CN104873948A - Chinese medicinal preparation for treating artery thrombosis caused by vessel puncture and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicinal preparation for treating artery thrombosis caused by vessel puncture. The Chinese medicinal preparation is prepared from the following materials according to a certain weight ratio: astragalus, angelica, szechuan lovage rhizome, root of red-rooted salvia, Spanish fly, corydalis tuber, spina gleditsiae, medicinal cyathula root, red paeony root, white paeony root, cassia twig, safflower, dried ginger, decumbent corydalis tuber, fried peach kernel, common burreed rhizome, curcuma zedoary, ground beetle, diverse wormwood herb, sappan wood, bark of eucommia, mistletoe, earthworm and herba aristolochiae. The Chinese medicinal preparation has the effects of promoting blood and qi circulation, removing stasis to ease pain, cooling blood and eliminating carbuncle, and can effectively treat the artery thrombosis caused by the vessel puncture.

Description

A kind ofly treat vascular puncture Chinese medicine preparation causing arterial thrombus and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind ofly treat the Chinese medicine preparation that vascular puncture causes arterial thrombus, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Arteriopuncture can do continuous blood pressure monitoring and arterial blood gas sampling, usually for bleeding profusely in vitals transplanting, major trauma, cardiovascular surgery, expectation operation, need repeatedly extracting the operation such as arterial blood gas and hemodynamic instability.Intraarterial pressure is measured through peripheral arterial (being often radial artery) intubate at perioperative, the pressure change of the whole cardiac cycle of Ink vessel transfusing can be recorded, and by transducer, mechanical pressure wave is changed into electronic signal, shield direct display arterial pressure waveform by oscillography through amplifying and marked the numerical value of systolic pressure, diastolic pressure and mean pressure by numeral, and can record continuously, store for analysis and research.Although there is the monitoring of wound arteriotony easy and simple to handle, accurate, responsive, also its complication should be noted at work.

Arterypuncture indwelling intra-arterial catheters causes thromboembolism to be the most serious complication.Radial artery is the most frequently used site of puncture of arterial cannulation, and arterial thrombosis incidence rate is 17%, brachial artery 44%.Hand ischemia is one of RAC most serious consequence causing thromboembolism, and wherein the incidence rate of intubate place far-end skin ischemia is the highest.The downright bad incidence rate in all radial artery intubated patient of metacarpal skin is 0.5 ~ 3%, and the incidence rate in radial artery thrombosis patient is 10%.Angiography and obduction all confirm, when the thrombosis that radial artery intubate causes, radial artery obturation can occur to the perforating branches of skin blood supply.It is relevant that radial artery intubate causes the time of thrombotic incidence rate and inlying catheter and conduit to occupy the percentage ratio of lumen of vessels.Therefore, the general comparatively male of women's tremulous pulse is thin, and the inaccessible incidence rate of its arterial cannulation artery is higher.

At present, vascular puncture is caused to the patient of arterial thrombus, the general method of operation that adopts is treated more, but operative treatment is again once serious injury to the health of patient undoubtedly, and has certain risk, treatment is long for the course for the treatment of, costly, patient not easily accepts, and easily causes the state of an illness to incur loss through delay, expendable damage is caused to the health of patient, brings heavy mental burden and financial burden to relatives and family simultaneously.

Summary of the invention

The object of the present invention is to provide and a kind ofly treat the Chinese medicine preparation that vascular puncture causes arterial thrombus, this Chinese medicine preparation causes arterial thrombus to have good effect for vascular puncture, and cure rate is high, have no side effect, taking convenience, cheap, the feature that healing time is short.Alleviate the misery of patient, for the household of patient and patient alleviates burden and economic pressures at heart.

Another object of the present invention is to provide the preparation method that this treatment vascular puncture causes the Chinese medicine preparation of arterial thrombus.

Inventor is in clinical treatment practice for many years, observe patient's misery in the treatment that vascular puncture causes arterial thrombus, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind ofly to treat the new formula that vascular puncture causes the Chinese medicine preparation of arterial thrombus repeatedly, the present invention selects the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Mylabris, Rhizoma Corydalis, Spina Gleditsiae, Radix Cyathulae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Ramulus Cinnamomi, Flos Carthami, Rhizoma Zingiberis, Rhizoma Corydalis Decumbentis, Semen Persicae (parched), Rhizoma Sparganii, Rhizoma Curcumae, Eupolyphaga Seu Steleophaga, Herba Artemisiae Anomalae, Lignum Sappan, the Cortex Eucommiae, Herba Visci, Pheretima, Herba Aristolochiae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is blood-activating and qi-promoting, stasis-dispelling and pain-killing, effect of removing heat from blood eliminating carbuncle, thus the arterial thrombus that vascular puncture causes can be treated fast and effectively.

The effect of Chinese medicine of the present invention:

Wherein:

The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: tonifying Qi and lifting yang, consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.On the books in " book on Chinese herbal medicine converges and says ": " Radix Astragali, tonifying the lung spleen invigorating defend arresting sweating in fact, and the medicine of wind dispelling fortune poison also.Therefore the people of yang deficiency, spontaneous perspiration frequently comes, be exterior deficiency and interspaces of skin and muscles being loose also, he the Radix Astragali can be defended and arresting sweating in fact; The card of typhoid fever, row is delivered and evil no sweating, and be interior deficiency and also weary in healthy energy, the Radix Astragali can help Tianjin to help antiperspirant; The disease of harmful wind, inclined invasion of vessels and brothers are not with person, and the Radix Astragali can flourish muscles and bones; The card of carbuncle and ulcer, pus and blood internal ulceration, deficiency of YANG QI and do not hold back person, the Radix Astragali can granulation promoting meat, and the erosion of vulva can not rise and send out again, deficiency of YANG QI and unhealed, and the Radix Astragali can granulation promoting meat." this product all has inhibitory action to dysentery bacterium, anthrax bacillus, α-hemolytic streptococcus, beta hemolytic streptococcus, diphtheria corynebacterium, bacillus pseudodiphthericus, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, bacillus subtilis etc. in vitro.Invigorating the spleen and replenishing QI is good at by the Radix Astragali, is the key medicine of tonifying Qi and lifting yang, and QI invigorating diuresis, to subside a swelling.

Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis has inhibitory action to central nervous system, and volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia.For blood deficiency and yellow complexion, dizzy cardiopalmus, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores.Carry according to " book on Chinese herbal medicine is just ": " its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, nothing unsuitable." modern medicine study confirmation, Radix Angelicae Sinensis has antibacterial, antiinflammation.

Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Nature and flavor: pungent, temperature.Return liver, gallbladder, heart channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.The pungent loose temperature of this product is led to, can top, up mountain peak, assigns the sea of blood, outer thorough fur, bypass extremity, can invigorate blood circulation and can circulation of qi promoting, and it is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.Rhizoma Chuanxiong has obvious sedation.The in vitro testses such as antibacterial action: Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Rhizoma Chuanxiong water logging agent (1:3) also has inhibitory action to some pathogenic dermatophytes in vitro.If heart arteries and veins stasis blocking, obstruction of qi in the chest and cardialgia, then normal being equal to Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, is used.This product contains ligustrazine can suppress vascular smooth muscle contraction, coronary artery dilator, increase coronary flow, improve myocardial ischemia situation and Mesentery microcirculation, increase brain and LBF amount, reduce peripheral vascular resistance, can also anticoagulant, can the formation of preventing thrombosis in advance, there is good curative effect to cardiovascular and cerebrovascular disease.

Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia/miltiorrhizaBge.Nature and flavor: bitter, are slightly cold.Gui Jing: enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed.Containing cryptotanshinone, dihydrotanshinone in red sage formulation, there is inhibitory action to external staphylococcus, escherichia coli, degeneration bacillus.Radix Salviae Miltiorrhizae energy blood circulation promoting and blood stasis dispelling, to the hypertrophy eliminating hepatic fibrosis connective tissue, also may have certain effect.Modern medicine experiment proves, Radix Salviae Miltiorrhizae also has anti-platelet aggregation, reduces the function of blood viscosity and the inside and outside blood coagulation system of adjustment, is the natural Chinese medicine that a kind of safety treats again thrombus disease reliably.

Mylabris: this product is the dry body of Meloidae insecticide Mylabris phalarata Mylabris phalerata Pallas or yellow black mylabris cichorii Mylabris cichorii Linnaeus.Nature and flavor: pungent, heat; Very toxic.Return liver, stomach, kidney channel.Effect: removing blood stasis Xiao wei, merit poison phagedenoma, draws red foaming.Yong Yu WEIJIA lump, stubborn dermatitis for many years, scrofula, wart, carbuncle is not burst, the dead flesh of malignant boil." Bencao Jingshu ": Mylabris, person of modern times's muscle then festers, and poison is known.Performance hinders muscle, loses dead flesh, therefore main scrofula cellulitis skin ulcer scabies.Xin Hanneng wanders away down and lets out, therefore the main broken infirmity accumulation of blood of stone and induced abortion are also.The main scrofula of Zhen Quan, tonneau water channel, can chase the intestines and stomach dirt with it greasy, reactivation breaks knot and walks lower orifices also.Mylabris, property is very toxic, and can fester people's muscle, and only scrofula, insane dog sting or can execute temporarily as method, if the sustainability that this thing is forged, still can nibble people's the intestines and stomach, and foaming is festered lethal, if namely the first two card is not also fried with rice is same, get gas and do not use matter to be steady, remaining card must bait.Can be used for disease such as treatment rheumatalgia or neuralgia etc. at present clinically.

Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W. T. Wang.Nature and flavor: acrid, bitter, warm.Return liver, spleen channel.Effect: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.The pungent loose temperature of this product is led to, the stagnation of QI in energy promoting the circulation of blood, stasis in gas, blood-activating and qi-promoting pain relieving, and the kind multiple pain controlled caused by stagnation of QI and blood, its analgesic effect is excellent.Record in " book on Chinese herbal medicine is looked for the truth ": Rhizoma Corydalis, no matter being blood is gas, amass and loose person, taking this power can be sensible, warm in nature with it, then can manage it in QI and blood can be smooth, and acrid in the mouth then can moisten can fall apart in QI and blood, so manage upper and lower all pains all over the body, merit of often walking alone is many.

Spina Gleditsiae: be the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Nature and flavor: pungent, temperature.Return lung, Liver Channel.Effect: detumescence and apocenosis, promoting blood circulation by removing wind.Tcm clinical practice is used for swollen ulcer drug all good therapeutic effect, generally shows as the non-Cheng Zheke of pus and disappears, and formed pus person can make it speed and burst.Modern anticancer pharmacological research shows, Spina Gleditsiae has anticancer tumor-suppression activity.Modern pharmacology is studied its decoct flat board and to be burrowed method, has inhibitory action to staphylococcus aureus and micrococcus catarrhalis.It is up that Spina Gleditsiae can draw all medicines, the kind disease controlling the part of the body cavity above the diaphragm housing the heart and lungs.

Radix Cyathulae: be the dry root of amaranthaceous plant Radix Cyathulae Cyathula officinalis Kuan.Nature and flavor: sweet, micro-hardship, flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.

Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Nature and flavor: bitter, are slightly cold.Return Liver Channel.Effect: eliminating stasis to stop pain, clearing away heat and cooling blood, detumescence.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.This product hardship is fallen, and has effect of promoting blood circulation to restore menstrual flow, loose Yu Xiao wei, row stagnation pain.Often join Cortex Moutan.For the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, this product bitter cold, main enter Liver Channel, be apt to away blood system, can clearing away liver-fire, except blood system is hot and suffocating and have the merit of removing heat from blood, hemostasis, dissipating blood stasis speckle removing.

The Radix Paeoniae Alba: be the dry root of dicotyledon ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: cool, picric acid, is slightly cold.Effect: easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receives antiperspirant.Research shows: the paeoniflorin contained in the Radix Paeoniae Alba has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.This product energy nourishing the liver blood, holding back liver-yin, subduing the hyperfunction of the liver sun, dispersing liver-energy, can delay again that contraction is anxious, relieve the pain pain, is the good medicine of the various pain for the treatment of Liver Channel.

Ramulus Cinnamomi: be the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor: acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Ramulus Cinnamomi is usually used in treating phlegm retention, syndrome of water-retention, and water belongs with yin is evil, and obtain positive beginningizations, Ramulus Cinnamomi enters urinary bladder channel, energy warming YANG activating QI, with the heresy of row water damp-phlegm drink, with the phlegm retention syndrome controlled spleen sun and do not transport, is often equal to Poria, the Rhizoma Atractylodis Macrocephalae and uses.Ramulus Cinnamomi is warm in nature, and the kind gas that activates yang, can change YIN-cold, hold back resistance yang-energy to YIN-cold, and body fluid can not defeated cloth, the thus disease of retention of water-damp formation phlegm retention.This product energy promoting the flow of QI-blood by warming the meridian, dispersing cold for relieving pain, for all pain cards such as congealing cold with blood stasis.

Flos Carthami: be the tubular corolla of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: temperature, pungent.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.The pungent loose temperature of Flos Carthami is led to, and specially enters blood system, can blood circulation promoting and blood stasis dispelling, and stimulate the menstrual flow pulse-taking, and the mutual reinforcements between such as normal and Semen Persicae, Radix Angelicae Sinensis, Rhizoma Chuanxiong are for use.Flos Carthami has blood vessel dilating effect.Carthamus yellow can obviously extend blood plasma recalcification time, prothrombin time and clotting time." Amplification on Materia Medica addendum ": " Flos Carthami, broken stagnant blood, nourishes blood.Multiplex then removing blood stasis is few with then nourishing blood." crude extract from carthamus tinctorius L. with water has slight excited heart, increases the effect of coronary flow, have myocardial ischemia and alleviate effect, and make decreased heart rate, the amplitude that electrocardiogram S-T section is raised significantly declines, and also has anticoagulant and increases fibrinolysis activity.

Rhizoma Zingiberis: be the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: pungent, hot.Return spleen, stomach, the heart, lung meridian.Effect: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.The pyogenic infection of Rhizoma Zingiberis external curing wound.This product hot dry strong, main enter taste warp, be longer than warm middle burnt spleen sun and cold expelling, therefore all middle burnt cold syndrome, the excess-cold syndrome of no matter invading in exogenous cold, or the deficiency-cold syndrome of YANG QI deficiency, be key medicine.

Rhizoma Corydalis Decumbentis: be the dry tuber of bloodroot Hotseason grow Corydalis decumbens (Thunb.) Pers..Nature and flavor: bitter, micro-pungent, temperature.Return Liver Channel.Effect: promoting blood circulation to remove obstruction in the collateral, promoting the circulation of QI to relieve pain.For apoplectic hemiplegia, injury from falling down, rheumatic arthritis, sciatica.This product has blood pressure lowering, calmness, the effect such as relaxing muscles and tendons, active, pain relieving.

Semen Persicae (parched): be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.The power of Semen Persicae blood stasis dispelling is comparatively strong, also known as stasis-breaking drug, is used for the treatment of blood stasis, WEIJIA, often joins Flos Carthami, Radix Angelicae Sinensis.Semen Persicae is improved effect to blood flow retardance, blood obstacle, and each internal organs can be made respectively to organize functional recovery normal.

Rhizoma Sparganii: be the dry tuber of Sparganiaceae plant Rhizoma Sparganii Spaganium stoloniferum Buch.-Ham..Nature and flavor: pungent, puckery, cool.Enter liver, spleen channel.Effect: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Lump in the abdomen controlled by Chinese medicine, gathers, distending pain over the hypochondrium, food stagnation distending pain, dysmenorrhea, amenorrhea, and postnatal blood stasis is suffered from abdominal pain, traumatic injury.Pharmaceutical research: Rhizoma Sparganii has anticoagulant, extends thrombus formation time, shortens thrombosis, the effect of length and weight reduction, also has the trend extending prothrombin time and part Thrombokinase, reduces whole blood viscosity.

Rhizoma Curcumae: be monocotyledon Zingiberaceae Zingiberaceae Rhizoma Curcumae Curcuma phaeocaulis Val., or RADIX CURCUMAE (also known as Curcuma wenyujin) C. wenyujin Y. H. Chen et C. Ling, the dry rhizome of Guangxi zedoary (also known as C. kwangsinensis) C.kwangsiensis S. lee et C. F. Liang.Nature and flavor: pungent, bitter, temperature.Return liver, spleen channel.Effect: removing blood stasis, promoting the circulation of QI to relieve pain.Often join Rhizoma Sparganii.Antibacterial action: Rhizoma Curcumae volatile oil in vitro can suppress staphylococcus aureus.The growth of beta hemolytic streptococcus, escherichia coli, Bacillus typhi, vibrio cholera etc.Rhizoma Curcumae has the effect of directly killing oncocyte.Pharmaceutical research, Rhizoma Curcumae has certain effect to cardiovascular, and it is the most obvious that Rhizoma Curcumae increases acting in drug for invigorating blood circulation and eliminating stasis of femoral artery blood flow, and Rhizoma Curcumae also has suppression platelet aggregation and antithrombotic effect.

Eupolyphaga Seu Steleophaga: for the female worm of Corydiidae insecticide eupolyphoge sinensis Eupolyphaga sinensis Walker or Ji eupolyphoge sinensis Stelephaga plancyi (Boleny) is all.Nature and flavor: cold, salty; Slightly poisonous.Return Liver Channel.Effect: removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones, is used for the treatment of traumatic injury, and the injury of tendon and muscle is fractured, pain caused by ecchymoma.This product salty-cold enter blood, main enter Liver Channel, property is apt to away alter, can promoting blood circulation and detumescence pain relieving, and reunion of fractured tendons and bones is cured the wound, and is traumatology common medicine, is especially used for the injury of tendon and muscle of fracturing, swelling and pain due to blood stasis.

Herba Artemisiae Anomalae: be the wounded in the battle herb of feverfew artemisia anomalas (Herba Artemisiae Anomalae).Nature and flavor: acrid in the mouth; Micro-hardship; Warm in nature.GUIXIN; Liver; Spleen channel.Effect: dissipating blood stasis to promote menstruationg; Hemostasia and detumescence; Promoting digestion and removing stagnation.For amenorrhea, dysmenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lochiorrhea, lump in the abdomen; Traumatic injury; Incised wound is hemorrhage; Rheumatic arthralgia; Have blood in stool; Hematuria; Carbuncle pyogenic infections from tumour or sore; Scald; Abdominal pain due to retention of food; Dysentery.

Lignum Sappan: be the dry duramen of leguminous plant Lignum Sappan (Caesalpinia sappanL.).Nature and flavor are sweet, salty, pungent, cool.GUIXIN; Liver; Stomach; Spleen channel.Effect: blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.

The Cortex Eucommiae: be the dry bark of the Eucommiaceae plant Cortex Eucommiae (Eucommia ulmoides Oliver).Nature and flavor: sweet, temperature.Return liver, kidney, stomach warp.Effect: liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, solid through antiabortive.Compendium of Material Medica: the Cortex Eucommiae, ancient prescription only knows nourishing kidney, and only Wang Haogu speech is Liver Channel edema caused by disorder of QI medicine, and profit liver is dry, and tonifying liver is empty, sends out former times people and does not send out also.Lid liver governing tendons, kidney governing bones, it is strong that kidney fills then bone, and liver is filled then muscle and is good for, and bends and stretches utilization, all belongs to muscle.

Herba Visci: be the dry stem and branch with leaf of Loranthaceae plant Herba Visci Viscum coloratum (Komar.) Nakai.Nature and flavor: bitter are flat.Return liver, kidney channel.Effect: wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For rheumatic arthralgia, soreness of the waist and knees, frequent fetal movement.

Pheretima: be the dry body of Ju Yin section animal Pheretima aspergillum Pheretima aspergillum (E. Perrier), popular Pheretimatschiliensis Pheretima vulgaris Chen, power simulation Pheretima guillelmi (Michaelsen) or comb blind Pheretimatschiliensis Pheretima pectinifera Michaelsen.Nature and flavor: salty, cold.Return liver, spleen, urinary bladder channel.Effect: heat clearing away is calmed the frightened, dredge the meridian passage, clearing heat and relieving dyspnea, relieving stranguria by diuresis.

Herba Aristolochiae: be the dry aerial parts of aristolochiaceae plant Fructus Aristolochiae Aristolochia debilis Sieb. et Zucc. or Aristolochia contorta Aristolochia contorta Bunge..Nature and flavor: bitter, temperature.Return liver,spleen,kidney warp.Effect: promoting flow of QI and blood, inducing diuresis to remove edema.For gastral cavity ventral spine pain, arthralgia, edema during pregnancy." book on Chinese herbal medicine is looked for the truth ": Herba Aristolochiae, see book discuss and cure mainly, only belong to the diseases such as pregnant edema during pregnancy, stomachache, wind consumptive disease, in his disease then not and here.Its reason controlled i.e., also only because bitter in the mouth master is in catharsis, warm in nature being led to lives, therefore passage of invigorating blood circulation, and makes water without unfavorable, and wind removes invariably, blood work invariably, and pain to be controlled therefore also all invariably with swollen.

Side's solution of the present invention is: Radix Astragali inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer in side, Radix Angelicae Sinensis, Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping, Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, Mylabris removing blood stasis Xiao wei, Rhizoma Corydalis blood circulation promoting regulates qi, above Six-element is monarch drug altogether, monarch drug not only carries out blood circulation promoting and blood stasis dispelling, blood circulation promoting regulates qi from basic focus, fundamentally can also carry out clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind from health, fundamentally the health of patient be nursed one's health, reach the object for the treatment of both the principal and secondary aspects of a disease.Spina Gleditsiae detumescence and apocenosis, promoting blood circulation by removing wind, Radix Cyathulae eliminating blood stasis and inducing menstruation, Radix Paeoniae Rubra, Radix Paeoniae Alba eliminating stasis to stop pain, Ramulus Cinnamomi warming the meridian and promoting blood circulation, supporing yang activating QI, Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, above seven tastes are ministerial drug altogether, principal drug assistance eliminating thrombus and removing obstruction in channels, promoting the flow of QI-blood by warming the meridian.Supporing yang activating QI is conducive to the flowing promoting blood, reduces the formation again of thrombosis.Rhizoma Corydalis Decumbentis promoting blood circulation to remove obstruction in the collateral, promoting the circulation of QI to relieve pain, Semen Persicae (parched) blood circulation promoting and blood stasis dispelling, Rhizoma Sparganii, Rhizoma Curcumae removing blood stasis, promoting the circulation of QI to relieve pain, Eupolyphaga Seu Steleophaga removing blood stasis with potent drugs blood, Herba Artemisiae Anomalae dissipating blood stasis to promote menstruationg, Lignum Sappan blood circulation promoting and blood stasis dispelling, Cortex Eucommiae Chong and Ren Meridians regulating, solid through antiabortive, Herba Visci wind-damp dispelling, invigorating the liver and kidney, Pheretima dredge the meridian passage, Herba Aristolochiae promoting flow of QI and blood, inducing diuresis to remove edema, a few taste is adjuvant drug altogether above, increase curative effect of medication, promote drug absorption, accelerate the improvement of the state of an illness.All medicine compatibilities in side, the monarch and his subjects pull together, help and make auxiliary altogether, make it the effect with blood-activating and qi-promoting, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, can effectively treat vascular puncture and cause arterial thrombus.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Astragali 25-35 part, Radix Angelicae Sinensis 13-23 part, Rhizoma Chuanxiong 7-17 part, Radix Salviae Miltiorrhizae 15-25 part, Mylabris 3-9 part, Rhizoma Corydalis 19-29 part, Spina Gleditsiae 19-29 part, Radix Cyathulae 13-23 part, Radix Paeoniae Rubra 7-17 part, Radix Paeoniae Alba 10-20 part, Ramulus Cinnamomi 10-20 part, Flos Carthami 4-14 part, Rhizoma Zingiberis 19-29 part, Rhizoma Corydalis Decumbentis 7-17 part, Semen Persicae (parched) 7-17 part, Rhizoma Sparganii 10-20 part, Rhizoma Curcumae 10-20 part, Eupolyphaga Seu Steleophaga 4-14 part, Herba Artemisiae Anomalae 19-29 part, Lignum Sappan 7-17 part, Cortex Eucommiae 15-25 part, Herba Visci 13-23 part, Pheretima 4-14 part, Herba Aristolochiae 15-25 part.

Wherein be preferably: the Radix Astragali 30 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 12 parts, Radix Salviae Miltiorrhizae 20 parts, Mylabris 6 parts, Rhizoma Corydalis 24 parts, Spina Gleditsiae 24 parts, Radix Cyathulae 18 parts, Radix Paeoniae Rubra 12 parts, the Radix Paeoniae Alba 15 parts, Ramulus Cinnamomi 15 parts, 9 parts, Flos Carthami, Rhizoma Zingiberis 24 parts, Rhizoma Corydalis Decumbentis 12 parts, Semen Persicae (parched) 12 parts, Rhizoma Sparganii 15 parts, Rhizoma Curcumae 15 parts, Eupolyphaga Seu Steleophaga 9 parts, Herba Artemisiae Anomalae 24 parts, Lignum Sappan 12 parts, the Cortex Eucommiae 20 parts, Herba Visci 18 parts, Pheretima 9 parts, Herba Aristolochiae 20 parts.

Medicine of the present invention can adopt the conventional fabrication process of Chinese medicine preparation, can be made into said dosage form on any one pharmaceutics, as pill, powder, tablet, capsule, granule, syrup, oral liquid etc.Such as can by these crude drug grinds into fine powder, granularity is 80-120 order, gained fine powder is dropped into hybrid medicine blender and fully mixes, make powder warm water and take after mixing it with water.Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.

The preferred preparation method of the present invention is granule, and its preparation method is as follows:

Step one: by weight proportion of the present invention, takes Semen Persicae (parched) drying and crushing to 180 mesh sieve, for subsequent use;

Step 2: by weight proportion of the present invention, takes Mylabris, Eupolyphaga Seu Steleophaga, Pheretima is air-dry is crushed to 180 mesh sieves, for subsequent use;

Step 3: by weight proportion of the present invention, take the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Cyathulae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Rhizoma Zingiberis, Lignum Sappan, the Cortex Eucommiae puts into marmite, add the water of 2-3 centimetre, after being fried boiling with high heat, again with 30-40 minute at a simmer, filter, obtain filtrate, the water of 3-4 centimetre is added in residue medicinal residues, then Radix Angelicae Sinensis is added, Rhizoma Chuanxiong, Rhizoma Corydalis, Spina Gleditsiae, Rhizoma Corydalis Decumbentis, Rhizoma Sparganii, Rhizoma Curcumae, Herba Artemisiae Anomalae, Herba Visci, Herba Aristolochiae decocts 20 minutes, finally add Ramulus Cinnamomi, Flos Carthami decocts 10 minutes, filter, obtain filtrate, merge twice filtrate, when gained filtrate is concentrated into 70-85 DEG C, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, the clear paste of relative density 1.13 ~ 1.18 under 70 DEG C of environment, for subsequent use,

Step 4: step one, step 2 gained fine powder are added in clear paste and is uniformly mixed, dry, be ground into fine powder, add appropriate lactose as diluent, ethanol as wetting agent and microcrystalline Cellulose as disintegrating agent, adopt dry granulation, make 15g/ bag, every bag of granule containing crude drug 5g.

Medicine of the present invention has effect of blood-activating and qi-promoting, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, and good effect, cure rate is high, has no side effect, taking convenience, cheap, healing time is short, and the mode that this Chinese medicine preparation adopts is treated and can be reduced Western medicine and the injury caused patient of performing the operation, and adds up according to clinical 180 routine patient view, use medicine of the present invention the total effective rate course for the treatment of 90%, two the total effective rate course for the treatment of 95%.

Detailed description of the invention

Embodiment one, the Radix Astragali 25 parts, Radix Angelicae Sinensis 13 parts, Rhizoma Chuanxiong 7 parts, Radix Salviae Miltiorrhizae 15 parts, Mylabris 3 parts, Rhizoma Corydalis 19 parts, Spina Gleditsiae 19 parts, Radix Cyathulae 13 parts, Radix Paeoniae Rubra 7 parts, the Radix Paeoniae Alba 10 parts, Ramulus Cinnamomi 10 parts, 4 parts, Flos Carthami, Rhizoma Zingiberis 19 parts, Rhizoma Corydalis Decumbentis 7 parts, Semen Persicae (parched) 7 parts, Rhizoma Sparganii 10 parts, Rhizoma Curcumae 10 parts, Eupolyphaga Seu Steleophaga 4 parts, Herba Artemisiae Anomalae 19 parts, Lignum Sappan 7 parts, the Cortex Eucommiae 15 parts, Herba Visci 13 parts, Pheretima 4 parts, Herba Aristolochiae 15 parts.

Embodiment two, the Radix Astragali 30 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 12 parts, Radix Salviae Miltiorrhizae 20 parts, Mylabris 6 parts, Rhizoma Corydalis 24 parts, Spina Gleditsiae 24 parts, Radix Cyathulae 18 parts, Radix Paeoniae Rubra 12 parts, the Radix Paeoniae Alba 15 parts, Ramulus Cinnamomi 15 parts, 9 parts, Flos Carthami, Rhizoma Zingiberis 24 parts, Rhizoma Corydalis Decumbentis 12 parts, Semen Persicae (parched) 12 parts, Rhizoma Sparganii 15 parts, Rhizoma Curcumae 15 parts, Eupolyphaga Seu Steleophaga 9 parts, Herba Artemisiae Anomalae 24 parts, Lignum Sappan 12 parts, the Cortex Eucommiae 20 parts, Herba Visci 18 parts, Pheretima 9 parts, Herba Aristolochiae 20 parts.

Embodiment three, the Radix Astragali 35 parts, Radix Angelicae Sinensis 23 parts, Rhizoma Chuanxiong 17 parts, Radix Salviae Miltiorrhizae 25 parts, Mylabris 9 parts, Rhizoma Corydalis 29 parts, Spina Gleditsiae 29 parts, Radix Cyathulae 23 parts, Radix Paeoniae Rubra 17 parts, the Radix Paeoniae Alba 20 parts, Ramulus Cinnamomi 20 parts, 14 parts, Flos Carthami, Rhizoma Zingiberis 29 parts, Rhizoma Corydalis Decumbentis 17 parts, Semen Persicae (parched) 17 parts, Rhizoma Sparganii 20 parts, Rhizoma Curcumae 20 parts, Eupolyphaga Seu Steleophaga 14 parts, Herba Artemisiae Anomalae 29 parts, Lignum Sappan 17 parts, the Cortex Eucommiae 25 parts, Herba Visci 23 parts, Pheretima 14 parts, Herba Aristolochiae 25 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept vascular puncture for medical treatment and cause arterial thrombus patient 360 example.Patient is divided into observation group and matched group at random, wherein male 187 example, women 173 example, M-F 1.1:1, every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).

Two, Therapeutic Method:

1, according to Medications Example two of the present invention, and granule prepared by preferred preparation method, one day three times, each one bag, decoction being taken warmly.It within 7th, is a course for the treatment of.

2, matched group causes the method for arterial thrombus to treat according to routine of western medicine improvement vascular puncture, and the observation period is 7 days.

Three, efficacy assessment standard:

1, cure: patients symptomatic, sign disappear, ultrasound wave display thrombosis disappearance, blood flow, flow restoration are normal;

2, take a turn for the better: symptom disappears substantially, and sign is clearly better, and thrombosis obviously reduces;

3, do not heal: symptom, sign are without any improvement, ultrasound wave display thrombosis is without significant change.

Four, observation group's result statistics

Matched group result is added up

Wherein: total effective rate=cure rate+improvement rate

Take the Comparison of therapeutic situation of two groups of patients, two courses for the treatment of

Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention causes arterial thrombus to have good clinical effectiveness at treatment vascular puncture, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.

Model case and curative effect:

Case one, Zhang, female, 60 years old, patient causes arterial thrombus when doing vascular puncture, because female patient blood vessel is thinner, after there is thrombosis in patient, stopped vascular puncture procedures immediately, because patient age is larger, wish the method adopting expectant treatment, made granule in the rear employing embodiment of the present invention two, take patient's pain after two courses for the treatment of, swelling phenomenon alleviates, color ultrasound examination display thrombosis reduces, blood viscosity reduces, continue to take medicine after two courses for the treatment of, the clinical symptoms of patient's arterial thrombus disappears completely, color ultrasound examination has no thrombosis, recovery from illness, continuous observation had no recurrence after one week.

Case two, Wu, man, 48 years old, patient is the complications causing arterial thrombus at vascular puncture, and patient adopts made granule in the invention process case two, and after taking three courses for the treatment of, patient's clinical symptoms obviously alleviates, patient holds on and takes a period of time, ultrasound investigation display thrombosis disappears, and recovery from illness, continuous observation had no recurrence after one week.

Case three, fourth, female, 52 years old, cause the complication such as arterial thrombus when patient vessel punctures, patient does not wish to adopt conservative Therapeutic Method, and patient adopts made granule in the invention process case two, after taking a course for the treatment of, patient's clinical symptoms obviously alleviates, for preventing recurrence, patient adheres to again having taken two courses for the treatment of, ultrasound investigation, thrombosis fades away, continuous observation about one week, has no recurrence, recovery from illness.

Claims (4)

1. treat the Chinese medicine preparation that vascular puncture causes arterial thrombus for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Astragali 25-35 part, Radix Angelicae Sinensis 13-23 part, Rhizoma Chuanxiong 7-17 part, Radix Salviae Miltiorrhizae 15-25 part, Mylabris 3-9 part, Rhizoma Corydalis 19-29 part, Spina Gleditsiae 19-29 part, Radix Cyathulae 13-23 part, Radix Paeoniae Rubra 7-17 part, Radix Paeoniae Alba 10-20 part, Ramulus Cinnamomi 10-20 part, Flos Carthami 4-14 part, Rhizoma Zingiberis 19-29 part, Rhizoma Corydalis Decumbentis 7-17 part, Semen Persicae (parched) 7-17 part, Rhizoma Sparganii 10-20 part, Rhizoma Curcumae 10-20 part, Eupolyphaga Seu Steleophaga 4-14 part, Herba Artemisiae Anomalae 19-29 part, Lignum Sappan 7-17 part, Cortex Eucommiae 15-25 part, Herba Visci 13-23 part, Pheretima 4-14 part, Herba Aristolochiae 15-25 part.

2. treatment vascular puncture according to claim 1 causes the Chinese medicine preparation of arterial thrombus, it is characterized in that, be made up of the medicine of following weight portion: the Radix Astragali 30 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 12 parts, Radix Salviae Miltiorrhizae 20 parts, Mylabris 6 parts, Rhizoma Corydalis 24 parts, Spina Gleditsiae 24 parts, Radix Cyathulae 18 parts, Radix Paeoniae Rubra 12 parts, the Radix Paeoniae Alba 15 parts, Ramulus Cinnamomi 15 parts, 9 parts, Flos Carthami, Rhizoma Zingiberis 24 parts, Rhizoma Corydalis Decumbentis 12 parts, Semen Persicae (parched) 12 parts, Rhizoma Sparganii 15 parts, Rhizoma Curcumae 15 parts, Eupolyphaga Seu Steleophaga 9 parts, Herba Artemisiae Anomalae 24 parts, Lignum Sappan 12 parts, the Cortex Eucommiae 20 parts, Herba Visci 18 parts, Pheretima 9 parts, Herba Aristolochiae 20 parts.

3. treatment vascular puncture according to claim 1 and 2 causes the Chinese medicine preparation of arterial thrombus, it is characterized in that: described Chinese medicine preparation is granule.

4. treatment vascular puncture according to claim 3 causes the Chinese medicine preparation of arterial thrombus, and its preparation method is as follows: step one: by weight proportion of the present invention, takes Semen Persicae (parched) drying and crushing to 180 mesh sieve, for subsequent use, step 2: by weight proportion of the present invention, takes Mylabris, Eupolyphaga Seu Steleophaga, Pheretima is air-dry is crushed to 180 mesh sieves, for subsequent use, step 3: by weight proportion of the present invention, take the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Cyathulae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Rhizoma Zingiberis, Lignum Sappan, the Cortex Eucommiae puts into marmite, add the water of 2-3 centimetre, after being fried boiling with high heat, again with 30-40 minute at a simmer, filter, obtain filtrate, the water of 3-4 centimetre is added in residue medicinal residues, then Radix Angelicae Sinensis is added, Rhizoma Chuanxiong, Rhizoma Corydalis, Spina Gleditsiae, Rhizoma Corydalis Decumbentis, Rhizoma Sparganii, Rhizoma Curcumae, Herba Artemisiae Anomalae, Herba Visci, Herba Aristolochiae decocts 20 minutes, finally add Ramulus Cinnamomi, Flos Carthami decocts 10 minutes, filter, obtain filtrate, merge twice filtrate, when gained filtrate is concentrated into 70-85 DEG C, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, the clear paste of relative density 1.13 ~ 1.18 under 70 DEG C of environment, for subsequent use, step 4: step one, step 2 gained fine powder are added in clear paste and is uniformly mixed, dry, be ground into fine powder, add appropriate lactose as diluent, ethanol as wetting agent and microcrystalline Cellulose as disintegrating agent, adopt dry granulation, make 15g/ bag, every bag of granule containing crude drug 5g.