CN110339325A - A kind of exterior-applied medical wine and preparation method thereof for treating rheumatism - Google Patents
A kind of exterior-applied medical wine and preparation method thereof for treating rheumatism Download PDFInfo
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- CN110339325A CN110339325A CN201910784998.1A CN201910784998A CN110339325A CN 110339325 A CN110339325 A CN 110339325A CN 201910784998 A CN201910784998 A CN 201910784998A CN 110339325 A CN110339325 A CN 110339325A
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
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Abstract
The embodiment of the invention discloses a kind of exterior-applied medical wines and preparation method thereof for treating rheumatism, belong to pharmaceutical technology field.The exterior-applied medical wine of the treatment rheumatism is prepared from the following raw materials: Chinese prickly ash, Rosa roxburghii Tratt tree root, iron Chinese lute root, agkistrodon, Cortex Eucommiae, ground bettle, polygonum cuspidate, turmeric, paniculate swallowwort, Rhizoma Chuanxiong, Wang Ling rouge, olibanum, myrrh, teasel root, parasitism, radix achyranthis bidentatae, the stem pith of the rice-paper plant, the rhizome of davallia, rhizoma cibotii, gentianae macrophyllae, Rhizoma Gastrodiae, ramulus cinnamomi, the root of fangji, the root of Chinese clematis, pawpaw, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, dragon's blood, monkshood, cortex acanthopanacis, asarum, resina liquidamberis, borneol, alcohol.All medicines share plays the role of activating microcirculation and removing stasis medicinal, Dredging collaterals to dissipate cold, detoxification swelling and pain relieving, and treatment rheumatism is had a good effect.Exterior-applied medical wine of the invention to no skin irritation, it is highly-safe and to body without obvious toxic-side effects, have broad application prospects.
Description
Technical field
The present embodiments relate to pharmaceutical technology fields, and in particular to a kind of exterior-applied medical wine for treating rheumatism and its preparation side
Method.
Background technique
The resistance of numbness, i.e. numbness is obstructed.Rheumatism refers to human body machine table, channels and collaterals because closing caused by experiencing wind, cold, wet, heat etc. with limbs
Section and DOMS numbness, weigh, joint stuffiness, even the scorching hot a kind of disease waited as primary symptom of arthrocele, site of pathological change master
It will be at positions such as neck, shoulder, waist, joints.Its pathogenesis system human righteousness is impaired, stasis blocking train of thought, qi depression to blood stasis, functional activity of QI being not smooth institute
It causes, the especially change of modern society people living habit, the quickening of work rhythm, the increase of various pressure, local is chronic
Strain is the factor for leading to morbidity.
Currently, mainly including physiotherapies and the drug therapies such as massage acupuncture pricking and cupping for treating rheumatism.Physics is controlled
Therapy specific aim is poor, generally reflects that therapeutic effect is bad.Drug therapy includes medicine for oral administration and externally applied drug two major classes, medicine for oral administration pair
Act on it is larger, long-term use have certain harm to body；Externally applied drug is mainly patch and liniment, and existing externally applied drug is in reality
Therapeutic effect defect ideal not to the utmost is equally existed in use, is increased the pain and worry of patient, is reduced the life of patient
Quality.
Therefore, development & production goes out one kind exterior-applied medical wine for treating rheumatism curative for effect and has great significance.Have
In consideration of it, the present invention is specifically proposed.
Summary of the invention
For this purpose, the embodiment of the present invention provides a kind of exterior-applied medical wine and preparation method thereof for treating rheumatism, it is existing outer to solve
The problem ideal not to the utmost of therapeutic effect existing for medication.
To achieve the goals above, the embodiment of the present invention provides the following technical solutions:
According to a first aspect of the embodiments of the present invention, the embodiment of the invention provides a kind of exterior-applied medical wine for treating rheumatism,
It is prepared from the following raw materials in parts by weight: 750-800 parts of Chinese prickly ash, 400-450 parts of Rosa roxburghii Tratt tree root, 400-450 parts of iron Chinese lute root, white
Snake 200-240 parts of flower, 300-350 parts of Cortex Eucommiae, 300-350 parts of ground bettle, 300-350 parts of polygonum cuspidate, 300-350 parts of turmeric, Xu are long
300-350 parts of minister in ancient times, 300-350 parts of Rhizoma Chuanxiong, 300-350 parts of Wang Ling rouge, 300-350 parts of olibanum, 300-350 parts of myrrh, teasel root
300-350 parts, 300-350 parts of parasitism, 300-350 parts of radix achyranthis bidentatae, 300-350 parts of the stem pith of the rice-paper plant, 300-350 parts of the rhizome of davallia, rhizoma cibotii 300-
350 parts, 300-350 parts of gentianae macrophyllae, 300-350 parts of Rhizoma Gastrodiae, 300-350 parts of ramulus cinnamomi, 300-350 parts of the root of fangji, root of Chinese clematis 300-350
Part, 300-350 parts of pawpaw, 300-350 parts of Radix Angelicae Pubescentis, 300-350 parts of Rhizoma Et Radix Notopterygii, 300-350 parts of Caulis Spatholobi, 200-220 parts of dragon's blood, river
200-220 parts black, 200-220 parts of cortex acanthopanacis, 200-220 parts of asarum, 400-450 parts of resina liquidamberis, 150-180 parts of borneol, alcohol
10000 parts.
Further, it is prepared from the following raw materials in parts by weight: 750 parts of Chinese prickly ash, 400 parts of Rosa roxburghii Tratt tree root, iron Chinese lute root 400
Part, 220 parts of agkistrodon, 300 parts of Cortex Eucommiae, 300 parts of ground bettle, 300 parts of polygonum cuspidate, 300 parts of turmeric, 300 parts of paniculate swallowwort, Rhizoma Chuanxiong 300
Part, 300 parts of Wang Ling rouge, 300 parts of olibanum, 300 parts of myrrh, 300 parts of teasel root, parasitic 300 parts, 300 parts of radix achyranthis bidentatae, 300 parts of the stem pith of the rice-paper plant, bone
Broken benefit 300 parts, 300 parts of rhizoma cibotii, 300 parts of gentianae macrophyllae, 300 parts of Rhizoma Gastrodiae, 300 parts of ramulus cinnamomi, 300 parts of the root of fangji, 300 parts of the root of Chinese clematis, pawpaw
300 parts, 300 parts of Radix Angelicae Pubescentis, 300 parts of Rhizoma Et Radix Notopterygii, 300 parts of Caulis Spatholobi, 200 parts of dragon's blood, 200 parts of monkshood, 200 parts of cortex acanthopanacis, asarum 200
Part, 400 parts of resina liquidamberis, 150 parts of borneol, 10000 parts of alcohol.
Further, the concentration of the alcohol is 75%.
Further, the rheumatism include cervical spondylosis, it is scapulohumeral periarthritis, pain in the loins, skelagia, rheumatic arthritis, numb limb, soft
Tissue damage, bruise, gout, new and old property bone fracture.
According to a second aspect of the embodiments of the present invention, the embodiment of the invention provides a kind of external applications of above-mentioned treatment rheumatism
The preparation method of liquid medicine, comprising the following steps:
(1) by Chinese prickly ash, Rosa roxburghii Tratt tree root, iron Chinese lute root, agkistrodon, Cortex Eucommiae, ground bettle, polygonum cuspidate, turmeric, paniculate swallowwort, Rhizoma Chuanxiong,
Wang Ling rouge, olibanum, myrrh, teasel root, parasitism, radix achyranthis bidentatae, the stem pith of the rice-paper plant, the rhizome of davallia, rhizoma cibotii, gentianae macrophyllae, Rhizoma Gastrodiae, ramulus cinnamomi, the root of fangji, the root of Chinese clematis,
Pawpaw, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, dragon's blood, monkshood, cortex acanthopanacis, asarum dry respectively is ground into smalls, by resina liquidamberis and borneol
It smashs into powder to pieces respectively, weighs each raw material by formula ratio；
(2) into the alcohol of 9000 parts by weight be added Chinese prickly ash, Rosa roxburghii Tratt tree root, iron Chinese lute root, agkistrodon, Cortex Eucommiae, ground bettle,
Polygonum cuspidate, turmeric, paniculate swallowwort, Rhizoma Chuanxiong, Wang Ling rouge, olibanum, myrrh, teasel root, parasitism, radix achyranthis bidentatae, the stem pith of the rice-paper plant, the rhizome of davallia, rhizoma cibotii, gentianae macrophyllae,
Rhizoma Gastrodiae, ramulus cinnamomi, the root of fangji, the root of Chinese clematis, pawpaw, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, dragon's blood, monkshood, cortex acanthopanacis, asarum, sealed soak 15-
20 days, filtering removed filter residue, obtains mixture A；
(3) resina liquidamberis and borneol are added into the alcohol of 1000 parts by weight, sealed soak 15-20 days, filtering removed filter
Slag obtains mixture B；
(4) the mixture A and mixture B is uniform.
Further, in the soaking process of step (2) and step (3), soak is stirred once, every time every 3 days
Mixing time 20-30 minutes.
The pharmacological property and effect of each raw material of the invention are as follows:
Chinese prickly ash: nature and flavor are pungent, warm, returns spleen, stomach, kidney channel.With the antipruritic effect of warm in pain, desinsection.For treating syncope due to pathogenic cold
The diseases such as abdominal pain, cold-dampness vomiting and diarrhoea, pruritus vulvae, eczema, abdominal pain due to enterositosis, deadly cold hand and foot, the unhappy vomiting of ascaris, toothache.This product also has part
The effect of anesthesia.
Rosa roxburghii Tratt tree root: for the root of rosaceous plant Rosa roxburghii Tratt, stomach invigorating helps digestion, antidiarrheal, arresting seminal emission.Cure mainly stomachache, diarrhea, dysentery,
Spermatorrhea, metrorrhagia and metrostaxis, leukorrhagia, chronic cough.
Iron hedge root: also making bird not stand, and is called vest thorn, and effect is dehumidifying, and traumatic injury, soft tissue bruise, Red Indian race is swollen
Bitterly.
Agkistrodon: sweet-salty, it is warm-natured；It is toxic；Enter liver, the spleen channel；With wind-damp dispelling, saturating muscles and bones, the effect of jerking of calming the frightened；It cures mainly
Rheumatism paralysis, arthralgia, leprosy, scabies leprosy, child convulsion are twitched, tetanus, syphilis, scrofula malignant sore.
Cortex Eucommiae: the i.e. dry bark of Eucommiaceae plant Cortex Eucommiae.Its is sweet in flavor, warm-natured.It tonifies the liver and kidney, strengthen muscles and bones, improve
The effect of punching times, strengthen meridian and miscarriage prevention.
Ground bettle: taste is salty, cold in nature；Return liver warp；With dissipating blood stasis with potent drugs, the effect of reunion of fractured tendons and bones.For traumatic injury, the injury of tendon and muscle
Fracture, blood stasis, postpartum stasis abdominal pain, addiction lump in the abdomen lump in the abdomen.
Polygonum cuspidate: it is slight bitter, slightly cold, return liver, gallbladder, lung channel.Have effects that promoting blood circulation, dissipate the stasis of blood, promoting menstruation, antibechic, is used for joint numbness
Bitterly, jaundice with damp-heat pathogen, menostasis, postpartum blood stasis do not Xia , wei lump in the abdomen, coughing with a lot of sputum, scald, traumatic injury, carbuncle sore tumefacting virus.
Turmeric: bitter, pungent；It is warm-natured.Returns spleen；Liver Channel.Energy promoting the circulation of qi broken stasis of blood, it is inducing meastruation to relieve menalgia.Cure mainly chest and abdomen swelling and pain, shoulder arm numbness
Bitterly, irregular menstruation, amenorrhoea, traumatic injury.
Paniculate swallowwort: acrid flavour, it is warm-natured.Return liver, stomach meridian.With wind-expelling pain-stopping, relieving itching and eliminating swelling and other effects.
Rhizoma Chuanxiong: acrid flavour, it is warm-natured.Return liver, gallbladder, pericardium channel.With blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.Cure mainly blood stasis gas
Stagnant pain card, headache, rheumatic arthralgia.
Wang Ling rouge: sweet, warm.Promoting blood circulation to remove blood stasis, fries charcoal hemostasis.For trusted subordinate's extravasated blood, dysmenorrhea, blood stasis, postpartum silt
Hemoperitoneum pain；Fry charcoal and control metrostaxis；Traumatic injury, snake, insect bite are controlled in external application.
Olibanum: pungent, bitter, temperature；Return heart, liver, the spleen channel.It is relieved pain with blood-activating and qi-promoting, the effect of detumescence and promoting granulation.Cure mainly promoting blood circulation row
Gas analgesic, detumescence and promoting granulation, qi depression to blood stasis pain.
Myrrh: acrid flavour, hardship, it is mild-natured.Return heart, liver, the spleen channel.With scattered stasis pain, detumescence and promoting granulation.For chest impediment and cardialgia, stomach
Gastral cavity pain, dysmenorrhea menostasis, postpartum stasis , abdominal mass and abdominal pain, rheumatic arthralgia, traumatic injury, the treatment of the illnesss such as carbuncle swells sore.
Teasel root: slightly warm in nature, it is bitter, pungent.Return liver warp, kidney channel.Nourishing liver and kidney, strengthening the bones and muscles, continuous injured, only metrorrhagia and metrostaxis.Belong to qi-restoratives medicine
The yang-tonifying drug of lower classification.
It is parasitic: alias: Chinese ilex, northern parasitism, Liu Jisheng, it is sudden it is careless, incline post, Huang Jisheng, Taiwan mistletoe.Bitter is mild-natured.
It is included into liver kidney channel.Nourishing liver and kidney, curing rheumatism, strengthening the bones and muscles, nourishing blood and preventing abortion.Cure mainly lumbocrural pain.Muscles and bones is powerless, movement of the foetus vaginal bleeding during pregnancy.
Radix achyranthis bidentatae: bitter, acid；It is mild-natured.Enter liver；Kidney channel.Nourishing liver and kidney；Strengthening the bones and muscles；Blood circulation；It ignites (blood) downlink；Diuresis
It is treating stranguria.Cure mainly soreness of waist and knee joint；Flaccidity and weakness of the lower limbs；Amenorrhea due to stagnation of blood；Dysmenorrhea；Postpartum abdominal pain due to blood stasis；Abdominal mass；Placenta retension；Heat gonorrhea；Blood
Leaching；Traumatic injury；Carbuncle swells dislikes sore；Abscess of throat.
The stem pith of the rice-paper plant: cold nature is sweet in flavor, light.Distributed in lung channel, stomach meridian.Reducing fever and causing diuresis, the lower cream of ventilation.Belong to damp-clearing drug subordinate point
The stranguria-relieving diuretic of class.
The rhizome of davallia: bitter in taste, temperature.Return kidney, Liver Channel.Major function The strong bone of kidney tonifying, continues and hinders pain relieving.For lumbago due to the kidney deficiency, ear
Ring is deaf, tooth mobility, falling winks frustrates, injured bone；Control outward alopecia areata, leucoderma.
Rhizoma cibotii: bitter in taste, sweet, warm.Return liver and kidney channel.Major function nourishing liver and kidney, strong spinal column, wind-damp dispelling.For waist and knee acid
It is soft, weakness of the lower extremities, rheumatic arthralgia.
Gentianae macrophyllae: it is pungent, bitter, it puts down.Return stomach, liver, gallbladder channel.Major function wind-damp dispelling, clearing away damp-heat, stopping numbness pain.For rheumatic arthralgia,
Muscle arteries and veins contraction, skeletal pain, afternoon tidal fever, infantile malnutrition generates heat.
Rhizoma Gastrodiae: acrid-sweet flavor, it is mild-natured.Return liver warp.Wind-dispelling, antispastic, blood pressure lowering, suppressing hyperactive liver for calming endogenous wind, it is calming the liver, remove obstruction in channels to relieve pain.
Ramulus cinnamomi: it is acrid flavour, sweet, it is warm-natured.Return bladder meridian, the heart channel of Hang-Shaoyin, lung channel.Relieving muscles diaphoresis, warming meridians and promoting circulation of qi, helps yang transforming qi, Ping Chong
Sending down abnormally ascending belongs to warm-pungent diaphoretic drug.
The root of fangji: it is bitter, it trembles with fear.Return bladder, lung channel.Major function inducing diuresis for removing edema, wind-expelling pain-stopping.For oedema tinea pedis, urine is not
Benefit, eczema sore, rheumatic arthralgia；Hypertension.
The root of Chinese clematis: pungent, salty, temperature.Return bladder meridian.Major function dispelling wind and eliminating dampness, removes obstruction in channels to relieve pain.For rheumatic arthralgia, limbs
Numbness, muscle arteries and veins contraction, joint stuffiness, bone are choked with sobs larynx.
Pawpaw: it is warm-natured, it is sour.Return liver warp, the spleen channel.Calming the liver relaxing muscles and tendons, stomach function regulating dampness elimination.Belong to the wind-dispelling of medicine for rheumatism subordinate classification
Wet strengthening the bones and muscles medicine.
Radix Angelicae Pubescentis: acrid flavour, hardship, slightly warm in nature.Return kidney, bladder meridian.Dispelling wind and eliminating dampness, arthritis analgesic.It is used for treating arthralgia due to cold and dampness, waist and knee pain
Bitterly, few the moon volt wind headache, headache caused by cold and dampness.
Rhizoma Et Radix Notopterygii: acrid flavour, hardship, it is warm-natured.Enter bladder, kidney channel.Relieving exterior syndrome and dispelling cold, expelling wind and eliminating dampness, analgesic.Cure mainly anemofrigid cold, wind
Cold-dampness numbness, item strengthening tendons are anxious, joint ache, geomantic omen edema, skin sore.
Caulis Spatholobi: it is warm-natured, it is bitter, sweet.Return liver warp, kidney channel.It enriches blood, invigorate blood circulation, dredging collateral.Belong to the work classified under drug for invigorating blood circulation and eliminating stasis
Blood emmenagogue.
Dragon's blood: it is mild-natured, it is sweet in flavor, salty.Thoughts of returning home warp, Liver Channel.Removing blood stasis and relieving pain, hemostasia and promoting granulation.Belong to the change of hemostatic subordinate classification
Stasis of blood hemostatic.
Monkshood: property heat, acrid flavour, hardship are very toxic.Thoughts of returning home warp, Liver Channel, kidney channel, the spleen channel.Dispelling wind and eliminating dampness, antalgic.Category is dispelled
The wind-damp-dispelling and cold-dissipating medicinal of medicine for rheumatism subordinate classification.
Cortex acanthopanacis: acrid flavour, hardship, it is warm-natured.Return liver and kidney channel.Wind-damp dispelling tonifies the liver and kidney, and strengthens muscles and bones, inducing diuresis for removing edema.For
Bi condition, muscles and bones impotence, children's retardation of walking, asthenia, oedema, tinea pedis.
Asarum: acrid in flavour and warm in nature.Return heart, lung, kidney channel.Expelling wind and clearing away cold, sensible analgesic, warming lung and resolving fluid.For anemofrigid cold, have a headache,
Toothache, nasosinusitis of having a stuffy nose, rheumatic arthralgia, sputum cough.
Resina liquidamberis: mild-natured, acrid flavour, slight bitter.Distributed in lung channel, the spleen channel.Promoting blood circulation and stopping pain, removing toxic substances, myogenic, cool blood.Belong to removing toxic substances and promoting tissue regeneration
Medicine.With controlling traumatic injury, ulcer sore pain, haematemesis, traumatic hemorrhage etc..
Borneol: it is pungent, bitter, it is slightly cold.Return heart, spleen, lung channel.Inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.It faints for pyreticosis coma, convulsion, apoplexy
Coma due to blocking of the respiratory system, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, hot eyes, aphtha, abscess of throat, purulent ear canal.
The embodiment of the present invention has the advantages that
The exterior-applied medical wine for the treatment of rheumatism of the invention, with Chinese prickly ash, Rosa roxburghii Tratt tree root, iron Chinese lute root, agkistrodon, Cortex Eucommiae, ground beetle
Worm, polygonum cuspidate, turmeric, paniculate swallowwort, Rhizoma Chuanxiong, Wang Ling rouge, olibanum, myrrh, teasel root, parasitism, radix achyranthis bidentatae, the stem pith of the rice-paper plant, the rhizome of davallia, rhizoma cibotii, the Qin
Macrophylla, Rhizoma Gastrodiae, ramulus cinnamomi, the root of fangji, the root of Chinese clematis, pawpaw, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, dragon's blood, monkshood, cortex acanthopanacis, asarum, resina liquidamberis,
Borneol is raw material, and all medicines share plays the role of activating microcirculation and removing stasis medicinal, Dredging collaterals to dissipate cold, detoxification swelling and pain relieving, includes cervical vertebra for treatment
Disease, scapulohumeral periarthritis, pain in the loins, skelagia, rheumatic arthritis, numb limb, soft tissue injury, bruise, gout, new and old property bone fracture
Rheumatism has a good effect.Exterior-applied medical wine of the invention is highly-safe and secondary without obvious poison to body to no skin irritation
Effect, has broad application prospects.
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book is understood other advantages and efficacy of the present invention easily, it is clear that described embodiment is the present invention one
Section Example, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not doing
Every other embodiment obtained under the premise of creative work out, shall fall within the protection scope of the present invention.
Embodiment 1
The preparation method of the exterior-applied medical wine of the treatment rheumatism of the present embodiment the following steps are included:
(1) by Chinese prickly ash, Rosa roxburghii Tratt tree root, iron Chinese lute root, agkistrodon, Cortex Eucommiae, ground bettle, polygonum cuspidate, turmeric, paniculate swallowwort, Rhizoma Chuanxiong,
Wang Ling rouge, olibanum, myrrh, teasel root, parasitism, radix achyranthis bidentatae, the stem pith of the rice-paper plant, the rhizome of davallia, rhizoma cibotii, gentianae macrophyllae, Rhizoma Gastrodiae, ramulus cinnamomi, the root of fangji, the root of Chinese clematis,
Pawpaw, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, dragon's blood, monkshood, cortex acanthopanacis, asarum dry respectively is ground into smalls, by resina liquidamberis and borneol
Smash into powder to pieces respectively；
(2) 400 parts and 150 parts of borneol of the addition resina liquidamberis into the alcohol of 1000 parts by weight, sealed soak 15 days, every 3
Soak is stirred primary, each mixing time 25 minutes by it, and filtering removes filter residue, obtains mixture A；
(3) 750 parts of Chinese prickly ash, 400 parts of Rosa roxburghii Tratt tree root, 400 parts of iron Chinese lute root, white flower are added into the alcohol of 9000 parts by weight
220 parts of snake, 300 parts of Cortex Eucommiae, 300 parts of ground bettle, 300 parts of polygonum cuspidate, 300 parts of turmeric, 300 parts of paniculate swallowwort, 300 parts of Rhizoma Chuanxiong, Wang Ling
300 parts of rouge, 300 parts of olibanum, 300 parts of myrrh, 300 parts of teasel root, parasitic 300 parts, 300 parts of radix achyranthis bidentatae, 300 parts of the stem pith of the rice-paper plant, the rhizome of davallia 300
Part, 300 parts of rhizoma cibotii, 300 parts of gentianae macrophyllae, 300 parts of Rhizoma Gastrodiae, 300 parts of ramulus cinnamomi, 300 parts of the root of fangji, 300 parts of the root of Chinese clematis, 300 parts of pawpaw, solely
300 parts, 300 parts of Rhizoma Et Radix Notopterygii, 300 parts of Caulis Spatholobi, 200 parts of dragon's blood, 200 parts of monkshood, 200 parts of cortex acanthopanacis, 200 parts of asarum living, sealing
It impregnates 15 days, soak is stirred to primary, each mixing time 25 minutes every 3 days, filtering removes filter residue, obtains mixture
B；
(4) mixture A and mixture B is uniform.
Embodiment 2
The preparation method of the exterior-applied medical wine of the treatment rheumatism of the present embodiment the following steps are included:
(1) by Chinese prickly ash, Rosa roxburghii Tratt tree root, iron Chinese lute root, agkistrodon, Cortex Eucommiae, ground bettle, polygonum cuspidate, turmeric, paniculate swallowwort, Rhizoma Chuanxiong,
Wang Ling rouge, olibanum, myrrh, teasel root, parasitism, radix achyranthis bidentatae, the stem pith of the rice-paper plant, the rhizome of davallia, rhizoma cibotii, gentianae macrophyllae, Rhizoma Gastrodiae, ramulus cinnamomi, the root of fangji, the root of Chinese clematis,
Pawpaw, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, dragon's blood, monkshood, cortex acanthopanacis, asarum dry respectively is ground into smalls, by resina liquidamberis and borneol
Smash into powder to pieces respectively；
(2) 420 parts and 180 parts of borneol of the addition resina liquidamberis into the alcohol of 1000 parts by weight, sealed soak 18 days, every 3
Soak is stirred primary, each mixing time 20 minutes by it, and filtering removes filter residue, obtains mixture A；
(3) 780 parts of Chinese prickly ash, 420 parts of Rosa roxburghii Tratt tree root, 450 parts of iron Chinese lute root, white flower are added into the alcohol of 9000 parts by weight
200 parts of snake, 300 parts of Cortex Eucommiae, 300 parts of ground bettle, 300 parts of polygonum cuspidate, 300 parts of turmeric, 350 parts of paniculate swallowwort, 350 parts of Rhizoma Chuanxiong, Wang Ling
350 parts of rouge, 350 parts of olibanum, 350 parts of myrrh, 330 parts of teasel root, parasitic 330 parts, 330 parts of radix achyranthis bidentatae, 330 parts of the stem pith of the rice-paper plant, the rhizome of davallia 300
Part, 300 parts of rhizoma cibotii, 350 parts of gentianae macrophyllae, 350 parts of Rhizoma Gastrodiae, 350 parts of ramulus cinnamomi, 300 parts of the root of fangji, 300 parts of the root of Chinese clematis, 300 parts of pawpaw, solely
300 parts, 330 parts of Rhizoma Et Radix Notopterygii, 330 parts of Caulis Spatholobi, 220 parts of dragon's blood, 210 parts of monkshood, 210 parts of cortex acanthopanacis, 210 parts of asarum living, sealing
It impregnates 18 days, soak is stirred to primary, each mixing time 20 minutes every 3 days, filtering removes filter residue, obtains mixture
B；
(4) mixture A and mixture B is uniform.
Embodiment 3
The preparation method of the exterior-applied medical wine of the treatment rheumatism of the present embodiment the following steps are included:
(1) by Chinese prickly ash, Rosa roxburghii Tratt tree root, iron Chinese lute root, agkistrodon, Cortex Eucommiae, ground bettle, polygonum cuspidate, turmeric, paniculate swallowwort, Rhizoma Chuanxiong,
Wang Ling rouge, olibanum, myrrh, teasel root, parasitism, radix achyranthis bidentatae, the stem pith of the rice-paper plant, the rhizome of davallia, rhizoma cibotii, gentianae macrophyllae, Rhizoma Gastrodiae, ramulus cinnamomi, the root of fangji, the root of Chinese clematis,
Pawpaw, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, dragon's blood, monkshood, cortex acanthopanacis, asarum dry respectively is ground into smalls, by resina liquidamberis and borneol
Smash into powder to pieces respectively, it is spare to weigh each medicinal material by formula ratio；
(2) 450 parts and 150 parts of borneol of the addition resina liquidamberis into the alcohol of 1000 parts by weight, sealed soak 15 days, every 3
Soak is stirred primary, each mixing time 30 minutes by it, and filtering removes filter residue, obtains mixture A；
(3) 750 parts of Chinese prickly ash, 450 parts of Rosa roxburghii Tratt tree root, 420 parts of iron Chinese lute root, white flower are added into the alcohol of 9000 parts by weight
220 parts of snake, 330 parts of Cortex Eucommiae, 330 parts of ground bettle, 330 parts of polygonum cuspidate, 330 parts of turmeric, 300 parts of paniculate swallowwort, 300 parts of Rhizoma Chuanxiong, Wang Ling
300 parts of rouge, 320 parts of olibanum, 320 parts of myrrh, 320 parts of teasel root, 310 parts parasitic, 300-350 parts of radix achyranthis bidentatae, 350 parts of the stem pith of the rice-paper plant, bone are broken
Mend 350 parts, 350 parts of rhizoma cibotii, 330 parts of gentianae macrophyllae, 330 parts of Rhizoma Gastrodiae, 300 parts of ramulus cinnamomi, 300 parts of the root of fangji, 350 parts of the root of Chinese clematis, pawpaw 330
Part, 300 parts of Radix Angelicae Pubescentis, 350 parts of Rhizoma Et Radix Notopterygii, 350 parts of Caulis Spatholobi, 220 parts of dragon's blood, 200 parts of monkshood, 200 parts of cortex acanthopanacis, 200 parts of asarum,
Sealed soak 15 days, soak is stirred to primary, each mixing time 30 minutes every 3 days, filtering removes filter residue, mixed
Close object B；
(4) mixture A and mixture B is uniform.
Embodiment 4
The preparation method of the exterior-applied medical wine of the treatment rheumatism of the present embodiment the following steps are included:
(1) by Chinese prickly ash, Rosa roxburghii Tratt tree root, iron Chinese lute root, agkistrodon, Cortex Eucommiae, ground bettle, polygonum cuspidate, turmeric, paniculate swallowwort, Rhizoma Chuanxiong,
Wang Ling rouge, olibanum, myrrh, teasel root, parasitism, radix achyranthis bidentatae, the stem pith of the rice-paper plant, the rhizome of davallia, rhizoma cibotii, gentianae macrophyllae, Rhizoma Gastrodiae, ramulus cinnamomi, the root of fangji, the root of Chinese clematis,
Pawpaw, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, dragon's blood, monkshood, cortex acanthopanacis, asarum dry respectively is ground into smalls, by resina liquidamberis and borneol
Smash into powder to pieces respectively；
(2) 400 parts and 160 parts of borneol of resina liquidamberis are added into the alcohol of 1000 parts by weight, sealed soak 20 days, filters,
Soak was stirred to primary, each mixing time 20 minutes every 3 days, removing filter residue obtains mixture A；
(3) 800 parts of Chinese prickly ash, 450 parts of Rosa roxburghii Tratt tree root, 450 parts of iron Chinese lute root, white flower are added into the alcohol of 9000 parts by weight
240 parts of snake, 350 parts of Cortex Eucommiae, 350 parts of ground bettle, 330 parts of polygonum cuspidate, 330 parts of turmeric, 350 parts of paniculate swallowwort, 320 parts of Rhizoma Chuanxiong, Wang Ling
350 parts of rouge, 300 parts of olibanum, 330 parts of myrrh, 330 parts of teasel root, parasitic 350 parts, 350 parts of radix achyranthis bidentatae, 340 parts of the stem pith of the rice-paper plant, the rhizome of davallia 320
Part, 310 parts of rhizoma cibotii, 300 parts of gentianae macrophyllae, 350 parts of Rhizoma Gastrodiae, 330 parts of ramulus cinnamomi, 320 parts of the root of fangji, 300 parts of the root of Chinese clematis, 350 parts of pawpaw, solely
320 parts, 320 parts of Rhizoma Et Radix Notopterygii, 340 parts of Caulis Spatholobi, 210 parts of dragon's blood, 220 parts of monkshood, 220 parts of cortex acanthopanacis, 210 parts of asarum living, sealing
It impregnates 15 days, soak is stirred to primary, each mixing time 30 minutes every 3 days, filtering removes filter residue, obtains mixture
B；
(4) mixture A and mixture B is uniform.
Embodiment 5
The preparation method of the exterior-applied medical wine of the treatment rheumatism of the present embodiment the following steps are included:
(1) by Chinese prickly ash, Rosa roxburghii Tratt tree root, iron Chinese lute root, agkistrodon, Cortex Eucommiae, ground bettle, polygonum cuspidate, turmeric, paniculate swallowwort, Rhizoma Chuanxiong,
Wang Ling rouge, olibanum, myrrh, teasel root, parasitism, radix achyranthis bidentatae, the stem pith of the rice-paper plant, the rhizome of davallia, rhizoma cibotii, gentianae macrophyllae, Rhizoma Gastrodiae, ramulus cinnamomi, the root of fangji, the root of Chinese clematis,
Pawpaw, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, dragon's blood, monkshood, cortex acanthopanacis, asarum dry respectively is ground into smalls, by resina liquidamberis and borneol
Smash into powder to pieces respectively；
(2) 430 parts and 150 parts of borneol of the addition resina liquidamberis into the alcohol of 1000 parts by weight, sealed soak 18 days, every 3
Soak is stirred primary, each mixing time 25 minutes by it, and filtering removes filter residue, obtains mixture A；
(3) 800 parts of Chinese prickly ash, 450 parts of Rosa roxburghii Tratt tree root, 450 parts of iron Chinese lute root, white flower are added into the alcohol of 9000 parts by weight
240 parts of snake, 350 parts of Cortex Eucommiae, 350 parts of ground bettle, 350 parts of polygonum cuspidate, 350 parts of turmeric, 350 parts of paniculate swallowwort, 350 parts of Rhizoma Chuanxiong, Wang Ling
350 parts of rouge, 350 parts of olibanum, 350 parts of myrrh, 350 parts of teasel root, parasitic 350 parts, 350 parts of radix achyranthis bidentatae, 350 parts of the stem pith of the rice-paper plant, the rhizome of davallia 350
Part, 350 parts of rhizoma cibotii, 350 parts of gentianae macrophyllae, 350 parts of Rhizoma Gastrodiae, 350 parts of ramulus cinnamomi, 350 parts of the root of fangji, 350 parts of the root of Chinese clematis, 350 parts of pawpaw, solely
350 parts, 350 parts of Rhizoma Et Radix Notopterygii, 350 parts of Caulis Spatholobi, 220 parts of dragon's blood, 220 parts of monkshood, 220 parts of cortex acanthopanacis, 220 parts of asarum living, sealing
It impregnates 18 days, stirred soak once every 3 days, it is uniform that each mixing time 20-3025 closes object B.
Test example 1
Skin irritation test
It selects New Zealand and plants White Rabbit 10, White Rabbit is randomly divided into 5 groups, every group 2 by male and female, weight 2-3Kg
Only.White Rabbit back backbone diamond wool is cut for 24 hours before experiment, unhairing range is respectively 3cm × 4cm.
The exterior-applied medical wine for uniformly smearing 1mL embodiment of the present invention 1-5 on the left of every group of White Rabbit on skin of unhairing respectively, makees
For control, the alcohol that 1mL concentration is 75% is correspondingly uniformly smeared on the right side of the White Rabbit on skin of unhairing.2 times a day, continuous to apply
It wipes 7 days, embrocates rear 1h record observation result every time daily.
For all White Rabbit whole bodies without any discomfort symptom, appetite is good, and depilation skin in the left and right sides is without red and swollen, red
Phenomena such as spot and exception, occurs.It is evaluated according to skin wound repair, the exterior-applied medical wine of the embodiment of the present invention belongs to nothing
Irritation.
Test example 2
Clinical test
300 rheumatism patients for selecting this test of voluntary participation, take randomized blocks, and patient is divided into treatment 1-5
Group and control group, every group each 50.Case is included in standard: according to People's Republic of China (PRC) traditional Chinese medicine industry standard GB/
TI6751.3-1997 Standards for Diagnosis and Curative Effect of Chinese Medical Symptom meets the case of " bi Zheng " diagnosis, excludes liver, kidney, cardiovascular and cerebrovascular etc.
Serious disease patient.Wherein cervical spondylosis 43, scapulohumeral periarthritis 35, pain in the loins 28, skelagia 35, rheumatic arthritis 36, four
It is acroanesthesia 21, soft tissue injury 28, bruise 24, gout 25, property bone fracture 25 new and old.The general money of each group patient
Difference in terms of expecting in comparison without statistics, P > 0.05 is comparable.
It treats 1-5 group: using the exterior-applied medical wine of embodiment 1-5 respectively, application method: on the cotton or the palm of the hand by liquid medicine
On dab affected part 1-2 minutes or medication steeping in wine saturating cotton soak affected part, 2 times a day, 7 days as one therapeutic course, totally 3 courses for the treatment of.
Control group: being relaxed liniment (national drug standard Z42020136) living using Moschus, and application method is same as above.
Efficacy assessment standard is as follows:
Recovery from illness: the conscious local pain of patient disappears, and part is without tenderness, and functional movement is normal, and affected part is comfortable.
Improve: patient is alleviated conscious local pain part, and local mild tenderness, functional movement part is normal, and affected part is comfortable
Sense increases.
Invalid: the conscious local pain of patient is without alleviation, and local tenderness is obvious, and functional movement is abnormal, and affected part comfort is not
Obviously.
The Clinical efficacy comparison for the treatment of group and control group the results are shown in Table 1.
Table 1
| Group | n | Recovery from illness | It improves | In vain | Total effective rate (%) |
| Treat 1 group | 50 | 30 | 17 | 3 | 94 |
| Treat 2 groups | 50 | 25 | 20 | 5 | 90 |
| Treat 3 groups | 50 | 22 | 24 | 4 | 92 |
| Treat 4 groups | 50 | 27 | 18 | 5 | 90 |
| Treat 5 groups | 50 | 20 | 26 | 4 | 92 |
| Control group | 50 | 15 | 21 | 14 | 72 |
As shown in Table 1, the total effective rate for the treatment of group is at least 90%, and the total effective rate of control group is 72%.Treatment group suffers from
The totall effective rate in clinical treatment of person is significantly higher than control group, and data difference is statistically significant (P < 0.05).
Safety evaluatio: blood routine, liver function, electrocardiogram discovery without exception after treatment 1-5 group patient treatment.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention are fallen within the scope of the claimed invention.
Claims (6)
1. a kind of exterior-applied medical wine for treating rheumatism, which is characterized in that be prepared from the following raw materials in parts by weight: Chinese prickly ash 750-800
Part, 400-450 parts of Rosa roxburghii Tratt tree root, 400-450 parts of iron Chinese lute root, 200-240 parts of agkistrodon, 300-350 parts of Cortex Eucommiae, ground bettle
300-350 parts, 300-350 parts of polygonum cuspidate, 300-350 parts of turmeric, 300-350 parts of paniculate swallowwort, 300-350 parts of Rhizoma Chuanxiong, Wang Ling rouge
300-350 parts, 300-350 parts of olibanum, 300-350 parts of myrrh, 300-350 parts of teasel root, 300-350 parts of parasitism, radix achyranthis bidentatae 300-350
Part, 300-350 parts of the stem pith of the rice-paper plant, 300-350 parts of the rhizome of davallia, 300-350 parts of rhizoma cibotii, 300-350 parts of gentianae macrophyllae, 300-350 parts of Rhizoma Gastrodiae, osmanthus
Branch 300-350 parts, 300-350 parts of the root of fangji, 300-350 parts of the root of Chinese clematis, 300-350 parts of pawpaw, 300-350 parts of Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii
300-350 parts, 300-350 parts of Caulis Spatholobi, 200-220 parts of dragon's blood, 200-220 parts of monkshood, 200-220 parts of cortex acanthopanacis, asarum
200-220 parts, 400-450 parts of resina liquidamberis, 150-180 parts of borneol, 10000 parts of alcohol.
2. the exterior-applied medical wine for the treatment of rheumatism according to claim 1, which is characterized in that by the raw material system of following parts by weight
At: 750 parts of Chinese prickly ash, 400 parts of Rosa roxburghii Tratt tree root, 400 parts of iron Chinese lute root, 220 parts of agkistrodon, 300 parts of Cortex Eucommiae, 300 parts of ground bettle, tiger
300 parts of cane, 300 parts of turmeric, 300 parts of paniculate swallowwort, 300 parts of Rhizoma Chuanxiong, 300 parts of Wang Ling rouge, 300 parts of olibanum, 300 parts of myrrh, teasel root
300 parts, parasitic 300 parts, 300 parts of radix achyranthis bidentatae, 300 parts of the stem pith of the rice-paper plant, 300 parts of the rhizome of davallia, 300 parts of rhizoma cibotii, 300 parts of gentianae macrophyllae, Rhizoma Gastrodiae 300
Part, 300 parts of ramulus cinnamomi, 300 parts of the root of fangji, 300 parts of the root of Chinese clematis, 300 parts of pawpaw, 300 parts of Radix Angelicae Pubescentis, 300 parts of Rhizoma Et Radix Notopterygii, 300 parts of Caulis Spatholobi,
200 parts of dragon's blood, 200 parts of monkshood, 200 parts of cortex acanthopanacis, 200 parts of asarum, 400 parts of resina liquidamberis, 150 parts of borneol, 10000 parts of alcohol.
3. the exterior-applied medical wine for the treatment of rheumatism according to claim 1, which is characterized in that the concentration of the alcohol is 75%.
4. the exterior-applied medical wine for the treatment of rheumatism according to claim 1, which is characterized in that the rheumatism includes cervical spondylosis, shoulder
Zhou Yan, pain in the loins, skelagia, rheumatic arthritis, numb limb, soft tissue injury, bruise, gout, new and old property bone fracture.
5. a kind of preparation method of the exterior-applied medical wine for the treatment of rheumatism described in claim 1, which is characterized in that including following step
It is rapid:
(1) by Chinese prickly ash, Rosa roxburghii Tratt tree root, iron Chinese lute root, agkistrodon, Cortex Eucommiae, ground bettle, polygonum cuspidate, turmeric, paniculate swallowwort, Rhizoma Chuanxiong, Wang Ling
Rouge, olibanum, myrrh, teasel root, parasitism, radix achyranthis bidentatae, the stem pith of the rice-paper plant, the rhizome of davallia, rhizoma cibotii, gentianae macrophyllae, Rhizoma Gastrodiae, ramulus cinnamomi, the root of fangji, the root of Chinese clematis, pawpaw,
Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, dragon's blood, monkshood, cortex acanthopanacis, asarum dry respectively is ground into smalls, and resina liquidamberis and borneol are smash respectively
It is broken into powder, weighs each raw material by formula ratio；
(2) Chinese prickly ash, Rosa roxburghii Tratt tree root, iron Chinese lute root, agkistrodon, Cortex Eucommiae, ground bettle, tiger are added into the alcohol of 9000 parts by weight
Cane, turmeric, paniculate swallowwort, Rhizoma Chuanxiong, Wang Ling rouge, olibanum, myrrh, teasel root, parasitism, radix achyranthis bidentatae, the stem pith of the rice-paper plant, the rhizome of davallia, rhizoma cibotii, gentianae macrophyllae, day
Fiber crops, ramulus cinnamomi, the root of fangji, the root of Chinese clematis, pawpaw, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Caulis Spatholobi, dragon's blood, monkshood, cortex acanthopanacis, asarum, sealed soak 15-20
It, filtering removes filter residue, obtains mixture A；
(3) resina liquidamberis and borneol are added into the alcohol of 1000 parts by weight, sealed soak 15-20 days, filtering removed filter residue, obtains
To mixture B；
(4) the mixture A and mixture B is uniform.
6. the preparation method of the exterior-applied medical wine for the treatment of rheumatism according to claim 5, which is characterized in that in step (2) and
In the soaking process of step (3), soak is stirred once every 3 days, each mixing time 20-30 minutes.
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Application publication date: 20191018 |