CN102847063B

CN102847063B - Traditional Chinese medicinal composition for treating qi and blood deficiency blood stasis type diabetic feet, and its preparation method

Info

Publication number: CN102847063B
Application number: CN201210312257.1A
Authority: CN
Inventors: 李玲; 孙向红
Original assignee: 杨高林
Current assignee: CHONGQING XUANNU BIOTECHNOLOGY CO., LTD.
Priority date: 2012-08-28
Filing date: 2012-08-28
Publication date: 2014-07-02
Anticipated expiration: 2032-08-28
Also published as: CN102847063A

Abstract

The invention discloses a traditional Chinese medicinal composition for treating the qi and blood deficiency blood stasis type diabetic feet. The symptoms of the qi and blood deficiency blood stasis type diabetic feet are common in the restoration stage of the diabetic foot disease, and comprise lasting wound disunion, dilute fester, amyotrophy and weakness light tongue nature, thin and white tongue fur, chest distress, purple face, body fatness, feebleness, encrusted affect foot skin, ecchymosis, stiffness, numbness and the like. The composition comprises oral medicines and external medicines, wherein the oral medicines comprise Rhizoma Corydalis, Radix Rehmanniae Preparata, Chinese angelica, Radix Astragali, Achyranthes bidentata, Salvia miltiorrhiza, prepared Polygonum multiflorum Thunb, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Curcumae Aromaticae, safflower, Ligusticum wallichii, Millettia dielsiana, lumbricus, dendrobium, ground beetle, Chinese cassia, Semen Brassicae and Radix Paeoniae Rubra; and the external medicines comprise Manchurian wildginger, Radix Clematidis, Panax Notoginseng, Boswellia carteri, myrrh, rheum officinale, Amur Corktree Bark, dried alum, Glabrous Greenbrier Rhizome, fried Radix Sanguisorbae, safflower, Fructus Cnidii, Bletilla striata and Rhizoma Drynariae. The composition has the efficacies of qi and blood tonifying, channel freeing and blood circulation stimulating, channel warming and cold dispelling, stasis removing and pain relieving, qi and blood benefiting, and internal heat and dysphoria removing when the composition is orally taken, and has the efficacies of blood circulation activating, stasis removing, inflammation removing and flesh engendering when the composition is externally used. On one hand, the local micro-vascular impairment of the lower limbs is improved and the blood circulation is promoted to make necrotic tissues shed as fast as possible in order to reach tissue restoration; on the other hand, the oral medicines can effectively control the blood sugar, adjust the blood viscosity and reduce the blood pressure; and simultaneously the food infection is prevented to enhance the body immunity.

Description

A kind of Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot and preparation method thereof.

Background technology

Over nearly 20 years, the pathogenetic understanding of China's traditional Chinese medical science bound pair diabetic foot in system progressively deeply.Representational doctor points out that the basis of diabetic foot is deficiency of both QI and YIN, and different TCM syndrome types is blood stasis due to qi deficiency, and standard card is that damp and hot heap soil or fertilizer over and around the roots is contained, and the order that the development trend of vascular lesion and syndrome of blood stasis is contained by deficiency of both QI and YIN, blood stasis due to qi deficiency, damp and hot heap soil or fertilizer over and around the roots increases progressively, and the state of an illness also increases the weight of thereupon.During this patient is according to the observation, the aged, without obvious symptom more than three, common uncomfortable in chest, face is purple, fat, weak, suffer from sufficient squamous and dry skin, ecchymosis, stiff, numb etc., pathogenesis is blood stasis stagnation of phlegm, healthy energy is deficient.

Also have doctor to think that primary disease is mainly deficiency of both QI and YIN, passages through which vital energy circulates stasis blocking, due to acra mistake is supported, always belongs to the card of deficiency in origin and excess in superficiality, and taking deficiency of both QI and YIN as this, passages through which vital energy circulates stasis blocking is mark.Spleen, kidney two void, coagulation of QI-blood, meridians intercept, and yang deficiency blood stasis is that primary disease morbidity is basic.Primary disease is started in quenching one's thirst, and belongs to hyperactivity of fire caused by deficiency of YIN, and burn Tianjin blood of heat, leads to blood stasis, cause limbs to lose and support, the evil poison of multiple sense, so acra fester and form necrosis, its basic pathogenesis is weakened body resistance blood stasis, in pyretic toxicity, accumulates.According to the clinical observation to diabetic foot tendon degeneration necrosis disease (muscle cellulitis), point out that its pathogenesis is: old kidney liver degradation, gas is cloudy to be consumed, not removing dampness of gas, not nourishing muscle and tendon of the moon, with the passing of time the rotten poison of muscle damage is cellulitis.Think the early stage deficiency of both QI and YIN of primary disease, venation discord, mid-term, deficiency of qi and blood, accumulate in noxious dampness, late period the hepatic and renal YIN deficiency, stagnation of phlegm blood stasis.

The pathogenesis of diabetic foot mainly ascribes heat and the stasis of blood to, and the cloudy liquid virtual loss of diabetics is raw in deficiency-heat, and the consumption body fluid that burns forms the stasis of blood, or disease damage and sun, so that deficiency of both YIN and YANG, and yang deficiency cold coagulation and cause the stasis of blood; Blockage of the vessel, failure of skin and muscle to be nourished, apathy, is subject to wound, the exopathogen invasion of taking advantage of a weak point in opponent's defence, strongly fragrant and heat-transformation, or because of polyphagia delicious food, endogenous dampness, moist dysentery, damp and hot stasis of blood knot and falling ill mutually.

Diabetic foot refers to the large small artery of diabetics whole body, particularly artery of lower extremity sclerosis of blood vessels causes that thrombosis appears in small artery around, form angiostenosis and obturation, cause patient's foot blood supply insufficiency, add diabetic neuropathy and the foot anaesthesia that causes and a kind of severe complication of damage.Its pathological changes main damage meridians, blood vessel, skin, tendon, even skeleton, makes patient show as intermittent claudication, lower limb tranquillization pain,, even there is foot gangrene and cause amputation to disable in severe patient skin ulceration, withered, blackening.

QI and blood deficiency blood stasis type diabetic foot, this disease is more common in the convalescent period of diabetic foot, the lasting disunion of performance wound surface, pus is rare clearly, amyotrophy weakness, pale tongue, thin white fur of tongue, old kidney liver degradation, gas is cloudy to be consumed, not removing dampness of gas, and not nourishing muscle and tendon of the moon, with the passing of time the rotten poison of muscle damage is cellulitis.Deficiency of both QI and YIN, venation discord, mid-term, deficiency of qi and blood, accumulate in noxious dampness, late period the hepatic and renal YIN deficiency, stagnation of phlegm blood stasis.During patient is, the aged, without obvious symptom more than three, common uncomfortable in chest, face is purple, fat, weak, suffer from sufficient squamous and dry skin, ecchymosis, stiff, numb etc., proposing pathogenesis is blood stasis stagnation of phlegm, healthy energy is deficient.

Because diabetics is for a long time in hyperglycemia state, glycolated hemoglobin is high, and erythrocyte oxygen carrying capacity is poor, and blood viscosity increases, and causes sclerosis of blood vessels, becomes fragile, thickens, and the ability of red blood cell deformation declines, blood supply deficiency; On the other hand, blood viscosity increase also causes vascular inflammation, many reasons above, can cause vascularization thrombosis, cause blood vessel to produce inaccessible phenomenon, cause blood supply seriously to lack, the local organization malnutrition of foot, because " foot " is centrifugal farthest dirty, vascular occlusion phenomenon is the most serious, be easy to cause edema, blackout, rotten, downright bad, form foot necrosis.

Clinical and experiment shows, diabetic gangrene patient's ubiquity stagnation of blood stasis, the pathological change of venation numbness resistance.Show as instep and posterior tibial artery and beat to weaken even and disappear, Abnormal Blood Rheology, whole blood viscosity increases, platelet aggregation ability increases, and clotting mechanism is abnormal, and fibrin increases, fibrinbioplast reduces, microcirculation disturbance, and loop ejects existing tuberosity, pipe loop is smudgy, blood flow anomalies, and broken string presents lumps, hemocyte is assembled, venous plexus expansion under vein loop and nipple, there is ecchymosis etc. in loop week, microcirculation causes abnormal change to embody the essence of traditional Chinese medical science diabetes necrosis.

The traditional Chinese medical science is emphasized " disease is not first controlled, and anti-overweighting controlled ", and the generation of prevent diabetes foot is more urgent and important more than treatment diabetic foot.Research shows to scald and wear improper footgear and prunes toenail improper etc. is the physical factor that causes diabetic foot.Patient should forbid that foot is placed hot water bag or heat pads, and avoids scalding foot; Should wear soft, the loose ventilative shoes of the matter of fitting, avoid light to wear footwear, shoes can not be uneven, have crackle, changes every other day footwear money, in order to avoid the long-term pressurized of foot's same position as far as possible.Can not pass tight shoes and socks, in order to avoid affect the blood circulation of foot: apply file while pruning toenail and with vertical direction, toenail is polished.After foaming foot, apply bibulous towel and softly and thoroughly dry, especially between toe space, should keep dry.Can not Overexertion friction, to avoid skin injury.Therefore strengthen the educational propaganda of pedopathy, the self-foot health promotion consciousness and the ability that improve diabetics are particularly important.

Doctor trained in Western medicine can not solve sufferer misery for this disease at all, diabetic foot (diabetic foot, DF) be modal complication in diabetics, have 15%～25 ulcer of foot in various degree in diabetics, wherein approximately 1% patient is because the development of ulcer is finally by amputation.The cause of disease of DF is Lower Distal Extremities neuropathy due to diabetes and the comprehensive pathological change of Lower Distal Extremities vascular lesion, the pathophysiological change that its skin of lower extremity and tissue injury occur often on the basis of metabolism disorder and blood vessel, neuropathy.Because the complexity of pathological changes changes, cause single therapy not prove effective, conventionally adopt the way of Comprehensive Treatment.In a word, Chinese medicine comprehensive treating diabetes foot has been obtained certain curative effect clinically, has tentatively demonstrated significant advantage; But effectively prescription needs dialectical use, and specific aim is poor, and clinical practice degree is not high.

Summary of the invention

Technical problem to be solved by this invention is, provides one to alleviate patient's slight illness, and wound healing reduces amputation rate, improves patients ' life quality object Chinese medicine composition; The present invention adopts the Chinese crude drug of different properties, qi and blood tonifying for oral administration; Dispelling cold by warming the meridian; Stasis-dispelling and pain-killing; Benefiting vital QI and blood is laid equal stress on; External blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting.Improve on the one hand the local blood capillary obstacle of lower limb, blood circulation promoting, comes off slough as early as possible, reaches tissue repair; Endo-medicine is effectively controlled blood glucose, regulates blood viscosity, is reduced blood pressure on the other hand; To prevent foot to infect, enhancing human body immunity function simultaneously; Oral medicinal herb and external application can improve ulcer surface microcirculation effectively, increase the groundwater increment of local organization, promote the regeneration of inflammation absorption and granulation tissue and epithelium, reach the object of ulcer surface wound healing.Adopt Chinese medicine internal and external application method treatment diabetic foot to shorten the time of ulcer healing, evident in efficacy, clinic is applied.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot, this disease is more common in the convalescent period of diabetic foot, the lasting disunion of performance wound surface, pus is rare clearly, amyotrophy weakness, pale tongue, thin white fur of tongue; Formed by endo-medicine and external used medicine;

In described endo-medicine, the ratio of weight and number of various crude drug can be: 10～20 parts of Rhizoma Corydalis, 10～20 parts, Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts, Poria, 10～20 parts of Radix Curcumaes, 10～20 parts, Flos Carthami, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Caulis Spatholobis, 10～20 parts of Pheretimas, 10～20 parts of Herba Dendrobiis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Cortex Cinnamomis, 10～20 parts of Semen Sinapis Albaes, 10～20 parts of Radix Paeoniae Rubra;

In described external used medicine, the parts by weight of various crude drug can be: 10～30 parts of Herba Asaris, 10～30 parts of Radix Clematidis, 10～30 parts of Radix Notoginseng, 10～30 parts of Olibanums, 10～30 parts of Myrrhas, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 10～30 parts of dried Alumens, 10～30 parts of Rhizoma Smilacis Glabraes, 10～30 parts of Radix Sanguisorbae preparatas, 10～30 parts, Flos Carthami, 10～30 parts of Fructus Cnidiis, 10～30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～30 parts of Rhizoma Drynariae.

The Chinese medicine composition of described treatment QI and blood deficiency blood stasis type diabetic foot, described in it, in endo-medicine, the ratio of weight and number of various crude drug can also be: 10～15 parts of Rhizoma Corydalis, 10～15 parts, Radix Rehmanniae Preparata, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Achyranthis Bidentataes, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts, Poria, 10～20 parts of Radix Curcumaes, 10～20 parts, Flos Carthami, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Caulis Spatholobis, 10～20 parts of Pheretimas, 10～20 parts of Herba Dendrobiis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Cortex Cinnamomis, 10～20 parts of Semen Sinapis Albaes, 10～20 parts of Radix Paeoniae Rubra,

In described external used medicine, the ratio of weight and number of various crude drug can also be: 10～15 parts of Herba Asaris, 10～15 parts of Radix Clematidis, 10～15 parts of Radix Notoginseng, 10～15 parts of Olibanums, 10～15 parts of Myrrhas, 10～15 parts of Radix Et Rhizoma Rhei, 10～15 parts of Cortex Phellodendris, 10～30 parts of dried Alumens, 10～30 parts of Rhizoma Smilacis Glabraes, 10～30 parts of Radix Sanguisorbae preparatas, 10～30 parts, Flos Carthami, 10～30 parts of Fructus Cnidiis, 10～30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～30 parts of Rhizoma Drynariae.

The Chinese medicine composition of described treatment QI and blood deficiency blood stasis type diabetic foot, described in it, in endo-medicine, the ratio of weight and number of various crude drug can be also: 10～20 parts of Rhizoma Corydalis, 10～20 parts, Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts, Poria, 10～15 parts of Radix Curcumaes, 10～15 parts, Flos Carthami, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Caulis Spatholobis, 10～15 parts of Pheretimas, 10～15 parts of Herba Dendrobiis, 10～15 parts of Eupolyphaga Seu Steleophagas, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Semen Sinapis Albaes, 10～15 parts of Radix Paeoniae Rubra,

In described external used medicine, the ratio of weight and number of various crude drug can be also: 10～30 parts of Herba Asaris, 10～30 parts of Radix Clematidis, 10～30 parts of Radix Notoginseng, 10～30 parts of Olibanums, 10～30 parts of Myrrhas, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 10～15 parts of dried Alumens, 10～15 parts of Rhizoma Smilacis Glabraes, 10～15 parts of Radix Sanguisorbae preparatas, 10～15 parts, Flos Carthami, 10～15 parts of Fructus Cnidiis, 10～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～15 parts of Rhizoma Drynariae.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot, the dosage form of described Chinese medicine composition endo-medicine is granule, and its preparation method comprises: described crude drug is put into pulverizer grinding and sieving by a.

B. particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times;

C. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying are dry, obtain medicated powder; Mixing the fine powder obtaining that sieves packs in bag.

In described step a, described crude drug is put into after pulverizer is pulverized and crossed 100-120 order dusting cover, the fine powder amount that enable pass is crossed sieve aperture is reaching 30%-40%, collects by the raw material fine powder of sieve aperture for subsequent use.

In described step b, particulate matter remaining after sieving can be put into 10 times of amount 75% ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution be merged and left standstill.

In described step c, above-mentioned extracted twice liquid can be merged to 1.35 filtrate when concentrating under reduced pressure relative density is 80 DEG C, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 80 DEG C-100 DEG C, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and packed in bag with raw material medicated powder.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot again, and in described Chinese medicine composition, medicine for external use agent type is powder, and its preparation method comprises:

First Herba Asari and Radix Notoginseng are extracted according to described portion rate, make crystallization; Component described in all the other is mixed by proportioning except dried Alumen, drop into pulverizer and be ground into fine powder, after fine powder sieves, put into acid and alkali-resistance infusion kettle, decoct 1-2 hour, filter; Filtering residue adds water and decocts 1-2 hour again, filters; Mix extracted twice liquid, carry out squeeze and filter, after separation, get filtrate, extracted twice liquid concentrate drying is become to powder, mix the crystal that distillation obtains, evener by mixing after dried Alumen pulverizing, after ultraviolet radiation for sterilizing and disinfecting, make powder.

The extraction of described Herba Asari and Radix Notoginseng, can steam distillation, supercritical fluid extraction.

For solving the problems of the technologies described above, the present invention also provides a kind of pharmaceutical dosage form of Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot, and the dosage form for oral administration of described Chinese medicine composition can be: tablet, pin powder, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation or plaster; Exterior-applied formulation can be: foot bath agent, tincture, powder, unguentum, spray, gauze agent, membrane agent or application.

For solving the problems of the technologies described above, the present invention also provides its using method that a kind of exterior-applied formulation for the treatment of QI and blood deficiency blood stasis type diabetic foot is loose powder agent to be: can first skin ulcer face first be cleaned with 3% hydrogen peroxide, wipe out slough, clean with normal saline again, periphery skin 75% alcohol disinfecting, then by loose powder agent of the present invention, be dispersed in equably on skin ulcer face, to cover and to exceed whole skin ulcer faces to surrounding normal skin, cover again 2～3 layers of sterile gauze, fix with Breathable adhesive tape, change dressings 1 day 1 time, treating 20 days is 1 course for the treatment of.

The present invention, according to patient's disease, selects corresponding prescription, and great majority are blood circulation promoting and blood stasis dispelling, the medicine of heat clearing away and internal heat reducing, and these medicines can be expanded lower limb vascular, suppress platelet aggregation, reduce blood viscosity, improve lower limb blood circulation, and diabetes are had to obvious curative effect.But should note: (1) should suitably be strengthened this disease dosage; (2) avoid damaging healthy energy, be equipped with qi-invigorating, blood-nourishing medicinal; (3) in medication, to note monitoring coagulation function and hematoblastic variation.

The present invention is Chinese medicine composition, can reach and alleviate patient's slight illness, and wound healing, reduces amputation rate, improves patients ' life quality object; The present invention adopts the Chinese crude drug of different properties, qi and blood tonifying, benefiting vital QI and blood, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting.Improve on the one hand the local blood capillary obstacle of lower limb, blood circulation promoting, comes off slough as early as possible, reaches tissue repair; Endo-medicine is effectively controlled blood glucose, regulates blood viscosity, is reduced blood pressure on the other hand; To prevent foot to infect, enhancing human body immunity function simultaneously; Oral medicinal herb and external application can improve ulcer surface microcirculation effectively, increase the groundwater increment of local organization, promote the regeneration of inflammation absorption and granulation tissue and epithelium, reach the object of ulcer surface wound healing.Adopt Chinese medicine internal and external application method treatment diabetic foot to shorten the time of ulcer healing, evident in efficacy, clinic is applied.

Detailed description of the invention

Chinese medicine ancient medicine has many discussions and record to diabetes complicated carbuncle.Diabetic foot belongs to the accompanied symptoms " necrosis " of traditional Chinese medical science diabetes.About having many discussions in diabetes patient concurrent " necrosis " traditional Chinese medical science ancient books.Tang's Sun Simiao " prescriptions worth thousand gold " has the record of " people who quenches one's thirst, heals and do not heal, and often ponders over and has large carbuncle, and the people that whichever is quenched one's thirst must finally, die in large carbuncle also so guard against in DAGU internode generation carbuncle ".Sui Dynasty's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases " is recorded, and diabetes has eight times, comprising " carbuncle ".The Wang Tao Tang Dynasty " medical secrets of official " records, " diabetes ... multiple carbuncle ".Yuan Dynasty Zhu Rui chapter " precious mirror of hygiene " is recorded " person of quenching one's thirst foot knee joint is sent out malignant boil, to stubbornly refuse rescue " ...Unit's Zhu Zhenheng " danxi's experiential therapy " has been recorded the clinical symptoms of diabetes necrosiss in detail, point out " necrosis is born between toes; ... nascent as foxtail millet Rubus pectinellus is a bit; color of the leather is secretly purple; just as boiling Fructus Jujubae; black gas spreads, rot to prolong out ... sprinkle fire combustion just as soup " traditional Chinese medical science roughly thinks there are three aspects to the pathogenic inducement of diabetic foot: the heresy of (1) impression cold.Diabetics foot is subject to the heresy of cold, or paddles and drop down river or sense is cold or sleep in the open in antiperspirant Water Exit or field, snow sky etc., all can cause cold-evil to attack outward, coagulation of QI-blood, passages through which vital energy circulates impatency and falling ill ...What we added up that prompting directly causes by catching a cold accounts for 7%～9% of patient's number; (2) experience burning hot heresy.Diabetics, the deficiency of YIN is this, scorchingly experiences again burning hot heresy for mark, and the moon is more empty, scorchingly more contains, and burning hot heresy is gathered in part, corrosion flesh and blood and be pus of carbuncle.We add up prompting and account for 13%～15% of patient's number by the burning hot heresy of impression as what burn and scald caused; (3) external injury.External injury on the direct occurrence cause of diabetic foot in the highest flight, various external injuries (friction injury, prune accidentally, foreign object damage, callus, mosquito bite, iatrogenic injury, postoperatively do not heal) directly injure human body, cause local coagulation of QI-blood, or because of after damage, cause passages through which vital energy circulates stasis blocking, QI-blood circulation is not normal and fall ill.External injury causes patient and accounts for the more than 60% of patient's number according to statistics.

Diabetic foot exist the weakened body resistance and domination of pathogen two aspect factors, statistics accounts for more than 95%, and think its be weakened body resistance or domination of pathogen single factors due to person's less than 5%.Weakened body resistance person, comprises deficiency of both QI and YIN, the deficiency of vital energy, the deficiency of YIN, QI and blood deficiency, asthenia of both the spleen and kidney, yang deficiency, deficiency of both YIN and YANG etc. ' ".Clearly think that diabetic foot occurs on deficiency of both QI and YIN basis person maximum, account for 47%.Domination of pathogen person, includes the stasis of blood, stagnation of phlegm, damp and hot, pyretic toxicity, ecchymosis etc.Think that diabetic foot occurs to reach 83% with blood stasis relative.According to us, the observational study of diabetic foot different lesions stage clinical symptoms, tongue pulse condition and tcm syndrome is found, diabetic feet is in early days taking void as main, taking deficiency of qi and yin or yang-energy virtual loss as common, accompanies blood stasis and venation discord; Patient's syndrome performance in mid-term is complicated, if invade in exopathogen, healthy energy remains, and struggle between vital QI and pathogen shows taking the domination of pathogen as main, with dampness-heat in the liver and gallbladder, and dominance of heat in the interior, it is main in noxious dampness, accumulateing, if healthy energy virtual loss, simulataneous insufficiency and excessive; The many courses of disease of patient in late period are both of a specified duration, and consumption is hindered healthy energy, and simulataneous insufficiency and excessive is pressed from both sides the mutual resistance of the expectorant stasis of blood as main taking the hepatic and renal YIN deficiency or deficiency of spleen-YANG and kidneyYANG.Diabetic foot can occur in thanks to scorching, deficiency of both QI and YIN, each stage of deficiency in both YIN and YANG of diabetes the moon, and blood stasis is its important pathologic basis that development occurs, and multifarious external injury occupies an important position in diabetic foot morbidity.Current research prompting, diabetics is on the pathologic basis of deficiency of both QI and YIN, and the deficiency of vital energy is without trying hard to recommend blood operation, and thrombosis or obstruction sering cause the stasis of blood; Hyperactivity of fire caused by deficiency of YIN decocts body fluid, makes blood viscid, and operation does not freely cause the stasis of blood; After blood stasis forms: (1) blood loses the nutrition of histoorgan and moistens effect; (2) blood stasis, in interior, is difficult carrier gas, defends gas and loses it and normally defend the functions such as outer; (3) blood stasis hinders in part, strongly fragrant and heat-transformation, more cause deficiency of YIN leading to consumption of QI, very person becomes the poison of stagnant heat. in sunset paathogenic factor, the evil cold coagulation of cold causes the stasis of blood and increases the weight of the state of an illness, external injury can cause coagulation of QI-blood in direct effect part, and pathogenic heat, damp, malicious heresy are invaded into pyretic toxicity, diseases caused by noxions dampness, is combined to form hot and humid ecchymosis and become mutually trouble with local pathological product.It may be more than the pathogenic main mechanism of diabetic foot.But clinical research also notification portion patient does not show the syndromes such as the gas deficiency of YIN or yang deficiency, and only show as that pyretic toxicity pents up or damp and hot, the syndrome such as noxious dampness pents up, also have some patients were, do not show the existence of syndrome of blood stasis.So, to thoroughly illustrate the basic pathogenesis change law of diabetic foot, still need to do a large amount of work, particularly in conjunction with modern study achievement, chamber auxiliary examination by experiment, specify the relation between the various Microscopics of diabetic foot and tcm syndrome, make it to observe and complement each other with traditional Chinese medical science integral macroscopic syndrome, finally disclose the pathogenesis key of diabetic foot.The traditional Chinese medical science is thought: the core cause of disease of diabetic foot is the deficiency of vital energy sun cold coagulation that declines, and the deficiency of vital energy can not handsome blood, and sun declines can not be warm, and the cold coagulation blood stasis of blood is stagnant not all right, and acral necrosis of a specified duration forms necrosis.Diabetic acromelic gangrene belongs to the categories such as the traditional Chinese medical science " diabetes ", " numbness ", " necrosis ".Chinese medicine thinks that the pathogenesis of primary disease is mainly to quench one's thirst with the passing of time, deficiency of both QI and YIN, passages through which vital energy circulates stasis blocking, hematogenous blockage, acra loses supports, in addition damp invasion of lower energizer, pyretic toxicity blood stasis, form BI-syndrome involved the blood vessels, necrosis, specific as follows: stagnation of blood stasis, with the passing of time the resistance of venation numbness quenches one's thirst, because of scorching in the deficiency of YIN, cloudy liquid virtual loss, scorching inclined to one side Sheng, the bright Tianjin of heat blood, and hyperamization liquid is concentrated, blood viscous, the not smooth stasis of blood of blood is slow, or due to scorching yin-damaging and Qi consuming, make deficiency of both QI and YIN, be difficult to transport blood, blood is unable, or due to cloudy liquid virtual loss, deficiency of YIN affecting YANG, yang deficiency cold coagulation, blood vessels lose in warm, all can make hematogenous blockage, form blood stasis.Once blood stasis forms, because of blood vessels numbness resistance, hematogenous blockage cause limbs part especially acra lose and support and form BI-syndrome involved the blood vessels, necrosis.Clinical and experiment shows, diabetic gangrene patient's ubiquity stagnation of blood stasis, the pathological change of venation numbness resistance.Show as instep and posterior tibial artery and beat to weaken even and disappear, Abnormal Blood Rheology, whole blood viscosity increases, platelet aggregation ability increases, and clotting mechanism is abnormal, and fibrin increases, fibrinbioplast reduces, microcirculation disturbance, and loop ejects existing tuberosity, pipe loop is smudgy, blood flow anomalies, and broken string presents lumps, hemocyte is assembled, venous plexus expansion under vein loop and nipple, there is ecchymosis etc. in loop week, microcirculation causes abnormal change to embody the essence of traditional Chinese medical science diabetes necrosis.

Radix Astragali air making-up and spleen enlivening in endo-medicine; Chinese Angelica blood replonishing tonifying liver; Radix Astragali benefiting qi and supporting yang, can receive the effect of Yin grows while yang is generating; In side, the Radix Astragali is infections section key medicine, reuses with righting QI invigorating, makes the prosperous and short blood of gas, blood stasis dispelling and just not hindering; Chinese Angelica blood replonishing is invigorated blood circulation, promoting tissue regeneration by removing blood stasis; Dredge the meridian passage; Dispelling cold by warming the meridian; Semen Ziziphi Spinosae resolving depression is dispelled tired, and nourishing YIN and clearing away heat is to moisturize; Radix Paeoniae Alba blood circulation promoting and blood stasis dispelling; Pheretima, Eupolyphaga Seu Steleophaga disperse blood stasis and dredge collateral; Stasis-dispelling and pain-killing; Heat-clearing and toxic substances removing; The good medicine of Flos Carthami promoting the flow of QI in the collateral by warming the meridian dissipating blood stasis; Rhizoma Chuanxiong is kind descending, and being longer than promoting blood circulation to remove obstruction in the collateral again can stasis-dispelling and pain-killing, and can assign foot affected part by priming; Full side's benefiting QI and nourishing blood is with Zhi Qiben, and promoting the flow of QI in the collateral by warming the meridian, to control its mark, must answer QI and blood, and blood stasis must remove, qi and blood circulation, and muscle arteries and veins is moistened foster, therefore all diseases are from removing.The Radix Et Rhizoma Rhei heat clearing away of reducing internal heat, Poria mind tranquilizing and the heart calming, granulation promoting are put on flesh; Semen Persicae, Caulis Spatholobi, Radix Salviae Miltiorrhizae freeing vessels and nourishing heart, broken stagnated blood, tissue regeneration promoting blood, Pheretima the meridian dredging, have effect of blood circulation promoting and blood stasis dispelling.All medicines coordinates, and makes altogether QI and blood fill Sheng, and short its corruption flesh of dispelling is raw, open sore part convergence.External used medicine has blood circulation promoting and blood stasis dispelling, putrefaction removing and tissue regeneration promoting, draw out the pus put on flesh, effect of skin moistening granulation promoting.Be applicable to all suppurative wounds, slough is not de-or de-, new not survivor of meat.In side, the Pseudobulbus Bletillae (Rhizoma Bletillae) has putrefaction removing and tissue regeneration promoting, short merit more, and has blood vessel dilating, improves microcirculatory function; Gypsum Fibrosum Preparatum removing dampness sore, granulation promoting are put on flesh; Sanguis Draxonis, Myrrha, the pain relieving of Olibanum promoting blood circulation to remove blood stasis, hemostasia and promoting granulation sore, is conducive to granulation tissue growth.Endo-medicine dredge the meridian passage; Dispelling cold by warming the meridian; Stasis-dispelling and pain-killing; Heat-clearing and toxic substances removing.In external side, Ramulus Cinnamomi has blood vessel dilating, promotes diaphoresis, the antibacterial effect of easing pain; The blood circulation promoting and blood stasis dispelling such as Flos Carthami, have dense, glutinous, the state of aggregation that improve blood, and anticoagulant improves local microcirculation, make blood flow further unobstructed, improve local blood supply, oxygen supply, strengthen the recovery of Nerve conduction.

Herba Dendrobii latin name: Dendrobium.Herba Dendrobii is one of orchid of recording the earliest during China's ancient Chinese prose is offered.Just on the books in Shennong's Herbal before 2000.Its direct sum Ganoderma since thousand, Radix Ginseng, Cordyceps etc. are equally listed in top grade Chinese medicine.Its nature and flavor: sweet light micro-salty.Property belong to clear and rich, have benefit in clear, invigorating middle warmer has clearly.Function cures mainly: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.

Rhizoma Corydalis cures mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.There are analgesia, calmness, syngignoscism.. analgesic activity: prove by electricity irritation mousetail method, Rhizoma Corydalis powder has analgesic activity, and it is tired as 1/10 of opium, effect continues 2 hours.Hot plate method in mice proves, Corydaline, ugly element all have significant analgesic activity.Rabbit second thermostimulation method and electric summation stimulus method prove, iv second element 15-20mg/kg, ugly plain 10-15mg/kg or first element 30-40mg/kg all have analgesic activity.And with second element, ugly element for the strongest, first element takes second place.Rat sc second element 50mg/kg or ugly plain 40mg/kg also have the analgesia effect similar to rabbit.And the third element also has obvious analgesic activity to analgesic test such as writhing response due to mouse peritoneal injection acetic acid and electrostimulations, but compared with a little less than morphine.Rat can produce toleration to the analgesic activity of second element and ugly element, slow 1 times than morphine of the speed of generation, and and morphine between have cross tolerance; Experiment also shows that second element finds no addiction.

Radix Rehmanniae Preparata: Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese crude drug, there is the YIN nourishing of enriching blood effect, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, the disease such as pass out semen, quench one's thirst, is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.1. all cards of blood deficiency.The sweet Wen Zhirun of this product, nourishing YIN benefit essence, with hemopoietic, is the key medicine of the tonify deficiency that nourishes blood.Normal and Radix Angelicae Sinensis, the Radix Paeoniae Alba, the same use of Rhizoma Chuanxiong, treat blood deficiency and yellow complexion, dizzy, cardiopalmus, insomnia and menoxenia, metrorrhagia and metrostaxis etc., as SIWU TANG); If deficiency of heart-blood severe palpitation, can be with the sedative such as Radix Polygalae, Semen Ziziphi Spinosae with using; If the empty cold in blood of metrostaxis and hyperamization, few abdomen cold type of pain person, can with the tonifying blood and arresting bleeding such as Colla Corii Asini, Folium Artemisiae Argyi, the same use of dispelling cold by warming the meridian medicine, as Ass-hide Glue and Argyi Leaf Decoction.2. all cards of the hepatic and renal YIN deficiency.This quality is moistened into kidney, kind nourishing kidney yin, and life essence-filling, marrow-benefitting, is the key medicine of tonifying kidney-yin.Ancients call it " large tonifying five ZANG-organs is Kidney-Yin ", " mending greatly true water ".Normal be equal to use with Rhizoma Dioscoreae, Fructus Corni, treat the hepatic and renal YIN deficiency, soreness of the waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst etc., can invigorating the liver and kidney, and beneficial marrow, as LIUWEI DIHUANG WAN; Also can be equal to treatment deficiency of YIN osteopyrexia and fever, as dabuyin pill (" danxi's experiential therapy ") with the Rhizoma Anemarrhenae, Cortex Phellodendri, Carapax Et Plastrum Testudinis.This product benefiting essence-blood, black beard and hair, the compatibilities such as normal and Radix Polygoni Multiflori, Radix Achyranthis Bidentatae, Semen Cuscutae, control blood and essence asthenia early whitening of beard and hair, as Qibao Meiran Dan (" collection of prescriptions with notes "); This product vital essence replenishing and marrow benifiting, bone and muscle strengthening, also can join Carapax Et Plastrum Testudinis, Herba Cynomorii, Rhizoma Cibotii etc., treatment deficiency of the liver and kindey, and five kinds of growth retardation five kinds of flaccidity in infant, as Huqian Wan (" collection of prescriptions with notes ").In addition, Radix Rehmanniae Preparata charcoal can stop blooding, and can be used for the blood deficiency such as metrorrhagia and goes out blood disorder.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." property of medicine opinion " carries it: monarch, and sweet in the mouth, pungent, nontoxic.The main large migratory arthralgia of energy, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, under stopping, lets out.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in abdomen is vomited and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.

Rhizoma Chuanxiong is pungent, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." herbal classic " carries it: main apoplexy enters brain headache, arthralgia due to cold, and clonic spasm of the muscle emergency, gold wound, married woman's blood closes loss of fecundity." not Lu " carries it: " except cold moving in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." be the good medicine of regulating qi to disperse stagnation.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth do not fall, dead fetus in the uterus, is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood chamber, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are long-pending, or skin infection sufferings and swollen burst uneasyly, be cards of disharmony between QI and blood all, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are the thrombosis of inhibition, antiinflammatory, analgesic effect, there is the vasoconstrictive effect of eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " effect.

Caulis Spatholobi is the dry rattan of pulse family Leguminosae plant spatholobus suberectus Spatholobus suberectusDunn.Autumn, two seasons of winter gather, and remove branch and leaf, and section, dries.Property hardship, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.The good medicine of invigorating blood circulation.

Radix Salviae Miltiorrhizae hardship, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. " detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG is controlled gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, only taste Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, the stillborn fetus that falls, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.

Pheretima: Compendium of Material Medica is referred to as to have dredge the meridian passage, blood circulation promoting and blood stasis dispelling, the effect of prophylactic treatment cardiovascular and cerebrovascular disease.Pheretima salty in the mouth cold in nature.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, logical Lip river.Cure mainly height fanatical dry, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, hemiplegia etc.Pheretima provides gets liquid and has the good effect that cloperastine is breathed heavily of determining.

The Radix Astragali is taking tonify deficiency as main, can invigorating QI to consolidate the body surface resistance, and diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.For insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst and do not hold back person for a long time.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and immunologic function that can enhancing body, therefore can also be used for preventing the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly sends out, and has antiperspirant to stop." be the good medicine of promoting resistance and defence disease.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, the really gas medicine in blood, the also panacea in blood.Approximately mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Its cold in nature, salty in the mouth of Eupolyphaga Seu Steleophaga, poisonous, can enter conscience spleen three warps, there is removing blood stasis, removing mass, dredging collateral, reason wound and reunion of bone, reducing swelling and alleviating pain, stimulating milk secretion effect such as stimulate the menstrual flow, be treating blood disorders traumatology key medicine, be applicable to the diseases such as cancer abdominal mass is gathered, amenorrhea due to stagnation of blood, postnatal blood stasis stomachache, traumatic injury, swollen and rigid tongue, congenital deformity of the tongue.Adjust fat effect: Eupolyphaga Seu Steleophaga decocting liquid gavage; experimental hyperlipidemia Carnis Coturnicis japonicae plasma high density lipoprotein level-cholesterol and total cholesteric ratio (HDL-C/TC) can obviously raise; increase lecithin cholesterol acyltransferase (LCAT) activity, and have certain atherogenesis effect that delays.

Radix Achyranthis Bidentatae invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow; Ignite (blood) descending; Inducing diuresis for treating stranguria syndrome.Soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; Lump in the abdomen; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; Carbuncle malignant boil; Laryngopharynx swelling and pain.Medicine dispels the wind; Blood circulation and stasis-eliminating medicine.Radix Achyranthis Bidentatae has the hemorheology properties of change and anticoagulation, can reduce whole blood viscosity and the erythrocyte aggregation index of the high and low shear rate of rat, reduces packed cell volume, and the low shear rate whole blood viscosity of blood stasis model rat is also had to reducing effect; To blood plasma recalcification time also significant prolongation. Inokopolyose has immunological enhancement." not Lu " carries it: the middle weak breath of curing the wound, and male kidney yin disappears, and old man loses excessive, and invigorating middle warmer is absolutely continuous, fills out bone marrow, and except pain and pain along the spinal column in brain, married woman's moon water is obstructed, blood agglomeration, benefit essence, Li Yin gas, only turns white.

Semen Sinapis Albae is breathed with cough for cold-phlegm, distending pain in the chest and hypochondrium, the stagnant meridians of expectorant, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.Raw with warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.Stimulation: Semen Sinapis is containing potassium myronate, and itself has no stimulation glycoside, generates volatile oil but meet water through the effect of myrosase, and main component is allyl isosulfocyanate, has pungent acid and stimulation.Be applied to skin, have warm sensation and make it rubescent, even cause blister, pustule.Conventionally mustard flour is used except making emplastra sinapis after degrease song, as counter-stimulus, (dripping of irritant drugs is used in local skin, its effect is not limited only to agents area, and involve other positions, while producing therapeutical effect, be called irritation effect), treatment neuralgia, rheumatalgia, pleuritis and sprain etc.Before use, first use the water of tepor moistening, to strengthen the effect (boiling water suppresses the effect of myrosase) of myrosase.Applicative time is no more than 15～30 minutes, and skin sensitivity person can only apply 5～10 minutes.Mustard flour, as flavoring agent, increases salivation and amylase activity, and heart size and heart rate are reduced.Can stimulate in a small amount gastric mucosa to increase the secretion of gastric juice and pancreatic juice, sometimes can alleviate intractable singultus.Take orally and can cause vomiting rapidly in a large number, can be used for the treatment of narcoticness drug intoxication." Mingyi Bielu ": acrid in the mouth, temperature, nontoxic.Return nose.Main except kidney pathogen, sharp nine orifices, improve visual and auditory acuity, regulating the spleen and stomach.Take for a long time warming middle-JIAO, Semen Sinapis Albae again, master penetrates work and chronic infectious disease gas is sent out lack perseverance place, and ball takes it; Or smash as end, vinegar and painting, test conveniently also.

Radix Curcumae is pungent, bitter, cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine." book on Chinese herbal medicine just ": emesis blood, epistaxis; Alone married woman's cold air accumulation of blood of controlling, knot gather qi together is stagnant, and trusted subordinate has a pain.

Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.There is the function of clearing away heat and cooling blood, eliminating stasis to stop pain.Raw Radix Paeoniae Rubra is with clearing away heat and cooling blood power victory, and the present invention uses raw Radix Paeoniae Rubra exactly.The fever of the body that is used for the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases is hemorrhage, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus.Function: clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control that the stagnant amenorrhea of the stasis of blood, hernia abdominal mass gather, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.The Radix Paeoniae Rubra point excess-heat that can purify the blood, dissipating blood stasis blood is detained.This product function and Cortex Moutan are close, therefore normal and Cortex Moutan mutual reinforcement between are use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, point excess-heat that can purify the blood, can control again fever due to yin deficiency; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.

Cortex Cinnamomi extremely hot in nature, acrid in the mouth, sweet.That benefit fire is supporing yang, let the fire back to its origin, dispersing cold for relieving pain, the good medicine of promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG; Gate of vitality's fire aversion to cold and cold limbs; Soreness of the waist and knees; Impotence and seminal emission; Dysuria or frequency; The dyspnea with rapid and short breath of losing heart; The all cards of edema oliguria; Decline of the fire from the gate of life; Fire is Gui Yuan not; Floating YANG; Refusing yang; And heat in the upper and cold in the lower; Flushed complexion cold foot; Dizziness and tinnitus; Dispute is rotten broken; Spleen-kidney vacuity cold; Coldness and pain in the epigastrium; Decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain; Cold womb is infertile; Dysmenorrhea amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Carbuncle of yin nature multiple abscess; Or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus; Or do not hold back after bursting." not Lu " carries it: main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, only saliva, cough; Can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, and nothing institute is feared.

The Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, mixes after steaming and dries and be used as medicine for Radix Polygoni Multiflori Preparata with Semen sojae atricolor liquor.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, be usually used in treating scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.

Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.1. anastalsis: Pseudobulbus Bletillae (Rhizoma Bletillae) can strengthen platelet factor III activity, significantly shortens clotting time and thrombinogen formation time, suppresses plasmin enzymatic activity, and local hemorrhage is had to anastalsis; Zoopery shows, external haemostatic effect is quite good to parenchymatous organ's (liver, spleen), muscle vascular be hemorrhage etc. for Pseudobulbus Bletillae (Rhizoma Bletillae) water extraction.2. protection gastric mucosa: 1% Pseudobulbus Bletillae (Rhizoma Bletillae) decoct gavage, the rat pipe film injury that hydrochloric acid is caused has protective effect; To anesthetized dog, experimental Stomach duodenum perforation has therapeutical effect.3. antibacterial, antifungic action: the immersion of Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol has inhibitory action to staphylococcus aureus, bacillus subtilis, Bacillus tuberculosis; Water logging agent has inhibitory action to microsporon audouini; Contained 3 biphenyl classes and 2 the luxuriant and rich with fragrance compounds of two hydrogen of Pseudobulbus Bletillae (Rhizoma Bletillae) have inhibitory action to staphylococcus aureus, bacillus subtilis, Candida albicans ATCC 1057 and Trichophyton QM248.

Radix Et Rhizoma Rhei has another name called Huang Liang, fire ginseng, and skin is as Wu Pu.Ancients are with its " main lower congestion, blood closes, cold and heat, broken lump in the abdomen, prolonged fluid-retention dyspepsia, cleanses the intestines and stomach, pushes away Chen Zhixin, tonneau water paddy, relieving dyspepsia in tune, peace and the five internal organs ".Radix Et Rhizoma Rhei is used for the treatment of burn, scalds at China's long history." book on Chinese herbal medicine cover mirror " recorded: " the yin aspect of yin, coagulated the soup clearly if grind chicken into powder, can apply burn and get effect Radix Et Rhizoma Rhei bitter in the mouth, gas Great Cold."; " medicine mirror " recorded: " large yellow maturity, with controlling all fire-toxin skin ulcers, does not close up for a long time.Lid, with all malicious burn, all belongs to fire-toxin, and large yellow maturity use, can let out fire-toxin, and reducing swelling and alleviating pain." Compendium of Material Medica grass portion the 17 volume Radix Et Rhizoma Rhei cures mainly and to record that " Radix Et Rhizoma Rhei is controlled all burn down."; Theory of Chinese medical science thinks that burn and scald is that fire-toxin is trouble, local coagulation of QI-blood, and meridians block, and putrefaction of blood and muscle forms, and Radix Et Rhizoma Rhei has the pathogenic fire purging of capturing, heat clearing away treating narcotic addiction, the key medicine that removing heat from blood clots absorbing is treatment burn, scald.Modern medicine also prove Radix Et Rhizoma Rhei have invigorate blood circulation, hemostasis, antibacterial, eliminate endotoxin, improve immunity of organisms, reduce the effects such as body temperature, analgesia.Radix Et Rhizoma Rhei contains anthraquinone, anthraquinone derivatives is stronger to staphylococcus, streptococcus antibacterial action; Tannin contained in Radix Et Rhizoma Rhei has good astriction to wound surface, can promote wound face healing.

Radix Sanguisorbae property of medicine picric acid; Cold; Nontoxic, return liver; Lung; Kidney; Large intestine channel, effect cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Effect classification hemorrhage; Blood-cooling hemostatic.Cure mainly haematemesis, spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting." detailed outline ": Radix Sanguisorbae, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat, control defecation blood disorder.Hemostasis, gets and cuts off sheet and fry use, and its tip can promoting the circulation of blood, can not know.Yang Shiying cloud: all skin ulcer pain persons add Radix Sanguisorbae, and the person of itching adds Radix Scutellariae.

Radix Sanguisorbae preparata: Radix Sanguisorbae is dried and is ground into superfine powder, sieve; Another boil with Oleum Sesami (or vegetable oil), then elm powder intensively rapidly, stirs and makes into pasty state, is contained in sterile pot interior for subsequent use.Mass is directly applied to wound surface by used time, can form very soon 1 thick layer medicine crust, can play prevention and infection control, and eliminate pain promotes the effects such as wound surface heals rapidly.Generally be applicable to one, second degree burn, scalded patient.Radix Sanguisorbae contains a large amount of tannins, has stronger convergence and pressor effect, can reduce the permeability of blood vessel, reduces inflammatory exudation, also has obvious bactericidal action simultaneously, can resist charrin's disease.Also can adopt Radix Sanguisorbae ethanol liquid (Radix Sanguisorbae is cleaned and dries, and grinds coarser powder 70～75% ethanol percolation and extracts clear liquids, boils to liquid level and occurs thin film, cooling for subsequent use) to be coated with burn wound, every day 2～3 times, not wrap up.Coating number of times forms dry crusts and does not occur that be full of cracks is as degree taking wound surface.To the wound surface having polluted debridement treatment in advance.By one, the observation of second degree burn patient 40 examples; prove that this method is to superficial burns, special centering small size, to pollute lighter burn effect better, generally on wound surface, can form 1 layer of brown protecting film through 12～24 hours; this oozes out preventing germ contamination, minimizing wound surface, all has good impact.

Cortex Phellodendri heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Cortex Phellodendri nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency." Chinese Pharmacopoeia " carries the power of Cortex Phellodendri heat clearing and damp drying, similar to Radix Scutellariae, Rhizoma Coptidis, but damp and hot as good taking except the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.

The Myrrha blood blood stasis removing that falls apart, subduing swelling and relieving pain.Control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Hardship, pungent, flat.1. " property of medicine opinion ": " bitter in the mouth is pungent." 2. " Haiyao Bencao, Oversea Materia Medica ": " bitter in the mouth is pungent, and temperature is nontoxic." 3. " Kaibao Bencao ": " and bitter in the mouth, flat, nontoxic." enter liver, spleen, the heart, kidney channel.1. " Bencao Jingshu ": " enter meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine is newly organized ": " enter spleen, kidney two warps." 3. " book on Chinese herbal medicine is looked for the truth ": " enter the heart, liver." join Olibanum, promoting blood circulation to remove blood stasis, circulation of qi promoting relaxing muscles and tendons; Wear Squama Manis, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.Match exhausts, promoting blood circulation to remove blood stasis, pain relieving.Join Realgar, detumescence and promoting granulation, dampness removing toxic substances.

Olibanum is arduous, temperature.Regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge." not Lu ": treat edema due to wind pathogen poison swollen, remove bad odor.Treat the urticaria poison of itching.Supplement to the Herbal: treat deaf, apoplexy locked mouth, married woman's vim and vigour, can send out wine, manage air-cooledly, stop large intestine and let out Bleach, treat all skin ulcers and make internal diabetes.Control to fall and flutter injured.

Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Tradition thinks that Radix Clematidis has wind-damp dispelling, the meridian dredging, the bone that disappears three large effects of choking, because its property is walked to alter, pharmacology confirms that it removes esophagus in addition, bronchus, ureter, stomach and biliary tract etc. are located the effect of smooth muscle spasm, and there is a stronger anti-inflammatory analgetic effect, hypoglycemic activity Radix Clematidis preserved material to normal rat have the assimilation of remarkable enhancing glucose effect (give rat with a large amount of glucoses after, glucose in urine test is still negative), therefore may there is hypoglycemic activity. in vitro, water logging agent has inhibitory action to dermatophytes. and water logging agent also has inhibitory action to microsporon audouini, decoct has inhibitory action to staphylococcus aureus, shigella. and decoct lumbar injection can slightly improve the mice threshold of pain, points out it to have analgesic activity. and decoct has inhibitory action to plasmodium. and alcohol extract has induced labor effect to mice midtrimester of pregnancy.

Herba Asari cures mainly: dispels the wind, and cold expelling, row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.Warm in nature, acrid in the mouth, function dispelling cold by warming the meridian, dissipating fluid-retention, wind-expelling pain-stopping, cure mainly the diseases such as headche due to wind-cold, phlegm retention cough with asthma, rheumatic arthralgia, toothache, nasal sinusitis.Antiinflammatory, immunosuppressant and antiallergic action Herba Asari volatile oil gavage or inject all obvious antiinflammatory action.As Herba Asari has obvious inhibitory action to the rat arthroncus due to proinflammatory agent carrageenin, yeast, Ovum Gallus domesticus album, formaldehyde etc., and can resist Oleum Tiglii induced mice auricle edema, the rat skin edema that inhibition antiserum causes, the capillary permeability being caused by histamine increase and inhibition plastic hoop and cotton balls granulation hyperplasia.To the rat of adrenalectomy, still have antiinflammatory action.

The sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Rare Chinese medicine, raw with can hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, there is good hemostasia effect, significant hemopoietic function; Can tighten and improve Coronary microcirculation, Radix Notoginseng is used as medicine with a long history, acts on being peculiarly considered as the treasured in medicine by ancient Chinese medicine doctor, therefore there is the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) "." taste is micro-sweet and bitter, quite seemingly the taste of Radix Ginseng for Radix Notoginseng." " all canes are flutterred trauma, and the dripping person of blood stasis, chews stopping of rotten net for catching birds or fish immediately, and bruise person dissipate.If while being subject to cane, first take one, two money, the not centre of punch of blood, should take it after cane especially, and puerperal, clothes were also good.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of the cloudy blood system of fainting, therefore can control all disorders of blood "." book on Chinese herbal medicine is looked for the truth " recorded: " Radix Notoginseng, common people only know function hemostasis and pain-relieving.Hardly realize that pain aches work because of blood stasis, blood is because only applying loose blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient, can be in its blood stasis of blood systemization.”

Dried Alumen expectorant, dampness, antidiarrheal, hemostasis, removing toxic substances, parasite killing.Control epilepsy, sore throat, remorse saliva is stopped up very, hepatitis, jaundice, general edema with yellowish skin, Stomach duodenum ulcer, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies, water, fire, insect bite." detailed outline ": " tell lower sputum drink phosphorus, dampness removing toxic substances, chases after saliva, hemostasis analgesic therapy, meat is disliked in erosion, and raw good meat, controls carbuncle furuncle swollen, malignant boil, epilepsy, subcutaneous ulcer disease, relieving bowels, all diseases of ability to speak eyes, brave dog snakes and scorpions hundred insect bites."

Fructus Cnidii is pungent, bitter, temperature; Slightly poisonous.Return kidney channel.Cure mainly warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Senile vaginitis is gynecological external use good medicine." Bencao Jingshu " carries: Fructus Cnidii, and bitter in the mouth is flat; " not Lu " be pungent sweet nontoxic; Modern its abnormal smells from the patient in detail, when the warm-dryness syndrome of must holding concurrently, sun also.Therefore swell and ache in housewife people's the moon, man's impotence pruritus due to damp pathogen, except stagnated QI, sharp joint, malignant boil." not Lu " warming the middle warmer and descending qi, makes married woman's Zifu heat, and man is cloudy strong, has made us son.Lid can dehumidify with tongue, and temperature can cold expelling, pungently can moisten kidney, sweet can strengthening the spleen, therefore can remove all deficiency and coldness of married woman man disease of viscera connecting with this channel that wets.Cold-damp was both removed, and disease is gone, performance Yiyang, thus disease, and have tonification also.

Rhizoma Drynariae hardship, temperature.Return kidney, Liver Channel.Function the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo." Japan hanako materia medica " carries it: control malignant boil, lose rotten meat, parasite killing.That surgery is for removing the good medicine of skin toxin.

The manufacturing process of pill of the present invention is: get Rhizoma Corydalis 1000g, Radix Rehmanniae Preparata 1200g, Radix Angelicae Sinensis 1300g, Radix Astragali 1400g, Radix Achyranthis Bidentatae 1300g, Radix Salviae Miltiorrhizae 1500g, Radix Polygoni Multiflori Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1400g, Poria 1300g, Radix Curcumae 1500g, Flos Carthami 1300g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1100g, Pheretima 1400g, Herba Dendrobii 1200g, Eupolyphaga Seu Steleophaga 1300g, Cortex Cinnamomi 1200g, Semen Sinapis Albae 1100g, Radix Paeoniae Rubra 1200g, first by 75% soak with ethanol 12-24 hour for raw medicinal material, heat is extracted three times, filter, filtrate merges and reclaims ethanol, be condensed into thick paste, 70 DEG C of following drying under reduced pressure, be ground into fine powder, ethanol refined medicinal residues, decocted with water 1 time, and the time is 30 minutes-1 hour, and decocting liquid filters, and filtrate is condensed into thick paste, dry, pulverize into fine powder, the fine powder obtaining of twice is mixed, be twisted into pill.

The manufacturing process of capsule of the present invention is: raw medicinal material Rhizoma Corydalis 1400g, Radix Rehmanniae Preparata 1500g, Radix Angelicae Sinensis 1300g, Radix Astragali 1400g, Radix Achyranthis Bidentatae 1300g, Radix Salviae Miltiorrhizae 1500g, Radix Polygoni Multiflori Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1400g, Poria 1300g, Radix Curcumae 1500g, Flos Carthami 1300g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1100g, Pheretima 1200g, Herba Dendrobii 1200g, Eupolyphaga Seu Steleophaga 1200g, Cortex Cinnamomi 1100g, Semen Sinapis Albae 1500g, Radix Paeoniae Rubra 1300g, raw medicinal material is pulverized with pulverizer by described ratio of weight and number mixing, then cross 120 mesh sieves, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, it is for subsequent use that collection obtains fine powder by the fine powder of 120 mesh sieves, can not drop into multi-function extractor by the coarse powder of 120 mesh sieves again and extract twice, and add for the first time 8-10 and doubly measure ethanol extraction 1-2 hour, and add for the second time 4-8 and doubly measure ethanol extraction 1-2 hour, merge extracted twice liquid, filter to get filtrate, heating is concentrated into pasty state, puts into after 80 DEG C of oven dry of baking oven coolingly, grinds to form fine powder, the fine powder obtaining of twice is mixed, after ultraviolet disinfection, incapsulate.

Method for preparing tablet thereof of the present invention: get raw medicinal material Rhizoma Corydalis 1300g, Radix Rehmanniae Preparata 1400g, Radix Angelicae Sinensis 1500g, Radix Astragali 1400g, Radix Achyranthis Bidentatae 1300g, Radix Salviae Miltiorrhizae 1500g, Radix Polygoni Multiflori Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1400g, Poria 1300g, Radix Curcumae 1500g, Flos Carthami 1200g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1100g, Pheretima 1300g, Herba Dendrobii 1100g, Eupolyphaga Seu Steleophaga 1200g, Cortex Cinnamomi 1100g, Semen Sinapis Albae 1100g, Radix Paeoniae Rubra 1500g, put into into multi-function extractor and extract twice by described ratio of weight and number, add for the first time 8-10 and doubly measure ethanol extraction 1-2 hour, add for the second time 4-8 and doubly measure ethanol extraction 1-2 hour, merge extracted twice liquid, filter to get filtrate, heating is concentrated into pasty state, puts into after 80 DEG C of oven dry of baking oven coolingly, grinds to form fine powder, the medicinal residues that ethanol was refined are put into 5-10 times of water gaging heating extraction twice, each 1-2 hour, merge extractive liquid,, filters, concentrated, 80-160 order filters, the 6000-10000 rev/min of supernatant after centrifugal, is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.35 extractum when ultrafiltrate concentrating under reduced pressure relative density is 60 DEG C, heating is concentrated dries, and becomes fine powder, the fine powder of twice is mixed, and ultraviolet disinfection adds starch tabletting.

The preparation method of granule of the present invention: a. is by described crude drug raw medicinal material Rhizoma Corydalis 1200g, Radix Rehmanniae Preparata 1500g, Radix Angelicae Sinensis 1500g, Radix Astragali 1400g, Radix Achyranthis Bidentatae 1300g, Radix Salviae Miltiorrhizae 1500g, Radix Polygoni Multiflori Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1400g, Poria 1400g, Radix Curcumae 1200g, Flos Carthami 1500g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1100g, Pheretima 1300g, Herba Dendrobii 1100g, Eupolyphaga Seu Steleophaga 1300g, Cortex Cinnamomi 1500g, Semen Sinapis Albae 1400g, Radix Paeoniae Rubra 1200g puts into after pulverizer is pulverized and crosses 100-120 order dusting cover, the fine powder amount that enable pass is crossed sieve aperture is reaching 30%-40%, collect by the raw material fine powder of sieve aperture for subsequent use.Put into pulverizer grinding and sieving; Particulate matter remaining after sieving is put into 10 times of amount 75% ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged and left standstill; Above-mentioned extracted twice liquid is merged, and 1.35 filtrate when concentrating under reduced pressure relative density is 80 DEG C, reclaims ethanol, and gained filtrate is adjusted to proportion to 1.06, pass into spray dryer spray dry, the compressed air pressure of spray dryer shower nozzle be 4kg/m ², hothouse hot stream temperature is 80 DEG C-100 DEG C, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and packed in bag with raw material medicated powder.

In Chinese medicine composition, medicine for external use agent type is powder, and its preparation method comprises: first by Herba Asari 1800g and Radix Notoginseng 2000g water steam extraction method, make crystallization according to described portion rate; By component Radix Clematidis 1900g described in all the other, Olibanum 2300g, Myrrha 2100g, Radix Et Rhizoma Rhei 1800g, Cortex Phellodendri 1700g, Rhizoma Smilacis Glabrae 1900g, Radix Sanguisorbae preparata 2100g, Flos Carthami 1700g, Fructus Cnidii 1600g, Pseudobulbus Bletillae (Rhizoma Bletillae) 2100g, Rhizoma Drynariae 2100g mixes by proportioning, drops into pulverizer and is ground into fine powder, after fine powder sieves, puts into acid and alkali-resistance infusion kettle, decoct 1-2 hour, filter; Filtering residue adds water and decocts 1-2 hour again, filters; Mix extracted twice liquid, carry out squeeze and filter, after separation, get filtrate, extracted twice liquid concentrate drying is become to powder, mix the crystal that distillation obtains, evener by mixing after dried Alumen 2100g pulverizing, after ultraviolet radiation for sterilizing and disinfecting, make powder.

The preparation method of external gauze of the present invention agent: by described crude drug Radix Clematidis 2100g, Olibanum 2300g, Myrrha 2100g, Radix Et Rhizoma Rhei 1800g, Cortex Phellodendri 1700g, Rhizoma Smilacis Glabrae 1900g, Radix Sanguisorbae preparata 2100g, Flos Carthami 1700g, Fructus Cnidii 1900g, Pseudobulbus Bletillae (Rhizoma Bletillae) 2500g, Rhizoma Drynariae 2000g, Radix Notoginseng 2100g, Herba Asari 2300g, dried Alumen 2400g grinds to the powder altogether, crosses l20 mesh sieve, and coarse powder adds ethanol extraction once, be condensed into powder, two kinds of powder mixing add 70% vaseline tune and are all applied to aseptic dry sliver, put in container, for subsequent use after high pressure steam sterilization sterilization; Wound surface is changed dressings: through thoroughly remove the slough of ulcer wound surface with surgical method after, a l～2 of the present invention layer sliver spread on to wound surface, do not contact normal skin, external use sterile gauze piece covers.

Using method is: first skin ulcer face is first cleaned with 3% hydrogen peroxide, wipe out slough, clean with normal saline, periphery skin 75% alcohol disinfecting, then mixes the present invention to break into fine powder again, be dispersed in equably on skin ulcer face, to cover and to exceed whole skin ulcer faces to surrounding normal skin, then cover 2～3 layers of sterile gauze, fix with Breathable adhesive tape, change dressings 1 day 1 time, treating 20 days is 1 course for the treatment of.

The dosage form of external is that the preparation method of ointment comprises: by described crude drug Radix Clematidis 2100g, Olibanum 2300g, Myrrha 2100g, Radix Et Rhizoma Rhei 1800g, Cortex Phellodendri 1700g, Rhizoma Smilacis Glabrae 1900g, Radix Sanguisorbae preparata 2100g, Flos Carthami 1700g, Fructus Cnidii 1900g, Pseudobulbus Bletillae (Rhizoma Bletillae) 2500g, Rhizoma Drynariae 2000g, Radix Notoginseng 2100g, Herba Asari 2300g, adds soak with ethanol 1-2 hour, and heating is boiled 30～40 minutes, filter, filtrate is for subsequent use; Filtering residue adds ethanol and heats for the second time, boils 30～40 minutes, filters, and filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled 40～50 minutes is for the third time filtered; Merge the extracting solution of three times, be concentrated into relative density and be 1.08 concentrated solution; Filter, leave standstill 24 hours, after remove supernatant, obtain concentrated medicament; Dried Alumen 2500g is broken into fine powder, drop in concentrated medicament, mediation 70%-80% vaseline, tinning.

The experiment of endo-medicine pharmacology pharmacodynamic:

1 materials and methods

1.1 experiment material

1.1.1 laboratory animal: 90 male SD rats, clean level, 3 monthly ages, weight 200～250g, by Shandong, medical college laboratory animal raising chamber provides, and the animal quality certification number moves No. 0222222nd, word for curing.

1.1.2 Experimental agents decoction of the present invention: Fang Yong: Rhizoma Corydalis 10g, Radix Rehmanniae Preparata 15g, Radix Angelicae Sinensis 12g, Radix Astragali 10g, Radix Achyranthis Bidentatae 11g, Radix Salviae Miltiorrhizae 12g, Radix Polygoni Multiflori Preparata 11g, Rhizoma Atractylodis Macrocephalae 15g, Poria 13g, Radix Curcumae 10g, Flos Carthami 12g, Rhizoma Chuanxiong 11g, Caulis Spatholobi 10g, Pheretima 11g, Herba Dendrobii 12g, Eupolyphaga Seu Steleophaga 11g, Cortex Cinnamomi 13g, Semen Sinapis Albae 10g, Radix Paeoniae Rubra 11g.Decoction of four noble drugs (" formulary of peaceful benevolent dispensary ") is made up of Radix Codonopsis 9g, Rhizoma Atractylodis Macrocephalae 9g, Poria 9g, Radix Glycyrrhizae 6g, and being evaporated to concentration is 0.36g/ml, and rat dosage is crude drug 2.90g/ (kgd).SIWU TANG (" formulary of peaceful benevolent dispensary ") is made up of Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 9g, Radix Paeoniae Alba 9g, Rhizoma Chuanxiong 6g, and being evaporated to concentration is 0.40g/ml, and rat dosage is crude drug 3.17g/ (kgd).BAZHEN TANG (" roman class is wanted ") is made up of Radix Codonopsis 9g, Rhizoma Atractylodis Macrocephalae 9g, Poria 9g, Radix Glycyrrhizae 6g, Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 9g, Radix Paeoniae Alba 9g, Rhizoma Chuanxiong 6g, being evaporated to concentration is 0.76g/ml, and rat dosage is crude drug 6.07g/ (kgd).

Above Chinese medicine is pressed the preparation of water decoction-alcohol sedimentation technique by the Drug Manufacturing Room of Hospital Attached to Shandong Chinese Medical Univ., and 4 DEG C of Refrigerator stores are for subsequent use.

1.1.3 main experiment reagent immunohistochemistry streptomycete avidin 2 peroxidase connection methods (st reptavidin2biotinperoxidase met hod, SP) test kit, purchased from Zymed company of the U.S.; Instant EnVision reagent, purchased from Dako company of Denmark; VEGF (vascular endot helial growt hfactor, VEGF) primary antibodie (the anti-Mus of rabbit, respectively dilution in 1: 100,1: 50), purchased from Santa Cruz company of the U.S.; Biotin labeled goat anti-rabbit immunoglobulin G (immunoglobulin G, IgG), purchased from German Vector company; Horseradish peroxidase (horseradishperoxidase, HRP) labelling goat anti-mouse antibody, purchased from Beijing Zhong Shan company; Injection hydrocortisone sodium succinate (50mg/ props up), purchased from Tianjin Biochemical Pharmaceutical Factory.

1.1.4 main experimental apparatus IMS cytological image analyses system and medical image analysis software, purchased from Shanghai Shen Teng Information Technology Co., Ltd; Video camera (model: MV2CP410), purchased from Panasonic company; Optical microscope, purchased from Olymp us company; B H2 digital camera, purchased from Nikon company.

1.2 experimental technique

1.2.1 the foundation of chronic wound rat model

Rat is conventional to be raised after 1 week, ketalar (100mg/kg) intraperitoneal injection of anesthesia, molding bay (lumbar vertebra center is on the upper side) cropping, with the plastic bottle closure of diameter 20mm at molding bay labelling modeling area, under aseptic condition, make two dark wound surface that reach fascia along vertebra direction with surgical method, set up the open wound model of full thickness dermal.Except Normal group, intramuscular injection hydrocortisone acetate (80mg/kg weight) at once after rat modeling, makes refractory wound surface model.Wound surface is added a cover two-layer sterilization dry gauze, fixes with adhesive plaster " rich " font.Every the continuous 4d hindlimb muscle injection of rat penicillin 400,000 U after modeling, with prevention infection.

1.2.2 laboratory animal grouping divides 2 batches to test with 90 rats of medication.The 1st batch of 40 rats are mainly used in observing the impact of medicine on wound healing time.40 rats first extract 8, and for Normal group, wound surface manufacture method is the same, and all the other 32 rats are set up model of chronic wound.After Cheng Mo, be divided at random again model group (8), decoction of four noble drugs group (8), SIWU TANG group (8), BAZHEN TANG group (8).The 2nd batch of 50 rats are mainly used in inquiring into the mechanism of the short wound healing of medicine.50 rats first extract 10, and for Normal group, wound surface manufacture method is the same, and all the other 40 rats are set up model of chronic wound.After Cheng Mo, be divided at random again model group (10), decoction of four noble drugs group (10), SIWU TANG group (10), BAZHEN TANG group (10).Each group starts administration in the 2nd day after modeling, before changing dressings, all cleans wound surface with 1/5000 furacilin solution.Normal group and model group external application monolayer normal saline gauze, normal saline gavage, 1 time/d; Decoction of four noble drugs group, SIWU TANG group and BAZHEN TANG group external application monolayer normal saline gauze, give corresponding Chinese medicine gavage, and 1 time/d, continuous use 7d.After drug withdrawal the 2nd day, respectively animal Patients Under Ketamine Anesthesia is put to death, get local woanded surface new granulation tissue and detect.1.2.3 the observation of wound healing time is observed 40 rats and is played the complete epithelization required time of wound surface from topical agent.

And the detection of microvessel count 1.2.4VEGF

1.2.4.1 Use immunohistochemistrySP SP detects vegf expression

Get each group of rat wound surface new granulation tissue, after normal saline cleans, 10% formalin is fixed.Choose at random 8 samples for every group, by the fixing conventional dehydration respectively of each granulation tissue specimen, waxdip, embedding, serial section.Get 4 μ m paraffin sections, the conventional dewaxing of dimethylbenzene, gradient alcohol dehydration, PBS washing, 3min × 3 time; 3%H2O2 room temperature 20min, PBS washing, 3min × 3 time; To cut into slices and immerse in 0.01mol/Lp H 6.0 citrate buffers, antigen retrieval is carried out in microwave oven III shelves (98 DEG C) 10min × 2 time, natural cooling at room temperature after taking-up; Drip 10% normal serum sealing endogenous heterogenetic antigen, room temperature 30min; Drip VEGF primary antibodie (being respectively above-mentioned antibody and corresponding antibodies dilution factor), 4 DEG C of refrigerator overnight; PBS washing, 3min × 3 time, drip 200,37 DEG C of 30min of biotinylation goat anti-rabbit igg 1 ︰, PBS washing, 3min × 3 time; 20037 DEG C of 30min of St reptavidin2HRP 1 ︰, PBS washing, 3min × 3 time, the 0.05%DAB+0.03%H2O2 8～12min that develops the color, flowing water is washed; Haematoxylin lining dyes, and flowing water is washed; Dry up conventional resin mounting.

Detect and occur that with endochylema brown color or brown granular person are judged to be positive cell, replace primary antibodie as negative control using PBS buffer.

1.2.4.2 image analytical method is analyzed vegf expression amount and microvessel count

Adopt MV2CP410 video camera, IMS cytological image analyses system, by microscope, image pick-up card, digital camera or ccd video camera capturing digital image, BMP (bitmap) file format that digital picture is standard; Under 100 times of optical microscopes, first click two points on the micro-chi of image, then by its actual micron number input computer, computer automatically calculate store after scale factor for subsequent use; Eliminate the hyacinthine background in SABC image, select negative region, after processing, represent by blueness; Select brown color or sepia positive region, after processing, represent by redness; Measure positive region area and positive ratio and optical density value in image, 3 visuals field are chosen in every section at random, obtain the meansigma methods in 3 visuals field, calculate vegf expression level.Every paraffin section, chooses 3 visuals field in granulation tissue region at random, obtains the meansigma methods in 3 visuals field, counts microvascular number (microvessel count, MVC).

1.3 statistical method

Adopt SPSS 11.5 softwares to carry out data analysis, continuous data represents with x ± s, and whether carry out t inspection or multiple sample one factor analysis of variance (q inspection) comparison group difference has statistical significance.

2 results

2.1 impacts of benefiting vital QI and blood prescription on chronic wound healing time

Model group wound healing time compared with normal matched group obviously extends (P<0.01); With model group comparison, decoction of four noble drugs group, BAZHEN TANG group and SIWU TANG group wound healing time obviously shorten (P<0.01, P<0.05); Decoction of four noble drugs group wound healing time and Normal group comparing difference not statistically significant (P>0.05), SIWU TANG group and BAZHEN TANG group wound healing time are obviously longer than Normal group (P<0.05); With the comparison of decoction of four noble drugs group, SIWU TANG group and BAZHEN TANG group wound healing time extend (P<0.05); SIWU TANG group and the comparison of BAZHEN TANG group wound healing time, difference not statistically significant (P>0.05).In table 1.

The comparison of the each group of table 1 wound healing time

P<0.05,﹡﹡P<0.01,△P<0.05,△△P<0.01,;▲P<0.05,

2.2 impacts of benefiting vital QI and blood prescription on chronic wound granulation tissue vegf expression

The expression of model group VEGF is starkly lower than Normal group (P<0.01); Decoction of four noble drugs group, SIWU TANG group and BAZHEN TANG group vegf expression be apparently higher than model group (P<0.01, P<0.05), but all lower than Normal group (P<0.01).SIWU TANG group and BAZHEN TANG group vegf expression are lower than decoction of four noble drugs group (P<0.05).SIWU TANG group and the comparison of BAZHEN TANG group, vegf expression difference not statistically significant (P>0.05).In table 2.

2.3 impacts of benefiting vital QI and blood prescription on chronic wound granulation tissue MVC

Model group MVC is starkly lower than Normal group (P<0.01); Each treatment group MVC is apparently higher than model control group (P<0.01), but all lower than Normal group (P<0.01).SIWU TANG group and BAZHEN TANG group MVC are all starkly lower than decoction of four noble drugs group (P<0.01).SIWU TANG group MVC and the comparison of BAZHEN TANG group, difference not statistically significant (P>0.05).In table 2.

Table 2 is respectively formed face granulation tissue vegf expression and MVC

P<0.05,﹡﹡P<0.01,;△P<0.05,△△P<0.01,;▲P<0.05,▲▲P<0.01.

External used medicine pharmacodynamic experiment

Its impact that rat refractory wound surface is healed of this laboratory observation.

1 materials and methods

1.1 animals: 40 of clean level SD rats, male, weight 200-250g, average (220.32 ± 10.10) g (being provided by biology department of Shandong University breeding center).

1.2 medicines: vaseline, necrosis removing and granulation promoting plaster, external pulvis of the present invention.

1.3 reagent and instrument: ketaject injection (every 011g/2mL, Hengrui Medicine Co., Ltd., Jiangsu Prov. produces, lot number: KH051001); Hydrocortisone sodium succinate (every 50mg/2mL, Tianjin Biochemical Pharmaceutical Factory produces, lot number: 20010419,20060104); Benzylpenicillin sodium for injection (800,000 U/ prop up, and Huabei Pharmaceutic Co., Ltd produces, lot number: Y0511222).Electrocardiograph paper (specification 50mm × 30m, Shanghai three or five company limiteies of paper plant produce).

1.4 modeling methods: full thickness dermal method is made animal body surface Ulcer Models.Rat is divided into 5 groups at random: general wound surface group, model control group, vaseline group, necrosis removing and granulation promoting plaster group, unguentum group of the present invention, 8 every group.After rats by intraperitoneal injection ketalar (100mg/kg body weight) anesthesia, molding bay (lumbar vertebra center is on the upper side) is shaved hair, with diameter 2cm plastic bottle closure at molding bay labelling modeling area, benzalkonium bromide tincture cotton balls skin degerming, cut off subcutaneous tissue to muscular fasciae along mark line, hemostasis, antiseptic gauze dressing covers wound, forms the open wound model of rat full thickness dermal (general wound surface).Except general wound surface group, remaining 4 groups of intramuscular injection hydrocortisone sodium succinates (8mg/100g body weight) at once after modeling, make refractory wound surface model, inject continuously 5 days.Operation rose the same day, every group of equal intramuscular injection penicillin sodium salt (4000U/ is only), for three days on end, in case infect.

1.5 medication

Each group starts to change dressings in modeling next day, and every day 1 time, before changing dressings, all with 1/5000 nitrofural clean wound, general wound surface group and model control group all cover with normal saline gauze; Use respectively vaseline, external pulvis of the present invention for all the other each group, necrosis removing and granulation promoting plaster spreads on wound surface, and external sterile gauze covers, and medical proof fabric is fixed, and changes dressings until all wound surface all heal.

1.6 observation index

1.6.1 Wound healing rate: after modeling the 5th, 7,10 days, use hyaline membrane flap coverage, mark stroke film, then hyaline membrane is covered and on electrocardiograph paper, calculates wound surface area.Calculate Wound healing rate by following formula: healing rate=(original wound surface area-wound surface area does not heal)/original wound surface area × 100%.

1.6.2 wound healing time: record plays the complete epithelization required time of wound surface from topical agent.

1.7 statistical method

Adopt SPSS 11.0 softwares to carry out data analysis.Continuous data represents by mean ± standard deviation, carries out relatively group difference of multiple sample one factor analysis of variance.

2 results

2.1 impacts on Wound healing rate

The 5th day, the 7th day, the 10th day model control group Wound healing rate, all lower than general wound surface group (P<0.05), shows modeling success.The 5th day, each intervention group Wound healing rate was compared no significant difference (P>0.05) with model control group; The 7th day, vaseline group, necrosis removing and granulation promoting plaster group healing rate were all higher than model control group (P<0.05); The 10th day, powder group healing rate of the present invention was apparently higher than vaseline group, necrosis removing and granulation promoting plaster group (P<0.01).In table 1.

The comparison of the each group of table 1 different time points Wound healing rate (%, ^-x ± s)

With relatively ， ﹡ P<0.05 of general wound surface group; With model control group comparison, △ P<0.05, △ △ P<0.01.

2.2 impacts on wound healing time

Model control group wound healing time compared with normal wound surface group obviously extends (P<0.01); With model control group comparison, powder group healing time of the present invention shortens (P<0.01).In table 2.

The comparison of the each group of table 2 wound healing time (d, ^-x ± s)

With relatively ， ﹡ ﹡ P<0.01 of general wound surface group; With model control group comparison, △ △ P<0.01.

Clinical pharmacodynamics:

1.1 clinical datas are chosen my institute endocrine patient 40 examples of being in hospital May 1 year March in 2007, are divided at random two groups.Treatment group 20 examples, male's 13 examples, women's 7 examples; Year mean age (62.37 ± 9.13); Average 8.4 years of diabetic duration; The average 28.5d of the diabetic foot course of disease; Wound surface average area 2.54cmX 3.34cm; Fasting glucose (12.22 ± 6.41) mmol/L; Glycolated hemoglobin (11.004-2.25) %; Body Mass Index (22.76 ± 3.12).Matched group 20 examples, male's 12 examples, women's 8 examples, year mean age (64.22 ± 6.21); Diabetes average course of disease 11.1; The average 27.3d of the diabetic foot course of disease; Wound surface average area 2.75cm × 3.24cm; Fasting glucose (11.2 ± 6.41) mmo1/L; Glycolated hemoglobin (8.84 ± 2.24) %; Body Mass Index (21.76 ± 2.61).Wagner Grading treatment group is 1 grade of 7 example, 2 grade of 8 example, 3 grade of 5 example; Matched group is 1 grade of 5 example, 2 grades of l0 examples, 3 grade of 5 example.Two groups of data difference not statistically significants (P>0.05), have comparability.

1.2 diagnostic criteria Western medicine diagnoses are with reference to the diagnostic criteria of diabetic foot cooperative groups, and carry out classification by Wagner grade scale in 1981.

1.3 Therapeutic Method (1) systemic administration: treatment group prescription of the present invention: Fang Yong: Rhizoma Corydalis 10g, Radix Rehmanniae Preparata 15g, Radix Angelicae Sinensis 12g, Radix Astragali 10g, Radix Achyranthis Bidentatae 11g, Radix Salviae Miltiorrhizae 12g, Radix Polygoni Multiflori Preparata 11g, Rhizoma Atractylodis Macrocephalae 15g, Poria 13g, Radix Curcumae 10g, Flos Carthami 12g, Rhizoma Chuanxiong 11g, Caulis Spatholobi 10g, Pheretima 11g, Herba Dendrobii 12g, Eupolyphaga Seu Steleophaga 11g, Cortex Cinnamomi 13g, Semen Sinapis Albae 10g, Radix Paeoniae Rubra 11g, matched group adopts subcutaneous injection of insulin blood sugar lowering, infection control, cultivation of cervical secretions is got in part, carry out antibiotic therapy, adopt depression of order ladder type to select antibiotic, whole body gives ligustrazine, prostaglandin E, the blood circulation promoting and blood stasis dispelling such as vancomin, expander, the symptomatic treatment J such as trophic nerve.(2) local application: actively remove the tissue, fascia, tendon, broken bone of wound surface necrosis, withered toes or toe-end, clean with povidone iodine and normal saline.Treatment group external preparation of the present invention, Fang Yong: Herba Asari 20g, Radix Clematidis 18g, Radix Notoginseng 15g, Olibanum 17g, Myrrha 17g, Radix Et Rhizoma Rhei 19g, Cortex Phellodendri 15g, dried Alumen 20g, Rhizoma Smilacis Glabrae 15g, Radix Sanguisorbae preparata 19g, Flos Carthami 20g, Fructus Cnidii 17g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Rhizoma Drynariae 15g makes powder.Powder spreads on instep, and meche spreads on wound surface, and sinus tract also will be clogged, and the aseptic adjuvant wrapping of external application, adopts the method for nibbling to remove gradually slough, and 3d changes dressings 1 time; Matched group gives ethacridine gauze soak wound surface, then removes gradually slough, and debridement process continues with the soak of ethacridine gauze, after fresh granulation tissue exposes, uses gentamycin, 654-2 medicinal liquid soaks, the aseptic adjuvant of external application, and 3d changes dressings 1 time.Two groups all taking 25d as 1 course for the treatment of.

1.4 observation index are observed the secretions situation of wound surface, the newborn situation of the granulation of local woanded surface after medication, the speed of growth, fascia are repaired to situation, and after wound secretion bacteria cultivation results observation medication, variation, growth or the disappearance situation of bacterial species are observed.

1.5 criterions of therapeutical effect are with reference to relevant criterion.Cure: ulcer area heals completely, form crust or cicatrix.Effective: ulcer area is obviously dwindled, 1/2 before < treatment, merocrine secretion's thing obviously reduces, and slough major part comes off or part granulation new life.Effective: ulcer area is dwindled, but 1/2 before > treatment.Invalid: ulcer area is without obviously dwindling, and secretions is without obvious minimizing, local without significant change or deterioration person.

1.6 statistical procedures application SPSS11.0 statistical softwares.Measurement data is so that (x ± s) represent adopts t inspection.

2 results

2.1 liang of group curative effects are relatively in Table l.From table 1, treatment group curative effect is better than matched group (P<0.05).

Table 1 liang relatively n (%) of group patient curative effect

Group

Number

Cure

Effective

Effectively

Invalid

Total effective rate

Treatment group

20

14(70)

3（15）

2(10)

1（5）

95

Matched group

20

6(30)

8（40）

2(10)

4（20)

80

With matched group comparison, △ P<0.05.

3 discuss

Diabetic foot is one of complication that diabetes are serious, is that diabetics is lethal, the major reason disabling, and clinical manifestation is mainly taking acral pain infection, ulcer, gangrene as main, and biped is more serious.Footbath with traditional Chinese medicines obtains curative effect by the dual function of heat, medicine.The heat energy flesh muscle that relaxes, loose space between skin and muscles, promoting blood circulation to remove obstruction in the collateral, medicine is under the effect of heat energy, directly absorbed and enter blood network by skin hole, acupuncture points on the human body etc., defeated cloth whole body and bring into play drug action, can blood circulation promoting, blood vessel dilating, improves surrounding tissue nutrition, excitating organism self-regulation function.

According to patient's disease, select corresponding prescription, great majority are activating blood and removing stasis drug, these medicines can be expanded lower limb vascular, suppress platelet aggregation, reduce blood viscosity, improve lower limb blood circulation, and diabetes are had to obvious curative effect.But should note: (1) should suitably be strengthened this disease dosage; (2) avoid damaging healthy energy, be equipped with qi-invigorating, blood-nourishing medicinal; (3) in medication, to note monitoring coagulation function and hematoblastic variation.Treatment key is benefiting vital QI and blood, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting.Improve on the one hand the local blood capillary obstacle of lower limb, blood circulation promoting, comes off slough as early as possible, reaches tissue repair; The medicine such as oral blood sugar lowering, blood pressure lowering, blood fat reducing on the other hand, effectively controls blood glucose, regulates blood viscosity, reduces blood pressure; To prevent foot to infect, enhancing human body immunity function simultaneously.Endo-medicine is effectively controlled blood glucose, regulates blood viscosity, is reduced blood pressure.Oral medicinal herb and external application can improve ulcer surface microcirculation effectively, increase the groundwater increment of local organization, promote the regeneration of inflammation absorption and granulation tissue and epithelium, reach the object of ulcer surface wound healing.

Claims

1. a Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot, is characterized in that, formed by endo-medicine and external used medicine,

In described endo-medicine, the ratio of weight and number of various crude drug is: 10～20 parts of Rhizoma Corydalis, 10～20 parts, Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts, Poria, 10～20 parts of Radix Curcumaes, 10～20 parts, Flos Carthami, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Caulis Spatholobis, 10～20 parts of Pheretimas, 10～20 parts of Herba Dendrobiis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Cortex Cinnamomis, 10～20 parts of Semen Sinapis Albaes, 10～20 parts of Radix Paeoniae Rubra;

In described external used medicine, the ratio of weight and number of various crude drug is: 10～30 parts of Herba Asaris, 10～30 parts of Radix Clematidis, 10～30 parts of Radix Notoginseng, 10～30 parts of Olibanums, 10～30 parts of Myrrhas, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 10～30 parts of dried Alumens, 10～30 parts of Rhizoma Smilacis Glabraes, 10～30 parts of Radix Sanguisorbae preparatas, 10～30 parts, Flos Carthami, 10～30 parts of Fructus Cnidiis, 10～30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～30 parts of Rhizoma Drynariae.

2. the Chinese medicine composition for the treatment of according to claim 1 QI and blood deficiency blood stasis type diabetic foot, is characterized in that,

In described endo-medicine, the ratio of weight and number of various crude drug is: 10～15 parts of Rhizoma Corydalis, 10～15 parts, Radix Rehmanniae Preparata, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Achyranthis Bidentataes, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts, Poria, 10～20 parts of Radix Curcumaes, 10～20 parts, Flos Carthami, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Caulis Spatholobis, 10～20 parts of Pheretimas, 10～20 parts of Herba Dendrobiis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Cortex Cinnamomis, 10～20 parts of Semen Sinapis Albaes, 10～20 parts of Radix Paeoniae Rubra;

In described external used medicine, the ratio of weight and number of various crude drug is: 10～15 parts of Herba Asaris, 10～15 parts of Radix Clematidis, 10～15 parts of Radix Notoginseng, 10～15 parts of Olibanums, 10～15 parts of Myrrhas, 10～15 parts of Radix Et Rhizoma Rhei, 10～15 parts of Cortex Phellodendris, 10～30 parts of dried Alumens, 10～30 parts of Rhizoma Smilacis Glabraes, 10～30 parts of Radix Sanguisorbae preparatas, 10～30 parts, Flos Carthami, 10～30 parts of Fructus Cnidiis, 10～30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～30 parts of Rhizoma Drynariae.

3. the Chinese medicine composition for the treatment of according to claim 1 QI and blood deficiency blood stasis type diabetic foot, is characterized in that,

In described endo-medicine, the ratio of weight and number of various crude drug is: 10～20 parts of Rhizoma Corydalis, 10～20 parts, Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts, Poria, 10～15 parts of Radix Curcumaes, 10～15 parts, Flos Carthami, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Caulis Spatholobis, 10～15 parts of Pheretimas, 10～15 parts of Herba Dendrobiis, 10～15 parts of Eupolyphaga Seu Steleophagas, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Semen Sinapis Albaes, 10～15 parts of Radix Paeoniae Rubra;

In described external used medicine, the ratio of weight and number of various crude drug is: 10～30 parts of Herba Asaris, 10～30 parts of Radix Clematidis, 10～30 parts of Radix Notoginseng, 10～30 parts of Olibanums, 10～30 parts of Myrrhas, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 10～15 parts of dried Alumens, 10～15 parts of Rhizoma Smilacis Glabraes, 10～15 parts of Radix Sanguisorbae preparatas, 10～15 parts, Flos Carthami, 10～15 parts of Fructus Cnidiis, 10～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～15 parts of Rhizoma Drynariae.

4. a preparation method for the treatment of the Chinese medicine composition of QI and blood deficiency blood stasis type diabetic foot as described in any one in claim 1～3, is characterized in that, the dosage form of described Chinese medicine composition endo-medicine is granule, and its preparation method comprises:

A. described crude drug is put into pulverizer grinding and sieving;

5. preparation method according to claim 4, is characterized in that, in described step a, described crude drug is put into after pulverizer is pulverized and is crossed 100-120 order dusting cover, and the fine powder amount that enable pass is crossed sieve aperture is reaching 30%-40%, collects by the raw material fine powder of sieve aperture for subsequent use.

6. preparation method according to claim 4, is characterized in that, in described step b, particulate matter remaining after sieving is put into 10 times of amount 75% ethanol heating and refluxing extraction of weight portion 2 times, each 1～2 hour, 2 extracting solution is merged and is left standstill.

7. according to the Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot described in any one in claim 1～3, it is characterized in that, in described Chinese medicine composition, medicine for external use agent type is powder, and its preparation method comprises: first Herba Asari and Radix Notoginseng are extracted according to described portion rate, make crystallization; Component described in all the other is mixed by proportioning except dried Alumen, drop into pulverizer and be ground into fine powder, after fine powder sieves, put into acid and alkali-resistance infusion kettle, decoct 1-2 hour, filter; Filtering residue adds water and decocts 1-2 hour again, filters; Mix extracted twice liquid, carry out squeeze and filter, after separation, get filtrate, extracted twice liquid concentrate drying is become to powder, mix the crystal that distillation obtains, evener by mixing after dried Alumen pulverizing, after ultraviolet radiation for sterilizing and disinfecting, make powder.

8. Chinese medicine composition according to claim 7, is characterized in that the extraction of described Herba Asari and Radix Notoginseng is steam distillation or supercritical fluid extraction.

9. according to the Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot described in any one in claim 1～3, it is characterized in that, the dosage form for oral administration of described Chinese medicine composition is: film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation or plaster; Exterior-applied formulation is: foot bath agent, tincture, powder, unguentum, spray, gauze agent, membrane agent or application.