CN104721802A - TCM (traditional Chinese medicine) preparation for treating constrictive pericarditis and preparing method thereof - Google Patents

Abstract

The invention discloses a TCM (traditional Chinese medicine) preparation for treating constrictive pericarditis. The TCM preparation comprises, according to a certain weight ratio, Astragalus root, heterophylly falsestarwort root, fried white atractylodes rhizome, Indian bread, Rhodiolae root, fried peach kernel, safflower, Szechuan lovage rhizome, prepared rehmannia root, dogwood, nutgrass galingale rhizome, Chinese angelica, root of common peony, root of red-rooted salvia, corydalis tuber, Chinese thorowax root, bitter orange, Turmeric root-tuber, sappan wood, cassia twig, snake gourd fruit, longstamen onion bulb, dried ginger and Manchurian wild ginger. The TCM preparation has the effects of tonifying qi and lifting yang, promoting intelligence and nourishing heart, clearing damp and promoting diuresis and eliminating stasis to subdue swelling and has the effect of treating constrictive pericarditis.

Description

A kind of Chinese medicine preparation for the treatment of constrictive pericarditis and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of constrictive pericarditis.The invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Constrictive pericarditis is due to pericardium pericardial thickening that chronic inflammatory disease causes, adhesion even calcification, and make diastole, shrink limited, Heart function fails, causes the disease of systemic blood circulation obstacle most caused by tuberculous pericarditis.Acute suppurative pericarditis protracted course of disease person accounts for 10%, and other also can be caused by rheumatism, wound, mediastinal irradiation etc.Early stage execution pericardiectomy can be avoided developing into cardiac cachexia, serious hepatic insufficiency, myocardial atrophy etc.Actively prevent and treat acute pericarditis can avoid being developed to pericardium constriction.The pericardium constraint heart generally thickened, there is the signs such as distension of jugular vein, hepatomegaly, ascites, hydrothorax in each internal organs congestion of whole body.Within 3 ~ 6 months, symptom can be there is in tuberculous pericarditis at After acute stage.Common are tired, breathe hard, oliguria, abdominal distention, loss of appetite, ascites, hepatomegaly be cause hydrosarca person, dyspnea increases the weight of.Electrocardiogram, ultrasoundcardiogram, x-ray right cardiac catheterization is diagnosable.

At present for the method mainly early operation of constrictive pericarditis treatment, although operation has certain curative effect, but be generally for early stage patient successful, if operation prognosis nursing is improper, also can bring larger injury to patient, bring larger burden also can to economically the family of patient, patient is beyond affordability.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation, it is good that this Chinese medicine preparation has therapeutic effect for treatment constrictive pericarditis, and not easily recur, cheap, healing time is short, the feature of taking convenience.

Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment constrictive pericarditis.

Inventor is in clinical treatment practice for many years, observe the misery that constrictive pericarditis brings to patient, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of constrictive pericarditis repeatedly, the present invention selects the Radix Astragali, Radix Pseudostellariae, Rhizoma Atractylodis Macrocephalae (parched), Poria, Radix Rhodiolae, Semen Persicae (parched), Flos Carthami, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Fructus Corni, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Rhizoma Corydalis, Radix Bupleuri, Fructus Aurantii, Radix Curcumae, Radix Platycodonis, Lignum Sappan, Ramulus Cinnamomi, Fructus Trichosanthis, Bulbus Allii Macrostemonis, Rhizoma Zingiberis, Herba Asari combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is tonifying Qi and lifting yang, Fructus Alpiniae Oxyphyllae is nourished heart, promoting diuresis to eliminate damp pathogen, effect of dissipating blood stasis for subsidence of swelling, thus effectively can treat constrictive pericarditis.

The effect of Chinese medicine of the present invention:

Wherein:

The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: tonifying Qi and lifting yang, consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.On the books in " book on Chinese herbal medicine converges and says ": " Radix Astragali, tonifying the lung spleen invigorating defend arresting sweating in fact, and the medicine of wind dispelling fortune poison also.Therefore the people of yang deficiency, spontaneous perspiration frequently comes, be exterior deficiency and interspaces of skin and muscles being loose also, he the Radix Astragali can be defended and arresting sweating in fact; The card of typhoid fever, row is delivered and evil no sweating, and be interior deficiency and also weary in healthy energy, the Radix Astragali can help Tianjin to help antiperspirant; The disease of harmful wind, inclined invasion of vessels and brothers are not with person, and the Radix Astragali can flourish muscles and bones; The card of carbuncle and ulcer, pus and blood internal ulceration, deficiency of YANG QI and do not hold back person, the Radix Astragali can granulation promoting meat, and the erosion of vulva can not rise and send out again, deficiency of YANG QI and unhealed, and the Radix Astragali can granulation promoting meat." invigorating the spleen and replenishing QI is good at by the Radix Astragali, is the key medicine of tonifying Qi and lifting yang, and QI invigorating diuresis, to subside a swelling.

Radix Pseudostellariae: for Caryophyllaceae Radix Pseudostellariae belongs to the dry root of (Pseudostellaria) plant Radix Pseudostellariae.Nature and flavor: sweet, micro-hardship, tepor.Return lung, spleen channel.Effect: mend strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus, palpitation with a distress feeling, edema, quenches one's thirst, metal fatigue.Radix Pseudostellariae joins the Radix Astragali, and the effect of tonification increases, and conventional to control overstrain weak be effect.Tcm clinical practice uses widely.Generally have xerostomia, agitation, cardiopalmus, insomnia, patient that is weak, the deficiency of both QI and YIN symptom such as lack of appetite, feverish sensation in the palms and soles all can use.The Radix Pseudostellariae property of medicine is very steady, and applicable chronic patient is taken for a long time in a large number, empty and be unable to bear that to nourish medicine high benefit people be best selection for those bodies, and can not cause elevation of the blood pressure, the symptom such as to get angry.

Rhizoma Atractylodis Macrocephalae (parched): be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, the Rhizoma Atractylodis Macrocephalae can air making-up and spleen enlivening, again can dampness diuretic, is the key medicine of the spleen strengthening and damp drying.In the sweet temperature compensation of the Rhizoma Atractylodis Macrocephalae, can air making-up and spleen enlivening, also can strengthening superficial resistance to stop perspiration, and the Radix Astragali, Radix Pseudostellariae compatibility, play the merit of spleen reinforcing lung altogether.To rule together asthenia, the weak person of overstrain.

Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, is the key medicine of promoting diuresis to eliminate damp pathogen.Poria decoct has obvious sedation." modality ": " cure mainly Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side." this product is by heart-spleen boosting and tranquilizing mind.Be used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.

Radix Rhodiolae: be Crassulaceae Rhodida plant Radix Rhodiolae Rhodiola saera (Prain) Fu, with all herbal medicine.Nature and flavor: sweet, puckery, cold.Effect: QI invigorating lung heat clearing; Fructus Alpiniae Oxyphyllae is nourished heart; Hemostasis with astringents; Dissipating blood stasis for subsidence of swelling.Main deficiency of vital energy and physically weak; Fear of cold after being ill; Shortness of breath and fatigue; Cough due to lung-heat; Spitting of blood; Leucorrhea is suffered from diarrhoea; Traumatic injury; Burn and scald; Neurosis; Altitude sickness.

Semen Persicae (parched): be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.The power of Semen Persicae blood stasis dispelling is comparatively strong, also known as stasis-breaking drug, is used for the treatment of blood stasis, WEIJIA, often joins Flos Carthami, Radix Angelicae Sinensis.Semen Persicae is improved effect to blood flow retardance, blood obstacle, and each internal organs can be made respectively to organize functional recovery normal.

Flos Carthami: be the tubular corolla of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: temperature, pungent.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.The mutual reinforcements between such as the pungent loose temperature of Flos Carthami is led to, and specially enters blood system, can blood circulation promoting and blood stasis dispelling, and stimulate the menstrual flow pulse-taking, normal and Semen Persicae are for use.Flos Carthami has blood vessel dilating effect.Crude extract from carthamus tinctorius L. with water has slight excited heart, increases the effect of coronary flow, and have myocardial ischemia and alleviate effect, and make decreased heart rate, the amplitude that electrocardiogram S-T section is raised significantly declines, and also has anticoagulant and increases fibrinolysis activity.

Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Nature and flavor: pungent, temperature.Return liver, gallbladder, heart channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.The pungent loose temperature of this product is led to, can top, up mountain peak, assigns the sea of blood, outer thorough fur, bypass extremity, can invigorate blood circulation and can circulation of qi promoting, and it is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.Rhizoma Chuanxiong has obvious sedation.The in vitro testses such as antibacterial action: Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Rhizoma Chuanxiong water logging agent (1:3) also has inhibitory action to some pathogenic dermatophytes in vitro.This product contains ligustrazine can suppress vascular smooth muscle contraction, coronary artery dilator, increase coronary flow, improve myocardial ischemia situation and Mesentery microcirculation, increase brain and LBF amount, reduce peripheral vascular resistance, can also anticoagulant, can the formation of preventing thrombosis in advance, there is good curative effect to cardiovascular and cerebrovascular disease.

Radix Rehmanniae Preparata: be scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa(Gdertn) Iibosch.ex Fisch. et Mey.) tuber form through Processing methods.Nature and flavor: sweet, tepor.Return liver, kidney channel.Effect: nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.Radix Rehmanniae Preparata can be enriched blood YIN nourishing and liver-nourishing kidney-boosting, and all blood deficiency the moon loses, dizzy caused by deficiency of the liver and kindey, all can apply.In addition, as joined the product such as Radix Pseudostellariae Poria, can be used for cardiopalmus, insomnia.

Fructus Corni: be the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb. et Zucc..Nature and flavor: sour, puckery, tepor.Return liver, kidney channel.Effect: liver and kidney tonifying, essence astringing and desertion stemming.Cure mainly and have a dizzy spell, deafness and tinnitus, soreness of the waist and knees, emission and spermatorrhea, frequent micturition, incessant sweating due to debility, woman uterine bleeding.

Rhizoma Cyperi: be the dry rhizome of sedge dried tuber Cyperus rotundus L..Nature and flavor: pungent, micro-hardship, micro-sweet are flat.Return liver, spleen, tri-jiao channel.Effect: promoting QI circulation for relieving depression, menstruction regulating and pain relieving, antiabortive, regulate the flow of vital energy Shu Yu, harmonizing the liver and stomach.The pungent loose hardship of this product is let out, and is the key medicine of depressed liver-energy dispersing and QI regulating, can be used for all pain cards caused by irritability stasis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": adjust the gas in blood, dissipating depression of QI, alleviating distention in middle-JIAO, helps digestion." book on Chinese herbal medicine is looked for the truth ": Rhizoma Cyperi, exclusive dissipating depression of QI falls apart gas, and with Radix Aucklandiae circulation of qi promoting, looks are with real different, and Radix Aucklandiae abnormal smells from the patient hardship is bad, therefore ventilation is very prompt, and this is then bitter and not very, therefore resolving depression is in the majority, and property and in the Radix Aucklandiae, therefore can add and subtract discrepancy, thinks circulation of qi promoting obstruction-removing prescription, otherwise should this and those ears unsuitable.

Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis has inhibitory action to central nervous system, and volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia.For blood deficiency and yellow complexion, dizzy cardiopalmus, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores.Carry according to " book on Chinese herbal medicine is just ": " its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, nothing unsuitable." modern medicine study confirmation, Radix Angelicae Sinensis has antibacterial, antiinflammation.

Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Nature and flavor: bitter, are slightly cold.Return Liver Channel.Effect: eliminating stasis to stop pain, clearing away heat and cooling blood, detumescence.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.This product hardship is fallen, and has effect of promoting blood circulation to restore menstrual flow, loose Yu Xiao wei, row stagnation pain.Often join Cortex Moutan.For the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, this product bitter cold, main enter Liver Channel, be apt to away blood system, can clearing away liver-fire, except blood system is hot and suffocating and have the merit of removing heat from blood, hemostasis, dissipating blood stasis speckle removing.

Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia/miltiorrhizaBge.Nature and flavor: bitter, are slightly cold.Gui Jing: enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps.Containing cryptotanshinone, dihydrotanshinone in red sage formulation, there is inhibitory action to external staphylococcus, escherichia coli, degeneration bacillus.Radix Salviae Miltiorrhizae energy blood circulation promoting and blood stasis dispelling, to the hypertrophy eliminating hepatic fibrosis connective tissue, also may have certain effect.Modern medicine experiment proves, Radix Salviae Miltiorrhizae also has anti-platelet aggregation, reduces the function of blood viscosity and the inside and outside blood coagulation system of adjustment.

Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W. T. Wang.Nature and flavor: acrid, bitter, warm.Return liver, spleen channel.Effect: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.The pungent loose temperature of this product is led to, the stagnation of QI in energy promoting the circulation of blood, stasis in gas, blood-activating and qi-promoting pain relieving, and the kind multiple pain controlled caused by stagnation of QI and blood, its analgesic effect is excellent.

Radix Bupleuri: be Umbelliferae herbaceos perennial Radix Bupleuri Bupleurum chinense DC.(Radix Bupleuri) or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd.(Radix Bupleuri Scorzonerifolii) root or herb.Nature and flavor: bitter, pungent, be slightly cold.Return liver, gallbladder meridian.Effect: reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang.Radix Bupleuri has the effect of good dispersing the stagnated live-QI to relieve the stagnation of QI, is the key medicine for the treatment of irritability stasis.

Fructus Aurantii: be the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof.Nature and flavor: bitter, pungent, sour, temperature.Return spleen, stomach warp.Effect: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.

Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor: pungent, bitter, cold.Return liver, the heart, lung meridian.Effect: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, removing heat from blood removing blood stasis with potent drugs.Cure mainly: all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.The pungent loose hardship of this product is let out, heat clearing away cold in nature, can have one's ideas straightened out by heart fire-clearing upset-relieving.

Radix Platycodonis: be the root of dicotyledon campanulaceae Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A. DC..Nature and flavor are bitter, pungent, tepor.Enter lung meridian.Effect: lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.Radix Platycodonis is lung meridian edema caused by disorder of QI medicine, and pains are put down, and namely rises and falls, being good at a surname and opening lung qi, therefore exopathogen violates lung, cough with copious phlegm, and disease such as grade uncomfortable in chest of having a stuffy nose, no matter cold and heat all can adapted.

Lignum Sappan: be the dry duramen of leguminous plant Lignum Sappan (Caesalpinia sappanL.).Nature and flavor are sweet, salty, pungent, cool.GUIXIN; Liver; Stomach; Spleen channel.Effect: blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.

Ramulus Cinnamomi: be the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor: acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Modern medicine study confirm, Ramulus Cinnamomi can effectively blood vessel dilating, promote diaphoresis, contained cinnamic aldehyde, natrium cinnamicum have antipyretic, analgesia, calmness, anticonvulsant action, in addition Ramulus Cinnamomi antibacterial, antiviral effect in addition.Ramulus Cinnamomi is warm in nature, and the kind gas that activates yang, can change YIN-cold, hold back resistance yang-energy to YIN-cold, and body fluid can not defeated cloth, the thus disease of retention of water-damp formation phlegm retention.

Fructus Trichosanthis: be the dry mature seed of cucurbitaceous plant Fructus Trichosanthis Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harms Trichosanthes rosthornii Harms.Nature and flavor: sweet, bitter, cold.Enter lung, stomach, large intestine channel.Effect: moistening the lung and resolving phlegm, promoting the circulation of QI the chest stuffiness relieving, eliminating stagnation, intestine moistening.This product and the Rhizoma Pinelliae, again can relieving stuffiness of the chest by dispersing aggregation of pathogens with can Qinghua heat-phlegm, and use same with Fructus Aurantii Immaturus, has the merit of removing heat from the lung and dissipating phlegm.

Bulbus Allii Macrostemonis: be the dry bulb of liliaceous plant Allium macrostemon Allium macrostemon Bge. or Chinese onion Allium chinensis G. Don.Nature and flavor: pungent, bitter, temperature.Return lung, stomach, large intestine channel.Effect: activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.For thoracic obstruction pain, phlegm retention cough with asthma is heavy after letting out dysentery.Pharmaceutical research shows, has the effect of the chest stuffiness relieving promoting the circulation of QI to relieve pain, is applicable to the uncomfortable in chest of coronary heart disease and does not relax or angina pectoris, old people's chronic enteritis, bacillary dysentery.

Rhizoma Zingiberis: be the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: pungent, hot.Return spleen, stomach, the heart, lung meridian.Effect: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.This product hot dry strong, main enter taste warp, be longer than warm middle burnt spleen sun and cold expelling, therefore all middle burnt cold syndrome, the excess-cold syndrome of no matter invading in exogenous cold, or the deficiency-cold syndrome of YANG QI deficiency, be key medicine.

Herba Asari: be aristolochiaceae plant Herba Asari Asarum heterotropoides Fr. Schmidt var.mandshuricum(Maxim.) the dry herb of Kitag., Seoul Herba Asari Asarum sieboldii Miq. var. seoulense Nakai or magnificent Herba Asari Asarum sieboldii Miq..Nature and flavor: pungent; Temperature; Mild toxicity.Return lung meridian, kidney channel, heart channel, Liver Channel, gallbladder meridian, spleen channel.Effect: mass dissipating and swelling eliminating; Induce sweat cold expelling; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention; The therapeutic method to keep the adverse QI flowing downwards is eliminated the phlegm, sensible.Antibacterial, antivirus action kakuol preserved material, volatilization wet goods have certain In-vitro Inhibitory Effect to gram positive bacteria, bacillus subtilis and Bacillus typhi, and decoct also has inhibitory action to tubercule bacillus and Bacillus typhi.Herba Asari volatile oil is to multiple fungus as Aspergillus flavus, Aspergillus niger, Candida albicans etc. all have inhibitory action, and antibacterial effective ingredient is safrole.

Side's solution of the present invention is: Radix Astragali tonifying Qi and lifting yang in side, regulating fluid apssage, Radix Pseudostellariae mends strengthening spleen and lung, supplementing QI for promoting the production of body fluid, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, Radix Rhodiolae Fructus Alpiniae Oxyphyllae is nourished heart, dissipating blood stasis for subsidence of swelling, Semen Persicae (parched), Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, above seven tastes are monarch drug altogether, the Fructus Alpiniae Oxyphyllae of fundamentally carrying out of disease is nourished heart altogether, tonifying Qi and lifting yang, and be all the stable medicine of the property of medicine, better for chronic disease therapy effect, and Semen Persicae (parched) Flos Carthami goes directly, focus carries out eliminating stasis to stop pain, control cardiovascular further blocks, reach therapeutic purposes further.Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping, Radix Rehmanniae Preparata nourishing YIN and supplementing blood, beneficial essence fill out marrow, Fructus Corni liver and kidney tonifying, Rhizoma Cyperi promoting QI circulation for relieving depression, Chinese angelica blood supplementing is invigorated blood circulation, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae eliminating stasis to stop pain, Rhizoma Corydalis blood circulation promoting regulates qi, above seven tastes are ministerial drug altogether, the effect that the blood-activating and qi-promoting of enhancing monarch drug, Fructus Alpiniae Oxyphyllae nourish heart, multi-medicament also has the proliferative effect eliminating fibrous connective tissue, can treat the disturbance of blood circulation that pericardial thickening causes.Radix Bupleuri reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, Fructus Aurantii regulating the flow of QI to ease the stomach, Radix Curcumae heart fire-clearing upset-relieving, the evacuation of pus of Radix Platycodonis lung qi dispersing, Lignum Sappan blood circulation promoting and blood stasis dispelling, Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, Fructus Trichosanthis promoting the circulation of QI the chest stuffiness relieving, Bulbus Allii Macrostemonis activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving, Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, Herba Asari mass dissipating and swelling eliminating, a few taste is adjuvant drug altogether above, the health of conditioning patient, strengthens curative effect of medication, promotes that patient recovers.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, have tonifying Qi and lifting yang, Fructus Alpiniae Oxyphyllae is nourished heart, effect of promoting diuresis to eliminate damp pathogen, dissipating blood stasis for subsidence of swelling, effectively can treat constrictive pericarditis.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Astragali 45-55 part, Radix Pseudostellariae 7-17 part, Rhizoma Atractylodis Macrocephalae (parched) 19-29 part, Poria 10-20 part, Radix Rhodiolae 15-25 part, Semen Persicae (parched) 7-17 part, Flos Carthami 4-14 part, Rhizoma Chuanxiong 10-20 part, Radix Rehmanniae Preparata 13-23 part, Fructus Corni 7-17 part, Rhizoma Cyperi 10-20 part, Radix Angelicae Sinensis 13-23 part, Radix Paeoniae Rubra 10-20 part, Radix Salviae Miltiorrhizae 15-25 part, Rhizoma Corydalis 13-23 part, Radix Bupleuri 7-17 part, Fructus Aurantii 10-20 part, Radix Curcumae 10-20 part, Radix Platycodonis 13-23 part, Lignum Sappan 7-17 part, Ramulus Cinnamomi 10-20 part, Fructus Trichosanthis 19-29 part, Bulbus Allii Macrostemonis 5-15 part, Rhizoma Zingiberis 10-20 part, Herba Asari 1-5 part.

Wherein be preferably: the Radix Astragali 50 parts, Radix Pseudostellariae 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Radix Rhodiolae 20 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Rhizoma Chuanxiong 15 parts, Radix Rehmanniae Preparata 18 parts, Fructus Corni 12 parts, Rhizoma Cyperi 15 parts, Radix Angelicae Sinensis 18 parts, Radix Paeoniae Rubra 15 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Corydalis 18 parts, Radix Bupleuri 12 parts, Fructus Aurantii 15 parts, Radix Curcumae 15 parts, Radix Platycodonis 18 parts, Lignum Sappan 12 parts, Ramulus Cinnamomi 15 parts, Fructus Trichosanthis 24 parts, Bulbus Allii Macrostemonis 10 parts, Rhizoma Zingiberis 15 parts, Herba Asari 3 parts.

Medicine of the present invention can adopt the conventional fabrication process of Chinese medicine preparation, can be made into said dosage form on any one pharmaceutics, as pill, powder, tablet, capsule, granule, syrup, oral liquid etc.Such as these crude drug grind into fine powder mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.

The preferred preparation method of the present invention is decoction, and its preparation method is as follows:

Step one: by weight proportion of the present invention, take the Radix Astragali, Radix Pseudostellariae, Rhizoma Chuanxiong, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Radix Curcumae, Radix Platycodonis, Lignum Sappan, Rhizoma Zingiberis put into marmite and add cold water, exceed powder 3 ~ 4 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 ~ 5 centimetres is added in residue medicinal residues, add Poria, Radix Rhodiolae, Fructus Corni, Rhizoma Corydalis, Radix Bupleuri, Fructus Aurantii, Fructus Trichosanthis, Bulbus Allii Macrostemonis, Herba Asari decoct 30 minutes, finally add Flos Carthami, Ramulus Cinnamomi decocts 10 minutes, filter, waste, for subsequent use;

Step 2: by weight proportion of the present invention, takes Rhizoma Atractylodis Macrocephalae (parched), Semen Persicae (parched), Radix Rehmanniae Preparata drying, grinds to 180 mesh sieves, for subsequent use;

Step 3: twice filtrate in step one is merged, adds the powder in step 2 while hot, stir, both the decoction for the treatment of constrictive pericarditis of the present invention.

The effects such as medicine of the present invention has tonifying Qi and lifting yang, Fructus Alpiniae Oxyphyllae is nourished heart, promoting diuresis to eliminate damp pathogen, dissipating blood stasis for subsidence of swelling, and therapeutic effect is good, not easily recur, cheap, healing time is short, taking convenience, adds up according to clinical 180 routine patient view, use medicine of the present invention the total effective rate course for the treatment of 85%, two the total effective rate course for the treatment of 95%.

Detailed description of the invention

Embodiment one, the Radix Astragali 45 parts, Radix Pseudostellariae 7 parts, Rhizoma Atractylodis Macrocephalae (parched) 19 parts, 10 parts, Poria, Radix Rhodiolae 15 parts, Semen Persicae (parched) 7 parts, 4 parts, Flos Carthami, Rhizoma Chuanxiong 10 parts, Radix Rehmanniae Preparata 13 parts, Fructus Corni 7 parts, Rhizoma Cyperi 10 parts, Radix Angelicae Sinensis 13 parts, Radix Paeoniae Rubra 10 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Corydalis 13 parts, Radix Bupleuri 7 parts, Fructus Aurantii 10 parts, Radix Curcumae 10 parts, Radix Platycodonis 13 parts, Lignum Sappan 7 parts, Ramulus Cinnamomi 10 parts, Fructus Trichosanthis 19 parts, Bulbus Allii Macrostemonis 5 parts, Rhizoma Zingiberis 10 parts, Herba Asari 1 part.

Embodiment two, the Radix Astragali 50 parts, Radix Pseudostellariae 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Radix Rhodiolae 20 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Rhizoma Chuanxiong 15 parts, Radix Rehmanniae Preparata 18 parts, Fructus Corni 12 parts, Rhizoma Cyperi 15 parts, Radix Angelicae Sinensis 18 parts, Radix Paeoniae Rubra 15 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Corydalis 18 parts, Radix Bupleuri 12 parts, Fructus Aurantii 15 parts, Radix Curcumae 15 parts, Radix Platycodonis 18 parts, Lignum Sappan 12 parts, Ramulus Cinnamomi 15 parts, Fructus Trichosanthis 24 parts, Bulbus Allii Macrostemonis 10 parts, Rhizoma Zingiberis 15 parts, Herba Asari 3 parts.

Embodiment three, the Radix Astragali 55 parts, Radix Pseudostellariae 17 parts, Rhizoma Atractylodis Macrocephalae (parched) 29 parts, 20 parts, Poria, Radix Rhodiolae 25 parts, Semen Persicae (parched) 17 parts, 14 parts, Flos Carthami, Rhizoma Chuanxiong 20 parts, Radix Rehmanniae Preparata 23 parts, Fructus Corni 17 parts, Rhizoma Cyperi 20 parts, Radix Angelicae Sinensis 23 parts, Radix Paeoniae Rubra 20 parts, Radix Salviae Miltiorrhizae 25 parts, Rhizoma Corydalis 23 parts, Radix Bupleuri 17 parts, Fructus Aurantii 20 parts, Radix Curcumae 20 parts, Radix Platycodonis 23 parts, Lignum Sappan 17 parts, Ramulus Cinnamomi 20 parts, Fructus Trichosanthis 29 parts, Bulbus Allii Macrostemonis 15 parts, Rhizoma Zingiberis 20 parts, Herba Asari 5 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept out-patient 180 example for medical treatment, wherein male 93 example, women 87 example, M-F is about 1.06:1, max age 68 years old, minimal ages 30 years old, and the course of disease time, not etc. every basic documents such as Gender, age, the course of disease were substantially not identical.

Two, Therapeutic Method

According to Medications Example two of the present invention, weighting raw materials (daily dose), decocting, filter and remove residue, takes at twice, within 10th, is a course for the treatment of.

Three, efficacy assessment standard

1, cure: clinical symptoms all disappears, and test chamber inspection is normal;

2, take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal;

3, do not heal: clinical symptoms is without being clearly better or increasing the weight of.

Four, observation group's result statistics

Wherein: total effective rate=cure rate+improvement rate

Shown by the statistics of therapeutic outcome, Chinese medicine of the present invention has good clinical effectiveness at treatment constrictive pericarditis, is worth promoting in clinical practice.

Model case and curative effect:

Case one, Zheng, female, 55 years old, patient occurs that breast is vexed repeatedly, the symptom such as to breathe hard, main manifestations is for engender upstairs in this year, during upward slope, breast is vexed, breathe hard, edema is there will be time serious, patient removes examination in hospital, there is obvious hydrothorax on right side, podiod increases, calcification of pericardium, clarify a diagnosis as constrictive pericarditis, patient refused hands art at that time, determine the Therapeutic Method adopting Chinese medicine, adopt made preparation in the embodiment of the present invention two, and the preparation method preferably selected, after taking two courses for the treatment of, the phenomenon of sensation of oppression over the chest with shortness of breath takes a turn for the better to some extent, because primary disease is a kind of chronic disease, patient adheres to again having taken the course for the treatment of more than three, readme upstairs, climb not difficult, and edema phenomenon does not also occur again since taking medicine, patient goes to hospital to check, podiod phenomenon disappears, various inspection is all normal, recovery from illness.

Case two, Guo, man, 69 years old, patient feels cardiopalmus in the recent period, sometimes with the exertional dyspnea continued, patient removes examination in hospital, chest impact is learned and is checked that hydrops appears in thoracic cavity, prompting right side, atrium and postcava have the phenomenon of expansion, add other every Basic examination, clarify a diagnosis as constrictive pericarditis, patient adheres to not carrying out hands art, adopt made preparation in the embodiment of the present invention two, and the preparation method preferably selected, after taking two courses for the treatment of, breathe hard, the phenomenon of cough cardiopalmus is clearly better, patient checks and takes about two months, dyspnea, the phenomenon of edema of lower limbs disappears completely, patient goes to hospital to check, imaging examination of chest is normal, venectasia phenomenon is obviously taken a turn for the better, livelihood restoration is normal, recovery from illness.

Claims (4)

1. treat the Chinese medicine preparation of constrictive pericarditis for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Astragali 45-55 part, Radix Pseudostellariae 7-17 part, Rhizoma Atractylodis Macrocephalae (parched) 19-29 part, Poria 10-20 part, Radix Rhodiolae 15-25 part, Semen Persicae (parched) 7-17 part, Flos Carthami 4-14 part, Rhizoma Chuanxiong 10-20 part, Radix Rehmanniae Preparata 13-23 part, Fructus Corni 7-17 part, Rhizoma Cyperi 10-20 part, Radix Angelicae Sinensis 13-23 part, Radix Paeoniae Rubra 10-20 part, Radix Salviae Miltiorrhizae 15-25 part, Rhizoma Corydalis 13-23 part, Radix Bupleuri 7-17 part, Fructus Aurantii 10-20 part, Radix Curcumae 10-20 part, Radix Platycodonis 13-23 part, Lignum Sappan 7-17 part, Ramulus Cinnamomi 10-20 part, Fructus Trichosanthis 19-29 part, Bulbus Allii Macrostemonis 5-15 part, Rhizoma Zingiberis 10-20 part, Herba Asari 1-5 part.

2. the Chinese medicine preparation of the treatment constrictive pericarditis according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: the Radix Astragali 50 parts, Radix Pseudostellariae 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Radix Rhodiolae 20 parts, Semen Persicae (parched) 12 parts, 9 parts, Flos Carthami, Rhizoma Chuanxiong 15 parts, Radix Rehmanniae Preparata 18 parts, Fructus Corni 12 parts, Rhizoma Cyperi 15 parts, Radix Angelicae Sinensis 18 parts, Radix Paeoniae Rubra 15 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Corydalis 18 parts, Radix Bupleuri 12 parts, Fructus Aurantii 15 parts, Radix Curcumae 15 parts, Radix Platycodonis 18 parts, Lignum Sappan 12 parts, Ramulus Cinnamomi 15 parts, Fructus Trichosanthis 24 parts, Bulbus Allii Macrostemonis 10 parts, Rhizoma Zingiberis 15 parts, Herba Asari 3 parts.

3. the Chinese medicine preparation for the treatment of constrictive pericarditis according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.

4. treat the preparation method of the Chinese medicine preparation of constrictive pericarditis for one kind, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, take the Radix Astragali, Radix Pseudostellariae, Rhizoma Chuanxiong, Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Radix Curcumae, Radix Platycodonis, Lignum Sappan, Rhizoma Zingiberis is put into marmite and adds cold water, exceed powder 3 ~ 4 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 ~ 5 centimetres is added in residue medicinal residues, add Poria, Radix Rhodiolae, Fructus Corni, Rhizoma Corydalis, Radix Bupleuri, Fructus Aurantii, Fructus Trichosanthis, Bulbus Allii Macrostemonis, Herba Asari decocts 30 minutes, finally add Flos Carthami, Ramulus Cinnamomi decocts 10 minutes, filter, waste, for subsequent use, step 2: by weight proportion of the present invention, takes Rhizoma Atractylodis Macrocephalae (parched), Semen Persicae (parched), Radix Rehmanniae Preparata drying, grinds to 180 mesh sieves, for subsequent use, step 3: twice filtrate in step one is merged, adds the powder in step 2 while hot, stir, both the decoction for the treatment of constrictive pericarditis of the present invention.