CN105920379A

CN105920379A - Traditional Chinese medicine eye cream to alleviate pouch and preparation method thereof

Info

Publication number: CN105920379A
Application number: CN201511030600.3A
Authority: CN
Inventors: 杨高林
Original assignee: Qingdao Anbeikang Biomedical Technology Co Ltd
Current assignee: Qingdao Anbeikang Biomedical Technology Co Ltd
Priority date: 2015-12-31
Filing date: 2015-12-31
Publication date: 2016-09-07

Abstract

The invention relates to a traditional Chinese medicine eye cream to alleviate pouch. The eye cream comprises the following raw materials by weight: 10-20 portions of Rhus javanica L., 10-20 portions of Equisetum hiemale, 10-20 portions of soapberry, 10-20 portions of Cineraria repanda, 10-20 portions of myrrh, 10-20 portions of the root of red-rooted salvia, 10-20 portions of peach kernel, 10-20 portions of pseudo-ginseng, 10-20 portions of rhizoma imperatae, 10-20 portions of safflower, 10-20 portions of great burnet, 10-20 portions of common bletilla tuber, 10-20 portions of mint, 10-20 portions of borneol, 10-20 portions of angelica root, 10-20 portions of frankincense, 10-20 portions of hairyvein agrimony, 10-20 portions of Steleophaga and 10-20 portions of Chinese angelica. The invention references ancient and modern pharmacological researchachievements in TCM, screens the natural medicines with the effects of tonifying Qi, invigorating the circulation of blood, clearing liver, improving eyesight, nourishing liver and kidney, eliminating nebula, calming the liver, suppressing yang, clearing away heat and toxic material, subsiding swelling and removing water. The eye cream can strengthen body resistance eliminate evil, relax bowel, detoxify, invigorate blood circulation, eliminating stasis, regulate the body's metabolism and improve blood circulation of the skin around the eyes, so as to reach the goals of relieving swelling and stasis, relieving fatigue, firming eye skin, diluting the pouch and beautifying.

Description

A kind of Chinese medicine eye cream alleviating eye pouch and preparation method thereof

Technical field

The present invention relates to containing the beauty treatment preparation deriving from plant, animal or mineral component, particularly to a kind of Chinese medicine eye cream alleviating eye pouch and preparation method thereof.

Background technology

Everybody has a love of beauty, can hang a big eye pouch estimates it is that whose mood is the most bad on the face.Eye pouch is a kind of stinking athero, and it has a strong impact on the attractive in appearance of people, has the people of eye pouch to seem senile, and it is too fat to move that eye pouch refers to that lower eyelid portion organizes, and takes the shape of a bag and hangs from above.In frame, fat content and the supportive structure of lower eyelid maintain poised state under normal circumstances, when this balance changes owing to capsula adiposa bulbi accumulation is too much or lower eyelid support structure thin is weak, capsula adiposa bulbi is broken through the restriction of lower eyelid and is protruded from outside socket of the eye, i.e. forms the bag-shaped deformity of lower eyelid.Clinical manifestation is that skin of lower eyelid is lax, piles up, capsula adiposa bulbi abjection is hung from above and is taken the shape of a bag, outer canthus position moves down, lower margo palpebrae is the tightst with eyeball laminating, lower margo palpebrae radian increases, moving the tear that overflows outside lower lacrimal point, the aging absorption of facial skeleton causes lower eyelid support structure secondary to relax, and is the main cause of person in middle and old age's eye pouch formation.

Eye pouch is caused due to cutis laxa.This understanding has the biggest representativeness.Through demonstration, it also it is the main cause of eye pouch generation.So, promoting skin tightness is main improvement approach.More satisfactory mode is oral collagen.But do not extravagantly hope and the most thoroughly improve, because the reparation of eye pouch is to need certain process.

Increasing the weight of of eye pouch is owing to hyperliposis causes.This is also great representational understanding, and Orbital septum fat has its normal physiological function, and its major function is protection eyeball.The most also it is one of reason forming eye pouch.Why form " pouch sample " outward appearance, entirely due to caused by the hypotonia of socket of the eye barrier film.The minimizing technology of this eye pouch is just by liposuction of performing the operation.If after operation liposuction, and not carrying out the reparation of socket of the eye barrier film, consequence inevitably results in eye pouch recurrence.If taking out fat in a large number, that necessarily causes the depression of lower eyelid, increases the weight of aged appearance.

Cosmetics can rescue eye pouch.This to analyze in terms of two, if " functional " eye pouch, say, that obvious during eye pouch, time and inconspicuous.Suitably applied nutrition frost class cosmetics are for preventing eye pouch from increasing the weight of to play a role.And once eye pouch is " pathologic ", namely organizational structure there occurs change, and eye pouch manifests for a long time, and gradually increases the weight of.If one want to cosmetics are corrected, that is entirely futile effort.Eyes maintenance must be carried out in advance, the outer physiologic factor of the few pathologic factor of eye pouch depolarization accounts for the overwhelming majority, a large amount of women ignore the demand to eyes maintenance in the case of health, and after causing starting aging, speed is very fast, and conscious before aging to carry out maintenance extremely important.

Occurring and increasing the weight of of eye pouch is one of old and feeble mark of skin of face.Want to avoid completely the generation of eye pouch, be unrealistic be also impossible.Because aging is the natural law, it is overpowering.But as long as noting a little, it it is the generation being entirely possible to delay and prevent eye pouch.

Cause eye pouch and have six reasons

1, spleen and stomach function weakens, and can cause internal hydrops, causes palpebra inferior to relax, forms eye pouch.

2, liver is one of toxin expelling and hemopoietic system, liver opening at eye, and the problem of liver shows at eyes entirely, if liver cannot clear toxin, will form eye pouch.

3, suffer from a deficiency of the kidney body fluid metabolic obstacle can occur, deficiency of kidney-QI, with the passing of time cause QI and blood smooth, eye pouch occurs.

4, from the point of view of the science of channels and collaterals, palpebra inferior walks stomach warp, and the position of eye pouch is Tongzi point and the SIBAI point place of stomach warp.There is decline in body fluid metabolic function, and stomach function is deteriorated, and makes Tongzi point and SIBAI point obstruction be caused.

5, the blood circulation of circumference of eyes easily becomes because of overwork to be retarded by silt, and blood vessel refluxes not smooth owing to silting up, causes lymph metabolism to slow down, makes unnecessary moisture and accumulation of blood below eyes, then form eye pouch.

6, skin hydropenia is serious, and each cell of skin is required for enough nutrients, when skin does not has enough hydrones for a long time to prop up, also results in the lax of skin change, causes eye pouch occur or increase the weight of.

Theory of Chinese medical science thinks that the generation of major part eye edema is relevant with Liver and kidney void, after Liver and kidney void, kidney essense can not nourishing the liver blood, and " liver opening at eye ", finally because of essence and blood loss, show and on eyes, be formed for black eye, ocular edema.And modern study also confirms that eye edema is owing to often staying up late, emotional instability, eye strain, aging, cause vein blood vessel blood flow rate the slowest, eye part skin red blood cell is for hypoxgia, and in vein blood vessel, carbon dioxide and metabolic waste accumulation too much, form chronic hypoxia, blood is dark and forms delay and causes eye pigmentation, and eye edema.This matches with theory of Chinese medical science.Eye pouch can pass through operative correction.Laser also can improve eye pouch, promotes the metabolism of skin, promotes the circulation of blood, lymph circulation, makes the desalination slowly of deep eye pouch, and about course for the treatment of just can be appreciated that obvious laser beautifying goes the effect of eye pouch later.Laser goes eye pouch to be belonging to noinvasive beauty treatment, need not anesthesia, laser goes eye pouch other can have the red and swollen phenomenon in local after administering the treatment, this belongs to normal phenomenon, the nursing of circumference of eyes and daily maintenance if worked good, effect can be more lasting, but expensive, and have certain risk, be not everyone can bear rise.

Summary of the invention

The technical problem to be solved is, along with the growth at age, spleen and stomach function weakens, and can cause internal hydrops, causes palpebra inferior to relax, forms eye pouch；Liver opening at eye, the problem of liver shows at eyes entirely, if liver cannot clear toxin, will form eye pouch.Suffer from a deficiency of the kidney and body fluid metabolic obstacle can occur, deficiency of kidney-QI, with the passing of time cause QI and blood not smooth, eye pouch occurs.

Though clinical laser has certain curative effect, but expensive, there is side effect in various degree or cause some complication；Chinese medicine product then because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical efficacy is good and enjoys favor.But existing prescription specific aim is poor, it is impossible to fundamentally alleviate eye pouch, and the most certain side effect.Therefore, the Chinese medicine eye cream finding a kind of highly effective and safe becomes the urgent needs of people.

For solving these technical barriers, the invention provides a kind of Chinese medicine eye cream alleviating eye pouch, its described Chinese medicine eye cream can include the crude drug of following parts by weight: Fructus rhois chinensis 10～20 parts, Herba Equiseti Hiemalis 10～20 parts, Fructus Sapindi Mukouossi 10～20 parts, Herba Senecionis Scandentis 10～20 parts, Myrrha 10～20 parts, Radix Salviae Miltiorrhizae 10～20 parts, Semen Persicae 10～20 parts, Radix Notoginseng 10～20 parts, Rhizoma Imperatae 10～20 parts, Flos Carthami 10～20 parts, Radix Sanguisorbae 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Menthae 10～20 parts, Borneolum Syntheticum 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Olibanum 10～20 parts, Herba Agrimoniae 10～20 parts, Eupolyphaga Seu Steleophaga 10～20 parts, Radix Angelicae Sinensis 10～20 parts.

The Chinese medicine eye cream of described alleviation eye pouch, the parts by weight of its described Chinese medicine eye cream Central Plains material medicine can also be: Fructus rhois chinensis 10～15 parts, Herba Equiseti Hiemalis 10～15 parts, Fructus Sapindi Mukouossi 10～15 parts, Herba Senecionis Scandentis 10～15 parts, Myrrha 10～15 parts, Radix Salviae Miltiorrhizae 10～15 parts, Semen Persicae 10～15 parts, Radix Notoginseng 10～15 parts, Rhizoma Imperatae 10～15 parts, Flos Carthami 10～15 parts, Radix Sanguisorbae 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Menthae 10～20 parts, Borneolum Syntheticum 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Olibanum 10～20 parts, Herba Agrimoniae 10～20 parts, Eupolyphaga Seu Steleophaga 10～20 parts, Radix Angelicae Sinensis 10～20 parts.

The Chinese medicine eye cream of described alleviation eye pouch, the parts by weight of its described Chinese medicine eye cream Central Plains material medicine can also be: Fructus rhois chinensis 10～20 parts, Herba Equiseti Hiemalis 10～20 parts, Fructus Sapindi Mukouossi 10～20 parts, Herba Senecionis Scandentis 10～20 parts, Myrrha 10～20 parts, Radix Salviae Miltiorrhizae 10～20 parts, Semen Persicae 10～20 parts, Radix Notoginseng 10～20 parts, Rhizoma Imperatae 10～20 parts, Flos Carthami 10～20 parts, Radix Sanguisorbae 10～15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 parts, Herba Menthae 10～15 parts, Borneolum Syntheticum 10～15 parts, the Radix Angelicae Dahuricae 10～15 parts, Olibanum 10～15 parts, Herba Agrimoniae 10～15 parts, Eupolyphaga Seu Steleophaga 10～15 parts, Radix Angelicae Sinensis 10～15 parts.

For solving above-mentioned technical problem, the present invention also provides for the preparation method of a kind of Chinese medicine eye cream alleviating eye pouch, and its described preparation method comprises the following steps:

A. take Herba Menthae, Myrrha, Herba Senecionis Scandentis, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae and the Borneolum Syntheticum way of distillation and be vaporized into crystallization, pulverize dusting cover stand-by, as component 1；

B. surplus stock medicinal alcohol is extracted, merge concentrated extracting solution；

C. stripped for above-mentioned steps ethanol extracting solution is condensed into extractum, as component 2；

D. adding substrate with component 2 after component 1 being mixed to be in harmonious proportion, sterilize tinning.

In described step a, first crude drug Herba Menthae, Myrrha, Herba Senecionis Scandentis, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae can be distilled with Borneolum Syntheticum steam method, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1.

In described step b, can be shredded by remaining crude drug, be soaked and be placed in lid stainless steel cask, add 70% ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow per minute 2～3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container；Percolate is merged and stands, stand for standby use.

In described step c, the extracting solution that above-mentioned steps can be extracted, put in economic benefits and social benefits vacuum concentrator and mix, first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml extractum Han 0.1g, becomes component 2.

In described step d, component 1 can be put in component 2, stir, heating, mediation substrate, become cream.

In described step e, described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline.

Described alleviation eye pouch, the Chinese medicine eye cream of eye edema, its using method is, the most just before going to bed after face cleaning, by eye cream uniform application near the eyes, and is massaging near the eyes 15-20 minute by middle finger finger belly, and after fully absorbing to it, getting up early in second day washes away.

The present invention is with reference to the achievement of Chinese medicine pharmacological research at all times, screening inrigorating qi and promoting blood circulation, liver heat removing and eyesight improving, nourishing liver and kidney, improving acuity of vision and removing nebula, suppressing the hyperactive liver and subsiding YANG, heat-clearing and toxic substances removing, detumescence are except the natural Chinese medicine of water, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, the metabolism function of regulation human body, improves human body periocualr skin blood circulation, thus reaches subside a swelling blood stasis dispelling, fatigue alleviating, eye skin of compacting.Desalination eye pouch, beautifies the purpose of appearance.The present invention, according to Traditional Chinese medical theory and modern pharmacological research result, repeated screening medicine for external use, is configured to Chinese medicine eye cream, has blood circulation promoting and blood stasis dispelling, improving acuity of vision and removing nebula, temperature promoting blood circulation, and skin-active is subsided a swelling, blood-nourishing and freckle-removing, the effect of the skin that compacts.Can effectively expand peripheral vessel, improve face microcirculation near the eyes, blood stasis dispelling of subsiding a swelling, pigmentation is had certain inhibitory action.Therapeutic effect of the present invention is more satisfactory, and non-toxic and safe, and preparation method is simple and easy to do, can create good social benefit and economic benefit.

Detailed description of the invention

Cosmetics can rescue eye pouch.This to analyze in terms of two, if " functional " eye pouch, say, that obvious during eye pouch, time and inconspicuous.Suitably applied nutrition frost class cosmetics are for preventing eye pouch from increasing the weight of to play a role.And once eye pouch is " pathologic ", namely organizational structure there occurs change, and eye pouch manifests for a long time, and gradually increases the weight of.If one want to cosmetics are corrected, that is entirely futile effort.Eyes maintenance must be carried out in advance, the outer physiologic factor of the few pathologic factor of eye pouch depolarization accounts for the overwhelming majority, a large amount of women ignore the demand to eyes maintenance in the case of health, and after causing starting aging, speed is very fast, and conscious before aging to carry out maintenance extremely important.Its outstanding maintenance can usefulness be formed frivolous such as the moistening sebum film of yarn at skin surface, produces remarkable moistening effect, keeps skin youth moistening.

Motherland's medical science is thought, this pathogenetic endogenous cause of ill is dirty with liver,spleen,kidney three and QI-blood circulation not normal in close relations, therefore treatment by oral administration of medicines internal organs many from liver spleen kidney by controlling, but be also the external reflection of body interior dysequilibrium.So will be from entirety in treatment, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Liver spleen essence and blood is full, punching appoints tune smooth, then the money of medicine carrying had by oneself by blood network.Liver controlling conveyance and dispersion, can adjust and reach QI and blood, happy feelings will.If depression of liver-QI, qi-blood disharmony. qi depression to blood stasis.Stop up stagnant channels, on tie and then cause speckle in face.Liver storing blood.Liver blood fill and, then body be good for face profit.If deficiency of the liver and kindey, blood and essence asthenia, it is impossible to upper Rong Ze easy dough speckle.

Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body are operated, QI-blood circulating regularly freely balances as expensive, if QI and blood is the most smooth will produce blood stasis, blood stasis hinders in internal, will further result in the deterioration of qi-blood circulating, cause more serious stasis of blood plug, therefore the traditional Chinese medical science is with QI and blood as guiding principle, it is allowed to smooth balance by regulating qi and activating blood, can disease-relieving and physique enhancing, beauty treatment of nourishing blood.Skin speckle basic in the stasis of blood, move back speckle must first blood stasis dispelling, blood stasis dispelling when invigorating blood circulation, invigorate blood circulation more must QI invigorating, regulate the flow of vital energy, qi being the governor of blood, blood runs therewith；Blood is keeping of gas, that be so incensed that and quiet, depressed then blood clotting, the deficiency of vital energy then blood prostration, and gas is compeled then blood and walked.QI and blood and then all and.And regulate the flow of vital energy liver, QI invigorating is at lung kidney, lung governing skin and hair.Because of qi depression to blood stasis, have influence on the QI-blood circulation function of lung spleen Liver and kidney, and cause face and the mottles such as chloasma, black eye, eye pouch, eye edema, freckle occur, alopecia, alopecia areata even occur.The present invention mainly identifies and corrects the principle treated according to Chinese medicine, the many doctor chiefs of collection, extensively adopts the strange medicine wonderful recipe in rich receipts area, skims the cream off milk；Choose inrigorating qi and promoting blood circulation, liver heat removing and eyesight improving, nourishing liver and kidney, improving acuity of vision and removing nebula, suppressing the hyperactive liver and subsiding YANG, heat-clearing and toxic substances removing, detumescence except the natural Chinese medicine of water, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, the metabolism function of regulation human body, improve human body periocualr skin blood circulation, thus reach subside a swelling blood stasis dispelling, fatigue alleviating, eye skin of compacting.Desalination eye pouch, beautifies the purpose of appearance.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing receives antiperspirant.Controlling the chest and abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, and married woman's blood closes obstructed, repercussive blood, can lose pus, benefit woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, bring down a fever, relieving restlessness, QI invigorating, the hot disease of sky row, and pestilence miasma, mania and irritation, married woman's blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Pseudobulbus Bletillae (Rhizoma Bletillae) property is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin；Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "；Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, sensible pain relieving, detumescence and apocenosis, dampness leukorrhagia stopping." Japan hanako materia medica ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, go face defect scar.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc..Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea has good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG is controlled gynecopathy, paid no attention to antenatal puerperal, how many through water, and the most generally applicable, only taste Radix Salviae Miltiorrhizae dissipates, and cures mainly same.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, and peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has expansion blood vessel, improves the effect such as circulation, releasing intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, beneficially liver cell regeneration.

Herba Menthae, popular name, " lunar caustic grass ", for labiate, i.e. belongs to other dry herbs together, is born in by hill wetland river more, and rhizome grows wild underground, is a kind of fragrant crop having extraordinary economic worth.Herb green grass or young crops gas fragrance.Leaf, to life, spends little lavender, lip, ties the granule fruit of dark violet brown after spending.Herba Menthae is one of China's conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.Place is with can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc..Herba Menthae is China's conventional Chinese medicine, and children's tender stem point can make vegetable edible, and herb can be used as medicine again, and curing cold heating laryngalgia, headache, conjunctival congestion with ophthalmalgia, myalgia, the diseases such as skin rubella scratches where it itches, measles without adequate eruption, the most effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains menthol, this material can fresh breath there is the multiple property of medicine, stomachache, gallbladder problem such as spasm can be alleviated, also have antisepsis and sterilization, diuresis, reduce phlegm, stomach invigorating and the effect such as aid digestion.A large amount of edible Herba Menthaes may result in insomnia, but low dose of eating conduces to sleep.

Myrrha (Commiphora myrrha Eng1.), has another name called myrrh, for olive subject plant Herba Violae tree or the dry resin of Ha Didingshu.Main product is in Africa Somalia, Ethiopia and India and other places.Gather the white oleo-gum-resin oozed out by bark crack, in air, become rufous and hard nahlock.After smashing, fry to coke black application.Cure mainly chest and abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.There is the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation.Be in the Orient a kind of invigorate blood circulation, blood stasis dispelling, pain relieving, the Chinese medicine of stomach invigorating, raw property or lymphatic temperament disease, such as raw property arthralgia, sciatica, oral cavity pain, has sore throat, cold cough, moist abundant expectoration, bronchiectasis, eczema abscess, menoxenia, dysuria." note doctor allusion quotation ": " hair growing, speckle dispelling disappears trace, and softening the hard mass removes tumor, and except tinea more wound, teeth consolidating is good for gum, removing toxic substances etc..Controlling alopecia capillary, black spot bruise, verruca plana, various eczemas, gingiva is rotten to the corn, and poisonous insect stings wound etc.." Myrrha compatibility Flos Carthami, Myrrha promoting blood circulation and stopping pain, Flos Carthami activating blood and removing stasis stimulates the menstrual flow.Papillary, have invigorate blood circulation, silt of dispelling, stimulate the menstrual flow, effect of pain relieving, with what treatment blood stasis caused by trusted subordinate's pain, dysmenorrhea, puerperal become silted up resistance stomachache and the stasis pain of traumatic injury.

The medicinal herb for Equisetaceae plant Herba Equiseti Hiemalis of Herba Equiseti Hiemalis, Herba Equiseti Hiemalis's (Classification system: Equisetum hyemale L.) has another name called: thousand peak grass, file grass, nib grass, Herba equiseti ramosissimi, Rhizoma seu Herba Elatostematis stewardii, horse Radix Ginseng etc..Herba Equiseti Hiemalis's sweet in the mouth, hardship, property is put down.Return lung, Liver Channel, there is effect of dispelling wind and heat pathogens, improving acuity of vision and removing nebula, hemostasis.Herba Equiseti Hiemalis gathers summer, removes impurity, storage of drying or dry in the shade, the medicinal process of preparing Chinese medicine: remove withered stem and undesirable root, sprays clear water, slightly moisten, cutting, be dried.Cut off section.Wind-dispelling heat-dissipating, expelling pathogenic factors from muscles, nebula removing.Control the raw nebula of mesh, epiphora induced by wind, discharging fresh blood stool, dysentery, de-liver, malaria, laryngalgia, carbuncle." good blessing book on Chinese herbal medicine ": argument disease, nebula removing film.Removing food stagnancy block again, the liver benefiting gallbladder, improving eyesight, treat hemorrhoidal hamorrhage, dysentery relieving and married woman's metrorrhagia." detailed outline ": expelling pathogenic factors from muscles, arresting lacrimation, hemostasis, curing rheumatism, colic, large intestine proctoptosis.

Flos Carthami (Classification system: Carthamus tinctorius L.), another name: red blue flower, thorn Flos Carthami, Compositae, Flos Carthami platymiscium, dry tubular flower, orange red, floral tube is narrow carefully, and tip 5 splits, and sliver is narrow linear, flower pesticide yellow, being unified into pipe, exceed outside sliver, its central authorities have stigma to expose.Have special fragrance, mildly bitter flavor.To spend, length of a film, color be scarlet, the soft person of matter is preferred.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, contribute to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, breast side of body twinge, traumatic injury, skin infection swell and ache curative effect.Blood circulation promoting and blood stasis dispelling, wet dissipation is had to go the effect swollen.

Borneolum Syntheticum, has another name called sheet brain, Fructus Citri tangerinae sheet, Blumeae preparatum Tabellae, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing etc., is to be obtained through steam distillation recrystallization by Compositae Herba Blumeae Balsamiferae stem and leaf or canella Borneolum Syntheticum Camphor tree branch and leaf.The most useful Oleum Terebinthinae obtains through a series of chemical method techniques.It can be used for excess syndrome of stroke coma, for conjunctival congestion and swelling pain, sore throat aphtha, swell and ache for skin infection, do not hold back after bursting etc. " Newly Revised Canon of Materia Medica ": " main trusted subordinate's pathogen, rheumatism is gathered, deaf, improving eyesight, goes conjunctival congestion skin nebula." Compendium of Material Medica: " treatment sore throat, headache, nose, toothache, typhoid fever protrusion of the tongue, children's's pox fall into.Logical all keys, dissipate stagnated fire." " medical center bun want ": " and Borneolum Syntheticum master dissipates stagnated fire, can deep heat, control infantile convulsion, expectorant fan, sore throat, swelling of the tongue, toothache, deafness, breath, conjunctival congestion cataract, pox poison cave in, parasite killing, hemorrhoid, expedite the emergence of, and property is walked and do not kept, also can granulation promoting pain relieving.

Semen Persicae (Semen Persicae), can refer to the core youngster in Semen Persicae；When using as Chinese herbal medicine Semen Persicae, refer in particular to the seed of rosaceous plant Fructus Persicae or Prunus davidiana, another name Radix Fici Hirtae core, almond core, big Semen Persicae, 6～pluck during fruit maturation in July, remove sarcocarp and nucleocapsid, take out seed, dry, there is effect of blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, can be used for amenorrhea, dysmenorrhea, leprosy abdominal mass mass in the abdomen, injury from falling down, dryness of the intestine constipation etc..Anemia of pregnant woman is cautious use of.Clinical observation proves, blood flow is blocked by Semen Persicae, blood obstacle has improvement result, and each internal organs can be made respectively to organize functional recovery normal.

Radix Notoginseng is to be used as medicine with its root, and it is warm in nature, acrid in the mouth, has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", the good reputation of " southern part of the country SHENCAO ".Because season in Chang Chun winter two excavates, it is divided into again " spring seven " and " winter seven ".Described in Qing Dynasty's pharmaceutical texts supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying first, Radix Notoginseng enriches blood first, taste with and merit also etc., therefore claim Panax pseudoginseng, for the most precious person in Chinese medicine." become famous Chinese patent medicine " YUNNAN BAIYAO " at home and abroad and " Pien Tze Huang ", i.e. make with Radix Notoginseng for primary raw material.Cure mainly spitting of blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.

Herba Senecionis Scandentis (Senecio scandens Buch.-Ham.ex D.Don), has another name called Herba Hieracii Umbellati, Herba Senecionis Scandentis, Herba Sidae Rhombifoliae, Kowloon light, nine ridge light.A kind of Chinese herbal medicine, be born under hillside, sparse woods, Lin Bian, roadside, in limes marginis thick grass.Originate in Henan, Shaanxi, Jiangsu, Zhejiang, Guangxi, Sichuan.It is cold in nature, bitter in the mouth, has a heat-clearing and toxic substances removing, improving eyesight, the effect such as antipruritic.It is used for anemopyretic cold, conjunctival congestion and swelling pain, dysentery, skin eczema furuncle.

Fructus Sapindi Mukouossi (Classification system: Sapindus mukorossi Gaertn.), peel contains Saponin, can be for soap, and timber can do boxboard and wooden comb etc..Root, browse, seed: bitter, micro-pungent, cold.Slightly poisonous.Heat clearing away is eliminated the phlegm, eliminating stagnated food and killing intestinal worms.For diphtheria, laryngopharynx swelling and pain, tonsillitis, cough, pertussis, dyspepsia malnutrition due to parasitic infestation；Outer for trichomonas vaginitis.Kernel: pungent is flat.Removing food stagnancy wards off evil.For infantile malnutrition, ascariasis, flatulence in abdomen, halitosis.Antibacterial, anti-dandruff, anticreep, whitening despeckle, the effect of skin care: " Fructus Sapindi Mukouossi can pre-anti-dandruff ", this be exactly common sense for the Chinese of usual traditional, natural washing product at all.Use the hair washing of Fructus Sapindi Mukouossi soap breast, the most effective according to folklore to what prevention alopecia.Tea polyphenols in Fructus Sapindi Mukouossi is water-soluble substances, washes one's face with it and can remove the oils and fats of face, convergence pore, can sterilize, sterilizing, resisting age of skin, daylight middle-ultraviolet lamp can be reduced and radiate damage etc. to skin.Ferulic acid in Fructus Sapindi Mukouossi is the cosmetic factor that scientific circles generally acknowledge, can improve skin quality so that it is exquisiteness, gloss, high resilience.The effects such as the most antibacterial, antiinflammatory, antioxidation, removing free radical, anticoagulation.Fruit acid in Fructus Sapindi Mukouossi can help skin removed to be deposited in the aging cutin of outer layer.

Fructus rhois chinensis, latin name Rhus chinensis Mill. is good nectariferous plant.Root, leaf, flower and fruit all can be used as medicine, and have the hemostasis of heat-clearing and toxic substances removing, relaxing muscles and tendons and activating QI and blood in the collateral, dissipating blood stasis, the effect of relieving diarrhea with astringents.Anacardiaceae plant Fructus rhois chinensis Rhus chinensis Mill. is used as medicine with root, leaf.Root: be used as medicine for " Radix Rhois chinensis ", has wind dispelling, removing dampness, detumescence, effect of softening the hard mass；Cure cold heating, cough, diarrhoea, edema, rheumatic arthralgia, and traumatic injury wound is swollen, and acute mastitis, tinea skin ulcer, disappear alcoholism.The root bark removing cork is " Cortex Rhois chinensis Radicis ", has wind-damp dispelling, dissipating blood stasis blood, effect of heat-clearing and toxic substances removing；Control cough, rheumatic ostalgia, edema, jaundice, traumatic injury, toxic swelling skin ulcer scabies, venom etc..

Rhizoma Imperatae, Chinese medicine name.Dry rhizome for grass Herba Imperatae Imperata cylindrica Beauv.var.major (Nees) C.E.Hubb..Spring, season in autumn two excavate, and clean, dry, and remove fibrous root and film quality sheath, are bundled into wisp." herbal classic ": impairment caused by overstrain void is won, and invigorating the spleen and replenishing QI, except blood stasis, blood close cold and heat, diuresis." not Lu ": lower five types of stranguria, except exopathogenic heat is at the intestines and stomach, quench the thirst hard muscle, married woman's metrorrhagia.Clothes profit people for a long time.Compendium of Material Medica: the emesis all blood of nosebleed, typhoid fever hiccup, lung-heat dyspnea with rapid respiration, edema jaundice, alcoholic intoxication.

Radix Sanguisorbae (Classification system: Sanguisorba officinalis L.) is Rosaceae burnet herbaceos perennial, and Radix Sanguisorbae is also Chinese herbal medicine.Cold in nature, bitter in the mouth acid, nontoxic；Return liver, lung, kidney and large intestine channel.There are cooling blood for hemostasis, heat-clearing and toxic substances removing, train the effects such as clear yin nourishing, detumescence sore." herbal classic ": housewife people's seven kinds of impairments, leukorrheal diseases, pain relieving, except disliking meat, hidroschesis, treat incised wound." not Lu ": only pus and blood, all flaccidity, malignant boil, disappear wine, except quenching one's thirst, mends plug in wound, puerperal absolutely, can make incised wound cream.Main internal hemorrhage due to trauma is more than, insufficiency of blood." property of medicine opinion ": hemostasis dysentery erosion pus.

Olibanum, Chinese medicine name.The resin oozed out for olive subject plant Boswellia carterii Boswellia carterii Birdw. and congener Boswellia bhaurdajiana Birdw. bark.Compendium of Material Medica: " all poison of eliminating carbuncle cellulitis, Tuoli protects the heart, analgesic therapy of invigorating blood circulation, and controls married woman's difficult labour, injured." " Olibanum perfume (or spice) is altered, and can enter heart channel, analgesic therapy of invigorating blood circulation, therefore is ulcer sores, cardiac and abdominal pain key medicine.... all sides of obstetrics multiplex it, also take its merit ear invigorated blood circulation." book on Chinese herbal medicine remittance speech ": " medicine of muscles and tendons relaxing to alleviate pain is also for Olibanum, promoting blood circulation by removing wind.... tumbling down bucket is beaten again, injured muscles and bones, and QI and blood in puerperal attacks thorn again, trusted subordinate's pain, permanent become to take it fragrant pungent wander away with this, and scattered blood evacuation of pus, ventilationization is stagnant for special merit also.”

Herba Agrimoniae, Herba Agrimoniae is to tap season autumn two in herb summer of rosaceous plant Agrimony, cuts off raw with being used as medicine.The traditional Chinese medical science is thought, its nature and flavor are pained and put down, and have astringing to arrest bleeding, qi-restoratives, removing food stagnancy, dysentery relieving, parasite killing, the effect such as removing toxic substances and promoting subsidence of swelling, be used for is treated the multiple hemorrhages such as spitting of blood, haematemesis, has loose bowels more, dysentery, furuncle carbuncle, the parasitosis such as ascarid, cestode and de-power impairment caused by overstrain, spiritlessness and weakness, shallow complexion etc. is demonstrate,proved.

Eupolyphaga Seu Steleophaga, Chinese medicine name.For Corydiidae insecticide eupolyphoge sinensis Eupolyph, aga sin, ensis Walker or the female worm dry body of Ji eupolyphoge sinensis Steleophaga Plancyi (Boleny).There is removing blood stasis, effect of reunion of fractured tendons and bones.For traumatic injury, the injury of tendon and muscle is fractured, blood stasis amenorrhea, and postpartum stagnation is suffered from abdominal pain, addiction abdominal mass mass in the abdomen.

Chinese angelica blood supplementing；Invigorate blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.The all cards of main blood deficiency；Menoxenia；Amenorrhea；Dysmenorrhea；Lump in the abdomen knot is poly-；Metrorrhagia；Asthenia cold abdominalgia；Flaccidity syndrome and arthralgia syndrome；Numbness of the skin；Dryness of the intestine dyschezia；Weight after bloody dysentery；Ulcer sores；Injury from falling down.Radix Angelicae Sinensis gas is light and pungent, thus again can promoting the circulation of blood, regulating menstruation of both can having stimulated the menstrual flow, again can activating collaterals to relieve pain, be especially suitable for women use, be particularly suitable for the diseases such as menoxenia, dysmenorrhea, blood deficiency amenorrhea, be referred to as " gynecological's panacea " by ancients.With Semen Persicae, Flos Carthami, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Rhizoma Chuanxiong compatibility, composition gynecological recipe TAOHONG SIWU TANG, it is usually used in advanced menstruation, dysmenorrhea.

Specific embodiment 1

Herba Menthae 1000g, Myrrha 1000g, Herba Senecionis Scandentis 1000g, Radix Angelicae Dahuricae 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, the Borneolum Syntheticum 1000g way of distillation are vaporized into crystallization, pulverize stand-by, for component 1；Other raw materials Fructus rhois chinensis 1000g, Herba Equiseti Hiemalis 1000g, Fructus Sapindi Mukouossi 1000g, Radix Salviae Miltiorrhizae 1000g, Semen Persicae 1000g, Radix Notoginseng 1000g, Rhizoma Imperatae 1000g, Flos Carthami 1000g, Radix Sanguisorbae 1000g, Olibanum 1000g, Herba Agrimoniae 1000g, Eupolyphaga Seu Steleophaga 1000g, Radix Angelicae Sinensis 1000g, is soaked in water, heated and boiled 3 times, 1-2 hour every time, filtering, filtrate is standby；By in the filtrate suction concentrating under reduced pressure tank merging latter 3 times, being evaporated to relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C；Become component 2, blending ingredients 1 and component 2, mediation substrate, become gel；Described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline, and furnishing eye cream ultraviolet disinfection is bottled.

Specific embodiment 2

Herba Menthae 1200g, Myrrha 1200g, Herba Senecionis Scandentis 1200g, Radix Angelicae Dahuricae 1200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1200g, the Borneolum Syntheticum 1200g way of distillation are vaporized into crystallization, pulverize stand-by, for component 1；Other raw materials Fructus rhois chinensis 1200g, Herba Equiseti Hiemalis 1300g, Fructus Sapindi Mukouossi 1200g, Radix Salviae Miltiorrhizae 1300g, Semen Persicae 1200g, Radix Notoginseng 1200g, Rhizoma Imperatae 1300g, Flos Carthami 1200g, Radix Sanguisorbae 1300g, Olibanum 1300g, Herba Agrimoniae 1200g, Eupolyphaga Seu Steleophaga 1200g, Radix Angelicae Sinensis 1200g, adds soak with ethanol 2-3 hour accounting for its quality 7-10 times, heating extraction 2 times, 1-2 hour every time, united extraction liquid, removes supernatant after standing, then 100-120 mesh filters, the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming again, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C.The medicinal residues of the crude drug crossed by above-mentioned ethanol extraction again add 10 times amount water, heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged and stands, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, mixing two kinds to extract filtrates and insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g, becomes component 2.By component 1 and the merging of component 2, add Pearl 1300g, mediation substrate, become gel；Described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline, and furnishing eye cream ultraviolet disinfection is bottled.

Specific embodiment 3

Herba Menthae 1200g, Myrrha 1200g, Herba Senecionis Scandentis 1200g, Radix Angelicae Dahuricae 1200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1200g, the Borneolum Syntheticum 1200g way of distillation are vaporized into crystallization, pulverize stand-by, for component 1；Take other raw materials Fructus rhois chinensis 1200g, Herba Equiseti Hiemalis 1300g, Fructus Sapindi Mukouossi 1200g, Radix Salviae Miltiorrhizae 1300g, Semen Persicae 1200g, Radix Notoginseng 1200g, Rhizoma Imperatae 1300g, Flos Carthami 1200g, Radix Sanguisorbae 1300g, Olibanum 1300g, Herba Agrimoniae 1200g, Eupolyphaga Seu Steleophaga 1200g, Radix Angelicae Sinensis 1200g, being soaked and be placed in lid stainless steel cask, add 70% ethanol, quality is coarse grained 0.8-1 times, stir, moistening airtight placement more than 1 hour, make fully to expand；By bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then powder is contained with rustless steel spoon, load percolator uniformly, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, controlling percolation speed and be generally 1000g medical material outflow per minute 2～3ml, filtrate puts into liquid container, and pours ethanol during emptying into liquid container；Percolate is merged and stands, stand for standby use；The filtrate of filtration being inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g, for component 2.By component 1 and the merging of component 2, add Pearl 1300g, mediation substrate, become gel；Described substrate is selected from: Tween-80, triethanolamine, propylene glycol, one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline, and furnishing eye cream ultraviolet disinfection is bottled.

Pharmacological toxicity is tested

Acute toxicity testing data

1, experimental technique

Depilatory is uniformly coated with by guinea pig back spinal column both sides, makes unhairing scope about 40 square centimeters.Clean depilatory returns cage to observe 24 hours, often group Cavia porcellus is coated with Chinese medicine eye mask 0.2,0.4 and 0.8ml of the present invention respectively, 92mg, 184mg and 368mg Han crude drug respectively), another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, tests after terminating, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, has no that local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, liver, kidney and depilation skin compare also no significant difference with compareing word.

Result is pointed out, and Chinese medicine eye mask of the present invention, without local irritant effect, also has no that general toxicity shows.Show that Chinese medicine eye mask of the present invention uses safety.

Long term toxicity test data

1, experimental technique

Random for Cavia porcellus part is become 4 groups, often group 15.In guinea pig back spinal column both sides, depilatory is uniformly coated with so that it is depilation scope about 40 square centimeters.Clean depilatory, often organize Cavia porcellus after observing 24 hours and be coated with eye mask 0.2,0.4 and 0.8ml of the present invention respectively, respectively containing crude drug 92,184 and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observing the ordinary circumstance of Cavia porcellus, experiment is put to death animal after terminating and is carried out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks go to hair-fields, have no that local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine eye mask long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Result of the test shows: Chinese medicine eye mask experiment safety of the present invention.

Pharmacological experiment

One, the microcirculation experimental technique of the present invention:

1, materials and methods: take 50 mices, is randomly divided into 5 groups, often 10 (male and female half and half) of group, and it is a little that matched group every Mus auris dextra is coated with normal saline；Positive controls every Mus auris dextra gives commercially available herborist new seven supercilious looks frost (Shanghai herborist cosmetics company limited product), and test component is external eye cream 400mg/kg/h of the present invention.15min pneumoretroperitoneum injects 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, tail vein injection 0.1% epinephrine 0.1mL/10g subsequently, observes mouse right ear fine motion vein bore (μm) immediately and 0.2mm2 blood capillary net number .t inspection processes experimental data.

2 results and discussion

2.1. on microcirculatory impact

Compared with matched group, tested group 1 has showed increased (P ＜ 0.01) to mice capillary open number；Tested group 2 venule bore and capillary open number are dramatically increased (P ＜ 0.01)；Mice fine motion, vein bore and capillary open number all had increase (P ＜ 0.01) by tested group 3；Illustrate to be improved microcirculation by reagent, have function of promoting blood circulation to disperse blood clots (table 1).

Table 1, eye mask of the present invention are on mice fine motion, vein bore and the impact of capillary open number

Two, the impact on Oleum Tiglii induced mice auricle edema

Take healthy mice 30, it is randomly divided into 3 groups, i.e. blank group, new seven supercilious look frost positive controls, eye cream group of the present invention, often group 10, male and female half and half, positive controls and instant component are not smeared, blank group smears isodose normal saline, successive administration 7 days, it is administered latter 0.5 hour in last, survey outside the left in ear of mice and be coated with Oleum Tiglii proinflammatory agent (2% Oleum Tiglii, 20% dehydrated alcohol, 5% distilled water, 73% ether) 0.1ml causes inflammation, cause inflammation and lay a left side with card punch (aperture 6mm) in latter 4 hours, auris dextra sheet, weigh, using left and right auricle weight difference as swelling degree, the results are shown in Table 2.

The table 2 impact (X ± SD) on Oleum Tiglii induced mice auricle edema

Group	Number of animals (only)	Swelling (mg)
			Blank group	10	8.51±1.72
New seven supercilious look frost groups	10	5.64±1.59**
			Eye cream group of the present invention	10	4.12±1.36#

Note: compare with matched group: * * P ＜ 0.01；Compare with positive controls: #P ＜ 0.05；By upper table experimental result it can be seen that eye cream of the present invention has pharmacological action of preferably subsiding a swelling.

Three. the impact of rat paw edema caused by Carrageenan

Take healthy rat 30, body weight 180-220g, be randomly divided into blank group, new seven supercilious look frost positive controls, eye cream group of the present invention.Often group 10, male and female half and half, sub-cage rearing.Positive controls and drug component of the present invention smear 0.2g other every day, blank group gives the normal saline of same dosage and smears, successive administration 7 days, it is administered latter 30 minutes in last, inflammation is only caused respectively at Rat Right metapedes plantar subcutaneous injection 1% carrageenin suspension 0.1ml/, and within 15,30,60,120,240 minutes, survey the girth of the Rat Right metapedes sole of the foot before causing inflammation after cause inflammation, and calculate swelling rate [swelling rate=(causing the scorching front foot sole of the foot girth of inflammation metapedes sole of the foot girth-cause) scorching front foot sole of the foot girth × 100% of/cause]；The results are shown in Table 3.

The impact (X ± SD) of rat paw edema caused by table 3 Carrageenan

Note: compare with matched group: * * P ＜ 0.01；Compare with positive controls: #P ＜ 0.05；By upper table experimental result it can be seen that medicine group of the present invention has the pharmacological action of blood stasis dispelling of preferably subsiding a swelling.

3 discuss

Theory of Chinese medical science thinks that the generation of major part eye pouch is relevant with Liver and kidney void, after Liver and kidney void, kidney essense can not nourishing the liver blood, and " liver opening at eye ", finally because of essence and blood loss, show and on eyes, be formed for lower eyelid edema, eye pouch is the biggest.And modern study also confirms that eye pouch is owing to often staying up late, emotional instability, eye strain, aging, cause vein blood vessel blood flow rate the slowest, eye part skin red blood cell is for hypoxgia, and in vein blood vessel, carbon dioxide and metabolic waste accumulation too much, form chronic hypoxia, blood is dark and forms delay and causes eye eye pouch, the appearance of eye edema, and this matches with theory of Chinese medical science.

Eye pouch should be suited the remedy to the case after being formed, and consults a physician, finds out the cause of disease, treats in time；Keeping in high spirits, reduce mental burden, live a regular life, control tobacco and wine, ensure sufficient sleep, promote QI and blood vigorous, appearance is shone；Strengthen the massage of eye, improve local blood circulation state, reduce congestion and be detained；As being coated with oil-containing and dividing, eye cream that moisture is sufficient, make eye part skin and subcutaneous tissue dynamic, desalinate eye pouch, ocular edema.

The present invention is with reference to the achievement of Chinese medicine pharmacological research at all times, screening inrigorating qi and promoting blood circulation, liver heat removing and eyesight improving, nourishing liver and kidney, improving acuity of vision and removing nebula, suppressing the hyperactive liver and subsiding YANG, heat-clearing and toxic substances removing, detumescence are except the natural Chinese medicine of water, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, the metabolism function of regulation human body, improves human body periocualr skin blood circulation, thus reaches subside a swelling blood stasis dispelling, fatigue alleviating, eye skin of compacting.Desalination eye pouch, beautifies the purpose of appearance.The present invention, according to Traditional Chinese medical theory and modern pharmacological research result, repeated screening medicine for external use, is configured to Chinese medicine eye cream, has blood circulation promoting and blood stasis dispelling, improving acuity of vision and removing nebula, temperature promoting blood circulation, and skin-active is subsided a swelling, blood-nourishing and freckle-removing, the effect of the skin that compacts.Can effectively expand peripheral vessel, improve face microcirculation near the eyes, blood stasis dispelling of subsiding a swelling, pigmentation is had certain inhibitory action.

Clinical trial

Illustrate: eye pouch, eye edema are treated in May ,-2015 in May, 2014, use self-control eye cream by my institute, and evident in efficacy, now report is as follows.

Clinical data: clinic chooses eye pouch obvious person 100 example.The maleest 28 people, women 72 people.Age 28-58 year, average 35.2 years old；Unmarried 32 example, the married 68 example, do not educate person 21 example；The course of disease 6 months-12 years, average 5.33 years；Educational level University Culture 86 people, white collar, teacher, cadre, office staff 55 example, other staff 30 example.Readme is often stayed up late 45 examples of playing games, and heredity 35 is fallen, and 20 examples of having a sleepless night, daily maintenance 67 people near the eyes, laser therapy eye pouch recurs 12 people.Clinic is divided into treatment group 50 example, matched group 50 example.

Therapeutic Method: treatment group uses homemade traditional Chinese drug eye cream, Fang Yong: Fructus rhois chinensis 15g, Herba Equiseti Hiemalis 12g, Fructus Sapindi Mukouossi 11g, Herba Senecionis Scandentis 12g, Myrrha 10g, Radix Salviae Miltiorrhizae 12g, Semen Persicae 12g, Radix Notoginseng 13g, Rhizoma Imperatae 14g, Flos Carthami 12g, Radix Sanguisorbae 12g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Herba Menthae 11g, Borneolum Syntheticum 12g, Radix Angelicae Dahuricae 13g, Olibanum 13g, Herba Agrimoniae 13g, Eupolyphaga Seu Steleophaga 12g, Radix Angelicae Sinensis 11g.It is prepared as eye cream as described in Example 3.

Take eye cream matched group, often organize 50 examples, use new seven supercilious look frosts of commercially available herborist respectively.

Operating process: when carrying out in the flat bed of personnel, with 3% hydrogen peroxide cleaning face, with negative ion atomizer spraying face, coordinate meridian point massage 12 methods to carry out facial massage simultaneously, emphasis massage is done in local near the eyes, takes eye cream, be uniformly applied to eyelid surrounding after time about 10min., it is careful not to do into eyes, can suitably massage 10-15 minute.Once a day, within 1 month, it was 1 course for the treatment of.After the course for the treatment of terminates, monthly follow up a case by regular visits to 1 time, follow up a case by regular visits to continuously 3 months.Advise patient to take a good rest during treatment, and disable other eye cream, eye cream.

Criterion of therapeutical effect

Fully recovering: after treating for 2 courses for the treatment of, eye pouch, eye edema substantially disappear, and curative effect maintains more than 1 month, eyestrain is alleviated；Effective: eye pouch is the most thin out, disappear more than 50%, the conscious satisfaction of patient, sleep quality is good；Or eye pouch disappears during treatment, but it is bad to follow up a case by regular visits to middle sleep, and overtime work has again recurrence；Invalid: eye pouch, eye edema change inconspicuous or unchanged；Or once disappeared more than 50%, but substantially increase the weight of in following up a case by regular visits to, testing crew is unsatisfied with.

Therapeutic outcome: treatment group total effective rate compares with each matched group, difference all has significance (P ＜ 0.01), illustrates that making eye cream curative effect by oneself is substantially better than commercially available eye cream.Refer to table 1

13 groups of Comparison of therapeutic tables of table

Note: compare * P ＜ O.01 with other each group

Follow-up results follows up a case by regular visits to find, massage person is better than the personage not massaged.After recurrence, if being continuing with the most effective.

Illustrate: the present invention is with reference to the achievement of Chinese medicine pharmacological research at all times, screening inrigorating qi and promoting blood circulation, liver heat removing and eyesight improving, nourishing liver and kidney, improving acuity of vision and removing nebula, suppressing the hyperactive liver and subsiding YANG, heat-clearing and toxic substances removing, detumescence are except the natural Chinese medicine of water, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, the metabolism function of regulation human body, improves human body periocualr skin blood circulation, thus reaches subside a swelling blood stasis dispelling, fatigue alleviating, eye skin of compacting.Desalination eye pouch, beautifies the purpose of appearance.The present invention, according to Traditional Chinese medical theory and modern pharmacological research result, repeated screening medicine for external use, is configured to Chinese medicine eye cream, has blood circulation promoting and blood stasis dispelling, improving acuity of vision and removing nebula, temperature promoting blood circulation, and skin-active is subsided a swelling, blood-nourishing and freckle-removing, the effect of the skin that compacts.Can effectively expand peripheral vessel, improve face microcirculation near the eyes, blood stasis dispelling of subsiding a swelling, pigmentation is had certain inhibitory action.

Claims

1. the Chinese medicine eye cream alleviating eye pouch, it is characterised in that described Chinese medicine eye cream includes following The crude drug of parts by weight: Fructus rhois chinensis 10～20 parts, Herba Equiseti Hiemalis 10～20 parts, Fructus Sapindi Mukouossi 10～20 parts, thousand In light 10～20 parts, Myrrha 10～20 parts, Radix Salviae Miltiorrhizae 10～20 parts, Semen Persicae 10～20 parts, Radix Notoginseng 10～20 Part, Rhizoma Imperatae 10～20 parts, Flos Carthami 10～20 parts, Radix Sanguisorbae 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Menthae 10～20 parts, Borneolum Syntheticum 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Olibanum 10～20 parts, Herba Agrimoniae 10～20 parts, Eupolyphaga Seu Steleophaga 10～20 parts, Radix Angelicae Sinensis 10～20 parts.

Alleviate the Chinese medicine eye cream of eye pouch the most according to claim 1, it is characterised in that described Chinese medicine In eye cream, the parts by weight of various crude drug are: Fructus rhois chinensis 10～15 parts, Herba Equiseti Hiemalis 10～15 parts, Fructus Sapindi Mukouossi 10～15 parts, Herba Senecionis Scandentis 10～15 parts, Myrrha 10～15 parts, Radix Salviae Miltiorrhizae 10～15 parts, Semen Persicae 10～15 parts, Radix Notoginseng 10～15 parts, Rhizoma Imperatae 10～15 parts, Flos Carthami 10～15 parts, Radix Sanguisorbae 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～ 20 parts, Herba Menthae 10～20 parts, Borneolum Syntheticum 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, Olibanum 10～20 parts, red crowned crane Grass 10～20 parts, Eupolyphaga Seu Steleophaga 10～20 parts, Radix Angelicae Sinensis 10～20 parts.

Alleviate the Chinese medicine eye cream of eye pouch the most according to claim 1, it is characterised in that described Chinese herb medicine eye In frost, the parts by weight of various crude drug are: Fructus rhois chinensis 10～20 parts, Herba Equiseti Hiemalis 10～20 parts, Fructus Sapindi Mukouossi 10～ 20 parts, Herba Senecionis Scandentis 10～20 parts, Myrrha 10～20 parts, Radix Salviae Miltiorrhizae 10～20 parts, Semen Persicae 10～20 parts, three 7 10～20 parts, Rhizoma Imperatae 10～20 parts, Flos Carthami 10～20 parts, Radix Sanguisorbae 10～15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 Part, Herba Menthae 10～15 parts, Borneolum Syntheticum 10～15 parts, the Radix Angelicae Dahuricae 10～15 parts, Olibanum 10～15 parts, Herba Agrimoniae 10～15 parts, Eupolyphaga Seu Steleophaga 10～15 parts, Radix Angelicae Sinensis 10～15 parts.

4. as according to any one of claims 1 to 3, alleviate a preparation method for the Chinese medicine eye cream of eye pouch, It is characterized in that, described preparation method comprises the following steps:

A. take Herba Menthae, Myrrha, Herba Senecionis Scandentis, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae and the Borneolum Syntheticum way of distillation and be vaporized into crystallization, powder Broken dusting cover excessively is stand-by, as component 1；

Alleviate the preparation method of the Chinese medicine eye cream of eye pouch the most according to claim 4, it is characterised in that In described step a, first crude drug Herba Menthae, Myrrha, Herba Senecionis Scandentis, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae are steamed with Borneolum Syntheticum water Gas method is distilled, and obtains crystal, then pulverizes, and crosses 100-120 mesh sieve, standby as component 1.

Alleviate the preparation method of the Chinese medicine eye cream of eye pouch the most according to claim 4, it is characterised in that In described step b, remaining crude drug is shredded, soaked and be placed in lid stainless steel cask, add 70% second Alcohol liquid, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes to fill Divide and expand；Filter plate gauze bag bottom percolator is wrapped up after paving again by the drug sample after moistening expansion Mix pine to do to dissipate, then contain powder with rustless steel spoon, load percolator uniformly, fill 10-12 cm thick, use T Type rod pressure is even, then presses aforesaid operations, and loading in layer is suitably pressurizeed, and medicated powder loads and must not exceed 2/3 eminence of percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, And put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have Ethanol flows out about about 20L, closes baiting valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve Carrying out percolation, control percolation speed and be generally 1000g medical material outflow per minute 2～5ml, filtrate puts into storage In fluid cylinder, and pour ethanol during emptying into liquid container；Percolate is merged and stands, stand for standby use.

Alleviate the Chinese medicine eye cream preparation method of eye pouch the most according to claim 4, it is characterised in that institute State in step c, the extracting solution that above-mentioned steps is extracted, put in economic benefits and social benefits vacuum concentrator and mix, first will When filtrate is concentrated into 80 DEG C, relative density is the concentrated solution of 1.52, sets to 0～5 DEG C of deepfreezes 24 hours；Will The filter aid kieselguhr that cold preservation liquid adds 0.3%, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, concentrates To every 1ml extractum Han 0.1g, become component 2.

Alleviate the Chinese medicine eye cream preparation method of eye pouch the most according to claim 4, it is characterised in that institute State in step d, component 1 is put in component 2, stirs, heating, mediation substrate, become cream.

Alleviate the Chinese medicine eye cream preparation method of eye pouch the most according to claim 4, it is characterised in that institute Stating in step e, described substrate is selected from: Tween-80, triethanolamine, propylene glycol, semi-synthetic fatty acid One or more in glyceride, poloxamer, Polyethylene Glycol, lanoline.

10. according to any one of claim 1～9, alleviate the Chinese medicine eye cream of eye pouch, it is characterised in that Using method is, the most just before going to bed after face cleaning, by eye cream uniform application near the eyes, and exists by middle finger finger belly Massage 15-20 minute near the eyes, after fully absorbing to it, getting up early in second day washes away.