CN102847063A - Traditional Chinese medicinal composition for treating qi and blood deficiency blood stasis type diabetic feet, and its preparation method - Google Patents

Abstract

The invention discloses a traditional Chinese medicinal composition for treating the qi and blood deficiency blood stasis type diabetic feet. The symptoms of the qi and blood deficiency blood stasis type diabetic feet are common in the restoration stage of the diabetic foot disease, and comprise lasting wound disunion, dilute fester, amyotrophy and weakness light tongue nature, thin and white tongue fur, chest distress, purple face, body fatness, feebleness, encrusted affect foot skin, ecchymosis, stiffness, numbness and the like. The composition comprises oral medicines and external medicines, wherein the oral medicines comprise Rhizoma Corydalis, Radix Rehmanniae Preparata, Chinese angelica, Radix Astragali, Achyranthes bidentata, Salvia miltiorrhiza, prepared Polygonum multiflorum Thunb, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Curcumae Aromaticae, safflower, Ligusticum wallichii, Millettia dielsiana, lumbricus, dendrobium, ground beetle, Chinese cassia, Semen Brassicae and Radix Paeoniae Rubra; and the external medicines comprise Manchurian wildginger, Radix Clematidis, Panax Notoginseng, Boswellia carteri, myrrh, rheum officinale, Amur Corktree Bark, dried alum, Glabrous Greenbrier Rhizome, fried Radix Sanguisorbae, safflower, Fructus Cnidii, Bletilla striata and Rhizoma Drynariae. The composition has the efficacies of qi and blood tonifying, channel freeing and blood circulation stimulating, channel warming and cold dispelling, stasis removing and pain relieving, qi and blood benefiting, and internal heat and dysphoria removing when the composition is orally taken, and has the efficacies of blood circulation activating, stasis removing, inflammation removing and flesh engendering when the composition is externally used. On one hand, the local micro-vascular impairment of the lower limbs is improved and the blood circulation is promoted to make necrotic tissues shed as fast as possible in order to reach tissue restoration; on the other hand, the oral medicines can effectively control the blood sugar, adjust the blood viscosity and reduce the blood pressure; and simultaneously the food infection is prevented to enhance the body immunity.

Description

A kind of Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot and preparation method thereof.

Background technology

Over nearly 20 years, the pathogenetic understanding of China's traditional Chinese medical science bound pair diabetic foot in system progressively deeply.Representational doctor family points out that basis of diabetic foot is deficiency of both QI and YIN, and different TCM syndrome types is blood stasis due to qi deficiency, and standard card is that damp and hot heap soil or fertilizer over and around the roots is contained, and the development trend of vascular lesion and syndrome of blood stasis increases progressively by the order of deficiency of both QI and YIN, blood stasis due to qi deficiency, damp and hot heap soil or fertilizer over and around the roots Sheng, and the state of an illness also increases the weight of thereupon.During this patient is according to the observation, the aged, without obvious symptom more than three, common uncomfortable in chest, face is purple, fat, weak, suffer from sufficient squamous and dry skin, ecchymosis, stiff, numb etc., pathogenesis is the blood stasis stagnation of phlegm, healthy energy is deficient.

Also have the doctor to think that primary disease mainly is deficiency of both QI and YIN, the passages through which vital energy circulates stasis blocking due to the acra mistake is supported, always belongs to the card of deficiency in origin and excess in superficiality, and take deficiency of both QI and YIN as this, the passages through which vital energy circulates stasis blocking is mark.Spleen, kidney two void, coagulation of QI-blood, meridians intercept, and the yang deficiency blood stasis is that the primary disease morbidity is basic.Primary disease is started in quenching one's thirst, and belongs to hyperactivity of fire caused by deficiency of YIN, and heat Tianjin blood that burns leads to blood stasis, cause limbs to lose and support, the evil poison of multiple sense, so acra fester and form necrosis, its basic pathogenesis is weakened body resistance blood stasis, accumulates in the pyretic toxicity.According to the clinical observation to diabetic foot tendon degeneration necrosis disease (muscle cellulitis), point out that its pathogenesis is: old kidney liver degradation, gas is cloudy to be consumed, not removing dampness of gas, not nourishing muscle and tendon of the moon, with the passing of time the rotten poison of muscle damage is cellulitis.Think the early stage deficiency of both QI and YIN of primary disease, the venation discord, mid-term, deficiency of qi and blood accumulate in the noxious dampness, late period the hepatic and renal YIN deficiency, the stagnation of phlegm blood stasis.

The pathogenesis of diabetic foot mainly ascribes heat and the stasis of blood to, and the cloudy liquid virtual loss of diabetics is given birth in the deficiency-heat, and the consumption body fluid that burns forms the stasis of blood, or disease damage and sun, so that deficiency of both YIN and YANG, and yang deficiency cold coagulation and cause the stasis of blood; Blockage of the vessel, failure of skin and muscle to be nourished, apathy is subject to wound, the exopathogen invasion of taking advantage of a weak point in opponent's defence, strongly fragrant and heat-transformation, or because of the polyphagia delicious food, endogenous dampness, moist dysentery, the damp and hot stasis of blood is knot and falling ill mutually.

Diabetic foot refers to the large small artery of diabetics whole body, particularly the artery of lower extremity sclerosis of blood vessels causes that thrombosis appears in small artery on every side, form angiostenosis and obturation, cause patient's foot blood supply insufficiency, add diabetic neuropathy and the foot anaesthesia that causes and a kind of severe complication of damage.Its pathological changes main damage meridians, blood vessel, skin, tendon, even skeleton make the patient show as intermittent claudication, lower limb tranquillization pain, and severe patient skin ulceration, withered, blackening, even the foot gangrene occurs and cause amputation to disable.

QI and blood deficiency blood stasis type diabetic foot, this disease is more common in the convalescent period of diabetic foot, the lasting disunion of performance wound surface, pus is rare clearly, amyotrophy is weak, pale tongue, thin white fur of tongue, old kidney liver degradation, gas is cloudy to be consumed, not removing dampness of gas, and not nourishing muscle and tendon of the moon, with the passing of time the rotten poison of muscle damage is cellulitis.Deficiency of both QI and YIN, venation discord, mid-term, deficiency of qi and blood accumulate in the noxious dampness, late period the hepatic and renal YIN deficiency, the stagnation of phlegm blood stasis.During the patient is, the aged, without obvious symptom more than three, common uncomfortable in chest, face is purple, fat, weak, suffer from sufficient squamous and dry skin, ecchymosis, stiff, numb etc., proposing pathogenesis is the blood stasis stagnation of phlegm, healthy energy is deficient.

Because diabetics is in hyperglycemia state for a long time, glycolated hemoglobin is high, and the erythrocyte oxygen carrying capacity is poor, and blood viscosity increases, and causes sclerosis of blood vessels, becomes fragile, thickens, and the ability of red blood cell deformation descends, and blood supply is not enough; On the other hand, the blood viscosity increase also causes vascular inflammation, more than many reasons, can cause the vascularization thrombosis, cause blood vessel to produce inaccessible phenomenon, cause blood supply seriously to lack, the local organization malnutrition of foot, because " foot " is centrifugal farthest dirty, the vascular occlusion phenomenon is the most serious, be easy to cause edema, blackout, rotten, downright bad, it is downright bad to form foot.

Clinical and experiment shows, diabetic gangrene patient's ubiquity stagnation of blood stasis, the pathological change of venation numbness resistance.Show as instep and posterior tibial artery and beat and weaken even disappear, Abnormal Blood Rheology, whole blood viscosity increases, the platelet aggregation ability increases, and clotting mechanism is unusual, and fibrin increases, fibrinbioplast reduces, and microcirculation disturbance, loop eject existing tuberosity, the pipe loop is smudgy, blood flow anomalies, and broken string presents lumps, hemocyte is assembled, venous plexus expansion under vein loop and the nipple, ecchymosis etc. appears in loop week, and microcirculation causes abnormal change to embody the essence of traditional Chinese medical science diabetes necrosis.

The traditional Chinese medical science is emphasized " disease is not controlled first, and anti-overweighting controlled ", and the generation of prevent diabetes foot is more urgent and important more than the treatment diabetic foot.Studies show that scalding and wear improper footgear and pruning toenail improper etc. is the physical factor that causes diabetic foot.The patient should forbid that foot is placed hot water bag or heat is filled up, and avoids scalding foot; Should wear soft, the loose ventilative shoes of the matter of fitting, avoid light to wear footwear, shoes can not be uneven, crackle is arranged, and changes every other day the footwear money, in order to avoid the long-term pressurized of foot's same position as far as possible.Can not pass tight shoes and socks, in order to avoid affect the blood circulation of foot: use file when pruning toenail and with vertical direction toenail is polished.After foaming foot, use bibulous towel and softly and thoroughly dry, especially should keep dry between toe space.Can not the Overexertion friction, to avoid skin injury.So strengthen the educational propaganda of pedopathy, the self-foot health promotion consciousness and the ability that improve diabetics are particularly important.

Doctor trained in Western medicine can not solve the sufferer misery for this disease at all, diabetic foot (diabetic foot, DF) be modal complication in the diabetics, 15%～25 ulcer of foot in various degree arranged in diabetics, wherein about 1% patient because of the development of ulcer finally by amputation.The cause of disease of DF is Lower Distal Extremities neuropathy due to the diabetes and the comprehensive pathological change of Lower Distal Extremities vascular lesion, the pathophysiological change that its skin of lower extremity and tissue injury occur on the basis of metabolism disorder and blood vessel, neuropathy often.Because the complexity of pathological changes changes, and causes single therapy not prove effective, and usually adopts the way of Comprehensive Treatment.In a word, Chinese medicine comprehensive treating diabetes foot has been obtained certain curative effect clinically, has tentatively demonstrated significant advantage; But effectively prescription needs dialectical use, and specific aim is relatively poor, and the clinical practice degree is not high.

Summary of the invention

Technical problem to be solved by this invention is, a kind of patient's of alleviating slight illness is provided, and wound healing reduces amputation rate, improves patients ' life quality purpose Chinese medicine composition; The present invention adopts the Chinese crude drug of different properties, qi and blood tonifying for oral administration; Dispelling cold by warming the meridian; Stasis-dispelling and pain-killing; Benefiting vital QI and blood is laid equal stress on; The external blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting.Improve on the one hand the local blood capillary obstacle of lower limb, blood circulation promoting comes off slough as early as possible, reaches tissue repair; Endo-medicine is effectively controlled blood glucose, regulates blood viscosity, is reduced blood pressure on the other hand; To prevent simultaneously foot to infect the enhancing human body immunity function; Oral medicinal herb and external application can improve the ulcer surface microcirculation effectively, increase the groundwater increment of local organization, promote the regeneration of inflammation absorption and granulation tissue and epithelium, reach the purpose of ulcer surface wound healing.Adopt Chinese medicine internal and external application method treatment diabetic foot to shorten the time of ulcer healing, evident in efficacy, clinic is applied.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot, this disease is more common in the convalescent period of diabetic foot, the lasting disunion of performance wound surface, pus is rare clearly, and amyotrophy is weak, pale tongue, thin white fur of tongue; Formed by endo-medicine and external used medicine;

The ratio of weight and number of various crude drug can be 10～20 parts of Rhizoma Corydalis in the described endo-medicine, 10～20 parts in Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts in Poria, 10～20 parts of Radix Curcumaes, 10～20 parts on Flos Carthami, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Caulis Spatholobis, 10～20 parts of Pheretimas, 10～20 parts of Herba Dendrobiis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Cortex Cinnamomis, 10～20 parts of Semen Sinapis Albaes, 10～20 parts of Radix Paeoniae Rubra;

The parts by weight of various crude drug can be 10～30 parts of Herba Asaris, 10～30 parts of Radix Clematidis, 10～30 parts of Radix Notoginseng in the described external used medicine, 10～30 parts of Olibanums, 10～30 parts of Myrrhas, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 10～30 parts of dried Alumens, 10～30 parts of Rhizoma Smilacis Glabraes, 10～30 parts of Radix Sanguisorbae preparatas, 10～30 parts on Flos Carthami, 10～30 parts of Fructus Cnidiis, 10～30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～30 parts of Rhizoma Drynariae.

The Chinese medicine composition of described treatment QI and blood deficiency blood stasis type diabetic foot, the ratio of weight and number of various crude drug can also be 10～15 parts of Rhizoma Corydalis, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Radix Angelicae Sinensis in its described endo-medicine, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Achyranthis Bidentataes, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts in Poria, 10～20 parts of Radix Curcumaes, 10～20 parts on Flos Carthami, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Caulis Spatholobis, 10～20 parts of Pheretimas, 10～20 parts of Herba Dendrobiis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Cortex Cinnamomis, 10～20 parts of Semen Sinapis Albaes, 10～20 parts of Radix Paeoniae Rubra;

The ratio of weight and number of various crude drug can also be 10～15 parts of Herba Asaris, 10～15 parts of Radix Clematidis, 10～15 parts of Radix Notoginseng in the described external used medicine, 10～15 parts of Olibanums, 10～15 parts of Myrrhas, 10～15 parts of Radix Et Rhizoma Rhei, 10～15 parts of Cortex Phellodendris, 10～30 parts of dried Alumens, 10～30 parts of Rhizoma Smilacis Glabraes, 10～30 parts of Radix Sanguisorbae preparatas, 10～30 parts on Flos Carthami, 10～30 parts of Fructus Cnidiis, 10～30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～30 parts of Rhizoma Drynariae.

The Chinese medicine composition of described treatment QI and blood deficiency blood stasis type diabetic foot, the ratio of weight and number of various crude drug also can be 10～20 parts of Rhizoma Corydalis, 10～20 parts in Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis in its described endo-medicine, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts in Poria, 10～15 parts of Radix Curcumaes, 10～15 parts on Flos Carthami, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Caulis Spatholobis, 10～15 parts of Pheretimas, 10～15 parts of Herba Dendrobiis, 10～15 parts of Eupolyphaga Seu Steleophagas, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Semen Sinapis Albaes, 10～15 parts of Radix Paeoniae Rubra;

The ratio of weight and number of various crude drug also can be 10～30 parts of Herba Asaris, 10～30 parts of Radix Clematidis, 10～30 parts of Radix Notoginseng in the described external used medicine, 10～30 parts of Olibanums, 10～30 parts of Myrrhas, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 10～15 parts of dried Alumens, 10～15 parts of Rhizoma Smilacis Glabraes, 10～15 parts of Radix Sanguisorbae preparatas, 10～15 parts on Flos Carthami, 10～15 parts of Fructus Cnidiis, 10～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～15 parts of Rhizoma Drynariae.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of QI and blood deficiency blood stasis type diabetic foot, the dosage form of described Chinese medicine composition endo-medicine is granule, and its preparation method comprises: a. puts into the pulverizer grinding and sieving with described crude drug

B. the rear remaining particulate matter that will sieve is put into the ethanol heating and refluxing extraction 2 times;

C. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol and spray drying get medicated powder; The fine powder that mixing sieves obtains is packed in the bag.

Among the described step a, described crude drug is put into pulverizer pulverize the rear 100-120 of mistake order dusting cover, the fine powder amount that enable pass is crossed sieve aperture is reaching 30%-40%, collects by the raw material fine powder of sieve aperture for subsequent use.

Among the described step b, the rear remaining particulate matter that sieves can be put into 10 times of amount 75% ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging be left standstill.

Among the described step c, above-mentioned extracted twice liquid can be merged 1.35 filtrate when the concentrating under reduced pressure relative density is 80 ℃, Recycled ethanol, gained filtrate is adjusted proportion to 1.06, pass into spray dryer and carry out spray drying, the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m ², the hothouse hot stream temperature is 80 ℃-100 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving is mixed in the bag of packing into raw material medicated powder.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of QI and blood deficiency blood stasis type diabetic foot again, and medicine for external use agent type is powder in the described Chinese medicine composition, and its preparation method comprises:

First Herba Asari and Radix Notoginseng are extracted according to described portion rate, make crystallization; All the other described components are mixed by proportioning except dried Alumen, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, decocted 1-2 hour, filter; Filtering residue adds water and decocted 1-2 hour again, filters; Mix extracted twice liquid, carry out squeeze and filter, get filtrate after the separation, extracted twice liquid concentrate drying is become powder, mix the crystal that distillation obtains, even with mixing after the dried Alumen pulverizing again, behind ultraviolet radiation for sterilizing and disinfecting, make powder.

The extraction of described Herba Asari and Radix Notoginseng can steam distillation, supercritical fluid extraction.

For solving the problems of the technologies described above, the present invention also provides a kind of pharmaceutical dosage form for the treatment of the Chinese medicine composition of QI and blood deficiency blood stasis type diabetic foot, the dosage form for oral administration of described Chinese medicine composition can for: tablet, pin powder, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation or plaster; Exterior-applied formulation can be foot bath agent, tincture, powder, unguentum, spray, gauze agent, membrane agent or application.

For solving the problems of the technologies described above, its using method that it is the loose powder agent that the present invention also provides a kind of exterior-applied formulation for the treatment of QI and blood deficiency blood stasis type diabetic foot is: can clean the skin ulcer face with 3% hydrogen peroxide first first, wipe out slough, clean with normal saline again, periphery skin 75% alcohol disinfecting, then with loose powder agent of the present invention, be dispersed in equably on the skin ulcer face, to cover and to surpass whole skin ulcer faces to surrounding normal skin, cover again 2～3 layers of sterile gauze, fix with Breathable adhesive tape, change dressings 1 day 1 time, treating 20 days is 1 course for the treatment of.

The present invention selects corresponding prescription according to patient's disease, and great majority are blood circulation promoting and blood stasis dispelling, the medicine of heat clearing away and internal heat reducing, and these medicines can be expanded lower limb vascular, suppress platelet aggregation, reduce blood viscosity, improve lower limb blood circulation, and diabetes are had obvious curative effect.But should note: (1) should suitably be strengthened this disease dosage; (2) avoid damaging healthy energy, be equipped with qi-invigorating, blood-nourishing medicinal; (3) to note monitoring coagulation function and hematoblastic variation in the medication.

The present invention is Chinese medicine composition, can reach to alleviate patient's slight illness, and wound healing reduces amputation rate, improves the patients ' life quality purpose; The present invention adopts the Chinese crude drug of different properties, qi and blood tonifying, benefiting vital QI and blood, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting.Improve on the one hand the local blood capillary obstacle of lower limb, blood circulation promoting comes off slough as early as possible, reaches tissue repair; Endo-medicine is effectively controlled blood glucose, regulates blood viscosity, is reduced blood pressure on the other hand; To prevent simultaneously foot to infect the enhancing human body immunity function; Oral medicinal herb and external application can improve the ulcer surface microcirculation effectively, increase the groundwater increment of local organization, promote the regeneration of inflammation absorption and granulation tissue and epithelium, reach the purpose of ulcer surface wound healing.Adopt Chinese medicine internal and external application method treatment diabetic foot to shorten the time of ulcer healing, evident in efficacy, clinic is applied.

The specific embodiment

QI and blood deficiency blood stasis type diabetic foot, this disease is more common in the convalescent period of diabetic foot, the lasting disunion of performance wound surface, pus is rare clearly, amyotrophy is weak, pale tongue, thin white fur of tongue, old kidney liver degradation, gas is cloudy to be consumed, not removing dampness of gas, and not nourishing muscle and tendon of the moon, with the passing of time the rotten poison of muscle damage is cellulitis.Deficiency of both QI and YIN, venation discord, mid-term, deficiency of qi and blood accumulate in the noxious dampness, late period the hepatic and renal YIN deficiency, the stagnation of phlegm blood stasis.During the patient is, the aged, without obvious symptom more than three, common uncomfortable in chest, face is purple, fat, weak, suffer from sufficient squamous and dry skin, ecchymosis, stiff, numb etc., proposing pathogenesis is the blood stasis stagnation of phlegm, healthy energy is deficient.

The Chinese medicine ancient medicine has many discussions and record to diabetes complicated carbuncle.Diabetic foot belongs to the accompanied symptoms " necrosis " of traditional Chinese medical science diabetes.About in diabetes patient concurrent " necrosis " traditional Chinese medical science ancient books many discussions being arranged.Tang's Sun Simiao " prescriptions worth thousand gold " has the record of " people who quenches one's thirst is healed and do not healed, and often pondering over has large carbuncle, and the people that whichever is quenched one's thirst must finally, die in large carbuncle also so guard against in DAGU internode generation carbuncle ".Sui Dynasty's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases " record, diabetes has eight times, comprising " carbuncle ".The Wang Tao Tang Dynasty " medical secrets of official " record, " diabetes ... multiple carbuncle ".Yuan Dynasty Zhu Rui chapter " precious mirror of hygiene " record " person's of quenching one's thirst foot knee joint is sent out malignant boil, to stubbornly refuse rescue " ...Unit's Zhu Zhenheng " danxi's experiential therapy " has been put down in writing the clinical symptoms of diabetes necrosiss in detail, point out " necrosis is born between the toes; ... come into being such as the foxtail millet Rubus pectinellus a bit; color of the leather is purple dark; just as boiling Fructus Jujubae; black gas spreads, rot to prolong out ... sprinkle the fire combustion just as soup " traditional Chinese medical science thinks roughly that to the pathogenic inducement of diabetic foot three aspects are arranged: the heresy of (1) impression cold.The diabetics foot is subjected to the heresy of cold, or paddles and drop down the river or sense is cold or sweating entry or field, snow day are slept in the open etc., all can cause the cold-evil to attack outward, coagulation of QI-blood, passages through which vital energy circulates impatency and falling ill ...What we added up that prompting directly causes by catching a cold accounts for 7%～9% of patient's number; (2) the burning hot heresy of impression.Diabetics, the deficiency of YIN are this, scorchingly experience again burning hot heresy for mark, and be then cloudy empty, scorchingly more contains, and burning hot heresy is gathered in the part, corrosion flesh and blood and be pus of carbuncle.We add up prompting and account for 13%～15% of patient's number by what the burning hot heresy of impression such as burn and scald caused; (3) external injury.External injury on the direct occurrence cause of diabetic foot in the highest flight, various external injuries (friction injury, prune accidentally, foreign object damage, callus, mosquito bite, iatrogenic injury, postoperative do not heal) directly injure human body, cause local coagulation of QI-blood, or because of after the damage, cause the passages through which vital energy circulates stasis blocking, QI-blood circulation is not normal and fall ill.External injury causes the patient and accounts for more than 60% of patient's number according to statistics.

Diabetic foot exist the weakened body resistance and domination of pathogen two aspect factors, statistics accounting for more than 95%, and think its be weakened body resistance or domination of pathogen single factors due to person's less than 5%.Weakened body resistance person comprises deficiency of both QI and YIN, the deficiency of vital energy, the deficiency of YIN, QI and blood deficiency, asthenia of both the spleen and kidney, yang deficiency, deficiency of both YIN and YANG etc. ' ".It is maximum to think that clearly diabetic foot occurs on the deficiency of both QI and YIN basis person, accounts for 47%.Domination of pathogen person includes the stasis of blood, stagnation of phlegm, damp and hot, pyretic toxicity, ecchymosis etc.Think that diabetic foot occurs to reach 83% with the blood stasis relative.The observational study of diabetic foot different lesions stage clinical symptoms, tongue pulse condition and tcm syndrome is found that diabetic feet is in early days take void as main according to us, take deficiency of qi and yin or yang-energy virtual loss as common, accompanied blood stasis and venation discord; Patient's syndrome performance in mid-term is complicated, if invade in the exopathogen, healthy energy remains, and struggle between vital QI and pathogen shows take the domination of pathogen as main, with dampness-heat in the liver and gallbladder, and dominance of heat in the interior, it is main accumulateing in the noxious dampness, if healthy energy virtual loss, then simulataneous insufficiency and excessive; The many courses of disease of the patient in late period are both of a specified duration, and consumption is hindered healthy energy, and simulataneous insufficiency and excessive is pressed from both sides the mutual resistance of the expectorant stasis of blood as main take the hepatic and renal YIN deficiency or deficiency of spleen-YANG and kidneyYANG.Diabetic foot can occur in diabetes the moon thanks to scorching, deficiency of both QI and YIN, deficiency in both YIN and YANG stages, and blood stasis is the important pathologic basis of its genesis, and multifarious external injury occupies an important position in the diabetic foot morbidity.Present research prompting, diabetics are on the pathologic basis of deficiency of both QI and YIN, and the deficiency of vital energy is without trying hard to recommend the blood operation, and thrombosis or obstruction sering cause the stasis of blood; Hyperactivity of fire caused by deficiency of YIN decocts body fluid, makes blood viscid, and operation does not freely cause the stasis of blood; After blood stasis formed: (1) blood lost the nutrition of histoorgan and moistens effect; (2) blood stasis is difficult carrier gas in interior, defends gas and loses it and normally defend the functions such as outer; (3) blood stasis hinders in the part, strongly fragrant and heat-transformation, more cause deficiency of YIN leading to consumption of QI, very the person becomes the poison of stagnant heat. in the sunset paathogenic factor, the evil cold coagulation of cold causes the stasis of blood and increases the weight of the state of an illness, but external injury direct effect part causes coagulation of QI-blood, and pathogenic heat, damp, malicious heresy are invaded into pyretic toxicity, diseases caused by noxions dampness, is combined with local pathological product then to form hot and humid ecchymosis and become mutually trouble.It more than may be the main mechanism that diabetic foot causes a disease.But clinical research also notification portion patient does not show the syndromes such as the gas deficiency of YIN or yang deficiency, and only shows as that pyretic toxicity pents up or damp and hot, the syndrome such as noxious dampness pents up, and some patients were is also arranged, and does not show the existence of syndrome of blood stasis.So, to thoroughly illustrate the basic pathogenesis change law of diabetic foot, still need do a large amount of work, particularly in conjunction with the modern study achievement, by experiment chamber auxiliary examination, relation between the various Microscopics of clear and definite diabetic foot and the tcm syndrome makes it to complement each other with the observation of traditional Chinese medical science integral macroscopic syndrome, and the pathogenesis that finally discloses diabetic foot is crucial.The traditional Chinese medical science is thought: the core cause of disease of diabetic foot is the deficiency of vital energy sun cold coagulation that declines, and the deficiency of vital energy can not handsome blood, and sun declines can not be warm, and the cold coagulation then blood stasis of blood stagnates not all rightly, and then acral necrosis of a specified duration forms necrosis.Diabetic acromelic gangrene belongs to the categories such as the traditional Chinese medical science " diabetes ", " numbness ", " necrosis ".Chinese medicine thinks that the pathogenesis of primary disease mainly is to quench one's thirst with the passing of time, deficiency of both QI and YIN, passages through which vital energy circulates stasis blocking, hematogenous blockage, acra lose supports, in addition damp invasion of lower energizer, the pyretic toxicity blood stasis forms BI-syndrome involved the blood vessels, necrosis, and is specific as follows: stagnation of blood stasis, with the passing of time the resistance of venation numbness quenches one's thirst, because of scorching in the deficiency of YIN, and cloudy liquid virtual loss, scorching inclined to one side Sheng, the bright Tianjin of heat blood, and hyperamization liquid is concentrated, blood viscous, the not smooth stasis of blood of blood is slow, or because scorching yin-damaging and Qi consuming, make deficiency of both QI and YIN, be difficult to transport blood, blood is unable, or because cloudy liquid virtual loss, deficiency of YIN affecting YANG, yang deficiency cold coagulation, blood vessels are lost in warm, all can make hematogenous blockage, form blood stasis.Blood stasis is in case form, because of the resistance of blood vessels numbness, hematogenous blockage cause the limbs part especially acra lose and support and form BI-syndrome involved the blood vessels, necrosis.Clinical and experiment shows, diabetic gangrene patient's ubiquity stagnation of blood stasis, the pathological change of venation numbness resistance.Show as instep and posterior tibial artery and beat and weaken even disappear, Abnormal Blood Rheology, whole blood viscosity increases, the platelet aggregation ability increases, and clotting mechanism is unusual, and fibrin increases, fibrinbioplast reduces, and microcirculation disturbance, loop eject existing tuberosity, the pipe loop is smudgy, blood flow anomalies, and broken string presents lumps, hemocyte is assembled, venous plexus expansion under vein loop and the nipple, ecchymosis etc. appears in loop week, and microcirculation causes abnormal change to embody the essence of traditional Chinese medical science diabetes necrosis.

Radix Astragali air making-up and spleen enlivening in the endo-medicine; The Chinese Angelica blood replonishing tonifying liver; Radix Astragali benefiting qi and supporting yang can be received the effect of Yin grows while yang is generating; The Radix Astragali is infections section key medicine in the side, reuses with the righting QI invigorating, makes the prosperous and short blood of gas, blood stasis dispelling and just not hindering; Chinese Angelica blood replonishing is invigorated blood circulation, promoting tissue regeneration by removing blood stasis; Dredge the meridian passage; Dispelling cold by warming the meridian; The Semen Ziziphi Spinosae resolving depression is dispelled tired, and nourishing YIN and clearing away heat is to moisturize; The Radix Paeoniae Alba blood circulation promoting and blood stasis dispelling; Pheretima, the Eupolyphaga Seu Steleophaga disperse blood stasis and dredge collateral; Stasis-dispelling and pain-killing; Heat-clearing and toxic substances removing; The good medicine of Flos Carthami promoting the flow of QI in the collateral by warming the meridian dissipating blood stasis; Rhizoma Chuanxiong is kind descending, but is longer than again stasis-dispelling and pain-killing of promoting blood circulation to remove obstruction in the collateral, and can assign the foot affected part by priming; Full side's benefiting QI and nourishing blood is with Zhi Qiben, and promoting the flow of QI in the collateral by warming the meridian must answer QI and blood to control its mark, and blood stasis must remove, qi and blood circulation, and the muscle arteries and veins is moistened foster, so all diseases are from removing.The Radix Et Rhizoma Rhei heat clearing away of reducing internal heat, Poria mind tranquilizing and the heart calming, granulation promoting are put on flesh; Semen Persicae, Caulis Spatholobi, Radix Salviae Miltiorrhizae freeing vessels and nourishing heart, broken stagnated blood, tissue regeneration promoting blood, Pheretima the meridian dredging have the effect of blood circulation promoting and blood stasis dispelling.All medicines cooperates, and makes altogether QI and blood fill Sheng, and short its corruption flesh of dispelling is given birth to open sore part convergence.External used medicine has blood circulation promoting and blood stasis dispelling, putrefaction removing and tissue regeneration promoting, draw out the pus put on flesh, the effect of skin moistening granulation promoting.Be applicable to all suppurative wounds, slough does not take off or takes off, and new meat is the survivor not.The Pseudobulbus Bletillae (Rhizoma Bletillae) has putrefaction removing and tissue regeneration promoting, short merit more in the side, and blood vessel dilating is arranged, improves microcirculatory function; Gypsum Fibrosum Preparatum removing dampness sore, granulation promoting are put on flesh; Sanguis Draxonis, Myrrha, the pain relieving of Olibanum promoting blood circulation to remove blood stasis, the hemostasia and promoting granulation sore is conducive to the granulation tissue growth.The endo-medicine dredge the meridian passage; Dispelling cold by warming the meridian; Stasis-dispelling and pain-killing; Heat-clearing and toxic substances removing.Ramulus Cinnamomi has blood vessel dilating in the external side, promotes diaphoresis, the antibiotic effect of easing pain; The blood circulation promoting and blood stasis dispelling such as Flos Carthami have dense, glutinous, the state of aggregation that improve blood, and anticoagulant improves local microcirculation, make blood flow further unobstructed, improve local blood supply, oxygen supply, strengthen the recovery of Nerve conduction.

Herba Dendrobii latin name: Dendrobium.Herba Dendrobii is one of orchid of putting down in writing the earliest during China's ancient Chinese prose is offered.Just on the books in the Shennong's Herbal before 2000.Its direct sum Ganoderma since thousand, Radix Ginseng, Cordyceps etc. equally are listed in top grade Chinese medicine.Its nature and flavor: sweet light little salty.The property belong to clear and rich, benefit is arranged in clear, invigorating middle warmer has clearly.Function cures mainly: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Be used for cloudy impairment of body fluid and lose, the xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.

Rhizoma Corydalis cures mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.Analgesia, calmness, syngignoscism are arranged.. analgesic activity: prove that with electricity irritation mousetail method the Rhizoma Corydalis powder has analgesic activity, it is tired and is 1/10 of opium, and effect continues 2 hours.Hot plate method in mice proves that Corydaline, ugly element all have significant analgesic activity.Rabbit second thermostimulation method and electric summation stimulus method prove that iv second element 15-20mg/kg, ugly plain 10-15mg/kg or first element 30-40mg/kg all have analgesic activity.And with second element, ugly element for the strongest, the first element takes second place.Rat sc second element 50mg/kg or ugly plain 40mg/kg also have the analgesia similar to rabbit and render a service.And the third element also has obvious analgesic activity to analgesic test such as writhing response due to the mouse peritoneal injection acetic acid and electrostimulations, but than a little less than the morphine.Rat can produce toleration to the analgesic activity of second element and ugly element, slow 1 times than morphine of the speed of generation, and and morphine between cross tolerance is arranged; Experiment shows that also the second element finds no addiction.

Radix Rehmanniae Preparata: Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese crude drug, have the YIN nourishing of enriching blood effect, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, the disease such as pass out semen, quench one's thirst, is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.1. all cards of blood deficiency.The sweet Wen Zhirun of this product, the nourishing YIN benefit is smart in hemopoietic, is the key medicine of the tonify deficiency that nourishes blood.Normal and Radix Angelicae Sinensis, the Radix Paeoniae Alba, the same usefulness of Rhizoma Chuanxiong are treated blood deficiency and yellow complexion, and is dizzy, cardiopalmus, insomnia and menoxenia, metrorrhagia and metrostaxis etc. are such as SIWU TANG); If the deficiency of heart-blood severe palpitation can be used together with sedatives such as Radix Polygalae, Semen Ziziphi Spinosaes; If the empty cold in blood of metrostaxis and hyperamization, few abdomen cold type of pain person, can with the tonifying blood and arresting bleeding such as Colla Corii Asini, Folium Artemisiae Argyi, the same usefulness of dispelling cold by warming the meridian medicine, such as Ass-hide Glue and Argyi Leaf Decoction.2. all cards of the hepatic and renal YIN deficiency.This quality is moistened into kidney, kind nourishing kidney yin, and life essence-filling, marrow-benefitting is the key medicine of tonifying kidney-yin.Ancients call it " large tonifying five ZANG-organs is Kidney-Yin ", " mending greatly true water ".Normal be equal to usefulness with Rhizoma Dioscoreae, Fructus Corni, treat the hepatic and renal YIN deficiency, soreness of the waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst etc., but invigorating the liver and kidney, beneficial marrow is such as LIUWEI DIHUANG WAN; Also can be equal to treatment deficiency of YIN osteopyrexia and fever, such as dabuyin pill (" danxi's experiential therapy ") with the Rhizoma Anemarrhenae, Cortex Phellodendri, Carapax Et Plastrum Testudinis.This product benefiting essence-blood, black beard and hair, the compatibilities such as normal and Radix Polygoni Multiflori, Radix Achyranthis Bidentatae, Semen Cuscutae are controlled the blood and essence asthenia early whitening of beard and hair, such as Qibao Meiran Dan (" collection of prescriptions with notes "); This product vital essence replenishing and marrow benifiting, bone and muscle strengthening also can be joined Carapax Et Plastrum Testudinis, Herba Cynomorii, Rhizoma Cibotii etc., the treatment deficiency of the liver and kindey, and the five kinds of growth retardation five kinds of flaccidity in infant is such as Huqian Wan (" collection of prescriptions with notes ").In addition, the Radix Rehmanniae Preparata charcoal can stop blooding, and can be used for the blood deficiency such as metrorrhagia and goes out blood disorder.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." property of medicine opinion " carries it: monarch, and sweet in the mouth, suffering, nontoxic.Can main large migratory arthralgia, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, sputum is removed in appetizing, except cold and heat, lets out under ending.Interarea light is pleased, and preserves youthful looks, and goes to deceive.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in the abdomen is vomited and diarrhoea incessantly, and the insufficiency of stomach-QI cold-dysentery.

Rhizoma Chuanxiong is hot, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." herbal classic " carries it: main apoplexy enters the brain headache, arthralgia due to cold, and the clonic spasm of the muscle emergency, the gold wound, married woman's blood closes loss of fecundity." not Lu " carries it: " except cold moving in the brain, urticaria goes on the face, the order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, the soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." be the good medicine of regulating qi to disperse stagnation.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to invigorate blood circulation latus rectum, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters the blood chamber, and delirium is gone mad; Or blood is vexed interior swollen, and the sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be decided.It is all that cold and heat are handed over work as amenorrhea is obstructed, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are long-pending, or skin infection sufferings and swollen burst uneasyly, be cards of disharmony between QI and blood all, non-Flos Carthami can not be transferred, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, the thrombosis of inhibition, antiinflammatory, analgesic effect are arranged, have the vasoconstrictive effect of eliminating epinephrine, norepinephrine, " tonneau passages through which vital energy circulates " effect is arranged.

Caulis Spatholobi is the dry rattan of pulse family Leguminosae plant spatholobus suberectus Spatholobus suberectusDunn.Autumn, two seasons of winter gather, and remove branch and leaf, and section is dried.The property bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; The women has through uncomfortable; Dysmenorrhea.The good medicine of invigorating blood circulation.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, the lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. " detailed outline " carries: Radix Salviae Miltiorrhizae, by " the sensible opinion of married woman " cloud, SIWU TANG is controlled the gynecopathy, pays no attention to antenatal puerperal, through water what, all can be general, only flavor Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.The Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves effects such as circulating, remove intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote the liver blood circulation to be beneficial to liver cell regeneration.

Pheretima: Compendium of Material Medica is referred to as to have dredge the meridian passage, blood circulation promoting and blood stasis dispelling, the effect of prophylactic treatment cardiovascular and cerebrovascular disease.Pheretima salty in the mouth cold in nature.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, logical Lip river.It is fanatical dry to cure mainly height, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, hemiplegia etc.Pheretima provides gets liquid the good effect that cloperastine is breathed heavily of deciding is arranged.

The Radix Astragali is take tonify deficiency as main, can invigorating QI to consolidate the body surface resistance, and diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of for a long time disunion.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can also be used for the generation of some infectious disease of prevention." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five ZANG-organs, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, really the gas medicine in the blood, the also panacea in the blood.About mending to mend then of assistant, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the pain relieving constipation of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so want its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Its cold in nature, salty in the mouth of Eupolyphaga Seu Steleophaga, poisonous, can enter conscience spleen three warps, has removing blood stasis, removing mass, collateral dredging, reason wound and reunion of bone, reducing swelling and alleviating pain, the stimulating milk secretion effect such as stimulate the menstrual flow, be treating blood disorders traumatology key medicine, be applicable to the diseases such as the cancer abdominal mass is gathered, amenorrhea due to stagnation of blood, postnatal blood stasis stomachache, traumatic injury, swollen and rigid tongue, congenital deformity of the tongue.Transfer the fat effect: Eupolyphaga Seu Steleophaga decocting liquid gavage; experimental hyperlipidemia Carnis Coturnicis japonicae plasma high density lipoprotein level-cholesterol and total cholesteric ratio (HDL-C/TC) can obviously raise; increase lecithin cholesterol acyltransferase (LCAT) activity, and certain atherogenesis effect that delays is arranged.

The Radix Achyranthis Bidentatae invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow; Ignite (blood) descending; Inducing diuresis for treating stranguria syndrome.Soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; Lump in the abdomen; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; The carbuncle malignant boil; Laryngopharynx swelling and pain.Medicine dispels the wind; Blood circulation and stasis-eliminating medicine.Radix Achyranthis Bidentatae has and changes hemorheology properties and anticoagulation, can reduce whole blood viscosity and the erythrocyte aggregation index of the high and low shear rate of rat, reduces packed cell volume, and the low shear rate whole blood viscosity of blood stasis model rat is also had reducing effect; To blood plasma recalcification time also significant prolongation. Inokopolyose has immunological enhancement." not Lu " carries it: the middle weak breath of curing the wound, and male kidney yin disappears, and the old man loses excessive, and invigorating middle warmer is absolutely continuous, fills out bone marrow, and except pain and pain along the spinal column in the brain, married woman's moon water is obstructed, blood agglomeration, benefit is smart, and Li Yin gas only turns white.

Semen Sinapis Albae is used for cold-phlegm breathes with cough, distending pain in the chest and hypochondrium, the expectorant meridians that stagnate, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.Give birth to warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.Stimulation: Semen Sinapis contains potassium myronate, and itself has no stimulation glycoside, generates volatile oil but meet water through the effect of myrosase, and main component is allyl isosulfocyanate, and pungent acid and stimulation are arranged.Be applied to skin, warm sensation arranged and make it rubescent, even cause blister, pustule.Usually mustard flour is used except making emplastra sinapis behind the degrease song, (dripping of irritant drugs is used in local skin as counter-stimulus, its effect is not limited only to agents area, and involve other positions, when producing therapeutical effect, be called the irritation effect), treatment neuralgia, rheumatalgia, pleuritis and sprain etc.Use first the water of tepor moistening before the use, to strengthen the effect (boiling water then suppresses the effect of myrosase) of myrosase.Applicative time is no more than 15～30 minutes, and the skin sensitivity person can only use 5～10 minutes.Mustard flour increases salivation and amylase activity as flavoring agent, and heart size and heart rate are reduced.Can stimulate in a small amount gastric mucosa to increase the secretion of gastric juice and pancreatic juice, sometimes can alleviate intractable singultus.For oral administration can cause vomiting rapidly in a large number, can be used for the treatment of narcoticness drug intoxication." Mingyi Bielu ": acrid in the mouth, temperature, nontoxic.Return nose.Main except the kidney pathogen, sharp nine orifices, improve visual and auditory acuity, regulating the spleen and stomach.Take for a long time warming middle-JIAO, Semen Sinapis Albae is again mainly penetrated the worker and chronic infectious disease gas is sent out lack perseverance place, and ball takes it; Or smash and be the end, vinegar and be coated with it is tested also conveniently.

Radix Curcumae is hot, bitter, and is cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine." book on Chinese herbal medicine just ": emesis blood, epistaxis; Alone married woman's cold air accumulation of blood of controlling, the knot gather qi together stagnates, and the trusted subordinate has a pain.

Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.Function with clearing away heat and cooling blood, eliminating stasis to stop pain.Give birth to Radix Paeoniae Rubra and win with clearing away heat and cooling blood power, the present invention uses living Radix Paeoniae Rubra exactly.Multiplex fever of the body in the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases is hemorrhage, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus.Function: clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control that the stasis of blood stagnates that amenorrhea, hernia abdominal mass gather, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.The Radix Paeoniae Rubra minute excess-heat that can purify the blood, dissipating blood stasis blood is detained.This product function and Cortex Moutan are close, so normal be usefulness with the Cortex Moutan mutual reinforcement between.But the effect of Cortex Moutan clearing away heat and cooling blood is better, and minute excess-heat that can purify the blood can be controlled fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for the blood system excess-heat, is good at promoting blood circulation to remove blood stasis.

The Cortex Cinnamomi extremely hot in nature, acrid in the mouth, sweet.That the benefit fire is supporing yang, let the fire back to its origin, dispersing cold for relieving pain, the good medicine of promoting blood circulation to restore menstrual flow.Be used for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG; Gate of vitality's fire aversion to cold and cold limbs; Soreness of the waist and knees; Impotence and seminal emission; Dysuria or frequency; The dyspnea with rapid and short breath of losing heart; The all cards of edema oliguria; Decline of the fire from the gate of life; Fire is Gui Yuan not; Floating YANG; Refusing yang; And heat in the upper and cold in the lower; The flushed complexion cold foot; Dizziness and tinnitus; Dispute is rotten broken; Spleen-kidney vacuity cold; Coldness and pain in the epigastrium; The decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain; Cold womb is infertile; The dysmenorrhea amenorrhea; The stasis of blood stagnated and suffered from abdominal pain puerperal; The carbuncle of yin nature multiple abscess; Or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus; Or do not hold back after bursting." not Lu " carries it: main pained, side of body wind, hypochondriac pain, warm muscle is promoted blood circulation, end tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago is ended saliva, cough; Can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, and nothing is feared.

The Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata minute, direct slicing is used as medicine and is Radix Polygoni Multiflori, mixes to dry to be used as medicine after the steaming with the Semen sojae atricolor liquor to be Radix Polygoni Multiflori Preparata.The function of the two is different: the detoxifcation of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation are usually used in treating scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening are used for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.

Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation.Be used for hemoptysis and spit blood traumatic hemorrhage, sore swollen toxin, chapped skin; The pulmonary tuberculosis hemoptysis, ulcer haemorrhage.1. anastalsis: it is active that Pseudobulbus Bletillae (Rhizoma Bletillae) can strengthen the platelet factor III, significantly shortens clotting time and thrombinogen formation time, suppresses the plasmin enzymatic activity, and local hemorrhage is had anastalsis; Zoopery shows, the external haemostatic effect is quite good to parenchymatous organ's (liver, spleen), muscle vascular be hemorrhage etc. for the Pseudobulbus Bletillae (Rhizoma Bletillae) water extraction.2. protection gastric mucosa: 1% Pseudobulbus Bletillae (Rhizoma Bletillae) decoct gavage, the rat pipe film injury that hydrochloric acid is caused has protective effect; Experimental Stomach duodenum perforation has therapeutical effect to anesthetized dog.3. antibiotic, antifungic action: the immersion of Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol has inhibitory action to staphylococcus aureus, bacillus subtilis, Bacillus tuberculosis; The water logging agent has inhibitory action to microsporon audouini; Contained 3 biphenyl classes and 2 the luxuriant and rich with fragrance compounds of two hydrogen of Pseudobulbus Bletillae (Rhizoma Bletillae) have inhibitory action to staphylococcus aureus, bacillus subtilis, Candida albicans ATCC 1057 and Trichophyton QM248.

Radix Et Rhizoma Rhei has another name called yellow good, fire ginseng, skin such as Wu Pu.Ancients are with its " main lower congestion, blood closes, cold and heat, broken lump in the abdomen, the prolonged fluid-retention dyspepsia is cleansed the intestines and stomach, pushes away Chen Zhixin, tonneau water paddy, relieving dyspepsia in the accent, peace and the five internal organs ".Radix Et Rhizoma Rhei is used for the treatment of burn, scalds at China's long history." book on Chinese herbal medicine cover mirror " record: " the yin aspect of yin was coagulated the soup clearly if grind chicken into powder, can apply burn and get effect Radix Et Rhizoma Rhei bitter in the mouth, gas Great Cold."; " medicine mirror " record: " large yellow maturity does not close up for a long time with then controlling all fire-toxin skin ulcers.Lid all belongs to fire-toxin with all malicious burn, and large yellow maturity usefulness then can be let out fire-toxin, and reducing swelling and alleviating pain." Compendium of Material Medica grass section the 17 volume Radix Et Rhizoma Rhei cures mainly lower record " Radix Et Rhizoma Rhei is controlled all burn."; Theory of Chinese medical science thinks that burn and scald is that fire-toxin is trouble, local coagulation of QI-blood, and meridians block, and putrefaction of blood and muscle forms, and Radix Et Rhizoma Rhei has the pathogenic fire purging of capturing, heat clearing away treating narcotic addiction, the key medicine that the removing heat from blood clots absorbing is the treatment burn, scald.Modern medicine also prove Radix Et Rhizoma Rhei have invigorate blood circulation, hemostasis, antibacterial, eliminate endotoxin, improve immunity of organisms, reduce the effects such as body temperature, analgesia.Radix Et Rhizoma Rhei contains anthraquinone, anthraquinone derivatives is stronger to staphylococcus, streptococcus antibacterial action; Tannin contained in the Radix Et Rhizoma Rhei has good astriction to wound surface, can promote the wound face healing.

Radix Sanguisorbae property of medicine picric acid; Cold; Nontoxic, return liver; Lung; Kidney; Large intestine channel, effect cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Effect classification hemorrhage; Blood-cooling hemostatic.Cure mainly haematemesis, spitting of blood, epistaxis, hematuria is had blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting." detailed outline ": Radix Sanguisorbae, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat, control the defecation blood disorder.Hemostasis is got and is cut off sheet and fry usefulness, and its tip then can promoting the circulation of blood, can not know.The Yang Shiying cloud: all skin ulcer pain persons add Radix Sanguisorbae, and the person of itching adds Radix Scutellariae.

Radix Sanguisorbae preparata: Radix Sanguisorbae dried be ground into superfine powder, sieve; Boil with Oleum Sesami (or vegetable oil) in addition, then rapid elm powder intensively stirs and makes into pasty state, and it is interior for subsequent use to be contained in sterile pot.Time spent directly is applied to wound surface with mass, can very fast formation 1 thick layer medicine crust, can play prevention and infection control, and eliminate pain promotes the effects such as wound surface heals rapidly.Generally be applicable to one, second degree burn, scalded patient.Radix Sanguisorbae contains a large amount of tannins, and stronger convergence and pressor effect are arranged, and can reduce the permeability of blood vessel, reduces inflammatory exudation, also has simultaneously obvious bactericidal action, can resist charrin's disease.Also can adopt Radix Sanguisorbae ethanol liquid (Radix Sanguisorbae is cleaned and to dry, and grinds coarser powder and extracts clear liquid with 70～75% ethanol percolation, boils to liquid level thin film to occur, cools off for subsequent use) to be coated with burn wound, every day 2～3 times, not wrap up.The coating number of times forms dry crusts and be full of cracks do not occur as degree take wound surface.To the wound surface that has the polluted debridement treatment of to go ahead of the rest.By one, the observation of second degree burn patient 40 examples; prove this method to superficial burns, special centering small size, to pollute lighter burn effect better, generally can form 1 layer of brown protecting film on the wound surface through 12～24 hours; this oozes out preventing germ contamination, minimizing wound surface, and good impact is all arranged.

The Cortex Phellodendri heat clearing and damp drying, pathogenic fire purging is except steaming, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The Cortex Phellodendri nourishing YIN to lower pathogenic fire.Be used for hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency." Chinese pharmacopoeia is carried the power of Cortex Phellodendri heat clearing and damp drying, and is similar to Radix Scutellariae, Rhizoma Coptidis, but damp and hot as good take except the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.

The Myrrha blood blood stasis removing that falls apart, subduing swelling and relieving pain.Control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Hardship, suffering, flat.1. " property of medicine opinion ": " bitter in the mouth is hot." 2. " Haiyao Bencao, Oversea Materia Medica ": " bitter in the mouth is hot, and temperature is nontoxic." 3. " Kaibao Bencao ": " and bitter in the mouth, flat, nontoxic." enter liver, spleen, the heart, kidney channel.1. " Bencao Jingshu ": " enter meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine is newly organized ": " enter spleen, kidney two warps." 3. " book on Chinese herbal medicine is looked for the truth ": " enter the heart, liver." join Olibanum, promoting blood circulation to remove blood stasis, circulation of qi promoting Shujin; Wear Squama Manis, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.Match exhausts, promoting blood circulation to remove blood stasis, pain relieving.Join Realgar, detumescence and promoting granulation, dampness detoxifcation.

Olibanum is arduous, temperature.Regulating qi and activating blood, analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge." not Lu ": it be swollen to treat the edema due to wind pathogen poison, removes bad odor.Treat the urticaria poison of itching.Supplement to the Herbal: treat deaf, the apoplexy locked mouth, married woman's vim and vigour can be sent out wine, manage air-cooledly, only large intestine is let out Bleach, treats all skin ulcers and makes internal diabetes.Control to fall and pounce on the folding wound.

The Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Tradition thinks that Radix Clematidis has wind-damp dispelling, the meridian dredging, the bone that disappears three large effects of choking, because its property is walked to alter, the pharmacology confirms that it removes esophagus in addition, bronchus, ureter, stomach and biliary tract etc. are located the effect of smooth muscle spasm, and stronger anti-inflammatory analgetic effect arranged, hypoglycemic activity Radix Clematidis preserved material to normal rat have the assimilation of remarkable enhancing glucose effect (namely give rat with a large amount of glucoses after, the glucose in urine test is still negative), therefore hypoglycemic activity may be arranged. in vitro, the water logging agent has inhibitory action to dermatophytes. and the water logging agent also has inhibitory action to microsporon audouini; Decoct has inhibitory action to staphylococcus aureus, shigella. and the decoct lumbar injection can slightly improve the mice threshold of pain, points out it that analgesic activity is arranged. and decoct has inhibitory action to plasmodium. and alcohol extract has the induced labor effect to the mice midtrimester of pregnancy.

Herba Asari cures mainly: dispels the wind, and cold expelling, row water is had one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.Warm in nature, acrid in the mouth, function dispelling cold by warming the meridian, dissipating fluid-retention, wind-expelling pain-stopping cure mainly the diseases such as headche due to wind-cold, phlegm retention cough with asthma, rheumatic arthralgia, toothache, nasal sinusitis.Antiinflammatory, immunosuppressant and antiallergic action Herba Asari volatile oil gavage or inject all obvious antiinflammatory action.Such as Herba Asari the rat arthroncus due to proinflammatory agent carrageenin, yeast, Ovum Gallus domesticus album, the formaldehyde etc. there is obvious inhibitory action, and can resist Oleum Tiglii induced mice auricle edema, the rat skin edema that the inhibition antiserum causes, the capillary permeability that is caused by histamine increase and inhibition plastic hoop and cotton balls granulation hyperplasia.Rat to adrenalectomy still has antiinflammatory action.

The sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Be rare Chinese medicine, but give birth to hemostasia and dissipation blood stasis, reducing swelling and alleviating pain to have good hemostasia effect, significant hemopoietic function; Can tighten and improve Coronary microcirculation, Radix Notoginseng is used as medicine with a long history, acts on peculiarly being considered as treasured in the medicine by ancient Chinese medicine doctor, so the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) " is arranged." it is little sweet and bitter to distinguish the flavor of, quite seemingly the flavor of Radix Ginseng for Radix Notoginseng." " all canes are pounced on trauma, and the dripping person of blood stasis chews namely ending of mashed net for catching birds or fish immediately, and bruise the person namely dissipate.If when being subjected to cane, take first one, two money, then the blood centre of punch not should take it behind the cane especially, and puerperal, clothes were also good.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of the cloudy blood system of fainting, so can control all disorders of blood "." book on Chinese herbal medicine is looked for the truth " record: " Radix Notoginseng, common people only know the function hemostasis and pain-relieving.Hardly realize bitterly and ache work because of blood stasis that blood ends because applying loose blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient can be in its blood stasis of blood systemization.”

The dried Alumen expectorant, dampness, antidiarrheal, hemostasis, detoxifcation, parasite killing.Control epilepsy, sore throat, remorse saliva is stopped up very, hepatitis, jaundice, general edema with yellowish skin, Stomach duodenum ulcer, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies, water, fire, insect bite." detailed outline ": " tell lower sputum drink phosphorus, the dampness detoxifcation chases after saliva, the hemostasis analgesic therapy, meat is disliked in erosion, gives birth to good meat, and it is swollen to control the carbuncle furuncle, malignant boil, epilepsy, subcutaneous ulcer disease, relieving bowels, all diseases of ability to speak eyes, brave dog snakes and scorpions hundred insect bites."

Fructus Cnidii is hot, bitter, temperature; Slightly poisonous.Return kidney channel.Cure mainly warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.Be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; The external treatment vulval eczema, married woman's pudendal pruritus; Senile vaginitis is gynecological external use good medicine." Bencao Jingshu " carries: Fructus Cnidii, and bitter in the mouth is flat; " not Lu " be hot sweet nontoxic; Modern detailed its abnormal smells from the patient, when the warm-dryness syndrome of must holding concurrently, sun also.So swell and ache in housewife people's the moon, man's impotence pruritus due to damp pathogen, except stagnated QI, sharp joint, malignant boil." not Lu " warming the middle warmer and descending qi makes married woman's Zifu heat, and the man is cloudy strong, has made us son.Lid can dehumidify with tongue, temperature energy cold expelling, and suffering can be moistened kidney, and so sweet energy strengthening the spleen is can be except the wet disease of viscera connecting with this channel of all deficiency and coldness of married woman man.Cold-damp was both removed, and then disease is gone, performance Yiyang, thus disease, and have tonification also.

Rhizoma Drynariae is bitter, temperature.Return kidney, Liver Channel.Function the kidney invigorating bone strengthening continues and hinders pain relieving.Be used for lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, the muscle fracture wound; The external treatment alopecia areata, vitiligo." Japan hanako materia medica " carries it: control malignant boil, the mashed meat of erosion, parasite killing.The good medicine that surgery is used to remove the skin toxin.

The manufacturing process of pill of the present invention is: get Rhizoma Corydalis 1000g, Radix Rehmanniae Preparata 1200g, Radix Angelicae Sinensis 1300g, Radix Astragali 1400g, Radix Achyranthis Bidentatae 1300g, Radix Salviae Miltiorrhizae 1500g, Radix Polygoni Multiflori Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1400g, Poria 1300g, Radix Curcumae 1500g, Flos Carthami 1300g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1100g, Pheretima 1400g, Herba Dendrobii 1200g, Eupolyphaga Seu Steleophaga 1300g, Cortex Cinnamomi 1200g, Semen Sinapis Albae 1100g, Radix Paeoniae Rubra 1200g, first with raw medicinal material with 75% soak with ethanol 12-24 hour, heat is extracted three times, filters, filtrate merges and Recycled ethanol, be condensed into thick paste, drying under reduced pressure below 70 ℃ is ground into fine powder; Ethanol refined medicinal residues, decocted with water 1 time, and the time is 30 minutes-1 hour, and decocting liquid filters, and filtrate is condensed into thick paste, and drying is ground into fine powder; Twice the fine powder that obtains is mixed, be twisted into pill.

The manufacturing process of capsule of the present invention is: raw medicinal material Rhizoma Corydalis 1400g, Radix Rehmanniae Preparata 1500g, Radix Angelicae Sinensis 1300g, Radix Astragali 1400g, Radix Achyranthis Bidentatae 1300g, Radix Salviae Miltiorrhizae 1500g, Radix Polygoni Multiflori Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1400g, Poria 1300g, Radix Curcumae 1500g, Flos Carthami 1300g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1100g, Pheretima 1200g, Herba Dendrobii 1200g, Eupolyphaga Seu Steleophaga 1200g, Cortex Cinnamomi 1100g, Semen Sinapis Albae 1500g, Radix Paeoniae Rubra 1300g mixes raw medicinal material with the pulverizer pulverizing by described ratio of weight and number, then crosses 120 mesh sieves, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, and collecting fine powder by 120 mesh sieves, to get fine powder for subsequent use; Can not drop into multi-function extractor by the coarse powder of 120 mesh sieves again and extract twice, and add 8-10 for the first time and doubly measured ethanol extraction 1-2 hour, and add 4-8 for the second time and doubly measured ethanol extraction 1-2 hour, merge extracted twice liquid, filter to get filtrate; Heating is concentrated into pasty state, cools off after putting into 80 ℃ of oven dry of baking oven, grinds to form fine powder; Twice the fine powder that obtains is mixed, incapsulate behind the ultraviolet disinfection.

Method for preparing tablet thereof of the present invention: get raw medicinal material Rhizoma Corydalis 1300g, Radix Rehmanniae Preparata 1400g, Radix Angelicae Sinensis 1500g, Radix Astragali 1400g, Radix Achyranthis Bidentatae 1300g, Radix Salviae Miltiorrhizae 1500g, Radix Polygoni Multiflori Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1400g, Poria 1300g, Radix Curcumae 1500g, Flos Carthami 1200g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1100g, Pheretima 1300g, Herba Dendrobii 1100g, Eupolyphaga Seu Steleophaga 1200g, Cortex Cinnamomi 1100g, Semen Sinapis Albae 1100g, Radix Paeoniae Rubra 1500g puts into into twice of multi-function extractor extraction by described ratio of weight and number, for the first time adding 8-10 doubly measured ethanol extraction 1-2 hour, for the second time add 4-8 and doubly measured ethanol extraction 1-2 hour, merge extracted twice liquid, filter to get filtrate; Heating is concentrated into pasty state, cools off after putting into 80 ℃ of oven dry of baking oven, grinds to form fine powder; The medicinal residues that ethanol refined are put into 5-10 times of water gaging heating extraction twice, each 1-2 hour, merge extractive liquid, filters, and is concentrated, the 80-160 order filters, the 6000-10000 rev/min of supernatant after centrifugal is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.35 extractum when ultrafiltrate concentrating under reduced pressure relative density is 60 ℃, the concentrated oven dry of heating becomes fine powder; Twice fine powder is mixed, and ultraviolet disinfection adds the starch tabletting.

The preparation method of granule of the present invention: a. is with described crude drug raw medicinal material Rhizoma Corydalis 1200g, Radix Rehmanniae Preparata 1500g, Radix Angelicae Sinensis 1500g, Radix Astragali 1400g, Radix Achyranthis Bidentatae 1300g, Radix Salviae Miltiorrhizae 1500g, Radix Polygoni Multiflori Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1400g, Poria 1400g, Radix Curcumae 1200g, Flos Carthami 1500g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1100g, Pheretima 1300g, Herba Dendrobii 1100g, Eupolyphaga Seu Steleophaga 1300g, Cortex Cinnamomi 1500g, Semen Sinapis Albae 1400g, Radix Paeoniae Rubra 1200g put into and cross 100-120 order dusting cover after pulverizer is pulverized, the fine powder amount that enable pass is crossed sieve aperture is reaching 30%-40%, collects by the raw material fine powder of sieve aperture for subsequent use.Put into the pulverizer grinding and sieving; The rear remaining particulate matter that sieves is put into 10 times of amount 75% ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Above-mentioned extracted twice liquid is merged, 1.35 filtrate when the concentrating under reduced pressure relative density is 80 ℃, Recycled ethanol is adjusted proportion to 1.06 with gained filtrate, passes into spray dryer and carries out spray drying, and the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m ², the hothouse hot stream temperature is 80 ℃-100 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving is mixed in the bag of packing into raw material medicated powder.

Medicine for external use agent type is powder in the Chinese medicine composition, and its preparation method comprises: first with Herba Asari 1800g and Radix Notoginseng 2000g water steam extraction method, make crystallization according to described portion rate; With all the other described component Radix Clematidis 1900g, Olibanum 2300g, Myrrha 2100g, Radix Et Rhizoma Rhei 1800g, Cortex Phellodendri 1700g, Rhizoma Smilacis Glabrae 1900g, Radix Sanguisorbae preparata 2100g, Flos Carthami 1700g, Fructus Cnidii 1600g, Pseudobulbus Bletillae (Rhizoma Bletillae) 2100g, Rhizoma Drynariae 2100g mixes by proportioning, drops into pulverizer and is ground into fine powder, puts into the acid and alkali-resistance infusion kettle after fine powder sieves, decocted 1-2 hour, and filtered; Filtering residue adds water and decocted 1-2 hour again, filters; Mix extracted twice liquid, carry out squeeze and filter, get filtrate after the separation, extracted twice liquid concentrate drying is become powder, mix the crystal that distillation obtains, even with mixing after the dried Alumen 2100g pulverizing again, behind ultraviolet radiation for sterilizing and disinfecting, make powder.

The preparation method of external gauze of the present invention agent: with described crude drug Radix Clematidis 2100g, Olibanum 2300g, Myrrha 2100g, Radix Et Rhizoma Rhei 1800g, Cortex Phellodendri 1700g, Rhizoma Smilacis Glabrae 1900g, Radix Sanguisorbae preparata 2100g, Flos Carthami 1700g, Fructus Cnidii 1900g, Pseudobulbus Bletillae (Rhizoma Bletillae) 2500g, Rhizoma Drynariae 2000g, Radix Notoginseng 2100g, Herba Asari 2300g, dried Alumen 2400g grinds to the powder altogether, crosses the l20 mesh sieve, and coarse powder adds ethanol extraction once, be condensed into powder, two kinds of powder mixing add 70% vaseline accent and all are applied to aseptic dried sliver, put in the container, and are for subsequent use after the high pressure steam sterilization sterilization; Wound surface is changed dressings: behind the slough through thoroughly remove ulcer wound surface with surgical method l of the present invention～2 a layer sliver spread on the wound surface, do not contact normal skin, the external use sterile gauze piece covers.

Using method is: first the skin ulcer face is cleaned with 3% hydrogen peroxide first, wipe out slough, clean with normal saline, then peripheral skin 75% alcohol disinfecting mixes the present invention breaking into fine powder again, be dispersed in equably on the skin ulcer face, to cover and to surpass whole skin ulcer faces to surrounding normal skin, cover again 2～3 layers of sterile gauze, fix with Breathable adhesive tape, change dressings 1 day 1 time, treating 20 days is 1 course for the treatment of.

The dosage form of external is that the preparation method of ointment comprises: with described crude drug Radix Clematidis 2100g, Olibanum 2300g, Myrrha 2100g, Radix Et Rhizoma Rhei 1800g, Cortex Phellodendri 1700g, Rhizoma Smilacis Glabrae 1900g, Radix Sanguisorbae preparata 2100g, Flos Carthami 1700g, Fructus Cnidii 1900g, Pseudobulbus Bletillae (Rhizoma Bletillae) 2500g, Rhizoma Drynariae 2000g, Radix Notoginseng 2100g, Herba Asari 2300g adds soak with ethanol 1-2 hour, and heating was boiled 30～40 minutes, filter filtrate for later use; Filtering residue adds ethanol and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 40～50 minutes for the third time, filters; Merge three times extracting solution, be concentrated into relative density and be 1.08 concentrated solution; Filter, left standstill 24 hours, after remove supernatant, get concentrated medicament; Dried Alumen 2500g is broken into fine powder, drop in the concentrated medicament, mediation 70%-80% vaseline, tinning.

The experiment of endo-medicine pharmacology pharmacodynamic:

1 materials and methods

1.1 experiment material

1.1.1 laboratory animal: 90 male SD rats, cleaning level, 3 monthly ages, weight 200～250g, medical college laboratory animal raising chamber provides by Shandong, and the animal quality certification number is No. the 0222222nd, the moving word of doctor.

1.1.2 Experimental agents decoction of the present invention: the side uses: Rhizoma Corydalis 10g, Radix Rehmanniae Preparata 15g, Radix Angelicae Sinensis 12g, Radix Astragali 10g, Radix Achyranthis Bidentatae 11g, Radix Salviae Miltiorrhizae 12g, Radix Polygoni Multiflori Preparata 11g, Rhizoma Atractylodis Macrocephalae 15g, Poria 13g, Radix Curcumae 10g, Flos Carthami 12g, Rhizoma Chuanxiong 11g, Caulis Spatholobi 10g, Pheretima 11g, Herba Dendrobii 12g, Eupolyphaga Seu Steleophaga 11g, Cortex Cinnamomi 13g, Semen Sinapis Albae 10g, Radix Paeoniae Rubra 11g.Decoction of four noble drugs (" formulary of peaceful benevolent dispensary ") is comprised of Radix Codonopsis 9g, Rhizoma Atractylodis Macrocephalae 9g, Poria 9g, Radix Glycyrrhizae 6g, and being evaporated to concentration is 0.36g/ml, and the rat dosage is crude drug 2.90g/ (kgd).SIWU TANG (" formulary of peaceful benevolent dispensary ") is comprised of Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 9g, Radix Paeoniae Alba 9g, Rhizoma Chuanxiong 6g, and being evaporated to concentration is 0.40g/ml, and the rat dosage is crude drug 3.17g/ (kgd).BAZHEN TANG (" the roman class is wanted ") is comprised of Radix Codonopsis 9g, Rhizoma Atractylodis Macrocephalae 9g, Poria 9g, Radix Glycyrrhizae 6g, Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 9g, Radix Paeoniae Alba 9g, Rhizoma Chuanxiong 6g, being evaporated to concentration is 0.76g/ml, and the rat dosage is crude drug 6.07g/ (kgd).

Above Chinese medicine is pressed the preparation of water decoction-alcohol sedimentation technique by the Drug Manufacturing Room of Hospital Attached to Shandong Chinese Medical Univ., and 4 ℃ of Refrigerator stores are for subsequent use.

1.1.3 main experiment reagent immunohistochemistry streptomycete avidin 2 peroxidase connection methods (st reptavidin2biotinperoxidase met hod, SP) test kit is available from U.S. Zymed company; Instant EnVision reagent is available from Denmark Dako company; VEGF (vascular endot helial growt hfactor, VEGF) primary antibodie (the anti-Mus of rabbit, respectively dilution in 1: 100,1: 50) is available from U.S. Santa Cruz company; Biotin labeled goat anti-rabbit immunoglobulin G (immunoglobulin G, IgG) is available from German Vector company; Horseradish peroxidase (horseradishperoxidase, HRP) labelling goat anti-mouse antibody is available from Beijing Zhong Shan company; Injection hydrocortisone sodium succinate (50mg/ props up) is available from the Tianjin Biochemical Pharmaceutical Factory.

1.1.4 main experimental apparatus IMS cytological image analyses system and medical image analysis software are available from Shen, Shanghai rattan Information Technology Co., Ltd; Video camera (model: MV2CP410), available from Panasonic company; Optical microscope is available from Olymp us company; B H2 digital camera is available from Nikon company.

1.2 experimental technique

1.2.1 the foundation of chronic wound rat model

Rat is after conventional 1 week of raising, ketalar (100mg/kg) intraperitoneal injection of anesthesia, molding bay (lumbar vertebra hits exactly on the upper side) cropping, with the plastic bottle closure of diameter 20mm at molding bay labelling modeling area, under aseptic condition, make two dark wound surface that reach fascia along the vertebra direction with surgical method, set up the open wound model of full thickness dermal.Except Normal group, intramuscular injection hydrocortisone acetate (80mg/kg weight) at once after the rat modeling is made the refractory wound surface model.Wound surface is added a cover two-layer sterilization dry gauze, fixes with adhesive plaster " rich " font.Every the continuous 4d hindlimb muscle injection of rat penicillin 400,000 U after the modeling are with prevention infection.

1.2.2 the laboratory animal grouping divides 2 batches to test with 90 rats of medication.The 1st batch of 40 rats are mainly used in observing medicine to the impact of wound healing time.40 rats extract first 8 and are Normal group, and the wound surface manufacture method is the same, and all the other 32 rats are set up model of chronic wound.Be divided at random again model group (8), decoction of four noble drugs group (8), SIWU TANG group (8), BAZHEN TANG group (8) behind the Cheng Mo.The 2nd batch of 50 rats are mainly used in inquiring into the mechanism of the short wound healing of medicine.50 rats extract first 10 and are Normal group, and the wound surface manufacture method is the same, and all the other 40 rats are set up model of chronic wound.Be divided at random again model group (10), decoction of four noble drugs group (10), SIWU TANG group (10), BAZHEN TANG group (10) behind the Cheng Mo.Each organizes beginning administration in the 2nd day after modeling, and it is front all with 1/5000 furacilin solution cleaning wound surface to change dressings.Normal group and model group external application monolayer normal saline gauze, normal saline gavage, 1 time/d; Decoction of four noble drugs group, SIWU TANG group and BAZHEN TANG group external application monolayer normal saline gauze give corresponding Chinese medicine gavage, and 1 time/d, continuous use 7d.After the drug withdrawal the 2nd day, respectively the animal Patients Under Ketamine Anesthesia is put to death, get local woanded surface new granulation tissue and detect.1.2.3 the observation of wound healing time is observed 40 rats and is played the complete epithelization required time of wound surface from topical agent.

1.2.4VEGF and the detection of microvessel count

1.2.4.1 Use immunohistochemistrySP SP detects vegf expression

Get and respectively organize rat wound surface new granulation tissue, after normal saline cleaned, 10% formalin was fixed.Choose at random 8 samples for every group, with the fixing respectively conventional dehydration of each granulation tissue specimen, waxdip, embedding, serial section.Get 4 μ m paraffin sections, the conventional dewaxing of dimethylbenzene, gradient alcohol dehydration, PBS washing, 3min * 3 time; 3%H2O2 room temperature 20min, PBS washing, 3min * 3 time; To cut into slices and immerse in 0.01mol/Lp H 6.0 citrate buffers, antigen retrieval time is carried out in microwave oven III shelves (98 ℃) 10min * 2, natural cooling at room temperature after the taking-up; Drip 10% normal serum sealing endogenous heterogenetic antigen, room temperature 30min; Drip VEGF primary antibodie (being respectively above-mentioned antibody and corresponding antibodies dilution factor), 4 ℃ of refrigerator overnight; PBS washing, 3min * 3 time drip 200,37 ℃ of 30min of biotinylation goat anti-rabbit igg 1 ︰, PBS washing, 3min * 3 time; 20037 ℃ of 30min of St reptavidin2HRP 1 ︰, PBS washing, 3min * 3 time, the 0.05%DAB+0.03%H2O2 8～12min that develops the color, flowing water is washed; The haematoxylin lining dyes, and flowing water is washed; Dry up conventional resin mounting.

Detection brown color occurs with endochylema or the brown granular person is judged to be positive cell, replaces primary antibodie as negative control with the PBS buffer.

1.2.4.2 image analytical method is analyzed vegf expression amount and microvessel count

Adopt MV2CP410 video camera, IMS cytological image analyses system, by microscope, image pick-up card, digital camera or ccd video camera capturing digital image, digital picture is BMP (bitmap) file format of standard; Under 100 times of optical microscopes, click first two points on the little chi of image, with its actual micron number input computer, storage was for subsequent use after computer calculated scale factor automatically again; Eliminate the hyacinthine background in the SABC image, select negative zone, represent with blueness after processing; Select brown color or sepia positive region, represent with redness after processing; Measure positive region area and positive ratio and optical density value in the image, 3 visuals field are chosen in every section at random, obtain the meansigma methods in 3 visuals field, calculate the vegf expression level.Every paraffin section is chosen 3 visuals field in granulation tissue zone at random, obtains the meansigma methods in 3 visuals field, counts microvascular number (microvessel count, MVC).

1.3 statistical method

Adopt SPSS 11.5 softwares to carry out data analysis, continuous data represents with x ± s, carries out the t check or whether a plurality of sample one factor analysis of variance (q check) comparison group difference has statistical significance.

2 results

2.1 the benefiting vital QI and blood prescription is on the impact of chronic wound healing time

Model group wound healing time compared with normal matched group obviously prolongs (P＜0.01); Compare with model group, decoction of four noble drugs group, BAZHEN TANG group and SIWU TANG are formed the face healing time and are obviously shortened (P＜0.01, P＜0.05); Decoction of four noble drugs is formed face healing time and Normal group comparing difference not statistically significant (P〉0.05), and SIWU TANG group and BAZHEN TANG are formed the face healing time and obviously be longer than Normal group (P＜0.05); Compare with the decoction of four noble drugs group, SIWU TANG group and BAZHEN TANG are formed the face healing time and are prolonged (P＜0.05); SIWU TANG group and BAZHEN TANG are formed the face healing time relatively, the difference not statistically significant (P〉0.05).See Table 1.

Table 1 is respectively formed the face healing time relatively

P<0.05,﹡﹡P<0.01,△P<0.05,△△P<0.01,;▲P<0.05,

2.2 the benefiting vital QI and blood prescription is on the impact of chronic wound granulation tissue vegf expression

The expression of model group VEGF is starkly lower than Normal group (P＜0.01); Decoction of four noble drugs group, SIWU TANG group and BAZHEN TANG group vegf expression be apparently higher than model group (P＜0.01, P＜0.05), but all be lower than Normal group (P＜0.01).SIWU TANG group and BAZHEN TANG group vegf expression are lower than decoction of four noble drugs group (P＜0.05).SIWU TANG group and BAZHEN TANG group compare, vegf expression difference not statistically significant (P〉0.05).See Table 2.

2.3 the benefiting vital QI and blood prescription is on the impact of chronic wound granulation tissue MVC

Model group MVC is starkly lower than Normal group (P＜0.01); Each treatment group MVC is apparently higher than model control group (P＜0.01), but all is lower than Normal group (P＜0.01).SIWU TANG group and BAZHEN TANG group MVC all are starkly lower than decoction of four noble drugs group (P＜0.01).SIWU TANG group MVC and BAZHEN TANG group compare, the difference not statistically significant (P〉0.05).See Table 2.

Table 2 is respectively formed face granulation tissue vegf expression and MVC

P<0.05,﹡﹡P<0.01,;△P<0.05,△△P<0.01,;▲P<0.05,▲▲P<0.01.

The external used medicine pharmacodynamic experiment

Its impact on the healing of rat refractory wound surface of this laboratory observation.

1 materials and methods

1.1 animal: 40 of cleaning level SD rats, male, weight 200-250g, average (220.32 ± 10.10) g (being provided by biology department of Shandong University breeding center).

1.2 medicine: vaseline, necrosis removing and granulation promoting plaster, external pulvis of the present invention.

1.3 reagent and instrument: ketaject injection (every 011g/2mL, Hengrui Medicine Co., Ltd., Jiangsu Prov. produces, lot number: KH051001); Hydrocortisone sodium succinate (every 50mg/2mL, the Tianjin Biochemical Pharmaceutical Factory produces, lot number: 20010419,20060104); (800,000 U/ prop up benzylpenicillin sodium for injection, and Huabei Pharmaceutic Co., Ltd produces, lot number: Y0511222).Electrocardiograph paper (specification 50mm * 30m, Shanghai three or five paper plant's company limiteies are produced).

1.4 modeling method: the full thickness dermal method is made the animal body surface Ulcer Models.Rat is divided into 5 groups at random: general wound surface group, model control group, vaseline group, necrosis removing and granulation promoting plaster group, unguentum group of the present invention, 8 every group.After rats by intraperitoneal injection ketalar (100mg/kg body weight) anesthesia, molding bay (lumbar vertebra hits exactly on the upper side) is shaved hair, with diameter 2cm plastic bottle closure at molding bay labelling modeling area, benzalkonium bromide tincture cotton balls skin degerming, cut off subcutaneous tissue to muscular fasciae along mark line, hemostasis, antiseptic gauze dressing covers wound, forms the open wound model of rat full thickness dermal (general wound surface).Except general wound surface group, remaining 4 groups of intramuscular injection hydrocortisone sodium succinates (8mg/100g body weight) at once after modeling, make the refractory wound surface model, injected continuously 5 days.Operation rose the same day, every group of equal intramuscular injection penicillin sodium salt (4000U/ is only), for three days on end, in case infect.

1.5 medication

Each organizes in modeling and begins to change dressings next day, and every day 1 time, it is front all with 1/5000 nitrofural clean wound to change dressings, and general wound surface group and model control group all cover with the normal saline gauze; All the other each groups are used respectively vaseline, external pulvis of the present invention, and necrosis removing and granulation promoting plaster spreads on wound surface, and the external sterile gauze covers, and medical proof fabric is fixed, and changes dressings until all wound surface all heal.

1.6 observation index

1.6.1 Wound healing rate: after modeling the 5th, 7,10 day, use the hyaline membrane flap coverage, mark stroke film covers hyaline membrane and calculates the wound surface area on the electrocardiograph paper.Calculate Wound healing rate by following formula: healing rate=(original wound surface area-the wound surface area does not heal)/original wound surface area * 100%.

1.6.2 wound healing time: record plays the complete epithelization required time of wound surface from topical agent.

1.7 statistical method

Adopt SPSS 11.0 softwares to carry out data analysis.Continuous data represents with mean ± standard deviation, carries out relatively group difference of a plurality of sample one factor analysis of variance.

2 results

2.1 the impact on Wound healing rate

The model control group Wound healing rate all was lower than general wound surface group (P＜0.05) in the 5th day, the 7th day, the 10th day, showed the modeling success.The 5th day, each intervention group Wound healing rate was compared no significant difference (P〉0.05) with model control group; The 7th day, vaseline group, necrosis removing and granulation promoting plaster group healing rate all were higher than model control group (P＜0.05); The 10th day, powder group healing rate of the present invention was apparently higher than vaseline group, necrosis removing and granulation promoting plaster group (P＜0.01).See Table 1.

Table 1 respectively organize the different time points Wound healing rate relatively (%, ^-X ± s)

Compare ， ﹡ P＜0.05 with general wound surface group; Compare △ P＜0.05, △ △ P＜0.01 with model control group.

2.2 the impact on wound healing time

Model control group wound healing time compared with normal wound surface group obviously prolongs (P＜0.01); Compare with model control group, powder group healing time of the present invention shortens (P＜0.01).See Table 2.

Table 2 respectively form the face healing time relatively (d, ^-X ± s)

Compare ， ﹡ ﹡ P＜0.01 with general wound surface group; Compare △ △ P＜0.01 with model control group.

Clinical pharmacodynamics:

1.1 clinical data is chosen my institute endocrine patient 40 examples of being in hospital May 1 year March in 2007, is divided at random two groups.Treatment group 20 examples, male's 13 examples, women's 7 examples; Year mean age (62.37 ± 9.13); Average 8.4 years of diabetic duration; The average 28.5d of the diabetic foot course of disease; Wound surface average area 2.54cmX 3.34cm; Fasting glucose (12.22 ± 6.41) mmol/L; Glycolated hemoglobin (11.004-2.25) %; Body Mass Index (22.76 ± 3.12).Matched group 20 examples, male's 12 examples, women's 8 examples, year mean age (64.22 ± 6.21); Diabetes average course of disease 11.1; The average 27.3d of the diabetic foot course of disease; Wound surface average area 2.75cm * 3.24cm; Fasting glucose (11.2 ± 6.41) mmo1/L; Glycolated hemoglobin (8.84 ± 2.24) %; Body Mass Index (21.76 ± 2.61).Wagner Grading treatment group is 1 grade of 7 example, 2 grade of 8 example, 3 grade of 5 example; Matched group is 1 grade of 5 example, 2 grades of l0 examples, 3 grade of 5 example.Two groups of data difference not statistically significants (P〉0.05), have comparability.

1.2 the diagnostic criteria Western medicine diagnose is with reference to the diagnostic criteria of diabetic foot cooperative groups, and carries out classification by Wagner grade scale in 1981.

1.3 Therapeutic Method (1) systemic administration: treatment group prescription of the present invention: the side uses: Rhizoma Corydalis 10g, Radix Rehmanniae Preparata 15g, Radix Angelicae Sinensis 12g, Radix Astragali 10g, Radix Achyranthis Bidentatae 11g, Radix Salviae Miltiorrhizae 12g, Radix Polygoni Multiflori Preparata 11g, Rhizoma Atractylodis Macrocephalae 15g, Poria 13g, Radix Curcumae 10g, Flos Carthami 12g, Rhizoma Chuanxiong 11g, Caulis Spatholobi 10g, Pheretima 11g, Herba Dendrobii 12g, Eupolyphaga Seu Steleophaga 11g, Cortex Cinnamomi 13g, Semen Sinapis Albae 10g, Radix Paeoniae Rubra 11g, matched group adopts the subcutaneous injection of insulin blood sugar lowering, infection control, cultivation of cervical secretions is got in the part, carries out antibiotic therapy, adopt the depression of order ladder type to select antibiotic, whole body gives ligustrazine, prostaglandin E, the blood circulation promoting and blood stasis dispelling such as vancomin, expander, the symptomatic treatment J such as trophic nerve.(2) local application: actively remove the tissue, fascia, tendon, broken bone of wound surface necrosis, withered toes or toe-end, clean with povidone iodine and normal saline.Treatment group external preparation of the present invention, the side uses: Herba Asari 20g, Radix Clematidis 18g, Radix Notoginseng 15g, Olibanum 17g, Myrrha 17g, Radix Et Rhizoma Rhei 19g, Cortex Phellodendri 15g, dried Alumen 20g, Rhizoma Smilacis Glabrae 15g, Radix Sanguisorbae preparata 19g, Flos Carthami 20g, Fructus Cnidii 17g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Rhizoma Drynariae 15g makes powder.Powder spreads on instep, and meche spreads on wound surface, and sinus tract also will be clogged, and the aseptic adjuvant wrapping of external application adopts the method for nibbling to remove gradually slough, and 3d changes dressings 1 time; Matched group gives ethacridine gauze soak wound surface, then removes gradually slough, and the debridement process continues with the soak of ethacridine gauze, and with gentamycin, 654-2 medicinal liquid soaks, the aseptic adjuvant of external application, 3d were changed dressings 1 time after fresh granulation tissue exposed.Two groups all take 25d as 1 course for the treatment of.

1.4 observation index is observed the secretions situation of wound surface, the newborn situation of the granulation of local woanded surface after the medication, the speed of growth, fascia are repaired situation, and variation, growth or the disappearance situation of bacterial species are observed after the wound secretion bacteria cultivation results observation medication.

1.5 criterion of therapeutical effect is with reference to relevant criterion.Cure: ulcer area heals fully, forms crust or cicatrix.Produce effects: ulcer area is obviously dwindled, 1/2 the before＜treatment, and merocrine secretion's thing obviously reduces, and the slough major part comes off or part granulation new life.Effectively: ulcer area is dwindled, but the treatment before 1/2.Invalid: ulcer area is without obviously dwindling, and secretions is without obvious minimizing, and is local without significant change or deterioration person.

1.6 statistical procedures is used the SPSS11.0 statistical software.Measurement data is so that (x ± s) expression adopts the t check.

2 results

2.1 two groups of curative effects relatively see Table l.By as seen from Table 1, the treatment group curative effect is better than matched group (P＜0.05).

Table 1 liang group patient curative effect is n (%) relatively

Group

Number

Cure

Produce effects

Effectively

Invalid

Total effective rate

Treatment group

20

14(70)

3（15）

2(10)

1（5）

95

Matched group

20

6(30)

8（40）

2(10)

4（20)

80

Compare △ P＜0.05 with matched group.

3 discuss

Diabetic foot is one of serious complication of diabetes, is that diabetics causes death, the major reason that disables, and mainly take acral pain infection, ulcer, gangrene as main, biped is more serious in clinical manifestation.Footbath with traditional Chinese medicines obtains curative effect by the dual function of heat, medicine.The heat energy flesh muscle that relaxes, loose space between skin and muscles, promoting blood circulation to remove obstruction in the collateral, medicine is under the effect of heat energy, directly absorb by skin hole, acupuncture points on the human body etc. and to enter the blood network, defeated cloth whole body and bring into play drug action, but blood circulation promoting, blood vessel dilating improves surrounding tissue nutrition, excitating organism self-regulation function.

According to patient's disease, select corresponding prescription, great majority are activating blood and removing stasis drug, these medicines can be expanded lower limb vascular, suppress platelet aggregation, reduce blood viscosity, improve lower limb blood circulation, and diabetes are had obvious curative effect.But should note: (1) should suitably be strengthened this disease dosage; (2) avoid damaging healthy energy, be equipped with qi-invigorating, blood-nourishing medicinal; (3) to note monitoring coagulation function and hematoblastic variation in the medication.The treatment key is benefiting vital QI and blood, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting.Improve on the one hand the local blood capillary obstacle of lower limb, blood circulation promoting comes off slough as early as possible, reaches tissue repair; The medicines such as oral blood sugar lowering, blood pressure lowering, blood fat reducing are effectively controlled blood glucose, regulate blood viscosity, are reduced blood pressure on the other hand; To prevent simultaneously foot to infect the enhancing human body immunity function.Endo-medicine is effectively controlled blood glucose, regulates blood viscosity, is reduced blood pressure.Oral medicinal herb and external application can improve the ulcer surface microcirculation effectively, increase the groundwater increment of local organization, promote the regeneration of inflammation absorption and granulation tissue and epithelium, reach the purpose of ulcer surface wound healing.

Claims (10)

1. a Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot is characterized in that, formed by endo-medicine and external used medicine,

The ratio of weight and number of various crude drug is in the described endo-medicine: 10～20 parts of Rhizoma Corydalis, 10～20 parts in Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts in Poria, 10～20 parts of Radix Curcumaes, 10～20 parts on Flos Carthami, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Caulis Spatholobis, 10～20 parts of Pheretimas, 10～20 parts of Herba Dendrobiis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Cortex Cinnamomis, 10～20 parts of Semen Sinapis Albaes, 10～20 parts of Radix Paeoniae Rubra;

The ratio of weight and number of various crude drug is in the described external used medicine: 10～30 parts of Herba Asaris, 10～30 parts of Radix Clematidis, 10～30 parts of Radix Notoginseng, 10～30 parts of Olibanums, 10～30 parts of Myrrhas, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 10～30 parts of dried Alumens, 10～30 parts of Rhizoma Smilacis Glabraes, 10～30 parts of Radix Sanguisorbae preparatas, 10～30 parts on Flos Carthami, 10～30 parts of Fructus Cnidiis, 10～30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～30 parts of Rhizoma Drynariae.

2. the Chinese medicine composition of described treatment QI and blood deficiency blood stasis type diabetic foot according to claim 1 is characterized in that,

The ratio of weight and number of various crude drug is in the described endo-medicine: 10～15 parts of Rhizoma Corydalis, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Achyranthis Bidentataes, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts in Poria, 10～20 parts of Radix Curcumaes, 10～20 parts on Flos Carthami, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Caulis Spatholobis, 10～20 parts of Pheretimas, 10～20 parts of Herba Dendrobiis, 10～20 parts of Eupolyphaga Seu Steleophagas, 10～20 parts of Cortex Cinnamomis, 10～20 parts of Semen Sinapis Albaes, 10～20 parts of Radix Paeoniae Rubra;

The ratio of weight and number of various crude drug is in the described external used medicine: 10～15 parts of Herba Asaris, 10～15 parts of Radix Clematidis, 10～15 parts of Radix Notoginseng, 10～15 parts of Olibanums, 10～15 parts of Myrrhas, 10～15 parts of Radix Et Rhizoma Rhei, 10～15 parts of Cortex Phellodendris, 10～30 parts of dried Alumens, 10～30 parts of Rhizoma Smilacis Glabraes, 10～30 parts of Radix Sanguisorbae preparatas, 10～30 parts on Flos Carthami, 10～30 parts of Fructus Cnidiis, 10～30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～30 parts of Rhizoma Drynariae.

3. the Chinese medicine composition of described treatment QI and blood deficiency blood stasis type diabetic foot according to claim 1 is characterized in that,

The ratio of weight and number of various crude drug is in the described endo-medicine: 10～20 parts of Rhizoma Corydalis, 10～20 parts in Radix Rehmanniae Preparata, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts in Poria, 10～15 parts of Radix Curcumaes, 10～15 parts on Flos Carthami, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Caulis Spatholobis, 10～15 parts of Pheretimas, 10～15 parts of Herba Dendrobiis, 10～15 parts of Eupolyphaga Seu Steleophagas, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Semen Sinapis Albaes, 10～15 parts of Radix Paeoniae Rubra;

The ratio of weight and number of various crude drug is in the described external used medicine: 10～30 parts of Herba Asaris, 10～30 parts of Radix Clematidis, 10～30 parts of Radix Notoginseng, 10～30 parts of Olibanums, 10～30 parts of Myrrhas, 10～30 parts of Radix Et Rhizoma Rhei, 10～30 parts of Cortex Phellodendris, 10～15 parts of dried Alumens, 10～15 parts of Rhizoma Smilacis Glabraes, 10～15 parts of Radix Sanguisorbae preparatas, 10～15 parts on Flos Carthami, 10～15 parts of Fructus Cnidiis, 10～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～15 parts of Rhizoma Drynariae.

4. one kind such as the preparation method of the Chinese medicine composition for the treatment of QI and blood deficiency blood stasis type diabetic foot as described in each in the claim 1～3, it is characterized in that the dosage form of described Chinese medicine composition endo-medicine is granule, and its preparation method comprises:

A. described crude drug is put into the pulverizer grinding and sieving;

B. the rear remaining particulate matter that will sieve is put into the ethanol heating and refluxing extraction 2 times;

C. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol and spray drying get medicated powder; The fine powder that mixing sieves obtains is packed in the bag.

5. described preparation method according to claim 4 is characterized in that, among the described step a, described crude drug is put into cross 100-120 order dusting cover after pulverizer is pulverized, and the fine powder amount that enable pass is crossed sieve aperture is reaching 30%-40%, collects by the raw material fine powder of sieve aperture for subsequent use.

6. described preparation method according to claim 4 is characterized in that, among the described step b, the rear remaining particulate matter that sieves is put into 10 times of amounts of weight portion, 75% ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution is merged leave standstill.

7. described preparation method according to claim 4, it is characterized in that, among the described step c, above-mentioned extracted twice liquid is merged, 1.35 filtrate when the concentrating under reduced pressure relative density is 80 ℃, Recycled ethanol is adjusted proportion to 1.06 with gained filtrate, pass into spray dryer and carry out spray drying, the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m ², the hothouse hot stream temperature is 80 ℃-100 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving is mixed in the bag of packing into raw material medicated powder.

8. the Chinese medicine composition of each described treatment QI and blood deficiency blood stasis type diabetic foot according to claim 1～3, it is characterized in that, medicine for external use agent type is powder in the described Chinese medicine composition, and its preparation method comprises: first Herba Asari and Radix Notoginseng are extracted according to described portion rate, make crystallization; All the other described components are mixed by proportioning except dried Alumen, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, decocted 1-2 hour, filter; Filtering residue adds water and decocted 1-2 hour again, filters; Mix extracted twice liquid, carry out squeeze and filter, get filtrate after the separation, extracted twice liquid concentrate drying is become powder, mix the crystal that distillation obtains, even with mixing after the dried Alumen pulverizing again, behind ultraviolet radiation for sterilizing and disinfecting, make powder.

9. described preparation method according to claim 8 is characterized in that the extraction of described Herba Asari and Radix Notoginseng is steam distillation or supercritical fluid extraction.

10. the Chinese medicine composition of each described treatment QI and blood deficiency blood stasis type diabetic foot according to claim 1～3, it is characterized in that the dosage form for oral administration of described Chinese medicine composition is: tablet, pin powder, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation or plaster; Exterior-applied formulation is: foot bath agent, tincture, powder, unguentum, spray, gauze agent, membrane agent or application.