae Alba, Poria, Radix Ampelopsis, Flos Rosae Chinensis, Flos Inulae, Radix Angelicae Sinensis, Semen Armeniacae Amarum, Flos Rosae Rugosae, Flos Pelargonii, Cortex Albiziae, Exocarpium Benincasae ethanol extraction 2 times, merge concentrated extracting solution, as component 3;
Component 1, component 2 adding after mixing with component 3 substrate propolis be in harmonious proportion, ultraviolet sterilization tinning, the present invention is without preservative, it is necessary to cold preservation.
Embodiment 2:
Pluck when the non-standard-sized sheet of riotous growth flower in summer, the Herba Leonuri plucked is dried, by Herba Leonuri 3500g chopping good for dry in the sun, cross 100-120 mesh sieve, the Herba Leonuri of chopping is equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, make abundant expansion, drug sample after moistening expansion is mixed after paving pine by filter plate gauze bag parcel again bottom percolator do to dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, 2/3 eminence that must not exceed percolator loaded by medicated powder, medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol, air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow 2��3ml per minute, filtrate puts into liquid container, and ethanol during by emptying pours liquid container into, percolate is merged and stands. heating is concentrated into paste, stand for standby use, becomes component 1. Herba Menthae 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Angelicae Dahuricae 1000g and the Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g way of distillation are vaporized into crystallization, pulverize stand-by, for component 2, again by other raw materials Herba Centellae 1000g, Radix Astragali 1000g, Rhizoma Polygonati Odorati 1000g, Radix Puerariae 1000g, Radix Salviae Miltiorrhizae 1000g, Rhizoma Polygonati 1000g, Radix Trichosanthis 1000g, Flos Carthami 1000g, Radix Paeoniae Alba 1000g, Poria 1000g, Radix Ampelopsis 1000g, Flos Rosae Chinensis 1000g, Flos Inulae 1000g, Radix Angelicae Sinensis 1000g, Semen Armeniacae Amarum 1000g, Flos Rosae Rugosae 1000g, Flos Pelargonii 1000g, Cortex Albiziae 1000g, Exocarpium Benincasae 1000g, add soak with ethanol 4-6 hour that accounts for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, united extraction liquid, supernatant is removed after standing, then 100-120 order filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 then through damming, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, stand for standby use. two kinds of filtrates above-mentioned steps extracted, put in economic benefits and social benefits vacuum concentrator and mix, and first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, then inserts 0��5 DEG C of deepfreeze 24 hours, the filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g extractum, becomes component 3. component 1 putting into component 3 in component 2, stirs, heating, mediation substrate propolis, ultraviolet sterilization tinning, the present invention is without preservative, it is necessary to cold preservation.
Embodiment 3
Plucking when the non-standard-sized sheet of riotous growth flower in summer, dried by the Herba Leonuri plucked, by Herba Leonuri 4000g immersion water good for dry in the sun 12 hours, be then placed in extraction pot heated and boiled 1 hour, filter, filtrate is standby; Filtering residue adds water, second time heating, boils 45 minutes, filters, and filtrate is standby; Filtering residue adds water, for the third time heated and boiled half an hour, filters; Three filtrates being combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, becomes component 1; Herba Menthae 1000g, Rhizoma Atractylodis Macrocephalae 1100g, Radix Angelicae Dahuricae 1000g and the Pseudobulbus Bletillae (Rhizoma Bletillae) 1100g way of distillation are vaporized into crystallization, pulverize stand-by, for component 2; Take Herba Centellae 1200g, Radix Astragali 1200g, Rhizoma Polygonati Odorati 1200g, Radix Puerariae 1100g again, Radix Salviae Miltiorrhizae 1200g, Rhizoma Polygonati 1200g, Radix Trichosanthis 1100g, Flos Carthami 1200g, Radix Paeoniae Alba 1100g, Poria 1200g, Radix Ampelopsis 1200g, Flos Rosae Chinensis 1100g, Flos Inulae 1200g, Radix Angelicae Sinensis 1200g, Semen Armeniacae Amarum 1200g, Flos Rosae Rugosae 1100g, Flos Pelargonii 1100g, Cortex Albiziae 1100g, Exocarpium Benincasae 1200g, be soaked in water, heated and boiled 3 times, each 1-2 hour, filters, and filtrate is standby; By in the filtrate suction concentrating under reduced pressure tank merging latter 3 times, being evaporated to relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C; Become component 3, blending ingredients 1 and component 2 component 3, mediation substrate, become gel; Described substrate is selected from: propolis. Ultraviolet sterilization tinning, the present invention is without preservative, it is necessary to cold preservation.
Pharmacological toxicity is tested
Toxicology test:
Test example 1: acute toxicity test of the present invention
One, test material:
Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding. Medicine: cosmetic cream of the present invention.
Two, method:
1, LD50 calculates: adopt improvement karber's method, mice is randomly divided into 5 groups, often group 10, male and female half and half, dissolve lotion, are made into Cmax, by the maximum allowable capacity administration of mice, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), after animal fasting (can't help water) 18 hours, in one day, administration (interval half an hour) at twice, each 0.5ml, observe animal dead situation.
2, maximum tolerated dose measures (MTD value): take mice 20, each 10 of male and female. Tablet adds distilled water dissolve, be made into maximum concentration, by the maximum tolerated dose of animal, can twitch and be as the criterion inject filling hello device. After animal fasting (can't help water) 18 hours, administration (interval half an hour) at twice in one day, each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult's 50Kg body weight consumption. Continuous Observation 7 days after administration.
Three, result of the test:
In LD50 calculates when giving mice with maximum acceptable concentration and maximum allowable capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, seek maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death. Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, it was shown that acute toxicity is minimum, MTD > 18g/Kg.d.
Test example 2: acute skin irritation test of the present invention is reported
1, experiment purpose: the detection present invention is to the stimulation/corrosiveness of laboratory animal skin and intensity
2, material and method:
2.1. tested material title: cosmetic cream of the present invention (embodiment method 2 prepares)
2.2. laboratory animal: one grade of big ear white race rabbit, 10, female, body weight 2.1-2.3kg; Thered is provided by Affiliated Hospital of Qingdao University biology department Experimental Animal Center;
2.3. test method:
Select the healthy rabbits 10 that skin is intact, its spinal column both sides, back were cut by hair in first 24 hours in test, the left and right each about 4cm �� 4cm of unhairing area. Taking tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm �� 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape. Opposite side skin is as blank. After closing 4 hours, dismantling, and go residual tested material with warm water cleaning, 1,24 and 48 hours after removing tested material are observed and are smeared position dermoreaction, and mark.
3, experimental result: any erythema does not occur in laboratory animal skin, red and swollen, inflammation phenomenon.
4, brief summary: judging according to skin wound repair standards of grading in " disinfection technology standard " (1999), animal skin stimulus intensity is belonged to nonirritant by ointment of the present invention.
Embodiment 3: vaginal mucomembranous irritant test result
1. test method:
Laboratory animal is selected 18 above-mentioned healthy rabbits, is randomly divided into three groups, often organize each 6, be respectively as follows: blank, excipient control, cosmetic cream of the present invention after quarantining 3 days. It is placed in excipient control group and tested material treated animal intravaginal with appropriately sized sterilizing cotton sliver leaching with sterile saline and tested material respectively, contacts with vaginal mucosa 6 hours, after 24 hours, put to death animal. Taking-up topical vaginal tissue, observes pathological changes situation.
2, result of the test: vaginal mucomembranous irritant test result
Embodiment 4: skin anaphylactic test result
Using cosmetic cream of the present invention, carry out inducing and exciting contact test, viewing test mice after 24 hours and 48 hours, all loseing skin has the phenomenon such as erythema and edema, with negative control group zero difference. It is shown that dermoreaction intensity is bordering on zero by this unguentum, namely without skin allergic reaction.
Embodiment 5: long term toxicity test data
1, experimental technique
Random for Cavia porcellus part is become 4 groups, often group 15. In guinea pig back spinal column both sides, depilatory is uniformly coated with so that it is depilation scope about 40 square centimeters. Clean depilatory, often organize Cavia porcellus after observing 24 hours and be coated with eye cream 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observing the ordinary circumstance of Cavia porcellus, experiment is put to death animal after terminating and is carried out hematology, blood biochemical and pathological examination.
2, result
Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer. Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range. Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes. Prompting, local skin and whole body important organ are showed no obvious toxic action by Chinese medicine facial cream long-term prescription of the present invention.
Pharmacological experiment
One, the microcirculation experimental technique of the present invention:
1, materials and methods: take 50 mices, be randomly divided into 5 groups, often 10 (male and female half and half) of group, it is a little that matched group every Mus auris dextra is coated with normal saline; Positive controls every Mus auris dextra gives commercially available L'Oreal the multiple crease-resistant moist late frost 30ml that compacts of face, and tested group is external beauty cream 30ml of the present invention. 15min pneumoretroperitoneum injects 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, tail vein injection 0.1% epinephrine 0.1mL/10g subsequently, observes mouse right ear fine motion vein bore (��m) immediately and 0.2mm2 blood capillary net number .t inspection processes experimental data.
2 results and discussion
2.1. on microcirculatory impact
Compared with matched group, mice capillary open number is had showed increased (P < 0.01) by tested group 1; Tested group 2 venule bore and capillary open number are dramatically increased (P < 0.01); Mice fine motion, vein bore and capillary open number all had increase (P < 0.01) by tested group 3; Illustrate to be subject to reagent can improve microcirculation, have function of promoting blood circulation to disperse blood clots (table 1).
The impact on mice fine motion, vein bore and capillary open number of table 1, beauty cream of the present invention
Two, the impact on Oleum Tiglii induced mice auricle edema
Take healthy mice 30, it is randomly divided into 3 groups, i.e. blank group, the multiple crease-resistant moist late frost positive controls of compacting of face of commercially available L'Oreal, beauty cream of the present invention, often group 10, male and female half and half, positive controls and instant component are not smeared, blank group smears isodose normal saline, successive administration 7 days, it is administered latter 0.5 hour in last, survey outside the left in ear of mice and be coated with Oleum Tiglii proinflammatory agent (2% Oleum Tiglii, 20% dehydrated alcohol, 5% distilled water, 73% ether) 0.1ml causes inflammation, cause inflammation and lay a left side with card punch (aperture 6mm) in latter 4 hours, auris dextra sheet, weigh, using left and right auricle weight difference as swelling degree, result is in Table 2.
The table 2 impact (X �� SD) on Oleum Tiglii induced mice auricle edema
Note: compare with matched group: * * P < 0.01; Compare with positive controls: #P < 0.05; By upper table experimental result it can be seen that the present invention has pharmacological action of better subsiding a swelling.
Three. the impact of rat paw edema caused by Carrageenan
Take healthy rat 30, body weight 180-220g, be randomly divided into blank group, multiple crease-resistant moist late frost positive controls, the beauty cream of the present invention of compacting of face of L'Oreal. Often group 10, male and female half and half, sub-cage rearing. Positive controls and drug component of the present invention smear 0.2g other every day, blank group gives the normal saline of same dosage and smears, successive administration 7 days, it is administered latter 30 minutes in last, inflammation is only caused respectively at Rat Right metapedes plantar subcutaneous injection 1% carrageenin suspension 0.1ml/, before causing inflammation and cause the girth that 15,30,60,120,240 minutes survey the Rat Right metapedes sole of the foot after inflammation, and calculate swelling rate [swelling rate=(cause scorching metapedes sole of the foot girth-cause scorching front foot sole of the foot girth)/cause scorching front foot sole of the foot girth �� 100%]; Result is in Table 3.
The impact (X �� SD) of rat paw edema caused by table 3 on Carrageenan
Note: compare with matched group: * * P < 0.01; Compare with positive controls: #P < 0.05; By upper table experimental result it can be seen that medicine group of the present invention has better crease-resistant flat muscle, eliminate the pharmacological action of skin pattern.
3 discuss
Clinical trial
Illustrate: my institute, in JIUYUE, 2014 in JIUYUE ,-2015, uses self-control anti-wrinkle cream, to facial wrinkles, Neck wrinkles, canthus wrinkle, and evident in efficacy, existing report is as follows.
Clinical data: clinic chooses facial wrinkles, canthus wrinkle, Neck wrinkles obvious person 80 example. It is all women. Age 35-55 year, average 41 years old; Unmarried 20 example, the married 60 example, do not educate person 65 example; The course of disease 6 months-20 years, average 9.58 years; Educational level University Culture 45 people, white collar, teacher, cadre, office staff 23 example, other staff 12 example. Readme often stay up late overtime work 43 examples, heredity 35 fall, 20 examples of having a sleepless night, daily maintenance skin person 66 people, laser therapy wrinkle removal 25 people. Clinic is divided into treatment group 40 example, matched group 40 example.
Therapeutic Method: treatment group adopts homemade traditional Chinese drug beauty cream, Fang Yong: Herba Leonuri 30g, Herba Centellae 12g, Radix Astragali 12g, Rhizoma Polygonati Odorati 13g, Radix Puerariae 12g, Radix Salviae Miltiorrhizae 12g, Rhizoma Polygonati 10g, Radix Trichosanthis 11g, Flos Carthami 13g, Radix Paeoniae Alba 12g, Pseudobulbus Bletillae (Rhizoma Bletillae) 11g, Herba Menthae 12g, Poria 12g, Radix Ampelopsis 11g, Radix Angelicae Dahuricae 12g, Flos Rosae Chinensis 12g, Flos Inulae 12g, Radix Angelicae Sinensis 13g, Semen Armeniacae Amarum 12g, Flos Rosae Rugosae 13g, Flos Pelargonii 12g, Cortex Albiziae 11g, Rhizoma Atractylodis Macrocephalae 12g, Exocarpium Benincasae 12g, prepare into facial cream by the method for embodiment 2.
Take matched group, often organize 50 examples, use the multiple crease-resistant moist late frost that compacts of face of commercially available L'Oreal respectively.
Operating process: when carrying out in the flat bed of personnel, with 3% hydrogen peroxide cleaning face, with negative ion atomizer spraying face, coordinate meridian point massage 12 methods to carry out facial massage simultaneously, near the eyes local do emphasis massage, the time be about 10min. after take late frost, be uniformly applied to face, note not doing into eyes, can suitably massage 10-15 minute. Once a day, 15 days courses for the treatment of. After terminating the course for the treatment of, monthly follow up a case by regular visits to 1 time, follow up a case by regular visits to continuously 3 months. Advise patient to eat less during treatment pungent, take a good rest, and disable other beauty care items.
Criterion of therapeutical effect
Effect is obvious: after treating for 2 courses for the treatment of, facial skin is compacted, face wrinkles, and chin compacts, canthus wrinkle is substantially desalinated, and curative effect maintains more than 1 month, and facial skin is slightly improved and compacted, corners of the mouth wrinkle, and chin wrinkle improves, and eyestrain is alleviated; Effective: eye pouch, canthus wrinkle are substantially thin out, disappear more than 50%, the conscious satisfaction of patient, sleep quality is good; Or eye pouch disappears during treatment, but it is bad to follow up a case by regular visits to middle sleep, and overtime work has again recurrence; Invalid: chin, corners of the mouth wrinkle are without significant change, and eye pouch, canthus wrinkle change inconspicuous or unchanged; Or once disappeared more than 50%, but substantially increase the weight of in following up a case by regular visits to, testing crew is unsatisfied with.
Therapeutic outcome: treatment group total effective rate compares with each matched group, difference all has significance (P < 0.01), illustrates that self-control beauty cream curative effect is substantially better than the commercially available anti-wrinkle product that compacts. Refer to table 1
13 groups of Comparison of therapeutic tables (%) of table
Note: compare * P < 0.01 with other each group
Follow-up results follows up a case by regular visits to discovery, and massage person is better than the personage not massaged. Adhere to that result of use is obvious. The invention discloses a kind of Chinese medicine anti-wrinkle composition, be made up of Chinese medicinal ingredients. Wherein, Radix Angelicae Sinensis promotes skin metabolism, skin lightening of invigorating blood circulation; The Radix Angelicae Dahuricae, Poria, Semen Armeniacae Amarum whitening and moistening skin; Pseudobulbus Bletillae (Rhizoma Bletillae) consolidation smoothing wrinkle; Flos Rosae Chinensis has whitening convergence granulation promoting, promotes cell regeneration and effect of cicatrix healing, is the treasure of whitening and skin-protecting; Herba Centellae energy aging resistance, consolidation pore, effect except microgroove, be also the anti-ageing holy product of beauty treatment. There is effect that skin lightening of invigorating blood circulation, whitening are wrinkle resistant, it is adaptable to person in middle and old age, the skin that aging is lax, wrinkle gathers.

Claims (10)

1. a Herba Leonuri anti-wrinkle paste, it is characterized in that, described beauty cream includes the crude drug of following parts by weight: Herba Leonuri 10��50 parts, Herba Centellae 10��20 parts, the Radix Astragali 10��20 parts, Rhizoma Polygonati Odorati 10��20 parts, Radix Puerariae 10��20 parts, Radix Salviae Miltiorrhizae 10��20 parts, Rhizoma Polygonati 10��20 parts, Radix Trichosanthis 10��20 parts, 10��20 parts of Flos Carthami, the Radix Paeoniae Alba 10��20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10��20 parts, Herba Menthae 10��20 parts, Poria 10��20 parts, Radix Ampelopsis 10��20 parts, the Radix Angelicae Dahuricae 10��20 parts, Flos Rosae Chinensis 10��20 parts, Flos Inulae 10��20 parts, Radix Angelicae Sinensis 10��20 parts, 10��20 parts of Semen Armeniacae Amarum, Flos Rosae Rugosae 10��20 parts, Flos Pelargonii 10��20 parts, Cortex Albiziae 10��20 parts, the Rhizoma Atractylodis Macrocephalae 10��20 parts, Exocarpium Benincasae 10��20 parts.
2. Herba Leonuri anti-wrinkle paste according to claim, it is characterized in that, described beauty cream includes the crude drug of following parts by weight: Herba Leonuri 10��30 parts, Herba Centellae 10��15 parts, the Radix Astragali 10��15 parts, Rhizoma Polygonati Odorati 10��15 parts, Radix Puerariae 10��15 parts, Radix Salviae Miltiorrhizae 10��15 parts, Rhizoma Polygonati 10��15 parts, Radix Trichosanthis 10��15 parts, 10��15 parts of Flos Carthami, the Radix Paeoniae Alba 10��15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10��15 parts, Herba Menthae 10��15 parts, Poria 10��15 parts, Radix Ampelopsis 10��20 parts, the Radix Angelicae Dahuricae 10��20 parts, Flos Rosae Chinensis 10��20 parts, Flos Inulae 10��20 parts, Radix Angelicae Sinensis 10��20 parts, 10��20 parts of Semen Armeniacae Amarum, Flos Rosae Rugosae 10��20 parts, Flos Pelargonii 10��20 parts, Cortex Albiziae 10��20 parts, the Rhizoma Atractylodis Macrocephalae 10��20 parts, Exocarpium Benincasae 10��20 parts.
3. Herba Leonuri anti-wrinkle paste according to claim, it is characterized in that, described beauty cream includes the crude drug of following parts by weight: Herba Leonuri 10��40 parts, Herba Centellae 10��20 parts, the Radix Astragali 10��20 parts, Rhizoma Polygonati Odorati 10��20 parts, Radix Puerariae 10��20 parts, Radix Salviae Miltiorrhizae 10��20 parts, Rhizoma Polygonati 10��20 parts, Radix Trichosanthis 10��20 parts, 10��20 parts of Flos Carthami, the Radix Paeoniae Alba 10��20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10��20 parts, Herba Menthae 10��20 parts, Poria 10��20 parts, Radix Ampelopsis 10��15 parts, the Radix Angelicae Dahuricae 10��15 parts, Flos Rosae Chinensis 10��15 parts, Flos Inulae 10��15 parts, Radix Angelicae Sinensis 10��15 parts, 10��15 parts of Semen Armeniacae Amarum, Flos Rosae Rugosae 10��15 parts, Flos Pelargonii 10��15 parts, Cortex Albiziae 10��15 parts, the Rhizoma Atractylodis Macrocephalae 10��15 parts, Exocarpium Benincasae 10��15 parts.
4. the preparation method of Herba Leonuri anti-wrinkle paste as according to any one of claims 1 to 3, it is characterised in that described beauty cream preparation method comprises the following steps:
A. the preparation of Herba Leonuri, extracts, as component 1;
B. take Herba Menthae, the Rhizoma Atractylodis Macrocephalae, the Radix Angelicae Dahuricae and the Pseudobulbus Bletillae (Rhizoma Bletillae) way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 2;
C. by all the other crude drug ethanol extraction 2 times, concentrated extracting solution is merged, as component 3;
D., component 1, component 2 add after mixing with component 3 substrate propolis be in harmonious proportion, cold preservation after sterilization tinning.
5. the preparation method of Herba Leonuri anti-wrinkle paste according to claim 4, it is characterised in that in described step a, plucks when the non-standard-sized sheet of riotous growth flower in summer, is dried by the Herba Leonuri plucked, shred, mistake 80-100 mesh sieve.
6. the preparation method of Herba Leonuri anti-wrinkle paste according to claim 4, it is characterized in that, in described step a, farther include the step extracted, the Herba Leonuri of chopping has been placed in lid stainless steel cask, has added 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, make abundant expansion; Drug sample after moistening expansion is mixed after paving pine by filter plate gauze bag parcel again bottom percolator do to dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, 2/3 eminence that must not exceed percolator loaded by medicated powder; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow 2��3ml per minute, filtrate puts into liquid container, and ethanol during by emptying pours liquid container into; Being merged by percolate and stand, heating is concentrated into paste, stand for standby use, becomes component 1.
7. the preparation method of Herba Leonuri anti-wrinkle paste according to claim 4, it is characterised in that in described step b, take Herba Menthae, the Rhizoma Atractylodis Macrocephalae, the Radix Angelicae Dahuricae and the Pseudobulbus Bletillae (Rhizoma Bletillae) way of distillation and be vaporized into crystallization, pulverized 120-150 order dusting cover stand-by, as component 2.
8. the preparation method of Herba Leonuri anti-wrinkle paste according to claim 4, it is characterized in that, in described step c, all the other raw materials described are added soak with ethanol 4-6 hour that accounts for its quality 5-10 times amount, heating extraction 2 times, each 1-2 hour, united extraction liquid, supernatant is removed after standing, then 100-120 order filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 then through damming, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, standing is put in economic benefits and social benefits vacuum concentrator and is mixed, first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, insert 0��5 DEG C of deepfreeze again 24 hours, the filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g extractum, as component 3.
9. the preparation method of Herba Leonuri anti-wrinkle paste according to claim 4, it is characterised in that in described step d, three kinds of components mixing that above-mentioned steps is extracted, stir, heating, it is in harmonious proportion substrate, substrate selects propolis, ultraviolet sterilization bottling cold preservation.
10. the using method of Herba Leonuri anti-wrinkle paste according to any one of claim 1��8, it is characterized in that, this anti-wrinkle paste is without preservative, necessary cold preservation, every time just before going to bed after face cleaning, by anti-wrinkling cream uniform application in face, and by middle finger finger belly face message 15-20 minute, after fully absorbing to it, getting up early in second day washes away.
CN201511030654.XA 2015-12-31 2015-12-31 Crinkle-removing beauty cream containing herba leonurus and preparation method thereof Withdrawn CN105616984A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107184733A (en) * 2017-07-20 2017-09-22 童国柱 A kind of female wine of rose benefit
WO2018113445A1 (en) * 2016-12-22 2018-06-28 张文健 Rosa chinensis essence nutritional skincare aloe vera gel

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018113445A1 (en) * 2016-12-22 2018-06-28 张文健 Rosa chinensis essence nutritional skincare aloe vera gel
CN107184733A (en) * 2017-07-20 2017-09-22 童国柱 A kind of female wine of rose benefit

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