CN103933405A - Pharmaceutical composition for treating qi-blood deficiency burn, and preparation method thereof - Google Patents

Pharmaceutical composition for treating qi-blood deficiency burn, and preparation method thereof Download PDF

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CN103933405A
CN103933405A CN201410195053.3A CN201410195053A CN103933405A CN 103933405 A CN103933405 A CN 103933405A CN 201410195053 A CN201410195053 A CN 201410195053A CN 103933405 A CN103933405 A CN 103933405A
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radix
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朱玉静
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Abstract

The invention discloses a pharmaceutical composition for treating qi-blood deficiency burn, and a preparation method thereof. The pharmaceutical composition comprises a drug for oral administration and a drug for external use, wherein the drug for external use comprises the following raw herbal materials: radix codonopsis, radix astragali seu hedysari, radix et caulis acanthopanacis senticosi, fiveleaf gynostemma herb, rhizoma anemarrhenae, rhizoma phragmitis, herba lophatheri, fructus forsythiae, rganbaceae gouania javanica, wild buckwheat rhizome, beard lichen, radix tinosporae, beauty-berry leaf, purpleflower holly leaf, aloe, cortex moutan radicis, radix arnebiae, radix cynanchi atrati, red powder, cortex lycii, eriocarpous glochidion leaf, semen persicae, fructus viticis, concha arcae, radix salviae miltiorrhizae, smallfruit fig aerial root, calculus bovis, borneol and honey. The pharmaceutical composition has the beneficial effects that the theory of the traditional Chinese medicine is utilized; the pharmaceutical composition comprises the drug for oral administration and the drug for external use, can be used for mainly benefiting qi and nourishing blood as well as clearing residual toxin after being orally administrated, and for mainly clearing away heat and toxic materials, closing sore and regenerating tissues and diminishing inflammation and stopping pain after being externally used, and has the advantages of being fast to take effect, good in treatment effect, high in safety and free from toxic and side effects on treating qi-blood deficiency burn after being orally administrated and externally used.

Description

Be used for the treatment of pharmaceutical composition of QIXUELIANGXU type burn and preparation method thereof
 
Technical field
The present invention relates to pharmaceutical technology, relate in particular to a kind of pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn and preparation method thereof.
 
Background technology
The damage being caused by flame, high-temp solid and intense radiation heat is referred to as burn.Burn is the tissue injury being caused by high temperature, chemical substance or electricity.The degree of burn is by the height of temperature, the length of action time and difference.Local variation can be divided into four degree.Lactic acid production when burn in visible blood increases, and the pH value of arteriovenous blood reduces, and along with organizing, blood capillary is handicapped to be increased the weight of, and anoxemia also increases weight.Burn reaches 1/3rd of total body surface area and can be in peril of one's life when above.
Burn can be classified according to mechanism, the degree of depth, degree and the associated injury and complication of injury.1, current,, can roughly burn be once divided into, two degree, three degree and fourth-degree burns to the different degree of depth of skin according to burn injury.2, in order better patient to be recommended timely and effectively to the burn center in different majors field, burn association of the U.S. has developed a set of compartment system, and under this system, burn is divided into severe, moderate and slight by degree.This will usually weigh according to a series of fact, as the body surface gross area (TBSA) of burn, whether injures the anatomical area at key, patient age and related injury etc.3, burn also can be distinguished by total body surface area accounting (TBSA), and then divides according to the degree of depth.In first degree burn (only having erythema, without vesicle) is not comprised in.Normally used method is called rule of Nine, can help the form a prompt judgement body surface area of patient's damaged of doctor.More accurate method is to distinguish the different proportion of adult and children's torso by Lund Browder chart.4, burn may be caused by different external heat source contact skin, such as flame, chemicals, friction, electric current, radiation and high temperature etc.Therefore burn also can be divided into chemical burn, electric burn, radiation burn and scald etc. accordingly.
Clinical manifestation is by the following aspects: the order of severity of burn depends on scope and the degree of depth of wounded tissue, and depth of burn can be divided into I degree, II degree and III degree.I degree burn injury is the lightest.Burned skin is rubescent, pain, obviously touch a tender spot, have and ooze out or edema., part bleaches when light pressure the injury, but there is no vesicle.II degree burn injury is darker.Skin blister.Vesicle bottom takes on a red color or white, has been full of limpid, sticky liquid.Touch a tender spot responsive, when compressing, bleach.III degree burn injury is the darkest.Burn surfaces can turn white, deliquescing or be black, carbonization hide-like.Become pale owing to burning skin, in pale skin people, be often mistaken as normal skin, but the no longer variable color of when compressing.The erythrocyte local skin that can make to burn destroying is cerise, has once in a while vesicle, and the hair in burn district is easy to extract, and feels to go down.III degree burn area does not generally have the pain sensation.Because the teleneuron of skin is destroyed.Usually will be through in a few days after burn, could distinguish dark II degree and III degree burn.
Chinese medicine thinks that burn is that pyretic toxicity people invade because heat-flash acts on human body, stagnation of QI-blood, and the lighter's skin and flesh rots, and severe one excessive noxious heat injures cloudy liquid in body, or pyretic toxicity inside fire attack internal organs, so that internal organs become estranged, imbalance of YIN and YANG.Distinguish that its clinical sign is divided into that burning hot impairment of body fluid, cloudy impairment of YANG are de-, fire-toxin caves in, QI and blood deficiency, weakness of the spleen and stomach.QIXUELIANGXU type wherein: low grade fever or do not generate heat, spiritlessness and weakness, inappetence, emaciated physique, lustreless complexion, wound surface granulation color is light, is difficult to healing; Light red tongue, white and thin fur, thready and weak pulse.
Western medical treatment burn adopts antimicrobial ointment or ointment, and vein input antibiotic.Antibiotic may contribute to prevention infection, but prolonged application antibiotic not only can cause drug resistance, can cause more toxic and side effects, and when the quality of human immunoglobulin and lazy weight, cellular immune function low, or when phagocyte performance and mass deficiency, antibiotic therapy is difficult to prove effective.
 
Summary of the invention
Technical problem to be solved by this invention is, a kind of pharmaceutical composition that is used for the treatment of burn and preparation method thereof is provided, this pharmaceutical composition comprises endo-medicine and external used medicine, for oral administration taking benefiting qi and nourishing blood, the clear residual poison of holding concurrently as main, be main in order to heat-clearing and toxic substances removing, expelling pus and promoting granulation, anti-inflammatory analgetic outward, that oral administration and externally treatment QIXUELIANGXU type burn has is rapid-action, good effect, safe, the advantage that has no side effect.
In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition for the treatment of QIXUELIANGXU type burn, wherein, comprise endo-medicine and external used medicine, described external used medicine comprises following raw medicinal material: Radix Codonopsis, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Herba Lophatheri, Fructus Forsythiae, hair mouth label, Rhizoma Fagopyri Dibotryis, Usnea, Radix Tinosporae, Fructus Hippophae, Folium Callicarpae Formosanae, Ilex purpurea Hassk.[I.chinensis Sims, Aloe, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Cynanchi Atrati, Hydrargyri Oxydum Rubrum, Cortex Lycii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Semen Persicae, Fructus Viticis, Concha Arcae, Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Calculus Bovis, Borneolum Syntheticum and Mel;
Described endo-medicine comprises following raw medicinal material: Radix Ginseng, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Herba Lophatheri, Sha Jiang, Fructus Forsythiae, Herba Sedi, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae, Radix Tinosporae, Fructus Hippophae, Fructus Luffae, Exocarpium Benincasae, Rhizoma Corydalis, Ilex purpurea Hassk.[I.chinensis Sims, Radix Rumicis Japonici, Cortex Moutan, Radix Cynanchi Atrati, Cortex Lycii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Semen Persicae and Calculus Bovis.
In described external used medicine, the parts by weight of each raw medicinal material are preferably: Radix Codonopsis 10-20 weight portion, Radix Astragali 10-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Herb Gynostemmae Pentaphylli 5-10 weight portion, Rhizoma Anemarrhenae 10-20 weight portion, Rhizoma Phragmitis 10-20 weight portion, Herba Lophatheri 5-15 weight portion, Fructus Forsythiae 10-20 weight portion, hair mouth label 10-20 weight portion, Rhizoma Fagopyri Dibotryis 5-15 weight portion, Usnea 5-15 weight portion, Radix Tinosporae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Folium Callicarpae Formosanae 10-20 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 5-9 weight portion, Aloe 15-25 weight portion, Cortex Moutan 10-20 weight portion, Radix Arnebiae (Radix Lithospermi) 5-10 weight portion, Radix Cynanchi Atrati 5-10 weight portion, Hydrargyri Oxydum Rubrum 10-20 weight portion, Cortex Lycii 10-20 weight portion, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 10-20 weight portion, Semen Persicae 10-20 weight portion, Fructus Viticis 10-20 weight portion, Concha Arcae 10-20 weight portion, Radix Salviae Miltiorrhizae 10-20 weight portion, Radix Aerio Fici Microcarpae 10-20 weight portion, Calculus Bovis 15-20 weight portion, Borneolum Syntheticum 15-25 weight portion and Mel 10-20 weight portion,
In described endo-medicine, the parts by weight of each raw medicinal material are preferably: Radix Ginseng 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 10-20 weight portion, Rhizoma Dioscoreae 10-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 5-15 weight portion, Herb Gynostemmae Pentaphylli 5-15 weight portion, Radix Rehmanniae Preparata 5-10 weight portion, Rhizoma Anemarrhenae 10-20 weight portion, Herba Lophatheri 10-20 weight portion, husky Rhizoma Zingiberis Recens 15-25 weight portion, Fructus Forsythiae 10-20 weight portion, Herba Sedi 5-10 weight portion, Rhizoma Fagopyri Dibotryis 10-15 weight portion, Caulis Sargentodoxae 10-15 weight portion, Radix Tinosporae 5-9 weight portion, Fructus Hippophae 10-15 weight portion, Fructus Luffae 10-20 weight portion, Exocarpium Benincasae 10-20 weight portion, Rhizoma Corydalis 10-20 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 5-9 weight portion, Radix Rumicis Japonici 10-20 weight portion, Cortex Moutan 10-15 weight portion, Radix Cynanchi Atrati 5-15 weight portion, Cortex Lycii 10-20 weight portion, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 5-15 weight portion, Semen Persicae 10-20 weight portion and Calculus Bovis 10-20 weight portion.
In described external used medicine, the parts by weight of each raw medicinal material can also be preferably: Radix Codonopsis 15 weight portions, the Radix Astragali 15 weight portions, Radix Et Caulis Acanthopanacis Senticosi 15 weight portions, Herb Gynostemmae Pentaphylli 7 weight portions, the Rhizoma Anemarrhenae 15 weight portions, Rhizoma Phragmitis 15 weight portions, Herba Lophatheri 8 weight portions, Fructus Forsythiae 15 weight portions, hair mouth label 15 weight portions, Rhizoma Fagopyri Dibotryis 11 weight portions, Usnea 10 weight portions, Radix Tinosporae 8 weight portions, Fructus Hippophae 15 weight portions, Folium Callicarpae Formosanae 15 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 7 weight portions, Aloe 21 weight portions, Cortex Moutan 15 weight portions, Radix Arnebiae (Radix Lithospermi) 8 weight portions, Radix Cynanchi Atrati 7 weight portions, Hydrargyri Oxydum Rubrum 15 weight portions, Cortex Lycii 15 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15 weight portions, Semen Persicae 15 weight portions, Fructus Viticis 15 weight portions, Concha Arcae 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Radix Aerio Fici Microcarpae 15 weight portions, Calculus Bovis 18 weight portions, Borneolum Syntheticum 20 weight portions and Mel 15 weight portions,
In described endo-medicine, the parts by weight of each raw medicinal material can also be preferably: Radix Ginseng 15 weight portions, Radix Codonopsis 15 weight portions, the Radix Astragali 15 weight portions, Rhizoma Dioscoreae 15 weight portions, Radix Et Caulis Acanthopanacis Senticosi 7 weight portions, Herb Gynostemmae Pentaphylli 8 weight portions, Radix Rehmanniae Preparata 7 weight portions, the Rhizoma Anemarrhenae 15 weight portions, Herba Lophatheri 15 weight portions, husky Rhizoma Zingiberis Recens 21 weight portions, Fructus Forsythiae 15 weight portions, Herba Sedi 7 weight portions, Rhizoma Fagopyri Dibotryis 12 weight portions, Caulis Sargentodoxae 12 weight portions, Radix Tinosporae 6 weight portions, Fructus Hippophae 12 weight portions, Fructus Luffae 15 weight portions, Exocarpium Benincasae 15 weight portions, Rhizoma Corydalis 15 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 7 weight portions, Radix Rumicis Japonici 15 weight portions, Cortex Moutan 12 weight portions, Radix Cynanchi Atrati 8 weight portions, Cortex Lycii 15 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 7 weight portions, Semen Persicae 15 weight portions and Calculus Bovis 15 weight portions.
In described external used medicine, the parts by weight of each raw medicinal material can be preferably again: Radix Codonopsis 10 weight portions, the Radix Astragali 10 weight portions, Radix Et Caulis Acanthopanacis Senticosi 10 weight portions, Herb Gynostemmae Pentaphylli 5 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Rhizoma Phragmitis 20 weight portions, Herba Lophatheri 5 weight portions, Fructus Forsythiae 10 weight portions, hair mouth label 20 weight portions, Rhizoma Fagopyri Dibotryis 5 weight portions, Usnea 15 weight portions, Radix Tinosporae 5 weight portions, Fructus Hippophae 10 weight portions, Folium Callicarpae Formosanae 20 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 9 weight portions, Aloe 25 weight portions, Cortex Moutan 20 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Radix Cynanchi Atrati 5 weight portions, Hydrargyri Oxydum Rubrum 20 weight portions, Cortex Lycii 20 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 20 weight portions, Semen Persicae 10 weight portions, Concha Arcae 15 weight portions, Fructus Viticis 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Radix Aerio Fici Microcarpae 15 weight portions, Calculus Bovis 15 weight portions, Borneolum Syntheticum 15 weight portions and Mel 10 weight portions,
In described endo-medicine, the parts by weight of each raw medicinal material can be preferably again: Radix Ginseng 20 weight portions, Radix Codonopsis 20 weight portions, the Radix Astragali 20 weight portions, Rhizoma Dioscoreae 20 weight portions, Radix Et Caulis Acanthopanacis Senticosi 5 weight portions, Herb Gynostemmae Pentaphylli 5 weight portions, Radix Rehmanniae Preparata 10 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Herba Lophatheri 10 weight portions, husky Rhizoma Zingiberis Recens 15 weight portions, Fructus Forsythiae 20 weight portions, Herba Sedi 10 weight portions, Rhizoma Fagopyri Dibotryis 15 weight portions, Caulis Sargentodoxae 10 weight portions, Radix Tinosporae 5 weight portions, Fructus Hippophae 10 weight portions, Fructus Luffae 20 weight portions, Exocarpium Benincasae 20 weight portions, Rhizoma Corydalis 10 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 5 weight portions, Radix Rumicis Japonici 10 weight portions, Cortex Moutan 15 weight portions, Radix Cynanchi Atrati 5 weight portions, Cortex Lycii 10 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15 weight portions, Semen Persicae 20 weight portions and Calculus Bovis 10 weight portions.
In order better to realize foregoing invention object, the invention provides a kind of preparation method of the pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn, the dosage form of described external used medicine is ointment, its preparation method comprises: get the described parts by weight except Borneolum Syntheticum and Mel raw medicinal material mix after in water, soak 1-2 hour, then be placed in multi-function extractor, decoct for the first time amount of water and be mix medical material weight 5-10 doubly, decoct, while being heated to 100 DEG C, start timing, micro-boiling after 2 hours, filters and emits medicinal liquid from feed opening, puts in fluid reservoir; Decoct for the second time, amount of water is that the 5-10 that mixes medical material weight doubly measures, and is heated to 100 DEG C, and micro-boiling after 2 hours, extracts medicinal liquid out, merges with the medicinal liquid decocting for the first time; By merging in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the extractum that temperature to 60 is DEG C-70 DEG C is cooling; Rear Borneolum Syntheticum pulverizing and Mel are added in extractum to tinning after ultraviolet radiation sterilizing.
The dosage form of described endo-medicine is capsule, and its preparation method comprises:
A. described raw medicinal material is put into pulverizer grinding and sieving;
B. particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times;
C. get again the medicinal residues after above-mentioned ethanol extraction, the heating and refluxing extraction that adds water 2 times;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying are dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
Wherein, in described step a, described raw medicinal material is put into after pulverizer is pulverized and crossed 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%~40%, collects by the raw material fine powder of 120 mesh sieves for subsequent use.
In described step b, particulate matter remaining after sieving is put into the ethanol heating and refluxing extraction 2 times that ratio of weight and number is 5~7 times of amounts, each 1~2 hour, 2 extracting solution are merged and left standstill; In described step c, it is 5~7 times of water gaging heating and refluxing extraction 2 times that the medicinal residues that above-mentioned ethanol extraction is crossed add ratio of weight and number, each 1~2 hour, 2 extracting solution is merged and is left standstill.
In described steps d, above-mentioned two kinds of extracting solution are merged, the filtrate of 1.38 o'clock when concentrating under reduced pressure relative density is 50 DEG C~60 DEG C, reclaims ethanol, and gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of crossing spray dryer shower nozzle is 4kg/m 2, hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and incapsulated with raw material medicated powder.
The dosage form of described endo-medicine is tablet, and its preparation method comprises:
The first step, is mixed in proportion described each raw medicinal material, the ethanol that to add with respect to the determining alcohol of 4~5 times of mixture qualities be 85%~90%, and reflux 2~4 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 90%~95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 2~3 times of described medicinal residues quality again, reflux 1~3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2~3 hours, pulverizes, and sieves, and obtains 300 order~400 object micropowders;
The 3rd step, the micropowders that second step is obtained, add with respect to the microcrystalline Cellulose of 0.1~0.3 times of its quality, 0.15~0.3 times of lactose, the starch of 0.2~0.35 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.025~0.04 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
The invention has the beneficial effects as follows: pharmaceutical composition of the present invention utilizes the traditional theory of Chinese medical science of China, comprise endo-medicine and external used medicine, for oral administration taking benefiting qi and nourishing blood, the clear residual poison of holding concurrently as main, be main in order to heat-clearing and toxic substances removing, expelling pus and promoting granulation, anti-inflammatory analgetic outward, that oral administration and externally treatment QIXUELIANGXU type burn has is rapid-action, good effect, safe, the advantage that has no side effect.
 
Detailed description of the invention
The invention provides a kind of pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn, wherein, comprise endo-medicine and external used medicine, described external used medicine comprises following raw medicinal material: Radix Codonopsis, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Herba Lophatheri, Fructus Forsythiae, hair mouth label, Rhizoma Fagopyri Dibotryis, Usnea, Radix Tinosporae, Fructus Hippophae, Folium Callicarpae Formosanae, Ilex purpurea Hassk.[I.chinensis Sims, Aloe, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Cynanchi Atrati, Hydrargyri Oxydum Rubrum, Cortex Lycii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Semen Persicae, Fructus Viticis, Concha Arcae, Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Calculus Bovis, Borneolum Syntheticum and Mel;
Described endo-medicine comprises following raw medicinal material: Radix Ginseng, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Herba Lophatheri, Sha Jiang, Fructus Forsythiae, Herba Sedi, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae, Radix Tinosporae, Fructus Hippophae, Fructus Luffae, Exocarpium Benincasae, Rhizoma Corydalis, Ilex purpurea Hassk.[I.chinensis Sims, Radix Rumicis Japonici, Cortex Moutan, Radix Cynanchi Atrati, Cortex Lycii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Semen Persicae and Calculus Bovis.
Wherein, in external used medicine, Radix Ginseng, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, Radix Rehmanniae Preparata benefiting qi and nourishing blood, poison holding; The Rhizoma Anemarrhenae, Rhizoma Phragmitis, Herba Lophatheri, Calculus Bovis, Fructus Forsythiae, Herba Sedi, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae, Radix Tinosporae, Fructus Hippophae heat-clearing and toxic substances removing, invigorating the spleen and regulating the stomach; Hair mouth label heat-clearing and toxic substances removing, astringing to arrest bleeding; Expelling pus and promoting granulation when Radix Ampelopsis, Ilex purpurea Hassk.[I.chinensis Sims, Radix Rumicis Japonici, Semen Persicae heat-clearing and toxic substances removing removing heat from blood; Usnea, Mel, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) bactericidal antiphlogistic, heat-clearing and toxic substances removing; Fructus Viticis, Concha Arcae, Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Rhizoma Corydalis and Folium Callicarpae Formosanae, Aloe and Hydrargyri Oxydum Rubrum compatibility have effect of anti-inflammatory analgetic, hemostasis dissipating blood stasis; Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Cynanchi Atrati, Cortex Lycii and husky Rhizoma Zingiberis Recens, Fructus Luffae, Exocarpium Benincasae can clearind deficient heats, detoxification sore treatment.Make a general survey of full side, compatibility science, rigorous, drug safety, effectively.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Radix Ginseng: sweet, micro-hardship, flat.Return spleen, lung, heart channel.Function cures mainly: strongly invigorating primordial QI, and multiple arteries and veins is admittedly de-, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.
Radix Codonopsis: property is flat, sweet in the mouth, micro-acid; Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.These product are clinical conventional Qi-tonifying drug, function invigorating the spleen to benefit the lung, effect person of modern times ginseng and for a little less than, be applicable to various deficiency of vital energy deficiency persons.Contained saponin, inulin, Alkaloid, starch etc. have strong effect in various degree to the many internal organs of human body, can improve the adaptability of human body.There is antiulcer, can increase intestinal tension force, regulate stomach motion, in the intestines and stomach coordinating preparation, reuse the intestines and stomach regulation of mental activities agent of Radix Codonopsis to chronic diarrhea, ulcerative colitis, antral gastritis, chronic atrophic gastritis etc. quite have effect.
The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Essentials of Matea Medica: " lossless can sending out, has antiperspirant to stop for the Radix Astragali, life consolidating superficial resistance; Process with invigorating middle warmer beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." " herbal justice ": " and the Radix Astragali, soil in tonification, replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and sagging person is the most suitable for clearing heat in QI system.The through people's of its skin skin table muscle, solid protection is defended sun, enriches table point, is its speciality, thus all diseases of exterior deficiency, the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.The Radix Astragali strengthens heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; Can improve the nonspecific immunity power of body, protect the liver and fall hypoglycemic effect, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had to inhibitory action.The Radix Astragali can appreciable impact splenocyte Information Conduction, realizes immunoregulation effect.Can be used for hypertension, ischemic heart desease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis.
Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red card such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, leukorrhagia.This product yin nourishing can help wet, contain fullness in the epigastrium and abdomen so wet or have stagnant, person is unsuitable excess pathogen.
Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, a little less than body weakness with emaciation, traumatic injury, fracture, edema, beriberi, the uncontrolled urination card such as itch.The sweet A of Radix Et Caulis Acanthopanacis Senticosi is also containing this constituents in carotene , Ren Ginseng.In human body, can promote the excretion of cholesterol, can prevent and treat Blood Cholesterol too high levels disease.The sweet B of Radix Et Caulis Acanthopanacis Senticosi is Syringa oblata Lindl. element (Syringin), is the main strong composition of Radix Et Caulis Acanthopanacis Senticosi, has short gonad, radioprotective, fatigue-resisting function, has the physiologically active similar to Ren Ginseng Saponin.Radix Et Caulis Acanthopanacis Senticosi is containing super oxidation disproportionation ferment SOD (Superoxide dimutase) complex, SOD has good anti-oxidation function, can strengthen the effect that human immunity and opposing free radical are attacked, there is antioxidation, can strengthen body immunity, prevent aging and promotion health.
Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature; Return lung meridian, spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.After small number of patients is taken medicine, there is the symptoms such as nausea and vomiting, abdominal distention diarrhoea (or constipation), dizziness, dim eyesight, tinnitus.Take after Herb Gynostemmae Pentaphylli, enterogastric peristalsis is accelerated, and it is long that appetite increases the resistance to time of hungering and thirst, and not only treats constipation but also control loose stool.Reaction excited to cerebral cortex and that suppress can keep suitable balance, and nervus centralis is had to dual regulation.There is good analgesia, sleep peacefully, antitonic effect.Reducing myocardial wall anxiety, relaxing on the basis of cerebrovascular and peripheral vascular resistance, can strengthen heart and brain vigor, strengthen coronary flow, relax arteriosclerosis, impel entirety circulation more vigorous and smooth.Experiment showed, not that diet is rich and take Herb Gynostemmae Pentaphylli group, and avoid meat and refuse to obey Herb Gynostemmae Pentaphylli group, make regular check on comparison, body inner bag is solid close with neutral fat content.Herb Gynostemmae Pentaphylli has optimum conversion regulating action to body fat mass in human body as can be seen here.Take the mouse comparison of Herb Gynostemmae Pentaphylli and disobedience, the approximately long 31-57% of its swimming time, and antisecosis is also faster, people takes after Herb Gynostemmae Pentaphylli, and physical energy is more abundant, and even indefatigability be also easy to recover tired, thereby work efficiency increases.Human body part function weakness, can produce allergy to Cucumber, and forms the diseases such as bronchus is panted, skin rashes, arthralgia, and Herb Gynostemmae Pentaphylli is rather good to these sick effects.
Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature, enters liver, kidney channel, Compendium of Material Medica: " fill out bone marrow, longue meat, promoting generation of vital essence and blood.Tonifying five ZANG-organs internal injury deficiency, promoting blood circulation, sharp knowledge, black beard and hair, man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion, irregular menorrhea, tire produces all kinds of diseases and ailments." thering is the YIN nourishing of enriching blood, beneficial essence is filled out the effect of marrow, for blood deficiency and yellow complexion; Dizzy, cardiopalmus, insomnia, menoxenia, collapses more than; Hepatic and renal YIN deficiency, night sweat, sufficient knee joint pain, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted, seminal emission sexual impotence, infertility, menoxenia, metrostaxis, early whitening of beard and hair, quenches one's thirst, the cards such as dyspnea with rapid and short breath of suffering from a deficiency of the kidney.This product character is sticky, compared with Radix Rehmanniae more very, hinders digestion, and all stagnation of QI abundant expectoration, abdominal distention, anorexia and loose stool person avoid clothes.Reusing clothes of a specified duration should be equal to use with Pericarpium Citri Reticulatae, stir-fry core, prevents the sticky stomach that hinders.Radix Rehmanniae Preparata decoct treatment hypertension, blood pressure, serum cholesterol and triglyceride all have decline, and rheoencephalogram and electrocardiogram also make moderate progress.Radix Rehmanniae Preparata can significantly suppress liver hemorrhagic necrosis kitchen range and simple necrosis.Wine Radix Rehmanniae Preparata and cook Radix Rehmanniae and have significant hypotensive effect, systolic pressure and diastolic pressure all significantly decline.
The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, there is the relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, property sedimentation, can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also be used for the treatment of diabetes; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire.
Rhizoma Phragmitis: sweet, cold; Return lung meridian, stomach warp." property of medicine opinion ": " can separate large heat, appetizing.Control the sound of vomiting of choking more than." " Japan hanako materia medica ": " and disease unhappiness while controlling cold and heat, good pregnant people's heat in the heart, and dysentery people is thirsty." clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Rhizoma Phragmitis is for gastropyretic vomiting.Rhizoma Phragmitis can clearing heat to ease the stomach preventing or arresting vomiting, does not grow again the greasy stomach that hinders, therefore the key medicine of vomitting the sound of vomiting for controlling gastric heat.Can suppress the caused contractile response of electricity irritation of frog neuromuscular specimen and the picked-up of the oxygen of diaphragm in rats and anaerobic glycolysis, in vitro Cavia porcellus intestinal tube is had to relexation.
Herba Lophatheri: nature and flavor, sweet, be slightly cold.Compendium of Material Medica: " go dysphoria with smothery sensation, diuresis, relieving restlessness is quenched the thirst, children's's pox poison, outer disease is vicious." effect clearing heat and relieving fidgetness, inducing diuresis for treating stranguria syndrome." vegetation is side just ": " expectorant is quenched the thirst.Control dysphoria with smothery sensation, cough with asthma, spits blood, the sound of vomiting of vomitting, pediatric epilepsy scared." for calentura excessive thirst, heart stomach-fire is contained.Folium Bambosae extract is a kind of bioflavonoid health care nutrient newly developed, has good antiradical activities and conclusive quasi-SOD activity; Can compare favourably with VC to the blocking ability of nitrosation reaction; Effect and the pollen of defying age, anti-stress and resisting fatigue are suitable; Blood fat reducing and cholesterolemia, antioxidative effect are identical with Folium Ginkgo extract; Antibacterial, antiinflammatory is similar to tea polyphenols with antivirus action; Effect victory Succus Bambusae one of relieving cough and expelling phlegm, heat-clearing and toxic substances removing is raised; And there is significant immunological enhancement, can improve the resistance of human body to poor environment and disease: also there is good hydrothermal stability, antioxidative stabilizer and unique Folium Bambusae delicate fragrance., containing any harmful components and antinutritional factor, without toxicity, side effect, not a kind of very good pure natural health-care.
Fructus Forsythiae: bitter in the mouth, cold nature; Enter the heart, lung, small intestine meridian." property of medicine opinion ": " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat." Tang Materia Medica: " Fructus Forsythiae has two kinds, sticks up greatly, Herba Hyperici Erecti.Stick up greatly leaf long and narrow, as Herba Stachydis Japonicae, brightly yellowish lovely, give birth to wetland, work, like the real person of not opening of Chinese toon, sticks up outstanding grass as room.On the raw hilllock of its Herba Hyperici Erecti is former, Ye Huashi is all little thin like sticking up greatly, and mountain people from south also uses it.Under modern capital, only with sticking up greatly son, spend also without stem." have antibacterial, heart tonifying, diuresis, town the pharmacological action such as to tell, be the Chinese medicine of heat-clearing and toxic substances removing, cure mainly calentura from the beginning of symptom, its bacteriostasis and Flos Lonicerae broadly similars such as, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus.Weakness of the spleen and stomach, fever due to deficiency of QI, carbuncle is burst, the light person of the rare color of pus avoids clothes.The contained oleanolic acid of this product has heart tonifying, diuresis and hypotensive activity, and Citrin can reduce vascular permeability and fragility, prevents haemolysis.Decoct has the town effect of telling, anti-liver injury effect.
Herba Sedi: cool in nature, sweet in the mouth, cool; Return liver, gallbladder, small intestine meridian.Eliminating damp-heat, removing toxic substances.For jaundice due to damp-heat, dysuria, carbuncle skin infection, acute hepatitis, chronic hepatitis.There is the effect of the glutamate pyruvate transaminase of reduction.For the activeness of acute hepatitis, chronic persistent hepatitis, chronic hepatitis.For burn due to hot liquid or fire, available fresh grass is cleaned and is smash juice and be coated with outward; For carbuncle from the beginning of, except decoct soup for oral administration, mash external application with fresh grass is clean simultaneously, also can eliminating carbuncle detumescent.Herba Sedi was the conventional medical herbs for the treatment of carbuncle sore among the people and venom originally, but off guard because of general shop of Chinese medicines, applied less therefore different clinically in the past.These product of discovered in recent years can be with controlling infectious hepatitis, and reduction is turned to ammonia Enzyme good short term effect.
Hair mouth label: micro-hardship, puckery, cool.Function cures mainly: heat-clearing and toxic substances removing, astringing to arrest bleeding.
Rhizoma Fagopyri Dibotryis: cool in nature, acrid in the mouth, hardship.Energy heat-clearing and toxic substances removing, the eliminating carbuncle of invigorating blood circulation, expelling wind and removing dampness sore, snake bite and insect sting.Main lung abscess, lung-heat cough with asthma, laryngopharynx swelling and pain, dysentery, rheumatism arthromyodynia, traumatic injury, carbuncle cancer.
Caulis Sargentodoxae: bitter in the mouth, property is flat, returns liver, large intestine channel, " Hunan medicine will ": " stimulate the menstrual flow and enrich blood, bone and muscle strengthening, anthelmintic.Control traumatic injury, rheumatalgia, bruise, stranguria with blood, bones and muscles pain, furuncle, filaricide." " simple and easy medical herbs ": " control bones and muscles pain, chase after wind, strong waist knee joint, tonifying YANG thing." there is the eliminating carbuncle of relieving internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cures mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.The effect of Isolated Toad Heart is pressed to Ba Mushi isolated heart device, with 20ml ringer solution perfusion, 0.1g Caulis Sargentodoxae is added to (0.5%) in perfusate, find isolated heart to be slight inhibition, performance heart contracting power weakens, decreased heart rate (P0.05), and cardiac output reduces (P0.01).To the effect of isolated rabbit aortic article, by the aortic article of isolated rabbit, result blood vessel starts to occur obvious contraction, and this effect can be blocked by phentolamine, points out its contraction may be receptor related with a-.Gradually there is again subsequently lasting relexation.
Usnea: sweet, flat.Function cures mainly: heat-clearing and toxic substances removing, relieving cough and resolving phlegm.For pulmonary tuberculosis (sodium salt of multiplex usnic acid), chronic bronchitis; Traumatic infection is controlled in external, and postoperative incision infects, suppurative otitis media, furuncle, tuberculous lymphadenitis, mastitis, burn, cervical erosion, trichomonas vaginitis.
Radix Tinosporae: hardship, cold.Return lung, large intestine channel." property of medicine is examined ": " removing toxic substances.Throat numbness is anxious, and erosion of mucous membrane of the oral cavity should take.The red furuncle Skin-disease of cellulitis carbuncle carbuncle on the back , inflammation, snakes and scorpions insect bite, mill is coated with.Control ophthalmalgia, bulge of the ear, cough due to heat, haze miasma, tells nosebleed, all outer diseases." " the little knowledge in Citrus chachiensis Hort. garden ": " and the inside and outside stagnation of pathogenic heat of dispelling, all over vicious, the communicable subtropical diseases that disappear, two single throat moth and toothache, shave contains; Mill is coated with furuncle swelling toxin." function heat-clearing and toxic substances removing, sore-throat relieving, reducing swelling and alleviating pain.For laryngopharynx swelling and pain, carbuncle furunculosis, has loose bowels, dysentery, gastral cavity abdomen burning pain.Except decoct soup for oral administration, also can mash external application with fresh grass.For traumatic hemorrhage, available Radix Glycyrrhizae levigation, spreading wrapping; Swell and ache with controlling blood stasis, appropriate with fresh grass, mash external application.
Fructus Hippophae: Fructus Hippophae and oil have very high medical value, can reduce cholesterol, allevating angina pectoris outbreak, prevents and treats the effect of coronary atherosclerotic heart disease in addition; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis; Can treat gastric duodenal ulcer and dyspepsia etc., evident in efficacy to diseases such as chronic superficial gastritis, atrophic gastritis, colitis; Burn, scald, cutter burning, cold injury are had to good therapeutical effect; Cervical erosion is had to good therapeutic effect.In sea buckthorn fruit, contain 7 kinds of Endospermum chinense Benth. materials such as isorhamnetin and glucoside thereof, Quercetin, nimbecetin, the usefulness that has cough-relieving, relievings asthma and eliminate the phlegm, expand coronary vasodilator, reduce cholesterol, is usually used in treating ischemic heart desease, and treatment angina pectoris effective percentage is reached to 94%.In Fructus Hippophae, SOD active component is abundant, and every gram of sea-buchthorn fresh fruit SOD content reaches 2746.0 enzyme units, and its content is 4 times of Radix Ginseng.It can block the free radical producing because of substance in vivo peroxidating, and the generation of this free radical and human senility, disease is closely related.
Folium Callicarpae Formosanae: bitter, puckery, flat.Function cures mainly: hemostasis, dissipating blood stasis, antiinflammatory.For epistaxis, spitting of blood, gastrointestinal hemorrhage, metrorrhagia, upper respiratory tract infection, tonsillitis, pneumonia, bronchitis; Traumatic hemorrhage is controlled in external, burn.
Ilex purpurea Hassk.[I.chinensis Sims: hardship, puckery, cool." Bencao Tujing ": " ashing, face cream is coated with it, controls chap chilblain special effect, the double scar defect that goes out." Ilex purpurea Hassk.[I.chinensis Sims controls cough due to lung-heat, laryngopharynx swelling and pain, pyretic stranguria, dysentery.This product bitter cold, is good at clearly purte the white and relieving heat toxin.Stop up cough, pharyngalgia and anemopyretic cold on lung-fire; Or invade under pyretic toxicity, the puckery pain of dribbling urination, dysentery person, alone this product imitates.The Ilex purpurea Hassk.[I.chinensis Sims heating that cures cold, cough due to lung-heat, laryngopharynx swelling and pain, the puckery pain of dribbling urination and dysentery, diarrhoea disease, can alone this product one or two, decoction; Also can coordinate Herba Taraxaci, Herba Cayatiae Japonicae, Commeline communis to be equal to use.This product has the effect of astringing to arrest bleeding.For traumatic hemorrhage, can smash deposited wound by alone fresh leaf; Also can use cured leaf porphyrize, spread and apply at wound, additional wrapping.
Radix Rumicis Japonici: hardship, cold in nature, GUIXIN, liver, large intestine channel." Japan hanako materia medica ": " control tinea, kill all worm toxic swellings, the vinegar subsides that rub." effect clearing away heat and loosing the bowels, cooling blood for hemostasis, killing parasites for relieving itching.Cure mainly constipation, hematemesis and epistaxis, discharging fresh blood stool, hemorrhoidal bleeding, metrorrhagia, scabies, bald, carbuncle pyogenic infections from tumour or sore, traumatic injury in vain.Join Cacumen Platycladi, cooling blood for hemostasis, the two mutual reinforcement between is use, treats the blood disorder that of the absurd row of heat in blood forcing blood.Join Alumen, removing toxic substances parasite killing is treated tinea, for carbuncle pyogenic infections from tumour or sore, and eczema scabies, tinea pruritus etc.Radix Rumicis Crispi tincture has certain inhibitory action to multiple pathomycete in vitro.After Radix Rumicis Crispi (kind is not identified) decoct is concentrated, alcoholic extract has inhibitory action to acute lymphoblastic type leukemia, acute monocyte type leukemia and Acute granulocytic leukemia patient hemocyte dehydrogenase.Similar to Radix Et Rhizoma Rhei, low dose has convergence, has in a large number laxative effective.And the reflexive function of gallbladder promoting of energy, also there is some anastalsis.
Aloe: bitter in the mouth is cold in nature, removing heat from the liver, relieving constipation, parasite killing; In addition for headache, constipation, pediatric epilepsy scared, infantile malnutrition infections furuncle and phyma, burn and scald, tinea skin ulcer, hemorrhoid, atrophic rhinitis, scrofula, hepatitis, Biliary Calculi, exudative dermatitis etc.In the blade of Aloe, contain and exceed 200 kinds of compounds, in the middle of include 20 kinds of mineral, 18 seed amino acids, 12 kinds of vitamin and other various nutrients, comprise multiple mucopolysaccharide, fatty acid, Anthraquinones and flavone compound, sugar, organized enzyme etc.Anthraquinones has another name called Anthraquinone Complex, has effect of disinfection, is mainly present in juice.
Cortex Moutan: bitter in the mouth, pungent, cold nature, enters the heart, liver, kidney channel." herbal classic ": ", except the hard blood stasis of disease stays house the intestines and stomach, settling five organs, treats carbuncle skin ulcer for main cold and heat, apoplexy Chi Zong, convulsion, infantile convulsion pathogen." " Japan hanako materia medica ": " except pathogen, happy color, the natural fibre line of meat blood vessels of being open to the custom, evacuation of pus, logical menstruation, disappears and flutters damage blood stasis, reuniting the fractured tendons and bones, except migratory arthralgia, the tire lower eyelid that falls, puerperal all cold and hot vim and vigour."。Compendium of Material Medica: " nourishing YIN to lower pathogenic fire is separated speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." there is the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in treating the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, hot Fu Yin of calentura later stage divides heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutter the card such as the pain of injury, rheumatism pyretic arthralgia.Kind purifying the blood, and invigorate blood circulation, thereby have effect of cool the blood dissipate blood stasis, make blood flow freely and not stay the stasis of blood, the absurd clearly and not row of heat in blood.Therefore to diseases such as intense heat in the blood, Liver and kidney hyperactivity of fire and stagnation of blood stasis, all rely on as key medicine.Cortex Moutan can increase coronary flow to the anesthetized dog heart, reduces cardiac output, reduces the effect of left chamber work done.The mice heating that paeonol oral disposition typhoid fever, paratyphoid vaccine cause has refrigeration function, and reduces normal mouse body temperature.
Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, salty, GUIXIN, Liver Channel, Compendium of Material Medica: " Radix Arnebiae (Radix Lithospermi), its merit is longer than removing heat from blood and promoting blood circulation, sharp intestine and small intestine.Therefore varioliform exanthema is wanted out, heat in blood poison is contained, and stool closes puckery person and should use it, goes out and the purple melena person of cutting also can use.If go out and red work, and in vain fall into convenience person, cut compatibility and incompatibility of drugs it." " Bencao Jingshu ": " key medicine that Radix Arnebiae (Radix Lithospermi) is removing heat from blood, therefore the gas of main trusted subordinate's pathogenic heat." be mainly used in that heat in blood poison is contained, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire etc.The ether of Radix Arnebiae (Radix Lithospermi), water, ethanol extraction all have certain antiinflammatory action.Radix Arnebiae (Radix Lithospermi) decoct is oral, and to rabbit experiment, heat pyrexia has the refrigeration function of mitigation, and its extract and pigment composition also have slight refrigeration function.
Radix Cynanchi Atrati: " modern Practical Chinese medicinal ": " control the extremity edema of apoplexy patient, again for the hectic fever of the scorching hot and weak disease in acute calenture latter stage, the osteopyrexia and fever of pulmonary tuberculosis etc., have the effect of refrigerant property nourishing; Also puckery for urine again, the cards such as cough due to lung-heat." clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment.For pathogenic warmth wound battalion heating, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood, swollen ulcer drug.
Hydrargyri Oxydum Rubrum: pungent, heat; Function cures mainly: dial poison, and except pus, removing the necrotic tissue, granulation promoting.For carbuncle furuncle, syphilitic chancre, all malignant boil, meat is dark violet black, and slough does not go, sinus tract fistula, pus is dripping, does not close up for a long time.
Cortex Lycii: cold in nature, sweet in the mouth; Enter lung, liver, kidney channel." not Lu ": " main air is wet, lower breast side of body gas, exopathogenic heat headache, mends internal injury great Lao suctions of hissing, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, summer-heat resists cold." " book on Chinese herbal medicine is stated ": " cures mainly deficient fever, and alternate attacks of chills and fever is allly shown in blood disorder, epistaxis, cough blood, and cough, breathe heavily, diseases due to endogenous heat of ZANG FU organs, apoplexy, dizzy, convulsion is chronic, lumbago, migratory arthralgia, beriberi, edema, fidgets due to deficiency, throbs with fear, forgetful, urinary obstruction, reddish and whitish turbid urine." removing heat from blood is except steaming, lung heat clearing pathogenic fire reducing.Cure mainly hectic fever due to deficiency of YIN, hectic fever due to YIN-deficiency night sweat, infantile malnutrition heating, quenches one's thirst, and pulmonary cough is breathed heavily, spits blood, epistaxis, hematuria.Modern times are used for the treatment of hypertension, flat wart, palmoplantar verruca, universal eczema, pulpitis pain etc.
Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi): bitter in the mouth; Puckery; Property is put down.Return stomach; Spleen; Large intestine channel.Function cures mainly: heat-clearing and toxic substances removing; Removing dampness to relieve itching.Main Resina Toxicodendri verniciflui allergy; Paddy field dermatitis; Skin pruritus; Urticaria; Eczema; Burn; Mastitis; Acute gastroenteritis; Dysentery.
Semen Persicae: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea , WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Fructus Viticis: pungent, bitter, be slightly cold.Return bladder, liver, stomach warp.Function cures mainly: dispelling wind and heat pathogens, the clear sharp head.For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.
Concha Arcae: expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.For the long-pending knot of pertinacious phlegm, thickness difficulty is coughed up, goiter, scrofula, abdominal mass mass in the abdomen, stomachache pantothenic acid.Three is salty in the mouth all, all can eliminating phlegm and softening indurated mass eliminating stagnation, and with cards such as the available goiter of controlling phlegm-fire pent-up, scrofula, sucutaneous nodule.Wherein, Concha Meretricis seu Cyclinae and Pumex again can removing heat from the lung and dissipating phlegm, the available cough and asthma of controlling lung-heat, phlegm-fire again, the yellow thickness person of expectorant; And Concha Meretricis seu Cyclinae and Concha Arcae can relieving gastric hyperacidity to alleviate stomachaches, with the acid regurgitation for the treatment of for stomachache.
Radix Salviae Miltiorrhizae: there is promoting blood circulation to remove blood stasis, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving, coronary artery dilator, improve myocardial ischemia situation, with all worries set aside, blood sugar lowering and the effect such as antibacterial reduce blood pressure, calm the nerves, to menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the diseases such as angina pectoris have certain curative effect.In addition, modern medicine experiment showed, that Radix Salviae Miltiorrhizae also has the function of anti-platelet aggregation, reduction blood viscosity and the inside and outside blood coagulation system of adjusting, is the natural Chinese medicine that a kind of safety is treated again cardiovascular disease reliably.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.
Radix Aerio Fici Microcarpae: bitter in the mouth, property are put down.Return lung; Spleen; Kidney channel.Function cures mainly: loose wind heat; Wind-damp dispelling; Promoting blood circulation and stopping pain.Main flow sense; Pertussis; Measles without adequate eruption; Tonsillitis; Conjunctivitis; Rheumatic ostalgia; Eruptive disease stomachache; Chronic dysentery; Stomachache; Leucorrhea; Eczema; Pudendal pruritus; Traumatic injury.
Calculus Bovis: sweet, cool.GUIXIN, Liver Channel.Function cures mainly: clear away heart-fire, eliminating phlegm, has one's ideas straightened out, cool liver, endogenous wind stopping, removing toxic substances.For calentura coma, middle wind-phlegm fan, infantile convulsion is twitched, and epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.
Borneolum Syntheticum: logical all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain, the loose poison of heat clearing away, loose fire removing toxic substances.Control mammary gland caking, apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.1. not " not Lu ": " married woman's difficult labour, gets Borneolum Syntheticum and grind a little into powder, newly to draw water and to be taken after mixing with liquid." 2. Tang Materia Medica: " main trusted subordinate's pathogen, rheumatism is gathered, deafness.Improving eyesight, goes conjunctival congestion skin nebula.External oculopathy eye in " 3. " Haiyao Bencao, Oversea Materia Medica ": " is main, three worms, control five hemorrhoid, improving eyesight, relieving palpitation, secret essence.It is de-that " 4. Zhang Yuansu: " controls large intestine." 5. Li Gao: " controls osteodynia." 6. Wang Haogu: " relieved boredom and filled heat." 7. " detailed outline ": " treats sore throat, headache, and breath, toothache, typhoid fever protrusion of the tongue, children's's pox falls into.Logical all keys, loose stagnated fire." 8. essentials of Matea Medica: " controls infantile convulsion expectorant fan." 9. " can approximately cure mirror ": " controls arthrodynia of extremities."
Mel: sweet in the mouth, property are put down.Spleen, stomach, lung, large intestine channel.Mel also has certain curative effect to some chronic disease.Informal dress Mel has good medical assistance effect for heart disease, hypertension, pneumonopathy, oculopathy, hepatopathy, dysentery, constipation, anemia, nervous system disease, gastric duodenal ulcer disease etc.High-quality Mel is at room temperature placed the several years can be not corrupt, shows that its antisepsis is extremely strong.Experiment confirmation, Mel has stronger inhibitory action to gram positive bacterias such as streptococcus, staphylococcus, diphtheria.Studies have shown that, Mel has regulating action to gastrointestinal function, can make gastric acid secretion normal.Zoopery confirmation, Mel has the effect that strengthens enterokinesia, can significantly shorten defecation time.
Sha Jiang: gas perfume (or spice) is special, and acrid in the mouth is peppery.Function cures mainly circulation of qi promoting warming middle-JIAO, helps digestion, and pain relieving.For chest and diaphragm distension, coldness and pain in the epigastrium, diet does not disappear.Husky Rhizoma Zingiberis Recens acrid in the mouth, warm in nature, enters stomach warp; The people trusted subordinate cold type of pain of suitable cold syndrome of the stomach, borborygmus diarrhoea person, poor appetite, anorexia, or it is edible to stop the people of dyspepsia.Compendium of Material Medica: " in warm, ward off communicable subtropical diseases bad odor, control trusted subordinate's cold type of pain, cold-damp cholera.", " book on Chinese herbal medicine converges and says ": " control and stop dyspepsia, all cards of all excessive cold invading middle-JIAO(the spleen and stomach) " has warming spleen and stomach for dispelling cold, appetite-stimulating indigestion-relieving, effect of regulating QI to relieve pain.
Fructus Luffae: sweet in the mouth; Cool in nature.Return lung; Liver; Stomach; Large intestine channel.Function cures mainly: removing heat-phlegm; Removing pathogenic heat from blood and toxic substance from the body.Main calentura fever of the body excessive thirst; Phlegm dyspnea cough; Discharging fresh blood stool, bleeding hemorrhoids; Stranguria with blood; Metrorrhagia; Ulcer sores; Galactostasis; Innominate toxic swelling; Edema.
Exocarpium Benincasae: sweet in the mouth, cold nature; Return lung meridian, spleen channel, small intestine meridian." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " quench the thirst, expectorant, diuresis.Control apoplexy." clearing away heat and promoting diuresis, detumescence.Cure mainly edema, dysuria, has loose bowels, and skin ulcer is swollen.This product is cool in nature, has the effect of clearing away summer-heat, thirsty for controlling summer summer-heat, oliguria with reddish urine.2 liang of non-renal edema reconvalescent Exocarpium Benincasae decocts for oral administration, and the 1000ml that drinks water, after taking medicine, in 2 hours, discharging urine amount significantly increases compared with matched group, between 2-4 hour, reduces compared with matched group.Human trial, these product 62g decocts as for 100ml oral, separately makes own control with water 100ml, proves diuresis.
Rhizoma Corydalis: pungent, bitter, temperature.Return liver, spleen channel.Invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
 
In described external used medicine, the parts by weight of each raw medicinal material are preferably: Radix Codonopsis 10-20 weight portion, Radix Astragali 10-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Herb Gynostemmae Pentaphylli 5-10 weight portion, Rhizoma Anemarrhenae 10-20 weight portion, Rhizoma Phragmitis 10-20 weight portion, Herba Lophatheri 5-15 weight portion, Fructus Forsythiae 10-20 weight portion, hair mouth label 10-20 weight portion, Rhizoma Fagopyri Dibotryis 5-15 weight portion, Usnea 5-15 weight portion, Radix Tinosporae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Folium Callicarpae Formosanae 10-20 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 5-9 weight portion, Aloe 15-25 weight portion, Cortex Moutan 10-20 weight portion, Radix Arnebiae (Radix Lithospermi) 5-10 weight portion, Radix Cynanchi Atrati 5-10 weight portion, Hydrargyri Oxydum Rubrum 10-20 weight portion, Cortex Lycii 10-20 weight portion, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 10-20 weight portion, Semen Persicae 10-20 weight portion, Fructus Viticis 10-20 weight portion, Concha Arcae 10-20 weight portion, Radix Salviae Miltiorrhizae 10-20 weight portion, Radix Aerio Fici Microcarpae 10-20 weight portion, Calculus Bovis 15-20 weight portion, Borneolum Syntheticum 15-25 weight portion and Mel 10-20 weight portion,
In described endo-medicine, the parts by weight of each raw medicinal material are preferably: Radix Ginseng 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 10-20 weight portion, Rhizoma Dioscoreae 10-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 5-15 weight portion, Herb Gynostemmae Pentaphylli 5-15 weight portion, Radix Rehmanniae Preparata 5-10 weight portion, Rhizoma Anemarrhenae 10-20 weight portion, Herba Lophatheri 10-20 weight portion, husky Rhizoma Zingiberis Recens 15-25 weight portion, Fructus Forsythiae 10-20 weight portion, Herba Sedi 5-10 weight portion, Rhizoma Fagopyri Dibotryis 10-15 weight portion, Caulis Sargentodoxae 10-15 weight portion, Radix Tinosporae 5-9 weight portion, Fructus Hippophae 10-15 weight portion, Fructus Luffae 10-20 weight portion, Exocarpium Benincasae 10-20 weight portion, Rhizoma Corydalis 10-20 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 5-9 weight portion, Radix Rumicis Japonici 10-20 weight portion, Cortex Moutan 10-15 weight portion, Radix Cynanchi Atrati 5-15 weight portion, Cortex Lycii 10-20 weight portion, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 5-15 weight portion, Semen Persicae 10-20 weight portion and Calculus Bovis 10-20 weight portion.
In described external used medicine, the parts by weight of each raw medicinal material can also be preferably: Radix Codonopsis 15 weight portions, the Radix Astragali 15 weight portions, Radix Et Caulis Acanthopanacis Senticosi 15 weight portions, Herb Gynostemmae Pentaphylli 7 weight portions, the Rhizoma Anemarrhenae 15 weight portions, Rhizoma Phragmitis 15 weight portions, Herba Lophatheri 8 weight portions, Fructus Forsythiae 15 weight portions, hair mouth label 15 weight portions, Rhizoma Fagopyri Dibotryis 11 weight portions, Usnea 10 weight portions, Radix Tinosporae 8 weight portions, Fructus Hippophae 15 weight portions, Folium Callicarpae Formosanae 15 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 7 weight portions, Aloe 21 weight portions, Cortex Moutan 15 weight portions, Radix Arnebiae (Radix Lithospermi) 8 weight portions, Radix Cynanchi Atrati 7 weight portions, Hydrargyri Oxydum Rubrum 15 weight portions, Cortex Lycii 15 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15 weight portions, Semen Persicae 15 weight portions, Fructus Viticis 15 weight portions, Concha Arcae 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Radix Aerio Fici Microcarpae 15 weight portions, Calculus Bovis 18 weight portions, Borneolum Syntheticum 20 weight portions and Mel 15 weight portions,
In described endo-medicine, the parts by weight of each raw medicinal material can also be preferably: Radix Ginseng 15 weight portions, Radix Codonopsis 15 weight portions, the Radix Astragali 15 weight portions, Rhizoma Dioscoreae 15 weight portions, Radix Et Caulis Acanthopanacis Senticosi 7 weight portions, Herb Gynostemmae Pentaphylli 8 weight portions, Radix Rehmanniae Preparata 7 weight portions, the Rhizoma Anemarrhenae 15 weight portions, Herba Lophatheri 15 weight portions, husky Rhizoma Zingiberis Recens 21 weight portions, Fructus Forsythiae 15 weight portions, Herba Sedi 7 weight portions, Rhizoma Fagopyri Dibotryis 12 weight portions, Caulis Sargentodoxae 12 weight portions, Radix Tinosporae 6 weight portions, Fructus Hippophae 12 weight portions, Fructus Luffae 15 weight portions, Exocarpium Benincasae 15 weight portions, Rhizoma Corydalis 15 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 7 weight portions, Radix Rumicis Japonici 15 weight portions, Cortex Moutan 12 weight portions, Radix Cynanchi Atrati 8 weight portions, Cortex Lycii 15 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 7 weight portions, Semen Persicae 15 weight portions and Calculus Bovis 15 weight portions.
In described external used medicine, the parts by weight of each raw medicinal material can be preferably again: Radix Codonopsis 10 weight portions, the Radix Astragali 10 weight portions, Radix Et Caulis Acanthopanacis Senticosi 10 weight portions, Herb Gynostemmae Pentaphylli 5 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Rhizoma Phragmitis 20 weight portions, Herba Lophatheri 5 weight portions, Fructus Forsythiae 10 weight portions, hair mouth label 20 weight portions, Rhizoma Fagopyri Dibotryis 5 weight portions, Usnea 15 weight portions, Radix Tinosporae 5 weight portions, Fructus Hippophae 10 weight portions, Folium Callicarpae Formosanae 20 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 9 weight portions, Aloe 25 weight portions, Cortex Moutan 20 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Radix Cynanchi Atrati 5 weight portions, Hydrargyri Oxydum Rubrum 20 weight portions, Cortex Lycii 20 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 20 weight portions, Semen Persicae 10 weight portions, Concha Arcae 15 weight portions, Fructus Viticis 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Radix Aerio Fici Microcarpae 15 weight portions, Calculus Bovis 15 weight portions, Borneolum Syntheticum 15 weight portions and Mel 10 weight portions,
In described endo-medicine, the parts by weight of each raw medicinal material can be preferably again: Radix Ginseng 20 weight portions, Radix Codonopsis 20 weight portions, the Radix Astragali 20 weight portions, Rhizoma Dioscoreae 20 weight portions, Radix Et Caulis Acanthopanacis Senticosi 5 weight portions, Herb Gynostemmae Pentaphylli 5 weight portions, Radix Rehmanniae Preparata 10 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Herba Lophatheri 10 weight portions, husky Rhizoma Zingiberis Recens 15 weight portions, Fructus Forsythiae 20 weight portions, Herba Sedi 10 weight portions, Rhizoma Fagopyri Dibotryis 15 weight portions, Caulis Sargentodoxae 10 weight portions, Radix Tinosporae 5 weight portions, Fructus Hippophae 10 weight portions, Fructus Luffae 20 weight portions, Exocarpium Benincasae 20 weight portions, Rhizoma Corydalis 10 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 5 weight portions, Radix Rumicis Japonici 10 weight portions, Cortex Moutan 15 weight portions, Radix Cynanchi Atrati 5 weight portions, Cortex Lycii 10 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15 weight portions, Semen Persicae 20 weight portions and Calculus Bovis 10 weight portions.
In the time that the dosage form of external used medicine is ointment, its preparation method comprises: get the described parts by weight except Borneolum Syntheticum and Mel raw medicinal material mix after in water, soak 1-2 hour, then be placed in multi-function extractor, decoct for the first time amount of water and be mix medical material weight 5-10 doubly, decoct, while being heated to 100 DEG C, start timing, micro-boiling after 2 hours, filters and emits medicinal liquid from feed opening, puts in fluid reservoir; Decoct for the second time, amount of water is that the 5-10 that mixes medical material weight doubly measures, and is heated to 100 DEG C, and micro-boiling after 2 hours, extracts medicinal liquid out, merges with the medicinal liquid decocting for the first time; By merging in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the extractum that temperature to 60 is DEG C-70 DEG C is cooling; Rear Borneolum Syntheticum pulverizing and Mel are added in extractum to tinning after ultraviolet radiation sterilizing.
In the time that the dosage form of endo-medicine is capsule, its preparation method comprises:
A. described raw medicinal material is put into pulverizer grinding and sieving;
B. particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times;
C. get again the medicinal residues after above-mentioned ethanol extraction, the heating and refluxing extraction that adds water 2 times;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying are dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
Wherein, in described step a, described raw medicinal material is put into after pulverizer is pulverized and crossed 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%~40%, collects by the raw material fine powder of 120 mesh sieves for subsequent use;
In described step b, particulate matter remaining after sieving is put into the ethanol heating and refluxing extraction 2 times that ratio of weight and number is 5~7 times of amounts, each 1~2 hour, 2 extracting solution are merged and left standstill; In described step c, it is 5~7 times of water gaging heating and refluxing extraction 2 times that the medicinal residues that above-mentioned ethanol extraction is crossed add ratio of weight and number, each 1~2 hour, 2 extracting solution is merged and is left standstill;
In described steps d, above-mentioned two kinds of extracting solution are merged, the filtrate of 1.38 o'clock when concentrating under reduced pressure relative density is 50 DEG C~60 DEG C, reclaims ethanol, and gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of crossing spray dryer shower nozzle is 4kg/m 2, hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and incapsulated with raw material medicated powder.
In the time that the dosage form of endo-medicine is tablet, its preparation method comprises:
The first step, is mixed in proportion described each raw medicinal material, the ethanol that to add with respect to the determining alcohol of 4~5 times of mixture qualities be 85%~90%, and reflux 2~4 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 90%~95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 2~3 times of described medicinal residues quality again, reflux 1~3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2~3 hours, pulverizes, and sieves, and obtains 300 order~400 object micropowders;
The 3rd step, the micropowders that second step is obtained, add with respect to the microcrystalline Cellulose of 0.1~0.3 times of its quality, 0.15~0.3 times of lactose, the starch of 0.2~0.35 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.025~0.04 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
 
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
 
Embodiment 1 ointment
The embodiment of the present invention provides a kind of external used medicine of the burn that is used for the treatment of QI and blood deficiency, dosage form is ointment, the parts by weight of its each raw medicinal material are: Radix Codonopsis 15 weight portions, the Radix Astragali 15 weight portions, Radix Et Caulis Acanthopanacis Senticosi 15 weight portions, Herb Gynostemmae Pentaphylli 7 weight portions, the Rhizoma Anemarrhenae 15 weight portions, Rhizoma Phragmitis 15 weight portions, Herba Lophatheri 8 weight portions, Fructus Forsythiae 15 weight portions, hair mouth label 15 weight portions, Rhizoma Fagopyri Dibotryis 11 weight portions, Usnea 10 weight portions, Radix Tinosporae 8 weight portions, Fructus Hippophae 15 weight portions, Folium Callicarpae Formosanae 15 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 7 weight portions, Aloe 21 weight portions, Cortex Moutan 15 weight portions, Radix Arnebiae (Radix Lithospermi) 8 weight portions, Radix Cynanchi Atrati 7 weight portions, Hydrargyri Oxydum Rubrum 15 weight portions, Cortex Lycii 15 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15 weight portions, Semen Persicae 15 weight portions, Fructus Viticis 15 weight portions, Concha Arcae 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Radix Aerio Fici Microcarpae 15 weight portions, Calculus Bovis 18 weight portions, Borneolum Syntheticum 20 weight portions and Mel 15 weight portions,
Its preparation method comprises: get the described parts by weight except Borneolum Syntheticum and Mel raw medicinal material mix after in water, soak 2 hours, then be placed in multi-function extractor, decoct for the first time amount of water and be and mix 8 times of medical material weight, decoct, while being heated to 100 DEG C, start timing, micro-boiling after 2 hours, filter and emit medicinal liquid from feed opening, put in fluid reservoir; Decoct for the second time, amount of water is 6 times of amounts of mixing medical material weight, is heated to 100 DEG C, and micro-boiling after 2 hours extracted medicinal liquid out, merges with the medicinal liquid decocting for the first time; By merging in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.05MPa, temperature remains on 70 DEG C, and being concentrated into relative density is 1.20, and the extractum of temperature to 65 DEG C is cooling; Rear Borneolum Syntheticum pulverizing and Mel are added in extractum to tinning after ultraviolet radiation sterilizing.
 
Embodiment 2 tinctures
The embodiment of the present invention provides a kind of external used medicine of the burn that is used for the treatment of QI and blood deficiency, dosage form is tincture, the parts by weight of its each raw medicinal material are: Radix Codonopsis 10 weight portions, the Radix Astragali 10 weight portions, Radix Et Caulis Acanthopanacis Senticosi 10 weight portions, Herb Gynostemmae Pentaphylli 5 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Rhizoma Phragmitis 20 weight portions, Herba Lophatheri 5 weight portions, Fructus Forsythiae 10 weight portions, hair mouth label 20 weight portions, Rhizoma Fagopyri Dibotryis 5 weight portions, Usnea 15 weight portions, Radix Tinosporae 5 weight portions, Fructus Hippophae 10 weight portions, Folium Callicarpae Formosanae 20 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 9 weight portions, Aloe 25 weight portions, Cortex Moutan 20 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Radix Cynanchi Atrati 5 weight portions, Hydrargyri Oxydum Rubrum 20 weight portions, Cortex Lycii 20 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 20 weight portions, Semen Persicae 10 weight portions, Concha Arcae 15 weight portions, Fructus Viticis 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Radix Aerio Fici Microcarpae 15 weight portions, Calculus Bovis 15 weight portions, Borneolum Syntheticum 15 weight portions and Mel 10 weight portions,
The first step, is mixed in proportion all the other raw medicinal materials except Mel and Borneolum Syntheticum, adds the water of 7 times of amounts, decoct 3 times, each 2 hours, each time decoction liquor was filtered, merge filtrate each time, adding determining alcohol is that 90% ethanol to alcohol content is 45%, leaves standstill 4 hours, filter, filtrate is concentrated, is dried and pulverizes, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 2 hours;
Second step, the mixed-powder that the first step is obtained joins the ethanol that the determining alcohol of 2 times of quality is 75%, airtight placement 36h, moistening even, be placed in percolation vat, after the ethanol that the determining alcohol that again adds the 1 times of quality of mixed-powder obtaining with respect to second step is 75%, place 36h, with the diafiltration of 4ml/min speed, collect percolate; Extrude the medicinal liquid of balance in percolation vat, merge with above-mentioned percolate, leave standstill, clarified supernatant, is dissolved in Mel and Borneolum Syntheticum in supernatant, filters, and concentrated, solution is brown color, and crude drug concentration is 2g/ml.
 
Embodiment 3 capsules
The embodiment of the present invention provides a kind of endo-medicine of the burn that is used for the treatment of QI and blood deficiency, dosage form is capsule, the parts by weight of its each raw medicinal material are: Radix Ginseng 15 weight portions, Radix Codonopsis 15 weight portions, the Radix Astragali 15 weight portions, Rhizoma Dioscoreae 15 weight portions, Radix Et Caulis Acanthopanacis Senticosi 7 weight portions, Herb Gynostemmae Pentaphylli 8 weight portions, Radix Rehmanniae Preparata 7 weight portions, the Rhizoma Anemarrhenae 15 weight portions, Herba Lophatheri 15 weight portions, husky Rhizoma Zingiberis Recens 21 weight portions, Fructus Forsythiae 15 weight portions, Herba Sedi 7 weight portions, Rhizoma Fagopyri Dibotryis 12 weight portions, Caulis Sargentodoxae 12 weight portions, Radix Tinosporae 6 weight portions, Fructus Hippophae 12 weight portions, Fructus Luffae 15 weight portions, Exocarpium Benincasae 15 weight portions, Rhizoma Corydalis 15 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 7 weight portions, Radix Rumicis Japonici 15 weight portions, Cortex Moutan 12 weight portions, Radix Cynanchi Atrati 8 weight portions, Cortex Lycii 15 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 7 weight portions, Semen Persicae 15 weight portions and Calculus Bovis 15 weight portions.
Its preparation method comprises:
A. described raw medicinal material is put into after pulverizer is pulverized and crossed 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 35%, collects by the raw material fine powder of 120 mesh sieves for subsequent use;
B. the ethanol heating and refluxing extraction 2 times of particulate matter remaining after sieving being put into ratio of weight and number and be 6 times of amounts, each 2 hours, merges 2 extracting solution to leave standstill;
C. it is 6 times of water gaging heating and refluxing extraction 2 times that the medicinal residues of above-mentioned ethanol extraction being crossed add ratio of weight and number, each 1.5 hours, 2 extracting solution is merged and is left standstill;
D. above-mentioned two kinds of extracting solution are merged, the filtrate of 1.38 o'clock when concentrating under reduced pressure relative density is 55 DEG C, reclaims ethanol, and gained filtrate is adjusted to proportion to 1.06, pass into spray dryer spray dry, the compressed air pressure of spray dryer shower nozzle be 4kg/m 2, hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and incapsulated with raw material medicated powder.
 
Embodiment 4 tablets
The embodiment of the present invention provides a kind of endo-medicine of the burn that is used for the treatment of QI and blood deficiency, dosage form is tablet, the parts by weight of its each raw medicinal material are: Radix Ginseng 20 weight portions, Radix Codonopsis 20 weight portions, the Radix Astragali 20 weight portions, Rhizoma Dioscoreae 20 weight portions, Radix Et Caulis Acanthopanacis Senticosi 5 weight portions, Herb Gynostemmae Pentaphylli 5 weight portions, Radix Rehmanniae Preparata 10 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Herba Lophatheri 10 weight portions, husky Rhizoma Zingiberis Recens 15 weight portions, Fructus Forsythiae 20 weight portions, Herba Sedi 10 weight portions, Rhizoma Fagopyri Dibotryis 15 weight portions, Caulis Sargentodoxae 10 weight portions, Radix Tinosporae 5 weight portions, Fructus Hippophae 10 weight portions, Fructus Luffae 20 weight portions, Exocarpium Benincasae 20 weight portions, Rhizoma Corydalis 10 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 5 weight portions, Radix Rumicis Japonici 10 weight portions, Cortex Moutan 15 weight portions, Radix Cynanchi Atrati 5 weight portions, Cortex Lycii 10 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15 weight portions, Semen Persicae 20 weight portions and Calculus Bovis 10 weight portions.
In the time that the dosage form of endo-medicine is tablet, its preparation method comprises:
The first step, is mixed in proportion described each raw medicinal material, the ethanol that to add with respect to the determining alcohol of 4 times of mixture qualities be 85%, and reflux 3 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 90% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 2.5 times of described medicinal residues quality again, reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2.5 hours, pulverizes, and sieves, and obtains 350 object micropowders;
The 3rd step, the micropowders that second step is obtained, adds with respect to the microcrystalline Cellulose of 0.2 times of its quality, 0.2 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds with respect to 0.03 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
 
Toxicity test
1,40 of application NIH mices, SPF level, male and female half and half, body weight 18~22g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, i.e. matched group and administration group, fasting 12 hours before experiment; Tablet dissolved prepared by embodiments of the invention 4 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet LD50>32.9 of the present invention crude drug/kg, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.4g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is taking 20g) oral administration gavage Chinese medicine of the present invention is 901 times of quantity.Therefore tablet acute toxicity of the present invention is low, clinical drug safety.
2, by the capsule of the embodiment of the present invention 3 to mice by 7.81,18.34 and 12 weeks (1.0ml/100g body weight of 40.11g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of Chinese medicine preparation of the present invention to mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after capsule of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
3,20 of SD rats, male and female half and half, body weight 90g~180g, percutaneous of liniment that the embodiment of the present invention 2 is obtained is smeared 5000mg/kg body weight dosage, observe 15 days, do not find obvious poisoning symptom, nothing death, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.
4, get 18 of healthy albino guinea-pigs, body weight 250-300g, male and female dual-purpose, rejects both sides dorsal body setae before test, and every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.The ointment 0.1g that gets the embodiment of the present invention 1 is applied to unhairing district, back, the next day 1 time, totally 3 times.Contact latter 14 days in last, smear this product 0.1g at back the same area, after 6h, remove after medicine and at once observe, and in 24,48,72h observes and has or not anaphylaxis.Blank group is used same method to excite with positive controls and is contacted and observe.Result of the test: localized erythema and slight edema appear in positive controls animal skin after 1 hour in sensitization, within 24 hours, symptoms of allergic increases the weight of, and there is scleroma to form, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.
5, medicine of the present invention is scalded test to rabbit, and concrete condition and result of the test are as follows:
(1) material
1, medicine preparation: get 3 grams of the ointments of the embodiment of the present invention 1, be adjusted to 10ml with distilled water and be coated with wound outward.
2, contrast medicine: 1 20g of JINGWANHONG burn cream.
3, depilatory: 8% sodium sulfide solution:
4, animal: certain medical college experimental animal center provides 9.
(2) method and result
Get 9 of rabbits, body weight 1.75-1.9 kilogram, male and female dual-purpose, cropping under the buttocks of every rabbit and left and right rib, slough hair with depilatory, finish position and area, and use the standardized " # " font of scalpel wound at the position of finishing, size is 3 × 2cm, the degree of depth, for scratching skin corium, till oozing of blood, is then injected medical ethanol with cotton balls, be placed in " # " and light 1.5min, area 3 × 3cm.3 positions of every rabbit burn, 1 position is coated with JINGWANHONG burn cream, and a position is coated with medicine of the present invention, and what is not coated with the harmony of accomplishing test for position, and a position for burn point each medicine coating arranges by Latin mode.
Grouping: medicine group of the present invention, matched group, blank group (what is not coated with).Three groups of nine every three components of rabbit, one group of rabbit is I degree burn, and one group of rabbit is II degree burn, and also having one group of rabbit is III degree burn, and after burn, medication 15 days, observes wound situation every day, (suppurate, the situation of downright bad, fur growth etc.).After last coating second day, cleans wound, observes wound growing state.Carry out result statistics with scoring method.Long new skin is 40 points, and endysising is 20 points, is 20 points without incrustation, is 20 points without suppurating.Observed result finds that medicine burned part wound of the present invention heals completely, and the wound diameter that is coated with JINGWANHONG burn cream dwindles, and the wound of blank group have fester, suppuration, downright bad phenomenon.In table 1.
The impact (X ± S) of table 1 medicine of the present invention on scald property rabbit
Group Wound number (individual) Wound healing after medication (%)
Blank group 9 ?33.01±22.51
JINGWANHONG burn cream group 9 72.31±11.15
Drug powder group of the present invention 9 ?95.72±10.72
From result of the test, medicine of the present invention has positive effect to rabbits burned wound healing, tool significance.
 
Clinical trial
Case selection: be selected from May, 2009-2012 Lai Wo institute Department of B urn Patients with 300 Cases patient in year April, man's 186 examples, female's 114 examples, age 8-68 year, 29.5 years old mean age, traumatogenic reason is in the majority with hydrothermal solution and flame burn and scald, be respectively 147 example and 98 examples, next for electric burn be 28 examples, chemical burn 21 examples and hot solids 6 examples of burning, burn surface area light degree Ⅱ area≤15% 148 example, dark II degree area≤30% 116 example, III degree area >=60% 36 example.300 routine patients all in various degree there is following symptom: low grade fever or do not generate heat, spiritlessness and weakness, inappetence, emaciated physique, lustreless complexion, wound surface granulation color is light, is difficult to healing; Light red tongue, white and thin fur, thready and weak pulse.300 routine patients are divided into three groups at random, and every group of 100 examples, are respectively embodiment group 1, embodiment group 2 and matched group, and each experimental group case is equal no significant difference aspect age, sex, traumatogenic reason, burn surface area, the degree of depth, position and the traumatic condition order of severity.
Therapeutic Method:
Embodiment group 1: use the ointment of the embodiment of the present invention 1 and the capsule of embodiment 3 to treat simultaneously, be applied to affected part after ointment debridement, every 6-8h changes medicine one time, capsule every day three times, each 3 seven days is a course for the treatment of, treats continuously 2-12 the course for the treatment of;
Embodiment group 2: use the liniment of the embodiment of the present invention 2 and the tablet of embodiment 4 to treat simultaneously, be applied to affected part after liniment debridement, every 6-8h changes medicine one time, tablet every day three times, each 2 seven days is a course for the treatment of, treats continuously 2-12 the course for the treatment of;
Matched group: use MEIBAO SHIRUN SHAOSHANG GAO, smear affected part after debridement, every 4-6h changes medicine one time, patients with deep burn vein input cephalosporins.
Carry out sedation-analgesia according to the ailing demand of patient, Du makes fourth 1~2mg/kg, has dyspnea and craniocerebral trauma to be cautious use of.
Criterion of therapeutical effect: cure: wound surface all healed, without residual wound; Basic healing: wound surface heals substantially, and the 1% residual wound that still has some deficits, without operation, is changed dressings and can be healed through a period of time; Take a turn for the better: the healing of the large portion of wound surface, but residual wound surface exceedes more than 1%, the surgery skin grafting of still needing; Do not heal: wound surface is most of to be existed.Wherein, effective percentage is cure rate and basic cure rate sum.
Efficacy result:
Referring to table 1 and table 2, as can be seen from Table 1, adopt medicine composite for curing QIXUELIANGXU type burn of the present invention, be equivalent to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt medicine composite for curing QIXUELIANGXU type burn of the present invention, with respect to conventional medicament, treating significantly shortening on the course for the treatment of.
The each experimental group of table 1 is treated respectively Clinical efficacy comparison example after 2-12 the course for the treatment of
Group Number of cases Cure Basic healing Take a turn for the better Do not heal Effective percentage
Embodiment group 1 100 48 32 19 1 80%
Embodiment group 2 100 45 33 20 2 78%
Matched group 100 38 21 32 9 59%
The each experimental group of table 2 is treated respectively rear healing and basic healing number and time comparative example (%)
Group Number of cases 2-4 the course for the treatment of 5-8 the course for the treatment of 9-12 the course for the treatment of
Embodiment group 1 80 20(25.0%) 34(42.5%) 26(32.5%)
Embodiment group 2 78 18(23.1%) 33(42.3%) 27(34.6%)
Matched group 59 11(18.6%) 20(33.9%) 28(47.5%)
Known according to the clinical statistics in above table, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect.
 
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (10)

1. be used for the treatment of the pharmaceutical composition of QIXUELIANGXU type burn, it is characterized in that, comprise endo-medicine and external used medicine, described external used medicine comprises following raw medicinal material: Radix Codonopsis, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, Herba Lophatheri, Fructus Forsythiae, hair mouth label, Rhizoma Fagopyri Dibotryis, Usnea, Radix Tinosporae, Fructus Hippophae, Folium Callicarpae Formosanae, Ilex purpurea Hassk.[I.chinensis Sims, Aloe, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Cynanchi Atrati, Hydrargyri Oxydum Rubrum, Cortex Lycii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Semen Persicae, Fructus Viticis, Concha Arcae, Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Calculus Bovis, Borneolum Syntheticum and Mel;
Described endo-medicine comprises following raw medicinal material: Radix Ginseng, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Herb Gynostemmae Pentaphylli, Radix Rehmanniae Preparata, the Rhizoma Anemarrhenae, Herba Lophatheri, Sha Jiang, Fructus Forsythiae, Herba Sedi, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae, Radix Tinosporae, Fructus Hippophae, Fructus Luffae, Exocarpium Benincasae, Rhizoma Corydalis, Ilex purpurea Hassk.[I.chinensis Sims, Radix Rumicis Japonici, Cortex Moutan, Radix Cynanchi Atrati, Cortex Lycii, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi), Semen Persicae and Calculus Bovis.
2. the pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn according to claim 1, is characterized in that, in described external used medicine, the parts by weight of each raw medicinal material are: Radix Codonopsis 10-20 weight portion, Radix Astragali 10-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Herb Gynostemmae Pentaphylli 5-10 weight portion, Rhizoma Anemarrhenae 10-20 weight portion, Rhizoma Phragmitis 10-20 weight portion, Herba Lophatheri 5-15 weight portion, Fructus Forsythiae 10-20 weight portion, hair mouth label 10-20 weight portion, Rhizoma Fagopyri Dibotryis 5-15 weight portion, Usnea 5-15 weight portion, Radix Tinosporae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Folium Callicarpae Formosanae 10-20 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 5-9 weight portion, Aloe 15-25 weight portion, Cortex Moutan 10-20 weight portion, Radix Arnebiae (Radix Lithospermi) 5-10 weight portion, Radix Cynanchi Atrati 5-10 weight portion, Hydrargyri Oxydum Rubrum 10-20 weight portion, Cortex Lycii 10-20 weight portion, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 10-20 weight portion, Semen Persicae 10-20 weight portion, Fructus Viticis 10-20 weight portion, Concha Arcae 10-20 weight portion, Radix Salviae Miltiorrhizae 10-20 weight portion, Radix Aerio Fici Microcarpae 10-20 weight portion, Calculus Bovis 15-20 weight portion, Borneolum Syntheticum 15-25 weight portion and Mel 10-20 weight portion,
In described endo-medicine, the parts by weight of each raw medicinal material are: Radix Ginseng 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 10-20 weight portion, Rhizoma Dioscoreae 10-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 5-15 weight portion, Herb Gynostemmae Pentaphylli 5-15 weight portion, Radix Rehmanniae Preparata 5-10 weight portion, Rhizoma Anemarrhenae 10-20 weight portion, Herba Lophatheri 10-20 weight portion, husky Rhizoma Zingiberis Recens 15-25 weight portion, Fructus Forsythiae 10-20 weight portion, Herba Sedi 5-10 weight portion, Rhizoma Fagopyri Dibotryis 10-15 weight portion, Caulis Sargentodoxae 10-15 weight portion, Radix Tinosporae 5-9 weight portion, Fructus Hippophae 10-15 weight portion, Fructus Luffae 10-20 weight portion, Exocarpium Benincasae 10-20 weight portion, Rhizoma Corydalis 10-20 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 5-9 weight portion, Radix Rumicis Japonici 10-20 weight portion, Cortex Moutan 10-15 weight portion, Radix Cynanchi Atrati 5-15 weight portion, Cortex Lycii 10-20 weight portion, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 5-15 weight portion, Semen Persicae 10-20 weight portion and Calculus Bovis 10-20 weight portion.
3. the pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn according to claim 1 and 2, it is characterized in that, in described external used medicine, the parts by weight of each raw medicinal material are: Radix Codonopsis 15 weight portions, the Radix Astragali 15 weight portions, Radix Et Caulis Acanthopanacis Senticosi 15 weight portions, Herb Gynostemmae Pentaphylli 7 weight portions, the Rhizoma Anemarrhenae 15 weight portions, Rhizoma Phragmitis 15 weight portions, Herba Lophatheri 8 weight portions, Fructus Forsythiae 15 weight portions, hair mouth label 15 weight portions, Rhizoma Fagopyri Dibotryis 11 weight portions, Usnea 10 weight portions, Radix Tinosporae 8 weight portions, Fructus Hippophae 15 weight portions, Folium Callicarpae Formosanae 15 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 7 weight portions, Aloe 21 weight portions, Cortex Moutan 15 weight portions, Radix Arnebiae (Radix Lithospermi) 8 weight portions, Radix Cynanchi Atrati 7 weight portions, Hydrargyri Oxydum Rubrum 15 weight portions, Cortex Lycii 15 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15 weight portions, Semen Persicae 15 weight portions, Fructus Viticis 15 weight portions, Concha Arcae 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Radix Aerio Fici Microcarpae 15 weight portions, Calculus Bovis 18 weight portions, Borneolum Syntheticum 20 weight portions and Mel 15 weight portions,
In described endo-medicine, the parts by weight of each raw medicinal material are: Radix Ginseng 15 weight portions, Radix Codonopsis 15 weight portions, the Radix Astragali 15 weight portions, Rhizoma Dioscoreae 15 weight portions, Radix Et Caulis Acanthopanacis Senticosi 7 weight portions, Herb Gynostemmae Pentaphylli 8 weight portions, Radix Rehmanniae Preparata 7 weight portions, the Rhizoma Anemarrhenae 15 weight portions, Herba Lophatheri 15 weight portions, husky Rhizoma Zingiberis Recens 21 weight portions, Fructus Forsythiae 15 weight portions, Herba Sedi 7 weight portions, Rhizoma Fagopyri Dibotryis 12 weight portions, Caulis Sargentodoxae 12 weight portions, Radix Tinosporae 6 weight portions, Fructus Hippophae 12 weight portions, Fructus Luffae 15 weight portions, Exocarpium Benincasae 15 weight portions, Rhizoma Corydalis 15 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 7 weight portions, Radix Rumicis Japonici 15 weight portions, Cortex Moutan 12 weight portions, Radix Cynanchi Atrati 8 weight portions, Cortex Lycii 15 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 7 weight portions, Semen Persicae 15 weight portions and Calculus Bovis 15 weight portions.
4. according to the pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn described in claim 1-3 any one, it is characterized in that, in described external used medicine, the parts by weight of each raw medicinal material are: Radix Codonopsis 10 weight portions, the Radix Astragali 10 weight portions, Radix Et Caulis Acanthopanacis Senticosi 10 weight portions, Herb Gynostemmae Pentaphylli 5 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Rhizoma Phragmitis 20 weight portions, Herba Lophatheri 5 weight portions, Fructus Forsythiae 10 weight portions, hair mouth label 20 weight portions, Rhizoma Fagopyri Dibotryis 5 weight portions, Usnea 15 weight portions, Radix Tinosporae 5 weight portions, Fructus Hippophae 10 weight portions, Folium Callicarpae Formosanae 20 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 9 weight portions, Aloe 25 weight portions, Cortex Moutan 20 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Radix Cynanchi Atrati 5 weight portions, Hydrargyri Oxydum Rubrum 20 weight portions, Cortex Lycii 20 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 20 weight portions, Semen Persicae 10 weight portions, Concha Arcae 15 weight portions, Fructus Viticis 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Radix Aerio Fici Microcarpae 15 weight portions, Calculus Bovis 15 weight portions, Borneolum Syntheticum 15 weight portions and Mel 10 weight portions,
In described endo-medicine, the parts by weight of each raw medicinal material are: Radix Ginseng 20 weight portions, Radix Codonopsis 20 weight portions, the Radix Astragali 20 weight portions, Rhizoma Dioscoreae 20 weight portions, Radix Et Caulis Acanthopanacis Senticosi 5 weight portions, Herb Gynostemmae Pentaphylli 5 weight portions, Radix Rehmanniae Preparata 10 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Herba Lophatheri 10 weight portions, husky Rhizoma Zingiberis Recens 15 weight portions, Fructus Forsythiae 20 weight portions, Herba Sedi 10 weight portions, Rhizoma Fagopyri Dibotryis 15 weight portions, Caulis Sargentodoxae 10 weight portions, Radix Tinosporae 5 weight portions, Fructus Hippophae 10 weight portions, Fructus Luffae 20 weight portions, Exocarpium Benincasae 20 weight portions, Rhizoma Corydalis 10 weight portions, Ilex purpurea Hassk.[I.chinensis Sims 5 weight portions, Radix Rumicis Japonici 10 weight portions, Cortex Moutan 15 weight portions, Radix Cynanchi Atrati 5 weight portions, Cortex Lycii 10 weight portions, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15 weight portions, Semen Persicae 20 weight portions and Calculus Bovis 10 weight portions.
5. according to the preparation method of the pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn described in claim 1-4 any one, it is characterized in that, the dosage form of described external used medicine is ointment, its preparation method comprises: get the described parts by weight except Borneolum Syntheticum and Mel raw medicinal material mix after in water, soak 1-2 hour, then be placed in multi-function extractor, decoct for the first time amount of water and be mix medical material weight 5-10 doubly, decoct, while being heated to 100 DEG C, start timing, micro-boiling after 2 hours, filters and emits medicinal liquid from feed opening, puts in fluid reservoir; Decoct for the second time, amount of water is that the 5-10 that mixes medical material weight doubly measures, and is heated to 100 DEG C, and micro-boiling after 2 hours, extracts medicinal liquid out, merges with the medicinal liquid decocting for the first time; By merging in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the extractum that temperature to 60 is DEG C-70 DEG C is cooling; Rear Borneolum Syntheticum pulverizing and Mel are added in extractum to tinning after ultraviolet radiation sterilizing.
6. according to the preparation method of the pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn described in claim 1-5 any one, it is characterized in that, the dosage form of described endo-medicine is capsule, and its preparation method comprises:
A. described raw medicinal material is put into pulverizer grinding and sieving;
B. particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times;
C. get again the medicinal residues after above-mentioned ethanol extraction, the heating and refluxing extraction that adds water 2 times;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying are dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
7. the preparation method of the pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn according to claim 6, it is characterized in that, in described step a, described raw medicinal material is put into after pulverizer is pulverized and crossed 120 order dusting covers, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%~40%, collects by the raw material fine powder of 120 mesh sieves for subsequent use.
8. according to the preparation method of the pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn described in claim 6 or 7, it is characterized in that, in described step b, particulate matter remaining after sieving is put into the ethanol heating and refluxing extraction 2 times that ratio of weight and number is 5~7 times of amounts, each 1~2 hour, 2 extracting solution are merged and left standstill; In described step c, it is 5~7 times of water gaging heating and refluxing extraction 2 times that the medicinal residues that above-mentioned ethanol extraction is crossed add ratio of weight and number, each 1~2 hour, 2 extracting solution is merged and is left standstill.
9. according to the preparation method of the pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn described in claim 6-8 any one, it is characterized in that, in described steps d, above-mentioned two kinds of extracting solution are merged, the filtrate of 1.38 o'clock when concentrating under reduced pressure relative density is 50 DEG C~60 DEG C, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of mistake spray dryer shower nozzle is 4kg/m 2, hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and incapsulated with raw material medicated powder.
10. according to the preparation method of the pharmaceutical composition that is used for the treatment of QIXUELIANGXU type burn described in claim 1-5 any one, it is characterized in that, the dosage form of described endo-medicine is tablet, and its preparation method comprises:
The first step, is mixed in proportion described each raw medicinal material, the ethanol that to add with respect to the determining alcohol of 4~5 times of mixture qualities be 85%~90%, and reflux 2~4 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 90%~95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 2~3 times of described medicinal residues quality again, reflux 1~3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2~3 hours, pulverizes, and sieves, and obtains 300 order~400 object micropowders;
The 3rd step, the micropowders that second step is obtained, add with respect to the microcrystalline Cellulose of 0.1~0.3 times of its quality, 0.15~0.3 times of lactose, the starch of 0.2~0.35 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.025~0.04 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
CN201410195053.3A 2014-05-12 2014-05-12 Pharmaceutical composition for treating qi-blood deficiency burn, and preparation method thereof Pending CN103933405A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104689249A (en) * 2015-03-25 2015-06-10 魏玉娟 Medicine used for nursing and treating qi-blood deficiency burn and preparing method thereof
CN104840696A (en) * 2015-05-18 2015-08-19 中国人民解放军第四军医大学 Traditional Chinese medicine combination for treating qi and blood deficiency type burn
CN105267467A (en) * 2015-11-26 2016-01-27 付妍婕 Traditional Chinese medicinal preparation for treating burn and preparation method thereof
CN114404533A (en) * 2022-03-31 2022-04-29 江西纤仁本草堂生物科技有限公司 Medicine for treating burn and scald and its preparing process

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Publication number Priority date Publication date Assignee Title
JPS63255235A (en) * 1987-04-13 1988-10-21 Kozo Niwa Low-molecular vegetable antimalignant tumor agent
CN102885925A (en) * 2011-07-22 2013-01-23 刘金生 Chinese medicinal preparation for treating deficiency of qi and blood, qi stagnation and blood stasis
CN103479879A (en) * 2013-08-28 2014-01-01 严中明 Burn ointment and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63255235A (en) * 1987-04-13 1988-10-21 Kozo Niwa Low-molecular vegetable antimalignant tumor agent
CN102885925A (en) * 2011-07-22 2013-01-23 刘金生 Chinese medicinal preparation for treating deficiency of qi and blood, qi stagnation and blood stasis
CN103479879A (en) * 2013-08-28 2014-01-01 严中明 Burn ointment and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104689249A (en) * 2015-03-25 2015-06-10 魏玉娟 Medicine used for nursing and treating qi-blood deficiency burn and preparing method thereof
CN104840696A (en) * 2015-05-18 2015-08-19 中国人民解放军第四军医大学 Traditional Chinese medicine combination for treating qi and blood deficiency type burn
CN105267467A (en) * 2015-11-26 2016-01-27 付妍婕 Traditional Chinese medicinal preparation for treating burn and preparation method thereof
CN114404533A (en) * 2022-03-31 2022-04-29 江西纤仁本草堂生物科技有限公司 Medicine for treating burn and scald and its preparing process

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Application publication date: 20140723