CN104815232A - Traditional Chinese medicine preparation for treating primary pulmonary hypertension and preparation method thereof - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating primary pulmonary hypertension. The traditional Chinese medicine preparation is prepared from the following raw materials in proportion by weight: gastrodia elata, uncaria, fructus psoraleae, concha haliotidis, raw oyster shell, salvia miltiorrhiza, fried peach seed, red flower, Ligusticum wallichii, rhizoma cyperi, rhizoma phragmitis, lalang grass rhizome, monkshood, raw white atractylodes rhizome, Tuckahoe, grifola, white paeony root, cassia twig, Tetrapanax papyriferus, rhizoma alismatis, medicinal cyathula root, raw semen coicis, Astragalus membranaceus and fried semen armeniacae amarae. The traditional Chinese medicine preparation has the functions of calming liver wind, activating blood to promote menstruation, dissipating blood stasis, stopping pain, clearing away the heart-fire, relieving restlessness, and removing heat to promote salivation; the primary pulmonary hypertension can be effectively treated.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of primary pulmonary hypertension.The invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Primary pulmonary hypertension (primarypulmonaryhypertension) is a Uncommon Diseases, because of its etiology unknown, and is different from condary pulmonary hypertension.The basic lesion of primary pulmonary hypertension causes clump property pulmonary artery disease, and the single causative factor of neither one its pathogenic process soluble, is likely the long-term coefficient final result of some causative agent.Primary pulmonary hypertension foundation pulmonary artery pressure and cardiac output are by undue for its clinical warp 3 stages: initial stage, later stage and final period.At the initial stage (I phase): pulmonary artery pressure raises gradually, cardiac output is normal, and patient is usually asymptomatic, does not only feel well when aggravating activities; Later stage (II phase): pulmonary artery pressure is stable to be raised, and cardiac output still keeps normal, can occur symptomatology, and the clinical state of an illness is still stable; Final (III phase): the fixing few change of pulmonary hypertension, cardiac output declines, and symptom Progressive symmetric erythrokeratodermia increases the weight of, and cardiac function loses compensatory.
Current treatment mainly should be carried out for aspects such as vasoconstriction, inner film injury, thrombosis and cardiac insufficiencys, is intended to recover pulmonary vascular tension force, resistance and pressure, improves cardiac function, increases cardiac output, improves life quality; Western medicine is just treated on the surface of disease, and long-term taking Western medicine, not only can produce and buy the property of medicine, also can cause further damage to the health of patient, too increase the economic pressures of patient home, patient is generally beyond affordability, and some is abandoning cure even simultaneously.Dialectical treating be good at by Chinese medicine, fundamentally nurses one's health the health of patient, reaches the object for the treatment of both the principal and secondary aspects of a disease, is patient's relieving the pain caused by diseases.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation, it is obvious, cheap, with strong points that this Chinese medicine preparation has curative effect for treatment primary pulmonary hypertension, has no side effect, the feature of taking convenience.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment primary pulmonary hypertension.
Inventor is in clinical treatment practice for many years, observe the misery that primary pulmonary hypertension is brought to patient, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of primary pulmonary hypertension repeatedly, the present invention selects Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Fructus Psoraleae, Concha Haliotidis, Concha Ostreae, Radix Salviae Miltiorrhizae, Semen Persicae (parched), Flos Carthami, Rhizoma Chuanxiong, Rhizoma Cyperi, Rhizoma Phragmitis, Rhizoma Imperatae, Radix Aconiti Lateralis Preparata, Rhizoma Atractylodis Macrocephalae, Poria, Polyporus, the Radix Paeoniae Alba, Ramulus Cinnamomi, Medulla Tetrapanacis, Rhizoma Alismatis, Radix Cyathulae, Semen Coicis, the Radix Astragali, Semen Armeniacae Amarum (parched) combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is suppressing the hyperactive liver to relieve the wind syndrome, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, clear away heart-fire relieving restlessness, effect of clearing away heat and promoting production of body fluid, thus effectively can treat primary pulmonary hypertension.
The effect of Chinese medicine of the present invention:
Wherein:
Rhizoma Gastrodiae: be the dry tuber of orchid Rhizoma Gastrodiae Gastrodia elata Blume..Nature and flavor: sweet are flat.Return Liver Channel.Effect: suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.Dizzy for having a headache, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, tetanus.Pharmaceutical research shows, Rhizoma Gastrodiae has significantly calm and anticonvulsant action.Rhizoma Gastrodiae is sweet flat, specially enter Liver Channel, function endogenous wind stopping relieving convulsion, and Gan Run is not strong, acts on gentle, the panacea of endogenous wind for it, can be used for treating the liver-wind stirring up internally caused by the various cause of disease, and infantile convulsion is twitched, no matter cold and heat and asthenia and sthenia, and all can compatibility application.
Ramulus Uncariae Cum Uncis: be the dry stem and branch with belt hook of Maguireothamnus speciosus Ramulus Uncariae Cum Uncis Uncaria rhynchOphylla (Miq.) Jacks., Ramulus Uncariae macrophyllae Uncaria macrophylla Wall., Ramulus Uncariae Cum Uncis Uncaria hirsuta Havil., Uncaria sinensis (Oliv.) Havil. Uncaria sinensis (Oliv.) Havil. or stockless fruit Ramulus Uncariae Cum Uncis Uncaria sessilifructusRoxb..Nature and flavor: sweet are cool.Return liver, pericardium channel.Effect: heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; Hypertension."Ben hui said:" teng, wind phlegm and arresting convulsion, chronic, Ann guest mind attack blain cuo medicine also.Mr. Qian Zhongyang says: an ancient unit of weight rattan, warm, flat, nontoxic, baby section treasure's.Their sexual chik lee, wind phlegm, KaiQi closed, Ann chronic ulcerated in haste in an instant, with internal accumulation of cold, hemp, GuiFa with Qin, solution of severe heat, like the previous, remove the table of evil, with check, park long lag of food, with rat glue, platycodon grandiflorum, qiang, prevent, loc hair blain of cuo ambiguously not now also, but not dry wind evil, and to and in the article.But decoct just unable for a long time, his medicine fry cooked more than ten of waiting is boiled, drop into and namely rise, quite also capable.Destemmingly purely use tender hook, power ten times.
Fructus Psoraleae: be the fruit of legumes psoraleae Psoralea corylifolia L..Nature and flavor: pungent, bitter, temperature.Return kidney, spleen channel.Effect: kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, helping inspiration to relieve asthma.This product energy kidney-replenishing, warm spleen sun, stopping leak rushes down, for controlling the key medicine of deficiency of spleen-YANG and kidneyYANG.This product is worked hard warm-dryness syndrome, can warming and recuperating the gate of life, and replenishing kidney, strengthening waist, tonifying YANG, controlling nocturnal emission with astringent drugs, reducing urination, for controlling the key medicine of insufficiency of kidney-YANG, instability of kidney-QI.Modern age works out again, and the effective ingredient in Fructus Psoraleae has the effect of blood vessel dilating.
Concha Haliotidis: be the shell of Bao Ke animal Haliotis diversicolor (sea at the bottom of light certainly) Haliotis diversicolor Reeve, haliotis discus hannai Ino (sea at the bottom of hair certainly) Haliotis discus hannai Ino, sheep Bao (sea certainly) Haliotisovina Gmelin, haliotis ruber Haliotis ruber (Leach), ear Bao Haliotis asininaLinnaeus or white Bao Haliotis laevigata (Donovan).Nature and flavor: salty, cold.Return Liver Channel.Effect: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.Dizzy for having a headache, cataract, blurring of vision, optic atrohic blindness nyctalopia." Bencao Jingshu ": Concha Haliotidis, be meridian of Foot-JUE YIN medicine also.The moon of fainting enough is had one's ideas straightened out in order, visual acuity is obtained from the sufficient blood supply of the eyes, and blood deficiency has heat, then here raw optic atrohic blindness also hide from view bitterly.Salty-cold enter blood heat extraction, so all order diseases can be led also.
Concha Ostreae: be the shell of Ostreidae animal long Concha Ostreae Ostrea gigas Thunberg, Dalian Bay Concha Ostreae Ostreatalienwhanensis Grosse or Crassostrea rivularis Ostrea rivularis Gould etc.Nature and flavor: salty, be slightly cold.Return liver, gallbladder, kidney channel.Effect: suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving, convergence are astringent or styptic treatment for spontaneous sweating.Research shows: Concha Ostreae is also containing vitamin B12, and this is that general food lacked, and the brill element in vitamin B12 is the indispensable material of prevention pernicious anemia, and thus Concha Ostreae has again the effect enlivening hemopoietic function.Concha Ostreae salty in the mouth, hard masses softening and resolving.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia/miltiorrhizaBge.Nature and flavor: bitter, are slightly cold.Gui Jing: enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed.Containing cryptotanshinone, dihydrotanshinone in red sage formulation, there is inhibitory action to external staphylococcus, escherichia coli, degeneration bacillus.Radix Salviae Miltiorrhizae energy blood circulation promoting and blood stasis dispelling, to the hypertrophy eliminating hepatic fibrosis connective tissue, also may have certain effect.Modern medicine experiment proves, Radix Salviae Miltiorrhizae also has anti-platelet aggregation, reduces the function of blood viscosity and the inside and outside blood coagulation system of adjustment, is the natural Chinese medicine that a kind of safety treats again thrombus disease reliably.For costa sternales hypochondriac pain, improve liver microcirculation, can suppress or alleviate hepatocellular degeneration, necrosis and inflammatory reaction, promote liver cell regeneration, and have anti-fibrosis effect.
Semen Persicae (parched): be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunusdavidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.The power of Semen Persicae blood stasis dispelling is comparatively strong, also known as stasis-breaking drug, is used for the treatment of blood stasis, WEIJIA, often joins Flos Carthami, Radix Angelicae Sinensis.Semen Persicae is improved effect to blood flow retardance, blood obstacle, and each internal organs can be made respectively to organize functional recovery normal.
Flos Carthami: be the tubular corolla of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: temperature, pungent.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.The pungent loose temperature of Flos Carthami is led to, and specially enters blood system, can blood circulation promoting and blood stasis dispelling, and stimulate the menstrual flow pulse-taking, and the mutual reinforcements between such as normal and Semen Persicae, Radix Angelicae Sinensis, Rhizoma Chuanxiong are for use.Flos Carthami has blood vessel dilating effect.Carthamus yellow can obviously extend blood plasma recalcification time, prothrombin time and clotting time." Amplification on Materia Medica addendum ": " Flos Carthami, broken stagnant blood, nourishes blood.Multiplex then removing blood stasis is few with then nourishing blood." crude extract from carthamus tinctorius L. with water has slight excited heart, increases the effect of coronary flow, have myocardial ischemia and alleviate effect, and make decreased heart rate, the amplitude that electrocardiogram S-T section is raised significantly declines, and also has anticoagulant and increases fibrinolysis activity.
Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Nature and flavor: pungent, temperature.Return liver, gallbladder, heart channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.The pungent loose temperature of this product is led to, can top, up mountain peak, assigns the sea of blood, outer thorough fur, bypass extremity, can invigorate blood circulation and can circulation of qi promoting, and it is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.Rhizoma Chuanxiong has obvious sedation.The in vitro testses such as antibacterial action: Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Rhizoma Chuanxiong water logging agent (1: 3) also has inhibitory action to some pathogenic dermatophytes in vitro.This product contains ligustrazine can suppress vascular smooth muscle contraction, coronary artery dilator, increase coronary flow, improve myocardial ischemia situation and Mesentery microcirculation, increase brain and LBF amount, reduce peripheral vascular resistance, can also anticoagulant, can the formation of preventing thrombosis in advance, there is good curative effect to cardiovascular and cerebrovascular disease.
Rhizoma Cyperi: be the dry rhizome of sedge dried tuber Cyperus rotundus L..Nature and flavor: pungent, micro-hardship, micro-sweet are flat.Return liver, spleen, tri-jiao channel.Effect: promoting QI circulation for relieving depression, menstruction regulating and pain relieving, antiabortive, regulate the flow of vital energy Shu Yu, harmonizing the liver and stomach.The pungent loose hardship of this product is let out, and is the key medicine of depressed liver-energy dispersing and QI regulating, can be used for all pain cards caused by irritability stasis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": adjust the gas in blood, dissipating depression of QI, alleviating distention in middle-JIAO, helps digestion." book on Chinese herbal medicine is looked for the truth ": Rhizoma Cyperi, exclusive dissipating depression of QI falls apart gas, and with Radix Aucklandiae circulation of qi promoting, looks are with real different, and Radix Aucklandiae abnormal smells from the patient hardship is bad, therefore ventilation is very prompt, and this is then bitter and not very, therefore resolving depression is in the majority, and property and in the Radix Aucklandiae, therefore can add and subtract discrepancy, thinks circulation of qi promoting obstruction-removing prescription, otherwise should this and those ears unsuitable.
Rhizoma Phragmitis: be the fresh or dry rhizome of grass phragmites communis Phragmites communis Trin..Nature and flavor: sweet, cold.Return lung meridian, stomach warp.Function: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Rhizoma Phragmitis one medicine, is mainly used in following two aspects clinically, can clearing away lung-heat and evacuation of pus of eliminating the phlegm, again can clearing away stomach-heat and the preventing or arresting vomiting that promotes the production of body fluid.Though its attribute is trembled with fear, slightly sweet flavor and power use lung heat clearing stomach, can only as auxiliary medicine.But, it has an advantage, and namely property is not grown greasy, promotes the production of body fluid and does not love heresy, and all epidemic febrile disease deep loves are defended, gas, or if any the syndrome that impairment of body fluid is thirsty after calentura, all can apply.
Rhizoma Imperatae: be the rhizome of grass perennial herb Herba Imperatae Imperata cylindrica.Nature and flavor: sweet, cold.Return lung, stomach, urinary bladder channel.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema." Bencao Jingshu " is recorded: impairment caused by overstrain void is won, must interior-heat, and Rhizoma Imperatae is sweet can spleen reinforcing, sweet, though cold and do not violate stomach.Gan Hanneng is except interior-heat, therefore main impairment caused by overstrain void is won.Strengthening the spleen so invigorating middle warmer, heat extraction so QI invigorating, the beneficial blood of sweet energy, heat in blood is the stasis of blood then, and the stasis of blood is then closed, and closes then cold and heat and does, cold and cool blood, sweet beneficial blood, heat go then blood and, and then stagnation resolvation and close logical, general rule cold and heat are from only also.Dysuria, due to interior-heat also, pyrolysis then just diarrhea.Pouring person, caused by blood system deficiency-heat also, removing heat from blood benefit blood, then drench spontaneous recovery, and the exopathogenic heat of the intestines and stomach is explained by oneself, and body fluid is raw and yearningly also stop.Blood stored in the liver and main muscle, cool liver of enriching blood, then muscle is hard.Heat in blood then collapses, and removing heat from blood and blood, then collapse spontaneous recovery.
Radix Aconiti Lateralis Preparata: be the dry tuber of aroid Herba Typhonii gigantei Typhonium giganteum Engl..Nature and flavor: pungent, warm, poisonous.Return stomach, Liver Channel.Effect: dispel the wind expectorant, and arresting convulsion is jerked, detoxicating and resolving stagnation of pathogens pain relieving.Stop up for middle wind-phlegm, facial hemiparalysis, language is puckery stuttering, and syncope due to accumulation of phlegm is had a headache, migraine and general headache, sore throat pharyngalgia, tetanus; External treatment scrofula sucutaneous nodule, venom, tetanus, carbuncle.
Rhizoma Atractylodis Macrocephalae: be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, the Rhizoma Atractylodis Macrocephalae can air making-up and spleen enlivening, again can dampness diuretic, is the key medicine of the spleen strengthening and damp drying.To rule together asthenia, the weak person of overstrain.Rhizoma Atractylodis Macrocephalae antibacterial action is obvious: infusion has inhibitory action to acrothesium floccosum, star nocardia in vitro.Decoct also has inhibitory action to meningococcus.The Rhizoma Atractylodis Macrocephalae also has the function promoting hemopoietic.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, is the key medicine of promoting diuresis to eliminate damp pathogen.Treatment water wet the edema of expert time, often join Rhizoma Alismatis, Polyporus.Poria decoct has obvious sedation." modality ": " cure mainly Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side." this product is by heart-spleen boosting and tranquilizing mind.Be used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.
Polyporus: be the dry sclerotia of On Polyporaceae Polyporus Polyporus umbellatus (Pers.) Fries.Nature and flavor: sweet, light, flat.Return kidney, urinary bladder channel.Effect: promoting diuresis to eliminate damp pathogen.Polyporus and Poria compatibility, Polyporus specializes in promoting diuresis to eliminate damp pathogen, and diuretic effect is strong in Poria, and Poria is not only mended but also sharp, and holding concurrently can spleen invigorating mind calming.
The Radix Paeoniae Alba: be the dry root of dicotyledon ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: cool, picric acid, is slightly cold.Effect: easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receives antiperspirant.Research shows: the paeoniflorin contained in the Radix Paeoniae Alba has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.This product energy nourishing the liver blood, holding back liver-yin, subduing the hyperfunction of the liver sun, dispersing liver-energy, can delay again that contraction is anxious, relieve the pain pain, is the good medicine of the various pain for the treatment of Liver Channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " purgation of spleen excess heat, only abdomen pain, sealing rushes down, and receives adverse flow of liver-QI pain, takes good care of conscience spleen channel blood, relax through sending down the abnormal ascending QI, only irritability pain." " herbal classic " Radix Paeoniae, though respectively in vain not red, the two is master to some extent respectively.So seek and unravel silk it and cure mainly all diseases, one is that replenishing blood and nourishing liver spleen is Kidney-Yin, and receives and take the photograph the at random of temper, and throwing off restraint of irritability is horizontal, then the Radix Paeoniae Alba.
Ramulus Cinnamomi: be the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor: acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Cure mainly exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; WEIJIA is lumpd; The thoracic obstruction; Cardiopalmus; Phlegm retention." Changsha medicine solution " carries: " enter liver man and promoting the circulation of blood divides, determine meridians and reach Rong Yu.Kind solution ailment said due to cold or exposure, adjusts wood gas most.The detrapping of sending up the lucid YANG, the punching of the turbid descending the moon is inverse, the anxious contraction of relaxing muscles and tendons feeling pulse; The heap soil or fertilizer over and around the roots resistance in profit joint, fall apart and suppress, pain relieving Chu, the meridian dredging, opens numbness puckery, very dries cold.Only renal mass, more pacifies palpitation with fear." modern medicine study confirm, Ramulus Cinnamomi can effectively blood vessel dilating, promote diaphoresis, contained cinnamic aldehyde, natrium cinnamicum have antipyretic, analgesia, calmness, anticonvulsant action, in addition Ramulus Cinnamomi antibacterial, antiviral effect in addition.Ramulus Cinnamomi is warm in nature, and the kind gas that activates yang, can change YIN-cold, temperature three-way meridian, for all pain cards of congealing cold with blood stasis.
Medulla Tetrapanacis: be the dry stem pith of Araliaceae rice-paper plant Tetrapanax papyriferus (Hook.) K.Koch.Nature and flavor: sweet, light, be slightly cold.Attach to the lung and stomach meridians.Effect: clear snobbish water; Lactogenesis.The puckery pain of main stranguria; Dysuria; Edema; Jaundice; Damp-warm diseases; Oliguria with reddish urine; Puerperal, breast was few; Amenorrhea; Leukorrhagia.Modern pharmacology is studied: Medulla Tetrapanacis has diuresis, and obviously can increase urine potassium output, has effects such as promoting galactopoiesis.Medulla Tetrapanacis polysaccharide has certain immunity moderation and antioxidative effect.
Rhizoma Alismatis: be the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor: sweet, cold.Return kidney, urinary bladder channel.Effect: diuresis, clearing away damp-heat.For edema, the dysuria of retention of water-damp in the body.This product enters kidney, urinary bladder channel, and kind clear damp-heat in lower-JIAO cold in nature, is used for syndrome of dampness-heat in lower jiao.Rhizoma Alismatis has significant diuresis, can promote muriatic excretion, increases urine volume, more obvious to nephritis patient diuresis, has blood pressure lowering, hypoglycemic activity, also has lipotropic effect.
Radix Cyathulae: be the dry root of amaranthaceous plant Radix Cyathulae Cyathula officinalis Kuan.Nature and flavor: sweet, micro-hardship, flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.
Semen Coicis: be the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L. var.ma-yuen (Roman.) Stapf.Nature and flavor: sweet, light, cool.Return spleen, stomach, lung meridian.Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment pain relieving, clearing away heat and discharging pus.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: tonifying Qi and lifting yang, consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.On the books in " book on Chinese herbal medicine converges and says ": " Radix Astragali, tonifying the lung spleen invigorating defend arresting sweating in fact, and the medicine of wind dispelling fortune poison also.Therefore the people of yang deficiency, spontaneous perspiration frequently comes, be exterior deficiency and interspaces of skin and muscles being loose also, he the Radix Astragali can be defended and arresting sweating in fact; The card of typhoid fever, row is delivered and evil no sweating, and be interior deficiency and also weary in healthy energy, the Radix Astragali can help Tianjin to help antiperspirant; The disease of harmful wind, inclined invasion of vessels and brothers are not with person, and the Radix Astragali can flourish muscles and bones; The card of carbuncle and ulcer, pus and blood internal ulceration, deficiency of YANG QI and do not hold back person, the Radix Astragali can granulation promoting meat, and the erosion of vulva can not rise and send out again, deficiency of YANG QI and unhealed, and the Radix Astragali can granulation promoting meat." this product all has inhibitory action to dysentery bacterium, anthrax bacillus, α-hemolytic streptococcus, beta hemolytic streptococcus, diphtheria corynebacterium, bacillus pseudodiphthericus, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, bacillus subtilis etc. in vitro.
Semen Armeniacae Amarum (parched): be the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. (bitter Fructus Pruni) Prunus armeniaca L.var.ansu Maxim., Siberia Fructus Pruni (Prunus armeniaca L.var.ansu Maxim.) Prunus sibirica L., prunus mandshuricaKoehne Prunus mandshurica (Maxim.) Koehne or Fructus Pruni Prunus armeniaca L..Nature and flavor: bitter, tepor; Slightly poisonous.Return lung, large intestine channel.Effect: sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.
Side's solution of the present invention is: Rhizoma Gastrodiae suppressing the hyperactive liver to relieve the wind syndrome in side, Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion, Fructus Psoraleae kidney invigorating and YANG supporting, warming spleen and stopping diarrha, Concha Haliotidis, Concha Ostreae suppressing the hyperactive liver and subsiding YANG, Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, clear away heart-fire relieving restlessness, above Six-element is monarch drug altogether, first suppressing the hyperactive liver to relieve the wind syndrome, the kidney invigorating YANG hyperactivity suppressing is fundamentally carried out, the phenomenon of reduction of patient pulmonary hypertension, also there is the effect of stasis-dispelling and pain-killing, the relieving restlessness that clears away heart-fire in addition, can treat the pulmonary hypertension because thrombosis causes, the relieving restlessness that clears away heart-fire in addition can control patient's emotion, thus reaches the object of the primary pulmonary hypertension for the treatment of.Semen Persicae (parched), Flos persicae promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, Rhizoma Chuanxiong is invigorated blood circulation promoting the circulation of blood, Rhizoma Cyperi promoting QI circulation for relieving depression, menstruction regulating and pain relieving, Rhizoma Phragmitis, Rhizoma Imperatae cooling blood for hemostasis, clearing away heat and promoting production of body fluid, Radix Aconiti Lateralis Preparata eliminates the phlegm arresting convulsion, and above seven tastes are ministerial drug altogether, add promoting blood circulation to restore menstrual flow, the effect of eliminating stasis to stop pain, can the formation of preventing thrombosis in advance, and then can treat primary pulmonary hypertension, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, Poria, Polyporus promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, the Radix Paeoniae Alba is enriched blood easing the affected liver, suppressing the hyperactive liver pain relieving, Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, Medulla Tetrapanacis, the clear snobbish water of Rhizoma Alismatis, Radix Cyathulae easing joint movement, Semen Coicis spleen invigorating eliminating dampness by diuresis, eliminating impediment pain relieving, Radix Astragali tonifying Qi and lifting yang, the cough-relieving of Semen Armeniacae Amarum (parched) sending down the abnormal ascending QI, above a few taste is adjuvant drug altogether, can alleviate other complication that primary pulmonary hypertension is brought, and have anti-inflammation, the effect of promoting blood circulation to restore menstrual flow, gets through pulmonary artery, blood vessel stasis blocking near heart, is that blood operation is smooth, thus reaches the object for the treatment of primary pulmonary hypertension, fundamentally can also strengthen the body constitution of patient, patient is recovered as early as possible.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of suppressing the hyperactive liver to relieve the wind syndrome, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, the relieving restlessness that clears away heart-fire, clearing away heat and promoting production of body fluid, effectively can treat primary pulmonary hypertension.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Rhizoma Gastrodiae 10-20 part, Ramulus Uncariae Cum Uncis 15-25 part, Fructus Psoraleae 10-20 part, Concha Haliotidis 25-35 part, Concha Ostreae 25-35 part, Radix Salviae Miltiorrhizae 15-25 part, Semen Persicae (parched) 7-17 part, Flos Carthami 4-14 part, Rhizoma Chuanxiong 10-20 part, Rhizoma Cyperi 10-20 part, Rhizoma Phragmitis 19-29 part, Rhizoma Imperatae 19-29 part, Radix Aconiti Lateralis Preparata 7-17 part, Rhizoma Atractylodis Macrocephalae 19-29 part, Poria 15-25 part, Polyporus 13-23 part, Radix Paeoniae Alba 10-20 part, Ramulus Cinnamomi 13-23 part, Medulla Tetrapanacis 3-9 part, Rhizoma Alismatis 10-20 part, Radix Cyathulae 13-23 part, Semen Coicis 19-29 part, Radix Astragali 25-35 part, Semen Armeniacae Amarum (parched) 7-17 part.
Wherein be preferably: 15 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 20 parts, Fructus Psoraleae 15 parts, Concha Haliotidis 30 parts, Concha Ostreae 30 parts, Radix Salviae Miltiorrhizae 20 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Rhizoma Chuanxiong 15 parts, Rhizoma Cyperi 15 parts, Rhizoma Phragmitis 24 parts, Rhizoma Imperatae 24 parts, Radix Aconiti Lateralis Preparata 12 parts, Rhizoma Atractylodis Macrocephalae 24 parts, 20 parts, Poria, Polyporus 18 parts, the Radix Paeoniae Alba 15 parts, Ramulus Cinnamomi 18 parts, Medulla Tetrapanacis 6 parts, Rhizoma Alismatis 15 parts, Radix Cyathulae 18 parts, Semen Coicis 24 parts, the Radix Astragali 30 parts, Semen Armeniacae Amarum (parched) 12 parts.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.
The preferred preparation method of the present invention is decoction, and its preparation method is as follows:
Step one: by weight proportion of the present invention, takes Fructus Psoraleae, Semen Coicis bundle becomes medicated bag, be put in water and soak 40-45 minute, for subsequent use;
Step 2: by weight proportion of the present invention, takes Semen Persicae (parched), Radix Aconiti Lateralis Preparata, Semen Armeniacae Amarum (parched) grinds to 200 mesh sieves, for subsequent use;
Step 3: by weight proportion of the present invention, take Concha Haliotidis, Concha Ostreae is put into after marmite adds step one immersion and is remained cold water, exceed powder 3-4 centimetre, after being fried boiling with high heat, again with 30-40 minute at a simmer, filter, obtain filtrate, the water of 3-4 centimetre is added in residue medicinal residues, then Radix Salviae Miltiorrhizae is added, Rhizoma Cyperi, Rhizoma Phragmitis, Rhizoma Imperatae, Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Cyathulae, the Radix Astragali decocts 20-30 minute, add Rhizoma Gastrodiae subsequently, Ramulus Uncariae Cum Uncis, Rhizoma Chuanxiong, Poria, Polyporus, Medulla Tetrapanacis, medicated bag in Rhizoma Alismatis and step one, continue to decoct 20-30 minute, finally add Flos Carthami, Ramulus Cinnamomi decocts 10 minutes, filter, obtain filtrate, merge twice filtrate, filter, waste, for subsequent use,
Step 4: by gained powder Homogeneous phase mixing in step 2 in the medicinal liquid of step 3, both the Chinese medicine decoction for the treatment of primary pulmonary hypertension of the present invention.
Medicine suppressing the hyperactive liver to relieve the wind syndrome of the present invention, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, clear away heart-fire the effect such as relieving restlessness, clearing away heat and promoting production of body fluid, and curative effect is obvious, cheap, with strong points, have no side effect, taking convenience, the mode that this Chinese medicine preparation adopts is treated and fundamentally can be carried out conditioning health, and recuperating cures the disease combines, accelerate the improvement of the state of an illness, according to clinical 196 routine patient view statistics, to use after a course for the treatment of of medicine of the present invention total effective rate 96% after 89.8%, two courses for the treatment of of total effective rate.
Detailed description of the invention
Embodiment one, 10 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 15 parts, Fructus Psoraleae 10 parts, Concha Haliotidis 25 parts, Concha Ostreae 25 parts, Radix Salviae Miltiorrhizae 15 parts, Semen Persicae (parched) 7 parts, 4 parts, Flos Carthami, Rhizoma Chuanxiong 10 parts, Rhizoma Cyperi 10 parts, Rhizoma Phragmitis 19 parts, Rhizoma Imperatae 19 parts, Radix Aconiti Lateralis Preparata 7 parts, Rhizoma Atractylodis Macrocephalae 19 parts, 15 parts, Poria, Polyporus 13 parts, the Radix Paeoniae Alba 10 parts, Ramulus Cinnamomi 13 parts, Medulla Tetrapanacis 3 parts, Rhizoma Alismatis 10 parts, Radix Cyathulae 13 parts, Semen Coicis 19 parts, the Radix Astragali 25 parts, Semen Armeniacae Amarum (parched) 7 parts.
Embodiment two, 15 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 20 parts, Fructus Psoraleae 15 parts, Concha Haliotidis 30 parts, Concha Ostreae 30 parts, Radix Salviae Miltiorrhizae 20 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Rhizoma Chuanxiong 15 parts, Rhizoma Cyperi 15 parts, Rhizoma Phragmitis 24 parts, Rhizoma Imperatae 24 parts, Radix Aconiti Lateralis Preparata 12 parts, Rhizoma Atractylodis Macrocephalae 24 parts, 20 parts, Poria, Polyporus 18 parts, the Radix Paeoniae Alba 15 parts, Ramulus Cinnamomi 18 parts, Medulla Tetrapanacis 6 parts, Rhizoma Alismatis 15 parts, Radix Cyathulae 18 parts, Semen Coicis 24 parts, the Radix Astragali 30 parts, Semen Armeniacae Amarum (parched) 12 parts.
Embodiment three, 20 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 25 parts, Fructus Psoraleae 20 parts, Concha Haliotidis 35 parts, Concha Ostreae 35 parts, Radix Salviae Miltiorrhizae 25 parts, Semen Persicae (parched) 17 parts, 14 parts, Flos Carthami, Rhizoma Chuanxiong 20 parts, Rhizoma Cyperi 20 parts, Rhizoma Phragmitis 29 parts, Rhizoma Imperatae 29 parts, Radix Aconiti Lateralis Preparata 17 parts, Rhizoma Atractylodis Macrocephalae 29 parts, 25 parts, Poria, Polyporus 23 parts, the Radix Paeoniae Alba 20 parts, Ramulus Cinnamomi 23 parts, Medulla Tetrapanacis 9 parts, Rhizoma Alismatis 20 parts, Radix Cyathulae 23 parts, Semen Coicis 29 parts, the Radix Astragali 35 parts, Semen Armeniacae Amarum (parched) 17 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept out-patient 196 example for medical treatment.Wherein male 100 example, women 96 example, M-F 1.04:1,69 years old mean age, average course of disease 1 year.
Two, Therapeutic Method:
According to Medications Example two of the present invention, and preferred preparation method, weighting raw materials (daily dose), filter and remove residue after decocting, services once, decoction being taken warmly sooner or later.It within 15 days, is a course for the treatment of.
Three, efficacy assessment standard
1, cure: each clinical symptom disappearance of primary pulmonary hypertension, dyspnea, chest pain, the symptom such as dizzy disappear completely, and body constitution is restored, and indices inspection is all normal;
2, take a turn for the better: each clinical symptoms of primary pulmonary hypertension obviously alleviates, dyspnea, chest pain, the symptom such as dizzy turn for the better by and large, and body constitution is progressively recovered, and indices recovers gradually.
3, do not heal: primary pulmonary hypertension clinical symptoms is without any improvement.
Four, therapeutic outcome statistics
Wherein: total effective rate=cure rate+improvement rate
Can find therapeutic effect clearly by above data treatment total effective rate, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness in treatment primary pulmonary hypertension, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Model case and curative effect:
Case one, Lee, female, 59 years old, patient's body constitution is always bad, the last time haves a medical check-up and checks out to suffer from primary pulmonary hypertension, patient has obvious dyspnea, chest pain, dizzy symptom, patient is unwilling to take Western medicine, determine the Therapeutic Method adopting Chinese medicine, adopt made decoction in the embodiment of the present invention two, after patient takes two courses for the treatment of, dyspnea, chest pain, dizzy symptom is clearly better, for consolidate curative effect, continue to take two courses for the treatment of, patient clinical symptom disappears completely, obvious sensation body constitution is also enhanced, the mental status also improves, hospital is gone to check, indices is all normal, recovery from illness.
Case two, Bai, man, 74 years old, patient has dyspnea in the recent period, dizzy symptom, time tired, sensation obviously increases the weight of, sometimes obviously cardiopalmus can be felt, the symptom such as weak, remove examination in hospital, be diagnosed as primary pulmonary hypertension, carry out here treatment, adopt made decoction in the embodiment of the present invention two, after patient takes two courses for the treatment of, sensory symptoms obviously alleviates, dizzy, the symptom such as weak is obviously improved, breathe smooth and easy, the mental status is improved, continue to take a course for the treatment of, patient clinical symptom disappears completely, body constitution also improves, activity freely, without other malaise symptoms, remove examination in hospital, indices all shows normally, recovery from illness.
Claims (4)
1. treat the Chinese medicine preparation of primary pulmonary hypertension for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Rhizoma Gastrodiae 10-20 part, Ramulus Uncariae Cum Uncis 15-25 part, Fructus Psoraleae 10-20 part, Concha Haliotidis 25-35 part, Concha Ostreae 25-35 part, Radix Salviae Miltiorrhizae 15-25 part, Semen Persicae (parched) 7-17 part, Flos Carthami 4-14 part, Rhizoma Chuanxiong 10-20 part, Rhizoma Cyperi 10-20 part, Rhizoma Phragmitis 19-29 part, Rhizoma Imperatae 19-29 part, Radix Aconiti Lateralis Preparata 7-17 part, Rhizoma Atractylodis Macrocephalae 19-29 part, Poria 15-25 part, Polyporus 13-23 part, Radix Paeoniae Alba 10-20 part, Ramulus Cinnamomi 13-23 part, Medulla Tetrapanacis 3-9 part, Rhizoma Alismatis 10-20 part, Radix Cyathulae 13-23 part, Semen Coicis 19-29 part, Radix Astragali 25-35 part, Semen Armeniacae Amarum (parched) 7-17 part.
2. the Chinese medicine preparation of the treatment primary pulmonary hypertension according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: 15 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 20 parts, Fructus Psoraleae 15 parts, Concha Haliotidis 30 parts, Concha Ostreae 30 parts, Radix Salviae Miltiorrhizae 20 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Rhizoma Chuanxiong 15 parts, Rhizoma Cyperi 15 parts, Rhizoma Phragmitis 24 parts, Rhizoma Imperatae 24 parts, Radix Aconiti Lateralis Preparata 12 parts, Rhizoma Atractylodis Macrocephalae 24 parts, 20 parts, Poria, Polyporus 18 parts, the Radix Paeoniae Alba 15 parts, Ramulus Cinnamomi 18 parts, Medulla Tetrapanacis 6 parts, Rhizoma Alismatis 15 parts, Radix Cyathulae 18 parts, Semen Coicis 24 parts, the Radix Astragali 30 parts, Semen Armeniacae Amarum (parched) 12 parts.
3. the Chinese medicine preparation for the treatment of primary pulmonary hypertension according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.
4. treat the preparation method of the Chinese medicine preparation of primary pulmonary hypertension for one kind, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, takes Fructus Psoraleae, Semen Coicis bundle becomes medicated bag, be put in water and soak 40-45 minute, for subsequent use, step 2: by weight proportion of the present invention, takes Semen Persicae (parched), Radix Aconiti Lateralis Preparata, Semen Armeniacae Amarum (parched) grinds to 200 mesh sieves, for subsequent use, step 3: by weight proportion of the present invention, take Concha Haliotidis, Concha Ostreae is put into after marmite adds step one immersion and is remained cold water, exceed powder 3-4 centimetre, after being fried boiling with high heat, again with 30-40 minute at a simmer, filter, obtain filtrate, the water of 3-4 centimetre is added in residue medicinal residues, then Radix Salviae Miltiorrhizae is added, Rhizoma Cyperi, Rhizoma Phragmitis, Rhizoma Imperatae, Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Cyathulae, the Radix Astragali decocts 20-30 minute, add Rhizoma Gastrodiae subsequently, Ramulus Uncariae Cum Uncis, Rhizoma Chuanxiong, Poria, Polyporus, Medulla Tetrapanacis, medicated bag in Rhizoma Alismatis and step one, continue to decoct 20-30 minute, finally add Flos Carthami, Ramulus Cinnamomi decocts 10 minutes, filter, obtain filtrate, merge twice filtrate, filter, waste, for subsequent use, step 4: by gained powder Homogeneous phase mixing in step 2 in the medicinal liquid of step 3, both the Chinese medicine decoction for the treatment of primary pulmonary hypertension of the present invention.
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| CN105748762A (en) * | 2016-03-29 | 2016-07-13 | 厦门大学 | Traditional Chinese medicine preparation for treating hypertensive disease and preparation method thereof |
| CN106038997A (en) * | 2016-08-06 | 2016-10-26 | 黑龙江中医药大学 | Traditional Chinese medicine composition for treating idiopathic pulmonary hypertension and preparation method thereof |
| CN106038997B (en) * | 2016-08-06 | 2017-04-19 | 黑龙江中医药大学 | Traditional Chinese medicine composition for treating idiopathic pulmonary hypertension and preparation method thereof |
| CN107753738A (en) * | 2016-08-15 | 2018-03-06 | 石家庄以岭药业股份有限公司 | A kind of application of Chinese medicine composition in the medicine for preparing treatment pulmonary hypertension |
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