CN104689249A

CN104689249A - Medicine used for nursing and treating qi-blood deficiency burn and preparing method thereof

Info

Publication number: CN104689249A
Application number: CN201510131021.1A
Authority: CN
Inventors: 魏玉娟
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-03-25
Filing date: 2015-03-25
Publication date: 2015-06-10

Abstract

The invention discloses medicine used for nursing and treating qi-blood deficiency burn and a preparing method thereof. Various raw materials in the medicine comprise the following materials: ventilago leiocarpa benth, longan aril, multi-edge ginseng, cistanche salsa, zedoary, Chinese-date, rex woodbetony, polygonum multiflorum, litchi, polygonatum odoratum, achyranthes bidentata, kalmegh, moellendorf's spidemoss herb, evodia lepta, indian kalimeris herb, lamiophlomis, herba fici, cortex albiziae, myrrh, nervilia fordii, negundo chastetree branchlet, helwingia leaf and fruit, agrimonia pilosa ledeb, pyrola, elaeagnus pungens, hyperforin perforatum, polygonum cuspidatum, red match, tonkin elm bark, folium sennae, trichosanthes kirilowii, fructus cannabis and liquorice. The medicine has the advantages that the qi and blood invigorating function is achieved, the nuring and treating of the qi-blood deficiency burn are achieved, the treatment is effective, the effect is fast, the anti-infection is achieved, the wound surface is prevented from spreading, the cytothesis and the skin healing ability are improved, the medicine feeding is convenient, the drug resistance is not likely to occur, the targeting is strong, and patients can easily accept.

Description

A kind of medicine for nursing for treating QIXUELIANGXU type burn and preparation method

Technical field

The present invention relates to pharmaceutical technology, particularly a kind of medicine for nursing for treating QIXUELIANGXU type burn and preparation method.

Background technology

Burn refers to the damage caused by flame, high-temp solid and intense radiation heat.Burn is the tissue injury caused by high temperature, chemical substance or electricity.Lactic acid production during burn in visible blood increases, and the pH value of arteriovenous blood reduces, and along with organizing, blood capillary is handicapped to be increased the weight of, and anoxemia also increases weight.Burn then can be in peril of one's life when reaching more than 1/3rd of total body surface area.

The cause of disease:

Direct contact high temp objects or be subject to caused by strong heat radiation, as heating power, chemical substance, electric energy, lonizing radiation etc.

Clinical manifestation:

The degree of burn is by the height of temperature, the length of action time and different.The order of severity of burn depends on scope and the degree of depth of wounded tissue, and depth of burn can be divided into I degree, II degree and III degree.Be specially:

I degree of burn injury is the lightest.Burned skin is rubescent, pain, obviously touch a tender spot, have and ooze out or edema.During light pressure injury, local bleaches, but does not have vesicle.

II degree of burn injury is darker.Skin blister.Take on a red color bottom vesicle or white, be filled with limpid, sticky liquid.Touch a tender spot responsive, bleach during compressing.

III degree of burn injury is the darkest.Burn surfaces can turn white, deliquescing or in black, carbonization hide-like.Owing to being become pale by burning skin, in pale skin people, be often mistaken as normal skin, but no longer variable color during compressing.The erythrocyte destroyed can make burn local skin be cerise, has vesicle once in a while, and the hair in burn district is easy to extract, and feels to go down.III degree of burn area does not generally have the pain sensation.Because the teleneuron of skin is destroyed.Burnt degree usually through in a few days, will could be distinguished dark II degree and burn with III degree.

Western medical treatment is burnt: minor burn should be immersed in cold water as far as possible immediately.A lot of fire victim needs the pain relieving of application analgesic.Life-threatening serious burn needs to treat immediately, and first-aid personnel applies face shield and cures by oxygen therapy to the wounded, to alleviate in fire carbon monoxide and toxic gas to the impact of the wounded.Patients with respiratory tract should be kept unobstructed, checked whether other life-threatening wounds, and liquid make-up and prevention infection.After wound surface is cleaned out, coating antimicrobial ointment or ointment, then cover with antiseptic gauze.Change gauze every day twice or thrice.Deep burn is easy to cause severe infections, answers vein to input antibiotic.If lower dermis damaged area is comparatively large, often need skin-grafting.

Western medical treatment burn need apply a large amount of antibiotic to prevent traumatic infection, diffusion, therefore easily produces drug resistance, and toxic and side effects is larger; Further, the quality of human immunoglobulin and lazy weight, cellular immune function are low, and effects of antibiotics is not satisfactory.

Chinese medicine thinks that burn is that pyretic toxicity people invade because heat-flash acts on human body, stagnation of QI-blood, and the lighter's skin and flesh rots, and severe one excessive noxious heat, injures cloudy liquid in body, or pyretic toxicity inside fire attack internal organs, so that internal organs are become estranged, imbalance of YIN and YANG.Traditional Chinese medical science burn is divided into following several types:

1, burning hot impairment of body fluid: heating, xerostomia wish drink, constipation, oliguria with reddish urine; Red tongue, yellow fur, rapid pulse.

2, cloudy impairment of YANG takes off: pale complexion, spiritlessness and weakness, and breath is low short, spontaneous perspiration and cold extremities, and body temperature is anti-low, drowsiness, very then staring spells; Deep red tongue or purple dark, no fur, thready pulse being about to disappear.

3, fire-toxin caves in: high fever excessive thirst or unconsciousness due to high fever, restlessness, xerocheilia, constipation, oliguria with reddish urine; Deep red tongue, thready and rapid pulse.

4, QI and blood deficiency: low grade fever or do not generate heat, spiritlessness and weakness, inappetence, emaciated physique, lustreless complexion, wound granulation color is light, is difficult to healing; Light red tongue, white and thin fur, thready and weak pulse.

5, weakness of the spleen and stomach: with the passing of time, wound surface is difficult to healing to the course of disease, fatigue and weak, inappetence, waist distention and fullness in the abdomen, or vomiting and diarrhoea, lustreless complexion, emaciated physique; Light red tongue, tongue is greasy in vain, weak pulse.

Chinese traditional treatment burn is based on organic conception, carry out interim determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs for burn in various degree, not only can improve animal economy immunity, promote the dynamic equilibrium such as Water-Electrolyte, and targeting is stronger, evident in efficacy, can infection, prevent wound surface from spreading, improve cytothesis, skin healing ability, not easily produce drug resistance, and cost price is cheap, patient is easy to accept.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of effect with benefiting vital QI and blood, holds concurrently with blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, astringing to arrest bleeding, the medicine of nursing for treating QIXUELIANGXU type burn.The present invention, based on organic conception, carries out interim determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs for burn in various degree, can improve animal economy immunity, promotes the dynamic equilibrium such as Water-Electrolyte, can infection, prevents wound surface from spread, raising cytothesis, skin healing ability.

In order to realize foregoing invention object, the invention provides a kind of medicine for nursing for treating QIXUELIANGXU type burn, described medicine comprises following raw medicinal material: Radix seu Caulis Verntilaginis Leiocarpae, Arillus Longan, Radix Glehniae, Herba Cistanches, Rhizoma Curcumae, Fructus Jujubae, Pedicularis rex C. B. Clarke ex Maxim., Radix Polygoni Multiflori, Fructus Litchi, Rhizoma Polygonati Odorati, Radix Achyranthis Bidentatae, Herba Andrographis, Herba Selaginellae Moellendorfii, Foliumet Ramulus Evodiae, Herba Kalimeridis, Radix Lamiophlomidis Rotatae, Caulis et Folium fici Tikouae, Cortex Albiziae, Myrrha, Folium Nerviliae fordii, Ramulus viticis negundo, Folium et Fructus Helwingiae, Herba Agrimoniae, Herba Pyrolae, Fructus Elaeagni, Herba Hyperici perforati, Rhizoma Polygoni Cuspidati, Bark of Lindenleaf Torricellia, Radix Ulmi Tonkinesis, Folium Sennae, Fructus Trichosanthis, Fructus Cannabis and Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix seu Caulis Verntilaginis Leiocarpae 10-15 part, Arillus Longan 12-19 part, Radix Glehniae 20-26 part, Herba Cistanches 16-27 part, Rhizoma Curcumae 10-18 part, Fructus Jujubae 15-25 part, Pedicularis rex C. B. Clarke ex Maxim. 12-22 part, Radix Polygoni Multiflori 20-28 part, Fructus Litchi 16-23 part, Rhizoma Polygonati Odorati 11-19 part, Radix Achyranthis Bidentatae 13-21 part, Herba Andrographis 15-22 part, Herba Selaginellae Moellendorfii 8-13 part, Foliumet Ramulus Evodiae 10-18 part, Herba Kalimeridis 10-17 part, Radix Lamiophlomidis Rotatae 15-20 part, Caulis et Folium fici Tikouae 12-21 part, Cortex Albiziae 8-16 part, Myrrha 13-19 part, Folium Nerviliae fordii 14-20 part, Ramulus viticis negundo 15-20 part, Folium et Fructus Helwingiae 10-18 part, Herba Agrimoniae 16-26 part, Herba Pyrolae 8-17 part, Fructus Elaeagni 11-17 part, Herba Hyperici perforati 18-26 part, Rhizoma Polygoni Cuspidati 10-15 part, Bark of Lindenleaf Torricellia 15-19 part, Radix Ulmi Tonkinesis 15-21 part, Folium Sennae 10-19 part, Fructus Trichosanthis 17-22 part, Fructus Cannabis 7-15 part and Radix Glycyrrhizae 10-19 part.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix seu Caulis Verntilaginis Leiocarpae 11-14 part, Arillus Longan 13-18 part, Radix Glehniae 21-25 part, Herba Cistanches 17-25 part, Rhizoma Curcumae 11-17 part, Fructus Jujubae 16-24 part, Pedicularis rex C. B. Clarke ex Maxim. 13-21 part, Radix Polygoni Multiflori 21-27 part, Fructus Litchi 17-21 part, Rhizoma Polygonati Odorati 12-18 part, Radix Achyranthis Bidentatae 15-20 part, Herba Andrographis 16-20 part, Herba Selaginellae Moellendorfii 9-12 part, Foliumet Ramulus Evodiae 11-16 part, Herba Kalimeridis 11-15 part, Radix Lamiophlomidis Rotatae 17-19 part, Caulis et Folium fici Tikouae 13-20 part, Cortex Albiziae 9-15 part, Myrrha 14-18 part, Folium Nerviliae fordii 15-18 part, Ramulus viticis negundo 16-19 part, Folium et Fructus Helwingiae 11-17 part, Herba Agrimoniae 17-25 part, Herba Pyrolae 9-16 part, Fructus Elaeagni 12-16 part, Herba Hyperici perforati 19-25 part, Rhizoma Polygoni Cuspidati 11-14 part, Bark of Lindenleaf Torricellia 16-18 part, Radix Ulmi Tonkinesis 16-20 part, Folium Sennae 11-18 part, Fructus Trichosanthis 18-20 part, Fructus Cannabis 8-14 part and Radix Glycyrrhizae 11-18 part.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix seu Caulis Verntilaginis Leiocarpae 11 parts, Arillus Longan 18 parts, Radix Glehniae 23 parts, Herba Cistanches 25 parts, Rhizoma Curcumae 11 parts, 24 parts, Fructus Jujubae, Pedicularis rex C. B. Clarke ex Maxim. 18 parts, Radix Polygoni Multiflori 21 parts, Fructus Litchi 19 parts, Rhizoma Polygonati Odorati 17 parts, Radix Achyranthis Bidentatae 15 parts, Herba Andrographis 20 parts, Herba Selaginellae Moellendorfii 10 parts, Foliumet Ramulus Evodiae 15 parts, Herba Kalimeridis 11 parts, Radix Lamiophlomidis Rotatae 17 parts, Caulis et Folium fici Tikouae 20 parts, Cortex Albiziae 9 parts, Myrrha 18 parts, Folium Nerviliae fordii 15 parts, Ramulus viticis negundo 18 parts, Folium et Fructus Helwingiae 16 parts, Herba Agrimoniae 17 parts, Herba Pyrolae 16 parts, Fructus Elaeagni 12 parts, Herba Hyperici perforati 19 parts, Rhizoma Polygoni Cuspidati 14 parts, Bark of Lindenleaf Torricellia 17 parts, Radix Ulmi Tonkinesis 16 parts, Folium Sennae 18 parts, Fructus Trichosanthis 20 parts, Fructus Cannabis 13 parts and 11 parts, Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix seu Caulis Verntilaginis Leiocarpae 12 parts, Arillus Longan 15 parts, Radix Glehniae 21 parts, Herba Cistanches 19 parts, Rhizoma Curcumae 13 parts, 21 parts, Fructus Jujubae, Pedicularis rex C. B. Clarke ex Maxim. 21 parts, Radix Polygoni Multiflori 27 parts, Fructus Litchi 21 parts, Rhizoma Polygonati Odorati 12 parts, Radix Achyranthis Bidentatae 16 parts, Herba Andrographis 17 parts, Herba Selaginellae Moellendorfii 9 parts, Foliumet Ramulus Evodiae 16 parts, Herba Kalimeridis 15 parts, Radix Lamiophlomidis Rotatae 18 parts, Caulis et Folium fici Tikouae 16 parts, Cortex Albiziae 11 parts, Myrrha 14 parts, Folium Nerviliae fordii 18 parts, Ramulus viticis negundo 19 parts, Folium et Fructus Helwingiae 11 parts, Herba Agrimoniae 25 parts, Herba Pyrolae 13 parts, Fructus Elaeagni 14 parts, Herba Hyperici perforati 25 parts, Rhizoma Polygoni Cuspidati 13 parts, Bark of Lindenleaf Torricellia 18 parts, Radix Ulmi Tonkinesis 19 parts, Folium Sennae 15 parts, Fructus Trichosanthis 18 parts, Fructus Cannabis 8 parts and 16 parts, Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix seu Caulis Verntilaginis Leiocarpae 14 parts, Arillus Longan 13 parts, Radix Glehniae 25 parts, Herba Cistanches 17 parts, Rhizoma Curcumae 17 parts, 16 parts, Fructus Jujubae, Pedicularis rex C. B. Clarke ex Maxim. 13 parts, Radix Polygoni Multiflori 23 parts, Fructus Litchi 17 parts, Rhizoma Polygonati Odorati 18 parts, Radix Achyranthis Bidentatae 20 parts, Herba Andrographis 16 parts, Herba Selaginellae Moellendorfii 12 parts, Foliumet Ramulus Evodiae 11 parts, Herba Kalimeridis 13 parts, Radix Lamiophlomidis Rotatae 19 parts, Caulis et Folium fici Tikouae 13 parts, Cortex Albiziae 15 parts, Myrrha 15 parts, Folium Nerviliae fordii 17 parts, Ramulus viticis negundo 16 parts, Folium et Fructus Helwingiae 17 parts, Herba Agrimoniae 19 parts, Herba Pyrolae 9 parts, Fructus Elaeagni 16 parts, Herba Hyperici perforati 23 parts, Rhizoma Polygoni Cuspidati 11 parts, Bark of Lindenleaf Torricellia 16 parts, Radix Ulmi Tonkinesis 20 parts, Folium Sennae 11 parts, Fructus Trichosanthis 19 parts, Fructus Cannabis 14 parts and 18 parts, Radix Glycyrrhizae.

When the dosage form of described medicine is ointment, its preparation method comprises the following steps:

Described raw medicinal material is soaked 1-2 hour in described ratio mixing, is then placed in multi-function extractor, first time decocts 5-10 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 5-10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C, cooling, tinning after ultraviolet radiation sterilizing.

When the dosage form of described medicine is spray, its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, 80-160 order filters, get 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

When the dosage form of described medicine is liniment, its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds coarse powder 8-10 times amount soak by water 1-3 hour, and second time adds coarse powder 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in the glycerol accounting for a and b mixture gross mass 10% after being mixed with fine powder b by fine powder a and make liniment.

When the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

For solving the problems of the technologies described above, the present invention also provide a kind of treat QIXUELIANGXU type burn medicine, pharmaceutical dosage form is: decoction, tablet, film coated tablet, enteric coated tablet, sugar coated tablet, capsule, soft capsule, oral liquid, hard capsule, suck agent, electuary, honey refining pill, granule, powder, sublimed preparation, syrup; External drug dosage forms is liniment, drop, ointment, fumigant, patch, suppository, tincture, plaster, gel and spray.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the present invention has effect of benefiting vital QI and blood, holds concurrently with blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, astringing to arrest bleeding, and nursing for treating QIXUELIANGXU type is burnt; Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of the present invention, can improve animal economy immunity, promotes the dynamic equilibrium such as Water-Electrolyte, targeting is stronger, evident in efficacy, can infection, prevent wound surface from spreading, improve cytothesis, skin healing ability, not easily produce drug resistance, and cost price is cheap, processing technology is simple, convenient drug administration, patient is easy to accept.

Detailed description of the invention

Chinese medicine is thought, because heat-flash acts on human body, pyretic toxicity is invaded, stagnation of QI-blood, and the lighter's skin and flesh rots, and severe one excessive noxious heat, injures cloudy liquid in body, or pyretic toxicity inside fire attack internal organs, so that internal organs are become estranged, imbalance of YIN and YANG.Gas, blood, body fluid, essence etc. are all the base substances forming human body and maintain human life activity, the raw essence of water and grain of tasteization is all relied constantly to supplement, under the functional activity of internal organs and the dominant force of god, interpenetrate again between them, mutually promote, mutually transform.In physiological function, there is again mutual dependence for existence, mutually to restrict and the substantial connection of refinforcing each other.

Therefore, the present invention take benefiting vital QI and blood as primary treatment principle, hold concurrently with blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, astringing to arrest bleeding, nursing for treating QIXUELIANGXU type is burnt, therefore select following raw medicinal material: Radix seu Caulis Verntilaginis Leiocarpae, Arillus Longan, Radix Glehniae, Herba Cistanches, Rhizoma Curcumae, Fructus Jujubae, Pedicularis rex C. B. Clarke ex Maxim., Radix Polygoni Multiflori, Fructus Litchi, Rhizoma Polygonati Odorati, Radix Achyranthis Bidentatae, Herba Andrographis, Herba Selaginellae Moellendorfii, Foliumet Ramulus Evodiae, Herba Kalimeridis, Radix Lamiophlomidis Rotatae, Caulis et Folium fici Tikouae, Cortex Albiziae, Myrrha, Folium Nerviliae fordii, Ramulus viticis negundo, Folium et Fructus Helwingiae, Herba Agrimoniae, Herba Pyrolae, Fructus Elaeagni, Herba Hyperici perforati, Rhizoma Polygoni Cuspidati, Bark of Lindenleaf Torricellia, Radix Ulmi Tonkinesis, Folium Sennae, Fructus Trichosanthis, Fructus Cannabis and Radix Glycyrrhizae.

Wherein, Radix seu Caulis Verntilaginis Leiocarpae, Arillus Longan, Radix Glehniae, Herba Cistanches, Rhizoma Curcumae, Fructus Jujubae, Pedicularis rex C. B. Clarke ex Maxim., Radix Polygoni Multiflori, Fructus Litchi, Rhizoma Polygonati Odorati, Radix Achyranthis Bidentatae benefiting vital QI and blood; Herba Andrographis, Herba Selaginellae Moellendorfii, Foliumet Ramulus Evodiae, Herba Kalimeridis heat-clearing and toxic substances removing; Radix Lamiophlomidis Rotatae, Caulis et Folium fici Tikouae, Cortex Albiziae, Myrrha, Folium Nerviliae fordii, Ramulus viticis negundo, Folium et Fructus Helwingiae reducing swelling and alleviating pain; Herba Agrimoniae, Herba Pyrolae, Fructus Elaeagni, Herba Hyperici perforati, Rhizoma Polygoni Cuspidati, Bark of Lindenleaf Torricellia, Radix Ulmi Tonkinesis astringing to arrest bleeding; Folium Sennae, Fructus Trichosanthis, Fructus Cannabis relieving constipation by purgation; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Make a general survey of full side, compatibility scientific and precise, the nursing for treating that gathers altogether burns QIXUELIANGXU type burn.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Radix seu Caulis Verntilaginis Leiocarpae: sweet; Temperature.Return lung; Spleen channel.Fill blood; Bone and muscle strengthening; Relax meridians.Main deficient qi and blood; Have through uncomfortable; Blood deficiency amenorrhea; Rheumatalgia; Traumatic injury; Lumbar muscle strain.

Arillus Longan: sweet; Temperature.GUIXIN; Kidney; Liver; Spleen channel.Reinforcing the heart spleen; Replenishing QI and blood; Tranquilizing mind.Main deficiency of both the heart and spleen; Palpitation with fear caused by insufficiency of vital energy and blood; Palpitation with a distress feeling; Insomnia; Forgetful; Blood deficiency and yellow complexion; Have through uncomfortable; Metrorrhagia.

Radix Glehniae: bitter in the mouth; Sweet; Warm in nature.Benefiting vital QI and blood.Main physical weakness; Dizzy; Myasthenia of limbs.

Herba Cistanches: sweet, salty, temperature.Return kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.

Rhizoma Curcumae: acrid in the mouth; Bitter; Warm in nature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis; Removing food stagnancy pain relieving.Main vim and vigour are pained; Eating accumulation; Abdominal distention; Amenorrhea due to stagnation of blood; Dysmenorrhea; Lump in the abdomen tumor mass in the abdomen; Traumatic injury.

Fructus Jujubae: sweet, temperature.Invigorating the spleen and replenishing QI, tranquilizing by nourishing the heart.For diarrhea due to hypofunction of the spleen, cardiopalmus, insomnia, night sweat, thrombocytopenic purpura.

Pedicularis rex C. B. Clarke ex Maxim.: taste is micro-sweet; Cool in nature.Return liver; Spleen channel.Invigorating qi and benefiting blood; Invigorating spleen to remove dampness.Main deficiency of YIN hectic fever; Puerperal hypogalactia; Chronic hepatitis; Cirrhotic ascites; Infantile malnutrition.

Radix Polygoni Multiflori: bitter; Sweet; Puckery; Slightly warm in nature.Return liver; Kidney channel.Nourishing the blood and yin; Loosening bowel to relieve constipation; Preventing the attack (or recurrence) of malaria; Dispel the wind; Removing toxic substances.Main blood deficiency Light-headedness; Cardiopalmus; Insomnia; The soreness of the waist and knees of the hepatic and renal YIN deficiency; Early whitening of beard and hair; Tinnitus; Seminal emission; Dryness of the intestine constipation; Chronic malaria body is empty; Rubella pruritus; Carbuncle sore; Scrofula; Hemorrhoid.

Fructus Litchi: sweet; Acid; Temperature.Return spleen; Liver Channel.To nourish blood spleen invigorating; Promoting the circulation of QI for relieving swelling.Main body is after being ill empty, and Tianjin wound is thirsty; Diarrhea due to hypofunction of the spleen; Singultus; Lack of appetite; Scrofula; Furuncle swells; Traumatic hemorrhage.

Rhizoma Polygonati Odorati: sweet in the mouth, property is put down; Attach to the lung and stomach meridians." property of medicine opinion ": " disease cold and heat time main, interior tonifying for the deficiency, removes asthenia exopathogenic heat, and headache is uneasy, adds and good with it." " Japan hanako materia medica ": " except unhappy, quench the thirst, profit cardiopulmonary, mend five kinds of strain and seven kinds of impairment, deficient, waist foot pain, it is capable fanatical." Compendium of Material Medica: " main air temperature spontaneous perspiration is scorching hot, and malaria with general debility cold and heat, taste void is weary, man's frequent micturition, and consumption of essence, all are deficient.”

Radix Achyranthis Bidentatae: bitter; Acid; Property is put down.Return liver; Kidney channel.Invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow; Draw enemy state's (fire) descending; Inducing diuresis for treating stranguria syndrome.Main soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; Levy abdominal mass; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; Carbuncle malignant boil; Laryngopharynx swelling and pain.

Herba Andrographis: bitter in the mouth; Cold in nature.GUIXIN; Lung; Large intestine; Urinary bladder channel.Heat-clearing and toxic substances removing; Pathogenic fire purging; Dampness.Main anemopyretic cold; Epidemic febrile disease is generated heat; Cough due to lung-heat; Pertussis; Lung abscess; Laryngopharynx swelling and pain; Jaundice due to damp-heat; Stranguria; Erysipelas; Skin infection carbuncle; Eczema; Venom.

Herba Selaginellae Moellendorfii: pungent, micro-sweet is flat.Clearing away heat-damp and promoting diuresis, hemostasis.For acute icterohepatitis, anasarca, hemoptysis of pulmonary tuberculosis, spits blood, bleeding hemorrhoids; Traumatic hemorrhage is controlled in external, burn and scald.

Foliumet Ramulus Evodiae: bitter, cold.Heat-clearing and toxic substances removing, eliminating stasis to stop pain.Prevent and treat influenza, epidemic cerebrospinal meningitis, encephalitis B, heatstroke, cure cold high heat, tonsillitis, pharyngolaryngitis, lung abscess, pneumonia, malaria, rheumatic arthritis, sciatica, lumbago and skelalgia, stomachache, icterohepatitis, Gelsemium elegans Benth. (Herba Gelsemii Elegantis) is poisoning.Osteopatia sprain is controlled in external, worm venom, carbuncle furuncle and phyma poison, trauma infection contamination, eczema, dermatitis.

Herba Kalimeridis: acrid in the mouth; Cool in nature.Return lung; Liver; Stomach; Large intestine channel.Cooling blood for hemostasis; Clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main haematemesis; Epistaxis; Dysentery; Metrorrhagia; Wound hemorrhage; Jaundice; Edema; Stranguria with turbid discharge; Flu; Cough; Pharyngalgia sore throat; Hemorrhoid; Carbuncle; Erysipelas; Infantile malnutrition.

Herba Rorippae: acrid in the mouth; Bitter; Slightly warm in nature.Return lung; Liver Channel.Expelling phlegm for arresting cough; Induce sweat cold expelling; Promoting blood circulation and detoxication; Dampness removing jaundice eliminating.Main cough phlegm dyspnea; Cold, fever; Measles is sent out not smooth thoroughly; Rheumatic arthralgia; Laryngopharynx swelling and pain; Furuncle carbuncle; Dermatitis rhus; Amenorrhea; Traumatic injury; Jaundice; Edema.

Radix Lamiophlomidis Rotatae: sweet in the mouth; Bitter; Property is put down.Blood circulation promoting and blood stasis dispelling; Reducing swelling and alleviating pain.Main traumatic injury; Bones and muscles pain; Arthralgia; Dysmenorrhea; Metrorrhagia.

Caulis et Folium fici Tikouae: bitter in the mouth; Cold in nature.Clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat; Dysentery; Edema; Yellow cellulitis; Infantile dyspepsia; Rheumatalgia; Amenorrhea; Leukorrhagia; Traumatic injury; Bleeding hemorrhoids; Innominate toxic swelling.

Cortex Albiziae: sweet; Flat.GUIXIN; Liver Channel.To calm the nerves resolving depression, eliminating carbuncle of invigorating blood circulation.Main irritability; Melancholy, sleeplessness, inside and outside carbuncle and ulcer, traumatic injury.1. " herbal classic ": main settling five organs, and will, make us happy carefree.2. " Japan hanako materia medica ": soft extracts, subduing inflammation reuniting the fractured tendons and bones.3. " detailed outline ": and blood, detumescence, pain relieving.

Myrrha: bitter; Flat.Return liver; Spleen; The heart; Kidney channel.Promoting blood circulation and stopping pain; Detumescence and promoting granulation.Main breast abdomen stasis of blood pain; Dysmenorrhea; Amenorrhea; Lump in the abdomen; Traumatic injury; Carbuncle skin infection; Intestinal carbuncle; Conjunctival congestion and swelling pain.

Folium Nerviliae fordii: sweet; Cool; Nourishing the lung to arrest cough; Heat-clearing and toxic substances removing; Eliminating stasis to stop pain.Main pulmonary tuberculosis spitting of blood; Cough due to lung-heat; Stomatitis; Laryngopharynx swelling and pain; Scrofula; Sore swollen toxin; Traumatic injury.1. " south of the Five Ridges gather medicinal herbs record ": control scrofula, and meat decoct soup clothes or stir-fry and eat; Reason phlegm-fire hemoptysis, quench skin ulcer, is decocted in water for oral dose; Infusing drugs in wine controls internal injury.2. " Luchuan book on Chinese herbal medicine ": hemostasis, blood stasis removing, controls traumatic injury.3. " Nanning City's medicine will ": nourishing the lung to arrest cough, antipyreticly to clear away heart-fire.Control pulmonary tuberculosis, and separate carbon monoxide poisoning.4. " Guangxi Chinese medicinal herbal ": mash outer painting, can sore be separated.5. " choosing of Simao, Yunnan Chinese herbal medicine ": dissipating blood stasis for subsidence of swelling, sedation-analgesia.Control psychosis, traumatic injury, the swollen stasis of blood pain of knot.

Ramulus viticis negundo: acrid in the mouth; Micro-hardship; Property is put down.GUIXIN; Lung; Liver Channel.Expelling pathogenic wind from the body surface; Reducing swelling and alleviating pain.Main cold, fever, cough; Sore throat swells and ache; Rheumatic ostalgia; Toothache; Scald.

Folium et Fructus Helwingiae: bitter in the mouth; Pungent; Property is put down.Expelling wind and removing dampness; Promoting blood circulation and detoxication.Main cold cough; Rheumatic arthralgia; Stomachache; Letter disease; Have blood in stool; Menstruation Wang adjusts; Traumatic injury congestive edema; Fracture; Carbuncle furuncle poison; Venom." Shaanxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control burn, furuncle carbuncle, innominate toxic swelling, knife injury, venom, stomachache.

Herba Agrimoniae: bitter in the mouth, puckery, property is put down.Return lung; Liver; Spleen channel.Astringing to arrest bleeding, dysentery relieving, parasite killing.Main spitting of blood; Spit blood; Hematuria; Have blood in stool; Dysentery; Bleeding not during menses; Impairment caused by overstrain takes off power; Carbuncle; Traumatic injury; Wound hemorrhage.

Herba Pyrolae: sweet; Bitter; Warm in nature.Return liver; Kidney channel.The kidney invigorating bone strengthening; Expelling wind and removing dampness; Cough-relieving; Hemostasis.Main lumbago due to renal deficiency; Rheumatic arthralgia; Muscles and bones flaccidity is soft; New chronic cough is coughed; Spit blood; Epistaxis; Metrorrhagia; Traumatic hemorrhage.

Fructus Elaeagni: acid; Puckery; Flat.Return lung; Stomach; Large intestine channel.Astringing to arrest diarrhea; Strengthening the spleen to promote digestion; Relieving cough and asthma; Hemostasis.Master has loose bowels; Dysentery; Inappetence; Dyspepsia; Cough and asthma; Metrorrhagia; Hemorrhoid hematochezia.

Herba Hyperici perforati: bitter in the mouth; Puckery; Property is put down; Return Liver Channel.Astringing to arrest bleeding; Regulating menstruation lactogenesis; Heat-clearing and toxic substances removing; Dampness removing.Main spitting of blood; Spit blood; Discharging fresh blood stool; Metrorrhagia; Traumatic hemorrhage; Menstruation is fried and is adjusted; Breast woman agalactia; Jaundice; Have sore throat; Conjunctival congestion and swelling pain; Urinary tract infection; The raw skin ulcer of mouth and nose; Carbuncle furuncle and phyma poison; Burn and scald.

Rhizoma Polygoni Cuspidati: bitter; Acid; Cold nature.Return liver; Gallbladder meridian.Promoting blood circulation to remove blood stasis; Dispelling wind and removing obstruction in the collateral; Clearing away heat-damp and promoting diuresis; Removing toxic substances.Housewife female's amenorrhea; Dysmenorrhea; Lochiostasis; Lump in the abdomen; Injury from falling down; Rheumatic arthralgia; Jaundice due to damp-heat; Stranguria with turbid discharge leukorrhagia; Sore swollen toxin; Venom; Burn due to hot liquid or fire.1. " south of the Five Ridges gather medicinal herbs record ": treating snakebite, impetigo, stops loss the pain of injury.2. " Guizhou side's medicine among the people collection ": astringing to arrest bleeding, control hemorrhoid complicated by anal fistula, curing rheumatism, deliver cold expelling, dissipating blood stasis blood, burn is controlled in external.3. " experiment of TCM research ": control excess-fire toothache, the rotten lower limb of eczema, toe discrimination wets rotten.

Bark of Lindenleaf Torricellia: bitter; Puckery; Cool.Astringing to arrest bleeding; Reunion of fractured tendons and bones.Main traumatic hemorrhage; Fracture; Burn and scald; Chronic gastritis; Gastric ulcer.

Radix Ulmi Tonkinesis: puckery; Property is put down.Astringing to arrest bleeding; Synthetism is subsided a swelling.Main haematemesis; Have blood in stool; Hematuria; Traumatic hemorrhage; Fracture.

Folium Sennae: sweetness and bitterness; Cold and cool.Return large intestine channel.Purging heat to relax the bowels, consumer product dredge stasis, hemostasis.Main constipation with heat retention, habitual constipation, stagnant abdominal distention, edema tympanites, taste-blindness rate is hemorrhage.

Fructus Trichosanthis: sweet in the mouth; Micro-hardship; Cold in nature.Return lung; Stomach; Large intestine channel.Removing heat-phlegm; Wide born of the same parents' eliminating stagnation; Moisturize laxation.Main cough due to lung-heat; The thoracic obstruction; Quench one's thirst; Constipation; Carbuncle sore tumefacting virus.

Fructus Cannabis: sweet; Property is put down.Return spleen; Stomach; Large intestine channel.Moisturize laxation; Relieving stranguria by diuresis; Invigorate blood circulation.Main dryness of the intestine constipation; Migratory arthralgia; Quench one's thirst; Edema due to wind pathogen; Pyretic stranguria; Dysentery; Menoxenia; Skin ulcer tinea; Erysipelas.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 ointment of the present invention

Get Radix seu Caulis Verntilaginis Leiocarpae 11g, Arillus Longan 18g, Radix Glehniae 23g, Herba Cistanches 25g, Rhizoma Curcumae 11g, Fructus Jujubae 24g, Pedicularis rex C. B. Clarke ex Maxim. 18g, Radix Polygoni Multiflori 21g, Fructus Litchi 19g, Rhizoma Polygonati Odorati 17g, Radix Achyranthis Bidentatae 15g, Herba Andrographis 20g, Herba Selaginellae Moellendorfii 10g, Foliumet Ramulus Evodiae 15g, Herba Kalimeridis 11g, Radix Lamiophlomidis Rotatae 17g, Caulis et Folium fici Tikouae 20g, Cortex Albiziae 9g, Myrrha 18g, Folium Nerviliae fordii 15g, Ramulus viticis negundo 18g, Folium et Fructus Helwingiae 16g, Herba Agrimoniae 17g, Herba Pyrolae 16g, Fructus Elaeagni 12g, Herba Hyperici perforati 19g, Rhizoma Polygoni Cuspidati 14g, Bark of Lindenleaf Torricellia 17g, Radix Ulmi Tonkinesis 16g, Folium Sennae 18g, Fructus Trichosanthis 20g, Fructus Cannabis 13g and Radix Glycyrrhizae 11g.

Its preparation method comprises the following steps:

By described raw medicinal material in described ratio mixing immersion 2 hours, be then placed in multi-function extractor, first time decocts 6 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 9 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.08MPa, temperature remains on 70 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C, cooling, tinning after ultraviolet radiation sterilizing.

Embodiment 2 spray of the present invention

Get Radix seu Caulis Verntilaginis Leiocarpae 12g, Arillus Longan 15g, Radix Glehniae 21g, Herba Cistanches 19g, Rhizoma Curcumae 13g, Fructus Jujubae 21g, Pedicularis rex C. B. Clarke ex Maxim. 21g, Radix Polygoni Multiflori 27g, Fructus Litchi 21g, Rhizoma Polygonati Odorati 12g, Radix Achyranthis Bidentatae 16g, Herba Andrographis 17g, Herba Selaginellae Moellendorfii 9g, Foliumet Ramulus Evodiae 16g, Herba Kalimeridis 15g, Radix Lamiophlomidis Rotatae 18g, Caulis et Folium fici Tikouae 16g, Cortex Albiziae 11g, Myrrha 14g, Folium Nerviliae fordii 18g, Ramulus viticis negundo 19g, Folium et Fructus Helwingiae 11g, Herba Agrimoniae 25g, Herba Pyrolae 13g, Fructus Elaeagni 14g, Herba Hyperici perforati 25g, Rhizoma Polygoni Cuspidati 13g, Bark of Lindenleaf Torricellia 18g, Radix Ulmi Tonkinesis 19g, Folium Sennae 15g, Fructus Trichosanthis 18g, Fructus Cannabis 8g and Radix Glycyrrhizae 16g.

Its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add the water soaking 6 hours relative to the mixture quality 4 times obtained, after intense fire boils, using slow fire instead, to decoct the 50 minutes dosage to medicinal liquid be slowly 300ml, decocts 3 times, merges decoction liquor and filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 90% soak with ethanol 1 hour, extract twice, each 2 hours, merge extractive liquid, 160 orders filter, get 10000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

Embodiment 3 liniment of the present invention

Get Radix seu Caulis Verntilaginis Leiocarpae 14g, Arillus Longan 13g, Radix Glehniae 25g, Herba Cistanches 17g, Rhizoma Curcumae 17g, Fructus Jujubae 16g, Pedicularis rex C. B. Clarke ex Maxim. 13g, Radix Polygoni Multiflori 23g, Fructus Litchi 17g, Rhizoma Polygonati Odorati 18g, Radix Achyranthis Bidentatae 20g, Herba Andrographis 16g, Herba Selaginellae Moellendorfii 12g, Foliumet Ramulus Evodiae 11g, Herba Kalimeridis 13g, Radix Lamiophlomidis Rotatae 19g, Caulis et Folium fici Tikouae 13g, Cortex Albiziae 15g, Myrrha 15g, Folium Nerviliae fordii 17g, Ramulus viticis negundo 16g, Folium et Fructus Helwingiae 17g, Herba Agrimoniae 19g, Herba Pyrolae 9g, Fructus Elaeagni 16g, Herba Hyperici perforati 23g, Rhizoma Polygoni Cuspidati 11g, Bark of Lindenleaf Torricellia 16g, Radix Ulmi Tonkinesis 20g, Folium Sennae 11g, Fructus Trichosanthis 19g, Fructus Cannabis 14g and Radix Glycyrrhizae 18g.

Its preparation method comprises the following steps:

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds coarse powder 8 times amount soak by water 2 hours, and second time adds coarse powder 6 times amount soak by water 1 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Embodiment 4 granule of the present invention

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.09Mpa, relative density is the mastic of 1.10, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.4 times and 0.2 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Hypersensitive test:

Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration; The test group ointment of the embodiment of the present invention 1.The ointment 0.1g getting the embodiment of the present invention 1 is applied to unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, at back, the same area smeared this product 0.1g, at once observes after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

Hypersensitive test:

Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration; The test group spray of the embodiment of the present invention 2.Get the spray of the embodiment of the present invention 2 in unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, spray this product 1 time at back the same area, at once observe after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

Acute skin irritation test:

These product are according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, the liniment prepared by embodiments of the invention 3 to be directly coated on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.

Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 4 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore the granule acute toxicity of the embodiment of the present invention 4 is low, clinical drug safety.

Clinical data:

Case selection: choose standard compliant patient 344 example, based on clinic case, partial hospitalization case; Be blister burn.2-68 years old ages, 42 years old mean age; Man 255 example; Female 89 example; Wherein, flame burn (firewood, electric spark, fireworks and firecrackers etc.) 99 example, hot liquid scald (boiled water, hot medicated porridge, the oil that boils, containing alkalescence paper pulp etc.) 245 example; Area minimum 32%, maximum 54%; Based on extremity trunk, throughout head, face, extremity, trunk; Low grade fever or do not generate heat, spiritlessness and weakness, inappetence, emaciated physique, lustreless complexion, wound granulation color is light, is difficult to healing; Light red tongue, white and thin fur, thready and weak pulse, dialectically belongs to QIXUELIANGXU type.The vesicle do not waited sized by the performance of wound surface situation, takes on a red color bottom vesicle or white, is filled with limpid, sticky liquid.Touch a tender spot responsive, bleach during compressing.

344 routine patients are divided into four groups at random, and four groups, at age, sex and course of disease no significant difference (P > 0.05), have comparability:

Ointment+Granules in Treating group: 86 people, male 64 people, female 22 people.

Spray+Granules in Treating group: 86 people, male 63 people, female 23 people.

Liniment+Granules in Treating group: 86 people, male 64 people, female 22 people.

JINGWANHONG ointment for scald matched group: 86 people, male 64 people, female 22 people.

Diagnostic criteria:

Burn degree: the degree of depth adopting three degree of international quarterings to judge burn more:

I °: pathological changes is the lightest.Generally injure horny layer of epidermis, clear layer, granular layer, regeneration capacity is strong.Scorch degree of depth erythema shape, pain, hyperesthesia.The normal recovery from illness of (3-5 days) desquamation in a short time, does not leave over cicatrix.Sometimes pigmentation is had.

Light Ⅱ°: injure the stratum germinativum of epidermis, papillary layer of corium.The regeneration of epithelium depends on remaining stratum germinativum and the adnexa of skin.Local is obviously red and swollen, and vesicle is comparatively large, and after removing epidermal area, wound surface is moistening, wound end bright red, and has red granules or venation shape vasoganglion.As without infecting, generally healing after one or two week, also not staying cicatrix.Sometimes the pigment alteration of long period is had.

DepthⅡ°: the skin corium injuring below dermal papilla layer, but still remain some dermis.Long-pending thin liquid under epidermis, or vesicle is less, and after removing epidermis, wound surface is micro-wet or red and white, and visible many dots in red or minute blood vessel sometimes, edema is obvious.Insensitive.More leave over cicatrix after, the chance that scar tissue hypertrophy occurs is also more more.As nothing infects, healing time generally needs three surroundings.As infected, not only healing time extends, and the appendages of skin or epithelium island can be destroyed time serious, wound surface must can heal in skin-grafting.

III °: full thickness bums even reaches subcutaneous, muscle or skeleton.Wound surface analgesis, in eschar shape, the blood vessel of visible dendroid thromboembolism under crust.Pain disappears.Because skin and adnexa thereof are all ruined, wound surface is without the source of epithelium regeneration, and reparation must depend on skin-grafting and skin flap transplantation reparation, and severe patient needs row amputation.

Therapeutic Method:

First cold water external application all first adopted for fire victim or use tap water wound surface, to reduce heating power to the damage of integumentary musculature as far as possible; Around simple removing wound surface and wound surface after foreign body, rinse with 0.9% sodium chloride solution, then with 1 ‰ bromogeramine solutions sterilizations, sterile gauze wipes dry wound surface water liquid, and the bleb skin of pollution is stripped off in cleaning, large vesicle gives tapping and subtracts and open.

Ointment+Granules in Treating group: directly smear affected part with the wound surface of ointment to women's head-ornaments, perineal position prepared by the embodiment of the present invention 1, every 4 h once, and clear up secretions around, in time to the wound surface of trunk, extremity, multilamellar is all adopted to scribble the gauze external application of ointment, aseptic dressing is wrapped up, and the next day changes dressings once, until wound healing, for the wound surface polluted, scribble ointment yarn external application wrapping with monolayer after debridement, change dressings every day once, every day 2 times; It within every 14 days, is 1 course for the treatment of; The granule of the oral embodiment of the present invention 4 simultaneously, every day 3 times, one time 1 bag.

Spray+Granules in Treating group: the spray spraying affected part of preparing by the embodiment of the present invention 2, to the wound surface direct spraying affected part of women's head-ornaments, perineal position, every 4 h are once, and the secretions around cleaning in time, to the wound surface of trunk, extremity, all adopt multilamellar to be sprayed with the gauze external application of spray, aseptic dressing is wrapped up, the next day, changes dressings once, until wound healing, for the wound surface polluted, after debridement, be sprayed with spray yarn external application wrapping with monolayer, change dressings every day once, every day 2 times; It within every 14 days, is 1 course for the treatment of; The granule of the oral embodiment of the present invention 4 simultaneously, every day 3 times, one time 1 bag.

Liniment+Granules in Treating group: smear affected part with liniment prepared by the embodiment of the present invention 3, be directly coated with affected part to the wound surface of women's head-ornaments, perineal position, every 4 h once, and the secretions around cleaning in time, to the wound surface of trunk, extremity, all adopt multilamellar to scribble the gauze external application of liniment, aseptic dressing is wrapped up, the next day, changes dressings once, until wound healing, for the wound surface polluted, after debridement, scribble liniment yarn external application wrapping with monolayer, change dressings every day once, every day 2 times; It within every 14 days, is 1 course for the treatment of; The granule of the oral embodiment of the present invention 4 simultaneously, every day 3 times, one time 1 bag.

JINGWANHONG ointment for scald matched group: be coated with JINGWANHONG ointment for scald to the wound surface of women's head-ornaments, perineal position is directly outer, every 4 h once, and clear up secretions around, in time to the wound surface of trunk, extremity, multilamellar is all adopted to scribble the gauze external application of JINGWANHONG ointment for scald, aseptic dressing is wrapped up, and the next day changes dressings once, until wound healing, for the wound surface polluted, scribble JINGWANHONG ointment for scald yarn external application wrapping with monolayer after debridement, changing dressings every day once, 14 days is a course for the treatment of.

Criterion of therapeutical effect:

Be diagnosis basis according to international and China's general it " three degree of quarterings ".

Cure: after the treatment, infect various deep burn and the patient of different area, in 1 course for the treatment of, skin ulcer face occurs that first phase physiological heals, and does not stay dysfunction, cicatrix, contracture, vitreous degeneration etc.;

Effective: after the treatment, in 10 ~ 60min, pain is alleviated, and swelling fades, or in 1 week, skin ulcer face occurs that physiological reverse is effective;

Invalid: after the treatment, do not occur in 1 course for the treatment of that physiological reverses as invalid.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy QIXUELIANGXU type of the present invention to burn, relative to matched group on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy QIXUELIANGXU type of the present invention to burn, relative to matched group, treatment time significantly shortens.

After table 1 Four composition does not treat two courses for the treatment of, Clinical efficacy comparison is routine

The wound healing time that four groups, table 2 is cured and the average healing compare

According to the clinical statistics in above table, medicine provided by the invention has determined curative effect, rapid-action, effective percentage is high, safety is high, the advantage that has no side effect.

Model case:

Ma, female, 32 years old.Patient is certain market office worker, in August, 2012 because of market breaking out of fire burn, poor effect after other hospitalizes, patient's spiritlessness and weakness when proceeding to my institute, lustreless complexion, light red tongue, white and thin fur, thready and weak pulse, wound granulation color is light; Be deepⅱ°burn after diagnosing, burn surface area is 37%, Chinese medical discrimination QIXUELIANGXU type.Take the capsule of the embodiment of the present invention 4, after debridement, with the ointment gauze external application wrapping scribbling the embodiment of the present invention 1, change dressings every day 1 time, patient's spirit amelioration after 1 week, most of wound healing in 15 days, 25d patient's recovery from illness of being in hospital is left hospital.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. the medicine for nursing for treating QIXUELIANGXU type burn, it is characterized in that, described medicine comprises following raw medicinal material: Radix seu Caulis Verntilaginis Leiocarpae, Arillus Longan, Radix Glehniae, Herba Cistanches, Rhizoma Curcumae, Fructus Jujubae, Pedicularis rex C. B. Clarke ex Maxim., Radix Polygoni Multiflori, Fructus Litchi, Rhizoma Polygonati Odorati, Radix Achyranthis Bidentatae, Herba Andrographis, Herba Selaginellae Moellendorfii, Foliumet Ramulus Evodiae, Herba Kalimeridis, Radix Lamiophlomidis Rotatae, Caulis et Folium fici Tikouae, Cortex Albiziae, Myrrha, Folium Nerviliae fordii, Ramulus viticis negundo, Folium et Fructus Helwingiae, Herba Agrimoniae, Herba Pyrolae, Fructus Elaeagni, Herba Hyperici perforati, Rhizoma Polygoni Cuspidati, Bark of Lindenleaf Torricellia, Radix Ulmi Tonkinesis, Folium Sennae, Fructus Trichosanthis, Fructus Cannabis and Radix Glycyrrhizae.

2. medicine according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix seu Caulis Verntilaginis Leiocarpae 10-15 part, Arillus Longan 12-19 part, Radix Glehniae 20-26 part, Herba Cistanches 16-27 part, Rhizoma Curcumae 10-18 part, Fructus Jujubae 15-25 part, Pedicularis rex C. B. Clarke ex Maxim. 12-22 part, Radix Polygoni Multiflori 20-28 part, Fructus Litchi 16-23 part, Rhizoma Polygonati Odorati 11-19 part, Radix Achyranthis Bidentatae 13-21 part, Herba Andrographis 15-22 part, Herba Selaginellae Moellendorfii 8-13 part, Foliumet Ramulus Evodiae 10-18 part, Herba Kalimeridis 10-17 part, Radix Lamiophlomidis Rotatae 15-20 part, Caulis et Folium fici Tikouae 12-21 part, Cortex Albiziae 8-16 part, Myrrha 13-19 part, Folium Nerviliae fordii 14-20 part, Ramulus viticis negundo 15-20 part, Folium et Fructus Helwingiae 10-18 part, Herba Agrimoniae 16-26 part, Herba Pyrolae 8-17 part, Fructus Elaeagni 11-17 part, Herba Hyperici perforati 18-26 part, Rhizoma Polygoni Cuspidati 10-15 part, Bark of Lindenleaf Torricellia 15-19 part, Radix Ulmi Tonkinesis 15-21 part, Folium Sennae 10-19 part, Fructus Trichosanthis 17-22 part, Fructus Cannabis 7-15 part and Radix Glycyrrhizae 10-19 part.

3. medicine according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix seu Caulis Verntilaginis Leiocarpae 11-14 part, Arillus Longan 13-18 part, Radix Glehniae 21-25 part, Herba Cistanches 17-25 part, Rhizoma Curcumae 11-17 part, Fructus Jujubae 16-24 part, Pedicularis rex C. B. Clarke ex Maxim. 13-21 part, Radix Polygoni Multiflori 21-27 part, Fructus Litchi 17-21 part, Rhizoma Polygonati Odorati 12-18 part, Radix Achyranthis Bidentatae 15-20 part, Herba Andrographis 16-20 part, Herba Selaginellae Moellendorfii 9-12 part, Foliumet Ramulus Evodiae 11-16 part, Herba Kalimeridis 11-15 part, Radix Lamiophlomidis Rotatae 17-19 part, Caulis et Folium fici Tikouae 13-20 part, Cortex Albiziae 9-15 part, Myrrha 14-18 part, Folium Nerviliae fordii 15-18 part, Ramulus viticis negundo 16-19 part, Folium et Fructus Helwingiae 11-17 part, Herba Agrimoniae 17-25 part, Herba Pyrolae 9-16 part, Fructus Elaeagni 12-16 part, Herba Hyperici perforati 19-25 part, Rhizoma Polygoni Cuspidati 11-14 part, Bark of Lindenleaf Torricellia 16-18 part, Radix Ulmi Tonkinesis 16-20 part, Folium Sennae 11-18 part, Fructus Trichosanthis 18-20 part, Fructus Cannabis 8-14 part and Radix Glycyrrhizae 11-18 part.

4. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix seu Caulis Verntilaginis Leiocarpae 11 parts, Arillus Longan 18 parts, Radix Glehniae 23 parts, Herba Cistanches 25 parts, Rhizoma Curcumae 11 parts, 24 parts, Fructus Jujubae, Pedicularis rex C. B. Clarke ex Maxim. 18 parts, Radix Polygoni Multiflori 21 parts, Fructus Litchi 19 parts, Rhizoma Polygonati Odorati 17 parts, Radix Achyranthis Bidentatae 15 parts, Herba Andrographis 20 parts, Herba Selaginellae Moellendorfii 10 parts, Foliumet Ramulus Evodiae 15 parts, Herba Kalimeridis 11 parts, Radix Lamiophlomidis Rotatae 17 parts, Caulis et Folium fici Tikouae 20 parts, Cortex Albiziae 9 parts, Myrrha 18 parts, Folium Nerviliae fordii 15 parts, Ramulus viticis negundo 18 parts, Folium et Fructus Helwingiae 16 parts, Herba Agrimoniae 17 parts, Herba Pyrolae 16 parts, Fructus Elaeagni 12 parts, Herba Hyperici perforati 19 parts, Rhizoma Polygoni Cuspidati 14 parts, Bark of Lindenleaf Torricellia 17 parts, Radix Ulmi Tonkinesis 16 parts, Folium Sennae 18 parts, Fructus Trichosanthis 20 parts, Fructus Cannabis 13 parts and 11 parts, Radix Glycyrrhizae.

5. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix seu Caulis Verntilaginis Leiocarpae 12 parts, Arillus Longan 15 parts, Radix Glehniae 21 parts, Herba Cistanches 19 parts, Rhizoma Curcumae 13 parts, 21 parts, Fructus Jujubae, Pedicularis rex C. B. Clarke ex Maxim. 21 parts, Radix Polygoni Multiflori 27 parts, Fructus Litchi 21 parts, Rhizoma Polygonati Odorati 12 parts, Radix Achyranthis Bidentatae 16 parts, Herba Andrographis 17 parts, Herba Selaginellae Moellendorfii 9 parts, Foliumet Ramulus Evodiae 16 parts, Herba Kalimeridis 15 parts, Radix Lamiophlomidis Rotatae 18 parts, Caulis et Folium fici Tikouae 16 parts, Cortex Albiziae 11 parts, Myrrha 14 parts, Folium Nerviliae fordii 18 parts, Ramulus viticis negundo 19 parts, Folium et Fructus Helwingiae 11 parts, Herba Agrimoniae 25 parts, Herba Pyrolae 13 parts, Fructus Elaeagni 14 parts, Herba Hyperici perforati 25 parts, Rhizoma Polygoni Cuspidati 13 parts, Bark of Lindenleaf Torricellia 18 parts, Radix Ulmi Tonkinesis 19 parts, Folium Sennae 15 parts, Fructus Trichosanthis 18 parts, Fructus Cannabis 8 parts and 16 parts, Radix Glycyrrhizae.

6. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described endo-medicine, the ratio of weight and number of each raw medicinal material is: Radix seu Caulis Verntilaginis Leiocarpae 14 parts, Arillus Longan 13 parts, Radix Glehniae 25 parts, Herba Cistanches 17 parts, Rhizoma Curcumae 17 parts, 16 parts, Fructus Jujubae, Pedicularis rex C. B. Clarke ex Maxim. 13 parts, Radix Polygoni Multiflori 23 parts, Fructus Litchi 17 parts, Rhizoma Polygonati Odorati 18 parts, Radix Achyranthis Bidentatae 20 parts, Herba Andrographis 16 parts, Herba Selaginellae Moellendorfii 12 parts, Foliumet Ramulus Evodiae 11 parts, Herba Kalimeridis 13 parts, Radix Lamiophlomidis Rotatae 19 parts, Caulis et Folium fici Tikouae 13 parts, Cortex Albiziae 15 parts, Myrrha 15 parts, Folium Nerviliae fordii 17 parts, Ramulus viticis negundo 16 parts, Folium et Fructus Helwingiae 17 parts, Herba Agrimoniae 19 parts, Herba Pyrolae 9 parts, Fructus Elaeagni 16 parts, Herba Hyperici perforati 23 parts, Rhizoma Polygoni Cuspidati 11 parts, Bark of Lindenleaf Torricellia 16 parts, Radix Ulmi Tonkinesis 20 parts, Folium Sennae 11 parts, Fructus Trichosanthis 19 parts, Fructus Cannabis 14 parts and 18 parts, Radix Glycyrrhizae.

7., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is ointment, its preparation method comprises the following steps:

8., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is spray, its preparation method comprises the following steps:

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

9., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is liniment, its preparation method comprises the following steps:

10., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is granule, its preparation method comprises the following steps: