CN104906502A

CN104906502A - Pharmaceutical composition for treatment of chicken damaged by heat and preparation method thereof

Info

Publication number: CN104906502A
Application number: CN201510249932.4A
Authority: CN
Inventors: 栾正庆; 黄河; 李鑫
Original assignee: Shandong New Hope Liuhe Group Co Ltd
Current assignee: Shandong New Hope Liuhe Group Co Ltd
Priority date: 2015-05-18
Filing date: 2015-05-18
Publication date: 2015-09-16

Abstract

The present invention discloses a pharmaceutical composition for treatment of chicken damaged by heat and a preparation method thereof, the pharmaceutical composition comprises the following raw material medicines: scutellaria baicalensis, gardenia, dendrobium, fructus aurantii, plaster, etrapanax papyriferus, bamboo shavings, honeysuckle, rhizoma anemarrhenae, radix ophiopogonis, golden cypress, commelina, herb of denseflower bulbophyllum, lotus plumule, licorice, frangrant daphne flower, privet leaves, coptis chinensis, zedoary, typha angustifolia root, veronica arvensis, balanophora harlandii Hook.f, rheum officinale, moth cocoon, smilax stans maxim, clematis glauca willd, eryngium foetidum and chamaerhodos erecta, the pharmaceutical composition has the effects of clearing heat and removing toxicity, purging fire, producing fluid and moistening, in the treatment of the chicken damaged by heat, chicken disease resistance can be improved, the immunity is enhanced, mortality is reduced, the cure rate is improved, compared with the treatment effect of traditional medicines, the treatment effect of the pharmaceutical composition is significantly improved, and the course of treatment is significantly shortened.

Description

A kind ofly be used for the treatment of pharmaceutical composition that chicken gets mildewed in warm conditions and preparation method thereof

Technical field

The present invention relates to Animal Medicine preparation technique field, be particularly a kind ofly used for the treatment of pharmaceutical composition that chicken gets mildewed in warm conditions and preparation method thereof.

Background technology

Chicken is got mildewed in warm conditions and to be evoked by chicken Salmonella of getting mildewed in warm conditions, and frequently dies young the pathological changes of the careful people and dysentery for characteristic, the popular disease of septic shown effect in young chicken and Adult Chicken with the essence such as liver, spleen.The symptom that chicken is got mildewed in warm conditions is: the energy that flashes before this is listless, and peel off solitary residence, not all right movement; Then head and wing sagging, cockscomb and wattle pale, feather is tightly controlled, and appetite is absolutely emerging, and the heart increases yearningly, and body temperature is reduced to 43-44 DEG C, and sick chicken squeezes yellowish green loose stool.The course of disease that chronic type chicken is got mildewed in warm conditions is about 2-10 days, normally less than 5 days.It is temporarily that the course of disease that slow sexual type chicken is got mildewed in warm conditions can delay several weeks.

" chicken spectrum " cloud: " husband's summer-heat person, hot person, the gas of the invisible Zhiyang in this world, rises to the order of long summer from ground vapour.Its gas too, then scorchingly steams cruel, has the gesture of so hot on stones that gold might have melted there, if the taking a disease unavoidably of sense.Though summer summer-heat, and the person of being heated, no matter four time all have it, only the moon in summer is more.Or shone full by sunlight because the shallow soil of grid is dry, without hiding part; Or because of its food quite well, to Xia Yueshang in addition savoury; Or do not separate because of group chicken, a place of being pushed here and there in a large crowd night, thermally gas fumes steams, and all hinders its heat also.Speech the moon in summer notably, cover because of the strong chicken of fat lump at the left hypochondrium, lose it and take good care of, therefore be subject to this disease also." warp " is said: " gas has Yu and instant heating." husband's gas is strong lights a fire, the reason of nature is also.If chicken is got mildewed in warm conditions, its head must swell, and " warp " is said: " head person is that convergence of all YANG meridians is first." on fire of moxibustion flame, and head thus swollen also; Or it is obstructed to have a stuffy nose, " warp " is said: " nose is the hole key of lung." lung governing qi, the deficiency of the lung is BITONG then, and excess of the lung is then had a stuffy nose; Or two look unfamiliar foam, all because of be heated very also.Or item contracting, tail hang down, excrement as eagle excrement person, all recuperate under medical treatment with rear ".

At present, western medical treatment chicken is got mildewed in warm conditions, main application antiviral, antibiotic etc are as ribavirin, penicillin, cephalo-type etc. and other chemosynthesis class antibacterials, life-time service, be easy to pathogenic strains is developed immunity to drugs, the property of medicine declines, and easily causes chicken drug residue to increase, and harm animal and human body is healthy.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition being used for the treatment of chicken and getting mildewed in warm conditions, this pharmaceutical composition has heat-clearing and toxic substances removing, pathogenic fire purging, to promote the production of body fluid the effect of moisturizing, while treatment chicken is got mildewed in warm conditions, the resistance against diseases of chicken can be improved, strengthen its immunity, reduce mortality rate, improve cure rate, relative to conventional medicament on therapeutic effect, there is significant improvement, obviously shorten and treat the course for the treatment of.

In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition being used for the treatment of chicken and getting mildewed in warm conditions, described pharmaceutical composition comprises following raw medicinal material: Radix Scutellariae, Fructus Gardeniae, Herba Dendrobii, Fructus Aurantii, Gypsum Fibrosum, Medulla Tetrapanacis, Caulis Bambusae In Taenia, Flos Lonicerae, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Cortex Phellodendri, Herba Commelinae, Herba Bulbophylli Odoratissim, Plumula Nelumbinis, Radix Glycyrrhizae, Flos daphnes odorae, the Folium Ligustri Lucidi, Rhizoma Coptidis, Rhizoma Curcumae, Rhizoma typhae, Herba veronicae arvensis, Herba balanophorae japonicae, Radix Et Rhizoma Rhei, Monema flavescens Walker, Rhizoma et radix smilacis santis, Herba Clematidis Glaucae, Herba eryngii foetidi and Herba Chamaerhodoris Erectae.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Scutellariae 10-25 weight portion, Fructus Gardeniae 10-18 weight portion, Herba Dendrobii 12-22 weight portion, Fructus Aurantii 11-21 weight portion, Gypsum Fibrosum 12-24 weight portion, Medulla Tetrapanacis 10-20 weight portion, Caulis Bambusae In Taenia 13-26 weight portion, Flos Lonicerae 14-26 weight portion, Rhizoma Anemarrhenae 10-30 weight portion, Radix Ophiopogonis 11-21 weight portion, Cortex Phellodendri 12-22 weight portion, Herba Commelinae 14-24 weight portion, Herba Bulbophylli Odoratissim 15-35 weight portion, Plumula Nelumbinis 10-26 weight portion, Radix Glycyrrhizae 13-27 weight portion, Flos daphnes odorae 12-22 weight portion, Folium Ligustri Lucidi 14-24 weight portion, Rhizoma Coptidis 11-23 weight portion, Rhizoma Curcumae 12-24 weight portion, Rhizoma typhae 12-26 weight portion, Herba veronicae arvensis 14-26 weight portion, Herba balanophorae japonicae 13-27 weight portion, Radix Et Rhizoma Rhei 12-24 weight portion, Monema flavescens Walker 3-5 weight portion, Rhizoma et radix smilacis santis 12-24 weight portion, Herba Clematidis Glaucae 11-21 weight portion, Herba eryngii foetidi 14-28 weight portion and Herba Chamaerhodoris Erectae 12-22 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Scutellariae 22 weight portion, Fructus Gardeniae 15 weight portion, Herba Dendrobii 14 weight portion, Fructus Aurantii 18 weight portion, Gypsum Fibrosum 24 weight portion, Medulla Tetrapanacis 12 weight portion, Caulis Bambusae In Taenia 15 weight portion, Flos Lonicerae 21 weight portion, the Rhizoma Anemarrhenae 25 weight portion, Radix Ophiopogonis 12 weight portion, Cortex Phellodendri 18 weight portion, Herba Commelinae 22 weight portion, Herba Bulbophylli Odoratissim 30 weight portion, Plumula Nelumbinis 26 weight portion, Radix Glycyrrhizae 17 weight portion, Flos daphnes odorae 14 weight portion, the Folium Ligustri Lucidi 22 weight portion, Rhizoma Coptidis 21 weight portion, Rhizoma Curcumae 12 weight portion, Rhizoma typhae 16 weight portion, Herba veronicae arvensis 24 weight portion, Herba balanophorae japonicae 25 weight portion, Radix Et Rhizoma Rhei 22 weight portion, Monema flavescens Walker 3 weight portion, Rhizoma et radix smilacis santis 14 weight portion, Herba Clematidis Glaucae 18 weight portion, Herba eryngii foetidi 24 weight portion and Herba Chamaerhodoris Erectae 16 weight portion.

Described pharmaceutical composition also comprises Carapax Trionycis, Indigo Naturalis, Radix Trichosanthis, Rhizoma Polygonati Odorati and Nidus Vespae.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Scutellariae 10-25 weight portion, Fructus Gardeniae 10-18 weight portion, Herba Dendrobii 12-22 weight portion, Fructus Aurantii 11-21 weight portion, Gypsum Fibrosum 12-24 weight portion, Medulla Tetrapanacis 10-20 weight portion, Caulis Bambusae In Taenia 13-26 weight portion, Flos Lonicerae 14-26 weight portion, Rhizoma Anemarrhenae 10-30 weight portion, Radix Ophiopogonis 11-21 weight portion, Cortex Phellodendri 12-22 weight portion, Herba Commelinae 14-24 weight portion, Herba Bulbophylli Odoratissim 15-35 weight portion, Plumula Nelumbinis 10-26 weight portion, Radix Glycyrrhizae 13-27 weight portion, Flos daphnes odorae 12-22 weight portion, Folium Ligustri Lucidi 14-24 weight portion, Rhizoma Coptidis 11-23 weight portion, Rhizoma Curcumae 12-24 weight portion, Rhizoma typhae 12-26 weight portion, Herba veronicae arvensis 14-26 weight portion, Herba balanophorae japonicae 13-27 weight portion, Radix Et Rhizoma Rhei 12-24 weight portion, Monema flavescens Walker 3-5 weight portion, Rhizoma et radix smilacis santis 12-24 weight portion, Herba Clematidis Glaucae 11-21 weight portion, Herba eryngii foetidi 14-28 weight portion, Herba Chamaerhodoris Erectae 12-22 weight portion, Carapax Trionycis 10-20 weight portion, Indigo Naturalis 11-22 weight portion, Radix Trichosanthis 10-26 weight portion, Rhizoma Polygonati Odorati 14-28 weight portion and Nidus Vespae 10-18 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Scutellariae 22 weight portion, Fructus Gardeniae 16 weight portion, Herba Dendrobii 14 weight portion, Fructus Aurantii 20 weight portion, Gypsum Fibrosum 22 weight portion, Medulla Tetrapanacis 10 weight portion, Caulis Bambusae In Taenia 24 weight portion, Flos Lonicerae 20 weight portion, the Rhizoma Anemarrhenae 30 weight portion, Radix Ophiopogonis 11 weight portion, Cortex Phellodendri 16 weight portion, Herba Commelinae 22 weight portion, Herba Bulbophylli Odoratissim 32 weight portion, Plumula Nelumbinis 24 weight portion, Radix Glycyrrhizae 25 weight portion, Flos daphnes odorae 14 weight portion, the Folium Ligustri Lucidi 24 weight portion, Rhizoma Coptidis 16 weight portion, Rhizoma Curcumae 22 weight portion, Rhizoma typhae 26 weight portion, Herba veronicae arvensis 20 weight portion, Herba balanophorae japonicae 27 weight portion, Radix Et Rhizoma Rhei 14 weight portion, Monema flavescens Walker 3 weight portion, Rhizoma et radix smilacis santis 16 weight portion, Herba Clematidis Glaucae 21 weight portion, Herba eryngii foetidi 28 weight portion, Herba Chamaerhodoris Erectae 20 weight portion, Carapax Trionycis 15 weight portion, Indigo Naturalis 14 weight portion, Radix Trichosanthis 26 weight portion, Rhizoma Polygonati Odorati 28 weight portion and Nidus Vespae 14 weight portion.

The dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

The dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, Monema flavescens Walker, Rhizoma et radix smilacis santis, Herba Clematidis Glaucae, Herba eryngii foetidi and Herba Chamaerhodoris Erectae are mixed in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Herba Bulbophylli Odoratissim, Plumula Nelumbinis, Radix Glycyrrhizae, Flos daphnes odorae, the Folium Ligustri Lucidi, Rhizoma Coptidis, Rhizoma Curcumae He Rhizoma typhae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The invention has the beneficial effects as follows: this pharmaceutical composition has heat-clearing and toxic substances removing, pathogenic fire purging, to promote the production of body fluid the effect of moisturizing, while treatment chicken is got mildewed in warm conditions, the resistance against diseases of chicken can be improved, strengthen its immunity, reduce mortality rate, improve cure rate, relative to conventional medicament on therapeutic effect, there is significant improvement, obviously shorten and treat the course for the treatment of.

detailed description of the invention:

Pharmaceutical composition of the present invention is with heat-clearing and toxic substances removing, pathogenic fire purging, promote the production of body fluid and moisturize for primary treatment principle, provide a kind of pharmaceutical composition being used for the treatment of chicken and getting mildewed in warm conditions, comprise following raw medicinal material: Radix Scutellariae, Fructus Gardeniae, Herba Dendrobii, Fructus Aurantii, Gypsum Fibrosum, Medulla Tetrapanacis, Caulis Bambusae In Taenia, Flos Lonicerae, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Cortex Phellodendri, Herba Commelinae, Herba Bulbophylli Odoratissim, Plumula Nelumbinis, Radix Glycyrrhizae, Flos daphnes odorae, the Folium Ligustri Lucidi, Rhizoma Coptidis, Rhizoma Curcumae, Rhizoma typhae, Herba veronicae arvensis, Herba balanophorae japonicae, Radix Et Rhizoma Rhei, Monema flavescens Walker, Rhizoma et radix smilacis santis, Herba Clematidis Glaucae, Herba eryngii foetidi, Herba Chamaerhodoris Erectae, Carapax Trionycis, Indigo Naturalis, Radix Trichosanthis, Rhizoma Polygonati Odorati and Nidus Vespae.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

Radix Scutellariae: property is bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Radix Scutellariae has antipyretic, calm, blood pressure lowering, diuresis, reduction capillary permeability, suppresses the effects such as intestinal motility, to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery coccus, newcastle, bacillus pyocyaneus, there is certain inhibitory action, have good curative effect to upper respiratory tract infection, chronic bronchitis, bacillary dysentery etc.

Nidus Vespae: sweet is flat.Return stomach warp.Function cures mainly: dispel the wind, merit poison, parasite killing, pain relieving.For toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot.

Fructus Gardeniae: bitter, cold, nontoxic; Enter heart channel, Liver Channel, lung meridian, stomach warp, tri-jiao channel.Shennong's Herbal: " pathogen in main five, pathogenic heat in the stomach gas, flushed complexion wine acne vulgaris nose, the red impetigo infections of tuberculoid leprosy." " Mingyi Bielu ": " Great Cold, nontoxic.Cure mainly the hot swelling pain of order, the large heat of breast heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas." pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling blood for hemostasis.Calentura is vexed, liver-fire conjunctival congestion, and headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprains and swell and ache.This product bitter cold is fallen clearly, can rush down clearly three burnt pathogenic fire, eliminating heart-fire and relieving restlessness, the key medicine that calentura is vexed in order to control, restlessness is not peaceful.There is effect of sharp clearly part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels dampness-heat in the liver and gallbladder, the jaundice of available treating the liver gallbladder retention and fumigation of damp-heat inside the body, oliguria with reddish urine person.The hypotensive activity position of Fructus Gardeniae, at maincenter, mainly strengthens caused by medulla oblongata parasympathetic maincenter tensity.

Herba Dendrobii: cold nature, sweet in the mouth, returns stomach, kidney channel, has reinforcing stomach reg fluid, effect of nourishing YIN and clearing away heat.Cure mainly cloudy impairment of body fluid to lose, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, the cards such as poor vision.Herba Dendrobii can significantly improve superoxides discrimination China enzyme (SOD) level, reduces lipid peroxide (LPO), regulates brain monoaminergic transmitters level, suppresses similar monoamine oxidase, MAO (MAO), play the effect of slow down aging.Herba Dendrobii contains lactone component, has the condensation of blood circulation promoting and blood stasis dispelling, blood vessel dilating and antiplatelet, and treatment embolic occlusion pulse tube is scorching, cerebral thrombosis, the effects such as arteriosclerotic obliteration.

Cortex Phellodendri: nature and flavor bitter cold, has heat clearing and damp drying, pathogenic fire purging removes steams, effect of detoxification sore treatment.Be usually used in damp-heat dysentery, jaundice, leucorrhea and the disease such as pyretic arthralgia, pyretic stranguria.Modern study shows, Cortex Phellodendri is containing the main component such as berberine, obacunone, and have the effect of antibacterial, convergence, antiinflammatory, to symptoms such as various skin noxious dampness, skin infection, effect is good." herbal classic is met former " is said: " Cortex Phellodendri, raw with falling excess-fire, processed with wine is controlled in YIN-fire scorching, and salt system controls the inferior the fire of Jiao, and processed with Rhizoma Zingiberis Recens controls middle burnt phlegm-fire, and Sucus Zingberis is fried and blackly controlled damp and hot, and black asthenic fire processed fried by salt wine, deficiency of YIN fire Sheng flushed complexion floating YANG, Radix Aconiti Lateralis Preparata juice system ".

Rhizoma Polygonati Odorati: nature and flavor: sweet, is slightly cold.Gui Jing: attach to the lung and stomach meridians.Cure mainly: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.

Fructus Aurantii: dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.1. " property of medicine opinion ": control rubella all over, dislike and itch, main hemorrhoidal hamorrhage haemorrhoids, stagnation of QI in chest and abdomen in flesh as numb bean, the swollen void of two sides of body, pass diaphragm is congested.2. " Japan hanako materia medica ": spleen benefiting and stimulating the appetite, adjust the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, preventing or arresting vomiting is inverse, expectorant.Control regurgitation, cholera dysentery, helps digestion, and broken crux mass beside the umbilicus, five types of dysphagia, except wind improving eyesight and lung qi edema, sharp intestine and small intestine, skin is itched.Swollen can the processing of hemorrhoid is pressed.3. " Kaibao Bencao ": main air is itched paralysis, easing joint movement, consumptive disease is coughed, and back of the body arm is bored and listless, loosely stays knot, chest and diaphragm expectorant stagnant, and relieve oedema or abdominal distension through diuresis or purgation, full, the large hemorrhoidal hamorrhage of relieving distension, peace stomach, only wind bitterly.4. " pearl sac ": dispelling the stagnated QI, gas unfavorable in lung is let out.5. " medicine origin ": " curing mainly secret formula " cloud, broken hardness in the epigastrium painful abdominal mass, profit is gas in the heart, reduces phlegm, and 6. help digestion " detailed outline ": control tenesmus.

Gypsum Fibrosum: pungent, sweet, is slightly cold.Attach to the lung and stomach meridians.Cure mainly apoplexy cold and heat, heart subinverse gas is frightened to be breathed heavily, and xerostomia scorching tongue, can not cease, hardness and fullness in the abdomen pain, evil removing ghost, puerperium incised wound.Except seasonal epidemic pathogens headache fever of the body, three burnt large heat, skin heat, stagnation of QI in the intestines and stomach, expelling pathogenic factors from muscles by diaphoresis, restlessness accompanied by ascending of QI of only quenching one's thirst, the sudden and violent gas of abdominal distention, pharynx heat of panting, except gastric heat lung-heat, loose YIN pathogen, slow spleen QI invigorating.Only Yangming Channel headache, fever with chills, day feeds hectic fever, and drinking a large amount of water due to extreme thirst, heatstroke hectic fever, has a toothache.Gypsum Fibrosum is also known as Pu Yangyu, cold in nature, and the Pu Yang jade pillow using Gypsum Fibrosum to grind can raise with cold gram thermal control blood pressure, adheres to that blood pressure progressively can be reduced to normal level by use.

Indigo Naturalis: nature and flavor: salty, cold.Gui Jing: return Liver Channel.Cure mainly: heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.For maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.

Rhizoma Coptidis: (root) is bitter, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel." Yaoxing Fu ": " bitter in the mouth, flat, gas is trembled with fear, nontoxic.Sink also, the moon also.It is with having four: eliminating heart-fire, the shape of the epigastric fullness that disappears; Main intestinal Bleach is red except what mix in intestinal; Control order disease to break out and should use, treat skin infection head and the tail all same." function heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, is longer than the fire of removing pathogen in the heart stomach, and have preventing or arresting vomiting concurrently and to disappear the merit of painful abdominal mass, can be used for the prosperous caused dysphoria and insomnia for the treatment of heart-fire, heat in blood tells nosebleed, conjunctival congestion, has a toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.

Radix Et Rhizoma Rhei: bitter, cold; Return spleen, stomach, large intestine, Liver Channel.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.

Carapax Trionycis: nature and flavor: salty, is slightly cold.Gui Jing: return liver, kidney channel.Curing mainly: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, bringing down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea ， WEIJIA, chronic malaria malaria with splenomegaly.

Medulla Tetrapanacis: bitter, cold in nature; Enter heart channel, small intestine meridian, urinary bladder channel.Collective Notes to the Canon of Materia medica: " Medulla Tetrapanacis, the present goes out shortcut, raw around timbo, and juice is white, and stem has pore, and two is all logical, blows it containing one, then to go out those persons good for gas.Or cloud and Weed rattan." " property of medicine opinion ": " cure mainly five types of stranguria, diuresis, switch lattice.Control people to sleep, main edema is floating large, heat clearing away and restlessness relieving more." function inducing diuresis for treating stranguria syndrome, clear away heart-fire relieving restlessness, stimulating milk secretion of stimulating the menstrual flow.For stranguria, edema, vexed dark coloured urine, amenorrhea breast is few, damp and hot arthralgia pain.This product energy inducing diuresis to remove edema, lower dampness removing heat, makes that damp and hot heresy is descending discharges from urine.

Caulis Bambusae In Taenia: cold nature, sweet in the mouth; Enter lung, stomach warp." book on Chinese herbal medicine is new again ": " reduce phlegm removing heat from blood for pathogenic fire purging relieving restlessness, lung moistening dissipating depression of QI, emesis blood, Removing Blood Stasis, eliminating carbuncle flaccidity toxic swelling." " detailed outline ": " cure the wound cold recurrence caused by overexertion, little Re Epilepsy, married woman's fetal movement." " book on Chinese herbal medicine is just ": " control consumptive lung disease saliva expectorant, hematuria, married woman's heat in blood collapses pouring, fetal movement, and children's wind-heat epilepsy, mental disorder is breathed with cough, and little hydro-thermal is puckery." function removing heat-phlegm, relieve restlessness and prevent vomiting.Expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement is held under the arm for phlegm-heat cough, gallbladder fire.

Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have infection effect to old man and child.So, often take Flos Lonicerae soak or decoct be conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the hypertensive treatment of liver-heat disease regulating liver-QI pattern of fever and rehabilitation.Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, leukocytic phagocytic function can be promoted, there is stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, newcastle, bacillus pyocyaneus, tubercule bacillus etc.In addition Flos Lonicerae also have function of gallbladder promoting to protect the liver, antioxidation, blood fat reducing, the effect such as central excitation.

The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enters lung, stomach, kidney channel, has relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, and cure mainly fever caused by exogenous pathogenic factors, high heat is irritated, lung-heat type cough, and interior-heat such as to be quenched one's thirst at the symptom; Its bitter cold matter is moistened, and property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also diabetes is used for the treatment of; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire.The Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.

Radix Ophiopogonis: sweet, the micro-hardship of property, is slightly cold; GUIXIN, lung, stomach warp.Have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, can be used for sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation etc.Clear the moon of supporting lung stomach goes heart use more, and YIN nourishing clears away heart-fire the use that connects with the heart more.These product are sweet cold clear and rich, and be apt to control deficiency of stomach-Yin, dry tongue is thirsty, indigestion and loss of appetite not hungry card such as grade.In addition, also availablely deficiency of YIN dryness of the intestine is controlled, constipation person.Modern study shows, can improve immunologic function Radix Ophiopogonis, various bacteria be had to inhibitory action, can strengthen pituitary adrenal system function, improve organism adaptation ability.

Herba Commelinae: sweet, cold, light; Enter the heart, all warps of liver,spleen,kidney, intestine and small intestine.Supplement to the Herbal: " fourth swells, and meat disease is not smooth, infantile erysipelas, mad epilepsy of generating heat, large abdomen feeling of fullness, body face edema due to disorder of QI, and hematodiarrhoea, dog stings Serpentis, the poison such as carbuncle for main cold and heat subtertian malaria, phlegm retention." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " invigorating QI and blood is treated married woman leucorrhea, redly to be collapsed, tissue regeneration promoting blood, only hematuria, epistaxis blood, stranguria with blood." for fever caused by exogenous pathogens, or febrile disease heating is not moved back, or laryngopharynx swelling and pain, and the disease such as carbuncle skin infection.For dysuria, edema, or wet into diseases such as bet bladder, the puckery pains of dribbling urination.The water logging agent of congener stem and leaf or decoct can excited uterus, collapsible tube, and can clotting time be shortened.

Herba Bulbophylli Odoratissim: nature and flavor: sweet, light is flat.Cure mainly: moistening the lung and resolving phlegm, relaxing muscles and tendons and activating QI and blood in the collateral, antiinflammatory.For hemoptysis of pulmonary tuberculosis, chronic tracheitis, chronic pharyngitis, rheumatism bones and muscles pain; Fracture is controlled in external, and traumatic injury is dampened, knife injury.

Plumula Nelumbinis: bitter, cold, nontoxic.Enter the heart, lung, kidney three warp." feeding habits book on Chinese herbal medicine ": " be rawly taken as end, adjust lower three money with rice drink, treat thirst due to hemorrhage disease, puerperal thirsty disease." " this leather is new again ": " clearing away heart-fire, suppressing the hyperactive liver fire, lung-fire, falls in purgation of spleen excess fire.Relieve summer heat relieving restlessness, promoting the production of body fluid to quench thirst, controls order redness." " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases ": " Plumula Nelumbinis, walks kidney by the heart, leads in kidney under making heart-fire, and winding rises again, and kidney tide waterborne can be made in the heart." for calentura, vexed coma, summer-heat excessive thirst, hypertension, dysphoria with smothery sensation is had a sleepless night.Among the people conventional with drink of making tea, there is clearing away heart-fire, the effect of only passing out semen, to the insomniac of disarmony between the heart and kidney, hyperactivity of fire caused by deficiency of YIN, food the most suitable.Well go effect of heart-fire in addition, can aphtha of the mouth and tongue be treated, and conduce to sleep.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, have good effects to chronic adrenocortical hypofunction; Glycyrrhiza preparation can promote stomach mucus to be formed and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, be usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; Radix Glycyrrhizae is also one of primary raw material of rendan mini-pills.

Herba Clematidis Glaucae: nature and flavor: pungent, temperature.Cure mainly: wind-damp dispelling, antipruritic.Control chronic rheumatic arthritis, dyspepsia, vomiting, acute appendicitis, furuncle, pruritus.

Flos daphnes odorae: nature and flavor: Jiangxi " medical herbs handbook ": " sweet-salty." cure mainly: control laryngopharynx swelling and pain, toothache, rheumatalgia.1. " property of medicine is examined ": " the clear sharp head, toothache should contain." 2. " detailed outline is picked up any lost article from the road ": " rare pox, control breast carcinoma from the beginning of."

Herba Acroptili repentis: cure mainly: " Chinese Herbal Medicine in Xinjiang handbook ": " heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Control carbuncle furuncle, innominate toxic swelling, arthritis.

The Folium Ligustri Lucidi: nature and flavor: " detailed outline ": " micro-hardship, flat, nontoxic." cure mainly: dispel the wind, improving eyesight, detumescence, pain relieving.Control head's dusk pain, wind heat is red follows, skin ulcer turgescence canker, scalds, stomatitis.1. " detailed outline ": " except wind falls apart blood, subduing swelling and relieving pain.Control head's dusk pain, all malignant boil swell, and top gem of a girdle-pendant skin ulcer is festered, person of a specified duration with decocting in water, take advantage of heat posted it, again and again change easily, rice vinegar boils also can.Aphtha of the mouth and tongue, glossoncus expansion, smashes juice impregnation salivation." 2. " Guizhou side among the people medicine collection ": " external application is only hemorrhage due to wound, and anti-inflammation detumescence, controls burn.Take orally and can cough-relieving cough, emesis blood." Radix Aristolochiae yunnanensis: nature and flavor: bitter, temperature.Cure mainly: regulating QI to relieve pain, expelling wind and activating blood circulation.For stomachache, abdominal distention, stomachache, dyspepsia, rheumatic ostalgia, traumatic injury.

Rhizoma Curcumae: source: Hou Ningji " medicine spectrum ".Nature and flavor: toil, temperature.1. " Kaibao Bencao ": " bitter in the mouth is pungent; Temperature, nontoxic." 2. " medicine origin ": " bitter in the mouth is flat." return through: enter liver, spleen channel.1. " Thunder God concocts property of medicine solution ": " enter lung, spleen two warp." 2. " book on Chinese herbal medicine converges and says ": " enters liver channel of foot-Jueyin." 3. " book on Chinese herbal medicine is new again ": " enters the heart, kidney two warp." cure mainly: circulation of qi promoting, removing blood stasis, removing food stagnancy, pain relieving.Control trusted subordinate's distending pain, lump in the abdomen, gather, dyspepsia does not disappear, and women's blood stasis amenorrhea, traumatic injury is had a pain."

Rhizoma typhae: source: " detailed outline ".Nature and flavor: sweet are cool.1. " herbal classic ": " sweet in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. " classifying herbal ": " is bitter, cool." cure mainly: clearing away heat and cooling blood, inducing diuresis to remove edema.Control anemia of pregnant woman's consumptive fever, vaginal bleeding due to excessive movement of fetus, quench one's thirst, aphtha, hematodiarrhoea, gonorrhea, leucorrhea, edema, scrofula.1. " herbal classic ": " pathogen under the main the five internal organs heart, rotten smelly in mouth, hard tooth, improving eyesight, audition improvement." 2. " daily book on Chinese herbal medicine ": " reduces phlegm and internal heat dry, diuresis." 3. Wang Ying " food book on Chinese herbal medicine ": " is raw to be eaten, and only quenches one's thirst." 4. Yao can become " food book on Chinese herbal medicine ": ' be lower profit cough only, and lung qi is panted sleeplessness." 5. " occupying diet spectrum with breath ": " heat clearing away, nourishes blood, and eliminating carbuncle, throat, logical two just." 6. " Kaibao Bencao ": " controls pouring drop, damp-edema." 7. " Traditional Chinese Medicine in Sichuan will ": " consumer edema, water amasss, and only toothache."

Herba veronicae arvensis: source: " illustrated handbook planted by middle traditional Chinese medicines ".Cure mainly: " illustrated handbook planted by middle traditional Chinese medicines ": " treating malaria disease."

Herba balanophorae japonicae: source: " detailed outline is picked up any lost article from the road ".Nature and flavor: bitter sweet, cool.1. " detailed outline ": " bitter sweet, nontoxic."

2. " detailed outline is picked up any lost article from the road ": " cool in nature." 3. " Traditional Chinese Medicine in Sichuan will ": " puckery is bitter, cold in nature, nontoxic." cure mainly: heat clearing away, removing toxic substances, relieving alcoholic intoxication.Control wind heat skin eruption, cough due to lung-heat spits blood, metrorrhagia, hemorrhoid.1. " detailed outline ": " relieving alcoholic intoxication is controlled wine and amassed." 2. " detailed outline is picked up any lost article from the road ": " expelling pathogenic factors from muscles heat, loose wind-fire and positive bright wind heat skin eruption." 3. " Traditional Chinese Medicine in Sichuan will ": " clearing away lung-heat, relieving heat toxin.Control cough to spit blood, metrorrhagia and swelling and pain of hemorrhoid." 4. " Hunan medicine will ": " refers to raw snake head-like infection, and child penis swells, and mashes deposited affected part."

Monema flavescens Walker: source: " herbal classic ".Nature and flavor: 1. " herbal classic ": " sweet in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. " Japan hanako materia medica ": " is poisonous." cure mainly: control infantile convulsion, infantum tetanus, epilepsy disease.1. " herbal classic ": " main pediatric epilepsy scared, cold and heat stagnation of QI." 2. supplement to the Herbal: " main children's's locked jaw is sick, and first superfluous children's's mouth is close to, and blood is shown in order, is coated with it with the broken extracting juice of urn, and also life smashes Armadillidium and the painting of Monema flavescens Walker juice."

Rhizoma et radix smilacis santis: source: " Gansu Chinese herbal medicine handbook ".Nature and flavor: 1. " Gansu Chinese herbal medicine handbook ": " pungent salty, temperature." 2. " Henan economic plants will ": " bitter in the mouth, property is put down, nontoxic." cure mainly: expelling wind and removing dampness, activating blood cirulation to regulate QI flow, pain relieving.Dispelling the wind and dampness pathogens pain, traumatic injury, traumatic hemorrhage, fishbone bone stuck in the throat.1. " Gansu Chinese herbal medicine handbook ": " expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.Dispelling the wind and dampness pathogens waist knee joint limbs pain is not healed for a long time, fishbone bone stuck in the throat." 2. " Henan economic plants will ": " promoting blood circulation and stopping pain.Control injured, wound." 3. " China's economic flora ": " pleasant analgesia."

Herba eryngii foetidi: source: " Luchuan book on Chinese herbal medicine ".Nature and flavor: " Luchuan book on Chinese herbal medicine ": " pungent, temperature." curing mainly: 1. " Luchuan book on Chinese herbal medicine ": " circulation of qi promoting, stomach invigorating.Control abdominal distention, dyspepsia." 2. Guangzhou army " conventional Chinese herbal medicine handbook ": " dispelling wind heat extraction, fragrant stomach invigorating.Cure cold chest pain, dyspepsia, enteritis, diarrhea, venom."

Herba Chamaerhodoris Erectae: nature and flavor: bitter in the mouth is micro-pungent, warm in nature.Cure mainly: wind-damp dispelling.

Radix Trichosanthis: nature and flavor: sweet, micro-hardship, is slightly cold.Gui Jing: attach to the lung and stomach meridians.Cure mainly: clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 pharmaceutical composition 1

Embodiments provide a kind of pharmaceutical composition being used for the treatment of chicken and getting mildewed in warm conditions, be made up of the raw medicinal material of following parts by weight: Radix Scutellariae 22 weight portion, Fructus Gardeniae 15 weight portion, Herba Dendrobii 14 weight portion, Fructus Aurantii 18 weight portion, Gypsum Fibrosum 24 weight portion, Medulla Tetrapanacis 12 weight portion, Caulis Bambusae In Taenia 15 weight portion, Flos Lonicerae 21 weight portion, the Rhizoma Anemarrhenae 25 weight portion, Radix Ophiopogonis 12 weight portion, Cortex Phellodendri 18 weight portion, Herba Commelinae 22 weight portion, Herba Bulbophylli Odoratissim 30 weight portion, Plumula Nelumbinis 26 weight portion, Radix Glycyrrhizae 17 weight portion, Flos daphnes odorae 14 weight portion, the Folium Ligustri Lucidi 22 weight portion, Rhizoma Coptidis 21 weight portion, Rhizoma Curcumae 12 weight portion, Rhizoma typhae 16 weight portion, Herba veronicae arvensis 24 weight portion, Herba balanophorae japonicae 25 weight portion, Radix Et Rhizoma Rhei 22 weight portion, Monema flavescens Walker 3 weight portion, Rhizoma et radix smilacis santis 14 weight portion, Herba Clematidis Glaucae 18 weight portion, Herba eryngii foetidi 24 weight portion and Herba Chamaerhodoris Erectae 16 weight portion.

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.7 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 32 hours under the condition of 10 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 0.7 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 17g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.22 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 1 pharmaceutical composition 2

Embodiments provide a kind of pharmaceutical composition being used for the treatment of chicken and getting mildewed in warm conditions, be made up of the raw medicinal material of following parts by weight: Radix Scutellariae 22 weight portion, Fructus Gardeniae 16 weight portion, Herba Dendrobii 14 weight portion, Fructus Aurantii 20 weight portion, Gypsum Fibrosum 22 weight portion, Medulla Tetrapanacis 10 weight portion, Caulis Bambusae In Taenia 24 weight portion, Flos Lonicerae 20 weight portion, the Rhizoma Anemarrhenae 30 weight portion, Radix Ophiopogonis 11 weight portion, Cortex Phellodendri 16 weight portion, Herba Commelinae 22 weight portion, Herba Bulbophylli Odoratissim 32 weight portion, Plumula Nelumbinis 24 weight portion, Radix Glycyrrhizae 25 weight portion, Flos daphnes odorae 14 weight portion, the Folium Ligustri Lucidi 24 weight portion, Rhizoma Coptidis 16 weight portion, Rhizoma Curcumae 22 weight portion, Rhizoma typhae 26 weight portion, Herba veronicae arvensis 20 weight portion, Herba balanophorae japonicae 27 weight portion, Radix Et Rhizoma Rhei 14 weight portion, Monema flavescens Walker 3 weight portion, Rhizoma et radix smilacis santis 16 weight portion, Herba Clematidis Glaucae 21 weight portion, Herba eryngii foetidi 28 weight portion, Herba Chamaerhodoris Erectae 20 weight portion, Carapax Trionycis 15 weight portion, Indigo Naturalis 14 weight portion, Radix Trichosanthis 26 weight portion, Rhizoma Polygonati Odorati 28 weight portion and Nidus Vespae 14 weight portion.

The first step, mixes Monema flavescens Walker, Rhizoma et radix smilacis santis, Herba Clematidis Glaucae, Herba eryngii foetidi and Herba Chamaerhodoris Erectae in described ratio, and be the dissolve with ethanol of 85% with the determining alcohol of 4 times relative to the mixture quality obtained, reflux was extracted after 3 hours, filters, obtains the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 90% of 2 times relative to the mixture quality obtained, reflux was extracted after 1.5 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Herba Bulbophylli Odoratissim, Plumula Nelumbinis, Radix Glycyrrhizae, Flos daphnes odorae, the Folium Ligustri Lucidi, Rhizoma Coptidis, Rhizoma Curcumae He Rhizoma typhae are mixed in described ratio, add the ethanol of the determining alcohol 90% of 3 times relative to the mixture quality obtained, heating and refluxing extraction 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the mastic of 1.21, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 3 times relative to the mixture quality obtained, and heating decoction 4 hours, filters; By filtering residue again with the water dissolution of 2 times relative to the mixture quality obtained, again heat decoction 1.5 hours, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 100 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The toxicity test of pharmaceutical composition:

1, trial drug

Choose Radix Scutellariae 22g, Fructus Gardeniae 15g, Herba Dendrobii 14g, Fructus Aurantii 18g, Gypsum Fibrosum 24g, Medulla Tetrapanacis 12g, Caulis Bambusae In Taenia 15g, Flos Lonicerae 21g, Rhizoma Anemarrhenae 25g, Radix Ophiopogonis 12g, Cortex Phellodendri 18g, Herba Commelinae 22g, Herba Bulbophylli Odoratissim 30g, Plumula Nelumbinis 26g, Radix Glycyrrhizae 17g, Flos daphnes odorae 14g, Folium Ligustri Lucidi 22g, Rhizoma Coptidis 21g, Rhizoma Curcumae 12g, Rhizoma typhae 16g, Herba veronicae arvensis 24g, Herba balanophorae japonicae 25g, Radix Et Rhizoma Rhei 22g, Monema flavescens Walker 3g, Rhizoma et radix smilacis santis 14g, Herba Clematidis Glaucae 18g, Herba eryngii foetidi 24g and Herba Chamaerhodoris Erectae 16g mix, and is ground into powder; Added by acquisition powder in 1800g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1800g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.

2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

Clinical experiment:

Liaocheng of Shandong Province chicken plant, in by the end of July, 2012, and find the young chicken of 450 100 ages in days nearly, the energy that flashed before this is listless, and peel off solitary residence, not all right movement; Then head and wing sagging, cockscomb and wattle pale, feather is tightly controlled, appetite is absolutely emerging, and the heart increases yearningly, and body temperature is reduced to 43-44 DEG C, sick chicken squeezes yellowish green loose stool, even occur dead young chicken, young for death chicken is dissected visible liver, splenomegaly 3 times, and liver appearance is bronze-colored, liver and cardiac muscle there is the downright bad face of goldenrod, Gallbladder enlargement, is covered with green oil bile, accidentally can see pericardium and one's mind is pure adhesion.According to above-mentioned epidemiology with analyse and be diagnosed as chicken and get mildewed in warm conditions.

Choose the ill young chicken 120 that 100 ages in days are made a definite diagnosis, 120 ill chickens are divided into two groups at random, are respectively embodiment group and matched group, the ill young chicken of two groups all without significant difference, has comparability in body weight, the state of an illness etc.The powder that embodiment group and matched group use the embodiment of the present invention 2 to obtain respectively and conventional feed feed ill young chicken, and wherein, powder, according in the weight ratio conventional feed of 0.3g:40g, is fed 6 days continuously; Matched group also needs to carry out conventional therapy and subcutaneous injection hyper-immune serum 0.2 milliliter, continuously treatment 6 days.Take each group of ill chicken body weight respectively before and after experiment, period records average weight and the average daily gain of ill chicken, recovery from illness number and cure rate situation, and the time of curing number compares, and result is respectively as shown in table 1, table 2 and table 3.Wherein, cure: energy is full, is ready to live in groups, normal walking and movement; Head and wing recover as Healthy Youth chicken, and cockscomb and wattle recover normal, and feather relax degree of having, appetite increase, and temperature recovery normally, does not squeeze the phenomenon of yellowish green loose stool; It is normal that histoorgan such as inspection liver, spleen etc. is cutd open in sampling; Invalid: clinical symptoms is not improved and even increased the weight of or death.

Table 1 is the young chicken average weight synopsis of group respectively

Data from table 1: compared with matched group, use the young chicken that pharmaceutical composition of the present invention is fed, and the young chicken that its average weight is fed than conventional medicament exceeds 93.5g, and average daily gain exceeds 20.52g/d.

The therapeutic effect synopsis of young chicken respectively organized by table 2

Data from table 2: compared with conventional medicament, the pharmaceutical composition of the embodiment of the present invention 2 has advantage that is evident in efficacy, cheap, that have no side effect in treatment chicken is got mildewed in warm conditions.

Known by contrast test: ill young chicken average weight, the cure rate of the pharmaceutical composition nursing of the embodiment of the present invention 2 are all better than matched group, namely pharmaceutical composition of the present invention can not only be treated chicken and got mildewed in warm conditions, the nutritional need of young chicken can also be met, be specially adapted to suffer from the nutritional need that chicken is got mildewed in warm conditions.

The time comparative example (%) of curing number for 6 days afterwards treated respectively by table 3 respectively group

Data from table 3: pharmaceutical composition of the present invention is got mildewed in warm conditions to treatment chicken, relative to conventional medicament on therapeutic effect, has significant improvement, obviously shortens and treats the course for the treatment of.

Model case

The young chicken of 300 100 ages in days of in January, 2014 Taian Shandong poultry smallholder operating, the energy that flashed before this by more than 100 young chickens is listless, and peel off solitary residence, not all right movement; Then head and wing sagging, cockscomb and wattle pale, feather is tightly controlled, appetite is absolutely emerging, and the heart increases yearningly, and body temperature is reduced to 43-44 DEG C, sick chicken squeezes the symptoms such as yellowish green loose stool, select a wherein seriously ill young chicken to dissect, find liver, splenomegaly 4 times, liver appearance is bronze-colored, liver and cardiac muscle there is the downright bad face of goldenrod, Gallbladder enlargement, is covered with green oil bile, accidentally can see pericardium and one's mind is pure adhesion.The pathological material of disease such as liver, spleen getting ill young chicken shreds grinding, does 1: 5 be diluted to suspension, after adding penicillin and streptomycin process with sterile saline, be inoculated in the Embryo Gallus domesticus chorioallantoic cavity of 14 ages in days, every egg inoculation 0.5ml, after 3-5 days, chicken embryo death, cut open the dead Embryo Gallus domesticus of inspection, find liver, splenomegaly 4 times, liver appearance is bronze-colored, liver and cardiac muscle there is the downright bad face of goldenrod, Gallbladder enlargement, is covered with green oil bile, accidentally can see pericardium and one's mind is pure adhesion.Place is raised immediately by not occurring that the young chicken of symptom isolates.Choose 50 ill young chickens wherein, the pharmaceutical composition of the embodiment of the present invention 2 that starts to feed, feed 6 days continuously, within 1st day, ill young chicken symptom is obviously improved, and within the 2nd day, 50 young chickens are all fully recovered, after continuing to feed 4 days, compared with Healthy Youth chicken, average weight increases.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. the pharmaceutical composition being used for the treatment of chicken and getting mildewed in warm conditions, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Radix Scutellariae, Fructus Gardeniae, Herba Dendrobii, Fructus Aurantii, Gypsum Fibrosum, Medulla Tetrapanacis, Caulis Bambusae In Taenia, Flos Lonicerae, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Cortex Phellodendri, Herba Commelinae, Herba Bulbophylli Odoratissim, Plumula Nelumbinis, Radix Glycyrrhizae, Flos daphnes odorae, the Folium Ligustri Lucidi, Rhizoma Coptidis, Rhizoma Curcumae, Rhizoma typhae, Herba veronicae arvensis, Herba balanophorae japonicae, Radix Et Rhizoma Rhei, Monema flavescens Walker, Rhizoma et radix smilacis santis, Herba Clematidis Glaucae, Herba eryngii foetidi and Herba Chamaerhodoris Erectae.

2. the pharmaceutical composition being used for the treatment of chicken and getting mildewed in warm conditions according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Scutellariae 10-25 weight portion, Fructus Gardeniae 10-18 weight portion, Herba Dendrobii 12-22 weight portion, Fructus Aurantii 11-21 weight portion, Gypsum Fibrosum 12-24 weight portion, Medulla Tetrapanacis 10-20 weight portion, Caulis Bambusae In Taenia 13-26 weight portion, Flos Lonicerae 14-26 weight portion, Rhizoma Anemarrhenae 10-30 weight portion, Radix Ophiopogonis 11-21 weight portion, Cortex Phellodendri 12-22 weight portion, Herba Commelinae 14-24 weight portion, Herba Bulbophylli Odoratissim 15-35 weight portion, Plumula Nelumbinis 10-26 weight portion, Radix Glycyrrhizae 13-27 weight portion, Flos daphnes odorae 12-22 weight portion, Folium Ligustri Lucidi 14-24 weight portion, Rhizoma Coptidis 11-23 weight portion, Rhizoma Curcumae 12-24 weight portion, Rhizoma typhae 12-26 weight portion, Herba veronicae arvensis 14-26 weight portion, Herba balanophorae japonicae 13-27 weight portion, Radix Et Rhizoma Rhei 12-24 weight portion, Monema flavescens Walker 3-5 weight portion, Rhizoma et radix smilacis santis 12-24 weight portion, Herba Clematidis Glaucae 11-21 weight portion, Herba eryngii foetidi 14-28 weight portion and Herba Chamaerhodoris Erectae 12-22 weight portion.

3. the pharmaceutical composition being used for the treatment of chicken and getting mildewed in warm conditions according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Scutellariae 22 weight portion, Fructus Gardeniae 15 weight portion, Herba Dendrobii 14 weight portion, Fructus Aurantii 18 weight portion, Gypsum Fibrosum 24 weight portion, Medulla Tetrapanacis 12 weight portion, Caulis Bambusae In Taenia 15 weight portion, Flos Lonicerae 21 weight portion, the Rhizoma Anemarrhenae 25 weight portion, Radix Ophiopogonis 12 weight portion, Cortex Phellodendri 18 weight portion, Herba Commelinae 22 weight portion, Herba Bulbophylli Odoratissim 30 weight portion, Plumula Nelumbinis 26 weight portion, Radix Glycyrrhizae 17 weight portion, Flos daphnes odorae 14 weight portion, the Folium Ligustri Lucidi 22 weight portion, Rhizoma Coptidis 21 weight portion, Rhizoma Curcumae 12 weight portion, Rhizoma typhae 16 weight portion, Herba veronicae arvensis 24 weight portion, Herba balanophorae japonicae 25 weight portion, Radix Et Rhizoma Rhei 22 weight portion, Monema flavescens Walker 3 weight portion, Rhizoma et radix smilacis santis 14 weight portion, Herba Clematidis Glaucae 18 weight portion, Herba eryngii foetidi 24 weight portion and Herba Chamaerhodoris Erectae 16 weight portion.

4. according to any one of claim 1-3, be used for the treatment of the pharmaceutical composition that chicken gets mildewed in warm conditions, it is characterized in that, described pharmaceutical composition also comprises Carapax Trionycis, Indigo Naturalis, Radix Trichosanthis, Rhizoma Polygonati Odorati and Nidus Vespae.

5. according to any one of claim 1-4, be used for the treatment of the pharmaceutical composition that chicken gets mildewed in warm conditions, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Scutellariae 10-25 weight portion, Fructus Gardeniae 10-18 weight portion, Herba Dendrobii 12-22 weight portion, Fructus Aurantii 11-21 weight portion, Gypsum Fibrosum 12-24 weight portion, Medulla Tetrapanacis 10-20 weight portion, Caulis Bambusae In Taenia 13-26 weight portion, Flos Lonicerae 14-26 weight portion, Rhizoma Anemarrhenae 10-30 weight portion, Radix Ophiopogonis 11-21 weight portion, Cortex Phellodendri 12-22 weight portion, Herba Commelinae 14-24 weight portion, Herba Bulbophylli Odoratissim 15-35 weight portion, Plumula Nelumbinis 10-26 weight portion, Radix Glycyrrhizae 13-27 weight portion, Flos daphnes odorae 12-22 weight portion, Folium Ligustri Lucidi 14-24 weight portion, Rhizoma Coptidis 11-23 weight portion, Rhizoma Curcumae 12-24 weight portion, Rhizoma typhae 12-26 weight portion, Herba veronicae arvensis 14-26 weight portion, Herba balanophorae japonicae 13-27 weight portion, Radix Et Rhizoma Rhei 12-24 weight portion, Monema flavescens Walker 3-5 weight portion, Rhizoma et radix smilacis santis 12-24 weight portion, Herba Clematidis Glaucae 11-21 weight portion, Herba eryngii foetidi 14-28 weight portion, Herba Chamaerhodoris Erectae 12-22 weight portion, Carapax Trionycis 10-20 weight portion, Indigo Naturalis 11-22 weight portion, Radix Trichosanthis 10-26 weight portion, Rhizoma Polygonati Odorati 14-28 weight portion and Nidus Vespae 10-18 weight portion.

6. according to any one of claim 1-5, be used for the treatment of the pharmaceutical composition that chicken gets mildewed in warm conditions, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Scutellariae 22 weight portion, Fructus Gardeniae 16 weight portion, Herba Dendrobii 14 weight portion, Fructus Aurantii 20 weight portion, Gypsum Fibrosum 22 weight portion, Medulla Tetrapanacis 10 weight portion, Caulis Bambusae In Taenia 24 weight portion, Flos Lonicerae 20 weight portion, the Rhizoma Anemarrhenae 30 weight portion, Radix Ophiopogonis 11 weight portion, Cortex Phellodendri 16 weight portion, Herba Commelinae 22 weight portion, Herba Bulbophylli Odoratissim 32 weight portion, Plumula Nelumbinis 24 weight portion, Radix Glycyrrhizae 25 weight portion, Flos daphnes odorae 14 weight portion, the Folium Ligustri Lucidi 24 weight portion, Rhizoma Coptidis 16 weight portion, Rhizoma Curcumae 22 weight portion, Rhizoma typhae 26 weight portion, Herba veronicae arvensis 20 weight portion, Herba balanophorae japonicae 27 weight portion, Radix Et Rhizoma Rhei 14 weight portion, Monema flavescens Walker 3 weight portion, Rhizoma et radix smilacis santis 16 weight portion, Herba Clematidis Glaucae 21 weight portion, Herba eryngii foetidi 28 weight portion, Herba Chamaerhodoris Erectae 20 weight portion, Carapax Trionycis 15 weight portion, Indigo Naturalis 14 weight portion, Radix Trichosanthis 26 weight portion, Rhizoma Polygonati Odorati 28 weight portion and Nidus Vespae 14 weight portion.

7. according to any one of claim 1-6, be used for the treatment of the pharmaceutical composition that chicken gets mildewed in warm conditions, it is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

8. according to any one of claim 1-6, be used for the treatment of the pharmaceutical composition that chicken gets mildewed in warm conditions, it is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

9. the preparation method being used for the treatment of the pharmaceutical composition that chicken is got mildewed in warm conditions as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

10. the preparation method being used for the treatment of the pharmaceutical composition that chicken is got mildewed in warm conditions as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps: