CN104888091A - Traditional Chinese medicine composition for treating intestinal form of acute radiation sickness and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating intestinal form of acute radiation sickness and preparation method of traditional Chinese medicine composition Download PDF

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CN104888091A
CN104888091A CN201510370354.XA CN201510370354A CN104888091A CN 104888091 A CN104888091 A CN 104888091A CN 201510370354 A CN201510370354 A CN 201510370354A CN 104888091 A CN104888091 A CN 104888091A
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fructus
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吴伟强
袁延光
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Abstract

The invention discloses a traditional Chinese medicine composition for treating an intestinal form of acute radiation sickness. The traditional Chinese medicine composition comprises radix astragali preparata, radix codonopsis, parched rice-grain sprouts, parched hawthorn fruits, fried malt, parched medicated leaven, fingered citron, fructus citri, perilla stems, pogostemon cablin, fortune eupatorium herb, roasted rhizoma atractylodis macrocephalae, poria cocos, yams, black sesame, lotus seeds, fiveleaf gynostemma herb, raw semen coicis, achyranthes bidentata, mulberries, donkey-hide glue, deer-horn glue, fructus amomi, round cardamom fruit and glycyrrhizae in a certain weight proportion. The traditional Chinese medicine composition is capable of benefiting the lung and the spleen, tonifying Qi, promoting Yang, helping digestion, regulating the middle warmer, strengthening the spleen and promoting appetite and is capable of treating the intestinal form of acute radiation sickness effectively.

Description

A kind of Chinese medicine composition for the treatment of gastrointestinal acute radiation disease and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of gastrointestinal acute radiation disease.The invention still further relates to the preparation method of this Chinese medicine composition.
Background technology
Gastrointestinal acute radiation disease is also known as gastrointestinal type acute radiation sickness.Personnel suffer heavy dose (about 1 at short notice, more than 000 rad) after gamma ray or gamma ray and neutron mixed exposure, except hemopoietic tissue is subject to heavy damage, key pathological change shows gastrointestinal system, particularly disorder of the small intestine changes to outstanding, the necrosis of epithelium of intestinal mucosa generation popularity comes off, therefore is called enter radiation disease.Gastrointestinal acute radiation disease be vomit, suffer from diarrhoea, very serious acute radiation sickness that the gastrointestinal symptom such as blood watery stool is principal character, its traumatic condition is serious, development is fast, Staging of course of disease is not obvious, and life span is short, how dead in a short time.Primary disease take injury of gastrointestinal tract as basic lesion, for have the initial stage, latent phase and crisis three the stage course of disease serious acute radiation sickness.Wherein, except shining in rear 1h and occurring severe nausea, vomiting, there is diarrhoea, loose stool, blood and slime just in 1 ~ 3 day in slight gastrointestinal acute radiation disease, and have the initial symptoms such as parotid gland swelling and pain, after 3 ~ 6 days latent phases, above-mentioned symptom increases the weight of, crisis, can with blood, watery stool, heating.And namely there are frequent vomiting, insufferable stomachache, serious rare aquiform stool, pachyemia, dehydration, cachexia, hypothermia etc. by according in latter 1 day in severe gastrointestinal acute radiation disease.Then hyperemesis bile or coffee sample thing, during severe patient second week blood and slime just or just in be mixed with the Intestinal Mucosal Tissues come off, fecal incontinence, high heat etc.
At ordinary times, radiation accident irradiates and can cause acute or subacute radiation sickness and skin injury.Person does not note protection to accept lonizing radiation, long-term by according in the ray exceeding dose limit, can obtain chronic radiation disease yet.The mainly cell of damaged, there is clinical symptoms, causes radiation sickness in organ-tissue loss of function after cell damage wound.The weight of tissue damaged depends on that the cell of dose radiation size, damaged is how many, scope and whether important by the Organ and tissue according to position.It is generally acknowledged, the coup injury of radiation shows as the death of cell, can not breed new tissue again, and resistance reduces, and angiorrhexis is hemorrhage, tissue collapse, bleeding and cotting time prolongation etc.The indirect injury of radiation can cause tumor, leukemia, the lost of life, repeated infection, and anemia and ulcer etc. occur.The local damage of radiation can occur by according to rear some months or a few Nian Houcai.Systemic disease only in body the impaired or whole body of several organ-tissue by according to time just generation.
Increasing of current amiable nuclear power station, and inevitable some malpracticees, gastrointestinal acute radiation disease also causes the concern of people gradually, but does not have what specific drug for this type of disease at present, and also many patients still endure the puzzlement of disease to the fullest extent.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has evident in efficacy for treatment gastrointestinal acute radiation disease, cheap, easy to use, the feature had no side effect.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment gastrointestinal acute radiation disease.
Inventor is in clinical treatment practice for many years, observe the misery that frequent gastrointestinal acute radiation disease is brought to patient, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of gastrointestinal acute radiation disease repeatedly, the present invention selects Radix Astragali Preparata, Radix Codonopsis, Fructus Setariae Germinatus (parched), Fructus Crataegi (parched), Fructus Hordei Germinatus (parched), Massa Medicata Fermentata preparata, Fructus Citri Sarcodactylis, Fructus Citri, Caulis Perillae, Herba Pogostemonis, Herba Eupatorii, Rhizoma Atractylodis Macrocephalae (parched), Poria, Rhizoma Dioscoreae, Semen Sesami Nigrum, Semen Nelumbinis, Herb Gynostemmae Pentaphylli, Semen Coicis, Radix Achyranthis Bidentatae, Fructus Mori, Colla Corii Asini, Colla cornus cervi, Fructus Amomi, Fructus Amomi Rotundus, Radix Glycyrrhizae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is benefit strengthening spleen and lung, tonifying Qi and lifting yang, help digestion and in, effect of spleen benefiting and stimulating the appetite, thus effectively can treat gastrointestinal acute radiation disease.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Astragali Preparata: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: tonifying Qi and lifting yang, consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.On the books in " book on Chinese herbal medicine converges and says ": " Radix Astragali, tonifying the lung spleen invigorating defend arresting sweating in fact, and the medicine of wind dispelling fortune poison also.Therefore the people of yang deficiency, spontaneous perspiration frequently comes, be exterior deficiency and interspaces of skin and muscles being loose also, he the Radix Astragali can be defended and arresting sweating in fact; The card of typhoid fever, row is delivered and evil no sweating, and be interior deficiency and also weary in healthy energy, the Radix Astragali can help Tianjin to help antiperspirant; The disease of harmful wind, inclined invasion of vessels and brothers are not with person, and the Radix Astragali can flourish muscles and bones; The card of carbuncle and ulcer, pus and blood internal ulceration, deficiency of YANG QI and do not hold back person, the Radix Astragali can granulation promoting meat, and the erosion of vulva can not rise and send out again, deficiency of YANG QI and unhealed, and the Radix Astragali can granulation promoting meat." this product all has inhibitory action to dysentery bacterium, anthrax bacillus, α-hemolytic streptococcus, beta hemolytic streptococcus, diphtheria corynebacterium, bacillus pseudodiphthericus, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, bacillus subtilis etc. in vitro.
Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis Codonopsis pilosula Nannf.var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Nature and flavor: sweet, flat.Return spleen, lung meridian.Effect: mend strengthening spleen and lung, nourishing blood to promote the production of body fluid.For deficiency of the spleen and lung, breathe hard, cardiopalmus, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst." Bencao Congxin " is recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.Middle feeble QI is weak, mends in order to adjust, very smooth and proper." acid mucopolysaccharide in Radix Codonopsis has anticoagulant, can reduce blood fat and reduce blood viscosity and plasma viscosity, and have blood pressure lowering, blood fat reducing, antioxidation, defying age, improves the immunity of human body.
Fructus Setariae Germinatus (parched): for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv. is through germinateing drying and obtaining.Fructus Setariae Germinatus (parched): put in pot and fry to buff and the explosion of large portion with slow fire, taking-up cools.Fructus Setariae Germinatus (parched to brown): put by Fructus Setariae Germinatus in pot, fries to coke yellow with high heat, and micro-spray clear water, takes out air-dry.Nature and flavor: sweet, temperature.Return spleen, stomach warp.Effect: help digestion and in, spleen benefiting and stimulating the appetite.Do not disappear for food stagnation, abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite.Fructus Setariae Germinatus (parched) relatively helps digestion, for not hungry lack of appetite.It is stagnant that Fructus Setariae Germinatus (parched to brown) is apt to eliminate indigestion, do not disappear for stagnant." Bencao Jingshu ": tiller rice and rice tiller are also.The property of tool biochemistry, thus be digestion-promoting spleen-invigorating, appetizing and in key medicine, taste and then in from pestilence, gas under, heat is from except also.
Fructus Crataegi (parched): be the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge.var.major N.E.Br. or Fructus Crataegi Crataegus pinnatifida Bge..Nature and flavor: sour, sweet, tepor.Return spleen, stomach, Liver Channel.Effect: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.Modern pharmacological research shows: triterpenic acid contained in Fructus Crataegi can improve coronary circulation and that coronary artery sexual exhaustion is able to is compensatory, reaches cardiotonic.
Fructus Hordei Germinatus (parched): for the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. is through germinateing drying and obtaining.Nature and flavor: sweet are flat.Return spleen, stomach warp.Effect: promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn relieving distension.Do not disappear for food stagnation, abdominal distention, insufficiency of the spleen lack of appetite, milk smoulders, distending pain of the breast, and women weans.
Massa Medicata Fermentata preparata: for the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven of fermentation.Nature and flavor: sweet, pungent, warm.Return spleen, stomach warp.Effect: invigorating the spleen and regulating the stomach, helps digestion in adjusting.Control retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis is suffered from abdominal pain, and children's's enlarged abdomen heavily fortified point is long-pending.
Fructus Citri Sarcodactylis: be the dry fruit of rutaceae Fructus Citri Sarcodactylis Citrus medica L. var. sarcodactylis Swingle.Nature and flavor are pungent, bitter, sour, temperature.Return liver, spleen, lung meridian.Effect: liver-smoothing, qi-regulating, and stomach and alleviating pain, dispersing the stagnated live-QI to relieve the stagnation of QI, drying dampness to eliminate phlegm.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.Modern clinical research, Fructus Citri Sarcodactylis quintessence oil has the effect of strengthening to nervous system, and one of three zones is exactly treatment melancholy and anxiety, pacifies indignation, improves the anxiety of women's heart.As neural fatigue, nerve insomnia, worn out mentally and physically time can to releive pressure.But Fructus Citri Sarcodactylis is not excited quintessence oil, it can be inspired enthusiasm and allow mental relaxation.
Fructus Citri: be the dry mature fruit of rutaceae citron Citrus medica L. or fragrant circle Citrus wilsonii Tanaka.Nature and flavor are pungent, bitter, sour, temperature.Return liver, lung, spleen channel.Effect: regulating the flow of QI to ease the stomach, expectorant falls in relieving distension.Contained volatile oil has gentle stimulation to gastrointestinal tract, can promote to wriggle and digestive juice secretion in the intestines and stomach, gets rid of enteral pneumatosis, and has phlegm-dispelling functions.Supplement to the Herbal: degas, except mind expectorant water.These product are pungent can manage it loose, and the catharsis of bitter energy, enters Liver Channel and can unclog and readjust irritability and pain relieving.The strongly fragrant distending pain in the chest and hypochondrium for the treatment of the liver, often joins Radix Bupleuri, Radix Curcumae, the equivalent use of Fructus Citri Sarcodactylis.The same Fructus Citri Sarcodactylis of this product merit, but effect is more inferior.Stagnation of QI abdominal distention.This product gas perfume (or spice) is amusing, and pungent row hardship is let out, and enters taste with promoting the circulation of QI to alleviate the stagnation in middle-JIAO.With the abdominal distention controlling stagnation of QI in spleen and stomach, belch acid regurgitation, vomiting and nausea lack of appetite, can be equal to the Radix Aucklandiae, Fructus Amomi, Herba Pogostemonis and use.
Caulis Perillae: be the dry stem of labiate Folium Perillae Perilla frutescens (L.) Britt..Nature and flavor: pungent, temperature.Return lung, spleen channel.Effect: regulating the flow of QI to ease the stomach, pain relieving, antiabortive." medicineization justice ": Caulis Perillae, can make the upper and lower Xuan Hang of stasis, only this is pure good for all pleasant all product.Its slightly warm in nature, more outstanding than Fructus Aurantii slow.The empty person of disease, the chest stuffiness relieving profit diaphragm, dredge gas and not fast under.Enter antiabortive drink, pleasant yin nourishing; Enter relieving distension soup, loose edema due to deficiency is full.
Herba Pogostemonis: be the herb of labiate Herba Pogostemonis Cablin Potchouli Herb or Herba Pogostemonis Wrinkled Gianthyssop Herb.Nature and flavor: pungent, tepor.Return lung, spleen, stomach warp.Effect: fast gas, and in, ward off dirty, damp eliminating.Cure cold heat-damp in summer, cold and heat, and headache, breast gastral cavity painful abdominal mass is vexed, and vomiting is had loose bowels, malaria, dysentery, halitosis.
Herba Eupatorii: be the dry aerial parts of feverfew Herba Eupatorii Eupatorium fortunei Turcz..Nature and flavor: pungent are flat.Return spleen, stomach, lung meridian.Effect: removing dampness by means of aromatics, appetizing of being amusing, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.Treatment hygropyrexia disease key medicine, the medicine fit applications such as normal and Herba Pogostemonis, Radix Scutellariae, Semen Coicis.In addition, the disease that sweet greasy sialism in damp-heat blocking in the body, mouth, implication are rancid is applicable to again.For interiorly to accumulate, fear of cold, heating, feeling of fullness in the head, the disease such as uncomfortable in chest, anorexia, often coordinate Herba Pogostemonis, Cortex Magnoliae Officinalis, Folium Nelumbinis with using.
Rhizoma Atractylodis Macrocephalae (parched): be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, the Rhizoma Atractylodis Macrocephalae can air making-up and spleen enlivening, again can dampness diuretic, is the key medicine of the spleen strengthening and damp drying.In the sweet temperature compensation of the Rhizoma Atractylodis Macrocephalae, can air making-up and spleen enlivening, also can strengthening superficial resistance to stop perspiration, and the Radix Astragali, Radix Pseudostellariae compatibility, play the merit of spleen reinforcing lung altogether.To rule together asthenia, the weak person of overstrain.Rhizoma Atractylodis Macrocephalae antibacterial action is obvious: infusion has inhibitory action to acrothesium floccosum, star nocardia in vitro.Decoct also has inhibitory action to meningococcus.The Rhizoma Atractylodis Macrocephalae also has the function promoting hemopoietic.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, is the key medicine of promoting diuresis to eliminate damp pathogen.Treatment water wet the edema of expert time, often join Rhizoma Alismatis, Polyporus.Poria decoct has obvious sedation." modality ": " cure mainly Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side." this product is by heart-spleen boosting and tranquilizing mind.Be used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.
Rhizoma Dioscoreae: be the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..Nature and flavor: flat, sweet.Return spleen, lung, kidney channel.Effect: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Semen Sesami Nigrum: be the dry mature seed of Pedaliaceae (Pedaliaceae) Sesamum plant sesame Sesamum indicum L..Nature and flavor: sweet are flat.Return liver, kidney, large intestine channel.Effect: invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.
Semen Nelumbinis: be the dry mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn..Nature and flavor: sweet, puckery are flat.Return spleen, kidney, heart channel.Effect: spleen reinforcing antidiarrheal, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.For insufficiency of the spleen chronic diarrhea, seminal emission leukorrhagia, palpitation and insomnia." Wang Shi case ": Semen Nelumbinis, most mends gastric qi and town void is inverse, if regurgitation is due to insufficiency of stomach, and person is not received in gas punching. but day chew carefully with dry Semen Nelumbinis and swallow it, be better than his medicine many.All gastric qis thin weak person's informal dress Fomitopsis officnalic Bond.et Sing ball, can make us fertile strong.To keep silent mouth to dysentery disease, pathogenic heat hinders gas cleer and peaceful in its stomach, therefore lets out with Rhizoma Coptidis hardship that it is evil, namely holds its stomach of Semen Nelumbinis Gan Zhen.Modern wantonly middle Semen Nelumbinis is all pseudo-, and bitter in the mouth instead can injure one's stomach, and can't use.Only fresh Semen Nelumbinis decoct it, and delicate fragrance is not muddy, and the merit of town stomach solely wins, and as without fresh lotus, dry lotus also can.
Herb Gynostemmae Pentaphylli: be the herb of cucurbitaceae genus gynostemma Herb Gynostemmae Pentaphylli Gynostemma pentap-hyllum (Thunb.) Makino.Nature and flavor: bitter, cold.Return lung; Spleen; Kidney channel.Effect: heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.For chronic bronchitis, infectious hepatitis, nephritis is scorching, gastroenteritis.Modern pharmacology research Herb Gynostemmae Pentaphylli not only can enhancing immunity, and has slow down aging to the effect of inhibiting tumor cell.
Semen Coicis: be the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf.Nature and flavor: sweet, light, cool.Return spleen, stomach, lung meridian.Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment pain relieving, clearing away heat and discharging pus.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.For the disease of retention of damp-heat in the interior, to oliguria with reddish urine, can be equal to Talcum, Medulla Tetrapanacis and use; To hygropyrexia pathogenic factor at edema caused by disorder of QI, the inclined victor of damp, can be equal to Semen Armeniacae Amarum, KOUREN, Folium Bambusae, Caulis Akebiae and use.This product has again a merit of spleen invigorating, and in order to control edema due to deficiency of the spleen, beriberi swells and ache, and compatibility Poria, Bai Intraoperative, Fructus Chaenomelis, Fructus Evodiae is equivalent uses.For insufficiency of the spleen have wet to have loose bowels, leukorrhagia, can Yu the compatibilities such as Bai Intraoperative, Poria.For the arthralgia pain contracture that humidity hysteresis flesh tendon causes, the fit applications such as normal and Ramulus Cinnamomi, Cang Intraoperative.Control lung abscess chest pain, cough up vomiting pus expectorant can with the compatibilities such as fresh Rhizoma Phragmitis, Semen Benincasae, Semen Persicae, Herba Houttuyniae; Control acute appendicitis, can be equal to Herba Patriniae, Radix Aconiti Lateralis Preparata and use.This product can eliminating dampness by diuresis, again can relaxing muscles and tendons arteries and veins, and slow contraction is anxious, is good at the damp dispelling muscle muscles and bones, therefore is used for arthralgia chiefly caused by damp pathogen, because it is cool in nature, therefore be more suitable for for damp and hot arthralgia pain.
Radix Achyranthis Bidentatae: be the root of Amaranthus mangostanus L. section herbaceos perennial Radix Achyranthis Bidentatae or RADIX CYATHULAE.Nature and flavor: bitter, sour, flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, conducting blood to flow downwards, invigorating the liver and kidney, bone and muscle strengthening.Radix Achyranthis Bidentatae is apt to descending, is apt to control the inferior burnt disease.
Fructus Mori: be the dry fruit ear of Moraceae deciduous tree plant Mulberry Morus alba L..Nature and flavor: sweet, sour, cold.Return liver, kidney, heart channel.Effect: nourishing YIN and benefiting blood; Promote the production of body fluid; Intestine moistening.Having a dizzy spell of main deficiency of the liver and kindey and blood deficiency damage of essence; Soreness of waist tinnitus; Early whitening of beard and hair; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; Dryness of the intestine constipation; Articular instability.Modern study confirms, containing abundant glucose, sucrose, carotene, vitamin, malic acid, tartaric acid in Fructus Mori, the nutrition that phosphorus matter etc. are abundant, and containing abundant activated protein, often eat and can significantly improve body immunity, Fructus Mori has effect of slow down aging, youthful looks retaining and skin caring." Bencao Jingshu ": Fructus Mori, sweet cold beneficial blood and heat extraction, for removing heat from blood is enriched blood the medicine of tonifying YIN, quench one's thirst due to interior-heat, deficiency of body fluid, promote the production of body fluid therefore quench the thirst.The five internal organs all belong to cloudy, the sharp the five internal organs of tonifying YIN event.The vim and vigour in deficiency of YIN then joint are obstructed, and blood promotes the production of body fluid full, and cloudy gas is long to be contained, then not hungry and vim and vigour are from logical.Heat is moved back cloudy raw, then the liver heart is without fire, therefore soul peace and god are from clear peaceful, god clear then clever in send out, cloudy multiple then bleach not old.Sweet cold heat extraction, therefore alcoholism in solution.Diuretic cold in nature and descending, therefore diuretic gas and subsiding a swelling.
Colla Corii Asini: for the skin of equine species donkey Equus Asinus L. is through decocting, concentrating the solid gum made.Nature and flavor: sweet are flat.Return lung, liver, kidney channel.Effect: YIN nourishing of enriching blood, moisturizes, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy." detailed outline ": Colla Corii Asini, will just enrich blood and liquid greatly, therefore can lung heat clearing tonifying YIN and control all cards.By Chen Ziming cloud: tonify deficiency animal glue, remove wind Colla Corii Asini.Cheng Wuji cloud: deficiency of YIN person, tonifying with drugs of thick flavor, Colla Corii Asini sweet, with nourishing YIN blood.Yang Shiying cloud: all control to breathe heavily cough, no matter the deficiency of the lung, excess of the lung, can under can temperature, palpus Colla Corii Asini is to pacify lung lung moistening, and its property is peaceful, is lung meridian key medicine.
Colla cornus cervi: for Cornu Cervi is endured through decocting, concentrated the solid gum made.Nature and flavor: sweet, salty, temperature.Return kidney, Liver Channel.Effect: temperature compensation Liver and kidney, beneficial intensive culture blood.For sexual impotence spermatorrhea, the acid of waist knee joint is cold, asthenia weakness and emaciation, metrostaxis, and hematuria of having blood in stool, carbuncle of yin nature swells and ache." book on Chinese herbal medicine converges and says ": Colla cornus cervi, kidney-Yang invigorating, gas of enriching blood, spermatogenesis marrow, the medicine of warm muscles and bones also.The main damaging the spleen and stomach labor of front Gu is exhausted, lumbago weakness and emaciation, gas marrow muscles and bones the intestines and stomach of enriching blood.Treatment of deficiency-syndrome by reinforcement, damage person trains it, and exhausted person continues it, timid person strong it, cold person warms up it, and this is the essence of blood genuss, and comparatively vegetation is merciless, more increasing one power of raising.
Fructus Amomi: be the dry mature fruit of zingiberaceous plant Fructus Amomi Amomum villosum Lour., green shell sand Amomum villosum Lour. var. xanthioides T. L. Wu et Senjen or SEMEN AMOMI LONGILIGULA Amomum longiligulare T. L. Wu.Nature and flavor: pungent, warm.Return spleen, stomach, kidney channel.Effect: removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Fructus Amomi Rotundus: be the dry mature fruit of Zingiberaceae herbaceos perennial Fructus Amomi Rotundus.Nature and flavor: pungent, temperature.Return lung, spleen, stomach warp.Effect: removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting.For distension and fullness in the abdomen that is burnt in humidity hysteresis and stagnation of QI in spleen and stomach, anorexia etc.There is the merit of removing dampness circulation of qi promoting.Normal being equal to Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, is used; Hygropyrexia from the beginning of, uncomfortable in chest not hungry, dirty and greasy fur, damp covets severe one, joins Talcum, Semen Coicis, Semen Armeniacae Amarum etc., as sanren decoction; If the inclined severe one of pathogenic heat, use can be equal to Radix Scutellariae, Talcum, as Radix Scutellariae Talcum soup.
Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.
Side's solution of the present invention is: Radix Astragali Preparata tonifying Qi and lifting yang, consolidating superficial resistance arresting sweating in side, Radix Codonopsis mends strengthening spleen and lung, nourishing blood to promote the production of body fluid, a few taste of Fructus Setariae Germinatus (parched), Fructus Hordei Germinatus (parched), Fructus Crataegi (parched), Massa Medicata Fermentata preparata jointly play help digestion and in, spleen benefiting and stimulating the appetite, a few taste is monarch drug altogether above, first Radix Astragali Preparata and Radix Codonopsis, benefit strengthening spleen and lung, nourishing blood to promote the production of body fluid, to take care of health body from the scholar of fundamentally carrying out of health, the taste of conditioning patient, four tastes next play help digestion and in effect, help alleviates patient's the intestines and stomach burden, the symptom such as diarrhoea, Nausea and vomiting for the treatment of caused by gastrointestinal acute radiation disease.Fructus Citri Sarcodactylis liver-smoothing, qi-regulating and stomach and alleviating pain, Fructus Citri, Caulis Perillae alleviating distention in middle-JIAO are regulated the flow of vital energy, the fast gas of Herba Pogostemonis and in, Herba Eupatorii is amusing appetizing, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, above eight tastes are ministerial drug altogether, increase the effect of monarch drug regulating the flow of QI to ease the stomach, strengthening the spleen to promote digestion on the one hand, another aspect dispersing the stagnated live-QI to relieve the stagnation of QI, makes to bring about the desired sensation and blood does not all have stasis in vivo, facilitating digestion, thus the phenomenon of reduction of patient gastrointestinal acute radiation disease.Semen Sesami Nigrum invigorating the liver and kidney, Semen Nelumbinis spleen reinforcing antidiarrheal, Herb Gynostemmae Pentaphylli heat-clearing and toxic substances removing, Semen Coicis spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, Radix Achyranthis Bidentatae eliminating blood stasis and inducing menstruation, Fructus Mori nourishing YIN and benefiting blood, Colla Corii Asini nourishing blood YIN nourishing, Cornu Cervi Degelatinatum temperature compensation Liver and kidney, beneficial intensive culture blood, Fructus Amomi removing dampness is whetted the appetite, Fructus Amomi Rotundus removing dampness circulation of qi promoting, a few taste is adjuvant drug altogether above, and adjuvant drug has the effect of heat-clearing and toxic substances removing, removing blood stasis evacuation of pus, and comparatively gentle scholar can support the health of patient, strengthen the body constitution of patient, and then reach the object of thoroughly curing.Radix Glycyrrhizae spleen reinforcing stomach function regulating, coordinating the actions of various ingredients in a prescription, priming return through, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, have mend strengthening spleen and lung, tonifying Qi and lifting yang, help digestion and in, effect of spleen benefiting and stimulating the appetite, effectively can treat gastrointestinal acute radiation disease.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Astragali Preparata 25-35 part, Radix Codonopsis 13-23 part, Fructus Setariae Germinatus (parched) 10-20 part, Fructus Crataegi (parched) 10-20 part, Fructus Hordei Germinatus (parched) 10-20 part, Massa Medicata Fermentata preparata 10-20 part, Fructus Citri Sarcodactylis 10-20 part, Fructus Citri 10-20 part, Caulis Perillae 15-25 part, Herba Pogostemonis 10-20 part, Herba Eupatorii 10-20 part, Rhizoma Atractylodis Macrocephalae (parched) 19-29 part, Poria 10-20 part, Rhizoma Dioscoreae 13-23 part, Semen Sesami Nigrum 15-25 part, Semen Nelumbinis 15-25 part, Herb Gynostemmae Pentaphylli 13-23 part, Semen Coicis 19-29 part, Radix Achyranthis Bidentatae 15-25 part, Fructus Mori 15-25 part, Colla Corii Asini 3-7 part, Colla cornus cervi 3-7 part, Fructus Amomi 3-9 part, Fructus Amomi Rotundus 4-14 part, Radix Glycyrrhizae 3-9 part.
Wherein be preferably: Radix Astragali Preparata 30 parts, Radix Codonopsis 18 parts, Fructus Setariae Germinatus (parched) 15 parts, Fructus Crataegi (parched) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Massa Medicata Fermentata preparata 15 parts, Fructus Citri Sarcodactylis 15 parts, Fructus Citri 15 parts, Caulis Perillae 20 parts, Herba Pogostemonis 15 parts, Herba Eupatorii 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Rhizoma Dioscoreae 18 parts, Semen Sesami Nigrum 20 parts, Semen Nelumbinis 20 parts, Herb Gynostemmae Pentaphylli 18 parts, Semen Coicis 24 parts, Radix Achyranthis Bidentatae 20 parts, Fructus Mori 20 parts, 5 parts, Colla Corii Asini, Colla cornus cervi 5 parts, Fructus Amomi 6 parts, Fructus Amomi Rotundus 9 parts, Radix Glycyrrhizae 6 parts.
A kind of preparation method for the treatment of the Chinese medicine preparation of gastrointestinal acute radiation disease is as follows:
Step one: by weight proportion of the present invention, first becomes medicated bag by Semen Sesami Nigrum, Semen Nelumbinis, Semen Coicis, Fructus Amomi bundle, is put in water and soaks about 45 minutes, filters, for subsequent use;
Step 2: by weight proportion of the present invention, by Radix Astragali Preparata, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Radix Achyranthis Bidentatae is put into after marmite adds step one immersion and is remained cold water, exceed powder 2 ~ 5 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, then Caulis Perillae is added, Herba Pogostemonis, Herba Eupatorii, Poria, Herb Gynostemmae Pentaphylli and the Rhizoma Dioscoreae bound up with gauze, decoct about 30 minutes with the medicated bag in step one, add Fructus Citri Sarcodactylis afterwards, Fructus Citri, Fructus Mori, Fructus Amomi Rotundus, Radix Glycyrrhizae decocts filtration in 20 minutes, obtain filtrate, merge twice filtrate, filter, waste, for subsequent use,
Step 3: by weight proportion of the present invention, grinds into powder be crushed to 180 mesh sieves by Fructus Setariae Germinatus (parched), Fructus Crataegi (parched), Fructus Hordei Germinatus (parched), Massa Medicata Fermentata preparata, for subsequent use;
Step 4: by the medicinal liquid in step 2, while hot Colla Corii Asini and Colla cornus cervi are carried out molten, then adding the powder in step 3, and gained mixture is being carried out concentration operation, the thick paste of relative density 1.15 ~ 1.20 under simmer down to 75 DEG C of environment, by air-dry for thick paste pulverizing, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, both the honeyed pill for the treatment of gastrointestinal acute radiation disease of the present invention.
Medicine of the present invention have mend strengthening spleen and lung, tonifying Qi and lifting yang, help digestion and in, the effect such as spleen benefiting and stimulating the appetite, and it is evident in efficacy, cheap, easy to use, have no side effect, the mode that this Chinese medicine preparation adopts is treated and can be reduced the damage of Western medicine to patient's hepatic and renal function, and the improvement accelerating the state of an illness is added up according to clinical 140 routine patient view, use medicine of the present invention the total effective rate course for the treatment of 90%, two the total effective rate course for the treatment of 97.9%.
Detailed description of the invention
Embodiment one, Radix Astragali Preparata 25 parts, Radix Codonopsis 13 parts, Fructus Setariae Germinatus (parched) 10 parts, Fructus Crataegi (parched) 10 parts, Fructus Hordei Germinatus (parched) 10 parts, Massa Medicata Fermentata preparata 10 parts, Fructus Citri Sarcodactylis 10 parts, Fructus Citri 10 parts, Caulis Perillae 15 parts, Herba Pogostemonis 10 parts, Herba Eupatorii 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 19 parts, 10 parts, Poria, Rhizoma Dioscoreae 13 parts, Semen Sesami Nigrum 15 parts, Semen Nelumbinis 15 parts, Herb Gynostemmae Pentaphylli 13 parts, Semen Coicis 19 parts, Radix Achyranthis Bidentatae 15 parts, Fructus Mori 15 parts, 3 parts, Colla Corii Asini, Colla cornus cervi 3 parts, Fructus Amomi 3 parts, Fructus Amomi Rotundus 4 parts, Radix Glycyrrhizae 3 parts.
Embodiment two, Radix Astragali Preparata 30 parts, Radix Codonopsis 18 parts, Fructus Setariae Germinatus (parched) 15 parts, Fructus Crataegi (parched) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Massa Medicata Fermentata preparata 15 parts, Fructus Citri Sarcodactylis 15 parts, Fructus Citri 15 parts, Caulis Perillae 20 parts, Herba Pogostemonis 15 parts, Herba Eupatorii 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Rhizoma Dioscoreae 18 parts, Semen Sesami Nigrum 20 parts, Semen Nelumbinis 20 parts, Herb Gynostemmae Pentaphylli 18 parts, Semen Coicis 24 parts, Radix Achyranthis Bidentatae 20 parts, Fructus Mori 20 parts, 5 parts, Colla Corii Asini, Colla cornus cervi 5 parts, Fructus Amomi 6 parts, Fructus Amomi Rotundus 9 parts, Radix Glycyrrhizae 6 parts.
Embodiment three, Radix Astragali Preparata 35 parts, Radix Codonopsis 23 parts, Fructus Setariae Germinatus (parched) 20 parts, Fructus Crataegi (parched) 20 parts, Fructus Hordei Germinatus (parched) 20 parts, Massa Medicata Fermentata preparata 20 parts, Fructus Citri Sarcodactylis 20 parts, Fructus Citri 20 parts, Caulis Perillae-25 parts, Herba Pogostemonis 20 parts, Herba Eupatorii 20 parts, Rhizoma Atractylodis Macrocephalae (parched) 29 parts, 20 parts, Poria, Rhizoma Dioscoreae 23 parts, Semen Sesami Nigrum 25 parts, Semen Nelumbinis 25 parts, Herb Gynostemmae Pentaphylli 23 parts, Semen Coicis 29 parts, Radix Achyranthis Bidentatae 25 parts, Fructus Mori 25 parts, 7 parts, Colla Corii Asini, Colla cornus cervi 7 parts, Fructus Amomi 9 parts, Fructus Amomi Rotundus 14 parts, Radix Glycyrrhizae 9 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept out-patient 140 example for medical treatment.Wherein male 66 example, women 74 example, M-F 1:1.1,38 years old mean age.
Two, Therapeutic Method
According to Medications Example two of the present invention, and pill prepared by preferred preparation method, every day 3 times, each 3-5 grain 7 days is a course for the treatment of.
Three, efficacy assessment standard
1, cure: gastrointestinal acute radiation disease transference cure, feel sick, other clinical symptoms such as belch also disappear completely, body constitution recovers normal.
2, take a turn for the better: gastrointestinal acute radiation disease symptom obviously alleviates, and body constitution is progressively recovered, and other clinical symptoms are also recovered gradually.
3, do not heal: gastrointestinal acute radiation disease and other clinical symptoms are without any improvement.
Four, therapeutic outcome statistics
Wherein: total effective rate=cure rate+improvement rate
As can be seen from above-mentioned, Chinese medicine of the present invention has good clinical effectiveness in treatment gastrointestinal acute radiation disease, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Model case and curative effect:
Case one, poplar, female, 46 years old, patient suffers from cancer, treat in the mode of hospital's chemicotherapy, feeling sick appears in nearest patient, the phenomenon of vomiting, through examination in hospital, finally be diagnosed as gastrointestinal acute radiation disease, patient is appetite extreme difference therefore, within time serious one day, only eat a meal, adopt made preparation in the embodiment of the present invention two, and selected preparation method, after taking treatment a period of time, symptom is eased, feel sick, the phenomenon of vomiting all obviously disappears, patient continues two courses for the treatment of of use, patient clinical symptom disappears completely, being enhanced of body constitution, recovery from illness.
Case two, Wang, man, 68 years old, the radioactive material of patient's Long Term Contact, occur the phenomenon of feeling sick in the recent period, patient removes examination in hospital, finally be diagnosed as gastrointestinal acute radiation disease, patient adopts case two method of the present invention, after taking a course for the treatment of, gastrointestinal acute radiation disease alleviates, feel sick, the clinical symptoms such as belch is eased, continue to take a course for the treatment of, readme health takes a turn for the better, indices recovers normal on inspection, recovery from illness.

Claims (4)

1. treat the Chinese medicine composition of gastrointestinal acute radiation disease for one kind, it is characterized in that, this Chinese medicine composition is made up of the medicine of following weight portion: Radix Astragali Preparata 25-35 part, Radix Codonopsis 13-23 part, Fructus Setariae Germinatus (parched) 10-20 part, Fructus Crataegi (parched) 10-20 part, Fructus Hordei Germinatus (parched) 10-20 part, Massa Medicata Fermentata preparata 10-20 part, Fructus Citri Sarcodactylis 10-20 part, Fructus Citri 10-20 part, Caulis Perillae 15-25 part, Herba Pogostemonis 10-20 part, Herba Eupatorii 10-20 part, Rhizoma Atractylodis Macrocephalae (parched) 19-29 part, Poria 10-20 part, Rhizoma Dioscoreae 13-23 part, Semen Sesami Nigrum 15-25 part, Semen Nelumbinis 15-25 part, Herb Gynostemmae Pentaphylli 13-23 part, Semen Coicis 19-29 part, Radix Achyranthis Bidentatae 15-25 part, Fructus Mori 15-25 part, Colla Corii Asini 3-7 part, Colla cornus cervi 3-7 part, Fructus Amomi 3-9 part, Fructus Amomi Rotundus 4-14 part, Radix Glycyrrhizae 3-9 part.
2. the Chinese medicine composition of the treatment gastrointestinal acute radiation disease according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Astragali Preparata 30 parts, Radix Codonopsis 18 parts, Fructus Setariae Germinatus (parched) 15 parts, Fructus Crataegi (parched) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Massa Medicata Fermentata preparata 15 parts, Fructus Citri Sarcodactylis 15 parts, Fructus Citri 15 parts, Caulis Perillae 20 parts, Herba Pogostemonis 15 parts, Herba Eupatorii 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Rhizoma Dioscoreae 18 parts, Semen Sesami Nigrum 20 parts, Semen Nelumbinis 20 parts, Herb Gynostemmae Pentaphylli 18 parts, Semen Coicis 24 parts, Radix Achyranthis Bidentatae 20 parts, Fructus Mori 20 parts, 5 parts, Colla Corii Asini, Colla cornus cervi 5 parts, Fructus Amomi 6 parts, Fructus Amomi Rotundus 9 parts, Radix Glycyrrhizae 6 parts.
3. the Chinese medicine preparation for the treatment of gastrointestinal acute radiation disease according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is pill.
4. treat a preparation method for the Chinese medicine preparation of gastrointestinal acute radiation disease, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, first Semen Sesami Nigrum, Semen Nelumbinis, Semen Coicis, Fructus Amomi bundle are become medicated bag, be put in water and soak about 45 minutes, filter, for subsequent use, step 2: by weight proportion of the present invention, by Radix Astragali Preparata, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Radix Achyranthis Bidentatae is put into after marmite adds step one immersion and is remained cold water, exceed powder 2 ~ 5 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, then Caulis Perillae is added, Herba Pogostemonis, Herba Eupatorii, Poria, Herb Gynostemmae Pentaphylli and the Rhizoma Dioscoreae bound up with gauze, decoct about 30 minutes with the medicated bag in step one, add Fructus Citri Sarcodactylis afterwards, Fructus Citri, Fructus Mori, Fructus Amomi Rotundus, Radix Glycyrrhizae decocts filtration in 20 minutes, obtain filtrate, merge twice filtrate, filter, waste, for subsequent use, step 3: by weight proportion of the present invention, grinds into powder be crushed to 180 mesh sieves by Fructus Setariae Germinatus (parched), Fructus Crataegi (parched), Fructus Hordei Germinatus (parched), Massa Medicata Fermentata preparata, for subsequent use, step 4: by the medicinal liquid in step 2, while hot Colla Corii Asini and Colla cornus cervi are carried out molten, then adding the powder in step 3, and gained mixture is being carried out concentration operation, the thick paste of relative density 1.15 ~ 1.20 under simmer down to 75 DEG C of environment, by air-dry for thick paste pulverizing, add Mel, antiseptic, wetting agent etc., carry out beating, rubbing, one-tenth ball, dry, be distributed into bag, both the honeyed pill for the treatment of gastrointestinal acute radiation disease of the present invention.
CN201510370354.XA 2015-06-30 2015-06-30 Traditional Chinese medicine composition for treating intestinal form of acute radiation sickness and preparation method of traditional Chinese medicine composition Pending CN104888091A (en)

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CN106492095A (en) * 2016-11-29 2017-03-15 陈先亚 A kind of Chinese medicine composition for treating due to weakness of spleen and stomach chronic diarrhea and preparation method thereof

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