CN104225504A - Traditional Chinese medicine unguent for treating diabetic foot gangrene and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine unguent for treating diabetic foot gangrene and a preparation method thereof. The unguent includes the following raw materials by weight: 15-30 parts of atractylodes, 15-30 parts of immature bitter orange, 15-30 parts of angelica sinensis, 15-30 parts of tangerine peel, 15-30 parts of turtle shell, 15-30 parts of locust tree twigs, 12-25 parts of fructus aurantii, 12-25 parts of clematis root, 12-25 parts of trigone, 12-25 parts of curcuma zedoary, 12-25 parts of trogopterus dung, 12-25 parts of codonopsis pilosula, 9-20 parts of rhubarb, 9-20 parts of corydalis tuber, 9-20 parts of hedgehog hide, 6-15 parts of croton, 9-20 parts of ferula asafetida, 0.5-1 part of mush, 0.5-1 part of sal ammoniac, 400-500 parts of yellow lead and 1000 parts of sesame oil. The unguent has the advantages of being high in cure rate, small in dose, quick in effect, low in cost and simple in use. A user does not need to have injection or take medicine and does not need to be hospitalized, so that the unguent is favorable for popularization.

Description

Chinese medicine ointment for the treatment of diabetic foot gangrene and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine ointment, be specifically related to one and treat diabetic foot gangrene, and various cureless pernicious skin infection, decubital ulcer external traditional Chinese medicine ointment and preparation method thereof.

Background technology

Diabetic foot gangrene refers to that diabetics infects ulcer and deep tissue destruction due to the lower limb that merging neuropathy and various peripheral vessel pathological changes in various degree cause, and is mainly in middle-aged and elderly people.Gangrene is more common in lower limb, and the diabetics of 15% there will be above-mentioned ulcer, occurs 45% therefore amputation in the diabetics of above-mentioned ulcer.

The domestic treatment for diabetic foot gangrene at present, be generally the method using oral medicine, transfusion etc. traditional, treatment cost is high, weak effect, is difficult to cure.

Summary of the invention

What the present invention proposed is a kind ofly treat Chinese medicine ointment of diabetic foot gangrene and preparation method thereof, its object is intended to make to penetrate subcutaneous medicine and goes directly focus, set up new flesh, regeneration blood circulation, focus is progressively disappeared, effectively treatment diabetic foot gangrene and cureless pernicious skin infection, decubital ulcer.

Technical solution of the present invention: the Chinese medicine ointment for the treatment of diabetic foot gangrene, it is characterized in that raw material meter weight portion comprises: Rhizoma Atractylodis Macrocephalae 15-30 part, Fructus Aurantii Immaturus 15-30 part, Radix Angelicae Sinensis 15-30 part, Pericarpium Citri Reticulatae 15-30 part, Carapax Trionycis 15-30 part, Ramulus sophorae 15-30 part, Fructus Aurantii 12-25 part, Radix Clematidis 12-25 part, Rhizoma Sparganii 12-25 part, Rhizoma Curcumae 12-25 part, Oletum Trogopterori 12-25 part, Radix Codonopsis 12-25 part, Radix Et Rhizoma Rhei 9-20 part, Rhizoma Corydalis 9-20 part, Corium Erinacei Seu Hemiechianus 9-20 part, Fructus Crotonis 6-15 part, Resina Ferulae 9-20 part, Moschus 0.5-1 part, Sal Ammoniacus 0.5-1 part, Plumbum preparatium 400-500 part, Oleum sesami 1000 parts.

Its preparation method, comprises the following steps:

1) with parts by weight, get raw material, Rhizoma Atractylodis Macrocephalae 15-30 part, Fructus Aurantii Immaturus 15-30 part, Radix Angelicae Sinensis 15-30 part, Pericarpium Citri Reticulatae 15-30 part, Carapax Trionycis 15-30 part, Ramulus sophorae 15-30 part, Fructus Aurantii 12-25 part, Radix Clematidis 12-25 part, Rhizoma Sparganii 12-25 part, Rhizoma Curcumae 12-25 part, Oletum Trogopterori 12-25 part, Radix Codonopsis 12-25 part, Radix Et Rhizoma Rhei 9-20 part, Rhizoma Corydalis 9-20 part, Corium Erinacei Seu Hemiechianus 9-20 part, Fructus Crotonis 6-15 part;

2) by after the raw material mix homogeneously in step 1), by weight, put into Oleum sesami 1000 parts, soak 3-5 days, obtain mixed liquor;

3) by step 2) obtain mixed liquor heating reach 80-100 DEG C, decocts after 3-5 hour, is cooled to 30-40 DEG C, filtration obtain medicinal liquid;

4) medicine liquid heating obtained in step 3) is kept 80-100 DEG C, by weight, join in medicinal liquid by Resina Ferulae 9-20 part, Moschus 0.5-1 part, Sal Ammoniacus 0.5-1 part, Plumbum preparatium 400-500 part, constant temperature stirs;

5) dipped by the medicinal liquid ear of maize in step 4), instillation fills in the container of normal-temperature water, when medicinal liquid forms pearl from container bottom floating to the water surface, then stops stirring, and is cooled to 50-60 DEG C and obtains ointment;

6) be spread out in by ointment on the paper varied in size, natural cooling dries at normal temperatures, the Chinese medicine ointment of the diabetic foot gangrene that obtains medical treatment, and packaging, during use, is heated to 35-45 DEG C.

Advantage of the present invention: adopt rational formula proportioning, external is affixed on affected part, and Transdermal absorption therapy is gone directly focus, sets up new flesh regeneration blood circulation, cure rate is high, makes much to face the diabetics of amputation and various cureless pernicious skin infection, the patient of decubital ulcer gets well; Dose is few, instant effect, and expense is low, need not have an injection and take medicine, and use simple, patient need not be in hospital, and is beneficial to popularization.

Detailed description of the invention

Treat a Chinese medicine ointment for diabetic foot gangrene, its raw material comprises with parts by weight: Rhizoma Atractylodis Macrocephalae 15-30 part, Fructus Aurantii Immaturus 15-30 part, Radix Angelicae Sinensis 15-30 part, Pericarpium Citri Reticulatae 15-30 part, Carapax Trionycis 15-30 part, Ramulus sophorae 15-30 part, Fructus Aurantii 12-25 part, Radix Clematidis 12-25 part, Rhizoma Sparganii 12-25 part, Rhizoma Curcumae 12-25 part, Oletum Trogopterori 12-25 part, Radix Codonopsis 12-25 part, Radix Et Rhizoma Rhei 9-20 part, Rhizoma Corydalis 9-20 part, Corium Erinacei Seu Hemiechianus 9-20 part, Fructus Crotonis 6-15 part, Resina Ferulae 9-20 part, Moschus 0.5-1 part, Sal Ammoniacus 0.5-1 part, Plumbum preparatium 400-500 part, Oleum sesami 1000 parts.

The preparation method of the Chinese medicine ointment for the treatment of diabetic foot gangrene, comprises the following steps:

1) with parts by weight, get raw material, Rhizoma Atractylodis Macrocephalae 15-30 part, Fructus Aurantii Immaturus 15-30 part, Radix Angelicae Sinensis 15-30 part, Pericarpium Citri Reticulatae 15-30 part, Carapax Trionycis 15-30 part, Ramulus sophorae 15-30 part, Fructus Aurantii 12-25 part, Radix Clematidis 12-25 part, Rhizoma Sparganii 12-25 part, Rhizoma Curcumae 12-25 part, Oletum Trogopterori 12-25 part, Radix Codonopsis 12-25 part, Radix Et Rhizoma Rhei 9-20 part, Rhizoma Corydalis 9-20 part, Corium Erinacei Seu Hemiechianus 9-20 part, Fructus Crotonis 6-15 part;

2) by after the raw material mix homogeneously in step 1, with parts by weight, put into Oleum sesami 1000 parts, soak 3-5 days, obtain mixed liquor;

3) by step 2) obtain mixed liquor heating reach 80-100 DEG C, decocts after 3-5 hour, is cooled to 30-40 DEG C, filtration obtain medicinal liquid;

4) medicine liquid heating obtained in step 3) is kept 80-100 DEG C, by weight, join in medicinal liquid by Resina Ferulae 9-20 part, Moschus 0.5-1 part, Sal Ammoniacus 0.5-1 part, Plumbum preparatium 400-500 part, constant temperature stirs;

5) dipped by the medicinal liquid ear of maize in step 4), instillation fills in the container of normal-temperature water, when medicinal liquid forms pearl from container bottom floating to the water surface, then stops stirring, and is cooled to 50-60 DEG C and obtains ointment;

6) be spread out in by ointment on the paper varied in size, natural cooling dries at normal temperatures, the Chinese medicine ointment of the diabetic foot gangrene that obtains medical treatment, packaging.

During use, according to the size of patient wound, taken out by packaged ointment and be heated to 35-45 DEG C, be applied on patient wound, every 1-2 day is changed, until Wound healing.

Pharmacology analysis

The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness, diuretic, hidroschesis, cures mainly insufficiency of the spleen, lack of appetite, phlegm retention, vertigo and palpitation, edema.

Fructus Aurantii Immaturus: dispelling the stagnated QI, the famine that disappears, reduce phlegm, except painful abdominal mass, cure mainly stagnant in stop, feeling of fullness distending pain, constipation.

Radix Angelicae Sinensis: enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, cures mainly that lump in the abdomen knot is poly-, numbness of the skin, cellulitis skin infection, falls and mend damage.

Pericarpium Citri Reticulatae: regulate the flow of vital energy, spleen invigorating, in tune, dampness, to reduce phlegm, cure mainly incoordination between the spleen and stomach, fullness in the epigastrium and chest, lack of appetite, vomiting and diarrhoea, cough with copious phlegm.

Carapax Trionycis: YIN nourishing, YANG hyperactivity suppressing, hard masses softening and resolving, bring down a fever except steaming, closes for the deficiency of YIN, heating, consumptive fever, hectic fever due to YIN-deficiency, wind syndrome caused by deficiency, interior influencing meridian, abdominal mass chronic malaria malaria.

Ramulus sophorae: twig, bitter in the mouth, property are put down, and function hemostasis, pain relieving, elimination skin ulcer are itched, and cure mainly metrorrhagia dysentery, hemorrhoid complicated by anal fistula scabies, conjunctival congestion and swelling pain, skin pruritus.

Fructus Aurantii: dispelling the stagnated QI transforming phlegm and dispersing accumulations, cures mainly that chest and diaphragm, expectorant are stagnant, the feeling of stuffiness in chest, eructation, vomiting.

Radix Clematidis: cure mainly atmosphere of news service, dehumidifying, promoting blood circulation to remove obstruction in the collateral, detoxicating and resolving stagnation of pathogens.

Rhizoma Sparganii: removing blood stasis, circulation of qi promoting, removing food stagnancy pain relieving, cures mainly lump in the abdomen mass in the abdomen, congestion, amenorrhea, food stagnation distending pain.

Rhizoma Curcumae: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, cure mainly traumatic injury, congestion swells and ache.

Oletum Trogopterori: invigorate blood circulation, blood stasis dispelling, parch to black hemostasis.

Radix Codonopsis: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, cures mainly deficiency of the spleen and lung, the motive of breathing hard.

Radix Et Rhizoma Rhei: change stagnant, i.e. spleen lung benefiting pathogenic fire purging society silt removing toxic substances, cure mainly lump in the abdomen and tie poly-, pyretic toxicity pain infections.

Rhizoma Corydalis: invigorate blood circulation, regulate the flow of vital energy, pain relieving, cures mainly the pain that disappears of qi depression to blood stasis.

Corium Erinacei Seu Hemiechianus: blood-activating analgetic, astringing to arrest bleeding.

Fructus Crotonis: cure mainly malignant boil scabies, nevus verrucosus.

Resina Ferulae: removing food stagnancy falls apart painful abdominal mass, cures mainly congestion lump in the abdomen, mass in abdomen.

Moschus: refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, pain relieving dissipating blood stasis, cure mainly trusted subordinate's sudden pain, traumatic injury, sterilization.

Sal Ammoniacus: passive softening the hard mass, broken silt eliminating stagnation, cures mainly polyp order, lump in the abdomen knot gathers, treats the swollen malignant boil of skin ulcer pain.

Plumbum preparatium: removing toxic substances and promoting tissue regeneration, kill virus antipruritic, treatment of ulcer festers, skin eczema.

Embodiment 1

By weight, the Rhizoma Atractylodis Macrocephalae 15 parts, Fructus Aurantii Immaturus 15 parts, Radix Angelicae Sinensis 15 parts, Pericarpium Citri Reticulatae 15 parts, Carapax Trionycis 15 parts, Ramulus sophorae 15 parts, Fructus Aurantii 12 parts, Radix Clematidis 12 parts, Rhizoma Sparganii 12 parts, Rhizoma Curcumae 12 parts, Oletum Trogopterori 12 parts, Radix Codonopsis 12 parts, 9 parts, Radix Et Rhizoma Rhei, Rhizoma Corydalis 9 parts, Corium Erinacei Seu Hemiechianus 9 parts, Fructus Crotonis 6 parts will be comprised, after above-mentioned raw materials mixing, put into Oleum sesami 1000 parts to soak 3 days, obtain mixed liquor;

Mixed liquor heating is reached 80 DEG C, decocts after 3 hours, be cooled to 30 DEG C, filter medicinal residues and obtain medicinal liquid;

Above-mentioned medicine liquid heating is kept 80 DEG C, by weight, joins in medicinal liquid by Resina Ferulae 9 parts, 0.5 part, Moschus, Sal Ammoniacus 0.5 part, Plumbum preparatium 400 parts, constant temperature stirs;

Medicinal liquid ear of maize in being stirred by constant temperature dips, instillation fills in the container of normal-temperature water, if medicinal liquid forms pearl by container bottom floating to the water surface, namely stop heating and stir, be cooled to 50-60 DEG C and obtain ointment, be spread out in by ointment on the paper varied in size, room temperature natural cooling dries, the Chinese medicine ointment of the diabetic foot gangrene that obtains medical treatment, packaging.

Embodiment 2

By weight, by comprise the Rhizoma Atractylodis Macrocephalae 25 parts, Fructus Aurantii Immaturus 25 parts, Radix Angelicae Sinensis 25 parts, Pericarpium Citri Reticulatae 25 parts, Carapax Trionycis 25 parts, Ramulus sophorae 25 parts, Fructus Aurantii 20 parts, Radix Clematidis 20 parts, Rhizoma Sparganii 20 parts, Rhizoma Curcumae 20 parts, Oletum Trogopterori 20 parts, Radix Codonopsis 20 parts, 15 parts, Radix Et Rhizoma Rhei, Rhizoma Corydalis 15 parts, Corium Erinacei Seu Hemiechianus 15 parts, Fructus Crotonis 6 parts raw material mixing after, put into Oleum sesami 1000 parts to soak 4 days, obtain mixed liquor;

Mixed liquor heating is reached 90 DEG C, decocts after 4 hours, be cooled to 35 DEG C, filter medicinal residues and obtain medicinal liquid;

Above-mentioned medicine liquid heating is kept 90 DEG C, by weight, joins in medicinal liquid by Resina Ferulae 15 parts, 0.7 part, Moschus, Sal Ammoniacus 0.7 part, Plumbum preparatium 450 parts, constant temperature stirs;

Medicinal liquid ear of maize in being stirred by constant temperature dips, instillation fills in the container of normal-temperature water, if medicinal liquid forms pearl by container bottom floating to the water surface, namely stop heating and stir, be cooled to 50-60 DEG C and obtain ointment, be spread out in by ointment on the paper varied in size, room temperature natural cooling dries, the Chinese medicine ointment of the diabetic foot gangrene that obtains medical treatment, packaging.

Embodiment 3

By weight, by comprise the Rhizoma Atractylodis Macrocephalae 30 parts, Fructus Aurantii Immaturus 30 parts, Radix Angelicae Sinensis 30 parts, Pericarpium Citri Reticulatae 30 parts, Carapax Trionycis 30 parts, Ramulus sophorae 30 parts, Fructus Aurantii 25 parts, Radix Clematidis 25 parts, Rhizoma Sparganii 25 parts, Rhizoma Curcumae 25 parts, Oletum Trogopterori 25 parts, Radix Codonopsis 25 parts, 20 parts, Radix Et Rhizoma Rhei, Rhizoma Corydalis 20 parts, Corium Erinacei Seu Hemiechianus 20 parts, Fructus Crotonis 15 parts raw material mixing after, put into Oleum sesami 1000 parts to soak 5 days, obtain mixed liquor;

Mixed liquor heating is reached 100 DEG C, decocts after 5 hours, be cooled to 40 DEG C, filter medicinal residues and obtain medicinal liquid;

Above-mentioned medicine liquid heating is kept 100 DEG C, by weight, joins in medicinal liquid by Resina Ferulae 20 parts, 1 part, Moschus, Sal Ammoniacus 1 part, Plumbum preparatium 500 parts, constant temperature stirs;

Medicinal liquid ear of maize in being stirred by constant temperature dips, instillation fills in the container of normal-temperature water, if medicinal liquid forms pearl by container bottom floating to the water surface, namely stop heating and stir, be cooled to 50-60 DEG C and obtain ointment, be spread out in by ointment on the paper varied in size, room temperature natural cooling dries, the Chinese medicine ointment of the diabetic foot gangrene that obtains medical treatment, packaging.

The present invention, through the treatment to 100 patients, proves that medication is few, instant effect, expense are low, without the need to having an injection, taking medicine, avoids amputation, have good promotional value, enumerate model case below:

Case 1

Niu Yueying, female 69 years old, through Shang Tang town, Concord Hospital is diagnosed as diabetic foot gangrene, difficulty in walking lower limb thumb festers, once in the treatment of Sihong the People's Hospital, without positive effect, and cannot effect a radical cure, consultation of doctors suggestion amputation, accepts treatment in May, 2014 to my family, uses ointment of the present invention, be affixed on affected part outward, treat 10 days, lower limb left foot swells and ache disappearance, rehabilitation in 0 17 days in 2 months.

Case 2

Huang Qunzhen, female 44 years old, waist suffers from malignant boil, every day suppurates, ill 2 years 01 months, once at new district, Wuxi hospital surgical, but cannot effect a radical cure, without positive effect, treat in upon somebody's introduction in 2011 to my family, use ointment of the present invention to be affixed on affected part, within 2 days, once change, treat 10 days puss to discharge, within one month, pain disappears substantially, rehabilitation in 23 days February.

Case 3

Li Shaoguang, man 63 years old, is diagnosed as diabetic foot gangrene (sole has blister) through Nanjing drum tower hospital, treats in upon somebody's introduction in 2011 to my family, use ointment of the present invention to be affixed on affected part, and within 10 days, foot's edema disappears, and within 1 month 0 10 days, returns to one's perfect health.

Case 4

Wang Fang, female 40 years old, lie in bed 13 years, left buttocks festers and suppurates 1 year more than, is diagnosed as decubital ulcer, once treated in Bengbu First People's Hospital, all without positive effect, treat in my family upon somebody's introduction, use ointment of the present invention, treat pus discharge, swelling in 20 days to disappear, treat and return to one's perfect health for 2 months 0 10 days.

Case 5

Fu Jihua, man 66 years old, diabetes medical history 10 years, right crus of diaphragm swelling and little finger fester 50%, diabetic foot gangrene is diagnosed as, through expert consultation suggestion amputation, upon somebody's introduction on May 7th, 2014 in my family through Sixian County the People's Hospital, use ointment of the present invention swelling in 10 days to disappear, within 3 months, return to one's perfect health.

Claims (2)

1. treat the Chinese medicine ointment of diabetic foot gangrene, it is characterized in that raw material comprises with parts by weight: Rhizoma Atractylodis Macrocephalae 15-30 part, Fructus Aurantii Immaturus 15-30 part, Radix Angelicae Sinensis 15-30 part, Pericarpium Citri Reticulatae 15-30 part, Carapax Trionycis 15-30 part, Ramulus sophorae 15-30 part, Fructus Aurantii 12-25 part, Radix Clematidis 12-25 part, Rhizoma Sparganii 12-25 part, Rhizoma Curcumae 12-25 part, Oletum Trogopterori 12-25 part, Radix Codonopsis 12-25 part, Radix Et Rhizoma Rhei 9-20 part, Rhizoma Corydalis 9-20 part, Corium Erinacei Seu Hemiechianus 9-20 part, Fructus Crotonis 6-15 part, Resina Ferulae 9-20 part, Moschus 0.5-1 part, Sal Ammoniacus 0.5-1 part, Plumbum preparatium 400-500 part, Oleum sesami 1000 parts.

2. the preparation method of the Chinese medicine ointment for the treatment of diabetic foot gangrene as claimed in claim 1, is characterized in that the method comprises the following steps:

1) with parts by weight, get raw material, Rhizoma Atractylodis Macrocephalae 15-30 part, Fructus Aurantii Immaturus 15-30 part, Radix Angelicae Sinensis 15-30 part, Pericarpium Citri Reticulatae 15-30 part, Carapax Trionycis 15-30 part, Ramulus sophorae 15-30 part, Fructus Aurantii 12-25 part, Radix Clematidis 12-25 part, Rhizoma Sparganii 12-25 part, Rhizoma Curcumae 12-25 part, Oletum Trogopterori 12-25 part, Radix Codonopsis 12-25 part, Radix Et Rhizoma Rhei 9-20 part, Rhizoma Corydalis 9-20 part, Corium Erinacei Seu Hemiechianus 9-20 part, Fructus Crotonis 6-15 part;

2) by after the raw material mix homogeneously in step 1), by weight, put into Oleum sesami 1000 parts, soak 3-5 days, obtain mixed liquor;

3) by step 2) obtain mixed liquor heating reach 80-100 DEG C, decocts after 3-5 hour, is cooled to 30-40 DEG C, filtration obtain medicinal liquid;

4) medicine liquid heating obtained in step 3) is kept 80-100 DEG C, by weight, join in medicinal liquid by Resina Ferulae 9-20 part, Moschus 0.5-1 part, Sal Ammoniacus 0.5-1 part, Plumbum preparatium 400-500 part, constant temperature stirs;

5) dipped by the medicinal liquid ear of maize in step 4), instillation fills in the container of normal-temperature water, when medicinal liquid forms pearl from container bottom floating to the water surface, then stops stirring, and is cooled to 50-60 DEG C and obtains ointment;

6) be spread out in by ointment on the paper varied in size, natural cooling dries at normal temperatures, the Chinese medicine ointment of the diabetic foot gangrene that obtains medical treatment, and packaging, during use, is heated to 35-45 DEG C.